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    <name>A0A6A6Q859_9PEZI</name>
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        <recommendedName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_431698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2488570.1"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2488570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8507" checksum="1630F5835B19D352" modified="2020-06-17" version="1" fragment="single">PSITGFDPKKFAAASGQRAGDPWSRAEAWRYTGPFTRFNRFKSAFPGLGIATVAFAGYVAAEHFFFNTEEHGHGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8K1</accession>
    <name>A0A6A6Q8K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_520484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8K1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="161"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="708" mass="79043" checksum="7CA32AC97866E6C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9C9</accession>
    <name>A0A6A6Q9C9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_531956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9C9"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAN4"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="592"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="820"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2489312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="850" mass="94518" checksum="354CF0A43201B390" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAZ1</accession>
    <name>A0A6A6QAZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="106" mass="11765" checksum="26FF09675FEC9585" modified="2020-06-17" version="1">MPVYISSTSYANHFNCCKCAGPKSPAWRPKGGPCVICTHIECGKCEQWTAGATEDIAEEGDNGEQWEDQHDNDMEDEWTADTESWEMGGGAEEADWRNGPPVFFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB18</accession>
    <name>A0A6A6QB18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_162468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB18"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24711" checksum="F08C34F4426931EF" modified="2020-06-17" version="1">MCNRSIMAHSHFLLLPTEIRLDIYDLVLSPQNPPLEWAQRTQPFLTCRQIHAEARPALLRAWHDQIFTFKVAMGFIAGLRIHPPHMPLVQHVILRNPVNDLHLDPIDILAKPWMFGLEALNLRSLTLVCDCGGTGRFVEELPQLNQMLEAKKPVSRCDVWKKLKPYVKRGVVGKPPAARFGWRQWVITGRFAVVEERYGCRSHCCYVTLTRLGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBH2</accession>
    <name>A0A6A6QBH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_622372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBH2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="17824" checksum="3EFCE3A351E5072A" modified="2020-06-17" version="1">MYPPSLNAQPDRQEEQLDDKGTTTEIVMWFHSRFTEADKISPRSPRDITEVSPEYPPETRETAPKCVDRDPPEPMSQTADDAKVDLCQSRSSVMLAAESRAPECINIHSPRNPRKKPPEPEIRMSMIRSKAAASVAKRIDDDLEKPLQLQPRMVATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBS6</accession>
    <name>A0A6A6QBS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_441875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBS6"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="208" mass="23795" checksum="721DB9E71619A506" modified="2020-06-17" version="1" fragment="single">EWLLFCEDHHSRMCKTLLFPQLPSFQVIDCQSRTVVPWVYEDTGRVFLTLSYVWGNAYIESLGVDGALPALLPAVIEDSITVTLRLGYRFLWVDRYCIPQTDEAAKAIQIGNMNLIFEHSELTIIAASGNDPSYGLPGVNGNPRRTYPSVTIKDHTFHPFLSNAAHEITHSMWNTRGWTYQEALLSRRCLMFTDSQVFFQCRGMHCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCB7</accession>
    <name>A0A6A6QCB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_597632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCB7"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="17584" checksum="BF5FAF9DDF344F57" modified="2020-06-17" version="1">MAQADLKSRTRGDYKFQLEYRTRWSDNDMYDHMNNSIYYFLFDSIVNTYLMEHCALNPPTSERIGLVVHSHCDYFSPVGFPAMVDLALRVNKLGKSSVTYEIGVFERGEDAVKAVGVFVHVFVDRDNRKPRADGMGPDLRGGLERIVSTPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCI7</accession>
    <name>A0A6A6QCI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_518320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCI7"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11605">
        <property type="entry name" value="RWD_DRWD_ELF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="235" mass="26164" checksum="3842CEF79499953A" modified="2020-06-17" version="1">MAASEDDRFAMELELLHAMYPDQITFTEKSKELKFAQDTAALLLRLPESYPSSGIPEVVSASDSYKTDLRNRMKAEIAKLELAEGEESLDAIIPSFMGLLDQNKAAHDNMPAEKQHERIPGSKTVVIWLHHLLATSKRKMALNPAIPGVSGITKPGYPGVMIFSGPVSAVNDHVSTLKQENWQAFQVRYEEEGQLWEFEHLRGVKEVETMGELVKSIEVDGAGRKNEFLQAVGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDC4</accession>
    <name>A0A6A6QDC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDC4"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025570608" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22303" checksum="571BA088EE6E7C57" modified="2020-06-17" version="1">MHIPTSLLPLLTLSTLLIPALATCSPTNQTSACLCTPAQPATKFPNKCEISKVFAHLAEGNFTAFLDQVTPDVQWTLMGTHALAGVYHNRTIFAVDALARLANTLDPAHKGSMKLTYIVGGGEEEWSVQELHGQGVCKNGLVYDNKFAWVTRWTEQGKIAECRGYLDSALVQRAITENESGEYTYTDQRLTMKRGPVGAGCAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEE2</accession>
    <name>A0A6A6QEE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_531097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEE2"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="25595" checksum="D320381C2E34F7CF" modified="2020-06-17" version="1">MSLKPITLWGHDSGPNAWKVAMILEELNIPYTVKMIEFPDMKKEPYVSINPNGRVPSIEDPNTGITLWESGAIIEYLVETYDKQHNISFAPSSKGYFEAKQWLYYQVSGQGPYFGQAIWFTLYHPEKLASVVDRYVNEIRRVSGVLDRALQDKEFLVGGKFSYADAAFVTWFAIVPLFADRVNLDRDFPVLNAWLERLKARLGIRKILQDRDAAIEATKKRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEG5</accession>
    <name>A0A6A6QEG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_470571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEG5"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="25173" checksum="FDB7E509F78962C4" modified="2020-06-17" version="1" fragment="single">MAEQHTSQRDFPAYTDLPLDYIRVVRILPGAGESDIHCHISLVSLKKQPDYIALSYAWGSPEKEGSSNANARTTRKRKERGKTRTIYLNGHPLGPIRKNLWRFLNQARELASTLTDLQSDYWIDAICIDQSHQEERKQQVGLMPRIYETARKVLIWLGPTYDNSNVSLRELTRPILYWRAKKNVFSVWTKPAGAAISSLCGRPYWRRLWIFQKIMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEW7</accession>
    <name>A0A6A6QEW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA A64-2'-O-ribosylphosphate transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_552980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEW7"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="2">
        <location>
            <begin position="338"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6314" evidence="4">
        <location>
            <begin position="484"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="72393" checksum="29EDF67E64A6F708" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFG1</accession>
    <name>A0A6A6QFG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_565843</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFG1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="483"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2490911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490964.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="819" mass="92124" checksum="E0A914384E4BDA7B" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <recommendedName>
            <fullName evidence="4">Zinc knuckle domain-containing protein</fullName>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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            <dbReference type="EMBL" id="KAF2491151.1"/>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QG71_9PEZI</name>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6QG92"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="177" mass="20166" checksum="2AF9F3DE2A767B20" modified="2020-06-17" version="1" fragment="single">YARKSMFLRRSSERQLREMIENEIAVIKSMRHPHIVSIYCTYQEKQQYSIVLEPLAQADLETWLDQQDGTTATSKLSPLLEKWILCLATTLAFMHGHGVRHKDIKTKNILVQGTRIVYSDFGSSRAFLEENAASTEGPAYGHTRMYSAPEVIAWERRNTSADVFSLGCVLTEIVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHJ6</accession>
    <name>A0A6A6QHJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_530681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2491113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="53794" checksum="AB9AE0006FE6EE75" modified="2020-06-17" version="1">MTDSAHIELQTHAPIEEESRGQEEEELWNGDPENARNWSISRKIYTSGAVSGIGFVCTLASSIYAPGRQETAAEFRIGEIISILPVSLYNLGMAFGPTIASPLSETFGRRAVYLVVLPVFGLFVLATGFCHTFTAVCVCRFFAGAFASPGVSIATATVADMWAPSERARPLIIYYSSPVLGSAMGPLVGGFVAESKGWRWTQWTTLFFATTLFSPIALTRESYKKIILQRKARAAEETRPSRSWNACLDQIPKFIRTTLVRPVHMLLTEPIVTLLCMYMGFQFGLLYVFVIASPWVYSTQYDFSLTGQSLSFLGLIIGCLLAPMFAMAIDRLAQGSSLSRFLLQPTSNSEKAMPEYRLCSAMFGSVCLPTGLFWFAWTARSSIHWISPIAAQCLVMIGSLNIYLSAGMYMMDTYGPLYGASANGANSLTRYSLAAAFPLFTLQMYQGIGVGWASSVLGFCALAMAPIPWAFFRYGPKLREKSRYQRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHT5</accession>
    <name>A0A6A6QHT5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain-containing protein FUN19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_468179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHT5"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="304"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="42805" checksum="F451420CFD7E7B70" modified="2020-06-17" version="1">MASSSYAPTTPTKNMAISSLLSPEETRPDSFTSPMVTTMTRTPASSFSSQRNHSFATDPMSIHAAFLTGDAYPSPPIGDYDPHSQKENNDRSEEDEVRDPPLFKANDTAALIDSDLPLFPPLAGETVNKATQLAIVAHMNSPSVASLPAKPSTNDYELVATFFSEVIAASRRIGGRAWYAQEREYAKMYGSNANRVAKSNSAVSKPYRNIAPKPAFSSRKQKTQLPRPSRAVTKPKRTPQTRVYDSFVQVASPSPKPAKLATNRDDTDYNALPDFSPPNTLAPNSKTLHADWKGQKLDLSNDPDRHLIHENEVNLASTLRLSCATYLCSKRRIFQSRIDALRIGKEFRKTDAQQACKIDVNKASKLWTAYEKVGWFRKEHFIQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHT8</accession>
    <name>A0A6A6QHT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_551739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHT8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="262" mass="28920" checksum="032F5AFA03564AF4" modified="2020-06-17" version="1">MRDDGPNRSLVYSPETPTEHGPLIVIFHGGGWCTCFPEVVEPYCVHLANTYGATVIAAGYRLASAFTFPTAPNDAWDVVKWAAANAAKLGADPSKGFIVGGMSAGANLASVVSHLARDEKLSPPLTGVWLDEPNVVDPSVVPEKWRQDYKSIEQFKDNTPILDKADVEWYKNPASPLYSPLIWPSGHENLPPHYFLLQGMDPLRDEGLIYERTLREDCGVKTKLDVIPGVPHGFHHMLPTFSKSGPAIQKMFEGIDWLLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI55</accession>
    <name>A0A6A6QI55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_104245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI55"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="218"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2492118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1132" mass="130790" checksum="063E8819099DAF32" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ20</accession>
    <name>A0A6A6QJ20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactose-binding like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_442309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:anaphase-promoting complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
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    </dbReference>
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        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="136" mass="15603" checksum="84E2F5B1043E192F" modified="2020-06-17" version="1" fragment="single">LKEISSLASWTVSSSKPGCSIPQLRSPLTAHFWQSDGPQPHLLNIHFFKRVRIVGLRLYLDFEADESYTPTRILFLAGTGPNDLQEWGELKLEQPRGWVWVGRARLPELRAHLVQVKILENHQNGKDTHLRGLQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJJ4</accession>
    <name>A0A6A6QJJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="166" mass="18222" checksum="39BEC638D6673790" modified="2020-06-17" version="1">MDFLDLCFPAFNIALEITTFLAFWALALAILIGILCICLLITLYPVIVRKIDDDDTEGIGVFVGCLCVVLFCAHLFGTILYAVPPVGQKEVLSLRMAIVKSAVTAGAMIGICFGVVWVAAVLVSVVMGLIGLVRGRPVPFGPRRCTAKKWACRKGRWERYERRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJR3</accession>
    <name>A0A6A6QJR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="27080" checksum="ACB2B172C1F31E47" modified="2020-06-17" version="1">MAAEASASLKGFRKGIRSLYTTEHYSDLAIVCRKDTYEVQKAVICPRSAVFAKALRGPGKESEEVEIDLSVEDPKMLERMICFFYHLDYLPTSPNSFLQRHSGQKKEYISGMCPCVSSLEEHDIDLAWRRGTFCVNHTAHNVLKIHALMYAMGDKYGCSDLKIIARAKFEAFLDCSSGCSEVARVIPIVFGTTPDSDLGLRNLIVEEIVKKDYLAFEAMENAVGKTDGLPLAILKAMNSHSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJS2</accession>
    <name>A0A6A6QJS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_467903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2492304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="78296at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="172"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="379"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="459" mass="51865" checksum="88AA55E0E5AA33E8" modified="2020-06-17" version="1">MSSEPDLHRAISMRPLPFNNGFRQESPRPSEASLHPSSSDAITVIKSGKSTAIDSDKIDEPFARHGHRNENDIELQSIPTYDEDTDPYQLASKIKTPEEMAQIRANSSRKRDGFGPLKTNKTAYRARKIAKFYEAQNENIETLLKPVDDHRRLAKEEEGADHLQFKIAVQGSFIANVILAGLQLYGAASSGSLSLFTTMVDSVFDPMSNITLILCNRAVKRVDGRRFPSGKARIETAGNIFFCFLMCAVSAIIIVESIRELVTYNSSQDTKNLHIPSIIAVAIAFCTKFCLFLYCWALRNKYSQIRILWEDHRNDLFINGFGILTSVGGAKLRWWIDPMGAILLSVLIIFLWLRTAYSEFQLLIGVTADTHMLQLITYISMTHSPEVKQIDTVRAYHSGPRLIVEVDIVMDPNDTLRHTHDVAEELQIKLESLPNVERAYVHVDFETSHAPEHFLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJZ5</accession>
    <name>A0A6A6QJZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_529629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJZ5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="16771" checksum="75C1068147E8DE14" modified="2020-06-17" version="1">MAGCRVASLRPEEAQKPFDGPSPRALSHACQRHGACHAHRTVSKAAPFLPRGRAANIPRPRERRRIGGEKPFVLPIHKGRSSPSESSVNRLFNGLGCYGMSGKKAVDIIFELAPQCVDVLFEWRPPCLFGAGGLANVQVPEDIRASLEALSHAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK83</accession>
    <name>A0A6A6QK83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_574191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK83"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="36759" checksum="64D7CB9BD35BE958" modified="2020-06-17" version="1">MEEDDDEFYGPDSSNAIGGDQSETKHDASNRPSADKDDTLDAELESGEEEEEEEESDSDIEIITDRPQQEESKPTIKPAAESTKEVSRAPAEPSSSRLAQQQGSAPKASLATPTAPSAPQQLGTSFPEVRASTIDVNADPIYPPVGKTVSQIDIDADLAESTKPWRLPGADQSDYFNYGFDEFTWEMYRQKQASMASTLTAQKAETEQFQRMFGAAPMPTNASAAPPVPGAPTGPAAQNNPMAAMGGMGGMGGMMGMNEEQMMQAMQAAMMQQGVTDPSQLDFNAFMASMGQGMPGQQQQPQQQQPNQGYGQPNQSGYGNYGQGQGGGGNYGGGGGRGGGGRRGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL45</accession>
    <name>A0A6A6QL45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_528513</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
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        <subcellularLocation>
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    </dbReference>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2493188.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118190" checksum="64224FAF60605F12" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL57</accession>
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        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00249"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492433.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="631" mass="69251" checksum="AA7DDFF80C694D2B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLK6</accession>
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        <submittedName>
            <fullName evidence="4">Ser/Thr protein phosphatase family</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_551667</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleotide catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
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        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="374"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
            <begin position="496"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2493009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="646" mass="71731" checksum="6324766B840E27F2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLT9</accession>
    <name>A0A6A6QLT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_583799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="613" mass="70509" checksum="EE4870F7B2F8ED13" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMP1</accession>
    <name>A0A6A6QMP1_9PEZI</name>
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            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
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        <name evidence="20" type="ORF">BU16DRAFT_541056</name>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="reaction ID" value="UER00614"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="55714" checksum="92B4FE6A5CB0C2C6" modified="2020-06-17" version="1">MALPVLSSARGFQSVVAGHTLLLGQIAWYRRSELFSNRRQFASQPAEKPAQDEQLGKSASFTSSSPPSSPSSGTTSPVASSSGASSVQSLPADWEDQLPNLDDFSQLPHKDFGKNQLIETNEEFKRSLRQITRQFPAITYSFAYGSGVFPQTDGSSSSTSLSPHPNPPEAISKWQRGGGKMIDFIFATKFTEHFHSLNLMRHRDHYSFLGSFGSSVVSHVQDSYGAGAYFNPYITVNGTLIKYGVVNFSTLLRDLTDWDTLYLAGRLHKPVKILTEEPNIRVANQRNLMAAVRCALLLLPPQFTERELYTTIASLSYQGDPRMALGSEHPNKIANIVTHQIRNFRLLYSDLINSLPNVDYAESSSFKDASWIDDLKLDRPMTQNMETAFRGNMVRRLPKSFRQKLYFLYQRKFGIPGREFQEMLEASADEDAKGSLKKPLGSDFDRRVASEADLPKMVAKAVNQTVKWPSAVQSLKSGFTAGPGRALRYVREKRAKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMU0</accession>
    <name>A0A6A6QMU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_563473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="18540" checksum="B71757E9D9384122" modified="2020-06-17" version="1">MEVCISSMVLWFCGGGAGVRSRTAASFLSRPSTFTHGRQNNHTSTETWRQVEVCLAGLPASSAALSVITDARIAQSVVHPESNHRSRLFSHPPSPRHIGSTGRSKAASRPSPTALIHLQARLRRTPQFPRAFPEASAATPIVSPYHASLVADRTSRRQLLPAVPEFAARSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPC9</accession>
    <name>A0A6A6QPC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_61473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPC9"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="29856" checksum="B173648218CD9C92" modified="2020-06-17" version="1">MHRKQPITLLVYNQLFPNPRPEDPANFSAHLSKNLVGEVRIETATFYGSLDTIEARYPGLNYSHPPHRKRLGRFAHHARLFRAFDDLGLTEHEIQGFCRWEGTLWARERYERDEGVKVHDTTGMEIGEWVDKRARQGGSKGINVKTRIEVEIEEVRQPQQNGVTNASSGMDVDEAADADMADREDEESDEDEVADSVGFALNERLRHAAALREQGVSAVMDPEWEQFLKEQERGEGGEMEIQPSSTSAAPTVSRPPVPSMGTATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPJ2</accession>
    <name>A0A6A6QPJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division cycle protein-like protein Cdc20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_63498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPJ2"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="280"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="601" mass="64451" checksum="D355238D6B5B7053" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPN7</accession>
    <name>A0A6A6QPN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(S)-2-hydroxy-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_510829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPN7"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF140">
        <property type="entry name" value="FMN HYDROXY ACID DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025631945" evidence="6">
        <location>
            <begin position="17"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="332"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="387" mass="41897" checksum="9294952765ADDC37" modified="2020-06-17" version="1">MHSFITLATLIVAASAARPFLNEPDTGLEEYLGTDFPVGKLPNLTDIRGIPDFDFAARNYLNASSYSFYRTGAAGEWSYRNNLEAFSRVRWRPQALNDVHSVASTLPTKILGHNFSAPFFIAPATRAGLAHEAAESNLVKGAYAGDILYITAIYATLSIEQIAAAKPANGSQVLFQQLYAAANLTAVQNNLDRAKAAGSKAIVFTIDAPATSTRHRAARYDLGNANSDTATLTWALYAQLRNMTSLPIILKGITTVDDVRKAISVGAPAIYVSNHGGRQLDGSPSPLEVCLEVYENDPTMFQKIEIYADSGVRYGTDVLKLLALGVRAVGLGRPFMYANAYGVEGVTHLIELLKTEIAADAANAGIQDVHRIQRERVNWKPLTTNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPQ2</accession>
    <name>A0A6A6QPQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclease PA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_528332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2494192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
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    </dbReference>
    <dbReference type="Pfam" id="PF02265">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
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            <begin position="1"/>
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            <begin position="19"/>
            <end position="318"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="34809" checksum="7DF7ABE4E3248319" modified="2020-06-17" version="1">MRVQSLLSSSVLLATAAAWNTDVHNQVGFMAEKFLSPYTTSILAKILEPEYQGSIGRAAAWADAYAHTAEGRFSYQWHWIDSSDNPPQLCNTYYNRDCTKGGCVVSAIANQTEILKGCIAAAKSGELSGGKNLTCSYALKWVAHFLGDVSQPLHASGIAAGGNFFNVTFGGKATELHAVWDGEIIYADSKVPRFSNTSLDPWMNGLVSRIRKDDFFEPTASWLDCADPSTPVQCALSWARDTNQWNCDYVYSQVFNGTDLLTSGYAEGAYPIVELQISKGALRLATWLNKLVYGDYKKDRQVILRTNPSWVGGPSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQI4</accession>
    <name>A0A6A6QQI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_512194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQI4"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="270" mass="28653" checksum="89E3C28FF3F49D2C" modified="2020-06-17" version="1">MEQTRALNALEPFLALSKSANSPRAAADLVSQATSAPNTYVFAELLQTPNMQALKQSPEYASHLTLLEIFAWGTLADYKANASLPQLNAAQHQKLLLLSLLPLARSHTTLTYAHLTTALSLPSPRALEELITTAIYASLLTATLDPAHGLVNVTSIAPLRDLAPGAIPSLAATLAAWSARCGGALDELDAQIAGVRKAAVRREKERRKRERGMETAMGLLEEKSAGAAKRGEEGGQGQGEAMEIDQEDIVGRFARGVKKGGLAGLGGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQK7</accession>
    <name>A0A6A6QQK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_527754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494768.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29272" checksum="F8640F4A6CD3EC1A" modified="2020-06-17" version="1">MFGRVKAVPILVPLFFAIAISAESNFWLFPGRAGDSNDYSLDPIFPLSSTQRLQWNTDFDTYNLTLWQQSSPGGAATSGAIIYAKSSSDSEVGGFEWNVQTYSLKLEDSPVFFIWVLDPEGNSFTSHYFNITAKGVSSSITASATSTATSTSASTSDASARSVTATQSVPVQTLSAPTQSPQPQNNNSAFKVGLGVGLGLGIPLVLLLGVYLGMKAMKTRRTLGQPTDLPIYVGSDPPKYPLEEFSQAPSGELLHTEPVELPGHGYYSPRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQM8</accession>
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        </recommendedName>
    </protein>
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        <name evidence="20" type="ORF">BU16DRAFT_62791</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
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    <comment type="subcellular location">
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    </dbReference>
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        <property type="entry name" value="Ethylene receptor 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
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    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00448">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0418">Kinase</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="18">
        <location>
            <begin position="550"/>
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        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="19">
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            <begin position="975"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="1164"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <end position="758"/>
        </location>
    </feature>
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        <location>
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            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1129"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2494033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127215" checksum="20E77E01089E21CF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR17</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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                <person name="Andreopoulos B."/>
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                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="433" mass="46750" checksum="7A0EE8C1146124F8" modified="2020-06-17" version="1">MRGQGGEDNRVVDAALKRKRVQGPETAGTRGEGTKRMRVRDVGVSVEGHDEHMITAKEKADTRRNWDAEEDSRFDPPPSGQELSDSKNERAVLDRRRDRSNSKTTAFGRTTSSSTHTATTLPPNDGPNISTRSRPIPTPTSSKSTSVFTSAPTNTNISTTFTTPMDTTQPVTRAALPTRKIFDAWNSSSTGHQRAENRLGGSTDWRHSRQKKLSAQFTSGMHGGRRIADTVGAGSFTFGKDGRKANGGWEAGASGLRGAGQSDVKSWLTQERKRDTKSVVLLDKQTDDGNRGTREEDPNTNTIPDPQLPQIFTSLTFYINGSTAPLVSDHKLKRLLASHGAALAQGLARRSVTHVVLGTENARGGVGGGLAGTKIQKEVARTGGKAVRFVGVEWVLESIKAGRRLPESRFEGLKLAPEGQGSVLEAFRVREGG</sequence>
</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
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        <source>
            <dbReference type="EMBL" id="KAF2494943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47410" checksum="927C4D88D8877465" modified="2020-06-17" version="1">MDKDPTYGLEVFRKISLRIATWTSSTKRKATTQGNEVESQFLQLPNELLLLIGEALTPISTLRVRQTCGKLRYILPPDLGLYPLNEFDWEISLLEKRSLPPAGDLPEPQLHRFIAYRNDAPRFRLWCNACRTRHSAYYFSLGQRATPPHKRCCLGMENCFRMCAHRSVTYAEVNTLLQSGEEISCQHDDHHIPQDSSSTPGCHLRKATCRYRPESPNVEYNRWLPLVRIPIAMASSESVSKVKAALNDMSEEDQLCPHLHINDESVLFALTTMLTKARYRMYSHDEERFSARNLPVYSPGSWASKYRVVLCKAVDCSCYVEISRFRLAEEEYDTIVMKIEQRWFHSTPTNAGWISAVAPMWLGSERYPGHHVLGQMNCEDILNGEYDTSDQIENQRDLIRLAELNDVKGERS</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="PANTHER" id="PTHR38790:SF9">
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        </source>
    </evidence>
    <sequence length="1040" mass="119668" checksum="66A722D7011B863D" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="10613392at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
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        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="51010" checksum="B1DB83AA438F9019" modified="2020-06-17" version="1">MAAVLRSVEDGGEHGGSFAAEVLKELPWLGGDHLPWHGGSAAWVRVRLMVRRPSSWPCRWCRGWGGAGSVHRGRRGMGRVFSPQTALLHPQPCLRAPSRPSGTPLAPLTKQTLSWSRRRGEAEAARWRTSWPGLIDASRRGLTSIRPAEPQACTVETACDDDDDDDITDGKTTAARRQQTAPMRSSSPTIPPPSVASSRERRTARRAPISTAPDAGCCSNGAMTLSIYIAVGSLQCHNCPQSARPGKGRRLQVRAGPAGTGIMPPKMLRCYRSGRRRSLAKRPNAPAGRDEGGQRRRALASPAPHDGQSAATICGRDGGGAGGNSALLRNVSLCFRTELRRSADQEQAGTAVSSFGDAEERSAAGRLTACREVYRETVGSAHPEWRAPSPSESSNIGCGGWTCYRRRTWRLWLETQRKPRSTGSLAEKVGAAANAARGPPVVHVGSVVCCRLLQELQAAVIPASLNGVGGQIQGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVQ0</accession>
    <name>A0A6A6QVQ0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Vegetative cell wall protein gp1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_370908</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
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        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47338" checksum="1B4941EC756963AB" modified="2020-06-17" version="1">MNFHPTYPTPPPGYMPYDYIRTPPVSPSPGTHGYYSPRYAANTATPSPRGSPKTHARRSSQQEPPAYAYTSTRGAPQYFPGYSAPRYFASQPTPQRNPDYVSNFDYTRTKSRHYRDMDGLPSMHRSSRESKQRRPSHSRYAHTTHVFDDGRGYVYDSNVYDTPPPPYEPYARYQSYGRSTDHYYHDQVPIYTEAEPTSRSRPRRASHSSRPQPPTPKRPSTAKATPRATEEDARRAGIPAGYSYKNWDPTEEPIMLLGSVFDANSLGKWIYDWTVFHHGPSTPLSEIAGELWLLLIQLAGKVKRAEECMTKIRKTENREMVEDFLESGERLWIRFAKLLKVCEEYMWKAAKKETGEKKPVTMGKNSGCEFVDSIFGRDRELEKTEKLMTGMRLWSMRFDANCDDILRYPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW26</accession>
    <name>A0A6A6QW26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_561208</name>
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    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW26"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025574500" evidence="2">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="30820" checksum="8167EA50A058F3B1" modified="2020-06-17" version="1">MKHFLSTLCGSLALLISAVNGAPFLDSRQDDGPYCGELSSEQQGASIDGVAGGDTHLMLTKDKCHPMILCAPKLVNNVRHVKVYPECACYLWDNPTCGNAAKGVGVNLDVDLPKDLDQQVGSYWCKPAPNNTLPVTILSDASTTDLICKLDHPDKKASTETSQTLPPAKRAESHDLVPRTDTCGFFSTEHGGQGNFGFLNKDELCHTFPPGFDNGVSSIHVSDGCECSFWLEHHCISWPDVHASNAFKDLNGKFDKELSTYSCRLKDSNAKTGFFYGAENVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW86</accession>
    <name>A0A6A6QW86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BU16DRAFT_376936</name>
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    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0098754">
        <property type="term" value="P:detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13417">
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    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="584" mass="66022" checksum="51B193BC2894BC96" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWI0</accession>
    <name>A0A6A6QWI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_525707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWI0"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="85" mass="9266" checksum="D12ED85686356AF6" modified="2020-06-17" version="1">MAFFFGLGGLFYVSVLLVNAIAVLSEDRFLARIGWTSGSDPGFGGMQENSVKAKMVNLVSSVRTLMRIPLIVINTLIILYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWK3</accession>
    <name>A0A6A6QWK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_458004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWK3"/>
    <dbReference type="OrthoDB" id="3546893at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="36433" checksum="D8C53CA78E14F0F7" modified="2020-06-17" version="1" fragment="single">MAPLDIRDPFGGHRELGTGALIGILTGVGLAILGLLVGLTWLLVRAVKTHKRLLADLEQRGVNIARPRMAESSHTLITRPRAVLRRNSFLPFNSQSGWGALPSHETIPNPVPPPPLPPQSVTTLRSTNHDKRVSRLSWPFPGRRKSGRALQLKRIRVAPLSAIVESPKASPLVPILNGPIQGRSSAYHKDDSNSQATDPQAITLAKRYGPNRSKSVAAIPVNDSSNPPTSFDRPRLHQRSMSLGSQASGLAPDAPMPPLPLEVARIRSEAKRKSLLARSPSRFSVSSFESAGSSILATQSSPIVKQNNLHLQKVTKRHSVCLGPRPPRDTLTLHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWT2</accession>
    <name>A0A6A6QWT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWT2"/>
    <dbReference type="OrthoDB" id="10500691at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="17598" checksum="8911DFA8704F87AD" modified="2020-06-17" version="1">MAYLIHYTVLALHLAGPRPLIQPSPFIASYTAANRLILPTCIGGTLLSRLLEFEGHVSPHRLSSSRLLHLPPLRPTVVRQGSTHQPRIQRHHTTFAEWRATEKAYKKEGEKEADKPCTPTRFETPAPDGRRCRERSSGSPSPPATIQPPIRPTSDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWV3</accession>
    <name>A0A6A6QWV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_344100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWV3"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="174"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="492" mass="52640" checksum="695C0168CE795B16" modified="2020-06-17" version="1">MKIIIVGGGIAGTSLYLHLLQHLPNPPAPYPPHELLIYESHEPKPSSSPSTSTSLSSPSSNSPESEPPTTPNLTPSTTTIGGGLALAPNGMRILARLSSELHEAVLAQGFANERFIFRSARGWRLSSMPCTDARVPGEACVSMSRMGLWEVLRGFVEASGDGEGVIRYKKVAEVGQGASGKPIVKFEDGEVEEADLVVGADGVRSVVKKGAFGEGYAPVYMNQAGVGGFVKGPLPDEVKREKGMVFTFGGNGFFGYGSSASEEEESLMWWSTYHTPSLPTSDDLSIPTITTELRERHAAWKDPVIQTIISSVADSVSSIYPTWTTPPLPHWGRNALILIGDAAHALQPTSGQGASQCLEDGLTLSLILSHYLNKVYNETDASEQSGSGVDLQATIDATASVLYAVREPRVREISDAAKKMDRGKGDIGVVGEMVMCGFMWLFGKVPWIAQLLFGDMNERLYAWDVDAEVKKGIAKYETEARTESGTATAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXA9</accession>
    <name>A0A6A6QXA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_483980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXA9"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.340.10:FF:000004">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000013">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="433"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="674" mass="71300" checksum="EFB548F84A053950" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXQ3</accession>
    <name>A0A6A6QXQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_459261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXQ3"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="75"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="505" mass="56897" checksum="91B454468657DB50" modified="2020-06-17" version="1">MPGPASKNSNQIVQEWEPTEPWAVDYGDFKSMSAEAKEAVIQKEADEYGIEKPKGYKVSFHYNAEVEYHHFGSSHPMKPWRLTLAKQLILAYGLEYAMDLYQPRPATFDELAIFHDRQYLGFLQSITPQNLDSDPAKAKYLELFGFGGESNDCPVFDGLWNYVSLYSGASMHAAHNLLNQQSDIAINWSGGLHHAKKNAASGFCYVNDIVLAIQHLLTQHQRVLYIDVDVHHGDGVEQAFESTDRVFTLSYHKYGLDKWGAGFFPGTGNINEVGPTDPSNRGKGHTLNIPLEDGIDDEQYKWLFKTVTGAVILKYQPTAIVLQCGADSLGGDRLGRFNLNIKAHGFCVEHVKSFNIPLLLIGGGGYTPRNVARTWCHETAVCTGSELHNNLPMHLPYLQAFDGAENGGGMLYPNLHNTKRHDNQNSREKLQKLVAHAMENLRYLEGAPSVVVNNHGLTEAQIMRIREKVDREMREEAEDKESRESEQGRRRRERNTGGRGEHRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYF3</accession>
    <name>A0A6A6QYF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_525825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNA_pol_III_Rbc25"/>
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        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rbc25"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="208" mass="23413" checksum="CAF39C095A9CE462" modified="2020-06-17" version="1">MFILTTISDLIQIQPEEFGKTSAQAIKDSINTKYANKVIQQVGVCICLFDLTKSSEGNIGHGTGIVNVNAEFRLLVFRPFQGEIIIGHIKISDPTGIYVSLDFFDDIYIPEALMPEGVRYNAVEKVWVWDTDDSELFYDNNETVRFRVENEHWDTNEERPPYRIIGSMTISGLGPVLWWEETREDIEAARQACLAGAANGDAEMEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYL0</accession>
    <name>A0A6A6QYL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_367872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYL0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="161" mass="17811" checksum="73CBB105A63CFC63" modified="2020-06-17" version="1">MPARSPSKLFWRQTLRGNAPHLDAAPANALQALPHCTKLMPLRAYVRPLRPASNACLLKEILICPRNAPGNALKLPSAWSAYSFGVCKAACFALRPDTQTLRPSRLRASPEPDPQFGRRVPFERDPQQTPPAQVEGLRQSQTPWHACTAMVSLLIRSRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYS6</accession>
    <name>A0A6A6QYS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dsDNA-dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_538366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="RTC4"/>
    </dbReference>
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        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="432"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="591" mass="65633" checksum="6AD277C27D2178B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1U6</accession>
    <name>A0A6A6R1U6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">Purine-cytosine permease FCY2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_505159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498675.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46262" checksum="3649EFC1E97834B5" modified="2020-06-17" version="1">MAVATLSTGMVGGSMGLAFWDCFAIIVVVNLLSCLLPAWTASFGLSGLRMTTFSRYSFGYWGNLLVVVFSMVSTTGWNAINSISGASCLYALSDGKVPTWAGVIIICTTVWLICALGITWIHRLDAFLWIPPTIVWCVAAGTGAKNFHGAAIKSPTGANGAASALSFMAVVFSFAVSWVNCAADYNVRMPVNTPRSKIFFATYAGILIPTVLVQTLGAALYSGTELNKSWKLAYLDAGVGGPLQKALEPAGGFGKFLMVLAALSAIPNNIPNNYSFAMHAQNFGPWAVRIPRIILVTFGFIAAIIVGCFAAKYFHDTLQTFLSIIGYWTIIHIVVVAEEHIIFRANRWSRYDFDAWDKPALLPFGWGAIAAFCFGFLGAAMGMKVAWYKAPIAGLIGKKGANIGHELTAAFSGLAFPLFRWLEKRYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1U9</accession>
    <name>A0A6A6R1U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_548150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1U9"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="349"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2498362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="433" mass="48471" checksum="153FC2B85C4F10FA" modified="2020-06-17" version="1">MAADPAHMNGADPQRLRWKYLDKILSRPGPFTDPDWEPGEAVIEGLSRAKIFGAGGLGCEILKNLALSGFKDIHVIDMDTIDVSNLNRQFLFRHADVGKYKADVAARFVEKRVKGVKITPYCGKIQDKDDDYYMQFAMVVCGLDSIEARRWINATLVGLFNEEDPDSLKPLIDGGTEGFKGQARVVFPTMTSCIECQLDMHAPRAAVPLCTLATIPRQPQHCIEWAHIIAWEEERKDITLDTDDPEHITWLFQKALKRAQEFNISGVTYSMTQGVVKNIIPAIASTNAIVAASCCNEAFKLATNSNPFLGIPETDNYMMYTGDESVYTYTFQHMKKPDCPVCGNLAKNLEVDSKSTLQEFIDSLAERPEAQLKKPTIRTEAKSLYYQSPPALEEQTRPNLSKTLSELVSDGEEVAIQDPAFQIAFKFKLVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2I6</accession>
    <name>A0A6A6R2I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_536694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2I6"/>
    <dbReference type="OrthoDB" id="2439692at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF2">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025450489" description="DUF7707 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="4">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="206" mass="21156" checksum="926E18148F60BAF5" modified="2020-06-17" version="1">MRSTLALGVLALVSSTYSQEQYTIDPDSVSLSLRQFWCNQQTSECPLICLQYPENSASTQSNTCDPASLTFSCVCQQGETPNVTEYSQTVPFYICQEWGNQCVAGCGQDNACSNDCRANHPCGAQSPVKANSSTLSATSKPTGTGAAATNAQTTATGAVYTGFGGAAATSTGSAKKGAAASAMQVGSSYGLAIVFSGLFAGFALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Q6</accession>
    <name>A0A6A6R2Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_558872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2Q6"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="232" mass="25045" checksum="01F2A962C0AF2816" modified="2020-06-17" version="1">MAKQNLLVLGATGGTGLAFIKEALIHASKPNLTLLVRTPSRLPQEYLDDSHITVVKGELNDRIVVDNALQGVTAVISFLGPYMTLKATLLRDTSTPIADSLPTLFAAMRSANITRILALSTPTGLPQPVLETKPWSWWAAGWFIYLVVPQGNAEMTKIGSLVSGQHDLEWTVFRVPSLTNGSAEKVVEAGYLGAKEFAVTAELTRGSLARWVLAEVEGREWVGRAPAVANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R329</accession>
    <name>A0A6A6R329_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_536702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R329"/>
    <dbReference type="OrthoDB" id="10325099at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="287" mass="32440" checksum="A475F00106354CD6" modified="2020-06-17" version="1">MAVSYAKRQRIMDDLFDADKSPANSPAHSVIAKRDTAIARLPLRNDFDSQRAERPSIARSLHTPDTDPWLKAPSPKRRKTSFRRRASVWVLGPKMDKGKGKAKMEDGVETVIPDPLGNGDPLAVYEQDALITDNLPNRVRAKSLPTLAQTVPKPLADAPRRYTIAITNFVYDALKKLGIRKETQEQTSQERTPSCAFEEHGMAGALRFDPMYFDSIRPDGPSTFWKNKEYQNQPYELCPKYRSELKRRSGDSMRTYQSSRNSQISRIKSIRSTLSNLTNHTGNSKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R341</accession>
    <name>A0A6A6R341_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_524344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R341"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="433" mass="48453" checksum="4700F47F93CE71E7" modified="2020-06-17" version="1">MDPSATFANCQVHQNTSDTFQHECHTNTSQYAVQDLEKQIRERNSRGWRKIVINFTPSWFSVNMGTGIASILLQNLPYNGRWLYWISVIIFCLNVLLFVTFLAISVLRYVMFKGLFMFMIRHPVQSLFVGTFPMGLATIINMIVFVCVPAWGPWAVTFAWTLWWIDAAISVATCFSLPFIIMSNHKSDLSTITAAWLLPIVSTIVASASGGIVAEVLPNPQHALWTVIVSYILWGTGFPLAMVVLVMYFQRLTIYHLPPREVIVSVFLPLGPLGQGSFALMQLGKVALKIFPITGTFEPDSGRFFYNLGNYAALIIWGYGLVWLFFALASISRSRFPFNMGWWGFTFPLGVYTVATTTLAKDLPSQFFKVLGTIFSVTVILLWLTVFIKTLQRAATGKLFFAPCVKDYEAQLAQKTVGPSAAEGDSETRSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4L5</accession>
    <name>A0A6A6R4L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_480216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4L5"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="35655" checksum="7AAA625995D4805B" modified="2020-06-17" version="1">MSATLLDPPPHISPPTALHLSQQAPLVLASSPASSLPWPISLLTSSETPETWSIHENLLLACLRTGDDRSARQVLDRMVARFGDENERVMALRGLYEEAVARDKGSLEKVLKEYETTIKDDPTNMPIRKRHIALLRSLGRPTDAIAALTYLVDSSPTDAEAWAELADLYASQNLLPQAIYSLEEVLLITPNAWNIHARIGELLYLSAISNGEGGASYKGLAEAMRRFCRSVELNDGYLRGFYGLKLTTSRLLTLQVPKRNDSSAEDLPLPPVTTIEKLNELATTKLAEIVRRGSAKESGWGGYEEAELIAARELLNRDGANVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4V2</accession>
    <name>A0A6A6R4V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_615137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4V2"/>
    <dbReference type="OrthoDB" id="3946060at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="118916" checksum="98B018A6B5B2F263" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R592</accession>
    <name>A0A6A6R592_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_558962</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R592"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="35"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="414" mass="45463" checksum="F46FA1177251E91D" modified="2020-06-17" version="1">MAALGSYFLDLVYSFTNCMVCFPGSPQLKINTRSFKILRLLGEGGFSYVYLVQDTSNQQLWALKKIRCPFGQESVSLALKEVEAYSLFSPHPNIIHSIDYSVASDKSDPGAKTVYIVLPYYRRGNLQDMINANLVNHTKFPEKRLMVLFLGVCRALKAMHQYKVQGGPGGAASQNKAKRVRQEAARADADAAEEVEMSASRRRGANGNQDQEEMEQEPLMEDEVTISQEGIAPGGERAYAHRDIKPGNIMIADDGKTPILMDLGSLAPSPTPITSRSLALAVQDTAGEHSTMPYRAPELFDVKTGSTIDTKVDIWSLGCTLYACLVGKSPFEARSEETGGSLSMCVLGGDWRFPDEVPHRGKQPAPIEEAISDNVKEVVRKCLQVEASERPDVDELIRIVEDVIVTLPGDGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5K4</accession>
    <name>A0A6A6R5K4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_524290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5K4"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="37575" checksum="D05794D11A61952A" modified="2020-06-17" version="1">MSGFHNIKGRISRQFGGKLHPDDEAYLSYHDVRVTRGDLESIKNDWLTDNAIAFWEEYLEHEKLTAYPKAQITLLRPSMAFMLMQTPNPLTLKDALPDFTLTTHIFLPINDNRNVEVAEGGSHWTLLVVSVLDGVAFHYDSLCPSNDAEARTVTQKMATLLGGKPLRFVNMGDTPQQDNSSDCGVYVCLIMKHLLLHRLLTADANGKVNMSMANRELDPAAGRKTMLRIIEERRKEGERRRSWVDSFFYYLLGLLSAALLAVMGANDLIGEARARFGGKVRVRVRVRRGLGRRMRSCSRLSRPPSCGGWWRQRFWMRAYGVWGGSRRAGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5P6</accession>
    <name>A0A6A6R5P6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_501697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5P6"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="170"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="383" mass="43945" checksum="77EC6EB905E4D555" modified="2020-06-17" version="1">MAMDTDAIPNLLGDMRDEAPDDLQTHFISFEDYWERKLWHELTEALLEYFQTPASARHRIQLYDNFIKTFAAKINQLKLVQLGLSTASCYRDNQERLTFLTALAEKVNKPASQDAYVYATVAAADIQLKLKEYDGARKKLDECEKILDTFDSVETVVHASFYRANADYYKHKMDFAAYYKNCLLFLACVSVNDLTPTERQSRAYDLAIAALVSDSIYNFGELLLHPILDTLSHTQHAWLRDLLFAFNRGDLVAYDVLAGNIGKNEFLQQHQTFLYQKISLSALTETVFRRPPHDRAMSFATISEETKVQPNEIEHLIMKALSLGLLRGTIDQVSEIARINWVQPKVLDMKQIENMRGRLREWDSSVNQLGNWIEGVGKDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5U3</accession>
    <name>A0A6A6R5U3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_548005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5U3"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="467" mass="50682" checksum="042250ED314984F9" modified="2020-06-17" version="1">MPPSICLRRLSLAPSDLTAHAMASRSLLAYTQTTSFSHSASLSAKPGQGKPAGPARGERTLNLGKNKKVQRDMGKRPAPGERKALRKRVVLSNTNALVVEGLNDLTVSNIETGDMQGQVVGLSEPVIDQLRAVEAFKATQGWYLFRRPAMLMRKETAQLSALMGDVEAQKKTVRRILVGDRASGKSTLLLQGLAMAFMRKWVVINFPDAKDIVSAHTEYAPLPGSNPLQYTQNAYTANLLAQIAKANSAVLSTIVPSTDLRLPIPTTRKTTLADLAVLGSKNPELSWPIFNALWTELTQPGRPPIILAVDGLAHIMTPSAYLSAEAKPIHAHDLVVVRHFIDHLSGKSVLPNGGMVLAATSGSNQPASPALKFSVQLAEARAQGATDLPMWNPYELVDQRVMEVLTDVDTLKLHGLDKQDSRTIMEYYAASGMLRKQVDEPLVSHWWTLAGNGNIGELEKGSVKMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5W5</accession>
    <name>A0A6A6R5W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BU16DRAFT_282061</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16 22" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="287"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="1154"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="21">
        <location>
            <begin position="1280"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="680"/>
            <end position="791"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="918"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1114"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="405"/>
            <end position="417"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="559"/>
            <end position="570"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="726"/>
            <end position="735"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <begin position="736"/>
            <end position="752"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
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            <begin position="782"/>
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        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2499744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1296" mass="144318" checksum="F2BBA7AA5F0E4723" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R730</accession>
    <name>A0A6A6R730_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_452918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="192"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2500182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="487" mass="53151" checksum="C2D1B1095009E7A7" modified="2020-06-17" version="1">MASGMPLPLPPRTPTPPPEDEQSPIGLGIDQQFSPAKLGYNPDALSPMSATFPPDRFGTLGGPNTSTSQRPTPNSLYSPASSTFPYSPMSAVSGNSEDKTPSMSGSDNARNPFNFQPMSYVAGKNAAANKQELGRRRGHKYKHSSVSHQIFLEPPPRAPLQLPASLPIPTFKEYRSSMSREQKSRFIWCFCHLFVAGFVQWSAHESLALTVLSRLLCYDALGAFLCVAVDVGGNFEVWKRSSIRHPFGFERSEVVAGLGMSVGLLFMGLDLISHSLTHALEDKGGHEAHHAHEHERVSPGSIDLAALCAIISTLVSAILLKNHARVGKVMRLGAVSSLPSLLTNPSHFLTLSCSALLFVLPLLSIQMYVWLDRALSFTVAISMVALGWRLGWTLGKMLMMSYSGPGVSDVLYDIETDPAVTAVEEAKFWQVHYGLCQANLKLRARRLEDMGRLRDRIGSLVRTRLGGGYGSGGQKWEVSTQITLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8P5</accession>
    <name>A0A6A6R8P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_452461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8P5"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2500774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="470" mass="52042" checksum="1DC6F9412CB8704F" modified="2020-06-17" version="1">MTYALPKSHQDLMEKSLVETDSEVAEIMKKEIQRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNENIDAIELLCQARALKTFGLDSEKWGVNVQTLSGSPANLQVYQAIMRPHERLMGLDLPHGGHLSHGYQTPARKISAVSTYFESFPYRCDIKTGLIDYDRLEENALMYRPKVLVAGTSAYCREIDYKRMREIADKVGCYLMMDMAHISGLVAAGVNTSPFPYCDIVTTTTHKSLRGPRGAMIFFRKGVRKTDAKTGKETLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAQTNEFKLYQEQVIKNAKQLEVSLKELGYKLVTDGTDNHMVLLDLKPQSLDGARVEAVLEQVNIACNKNTTPGDKSALTPMGIRIGAPAMTSRGLGEEDFKKISQYIDTCIKMCIDIQSKLPKEANKLKDFKAKVASGGVDEINSLKKEIAAWAVTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8V9</accession>
    <name>A0A6A6R8V9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_555487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8V9"/>
    <dbReference type="OrthoDB" id="10687191at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="374" mass="40242" checksum="27E2C63D9783FBD4" modified="2020-06-17" version="1">MAVMVGDESDVEEGTVVSVPEEVVLLLVSERLFVPVDNGVEAIEENSLEDEALAELLFTPAEGDTKDGENDVLKVELLGGPLLNVPDGDGENDDESSLEEGLPDGLLFGLLGGDTEGGEDTALEDDALLFDKRVGGIEIGEESMLEDEDALEVEIATERVVGIVVGIEDENPDAPPEVVADTEAGLMLLVMEELFDPEDDDVGDGEEAALGEIATEKVVGTVVEIDDGDPDALFEVVADTDAGLELLLMERLFVHTVEDARGDEENAAEDVMLDEVTTLGCVGVEEEIASLDRLLDTPEVDDSDEVEFEYILCERLSVVEVMLGDERPALDPVLVNEEIVTLVELLDTPDVKELPVISAVLKDRLPLEEEFPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8W4</accession>
    <name>A0A6A6R8W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_190056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2501069.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9S0</accession>
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            <fullName evidence="7">Transcription factor TFIIIC complex subunit Tfc6</fullName>
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        <name evidence="5" type="ORF">BU16DRAFT_523250</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAF2500483.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="83830" checksum="636D3890F8D766FD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAL2</accession>
    <name>A0A6A6RAL2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_535108</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500527.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBH8</accession>
    <name>A0A6A6RBH8_9PEZI</name>
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        <submittedName>
            <fullName evidence="12">L-cystine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_522130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
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        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2501093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="32038" checksum="D376E36244681632" modified="2020-06-17" version="1">MTDAELIYLAKAVSRVLGWVYFLCWSLSFYPQPLLNWKRKSTQGLAIDFPTSNVLGFFAYTVSTAAFLYSPTIRSQYAQRHPAAPEPTVRFNDFLFALHGCLLCIVTYSQFWPRIWGFKVGARQKASRPILGIFWGSILGVLITILVVAIKGKDNGNDSSGWAWIEVIYAISYVKLVVTVVKYMPQVYVNYKRKSTVGWSIGQILLDFSGGIFSMAQLMIDSSLQADWSGLTGNPVKLGLSNVSIFFDIIFITQHYILYRAPKTAIEDDEEWQEQQGLLAQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBK6</accession>
    <name>A0A6A6RBK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_522730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBK6"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="255" mass="26866" checksum="1453BC20247313F5" modified="2020-06-17" version="1">MTVKNLQGLSAIVTGGSRGIGAGIAQELASRGANVLITYQSASSQAEEVASKIRALGSEALIVQAAGTDKEAPARIVRAAVEKWSHIDIIINNAGAGDDCLLKDLTYDLWDKILNTNLRMATFLVKESMPHLGKAPRIVNISSVIGRMGGSWATAYCASKAALEGVTKVWAAELGHSHNATVNCVNPGPVGTDMWLRDTDAAVLAEWDTKMKETPAAPRIGTVDDIAQIVAFLASEESRWSTGSTVNANGGMCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC34</accession>
    <name>A0A6A6RC34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_448617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC34"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="77" mass="8991" checksum="50AFAD9AF797AE29" modified="2020-06-17" version="1" fragment="single">QEECSTIREHYMRTGEGFLLVYWRTGRRSFEEIMTFQQQILRRTCPMLLLIRMTISTSISTSTTRSPENPALSTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDC6</accession>
    <name>A0A6A6RDC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_555920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDC6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="192" mass="20888" checksum="D6D0F2202EF8888C" modified="2020-06-17" version="1">MRTDLRPSPIQKTLSRFVAVTICKALLISAPTSVFEHTYYRFSCSMWNPGAAAVVRRLTEDWSRGLRDVSQLSAQPGQYFGGLATKRFSGGTSPWDQICTATNGTSIIGPRLITGTAAAERSEVAILKKGRVRYQRRTPYCMASVVNITDKAISAIAKAIITADTPTVVAKRGRQLDKCQDPALLFTSSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDY9</accession>
    <name>A0A6A6RDY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_474989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDY9"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="11"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="36238" checksum="ED62200A88927780" modified="2020-06-17" version="1" fragment="single">MVSNQAAWLHKANTSLVVGEAPMPTAGPDELVVKNAAVAINPLDCHMQKAGVFVQQWPAIFGCDVAGEVHEVGSEVQGRFKKGDRVIGHAINLVSGRPQDGAYALYTVVPANKAAILPDAISFTDGVVVPFALEAAVCTLSLKQPGIAMPGVATPALGLPYPSLEPTLSSNKTLVVYGGSSSVGSMTTQLATAAGIKVISITSARNFEMCKSCGAAEVFDYHDPSFAQNVVEAVTKSGQEFVGIFDAISTPTTYADDLAILAKLGGGHLACVHPPPDSIPENVTAGMIFAVDDIATPVWRDYVTPALQVGKLKCLPPTFVVGKGLEIIQEALKKCEAGVSATKLVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REA1</accession>
    <name>A0A6A6REA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1793-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_475057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REA1"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025693340" evidence="2">
        <location>
            <begin position="22"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="358"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="536"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="714"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="833" mass="92857" checksum="ECA993DE4D0540BE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RED3</accession>
    <name>A0A6A6RED3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_521468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RED3"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="91"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2502804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="466" mass="52963" checksum="8F2F20D37D769C35" modified="2020-06-17" version="1">MATQAPPAPARASPSPAAAAVPNGKPASPYVERSNPMPNGQGSAPQTVTSKDPKAAAQAASDMRNIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGMGKSTLVNTLFNTSLYPPKERKPPSLDISKTVSIQSISADIEENGVRLRLTVVDTPGFGDFINNDESWDPIVKNIEQRFDAYLDAENKVNRMNIVDNRIHACVYFIQPTGHSLKPLDVEVMRKLHTKVNLIPVIAKADTLTDEEISNFKQRILADIHHHKIQIFEGPRYELDDEETIAENNEIMSKVPFAVVGANADVTTADGRKVRGRRYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKENTNNFLYENYRSEKLTAMGVQQDSSVFKEINPAVKQEEERSLHEAKLQKMELEMKMVFQQKVAEKESKLKQSEEELYARHREMKEQLDRQRQELEEKKARVESGRPLEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RET0</accession>
    <name>A0A6A6RET0_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_576790</name>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="KAF2502882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="36611" checksum="843AB7955C522ACF" modified="2020-06-17" version="1">MTVYLSTGVDGSMLLEGPTMTVRCWNIHNKHTDIPNVPKRMWTYFSRNPEGLEADDWSEEFVDIMPNQGSLHSIRYILSWILDMCTNGEHDLTLLTCEDNLQLYVTAVHCNFGRAATYLLGYLHNHLFRDSVLNNNDIYNLRFLPDNDPLLKCAAPRISSLPYFSFEECRFSLLSDPRMLCLVYEANMEQMKHQTAEERQQEEFLERYRWQESLKARKEKIDDTIRTWKGKLPWRELDWYREQLRISRNPRKDEYEDGPWLLGQNDVWFKGQWSATWTKHGDVEPVMVDGIRRAKHEGERIRTTRPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7F9</accession>
    <name>A0A6A6Q7F9_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="KAF2488388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="143" mass="16506" checksum="7D171930B701DA8D" modified="2020-06-17" version="1">MWYPQKFCPRRIPRPLSRPLLSKYRRPMLLSAAEPCKFTDYRYVTVLLEMLEHHPYLCGSHMTTLFLATAPRAIARGLAWEVNEASDKDEQMMGPTKDVIWLDGSFSRQAEGLNLWLRKAFAQLTASRRASEKAFGLPLNFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8E2</accession>
    <name>A0A6A6Q8E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_520496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="KAF2488718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="64"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="954"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="1025"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="287"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="632"/>
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        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2488718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1472" mass="161134" checksum="5669CCF390E74590" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA09</accession>
    <name>A0A6A6QA09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_544668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA09"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="538" mass="58923" checksum="C5858BE53634F104" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAY8</accession>
    <name>A0A6A6QAY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_519642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAY8"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025704464" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="167"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2489565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="384" mass="42780" checksum="A97483080BC79815" modified="2020-06-17" version="1">MKSPLILSLYATAITTALAAPRIEQAVLQQPEQEQFLIELAPGQRHYVTEHEKWELRKQGINFFDITDNEDLGLINHKVGIQAVTFPSKTSHNKTIAPMLKKLEKKNMRKHLEKFTSFHTRYFKSDYGKQSSAWLLGQVNDTLSEAGALEKGAFVKPFEHPWGQSSIIATIPGKSDKTVVIGAHQDSINLWLPAFLAAPGADDDGSGTVTILEALRVLLTSKDIIAGKGENTLEFHWYSAEEGGLLGSQAIFQSYEKEGRKVKAMLQQDMTGYVHKTIEAGEPESVGVITDFVDPGLTEFIKEVITDYCEIPYILTKCGYACSDHASASKAGYPSAFVIESDFKYSDDKIHTTEDKIEYLSFDHMLQHARLTLALAYELVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBN8</accession>
    <name>A0A6A6QBN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_215437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5151921at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCJ1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="300" mass="32775" checksum="0D6ED2499E3B592F" modified="2020-06-17" version="1">MPRPSFLTTLTSQYRARMSASPTPPFVPKQALGILANAVDVYEKTGGKVTAQFAEECVKLVSPIPADSVIHDNACGPGTVTRKIMATSPPPTIQIVATDSNPAFLSHVRAAVIANKWPVEVENMRSEAIEKPDDYFTHSFTNIAIFMMGSAGLDGATEIYRTVRPGGVAIVNCWQSLAWMQPIIAVQMATRSHGRVGKPPVSWADGTQLRKIMVQAGFMEENVTMSSSEASAVVKDLRSWAELSWAYLGGLQGWAQEDEDRWDEAIDMLVEKLKEAVGTTMDKDGVVYMKASQHMLIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCJ3</accession>
    <name>A0A6A6QCJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_597584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCJ3"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="312" mass="34936" checksum="335E2A89F1E9DC89" modified="2020-06-17" version="1">MSGPSNPYAVLDLPHDVDEKVIRSAYHRLALLHHPDRVRSPNERSDSEGKFREIQHAYDVLKDSTKRAKLNRNLGQWRQGVSSQRSASASTSSAPVDVVGFDLEEFLKSLKTNSAPCQEEGKTASSTVDPQTTEERQANDIRDAAALAFAEATEMKKEGNEAVEEAANETGKARYTGGPKSHRYLNSRKGTPEHRTHTAATAAAYDKTASFGTIAYKHYGAAAQAREDAADGFQKAADAWAKLFRTFDLSRDLIFEDRALQNVLLCRENVKVARGLVDMDREMEERWEKQVDQWSRWSLAWFEEAKESGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCK0</accession>
    <name>A0A6A6QCK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCK0"/>
    <dbReference type="OrthoDB" id="3905718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="61249" checksum="0AE49F6B284703B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDG0</accession>
    <name>A0A6A6QDG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyl phosphorylinositol ceramide synthase SUR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_566479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDG0"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38844" checksum="4A06C76685E59D43" modified="2020-06-17" version="1">MRKSVLIFLVTNILIVALLVHSLWVLITLLFVNGSEDQISRAELPAPNSNVISSRPQLIPKIIHQTYINESIPAHWQGPQQSCLDLHPDYEYKLWTDKKSREFISTEYPWFLETFDGYEFPIQRADAIRYFVLAHFGGIYIDLDDGCNRSLDPLLAYSAWVRRTTPTGISNDVMGAVPRHPFFLKAIDSLPDYNRNWVMPYITVMASTGPLFLSIIWRHYNSATPSPLENDRVRVLFPDEYNNHPWSFFTHHRGSSWHGSDVRLIFWMGHHWALLTFMGCLVSFTVIFFVWWFCNRTVLKGGRKTSFLPEGIRSVIYRSVSGKKDYELVDRHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDH5</accession>
    <name>A0A6A6QDH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_183205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDH5"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="438" mass="50143" checksum="1858B2C296FFC815" modified="2020-06-17" version="1">MPQPIQWRENHASDSSANNSARSETTSNPRSTAPTEYSYRETYTQSDTSNGRVKDRADTWATDYSRLPPYLPRASVDTYASTSDEDLAEEDDYPEYEVPQYNHEVFPIDAIPTTPKDFADLFPTSKRISIRHDDATIDGNMNLRVDTQLEGRRGKKQSYTLFHLRMHDLRNREFSLRRYCRESGREVCHSIRKYQKPPTEKRPVLARASSAFATLRNKPDTRPSTAAGLKRSDSGYESMKGIEDDSRPKSAGHANGRALLPTNTLKLEFSNYAHIEVKRRGAKSNKRYNFEYWGHHYGWKRVCKKDGDMEDVSYHLLREDCDQPLAHISPVKLTPDQAHEEAARGGWVPPCYMRITDDRILDAMTDISDVVVATGLMALVDDCIKRRFHTKQSTQLHIPLIRSGSFKMGMEYVGPKRLIDEVFHRRAPPSRQASALHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDH6</accession>
    <name>A0A6A6QDH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_471018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDH6"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2490104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="25542" checksum="8F69FF8EFAF81D09" modified="2020-06-17" version="1">MSTPGIKSRPAATPIDILPTDAARLYTHIHPALVLSLYALRFNAIVADPVPALLQTLIPLSTLQTAYVTICLPPTAGSGSSTPAVVPKTAKKRAGGAAKATSDSNTAKIVPALLSLILSLLAITPLTGITLILFGAPITTHFAHTFLAAAHIAILAFLPLVYVLGVDGERWREVVGLLLPVDEVVGGMVGTLVGAWAGAVPIPLDWDREWQKWPVTIVTGAYAGYALGKLAGGLVFKGRKIMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDJ4</accession>
    <name>A0A6A6QDJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDJ4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="272" mass="30723" checksum="03BD61D2E28241F4" modified="2020-06-17" version="1">MSLPQHPLCFEPNSTYGNISSGDVPDNQNDTPTTSSADYSWDDSDHRQIRSPQPSRPIKTLSKVSEATGALQPLDVITGKSDGTKRTRQRSHSSTSAHKRPRMQEDELWSLYTEIRPGPGPALTSQHITMQEWSALHDRTAAGIHSVERNMRLMIVHRQKLSTSTAHYIYKAVGSLRLELELGFLQLAVRDWAWDYLETAFEDICSYFLYSAAASLEGRNVDRNSLLVDAIEELTAGMELALQESTWEETEELYEEQTEQEAGEETEDDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDN7</accession>
    <name>A0A6A6QDN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear cap-binding complex, subunit NCBP1/CBP80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_517872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDN7"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="310"/>
            <end position="500"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="815" mass="92051" checksum="EF7282F9AE7917DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDP1</accession>
    <name>A0A6A6QDP1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Alpha and gamma adaptin binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_170959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Irc6"/>
    </dbReference>
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        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30874" checksum="B06E43D6E98E9A44" modified="2020-06-17" version="1">MEIDHPRRILAVGAPDSGVLHLLKDLTGSAPDLITDSTAGLSHEWKLETRYYTATLPIWIDEIPHVGEWREEFVKPEAREVVSVLGAWVYCFRKPVKEEHLDAVKETLKAIADVVEKACGYSSDSVLLAVAMPQSTTPHLERSFEEWEELCSDFGFEFVDFEAKGKNEFGEPVGVQRLKEALETNDWAGYGEDLDDDEGFESTFAAEEAEMNMELFGMKSAVNGDEDGVDKADQVDDLEHMMQRMQAIKEKSEGMPEAERKKFAAKAVSDMMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE47</accession>
    <name>A0A6A6QE47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_131657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE47"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="350" mass="40352" checksum="91F2F732DDAB5738" modified="2020-06-17" version="1">MYILTWFSSQSSSNSVERTVNTLNIMENFAPDPPVDPTIGQNPLPDLNLDILYNYLRLEGYEERDNVDPWVLRGQMLRAFNSFHRSFYWVAFESDEPDSPARVHNIRASVLRQHPAAEAVFPSIADLEPFIQSVRDRARVVRRIIGLPDPDDEITLGVEQIWEPSSLEIGRMIQAQGIRYLFRLIGELGDDQAQLPANSPEMRIAHGLSNAFNDSAEEATLRFHHYRATALRIADRRERVRRRQEQIWDSIVENCDVDPDEICPICKDDYIEEAPVRTKLCGHIFGANCLGTWVEEHKNCPMCRRIFNIEDSTDQSDDSDDSEDSDDDVYRDLYDGWDEHVETIIHSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEV7</accession>
    <name>A0A6A6QEV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_158268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEV7"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="19"/>
        </location>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490554.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="389" mass="40924" checksum="1690FD37A2D72D3D" modified="2020-06-17" version="1">MKGFTYAAIVASAISGALAAPVEERGSPVEKRAVTLTGNPFASRTLYANSYYASEVSAAAAAITDTALKAKASKVASVGSFLWLDNIANIAKLEPELKLIKDGEIGGFVIYDLPGRDCAAKASNGELAAGDIATYKSSYIDPIVAIIKKYPNVALALIIEPDSLPNLVTNDDLATCQASADGYKAGVAYALQQLNLPNVAMYVDAGHGGWLGWDANLKPGAQMLADVYKTAGSPKQVRGFSTNIAGWNAWDLTPGEFSTTSDAQYNKCQNEKIYVDTFSPLLVAAGMPGQAIIDTGRNGVTGLRLEWGDWCNVNGAGFGVRPTSSTGDSLADAFIWGKPGGESDGTSDSSATRYDSFCGKDDAFKPSPEAGAWNQAYFEMLLKNAVPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEW4</accession>
    <name>A0A6A6QEW4_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2490935.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="19044" checksum="4630C1DC7A88178D" modified="2020-06-17" version="1">MAPVDHHKLPLARSHVDNQRDSGVLGAKATPLPLVPLDGSCRADWVLQGCVRIEGAGGCTGSRRAVKHQPLSDVLFPHSLRSHQQGHLRLSIWMCINSILGRTRRLHPLRSTQWSDFDVSRLQSLHSNFIIENEHRISRCSGTASKGQHRHHQYAFRSICRTLNILVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QEW8_9PEZI</name>
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            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
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            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="325"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="355" mass="40438" checksum="9CFBB99A039275C3" modified="2020-06-17" version="1">MSSEDLKDHAKTAEVDFYELLGVAYETSESDIKRAYRKTSLQYHPDKNPGKLDVIEKFHLLAIARDVLLDPEAKALYDRLRQQKRQRELEHHLLDGKRRQMKEDLEARENGFKRKRDDDFDAEEKLAREIRRLAEDGKRRRMQREEMLSREKQEGEEPEDSSILESDTAPPPKGPSEVPDENRTVKVCWLREGAGVAIDKTKLAEIFSKFGETDSVWVRKDKKVRRSDAAKHKSVMATGFIVFRSIVAAHAAVEDAKEKIPFLDSVSWWKKPDIPGIQSPPAPKLSAPSTPVSTQKSFRASFPGVRPGGASLGTPSFSFSPQSPSLEEVTMMRLKKAEKRRLEDQIRKQEAAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEZ5</accession>
    <name>A0A6A6QEZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_530545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEZ5"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2490965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="80" mass="8692" checksum="E4537D027AD284A0" modified="2020-06-17" version="1">MSAEHNYKFDVKMTCGGCSGAVTRVLSKLDGVKSFDVSLEKQTAEVVAEESLDYTTVLEKIKKTGKEVRSGEADGKTMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF01</accession>
    <name>A0A6A6QF01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_159554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF01"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="15688" checksum="2170E0844E84B588" modified="2020-06-17" version="1">MAPRRKAATEAAKASAALKAGRFRSTYGVPTPRQPSPSPPLAPKTPTPIKKARKARAAETRRQKNARMVKTWATRRANAAEAARQKQEEEESDAAERESQIDERDNRAAFREYYRSRNALILRIRADMRTARRLERNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFA0</accession>
    <name>A0A6A6QFA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_543339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFA0"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="17103" checksum="3C199080030BAEC6" modified="2020-06-17" version="1">MATSMASAQNTGTPATTTVQTPVLRLRLPVGTLHLRAEPAEERHIQWAEDVIDNEGMGKKSSKVCCQYHKPRPYDESSDESSDSSDSDSDSEPDNSNARPVGGRRGGGRPQGRKPHDHHDHDHDHDGEGSGGNPPKHSQAPSRKRAPNAYDKAPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFD8</accession>
    <name>A0A6A6QFD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L35Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_566361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFD8"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="104" mass="11689" checksum="08EC62BC1D4CAF89" modified="2020-06-17" version="1">MPEAGHRLKHLSYTRGKRNTSPGTSLLKLEGVDDTNAARFYCGKRVAYVYRAQREKQGTKIRVIWGKVQRPHGNSGVVRAKFRSNLPPKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFM4</accession>
    <name>A0A6A6QFM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_543447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFM4"/>
    <dbReference type="OrthoDB" id="5139943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62527" checksum="FD7E7578C142AE75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGK3</accession>
    <name>A0A6A6QGK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10350746at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="337" mass="39159" checksum="0FD717FC4F20621F" modified="2020-06-17" version="1">MVASRSSSKRAVGNPSEQKSKRKGRDLDKTYRSRVSKNTNASDNANTSAPRRNPARAVRQPKATFSVFEKFKILPPELREMVYYHALDLDNKKYIRPLAEASTTTPGDFGILQADHQMHDEASAVFERHATVDIDMGIDDDRSDWLQDILPKVHNPQYEPVNPTAGYERIEAQREPNEKKLANYRRAHFHVGRGDHHLGLFRMHKSPYMDEVYDYIEFWVANAEEDRTRLATLDLGRLLHRAAEYDMNTRDSCTRRGNKRLERQRKAAIERVWEMLDLMASDGNCDWTVTCYPWSPDEIYRLMGDTVFDDLQSKCEDLGFTFRPNTAEERLAYDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGV5</accession>
    <name>A0A6A6QGV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_468768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGV5"/>
    <dbReference type="OrthoDB" id="4732550at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="842" mass="95437" checksum="DC5FA867A14A7705" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH46</accession>
    <name>A0A6A6QH46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_621632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH46"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="402" mass="45082" checksum="B1D8000D93D7D91F" modified="2020-06-17" version="1">MAFPTPYCYEPISSSTLRLLEIDASSEDVVCSLSCFPMDHPPEYYALSYVWGKEKPTASIICNGARLALSPHLLTGLRALKLVKQTHYWIDAICLNQQDEEEKAIHVPQMSQIYSSASRVIIRLGPASDGAVTDGKHDSQTIEAPYKLIPAALRLLKQWLTVPEPPCFSLGPEDAHLALDGIGQLNDHFENTKDWALLEADTLKSHGFPELHDSVWPAVLHLFLRDWFSRLWVLQEAVLAKEIDVLYGHTIIHWAAIVKFVVDVKLMVTGMTHDGHVYPRHQAIADYHSFVSDIFGATVRSGQEPMIDSSSTRYFAAIQSAWQCSCFFSTRNGCFGIGPDFLRKSDSICVFFTANTPHILRRRTEVKSFEFVGQAYVDGLMDGTVFNEEIEKVGSHQSFSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH52</accession>
    <name>A0A6A6QH52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_621257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH52"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="202"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2491745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="853" mass="96339" checksum="14ADF385F85463B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI54</accession>
    <name>A0A6A6QI54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_584640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI54"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="270" mass="29329" checksum="A9DF974B6266B4A3" modified="2020-06-17" version="1">MTEYVTTAYRGNIAIITLNDPKKLNALNADGYHQLAQAMTTVANREDIAITVLTGSGRYFSAGADVSIGGSQPSNEDTTRFWLRSFVSQNIYITHAFYTHPKILVTALNGPAVGLSAALIAFSDFIYAAPHAFLLTPFSSLGLVTEGNASRGFVQRLGISKANEALIMSKRISCEELVQVGFVNKVFDVGSKDSSDKFLGEVLKEVDDRLGAHLNADSMVKIKALIRKPERDILDRQGVEEVFGGLDRFTKGIPQKEFAALASGAKKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIS6</accession>
    <name>A0A6A6QIS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_530053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIS6"/>
    <dbReference type="OrthoDB" id="3914591at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="40182" checksum="8B4B9011902706E8" modified="2020-06-17" version="1">MPKSLLGYLVQQVFPSYSNVPLAQRFELAKNIRAGGWQNVPDLIRSVLGSTLGKEAVSHVDSDGRTLLHHIALRWGFGDFGRNRPGHRGVFDDCCDAVVWRQPYRPENYQHPWRTLLRDTLSAGAPVHAVDKHGRTPLCSLIRQTMVRYVERWSHFRRFDRLLDVWLIELSMAGVDLLTYGETEDTLDFEGALNHGMSSDFPKLLYFTQGPHPQDWQFFFTEPNDIYAGDFWTSIEEPSQSRQFATDFNSAPRILGAWDDPLSHSLEACPHRASPYDLGADLHLNQDCAAEYGKENEYACDPDFNIGTVTANECYLRHRSLESCKGCKAFLLDSQSCLSSSAFISMYGFSLHCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIS9</accession>
    <name>A0A6A6QIS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_529904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIS9"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2491357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="458" mass="48701" checksum="D2306555DC8F1998" modified="2020-06-17" version="1">MLSRSALRRGALRCQFAQPVQKRYLAEAASGSFQYQTGDASGVKIASRDLAGPTTTLALVSKAGTRYQLLPGLTEGLEKFAFRGTERRSALRIVRESELLGAELESYHSRENLVIGAKFLRDDLPYFVELLAEVASSTKYLPHVYTEEVLPLIKLAHKKFLASPKAIALSSAHSLAFHRGLGTPVSPASATPYTKYLAADTIEYFAQFAYAKPNFAIVANGAEHADLSKWVNEFFGGVSAKAPEDLLQSVRDKQTKYYGGEERIAHGSGNSLVLAFPGSSSFTGGFYKPEIQVLASLLGGKSSIKWSSGFSLLSKAAASPGTSVETKSAIYSDAGLLYININGTAENVSATAIEAVKTLHSIAGGKISAEDIKKAKAAAKFQELETGQDITAGLELTGSGLTHGSKAYQLDETAKAIEGVTDAQVKAAAKTLLESKATVSAVGDLFLLPYAEDLGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJK4</accession>
    <name>A0A6A6QJK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_584282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJK4"/>
    <dbReference type="OrthoDB" id="3786778at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025693010" evidence="2">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="214" mass="23563" checksum="E6897568CF22C323" modified="2020-06-17" version="1">MRFSAFSLFALSSLFVSSLAAPTSIQTRDVAVAEVEQRDASAVAVQERTLPEIVVIVDGLVKEVFSYTAAINVTISSCESISIDFTKKIEIIAGIQVQIQKIIAAFSLATLKIYQLKLVELIEIDFKLLVSLAIKVWIEIIYTLLYAAAVLKITIIELLGWTFTLFLHGYISFLLAIGAVVAKFIASIKIDFQIYLFIISKVFVNFGALLAACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJQ4</accession>
    <name>A0A6A6QJQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_551505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJQ4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="12"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2492678.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="42390" checksum="37D5956AC40BE9ED" modified="2020-06-17" version="1">MLKTRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKKVLQHKDSDDPTAAHVEEGVKIKPITVELDEEGTRISLTIVDTPGFGDQIDNEASFSEIVGYLERQYDDILAEESRIKRNPRFRDNRVHVLLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEEVVEISGRKVRARQYPWGVVEVDNPRHSDFLAVRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGGAAADSSMNPEDLASQSVRLKEEQLRREEEKLREIEVKVQREINEKRQELLARESQLKEIEARMHREQSGQLAEHDAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QK84_9PEZI</name>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35023" checksum="8A34A9B9647109F7" modified="2020-06-17" version="1">MGPFQSSKPERNCSTAPIPPPKSNPSPPQAQPQCLFLNLPAELRNQIYTDVFSTKSPIKNALALLETCRLIHLEAAVLAYATTTWVTTKSDYYSLAKSTSTLPRPCFTAIAHIAYSCPGDYSSIYDLSVFLSNAVFHFPGLHTATLLVRHMFPVMRVERQISSVPGHPLGTDDWFAKTIRLFKSGRALAWPKDRPWSVQWPAGRLDSGQFETWAVSQEEEEMWMHCIVSRDGEGGQRTETRVEVMNEFRTLGRPEFVPWEPPAEKLPVIVIGESERPRAIQWNGSPEWWIEKWKRQREKRWLWQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QKH5_9PEZI</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_466950</name>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
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    </dbReference>
    <dbReference type="Pfam" id="PF02705">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="756" mass="84220" checksum="BCE17FE1FFA3A5E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QLX2_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="152" mass="15950" checksum="A34D492D71384A2D" modified="2020-06-17" version="1">MGTRGTPLSPVILKKTKCSRRLGDHATSPPSHSPPHGQKDTVRIAEPSPSSWVRAGARFGVPTTGLALNGAGWSKGSAERDTPCISWMQGATGCPSSPARSLPASANQLTANSALNPNSLPKAASVRPGDCTNCMHSRPLLRHRPARLRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QM24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM24"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="24744" checksum="6E0171E56443641B" modified="2020-06-17" version="1">MPRKTGAQASSSSNGADSSDPTTTVLASTNSRGPSTFSDGGPLPKMIVFDLDYTLWPFWVDTHVTPPLKAIVGKGAGTKVKDRYGEGYGFYGDVPEVLAAIRAKGIKIGAASRTHAPELAREMLKLLYVPSTFSAATPASDPSSTQQMKALESFDYLQIFPGNKITHFEALRKQSGVKYEEMLFFDDEARNKNVETLGVVMCLVRDGVSTKEVDRGVESWRKRNKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM71</accession>
    <name>A0A6A6QM71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-type alcohol dehydrogenase-like protein C16A3.02c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_466561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM71"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="345" mass="37366" checksum="9FA949726E14C1B2" modified="2020-06-17" version="1">MATKGIPSSFRSWQYRSTAGGLENNLTLNNVPMLEPQANQHLVRILAAGLNPADYRLSEFQFLHKVAFPKPASPGNDFAGYIVKPAPGSTLKPGQLVFGGAGTSFMYGGAMSEYGIALVSNTVPIPTGLSIIDAAGITIAGLAAYQSILPYSKPGSRVLLNGGSGGVGSFGIQIAKAEGRHVTVTCSTANVTHCKSLGADEVIDYKTQNVIQALKDSPYKYDLVVDYVGNDHNLFWEADVYTSPDAKFVTVAASHHLSFVRFIVAAEYMPRFLSGAKRQHLTVFAKPDREDLSQIAEWMVEGKVKPVIDSKYKFEDLREAYQRLRTGRARGKLILEVAPEGEYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN16</accession>
    <name>A0A6A6QN16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_583293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN16"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="27764" checksum="BA9B26A30C0B4A4A" modified="2020-06-17" version="1">MMGFGRVAGRDLPLADEVFESFPVSASYLGDGLPKSTPAAGPLVTTTGLDKLVKRMFEEQLGSVPSLQDVGKNGSAERFLQLLKRWREGARARGIELEAVIKAEFQRNKDEGSPMAFNPWDAFDPYGREFTSRAGSAEPWNKPVIPRSLVLKNEQGAWLSGNTLLLLRIHKAVADVERELGWITVPEKKRPPIGSISSATGGGEKAQNQIQMQMGENFMEEISERFPELMNVARFIAVGAEDDDSSKLNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN91</accession>
    <name>A0A6A6QN91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_562669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN91"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55956" checksum="BA027E3011B10674" modified="2020-06-17" version="1">MSILTHALEPPPEPPEATTSTESRLLSLPTELVRFICGCLDLNSVGSLRQTCKELCIQSNSVFQANYPQAIQLVMTYQNLACLVNLSMDSKLSNRIKYVSFACRAIDRGYVQQLLDPDCNPVKRGVIDQDFQLFYLLLIHQNEMRANGKDVDMLGAAFRNFKNLEAVQISSLPLEKPEDISPNASKTTSLQKHWEHRKLYAPSTIAELGGGYGGGDYHSRYLPREMFTGGILSGILTSKSLYPAHEVIARALKISNISSINVDVSMVLPNLIYHVHDPWDARNSRSWNPTNVAWGNIVQSHLRSLSIRHEDTYESATRVLGLLESAGMHNHIEELQYSNSKSRFLGGWLQRESYDCLHRFPALVRLGISDSFVRAVQLLQFFSRCSATLESISMRDIHLNSLLTWREVFASMAQLPRLSSVFLESLTEDYGPAYHSMRGAHSRVLELHGVGISQSLQKMTQTHIASPFRREYRIFRDSLRTGHEPLWRILFMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPD2</accession>
    <name>A0A6A6QPD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_63959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPD2"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="621"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="746" mass="83465" checksum="D0795E0DD8A9EEE7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPW3</accession>
    <name>A0A6A6QPW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_463192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPW3"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="512" mass="57719" checksum="5F9F89528AF31727" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQK0</accession>
    <name>A0A6A6QQK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_563304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQK0"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
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        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025372324" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="384"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2493127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="987" mass="109955" checksum="24B6764C72ABA815" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR31</accession>
    <name>A0A6A6QR31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_464933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR31"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="241" mass="25747" checksum="66F53AAB73560281" modified="2020-06-17" version="1">MANAFNSAIAKRSLRTIQTELEFLVDSDVITKDQFTTIVNQLPLENTRAQNSATPVNSMAALAIQQPPQQQQTQQQPQHQDEKKQKIGYYADNNPAPPAYPAAPLAPAVLTTATALYQYNAQDAGDLALMPNDSIAVTEYMNAEWWKGKNERTGHEGIFPSSYVKAVESKGAAYNAVQPYQQPQPSSYGNMPVDVSQGAGGQPAPSGKGAEMGKKFGKKLGNAAVFGAGATIGSNIVNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS99</accession>
    <name>A0A6A6QS99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_385383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="337"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="849" mass="95670" checksum="67E2216ABACFFD1F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSD8</accession>
    <name>A0A6A6QSD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_386157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSD8"/>
    <dbReference type="OrthoDB" id="4738706at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58254" checksum="FCBCBC9288E935F4" modified="2020-06-17" version="1">MPIWNLFSKGKKKKLEAEVLFQVALQREQAAAQHEQAIEVERQYRLEEAALAKQRLQREEEDYRRQQEFAEQNRRYTRAFPAPLRSMENRARARQELRRQQEEHQHRLTAEQEKELLKQMAREHKIIRGEQAEIKARQGQNSPKQFQYESFTHDNRDTKNIVAEAKSKGGYYNIPANLEVLDPVRSEPQLQMRVRAAEKSDFNSLGSNATRAVATAHFSSRSVPEDVKEPNAEEIYPEENSGTENLENSNTSDGEDSSYSGTSSSPTRNNALLVSQVEEKRQALLDRLMEYFYSTFDPSARGFKSYTGPNSLGNSGASGIGNGANKHSSEATGSHRAVDNDSLSHKGDAGDDSNDGPPRGGKLRKNWSGSVKRLACPYFKHNPRRYQDITSCPGPGWSSVPRLKEHLYRRHASPIHCPRCYQHFEHTMELKDHQRASEGCDVRTKTAIEGFDKEQETRLRSKKRSAVSRSEEDKWREVYIILFPDEDESNIPTPCKHPQSCSLGQHIITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT68</accession>
    <name>A0A6A6QT68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_386567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT68"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2495322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="530" mass="59565" checksum="4594EBE0A13EBFB5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU81</accession>
    <name>A0A6A6QU81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_618457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU81"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="107" mass="11191" checksum="45F8F9E7654B1BCB" modified="2020-06-17" version="1" fragment="single">SPGYGWITGFRCPASCHSRGARCSSPISLRLPSPDGGPDAVTSLGSGAWLASSLTAVSLTALIPGQPSPERLSPACSTRPTLHIVHAPFQHASNRTLPPRRLPLAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV62</accession>
    <name>A0A6A6QV62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH dehydrogenase iron-sulfur protein 3 mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_589963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV62"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="9">
        <location>
            <begin position="104"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="33089" checksum="54201EE0CAFFC46A" modified="2020-06-17" version="1">MALRLSASRPLAVAARCAASSSAFAPRAFTTTILRAKEVTGASDAPNMRFAPRDAPGKLKAPIVNPADKYAEKGEALHKYGQYVMSCLPKYVQQFSVWKDELTIYIPPSGVIPVFTFLKYHTAAEYTQVTDITAVDYPTKDQRFEVVYNMLSIRHNSRIRVKTYADEATPVPSICDLYDGANWYEREVYDLFGVFFVGHPDLRRIMTDYGFDGHPLRKDFPMTGYTEIRYDEEKKRIVVEPLEMTQAYRNFRGGSAAWEPVGPGEDRKPDQVRASFLGLDLNTTPSTAKVANLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVJ1</accession>
    <name>A0A6A6QVJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVJ1"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025591912" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33970" checksum="451EC489DDDFBAF8" modified="2020-06-17" version="1">MRSPSYLLSLFSLRAITLTLAHNSSNPLLDTGANLTFALPTHPVYTFPVGTWIENLAVRANGKILATDDSLPRVYQIDPLSPHTPAILLHEFTDTASILGIVETIPDVFYVCTANYSSAKLEGYGQAYIYKLDMRPFSPSIPSSAAVSKVATLSEAKALDGLAWLEPRDRKGEGLLLVSDFLAGVVWSVDIATGAVAMPINSTYTRSTGFGVNGLKIRDQELYFTNTQQQILVKVAVNSKGEVVGNYTVLAQGGFGPDDFALDAEGDAYVTSFEVGRNGVVFVPREGGEAVYIAGMAGPTAAAFGRGEGEGLRRHDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVN4</accession>
    <name>A0A6A6QVN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_549945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVN4"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF43">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="52805" checksum="0FE5C0366BD66407" modified="2020-06-17" version="1">MAESKDKEVSIQTEPVSAWWRKAVGLIWDSVEGDPRDRRYVQRLDTYLFSYICLGYFIKYLDQTNYTNAFVSGMKEDLKLYGNERNWLNTYFNIGIIIGTIPSQMIQLKYVRPSIWIPSCEIVWTALVMAMAGAKDVKTLYVLRFFVGLAEACSFPGYAALLGGWYGPTQLTKRVAIFEQTSAIASMFSGYLQAALYKGLNGRLGLAGWRWLFIFDGVISFPIAIWGIFAIPDLPHTTKAFYWSEDDKKYGVERIEKLGRKGPEKLTLRVIKGVYTNWRLWAFILPYLMVAQAGSGTNYFNLWLKAEKYSVVHINTLPTAGSAISVVAAFAFGIVADRTGHRWPAIVTIQVLVMISNILLSVWDISKGAKFFAFYLSYVGAAAQPIVIGWGHELSAGDPNLRQLLVATGNIFTYCFSSWLPLALFPTYDAPKYQYGYQILILFGGLAIIETLLLHFLHSRRPKAQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWQ5</accession>
    <name>A0A6A6QWQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_507568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWQ5"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="301" mass="31457" checksum="34A658F53BDBCC62" modified="2020-06-17" version="1">MVDQTPDPDTMSRPFQLTASMQRSVYPAIDPTNPALSAAGKVVVIVGAGGGIGYATAQSWSTAGAAGIVLVGRTAARLEETAAELKTPSLVVAADVSDPAGAGSVFEKAVAKFGKVDALVYAAGYADFNMVTGTVEPDAWWGEVTNNLRGRFNMIHHFIKATNGAGTIVNLVSFGAMFVVPGMSAYSTATLAAIKLGEYLDVEHPNLRVFSVHPGIVAAEGGRGAVADHFTPFAKDKPALTGGLTLYLQTPAAEHLKGGFVSANWDVTEMEKHKEEIVEGKLLRLGFINAKLGPGGVEWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWS0</accession>
    <name>A0A6A6QWS0_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="295" mass="33389" checksum="30DB403EFAE99F78" modified="2020-06-17" version="1">MDIPTKDLEIATEAGGPSHSPKNGSSTPTRMPPETSDQGLFPYNCTAKCLGVDDIDEEFFTDPTGWSSLGREPSLNSEDNSTLDRDMWVSDNLLKTLFAVGVKMQYTGALYRPDWYEKETMKSDMAVAQQRLARWEQEGDQMKQMMNSELEALHPGKFRKLEALILTWQRRVMAEKALMGEIKLEQCRWRYYGPIICSVFQTRLPIGAMSGAEWRAVFDSTNRPEGSEGITALAQIELEDALDEHLTLQLGGSKILPEDIALGQRVLIYLSARDDRRRLRGVIKTLTSFRLETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWU1</accession>
    <name>A0A6A6QWU1_9PEZI</name>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="593" mass="64124" checksum="AA16C7F6D91EAFAF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX30</accession>
    <name>A0A6A6QX30_9PEZI</name>
    <protein>
        <submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="33968" checksum="6DC17A9EC74BA1E7" modified="2020-06-17" version="1" fragment="single">DMFIAVMGVTGAGKSSFISLCSGQQVEIGHDLQACTSAVAVYKCQYSNSRTIYLIDTPGFDDTNRSDTEVLREIASWLIESYTDKVYLNGIIYLHRISDIRMHGSAKKNLLMFKKLCGPKALKNVILATTMWDRVTPEEGARREAQLKNTPEFWGWMLNNGSRICRHTPNRDAAMTLLEQFVQGESRVTLALQSQMVDEHMTLDQTGAGKELEFEIQKERAKFAQELREVQESMQEAVRARDKESERAMRELQDDYSRRMEELEHDRSQLKISMEKLHEERYAKLERMLKQQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXC3</accession>
    <name>A0A6A6QXC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_487346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXC3"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025711410" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2495687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="495" mass="55573" checksum="7AA9B2AE9C190FC5" modified="2020-06-17" version="1">MRSIALLTSCLIALSSLCAAELNLTQSLSSKQILPANFKPPQVFKNVNLVRTTNLDKEYPREVINVIIENIDSKPQSEYYLPFESSLLSRVGGLEVKDKKAAGKLPFKVEVVEYDSYSSTQFYLIHLPEPLQPKAQQTLSISFSVLSALTPVPATINQMDNQYVQYTFSAYSPSAYTTEKQKTKVKFPTANIPDYSVLDAPNADNTEDPQKQGSTFTYGPYANIPAGAEELVSARYEFTKPLTHATLLERDIEVSHWGGNLATEERFWLTNRAATLANQFSRVSWQMTQYSNPPTSALKGLAMPLRIGSLNPYFIDDIGNVSTSRFRSNAREANLELKPRYPIFGGWKYSFRVGWDADLKNYLRKLKTGDTYVLKVPFLEGPRQPEGVEYARVELKIVLPEGATNIHHETSVPLVASEATIHRTFMDTIGRSTLHLTAINLVDEWRDRDIVVTYDYPWTAGFRKPIVIFSALMGLFTVVYVIGSFDVSIGKKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYC7</accession>
    <name>A0A6A6QYC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_525114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYC7"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="253" mass="27328" checksum="99CFC9E2538FB93E" modified="2020-06-17" version="1">MPPSGLAILIGAGPNTGAGIARILSHPSHGNLAVALLARRPEPLHDLCASLRKSSPNAVLEAFPTDTSPASLKKAFADIKAHDSFKGLKLQMAVYSVKHSSRKPFMDETYDEFTESLETYVGGAFTFAQESLKRFFADHGETPLSEGAEKKGTLIFTGTLGALRCSAQYAAYGAGRASVRQLAQTLAREMSEKGVHVVHTIANGAIADEEGPDQKSGRKMSAEAVGETYLWLHKQQPCLWTHELDMRPACEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYY4</accession>
    <name>A0A6A6QYY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_458198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYY4"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="150"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="46412" checksum="7A7833E77773D1E2" modified="2020-06-17" version="1">MGRHANPDIRRAFAEFQDESTPSKCNKVRCLHCGFVRAKNTTRQIEHLQECQAYLSSAEAQAHMRENPEGTTPIDPSMPDPNTRAILNGTHPNPNLQVHRRGPNSKRNREGLPIMPHMPQNVAPSPLVPSLTAHLLTVCGPSFQAATQTPFLSHAGCGTLAAAPLSQWLVQDGHYARGYIRFIGQLLAKIRLPQTTNSQFHISYRTMDLLISALNNIRREITFFEINVTKYGLALNNDPPSPITRAYLDLFLSASSSSASMLEGMVVLWGTEHCYRSAWTYAATFSGTLSTPSTDAHIVALHQSLIPNWTSPAFSKFVDATRALVDELANTTTSPNGKEEMLRCEEVFRQICWLEERFWPDVDGMGQEDESARLASGGGLGSLSGNGLSGSVGPLGAGIGGQSDTETPGANGQVAFSGLNGIENQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0E1</accession>
    <name>A0A6A6R0E1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_287747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0E1"/>
    <dbReference type="OrthoDB" id="5410873at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55432" checksum="5CEB31687691A203" modified="2020-06-17" version="1">MTCPLTGLPDELQIWIIENIQNSGKDGFNTLLNLSSTCYRYRSLLAPIVFHTINLKNTARSAESVLAVANNDSLKHHVKHLDFVGTLAQIDFIADPCGGNEELYCLLEDSKDAKWVYMDDLDAEEVFPTVVSDILSDLRLFPQLTMLTVRFDSDSWWGYARSNFSMLDDLEHINENTRVELLEQKEPYKALMSRTFVALSRNTNHSITALHLRLIPVVLAAYSSLGWFEFLKPIEKCTFTIKGQFNARIHIRGNYNCCPQGSFCEDCGEPPSTSATYGYPVGDTIGYRYFVSKLSQLFFDHLDSVTDLRIIAPDSGPLWHDTLCSLAKHQMPKLRSLYLERVYVCHQLGHFLAAHRDFLEDIVFQDCYGNDTGGCSWGRLLDHLSDAGPTRLQRLEIRPFEEPVFLKSRDSSLPRPGSRIDALDLDVAESLLANDPHLPAFSYAWFDEDGIIEIADYDYAVASIHGDDLKSYYRLLAIVEANRATRSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Z4</accession>
    <name>A0A6A6R0Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribonuclease P complex subunit Pop2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_558508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Z4"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000053">
        <property type="entry name" value="Ribonuclease P complex subunit Pop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="35594" checksum="5D33A630370B2E24" modified="2020-06-17" version="1">MFYDLNIPWSAADRELQRTIAFLDELGYDVVALTHTLSGKLPADLTCPIPTTLPFSTPPRLRFLRRCTLILADPSQNHRISQLSAAYDILAIRPTDERTLKQACESLDCDLISMDLTQRLGFHFKFKMLGQAIERGVRFEICYAPGILAVDGAARRNLIGNVVGLIRATRGRGLVISSEAKTALACRAPSDVINVASVWGLGQERGKDAVCKEARGVTVTAQLKRTSFRGVVDVVYGGEKPEPVTKAPALSKAEKAEAQKKRKADAMNSNGGSPAGNSAKPVPRREVKRQEKKAKTDGQEGEESTKDATSGTTVNGLTNNMPIRMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1G9</accession>
    <name>A0A6A6R1G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_456596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1G9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="384" mass="43091" checksum="492AE019D0B41E86" modified="2020-06-17" version="1" fragment="single">SQYAVLLQSIGLLPVDPSTEKDWCGRGQHSEFNKNEKDKIQQILKRQDLLGSTPNAVVESVKCRRILLARKTINCNAKFTREMAIQEVAHLQKLKHLHIIQVVGTYVVHTELAILLYPVADFNLETFMQSLADESMEECLRRIYSPRSSASKETEGSEIIRRCLALLDSFRCLSSAMKHIHDSITKHMDIKPQNILVRKLQQNRPSGLNNAYRVYIADFGIARSYSTYTDSETEGPTMFTRKYAAPEVVDRDRRGLAADVFSMGCVFAEMLAVLAPLRPDGLTRRQAFESVRGSNEYGDSSYQANISQVQEWLLTLVPNTLLNHFPLDLLCPVVVSMISSNPSNRPSAESVATSFGASETCCSDSTEPEPLEATPDEPLWPGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Q8</accession>
    <name>A0A6A6R1Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_504524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0030638">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="416" mass="46082" checksum="D26650C248096441" modified="2020-06-17" version="1">MADLNIPPLPSAPPVMISGRILVQPPLSRRGTGPGLILIVDQEELQTTLLPENTKTLDPPPLKKWAEEGFAVAQVLIHGPHPEQLISNAIKWLKSDRFHGLEPEAGWGVICKFNIDPIPLVHALDEETQHAIKAIVAYDPPISTPNFTPPTLAHYSASKSSTINPTTTTKHHIYPSADPHFILPSHPDHHPSSAALSHTRTLAFLKPLLHGPYFDLEAIWDEHMRYEFGARSVEQTMATMVDEPYVNHIPTLTGGVGRASLTAFYRHHFIFSNPDDVKLELVSRTVGIDRVIDEFVLVCTHDRVVDWLLPGVPPTGRLLNVPMTSVVNIRGDRLYHEHIAWDQATVLVQLGLLPEYLPFPYPIDGRTAGAGMRFEVKVPAGGHEVAKKLMDESAVQSNGMFENGVREVSDTSMLRD</sequence>
</entry>
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    <accession>A0A6A6R1W2</accession>
    <name>A0A6A6R1W2_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_329597</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1W2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17749" checksum="D660AFB56871BB70" modified="2020-06-17" version="1">MEACLEHRMSYSQSHLGRERLRAQQLMEDMLEERTSKHCADEGPEENNDGPSTRCGMQNSRTGRQGCLRQLPFRMWSSKPIYKCWCGHGGLRRSSPTSLADMDDTVRPMSKSAAHSLYRIAPGPCCRCLPRVVVDAIGRRAWRRESWLARSQSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R217_9PEZI</name>
    <protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R217"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025442547" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="54" mass="6135" checksum="C8338A17BB54EB54" modified="2020-06-17" version="1">MLFLMKIAFLGALLGCFNFASAGFDASSKKNIVLYWGRILFSESQYLKANRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R234</accession>
    <name>A0A6A6R234_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L domain-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_306017</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R234"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24856" checksum="3F5CCF3A250DC0AE" modified="2020-06-17" version="1">MISRSGIKSVHLSSFPPWRMGTKITCAVVIRILLMDRLCSLRLSNLSHLGDIDPSSIFTDQKSRVSCLQLHGNRFWSVDAHETKTILNYTPFLKEFQCSLPGEARPKADKGPVKMLRLFHGPDLLDLLAPLGDSLQLLELNDNFQLWPGRQRLPFVLSSFNRLRRIVAPSICFFQPGPPQMDRYELFSQLPQSLEELSVSISKHLLYPEPAQLLSDSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2J6</accession>
    <name>A0A6A6R2J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_559838</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2J6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24749" checksum="5D4339690674A77D" modified="2020-06-17" version="1">MVSFATYSAARSYGRTNALFRSIVTGNRARYGPPIKTDEYEGLKSALDLDEEHRTDLILPGSFLDATNTWVRMTAQTNAEIFARVAEHKAGNVNPPRVNPRRVRAPRRIVLPVTREPSFPATALPAAEVSTLPLARKHPVLPFFRVKGKEPAKGPEHSHESKPVEEYEHFHQSRSIEVFGQVSGSASGSTDLLEEAAGAHQVDDKPILQRLYGLNSLSGITRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2L2</accession>
    <name>A0A6A6R2L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_505206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2L2"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="268" mass="27295" checksum="BBBEDC632C03B55E" modified="2020-06-17" version="1">MSTPPQAPTPLTNKVIALTGGASGIGLATARLLLSRGATLSIADNNPTALATAKDSLLSVCSSPSQLLTTHLDVRSTPAVNAWIADTVAKLGPLDGAANIAGYHPLWGGDGTVTVAEMKDEEWDMIMEINSTGVMRCLRAQLGKAGGMGVGGSIVNVGSVAGLIGFAGNAAYVASKHAVHGVTKSAAKEVGPRGIRVNAIAPGTINTPMVRSLVTNDKGELPQVANQTTPLGREGQPEEAAELIAWLLSPQSSFVTGTIVRLDGGMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Y5</accession>
    <name>A0A6A6R2Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2Y5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="107" mass="11703" checksum="2D65E8EF5578C184" modified="2020-06-17" version="1">MGAVLSNHRAAIRTAAFLGLGFGLGVLLETVGLMPTTWNTRAAVRARGRLALGVIRVLVVPLTAALRAAATAQEPEEREVVLRLVRLQRFGKIWLVTKSWRRMSDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3K0</accession>
    <name>A0A6A6R3K0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Lanosterol 14-alpha-demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_547690</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3K0"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="17">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
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            <end position="543"/>
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            <begin position="1"/>
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        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
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            <begin position="30"/>
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        <location>
            <begin position="68"/>
            <end position="86"/>
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            <begin position="93"/>
            <end position="102"/>
        </location>
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        <location>
            <position position="308"/>
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        </ligand>
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            <position position="1172"/>
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        <ligand>
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        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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    </evidence>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
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            <fullName evidence="8">TBP-associated factor 2</fullName>
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        <name evidence="12" type="ORF">BU16DRAFT_505274</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 269.34</strain>
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        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
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    <dbReference type="PANTHER" id="PTHR15137">
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        <location>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2498770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131600" checksum="283CDC97C15A5498" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6I0</accession>
    <name>A0A6A6R6I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_501543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6I0"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="296" mass="31598" checksum="7067E10DBF0BB7F1" modified="2020-06-17" version="1">MSEPASLSPSLASRAPSASIHTSPLLPHAQDTQTLHRFALLTTWFPSGVPPGTRILELGCGQGDTTAALAHFVGPTGHITALDPAPLDYGAPMTLGEAQSLLSKGVYGDRITWVRAEVIDWLDALGEEAELFDAVVLAHSIWYMAGRGVLGQIFEALRGKTRRVCVAEWALRASLPAQLPHVFAALARGALEAQRVGSEENIQSPLAPVVIKGLAEASGWRVGRESVITPVEGMQDGKWEVGTVRAEVFAGDAERDVSDGRVREVVLSLRTAMMGALGAMGDEEIRSMDVWVADFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6K1</accession>
    <name>A0A6A6R6K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_556688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6K1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="3">
        <location>
            <begin position="63"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="363" mass="40735" checksum="B6574E790E2998A6" modified="2020-06-17" version="1">MLLRTTNPARLMQAAGSFGAVLFLLYVLFFFNNGHLPNRVRSSMGTPPPPTLANSTLDFGAILYISMPFRTDRQDALSLMAAASGLKLTMIEGVDGDTISHKAEPDGLPEAMRGSRLGCWRAHANAWRYVIDNNLGSALILEDDVDWDMNIREVMGLWNWQLKYNNTIRWGQDVKKGWGEECPYGCDWDELFMGQCANKPNMERLDMHQTYFDPNGPKLEDNLDTFKKEITQVWNMTQMDQMRITSPTYKPLCLQGYSLSHRGAMRMLYHNGGYLGLAAPIDLEIAWRTAEGKVSGYTLTPPAISAWRVGGGKDSDNDPVTNAEEIKSTGNSAGKSFGLQKSVRKNLDALLGKNYWEDMKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R796</accession>
    <name>A0A6A6R796_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R796"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="94" mass="10469" checksum="E0E04E34234FC9CF" modified="2020-06-17" version="1">MTRAQQTISIALLLSSLYLTCFLGFVPFSPKIQDEIIPVLPFWGLISFGSYLLFKLGYGVFTFNDVPEAHKELMAEIELARVDLKAKGVDVGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8M2</accession>
    <name>A0A6A6R8M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_547141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8M2"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF4">
        <property type="entry name" value="ALPHA-1,2-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2500210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="302" mass="34520" checksum="99E1EF5EBA42E6FA" modified="2020-06-17" version="1">MPTPPSAGPDTTAPSREEAWSGEPGYFKNKKEWNFDAPLEPSDETFKPEEILILTASNGGGHNAAIPNLLERICEERDSYAKLHNYTHTWLNTDKYDVGDAHPVWAKIPAIADAFYQNPQAKWLWIADSDIIFMTHSVKLEEMLLSQKAMSEKIMKGQTLFNGMKDGKSHKTKITMPEEPKISNLDILITQDHNGINAGSIFIRRSQFTRFILEAWTDKLLMEDHWLGKEQDALKHLMLEHPLIRSHVGVFPQRMFNAYAVGGDKMGWREGDLMVHLAGCWVGGDHICKERFDEFWAKRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8N3</accession>
    <name>A0A6A6R8N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_523587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8N3"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2500836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="296" mass="32061" checksum="1275BB011465674E" modified="2020-06-17" version="1">MATTTGEKKKKPSMMRSIIAGATAGAVEISITYPAEFAKTRTQLNQRLPNSKKLPWPPFGKQWYAGCTTLIIGNSLKAGIRFVAFDTYKALLADADGKVSGPANVIAGFGAGVTESLLAVTPFESIKTQLIDDRKAAKPRMRGFLHGTKIIAQEKGIRGFFQGFLPTTARQAANSAVRFSSYTALKQLAQSYVQPGEKLGVISTFGIGGMAGVITVYATMPLDTVKTRMQSIEARSLYKNSFNCAAKIFRGEGLLTFWSGAVPRLGRLILSGGIVFTMYEKSMELFDKVDPEGKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8R0</accession>
    <name>A0A6A6R8R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcofluor white hypersensitive protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_522067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8R0"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9P1"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025564837" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="185" mass="20464" checksum="035ABC003FA2FF23" modified="2020-06-17" version="1">MRFFSLLPFAILWAQPSIADLVSREFPHLIIPLKQDYPTTPFGTQYSGEITVVNGAHQVWTEISFDVPSNSARSCHLAVTIATGSQGAPWTLTGNNPSFNIFEISTAMDQFRDAWNQNTRPAVHGWVATFDVHYDGTVTMTGGDVVCNKGGLAQYLIEPNGGQNVGFTWFEEADPVHGITYEMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9X1</accession>
    <name>A0A6A6R9X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_546683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9X1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="469" mass="50103" checksum="9427D8C12069C60B" modified="2020-06-17" version="1">MPFSMRDREYDLKTVQPGSSSVYERKVAVVNRAMLDLGMGKYQWMVFGLSGLGWFMDVYWKQAINLIGPFVKEEFGIDQIAFLNVAKYAGSLVGLSCVAALVGAGSPNFAALAILAGIIGFANGGNKYVDSTIFIEFVPASHQFLLPMATVFASLAQLISVLIAWPLVTNYSCTPQLVAAHQCFFSKNLGWRYYLWTGGGLTIPMVIVRYLFHLLETPKYLLGRSRDAAAVSVVQTIASTNRNATWLTLDSLRTIDMELYTTTTTPSPTTTTTTSSALTLKHRLTPHKIPALFRTPKMALSTSLAALIWATSAASHPLTTSTLFRTLAIQAACSIPGALLAGVAAELPFLGRKGTGCVACFASAVFLFLFTRAESYEAVLGWSCAVAFSLAVAHGLLYGYTPELFPAPIRGTGQGLVGLAGEGANVGAALVAAWVGLGERSVWVAAGCLAAAGGLFPWMPYEMRGRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAB0</accession>
    <name>A0A6A6RAB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_196224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAB0"/>
    <dbReference type="OrthoDB" id="5423618at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="290" mass="32883" checksum="F016EA41582B15A8" modified="2020-06-17" version="1">MTHATMELKDASPTRTPTALATFTTPPAQLSETLPCKFCSMSLTPPRKSKTKAKLLDLSPSSYLCHKDMLPRLSKKTGLKLRPEDLHKFSWSSEPEERSMREISKRVESEGANLEISLPFETQIRGMTAQLKELRVALMAHERKFDEMAEDDTDVCIGNMVTAFIKKIAKASKNINEHGLGGGGNSTEHSTKRYTSFAGLVTAKDLEDITHLPRKYHIVLEKADQYIQDRNKGAHETEKKLARLLSSKRCRLSGEFDFWAPIFEYVYERSIEEVANKEMTPRTSLPFDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAT2</accession>
    <name>A0A6A6RAT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_522789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3621423at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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</entry>
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        <source>
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        </source>
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</entry>
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD73"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="603" mass="67849" checksum="6C21DAB4B395E761" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDJ0</accession>
    <name>A0A6A6RDJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_23301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDJ0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="250" mass="27722" checksum="CE375C25025FD49B" modified="2020-06-17" version="1">MRHLEALQRITRKMTSIFCPRSFFDPFHSAHCSGDPPIPEAPSNRTIQMPGAPLNGTIINPGPPICIVFRNCTALFNNTGPATHTNPIPPNCTFLHNCTVLSNKTGPTDYTYASPVSHSPHHLPAWGTSLIVVGIALCAAWLAYYFLIPLFLALTADEVESSSDRHREFRDFVLDPPNWPVKILAWPFVLFLRRKQTQESRDVEGGVPVEAAQSPRATRPPALPLMPSHTFNLGLDGYRGPEPPPDSWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REF1</accession>
    <name>A0A6A6REF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_522733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REF1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="267" mass="28098" checksum="16E3AC5B504F1A59" modified="2020-06-17" version="1">MSNMLNLQGRVAIVTGSSSGVGRAIALALASEGASVVCSDLTHDLRPGGYETVTTSTHELIAKTGKAIFKETDVSSPQDVEALVASAVAEFGRLDILVNNAGVFCGQNKIAEEPLEAFEKTMAINTRGTFLGMKFAIAQMMKQEPRSTGDRGWIVNISSIGGLVGLSMEPSYCASKGAVTNLTRQVALDYAPHKIHVNGVCPGFLKTAMVRSALEDAALNEELHAASPWPHLGLPEDVAKAVLYLSGDGASWVTGVMLNVDGGYCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REK3</accession>
    <name>A0A6A6REK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_448722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REK3"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2503195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="381" mass="42557" checksum="0C9B55A3B6941ABC" modified="2020-06-17" version="1">MASKQTPTPAEIASWPAPNYINPKTHRPFVLGVEIPLTAFAVLFGRFYSRTILRRTLGIDDWIMLGAAVLVLASTIMTCISTGPAFHTGYHICEALAYSPMRSLATQVFFAAITTLTKMSVCFTYLRIFPSQLNKHFCWTMICYEVCWFMGMFFGTIFQCSPVASYYSPEKYPNHTCVNQPVFSYATAALNSFSDFIIFLWPIRDLWLVQIPMKQRLGLILMFGFGVIVCIAGICRVWFMSVYYSTYDVPYNGATLTTITAIEMTVGIICGCITGCKPLMSKLFPKIFGSTHDSDNPSNGRTLPPNSQSFPFHELHGGIVKDNTFTIEYDKNPHSQSYKGNASLVTAKRSDRDDISEGSEEWIVPPQRGEIPSGVGVARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REP3</accession>
    <name>A0A6A6REP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_212286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REP3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="536" mass="60395" checksum="88AFEC48E625D1F1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RET3</accession>
    <name>A0A6A6RET3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_555105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RET3"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025482745" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="66"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2503081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="43802" checksum="7505F1F2F0AB3915" modified="2020-06-17" version="1">MRSFLSLASFFAAGALASHLGPTSDDWRDYQWSYYPENTADELKELGLPLPEIAAPITTVHEHDNYVVKLECLGCPFRVREYGVRGEHWQENPQDNSLLFNFSIAEDKHSLLVNGRQIYPLALPAKIYSFQVPANLSANVMHKMVDMRMMDSSWMVGTQYGSFEISFEHTTMMTNERLVQLLQFDITHAEIRGENPGVALLNQPKQKLIQLKLSHENIQEGLKIKSIELVEQGEKMTHAIMPCGKEAPRFTQVFRFTEWDYYGHIGTLKWTWNKTIGETGDWISDHSFLLAALAIVLIVLKRRINQRRKAKRAIDDPEAALLIVEDDEEAAPEPVQDEQQAEPKLEEVVFAEKMLDEAAPVVESKKEEGEAETTVSDESKPSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF34</accession>
    <name>A0A6A6RF34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_521698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF34"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2503074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23078" checksum="06B35AEF593234D2" modified="2020-06-17" version="1">MDRCTFQPIAPILRRVRGRTLNSAWPSLSACQPLKVAKQVAQHCSMLARQTSPRFESVSGHGVLEYWLMGRPPASNPTWLPMVLGPFSGSELKAYMTRISSEPVPEIDSEVDESFPFYHPDLGPTNIMVSDHGNSVTAISDWEAAGYFPKFLVATRPASNPAYRLIIPNTDAEKNERSKMLVEALEGMGFVCLDTAYTKWNMVKTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF47</accession>
    <name>A0A6A6RF47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_612550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF47"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="26479" checksum="8E828093C225A06D" modified="2020-06-17" version="1">MADQTPSSSVAITTSGKDYLSQSATVLADAFANDPAITYLLNVLPPSKQDPYRHTLFNAFYTGAALNGASFTEADEWRCVGVLLPPGKNVDNPLTLVQSGLFGVLWNLGIKGVWRMTHEYASKPATLKSRTLETHSKKAYYIFNLGTKEEYRGNGLSTHLIHHYQSLAAATNAPIWLEATTAYSHNLYTKLGFHTAGEIVLGQGVAGADGTVSKGGEGVKIWGMVWWPPVKKEEEEIVVYRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGA5</accession>
    <name>A0A6A6RGA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_17765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGA5"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="151" mass="16766" checksum="B2420FC20C3F61E8" modified="2020-06-17" version="1">MKILKAQNALLTNWEVAEILRDEGDEYAGTDATARNRKPPSNLKDVMTGASLYLARPSQPFNTPTATYTPAAIAGPISLVARLSPKYKLTKAEYIMLLNVRPVNLIEFEMVVDEAGARFAESEQWEILEVLKEVLGLMYEKPPEAQANGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGV6</accession>
    <name>A0A6A6RGV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_568810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGV6"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="312" mass="34088" checksum="6643292993B5A512" modified="2020-06-17" version="1">MNSSTLPACPRGQKFVAVSPLTSGFITLPEKAFVSPADSEAVRTVPSMAFLITHPGLADGSSKPFYLMFDLGLRSDINRYTPMQQVHLRNRQPYQLGPGVARQLADGGIPATKIDAIVISHMHYDHHGDLEDFHTAEVIVGHGACNMTAHGLTGKGTHQHFDPHVLPKERTVELPPVDSTSAASEQRWNWQALGPFPAAIDLLGDGSVYVVDCPGHLPGHINLLCRTGPTKWVCLCGDAFHDPRLLSGEKELGFWTGDEGHSLCIHLDPEGARESIVRLRMLQQSGGVQVVAAHDEHWYKANQAYFFPNSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7T1</accession>
    <name>A0A6A6Q7T1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_231439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7T1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="20771" checksum="E0BCFFE6152068CA" modified="2020-06-17" version="1">MQERTMNDLSAHGNRQSPYPSISVVTIPQILMLLALSRFLDATWSQKIAMTSNGVWWSRHIIGMRFIGEGGLFSRVCFCDFLFLWWGTSYLVCHTLFNGIEPLMDDSECLILLCGQSECLWGMAWSCLRQVFEGLIDATFTISTSMRQIDGFCGLRHNVRNHVLCPKVTVQACSSHLAIETPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9F4</accession>
    <name>A0A6A6Q9F4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_221241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2489030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9F4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="60" mass="6545" checksum="DAF919AD6550DF4B" modified="2020-06-17" version="1">METSEPPTCHPSLTPYFPIHALTWILLLVAGCTTCEPLLRFPDTPICDLNDRVSSSSQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAN2</accession>
    <name>A0A6A6QAN2_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_587013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="403" mass="43810" checksum="757DEA1E5030FA81" modified="2020-06-17" version="1">MGKSKAQKAASAKIRADGLKGELSAHKQNLPSLHQELGSTEWQIKSLTQQLKSLTQRRSEIHNTLSKTARLERDLDDAERILARHSNSVPVGEHRSALLSYRDQREDRQEYAYELRALTSHMTLRSGATTGPEPTQNTFRAWEGYRTLRNDGTTGPEPTRFSPYLRVKFEPGADRGGLSFVPAFPNRSQGGADFGAGTERARQSRSIPGLSQPLFDDHATAARETDRGAHDSRAVPTGPRVLGGPYMASTAPKSGVKNANLEPLGPGARASGAVRTATTNACVPPLATLKNLRQPPSEEGELVESSPSPFVPQLGLTTYPFGAPLTALAGTKRSAEHDETYDISAKRVQIEGSRSLSTIPGPFTPSSAPVPFGTAEPHHRLEILDWVPEAKDIRDEDENAWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAP5</accession>
    <name>A0A6A6QAP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_568212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAP5"/>
    <dbReference type="OrthoDB" id="3798025at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="345" mass="36354" checksum="443C73326E973613" modified="2020-06-17" version="1">MPIKFSPAAIARMGLFNINHGVSEELDSTKYFDNLQFPGATFATGSSAYNVWWKAAKDEDHCRIALMTDYSQWHYNQLGGPIQPYGNVIINAGRDGGCYFSAIPEGSNLSGTFCCGVGDCALISAGNDALTLRKGAAEAASKKEEAQTLSKKHEERSPELESETSHSFSPAARARARALVAREDCVATPQGDAFPAAGYQTLVANTQTCTTGSCSFLINKGISLSTTMTSTSDQTITNTVGASVTTTAGSDLLGFQVAVGVSYDFAIAIGKSMSEAVQNGTTVTVTNNLGQALGTTAFATFTPTYNCYMATVDCGHGVSDPLEFCNPALSEDGTTLLGDYNVVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBB0</accession>
    <name>A0A6A6QBB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_586436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBB0"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="612" mass="67524" checksum="1188A169505CD0C9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBI1</accession>
    <name>A0A6A6QBI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_472461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBI1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:aspartate biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
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        <property type="entry name" value="Asp_trans"/>
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    </dbReference>
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        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="65"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000480"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="443" mass="49068" checksum="34EAD57F3583E9C0" modified="2020-06-17" version="1">MAQHAYQTGSSPFTSSDSPKLRLSQLSDQLSPMASTHFDADVVPQAPEDPLFGLMAAYRNDTFDKKVDLGIGAYRDNNAKPWVLPVVKKAEEVLRNDPDFNHEYLPIAGLANFTSASQKLVLGADSPAIKEKRVTTVQTISGTGAVHLGALFLSKFYPGRSVYFSDPTWVNHHQIFTNVHIKIATYPYFSAKTKGLDFEGMLDTIGKAAEGSIVLLHSCAHNPTGVDPTQEQWKEISKVMKEKKLFPFFDSAYQGFASGDLNKDAWAIRYFIEQGFELCIAQSYSKNLGLYGERAGCFHFVTGASSDAESTISRIASQLAILQRSEISNPPAYGARVASAVLNDEALFAQWEEDLRTMSGRIIEMRDVLRSKLDEMGTPGTWNHITDQIGMFSYTGLTEKQVLKIREAAHVYMTKNGRISMAGLNTNNIDYFAKAVDKVVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCX1</accession>
    <name>A0A6A6QCX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="146" mass="16934" checksum="CA93163CC1327AB0" modified="2020-06-17" version="1">MFARIKRGPGHFMLLAEHWWFVLLMLVAVAYTYSSLSFFAIQQHTSASGDQHRHISALHALHALRRILRLPLRNVNRISSLAHSKHELVRRLISNMGRSGRMFFQTVVLLYPNQHIPFQKMRGRVRERSLYTRALSPLGDCHVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCZ8</accession>
    <name>A0A6A6QCZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_553223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2489959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23330" checksum="82C1D7F66AB721F3" modified="2020-06-17" version="1">MCWPARPSEGQPLGPTSKYAPGPGTHIYESVIHASISGPVVSTHVPPTSTNTNKSSKPLPTLSITRNPPPTSSSFLRGGASVLPEVDSIVLCRITRLGARFASAEILVVGELVCREPFSGMIRREDVRATEKDRVVIREMFRVGDVVRGVVLSLGDQSNYYISTAKNEYGVVMAWAHVEAGEGAGGAAKRAMYPVSWKEVRDPVTGVVEGRKVAKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDJ6</accession>
    <name>A0A6A6QDJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_424020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="419" mass="47664" checksum="5F6C5D225818CB8B" modified="2020-06-17" version="1" fragment="single">APLLRDTKWADGLRGIAAFFVVSSHLTLGYVAWLDHPTRTKDTRLAFYNLPFIRVFAQGSPWVITFLVLTGFVNAIKPIKQGRAGRVDAALSGLASSCFRRSARLVLPCTIATFFSWIICEAGGYKIGNMVESAWMVDTSPLPSTSIQGAICRLLSSIYTTWATGRNVLDKNQWAMIFFLKGSLALYVLLLATVRATARYRMLIFFVMIMFSWAKKDTHMGLPIYSGALLTEVSMIPGIINFSVNRRLVYRLPPFFMVVFAWYLISYPVNKPSWQPWSNALWTLGKLIFPKGAEYESFFYTIAIALLVFSIILSAKLQQIFSHPVLLWLGAHSFPIYLIHGPLLRSFLNWVLYAFVAPTLYQEKDDKGNVVRQYERFPIPSALKFFLLLPVFYAVLFVLAHFWLQKIEPRCASATKWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDM3</accession>
    <name>A0A6A6QDM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="321" mass="36057" checksum="3E29B8C125C491F2" modified="2020-06-17" version="1">MPAPYNLRNADHKARKEQEFKTAPAAPNGTRGKHTANTYKAPSHQPALPNFQTLGMLGQVPLTVHPTARNKWAGYREKPSQFDIADNTTTIKVEPSSQDVPFEKDDRVVSVWKEGSQLVDAQGRPVELATEEDEGVISLGISQIDLQDRTDITMPDAESTPKGRFDGVEIQDTYFESDDEEYPDEDFQTAADGLAKTEVACSRHCDEDMATRLHAIAPRTEIAYRNCILDGIERIFLLEQAKAEKYAGYVVRPLVVIATDHARYLMRDRDNDIEHRGLDVYYVDSQTEWAKWAVKAAKAGLFHLPRGQCGSLRDQVLDRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDS3</accession>
    <name>A0A6A6QDS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_160830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDS3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="25366" checksum="910DB79DD80D11E9" modified="2020-06-17" version="1">MAEVLEDETTPRDRQPDQLAQQPHRHLRPEASAVGGLVEEDSVAVEVAAAASEAALAAEEIVASEVADLEVTEVGMEDEAALATSRTASAAQEHHRTAHPLALVEEAEVEGSQEATEAVRLTPTAADTVDAPTTTEAVSVTADRAAATANLSASGDHETATLAETGTEAIEVAGIGTATERVVVGMAEMTIPGSAHTMATTTTIPEANADTERLDSAEQRMGLSQWVFSVLSDFNFLPFRHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDV5</accession>
    <name>A0A6A6QDV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_531069</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDV5"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <begin position="111"/>
            <end position="212"/>
        </location>
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        <location>
            <begin position="238"/>
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        </location>
    </feature>
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        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
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        </location>
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        <location>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="689" mass="77543" checksum="FFD597B56434E80F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEV9</accession>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_586140</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="886"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115375" checksum="13E8D78FC72E5C1F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFH6</accession>
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        <submittedName>
            <fullName evidence="9">Zf-CHY-domain-containing protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0016567">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR037275">
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    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13639">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
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        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
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            <begin position="25"/>
            <end position="53"/>
        </location>
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            <end position="153"/>
        </location>
    </feature>
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            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="636"/>
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            <begin position="27"/>
            <end position="36"/>
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        <location>
            <begin position="44"/>
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            <begin position="117"/>
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        <location>
            <begin position="663"/>
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        <location>
            <begin position="674"/>
            <end position="703"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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            <dbReference type="PROSITE" id="PS51270"/>
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        <source>
            <dbReference type="EMBL" id="KAF2490750.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="710" mass="79569" checksum="0D85203EE57572E0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFL6</accession>
    <name>A0A6A6QFL6_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_516752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
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            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="138"/>
        </location>
    </feature>
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            <end position="168"/>
        </location>
    </feature>
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        <location>
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            <end position="200"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="254"/>
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        </location>
    </feature>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="440" mass="47141" checksum="0DAFCD4520CC13C4" modified="2020-06-17" version="1">MKTSRSSQGHGSHATGPQSELGVIATDGHKHDTISPHPPANNNLPPNGGTRAWLQVLGGFFLFMNSWGIVNTYGVYQTYYERNLLHQKSPSSISWIGSTQAFLLIFISVATGPLFDLGYFIPVLLPLGSVLIVFGMMMTSVCNHYWQVMLAQGVVIGLGCGCLFLPSVAIVSTYFTTKKAFATGIVAVGGSVGGVLYSLLFARLQPSIGFAWATRTIGFIALATLGISAAVLRVRVLPPARRRLLDHTAFREIPYTVFSIAEFLGFIGIYIPFFYIQSYALDRGVNPHLVFYLVTILNAASIFGRLGPNYVADRIGPLNVLIPCCIITALLGFCWIAIDSTAGIVVFCILYGFFSGAFVTLPPTIIVGLSPSLSVLGARMGMSFSLAAFGSLIGTPVAGVILKKYGWVGLQAFCGASVGAASIAIIVTRMKKTPRLMEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFS2</accession>
    <name>A0A6A6QFS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_552760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2491255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="300" mass="31381" checksum="0E7938E42C499056" modified="2020-06-17" version="1">MSDGKSNTESLTSSKLFDVSHVTAIVTGGGTGIGLMITQALVANGAKVYITSRRGDVLKQSDKQHDSGSGEIIPITSDVSDKKDILNLVEEISKKEPDGIQLLVNNAGIARDQNTQFSEAGEPDMSSPTAISEHFLKSTPESWEDTFRTNTTAIFYTSMAFLPLLAKGGKKTPGYTSSIINVTSISGAMKGSSGGQFAYGTSKAGATHLSRALAATFAKTGVRVNVIAPGLFPSEMTTGESGEDNKSVINKELSNPAGRPGKDTDMAATVLMLAGKGGVFYNEQIMYPDGGSTLVLPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG74</accession>
    <name>A0A6A6QG74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_594306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG74"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41171" checksum="0E795D8A9D6365A2" modified="2020-06-17" version="1">MSSNTNAISSSEPANETVAFAVKQRRQELRQTYPAYATVAREVERGIARNPLRELYALVDRLLVENENASLRERALREEEEDSEAATTDAENNDTATIPPWSKGQTMAYLVIQRRLNLKRTSAVTFTPPHRLFGGRQSFASATYKSARTAKLPSSAKHQLHKRQTSSTSTNMSDTPRTTSPAASEPQNATVAFVVEQRRAELRRTSPVYATVCREVENETATGIIADLHALITTLLVQSENRAFRHLAHDPAGDFDNLEPVAASLEETLDLRVHLAVGHGIRNGMTARETLERIAQTLRQYLEVVEEEELAEHELAGFVAVNRTLAVVVVAVLLPSLLLNAHLYFGSERVLGVIRTLLGVLMAAAVVRNLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGF7</accession>
    <name>A0A6A6QGF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_469617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGF7"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="653" mass="69885" checksum="1DF2AAB5102A942A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGV6</accession>
    <name>A0A6A6QGV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_565162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGV6"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="381" mass="42411" checksum="3F9021A84E9A82E8" modified="2020-06-17" version="1">MFLYACLYWIQHLQKSGRQLHGNDQILQFLQEHLLHWLEALAWMDKISEGIDAITTLESIALLKNCSSLLSFSHDILRFIRSSRTTIEQAPNQTYCSALIFTPALSTVREQFKDCIPQWIQRLPKVEDDWNALLQTLEGHAAPVNAVAFSHDSRLLASASCDKTVRLWDSRTGAVLQTLKGHLDYVTSVAFSPDSKLLASASRDKTIRLWDTQSGGEVQILRDHSDWVWAVSFSPDGKLLASASSDRTVKLWDAKSRVVLWTLDSHVGYVSAVAFSPDSKLLASASRDSTIKLWNTQSGEELRMLKGHSDWVMAVVVSSDGKLLASASSDGTIKLWDIQSASSEGMENLWDTQSSEALQTLIGCSDWVVTMTFSFDGNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI34</accession>
    <name>A0A6A6QI34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_565403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI34"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="510" mass="56879" checksum="C9626F0AC24092EC" modified="2020-06-17" version="1">MESALAEPFSSRDMNASPVKVKHRRKRVGCLCCRLRKKKCDEVKPTCEGCERNFLICTWPLPNKKSGNGSNRDGVERITCPDAQTASQCDAIFSTIAEPTTILEDRSHAITSPAETRALLSVRSPPVIFVSPALQMLCEFYLRKTANTISILHDEVNPFITHIMPMAASDDLIMQGVAALSGAHLCKQSDASADVKTLAPTHEILVIRGLKFGLTRYRKNPENALSLIVAILFLCLTETVKGETNSNTLHHLKAARALILQWITIAAVKHDTGLRTLITELYLYLAILLSVPLGRDPYHQLVYEDSKLLFSYLPRDHTGPLFGCARDLFELIPQIFQLANEKQAAHDTSHSQFRSKEAAIASLLQEILVWKPTKDVHDDTSRGGKIYQQALIILHYTSFAIFVRAPVDILRVIDEALSIAGNELNHIPLDSPILTTLTWPLAVLGSCATRPEHQDLLRQRITGMCQTLRMTCFEQLLQVLETLWASSRHQNGMAAFEVVMKEMNLVVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIF6</accession>
    <name>A0A6A6QIF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_127886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIF6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="79" mass="8910" checksum="0642C9786F66818B" modified="2020-06-17" version="1">MSHTIPRREAVQRFNFKGAYFTWLVIVLSMKSSLGNRTGEVYLIHHAVGTRAIRDAKLLPHWALGAQCKSYPGGHSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIJ6</accession>
    <name>A0A6A6QIJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_565570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIJ6"/>
    <dbReference type="OrthoDB" id="5335493at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="402" mass="45841" checksum="68FFAD13E513CE82" modified="2020-06-17" version="1">MPPLSFAQALKGRAGTTSANEPSIKYLEEAVEKEVHAFNNLNLLNYLNSVVVKRLPNVLQRNIFFNLEHAGRNEALCMRLQQSKVEARVKGSWVSIQDVLATRPIQWQDFRLLALPAELRNLIYQNLVGTVVYLYQYGGHHKDVKTTYWFESSSPGLLNSEFGATGTHVRTAPPKVRWISIRHHVIDGAAPLMGLLTTNKQVNNEANDLLWKEMDFRFQTLFYDNDDIPSNLERFGTALSTVHRNTIRHITIQSSPDELRRAMRLFASNPKPFHQFLPSLKLEIRLPHRRKYSRGWDDGSDWGLKLRCWRGVLGEILWSGRTALAHFDDLQLTGCISLELRSKFLQLLKDIKLGQPSNIAEEDIRGLCGLVGLDDHHCTTRTSRACRDDWCVCQGVRAPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIN1</accession>
    <name>A0A6A6QIN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_467039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIN1"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="430" mass="47443" checksum="2D7B88715A82A457" modified="2020-06-17" version="1">MADLRLQNLKVGATAGAESPTTARPLDFDDDDKDGSSTPAESLMAPPPPAKSPKPRVSFQDEEAPPAKPPRPMSPQAQAENTLIEAFPSVDAKVVKAVLVASGGKVEPAFNALLSMSDPDFRAEETPPPQPPRPRQPQSQLEADEQYARQLAQHYQSGAPGYGSRERGDPPLPQRRQELGLKPNELYDDREHSFFDDDLPVIKENMRKGFLETQTTVNKWITTFRKKLDGDDEESDIVQPGSSQNQRQNYGPSQSEQLYGIRKSSEARRSGDRERYDADNRVLGDDFEALELRDDEAQHSRSQRPLANPDLFKPTPVAPPQTGPVDEVEARERQTTSTQGNKGKKWQPLTSVAPHPEPEDHDPFSLGDSDEDEAKAKDIKAEDTERLKKLASESEAEKGGESGKVLKPAERSGSLGTRDQAAEEILKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJA4</accession>
    <name>A0A6A6QJA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_127768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJA4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="15511" checksum="787A3D6CBEC12194" modified="2020-06-17" version="1">MEGLLNIIKIHDVAFSGWLAGRSLVILITISSVLQIAFIAENAANCFPKFPYSTMTVVLSIDISATTLLLDPIKRVIGPCLNHLNYFTKRSLCFTLFTVDCRVLFPSEVVKQFLLLPTTTPIAKRHSLRHCAAWFSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJV4</accession>
    <name>A0A6A6QJV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_439454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJV4"/>
    <dbReference type="OrthoDB" id="3920378at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="211" mass="24164" checksum="605A2863E92B2925" modified="2020-06-17" version="1" fragment="single">GALNGGIFIVKSKSSGKLYIEKRFTSRDVRELHAKREVAYLRQLRGHPNIAQLKAFELDPRDTPRMYMEFYELGALDTLIDRYENKQVYLPEGFLWRVLLDVAKALRFCVYGIHKEDDKVDPDWDSILHRDIKPGNIFLTDTGGLYPRSVLGDFGCGISMSDITTGLAKNEQVSRQARAFSPPECPKYDRRSDVYQLGLVIHCLARLLRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK77</accession>
    <name>A0A6A6QK77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_529756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK77"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2492426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="39021" checksum="A88DC1C856E7F99F" modified="2020-06-17" version="1">MPTFKIVVFGGDGVGPEVIAEAVKILKVVEKGTPDVKFEFEDHLFGGASIDANGTPLTDETLAAAKTSDAVILGAVGGPKWGTGAVRPEQGILRLRKELSTFGNLRPCFFASDSLVSASPLKESVCRGTNFNIVRELTGGIYFGDRKEDDGDGTAWDIEPYSRPEIERVVRLAGRLALAEDPPAPVWSLDKANVLATSRLWRKVFEEVMTKEFPNLKHGTHLIDSAAMLMVKNPRALNGVIVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKSKVFGIYEPIHGSAPDIAGQGIVNPVATVLSMSMMLKYSFNLPALAKKIDEAVKIVIDNNVRTKDIGGQAKTAEVGDAIVVELEKLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKQ4</accession>
    <name>A0A6A6QKQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_563908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2593732at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="557" mass="62500" checksum="8D2C4EDF4B86E274" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLF3</accession>
    <name>A0A6A6QLF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_528620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLF3"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="524" mass="57237" checksum="99FCEC27F21387D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLL7</accession>
    <name>A0A6A6QLL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aflatoxin regulatory protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_563924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLL7"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Aflatoxin regulatory protein" evidence="6">
        <location>
            <begin position="134"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="35834" checksum="B560D9A1C1E189CF" modified="2020-06-17" version="1">MELDLRGIIPDFGQIGPATTPADIDVSSSSFLEGFHVNAALEDNEGTLIGMNDMDYLFSFHDRLPDQLNHSEQPFFMDVSYNLTPLPSPMPPKPCFFYPQLHSRAQPEQLTALESMNLLKPSASASNLNGVLLSCSCVSTALTLLEELAVDGHDTGTQSTSQRLGFKRRCLLTCATLLGCSECSKIPRFLMLLIQICQKAVDSYVVLAKILQEGKSLHGHLTGLSYPESFQQVPVSKTAPYPMYNAQDVSPTHGAGPSMSLGEYDVTSEEEMCVFTSLATMQLAKWKGFLGQLSERCASLGLKSHMAMGVQLERRVQMQMHELSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMM6</accession>
    <name>A0A6A6QMM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_465083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2493645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMM6"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025667883" evidence="8">
        <location>
            <begin position="19"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="552" mass="59410" checksum="D86CC765698C5FB4" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMT6</accession>
    <name>A0A6A6QMT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_52284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMT6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="76" mass="9014" checksum="94BC3E3DA1BAFD0B" modified="2020-06-17" version="1">MAYTSCQDSILLMREYFNVIFLLRVPFLVCLTVLDERWGSRLMTLTLRYLFREEFNGASGRPSFERIISRTTQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QNB7_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2493732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QND0</accession>
    <name>A0A6A6QND0_9PEZI</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="7"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        </location>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="30"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="53649" checksum="02B5839B5A7F3CD0" modified="2020-06-17" version="1">MQRILRLFGNAQAEPENAQPPRLHANTPVEDPEVEHVDEDDEDEEDDEGEEDDEDEEHDLRYWGPIKNISNQALIDLTLSILDPGKQLNAENFLVLDQDEGTFHCVWIVETPTREKIVIKVPATGHADRWTPEDAVNIKTEALTMAYLAKHTKAPVPAILGFDCTFSNSIGAPYIMMGFVEGKPVHKVWYKHQHNIEEIRQNILTSLAKAMNEFGKLEFNKIGTLHFDGDQDPVVGPTHTFRVPKDIKDHPEDLGIARELKTIPAFSTAKEYYEAALQEKEAMSRIDDRVRGIHKILRTAFAMPPFTKVDSAGKSTGGETFVLAHADLDLQNVYVDDDGNVTGLIDFDGIKTVPRCVGSAVPMWLRHDWRPQYVWPGEEYTTLSPQELDRYRNFYAKAMLEVAGEDSDAKFTEKSAMFTALHDALYGNGSAADAADKVLESAFPRTHSWTFTTQLGEGGWKEGEEALRERLQNVLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPR6</accession>
    <name>A0A6A6QPR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_562055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3946185at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="622" mass="69074" checksum="8D10584D17DD95DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ34</accession>
    <name>A0A6A6QQ34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_592847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ34"/>
    <dbReference type="OrthoDB" id="3799440at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="343"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="843" mass="95264" checksum="0A607564A574A01F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQH6</accession>
    <name>A0A6A6QQH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_44664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQH6"/>
    <dbReference type="OrthoDB" id="3905517at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="55060" checksum="6FEDF6C501E66EE0" modified="2020-06-17" version="1">MVFRGRPSKACERCRARRLKCDFMIPTCGQCTRASVACSGYRDTQQLRIRDESLTVAKKVFVVQNAHPVKPQFLPLSIDLQAREAFFAFYVTSKCWNFLRPYSHPTDSPEHLTLAIEAVSLAYLWHQVNSDTALANARERYVLALRMTTKILKSPKEATKEATLLASLLLDLFEKITDIEPRNTKSWTSHVDGALSLVKLRGLEQFQNRSDIDILLRLSSNSLMSCLCSDSPVPDELMAIQAHIANHLHTLDPKLRLSEVMVDYGRFRNDAKRGVLSNEEYVRMAMKLDERLLTIDFELPARWDRITTFTECTSDRVFGSHYDTYSDPKICLARNLFRVMRTLVINSLIEHSLAAPEHSQLLAAALNNIEILAREICASVPPYVDCNGAVQQRHFASMDIPVHTGHLHTHDHLIDCYMLIFPLYVAGLSDTVPGMRSWVIKQLHYISSHFFIRNAQMVAQLLEGEKHVSAWEVYAMLGSYAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQS7</accession>
    <name>A0A6A6QQS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_487668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQS7"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="35"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="391" mass="43902" checksum="CF640A8A4C947202" modified="2020-06-17" version="1">MEAIPTFRVMDQDGVVINKERGVGTTDEEAVTLYTKMVLLSIMDTIMFEAQRQGRLSFYMASAGEEAITIGASSALDPSDVVFCQYRETGVFLERGFTLEQFMDQMFSNHKDVGHGRNMPVHYGSRELNIHTVSSTLATQIPHAAGAAYALKMQNAQRPDLPPRIALTFFGEGAASEGDFHGAMNIAATRGSPVIFLCRNNGFAISTPTKDQYRGDGIASRGAGYGIETIRVDGNDIFAVRESIKEARQKALEDGGKPILVEMMAYRVGHHSTSDDSFAYRGRVEVEDWKRRDNPLTRLRKWLEGRELWDEDKEGELRRKLRKDVLGAFAQAEKEMKPALKYGFTDVWENVTEEQKSQVTELLGILETYPEEYDIEHHEGGLDSLRELVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQY2</accession>
    <name>A0A6A6QQY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">haloalkane dehalogenase</fullName>
            <ecNumber evidence="3">3.8.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_528576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the haloalkane dehalogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQY2"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01231">
        <property type="entry name" value="Haloalk_dehal_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023594">
        <property type="entry name" value="Haloalkane_dehalogenase_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002938">
        <property type="entry name" value="PRK03592.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="35229" checksum="A9E8C31F7FBAB92E" modified="2020-06-17" version="1">MANPPESSISSEFPFMLQNIDVLDSKMAYIDTKNTKITTATAIFLHGNPTSSYIWRNIIPHVSPKLRCIAPDLIGMGKSGKPDIAYRFVDHARYLDAFLDAIVPTGKVVFIIQDWGSALGFHWASRHQDRVIGVAFMEFIRPFATWDDAGEKQGQETFKAFRTPDVGRKLLIEDNLFIKAILPGGVVRGLSPEEQAYYQAPYLDEKSREPVYRWPNELPIEGFPADVYEIAEKYHDWLLKSDVPKLLFWATPGVFVRDEQAKWYSENLKNLKTVFLGKGLHYLQEDHPHRIGSEVAEFIDTLDSSFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQZ2</accession>
    <name>A0A6A6QQZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_48838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1611" mass="180133" checksum="5C14CF5DBFBCB571" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRC8</accession>
    <name>A0A6A6QRC8_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="385" mass="42384" checksum="1FA92EAE09F7B54E" modified="2020-06-17" version="1">MFDNIRSNTQGISNSHYDTAKQLKGTILPIFERLHTEIKNKQKELTKGAGKGSKLVDKARNTTQKHIELLGQHTAGYDSTGGKMSATEDPYVLQRGVMHRLNKQIQEENNNRQDLIAVQNSFAQFEAHVIAVVQQGWGSFNQVLAAQAEQTKAMYADMTMTTQSIAPDFEWNGFIHREEGILINPSAPARSISNISFPNQNHKATQPMIAGSLERKGKLLKKYDTNYYVVTPSKFLHEFKTDDDFAKDPTPEVSLYLPDCIVGACSGQKFNVKGKDVSKGKVGNTFSMSHEFAFKAHTPNDANQWWEIIRAAAGQTTNELPDSSSPNSPISPTESRQPAPLNTQNLAMEKETLHQTPSSAHPASATPASAISQPKSGIEGKPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRJ2</accession>
    <name>A0A6A6QRJ2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_81154</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025579430" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="68462" checksum="C5BE00ED5B2D84BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRR4</accession>
    <name>A0A6A6QRR4_9PEZI</name>
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        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="573"/>
        </location>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="69418" checksum="4D788C06042C194E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSA5</accession>
    <name>A0A6A6QSA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_550722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="687" mass="75647" checksum="D996E203464292D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QSQ3_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_539629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2495715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTJ1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR048680">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495715.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="803" mass="88354" checksum="E1AF4A23E852109C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2494517.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="353" mass="39619" checksum="1EDD57033402763B" modified="2020-06-17" version="1">MADKALKAKVSAAVEEILSNWDCTVDRILPNDLHPRVPTAGGNKRLIGEVAPMLPPSDWSKNFVFPLREISKLTIGKMPMGLQFLQVAVLERQSDTSHNYRKVGELLASDVKRAVELVKKEQQDVNALADTLGSAGIERNPAGKGKEQAAGSPMVPDSSHLRCTVNPKMAREFRQEMAKKEAELEEEEVEPLVLIVAIEENWEIDIDDCLSRTPLDVRPFIHKKPKERTQRQPHPLSPPPIAYDPNWEATWRASVPGPNASKKEMKTYMEAQAVVMAADPEWDFKNPMDWDLLLLHLLTILSKVTNGQHRVVQMALVEAVRVRQKTKYAKKTDELQPGDVIRVLKDVLGQVLT</sequence>
</entry>
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    <name>A0A6A6QVJ7_9PEZI</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Gonzalez J."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVL9"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="286"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="818" mass="91024" checksum="F22B94B561D448C9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVT5</accession>
    <name>A0A6A6QVT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-repressible gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVT5"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9067" checksum="4DC42242690E270D" modified="2020-06-17" version="1">MLCPSRSESPQRLLTPHLRNAANSASETIQQGVSGTSKEANKQVAKDGDASLTDRATAGKDALSDKASEEKHAVSSLNNPDTYSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVV2</accession>
    <name>A0A6A6QVV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_617726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVV2"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="202"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2496254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="300" mass="33040" checksum="CBBCED7D4C67B3F8" modified="2020-06-17" version="1">MSTDKPLPFVYQFAAGAVAGVSEILVMYPLDVVKTRVQIQTGKGVGEDSYNGMVDCFRKIIRNEGFSRLYRGITAPILMEAPKRATKFAANDEWGKFWRNQFGVAKMNQSLSILTGASAGATEAFVVVPFELVKIRLQDKAQAHKYNGMIDVVRKIVTQEGPLAMYQGLESTMWRHVLWNAGYFGCIFQVRALIPVAKDKKGQVFNDLISGAVGGTVGTIINTPMDVVKSRIQNTAKIPGQVPKYNWAWPALGTVMKEEGFGALYKGFLPKVLRLGPGGGILLVVFTGMMDFFRSIRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWJ8</accession>
    <name>A0A6A6QWJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2496805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWJ8"/>
    <dbReference type="OrthoDB" id="10479324at2759"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="629"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
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        <location>
            <begin position="656"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="749" mass="83608" checksum="6A266857BBFFF62D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX90</accession>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">BU16DRAFT_437020</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5392779at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="58" mass="6881" checksum="78F6875E126E1F4A" modified="2020-06-17" version="1" fragment="single">DPAYVKRRKVRKGTRSCWECKRRKMRCIFDTEAICKGCRRRGSKCISQEFPEDVLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYR6</accession>
    <name>A0A6A6QYR6_9PEZI</name>
    <protein>
        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_354995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYR6"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="43"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2497262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="596" mass="67808" checksum="3AFEE19F9F981FE8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYX5</accession>
    <name>A0A6A6QYX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_526026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYX5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="52" mass="5774" checksum="698FAF81F5140995" modified="2020-06-17" version="1">MVAREFSASVVLENQVGLVCCGCARHWFLQRGLSACPNCGHSWCSSCQAWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ42</accession>
    <name>A0A6A6QZ42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_571456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ42"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="59827" checksum="DF6D44399ADB6E7B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZF5</accession>
    <name>A0A6A6QZF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_525425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZF5"/>
    <dbReference type="OrthoDB" id="3932237at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="257" mass="30236" checksum="35BD24C821B0E442" modified="2020-06-17" version="1">MAHWDMSNLTTVEKRLDAALEDASKNRSEQHKLAGLEWEASKTADINRVSFLDLSLELREMIYTEALICEELTCTWLPEDPAQRYVNKYNPQNQPNVALFKVCRQIRAEAQKIYYSSNTFTTRLMFAFEQAGRYAMMVPAPYKDLVRQVHYRFDFRHLLCRPKEFPIYTSMIRKWFPSAHVEIMLWEYPSSVHFLNVTSREENFQSERNFLKTLTGWDKIPDGFGITFDGVGFYSHKLKDIMVDWKPLLRAKDGAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZG3</accession>
    <name>A0A6A6QZG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_457713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZG3"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
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            <begin position="149"/>
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        <location>
            <begin position="182"/>
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            <begin position="285"/>
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        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
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            <begin position="217"/>
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        </location>
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        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2497845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="457" mass="49682" checksum="72806D0AF4241B50" modified="2020-06-17" version="1">MPGSPAASWPRFRARLKSTFEGADPRVCAAFWLFGLINNVLYVIILSSALDLVGPSVPKGVVLLADVIPSFLTKLVAPYFIHKVPYQIRILVFVALSACGMLLIALTPASRDGKTVAIKMSGVILASLSSGGGELSFLGLTHHYGHFSLAAWGSGTGGAGLIGAGAYVIATTTLGLSVRTSLLAFSFLPVIMLISFFIILPLGPLKAGAKQAEYERLDQDQSPTISAEESDSDTSPNASPEGEHLLSSSMHSASGRSFTSINQSRSRTRNAWNSLKANLARSRGLFFPYMLPLLLVYVAEYTINQGVAPTLLFPLKSSPFEHFRSFYPTYNAVYQVGVFLSRSSTPFFRVHHLYLPSILQVLNLILLTSHALFDFIPNFYIVCLIIFWEGLLGGLVYVSTFAEITDNVPKVDREFSLGATSVSDSGGICIAGFVGMAFEVWLCNWQVRHGRNFCKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZR1</accession>
    <name>A0A6A6QZR1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_606815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="494"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="455"/>
        </location>
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            <begin position="274"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="53222" checksum="D5D9EEEF1265A6AD" modified="2020-06-17" version="1">MSYYDNASWPAPGRQASWEQQQPPPSRSGASSTVNRDEIVAFSAQFEEVDRAAENLAKSGKSFGVGTPGPGRRDSMPVTPGRPYSEYGGPQRHHSVSEYDGIRSHSASNLQGYYANQRFAPRPNDADQMAQAKRRMAAQRERELRNYHQEQQYHRRLLVNGSGVHADVSGAKSDRSMSPNAMSEEDRRELIARQHRALYGDGSTLYGPEGTRTSSQDARVATSSAGRGASPLAFDPFGMQSQSASGEGSVQMPSREQMSSKDASAGAQQERATSNSSPSSSQPNNSFSLFENAQQSSRTSNSSPGGSPPRQGAKATSGVAPIGTRPTQNQAPPPGAPLSKRSTTPLPSPLSYSYNASEQQNNSNDHNSSASSNPSSSVADKGVGLGWGSNSGSSPRPQSPTNPPSTGSSTARTVSPRPPGGPATVMRRKAAQDRAEKTANLRPSSTRAAGAGGSSSTMLRLYTDESPGLKVDPVVVMTLSVVFIFSVVALHVIAKVMKKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZW2</accession>
    <name>A0A6A6QZW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_483314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="570" mass="65017" checksum="A1ED7A6DFB2B5221" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R146</accession>
    <name>A0A6A6R146_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_537538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="MU004186">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R146"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    <sequence length="392" mass="44253" checksum="3E79F89354268743" modified="2020-06-17" version="1">MAVCVVCEDEEKEETPLRETGCGEHSMCDACLEQVFRLALTDESKYHPQCCGLEESVLLVDDFEQYLPFELVFDYRVKEREYSVLARSRTYCGSKTCGKFIHPDNYKQDPADSALCDACNQLTCTKCATLMDSKGPHTCVISEAEVKFQEAVKEHKYQRCTECNFVIELTEACNHISCECGREFCYICGKNWDGYHECPSYGHPVYDDEGYNQILPFKDGFHKDTGLNRNGFTRSGQIDHDRFGETGFDDQGFDREGRDANGRNRGGFDRDGFDENGFDAEGRDADGLDAEGLPMMPADMLEEHRMAMEARNIELGNFQAEPEEEEEESSESSESSEEDEGDEDEGQQGQEPIAEAAAETAAENEEMDVDNVEGEGNREEEREEPRGEVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R2P7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">BU16DRAFT_261039</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
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    </dbReference>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="975" mass="108787" checksum="729AFD7FC4518744" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3D4</accession>
    <name>A0A6A6R3D4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_524904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3D4"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="167" mass="18792" checksum="47BFDFA02EB2D4B5" modified="2020-06-17" version="1">MFFLYELEKTIQLHPSFFGPLIRSHIHRELLAKEEGSNTGKYTIVCILDSFEVSEGQVVAGTGHAEYTVHYKAVVWRPFRGEIIDGVVSSVIRSGFFVECGSLQAFVGRSMIPSEIKYDANATPPQWTDNAEQIIEKGTQIRIKIKGLRSEVDKMFAIGTMKEDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3Z1</accession>
    <name>A0A6A6R3Z1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_523924</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3Z1"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2499441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="159" mass="17422" checksum="7DE8A94C189E2363" modified="2020-06-17" version="1">MDQAKLARMQASVRIGDGKGTPRRKVKKVHKSAGTDDKKLQTSLKKLNVQPIQAIEEVNMFKSDGNVIHFSAPKVHASVPANTFAIYGQGEDKELTELVPGILNQLGPDSLASLRKLAESYQSMQKEKGEDGEKGEDDDDDDIPELVEGDNFESKGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R458</accession>
    <name>A0A6A6R458_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_274112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R458"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="117"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="557" mass="60334" checksum="05A59E26C1CB8553" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R486</accession>
    <name>A0A6A6R486_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_535880</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R486"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025378725" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2499541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="181" mass="17404" checksum="66803B87327968E7" modified="2020-06-17" version="1">MRFSVVAIVAALSSLSAAQSLLDQLPQCARTCVGQNFGNCKTLDIACICGNTDLIANLSCCVSKSCNADDTQTTIQFAAQLCKTYNIIVPSVASCASSAASTGTLSSTASAASASSAASASSASSAASESASVAAKISSAASLATASVASATPTSTGIAAVNNVGMGVGMGAAVAGLLAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4B1</accession>
    <name>A0A6A6R4B1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_300122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4B1"/>
    <dbReference type="OrthoDB" id="4117770at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="624" mass="66704" checksum="F865DF0DEC4BE564" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4F6</accession>
    <name>A0A6A6R4F6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_558698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4F6"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="71"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="344" mass="38377" checksum="E44DE0283B32AE6C" modified="2020-06-17" version="1">MPLLSNLKAYLFGIYASFTTSNNPVNSTLATPTGEPPKCRFRLDNDSSDTLTLPDGRKLGYAQYGSPTGRAILYQHGWPGSRIEAAAYDDLGLQIGARIIAVDRPGVGWSSPHANRALLDLPKDLEHLAAHLELENYSVLGVSGGGPYALACAAALPPEKLKSVSIVCGMGPPDIGMRGADWAHWVGWPWGIRYAPYWLGRWWLRRQPGGRLDLTDERYLELMLQPGSDLQKSHQRDLDIMTDTDFLRLSVRSARETYAQGYDAVWADGKLMCRDFGFRVRDIRADLPVQLWYGKYDTFVPLVHGEQIAVRLGGRARFRVKDEAHAGIQVHWQKEIVEALISSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4I7</accession>
    <name>A0A6A6R4I7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_524902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4I7"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="323" mass="34505" checksum="00EE44594D972E61" modified="2020-06-17" version="1">MANATRKELIGKVYKMIPPMLESFHKGQLGRVAVIGGSEDYTGAPYFSAMASAKLGCDMSHVICEPGAGAVIKTYSPNLMVHPYMRQSKNLASTESLDSVASEVVGMLSRLHVVVIGPGLGRDKLMQDTCARVIAEARKQGIPFVLDADGLFLAQTRPELVDGCKECILTPNIVEFGRLAKAKGVDVAEGKPEELCARLARAFGGVTIIQKGAKDYISNGTTTLVSEGEGGLKRSGGQGDTLTGSLATLLAYRKAYLDKIWEHEGDLGSEETLALAAYGGSAITRECSRLAFKEKGRSLQAADLTEHVHQAFLNVIGEKESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4L8</accession>
    <name>A0A6A6R4L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase-like protein 105 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_557735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4L8"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000219">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 10.5 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2499406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="94" mass="10722" checksum="FF3382923030A1D6" modified="2020-06-17" version="1">MATKYGFANSLKELRFLLCQTSEHSAAARTFLTRTYPTMKKHNPHTPIMIREALGVEPKVYARYEFGKEKMITLKGLDDKAIESKVTELVKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4P0</accession>
    <name>A0A6A6R4P0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_280725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4P0"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="464" mass="49923" checksum="3FBD6EC9A09FBB24" modified="2020-06-17" version="1">MAVGVADRSTKHSRVETHSLILSDLSIQMSYDPLGLPSGIGIPETKAIPGPGFADRSRAADSGPSTTSASRSHSNKKKRTSKGKTLPEIRRSSSTPHMHNLALANSGELSPNSDKRRNKLGYHRTSVACTHCRRRKIRCLLNNDDPNGRCSNCIRLKKDCNFYPVEQTNPSDSRPQPLAKVEDGAIAPSASTPSSPRAAGSRSEQVDEYRPFTTISPNPASAGFRMQPGIDVDSNSASNPSGVPLRSHTFPYSHQMDNQWPPPGFVPPSSVPDETPSSASYWRASPSTAPSTYGSDSNMSGGQTPATMSTTSNMSYGAPHDAQGWAQPVSVQPARSVSYGHIEGVPPQFHNPHLVSQQDYRGRASPYNYPPSIDTSAGHAQGTHADTTAPLSAPLLAHTTHNYGYSPQNWSPYTLHSSGHDYSPHGRPMGGPWYAEPSHLGHVEEEAGPPMQYANQPPTFYSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4T9</accession>
    <name>A0A6A6R4T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_454515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4T9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Endoglucanase_E_like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PCW_deacetylase/CE"/>
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    </dbReference>
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        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
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    </dbReference>
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        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="45278" checksum="0655DC660293C3D8" modified="2020-06-17" version="1">MKLFSSIAILATTVSGTILQNGQVREVVFPDTSIASVAHDLSWRTYAPSAKELSYKGRWDSKHISWWSAPGLKFGFTGDKVAISFGNYTSPSVLIAYRLGGQDWLFTNVTANSTHQLISSSTTGLNLTTQAQLPQTLELRVTNWAYGVQIAGVHVSSTGELFKLKDFHKTLEIIGDSLSAGQYATYEGISSYSWGLAAGFGNVEFHITAYPGICLVDTNCWGNPRGQTYQWYHTPDTSGRALEIYGDEPEVWDFKEHPAADIVVINLGTNDNNTHNNVTNDRYLHSYIEFVAGVHRVYPHADIVLVSLWNGFNAVGNSYAQGGAFIDEIEMVYNHYKHTGFVHYFNTTGILQHNDIAPQYHPTDVGHVKVASHLMQYIHLKFGWELGATGPEVQHDTLYWNNQQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5U1</accession>
    <name>A0A6A6R5U1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_603046</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5U1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="242" mass="27855" checksum="D3DC643E69946B9E" modified="2020-06-17" version="1">MDRVDDLGVSDEPERRVSRSNTLLQESSGDEEPESTQCSMSGRFDNSWTSLKSDFRDPAALLQDSKDSEELEGTEYSTPEFIPDPLSFSPPPTVCFTPGDIRLVFGFTHRHVPQFFRQIRGVLEHALAQAAEQNVRARHRVSATVLPPSYHRRKTAMVFWSFVNLLDHHTLVHRQSTSSCCKLSLGSLNSGPIIAPHGELPPGLLWHLDDFLDRSQLHHRGKWKIKWKIKWKIKWKMKWKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R617</accession>
    <name>A0A6A6R617_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_524285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R617"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
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    </dbReference>
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        <property type="entry name" value="Arrestin_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="300"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="789" mass="86430" checksum="562C69A2EBFD82C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7J2</accession>
    <name>A0A6A6R7J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_524273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7J2"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
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        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
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        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="379" mass="41019" checksum="320DD144374FFBBC" modified="2020-06-17" version="1">MAVSFPPPPVDTIDWSNVGFKVREVNGHVESRYSVKTGKWTEPEFIQDPFLRIHGMAPGLNYGQQCYEGMKAFRSPTNEINIFRAVQNAERMQHSASYISIPGVPSDHFLKCIHLAVGLNAAFVPPHETGAAMYIRPLLFGSSAQLGLNPPEEYTFCVYVLPTGVYHGTKPVDALILEAFDRAAPEGTGSAKVGGNYAPVLKWSEKAHHDGYGITLHLDSKTRSEIDEFSTSGFIGVKKDGESYTLVVPDSKNVIKSVTADSICEIAKSFGWKIEARSIPYAELPSFSEVMAAGTAAALVPIKSITMESKGEKFVYGEGSDEPGPVCVKLLTTLKGIQQGKIDDTFGWLGKVKEPQGYSNGSVTNGDALNGPNTVGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8G6</accession>
    <name>A0A6A6R8G6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8G6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="271" mass="30359" checksum="C2D3626D343A0EAF" modified="2020-06-17" version="1">MRTIKEEKHVFPVRPSHIQMCFQARPALGKRESSYHRFTYIFGTEHLEYDSNSKPANKPVTRPKSEGFRRGSSACCVLPRSALTSPSRELLSIEKKREPSPWSPAAIPQRQSSTTVKNMASLIITGAVVVGKRMHEKHKDRKAAIIQAQQQADAQLRATESQLQLNLREAMWENELKTSMQQSEVKVRNTRVETFPRLGEKGEKDPPPAYMDVVGSRRAPEVVKGEDRFAGFAGEIGDVRRDCRASTAHERGDRHTSHHTAHGLGLSGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8X2</accession>
    <name>A0A6A6R8X2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_500092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8X2"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2501178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="582" mass="64230" checksum="3171FB4D3D011B0A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R932</accession>
    <name>A0A6A6R932_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_241076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R932"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <begin position="67"/>
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    </feature>
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        <location>
            <position position="121"/>
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        <ligand>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="307" mass="33706" checksum="BC61B825CE9FD0ED" modified="2020-06-17" version="1">METAKNAADSIAKVEEKVEHGLTLLYEKLPLWMQENHFIIRGYRPQSNSYTASARSLGYLHNETVNIYSHLLGSIGSIISGIVVYISVLPRYSLATSEDVFVFSCFFAGAAACMGMSAVFHAISNHSHAVASFGNKLDYLGIVFLIWGSFVPTLFYGFQTQPELMKRYWAMITTLSAGTAIVATHPTFRTPALRPFRAAMFIALGLSAVFPVLHGLDLNGIPAMRDLIGLDYVVAQGAFYIIGALIYACRVPERLSPGTFDIWGSSHQIFHGFVVLAAATHLVGLLKAFDHAHALRGWDEGWDVKAL</sequence>
</entry>
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    <accession>A0A6A6R9S7</accession>
    <name>A0A6A6R9S7_9PEZI</name>
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            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="981" mass="112502" checksum="C0BA530A04ED503B" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Grigoriev I."/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="219" mass="22918" checksum="EC13E7BC950D18C0" modified="2020-06-17" version="1">MTQPCGWDPGDASWCGAVDPQRAALSPKIHPNQPSISVRERSISSGSEQSSVLLPEATSCEQQEHATAAVIRRVKLHALRCSQERFPGGRAVSAACCSLSSRPAIPINGCDGSWPSPNLMSPAAPATATTSALPNTRLAAAHTTKTQHPPQTSLTKTDAGGVGVSRKGSPLPSFFSFPSTNWSALCTLPDHASPRPFFPAIAPTWPQASRGHARGLGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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            <begin position="502"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2501461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="599" mass="65943" checksum="4DA28BC787FD0DCB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAQ4</accession>
    <name>A0A6A6RAQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_427655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="53106" checksum="57E34BC56B860A15" modified="2020-06-17" version="1" fragment="single">NANHIFNAIHSSMRQWGSSLNHNGMSFFLATVPEGTQLYHGTSKEERVDGMEWLAFEPEHSLVFARGRPGPGGPGGGRPGKPPEEAQDFPPLPPLGSQHPLHESPGDGQPPRFIAGWLHTYKTNKDFRLLYVDGMSAGKTDNGTLDSQDFVLLNETEPHRYMWEYERARGMCEMAQKEWEGRIDGILRMEAGFEIILCNFSKDVDLVRATRAAGPDDRNDLGDFSGKMGHFRYMQAVTDRYPGIGGERVRLDYDHFVSAFAYPLDLFLLASGNDEEPPLPRLLNVSFDNLASIRSAVRNMILSHDAVTAARESFDWQRTADMIVARYSKPLQYLTSDPIRTNTTLFSIYLETLLRPFIDYDARPPFAEAARCSSQFVSNVPAANSSLAAGAVRAIADRICSVLSSALAAAGLVSAVSALDGLVDYLQWTSWKQCRGCGDDEVCFVPIWPFGAIEDHKRPRCLDADMLGHRMGYWGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAY0</accession>
    <name>A0A6A6RAY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_253385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAY0"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="100"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="423" mass="46107" checksum="1682647784581D68" modified="2020-06-17" version="1">MPYNTRRKSLSLPSLGIHLPNSSRSAAHRSPPASAASSEQPQPAAKKVKRSHPSASPQPSSPERTTTLRFRDERPKSSGRVAEHTPPPSPGGKSSQTKVSTEGIDDTIVVGVIEQLEKTGNRPHLLKELAAVLATSISIVESSANPSAIISSRLATYLRRPWTALSQCPLDKVLVGTHPKRVYYYLTTSEHQPIPTDSPTGPAAARIISPSLSSAASEEEEADARTRSQLSPSPELDLSSPDFEDDSTPFSNRNPLMRGGPHPPTTSNISHNRRAVSPPLERDEHEFTQTASILLQRSRSQDSESKVEIKSERSPSLHDTSMQDSIPEEVEETEESAALRNSEAAAALFGHVDHLSVHAIQPAFASSSPMLKPHLEIETTRATFKSGLSDDVKMSDDETWGWSELKSPENVELDELEDMFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB19</accession>
    <name>A0A6A6RB19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB19"/>
    <dbReference type="OrthoDB" id="3792817at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="289" mass="30768" checksum="AB9C39595311EBFE" modified="2020-06-17" version="1">MAARSRKMSGTIEQSAAGPRQTVTHLWVSNVDGPVPVRDAVRYFFLAHYLYDSQGRPVEPVTFRPNSLTFRLVRNAQDTPPFNGQNGPNNAGPVNAPPPANAFEETDTTSDQAELLNRPTSNPSTAPTPSLTYSDSTLSTQPRRHAPPSQGSAVASDIAAVENNLPMNPTLADAFGNDETLFEDTPAMQGADGEFVTGPKYIMKKPTSPRRISTRSMLSVPAVVGVEAFGVGAQGDAEGLVVEDEEGVEAWVEVLIVEVEGDAEARALRSKKQIKGAPAALRGDSGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB25</accession>
    <name>A0A6A6RB25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_577726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB25"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF4">
        <property type="entry name" value="BLR3857 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
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        </source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="249" mass="28165" checksum="0E23BC33A9FF17F6" modified="2020-06-17" version="1">MPQSDSSVLAEDHQVTDVNPIVSDAKNGSEEPFCKICLEHPQVGNQLIRMSCNEHWVCVGCATRAIQTKVDGQYEYPPRVCCGYGDIDPADHPQLFSKELVAEYNLRSIEFATFADDRRYCGNISCMAFLDPDTYCMREEYFVSLFRYATCPMEACQSMTCVECKQTLDASQLATHVGKCNPEDKPDIPLGDEMKSCPSCHYIVAIPLECFRAQCLNCHENFCWKCLKIWTGPHGCPTWQAEPDRGWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC74</accession>
    <name>A0A6A6RC74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_587684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC74"/>
    <dbReference type="OrthoDB" id="3796227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="508" mass="56135" checksum="6748DD6C192A61F6" modified="2020-06-17" version="1">MANNKLDSSKPRNERNAAEIFAVACLATPKAPVETQASKSTPSELYELAVLGYHTRMRSLNHHRRIQYGLPLPISPILPRIVVAEFIKQDKMAREKRIVPSDPGAIVNREAEELNKSAVEAPMEYAGDNETEVQWVGDGGILARVNKDWHDETTRVNMAGVQKTLRRPEYTLPVGARWLSYMKVGKTTSRHTHSSKEFVEGAVHEDCILPPGVPMSGVEILAFYPHHLHWPAVALRLINNSHTGASLSGIISWLHGQKESTVSRQIVKATVRTAGIKFTGNATWTETRHQPTPTTNISPDALVPLPRVAESGLCVPTYAQLVASLTHLPSGLHARALTACIEFWLQHKDLDLNVLHTAELYRALQPRLRSVGPMNLDAVALSQWNSSENVDGSGKRLTENLLEEYERGRGLVGERPDSSLNFHITEVLLAPLFAWQRVRVAGLNEIVKRKERTEQPAKAAYGVHTPAGPTVGKKLPAPRAKTVKRKAAEMGEGNDMKSATKQPKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCJ7</accession>
    <name>A0A6A6RCJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-galacturonic acid reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_474618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCJ7"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="413" mass="45880" checksum="9717F1E2869CC207" modified="2020-06-17" version="1">MAPLEVLMVGTGEYTTGFVGGGMSGSDKKLGVVGLTLFDLRRRGKVGKLSMVGVSGNKFPAIREHLETNIKNVYNGLDVAFEEFPKEGKRDPDSYKTAIDALPKGSAITIFTPDTTHYPIALYAIERGIHVLITKPAVKLLEHHQKLQEAAHKHNVFVYVEHHKRYDPAYADARYRAQKLGDFNYFYSYMSQPKSQLETFKAWAGVDSDISYYLNSHHIDVNESMVPDFKPVKVTASAAEGIATDLGCAAGTEDTITLLVDWVKKDDPKRRATGVYTASWTAPQKAGVHSNQYFHYMASKGEVRVNQAKRGYDVTDDEGGLLWYNPFYMKYAPDEEGNFAGQTGYGYISFEKFVDAVNGLNAGKVTLDELDKRPLPTLKNTIATGAILEAGRRSLDEKRPIEIVEEAGVWSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCR3</accession>
    <name>A0A6A6RCR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_612018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCR3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025716156" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="36"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2502341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="560" mass="59644" checksum="4CBD360D49EE9DD7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCS4</accession>
    <name>A0A6A6RCS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_612304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="289"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2503097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="887" mass="96595" checksum="A7095ED4AB2D7078" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7G9</accession>
    <name>A0A6A6Q7G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_532297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7G9"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2488255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="52728" checksum="2829AD00DCC2648B" modified="2020-06-17" version="1">MRNALNQLADTVKDPKEKQRFETEMDNFFALFRRYLNDKAKGNAIEWSRIAPPKAEQVVNYADLANSDSVEYLNKLAVVKLNGGLGTSMGCVGPKSVIEVRDGMSFLDLSVRQIEYLNRTYDVNVPFVLMNSFNTDVDTANIIKKYEGHNIDIMTFNQSKYPRILKDSLLPAPKSSDSDIANWYPPGHGDVFESLYNSGILDKLIDRGIEIIFLSNADNLGAVVDLRILQHMVDTKSEYIMELTDKTKADVKGGTIIDYEGSVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWMNLKAVKRVVENNELAMEIIPNGKSIPADKKGEADLSVLQLETAVGAAIRHFGNAHGVNVPRKRFLPVKTCSDLMLVKSDLYTLQHGQLVIDPNRFGPAPLIKLGSDFKKVSSFQSRIPSIPKIVELDHLTITGAVNLGRGVTLKGTVIIVATEGSTIDIPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q816</accession>
    <name>A0A6A6Q816_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_568333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q816"/>
    <dbReference type="OrthoDB" id="10551941at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38190" checksum="1BD9218B029E4623" modified="2020-06-17" version="1">MEAALIFDHMVRNGRPSSARSMRYRSRDQDGDSDEGEITYWMGDGDSDDSDRDDASHREEVARALRAGRQQGLQYGRNQGVQYGRQQGLMYGRQQGLQYGRRQGVQYGRHQGAQYGRQVGLQQGLQYGRQQGAHYGRQEGMQYGQQQGFQQGRRQGVQYAQGYLRRGEQMGYVRGRSEGRSEGRAEGYDDGYERGHHSGHLEGRDLWGPDVGAMVREREQQRSQQQRSQSQGPQQQRSQQQGPQQQLSRQQRGGNGDSGYVFEGYDEPDDEDDASEPSGDRRPDGPGRSQRLLQERRASVASSRRNSVHETGQRQIGGTRFGERGLLGANWDHQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8R4</accession>
    <name>A0A6A6Q8R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_623116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8R4"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
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        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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    </dbReference>
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            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="30198" checksum="1CE4AB833696C6F4" modified="2020-06-17" version="1">MSSTTSSPDYDENAASLIYEIFLAIRPQYAPFRLTANTWMNAVVPAEDNSSQTVRYYYYKAEWATEWVPLDLDPKILHQFFCLDQCDDAPVILGPIINELLGYKDSPEVFSVYVLPKLWFVTEEKPLVGKNGLRRGHTLVRIGPNVLDITGGQFGATKLRLSEVEYRRENAASQYGEGTSMSLEQAASSLPTNRTKADYWNPLFTRLRRNLDTAFKAWMTDRGLTKEKVVLDPVRRQEVVELFRKTAQMTRVEFNVEYCLGGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QAZ9_9PEZI</name>
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            <fullName evidence="3">ribonuclease H</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_422430</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
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        </reaction>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR10642">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="188" mass="21642" checksum="E85A43C9ADABBFC8" modified="2020-06-17" version="1" fragment="single">HRLVRRTNAREMLIYTDGSCYGHKDRNGISQRRGGCAFIFKPSPYNLQEKSCSFRLERLGPTGVEYPQTSNRAKLRAVIAALQFRVWRGEHFKSIVIGTDSEYVVLGITDLIETWAQTEWQTFGGTTVKNKDLWKLLLVEINKLAKEGCEVHFWLLPIHHNEEADWLAKEATTEPDVPKYLKYFGALV</sequence>
</entry>
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    <name>A0A6A6QBU6_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Gonzalez J."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2489113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="84" mass="8719" checksum="EF135FD225BC7568" modified="2020-06-17" version="1">MVQAMGAFCASTAHAGVNPGLVEGVYSGQIVSATRDTDAAASCPPLDVTAGGFVDMCKARLINAIDGCKCFPLLLDLTRFPWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBV2</accession>
    <name>A0A6A6QBV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBV2"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="202" mass="22296" checksum="31AA41597A687486" modified="2020-06-17" version="1">MAPRPFALPYNVGIDICHVPRIVRFLITPSLPSSITASQRPGRITKLLDRIYHPLEQRYYWARFGGDGVSIDIISKHIAGRWAAKEAVIKAVKPRRILLRDVVVLSHPRDSSDPSSGGVYAVVLDRPFDTKATPKPTPVTKHKPLKFFDKNKPKLQALQAEDIAKSVQGLEGEIVNLSISHDGDYACAVCIAPTMHATPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCD1</accession>
    <name>A0A6A6QCD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_622376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCD1"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="27544" checksum="5D9B837B39C09C71" modified="2020-06-17" version="1">MVDTMQSSNPNPLKRPHSPHHPPHSRRLRTRLSPATSSAASAASVSQDSAVFSTDRASSTEQTADSEPASANSDNSISSPSSSSSSSSEESEISDSSSGDDSSDADAESEGEEEEEEEEEVIGDEEGEFEDIENADGVVEIGRRKRKPLIKATSARKTGDLRARLKMFLPMLAAANEELEVERREGRLGGRMLDLGEGGVGEGEYIEMDLGLGVLEERDPDAEEESGSDEEDGMDILGKLMGQERAKEGGGIQVVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD49</accession>
    <name>A0A6A6QD49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_622920</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD49"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2489397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="47913" checksum="18B74D34BE885E6D" modified="2020-06-17" version="1">MGTHSSISPSPDDLESLEGADNSVDGPLEGRRYQSCFIDGIEDLEDYCEGGFHPVFLGDELEGRYRVVHKLGAGGLATVWLCRDREMEKYVAVKIIAADQSREDCADLKMTKLEGCDGLGLPQHQFWVDGPNGRHLCLVLPVFGPRVDQAWDLFESPERSLRNIALHATKGLHALHSNGLGHGDFRPANILLQISSLDHLNEEELIHALGKPESFEVYTKSGEEPEPAAPKYVVAPIAWDRNVDRKYFKDQIAVVDFGESFETSNPPKELGTPTAYCAPELLIGSIVSQASDLWALACTLSEIRTTRRLFRDWEGDGEDPKWQMVVLLGKFPEPWWSSWETRKNYFDDNGDPYMTESGHMSVSGARTIEEYVEEGVTHDLNGVITKSHTIPRDEGRVLADLLGQMLKYDPRERISTATVLEHPWFKM</sequence>
</entry>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
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                <person name="Goodwin S."/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2490024.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22462" checksum="545FA390E91AE65F" modified="2020-06-17" version="1">MAKADNITQSTTTTTIENSLSAATANMTIATPTSNGHTSTPSKLDKPASTTAPTAPPTSALTQAALDFLKDFSTLSPAIITSHCTPDFTHSISPASLALPSRNLEEFKTHSARVYSLFSTWEIVPDTVFEDVGKSTVVAHAKMGGKVKGRALGDVDFWKNEAVFWIEMGEVEGRWMVKAVREFVDSKLGEELRRRLTGTAKERTLEE</sequence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01466">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="56"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEQ5</accession>
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    <protein>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
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    <sequence length="1031" mass="114092" checksum="B602FB04A07E3775" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGP8</accession>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        </source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A6A6QHA4</accession>
    <name>A0A6A6QHA4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_542540</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bills G."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="17000" checksum="52D9CCCF648B3155" modified="2020-06-17" version="1">MAMLAVAISSVFASPIEKAEEFAHTMSKRVDLAPRDKRVDLPPKDKRIHPPTEDKRSDLRIKHTDFHWRFYDTGNCDHSVQPPDSFPSGGSPPGDGSIGVCYSAPEGVQWNRVEIDTFFADGGALGLQGPCNTGCGGGASVKQQGTNCYLPTSGYVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHB5</accession>
    <name>A0A6A6QHB5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_515789</name>
    </gene>
    <organism evidence="9 10">
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        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHB5"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="161"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="401"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2491426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60676" checksum="2D560CC5D1E97C6C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHI6</accession>
    <name>A0A6A6QHI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_621758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHI6"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="246" mass="28754" checksum="A709C4CF490AC7ED" modified="2020-06-17" version="1">MTGGATMRKNTDRPSFRTMKQTVVTILVGKTEKAYIIHLDLLIHYSEYFRAAFTGSFKEAEDKKISLSDVKKSTFDRFVDWLYYREISPTEEDKDPETGRLQYRGIIELYILGDKYQIPKLRKYVIDHIFQSLTTSLELLPSPGAIARAYEFLPETSPMRKFMLDIFARRFTPYYITRAKKMNKNPSCLQNEFLIEALIKIADNTKAINQNQRSTLKLKLCDYHEHADDKERKQCEQSHGVADIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHV1</accession>
    <name>A0A6A6QHV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptide hydrolase</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_565379</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHV1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000054">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000030">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF57">
        <property type="entry name" value="PEPTIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025709957" description="Peptide hydrolase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="14">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2491679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="516" mass="53900" checksum="0A3DAE0A3C139EED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHY9</accession>
    <name>A0A6A6QHY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_129633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHY9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="13392" checksum="E478B8E40A002A83" modified="2020-06-17" version="1">MVPERRRVSSRGSPYASGAPKMPPTGEAGSRALAGPQGVQEQHAGRRQRPASWPAVHRYYNVVVVAAFRRDGRGREEPSLTQRVKLYATSPTAPPCSRGLPALRSDAVGQGARCRSCSPQSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI38</accession>
    <name>A0A6A6QI38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_621376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI38"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="233"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="493" mass="56193" checksum="8C5657A72911962C" modified="2020-06-17" version="1">MATPVGEQASKSTLPSRFRSSSLDDEQRVTRRQQLNSKPQRDLVCQRCWDNIFTSNHFAKVCRGDKDSDGEYLRYEYDIPYGHLQESEAVCNWCRVIHLCISRYLRESEPSLELSSLSLSYNVRIRFTTYGYKGDDNIYLELNASGESCYGIQTWAHPDDVAFDFVKAHPYKHEVNTEEGFNEARAWIRDCAFHEHCLEERDMELPTRVIEVSPEDHPGQPRLLLAGGRTGRYAVLSYCWGRDPTGVPTLLANLESRLNSINVDDLSRSIQDAIFWARQLGLQYLWTDALCIIQDSEGDKAHESANMGRIYQQAHVTIVAASASAAKDGFLGDRLAPESFSVPFPFPCPNHEMGTLFLVLEARYFPQAEPVNQRGWTLQEWYLSPRRLVNGSRELVYDYQTVALTWGSTQHPRYLSLPSRYLSPPEENVPLTSGRTQEGLDDWIMAVKEFSGRKLSHSDDRVIAIGSIAELFSSWLGDYACGLWKVELATQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI65</accession>
    <name>A0A6A6QI65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_551840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI65"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="251" mass="28028" checksum="85BF09D65F5B8781" modified="2020-06-17" version="1">MKIIPTPFFQTGLSDQYTQVASEMALVHNIISRAFNGIYLQAPHVHPSEYFAFLSYCKASFDGLAAHHMGEETHAFPAIEEATGQKGLMGVNVAQHEAFHDGLHKWGAYISTLLAGDVAAFDAKTMLAIMDTFLEPLTTHLNDEIPTLLALREYGDSLDLKGIVEKEVEMVMGSLSKTTQLPLFLLNHDVTFEGGIHDFPPIPPPVRWALMRILPLVHPSWWKFASCDSSGMPRELYRRGVKPEECGQYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIZ7</accession>
    <name>A0A6A6QIZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Asp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_467674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIZ7"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025363074" evidence="9">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="85"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2492385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="394" mass="40880" checksum="6E0D1025B35F0F82" modified="2020-06-17" version="1">MPSFASLTALVAAVGLVAASPVSLEKRKAFTVEQVEKGKFIRNGAASVASTYLKYGKAVPANIAAAAAAQGSVAASPSDEYDSSYLCPVDVGGTTMELDFDTGSADLWVFSSLQPSSQTAGHAVYQASSSKVKSGYTWKISYGDGSGAAGKVYADKVVVGGVTATSQAVEAATSISTQFQQDTNNDGLLGLSFSSINTVKPKAQTTFFDTVKSTLAKPLFGVDLKYHAAGTYDFGFIDTSKFSGAVTYVDVDSSQGFWGFTASGYIVGNGTQSSTSIDAIADTGTTLLYIPLAAVKAYYKEVSGAKLDSTQGGYTFPCSATLPDWTAIIGGTKHTIPGKYINYAPISDGSSTCFGGIQDDSDIGQSIFGDIFLKSQYVVFNGASTPKLGFAQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJF5</accession>
    <name>A0A6A6QJF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_542063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJF5"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="408"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="517" mass="58170" checksum="CB05ADDA452B4BAC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJI7</accession>
    <name>A0A6A6QJI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_574315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJI7"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <source>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="EMBL" id="KAF2492023.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QLI2_9PEZI</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
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    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="74"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="312" mass="34179" checksum="FD9F658E6AE07220" modified="2020-06-17" version="1">MTTTQAKSHPLPTYLLIKVLATILRTIYALFLASPSPKPTSTLFIPSRNSKRTIKVHVYAPPSPKPTKAPHPVLLNFHGSGFVVDMHGSDAPFCRQIASATGLTVLDCDYRKAPEHPFPAALEDVEDAMRYVLSRPEEYDATQTHLSGFSAGANLALAVCGVPLRDLGTGFIRERVRKVVAFYPPLDLATSPATKRAPDGSAGTLPVPVAKLFNTCYITPGQEATDPRISCKNMAPEAFAKEAFIVTCGKDDLAFEAEELASRMAEREGCRVEWKRVEGVDHAWDKSCKKGSEEDEKRAEAYEWAVEFLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLL2</accession>
    <name>A0A6A6QLL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_563404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="297"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="617" mass="68463" checksum="B712498CCCDFB7DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM68</accession>
    <name>A0A6A6QM68_9PEZI</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5215300at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
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    </dbReference>
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            <end position="916"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1139" mass="131518" checksum="D53FCD4B247C38D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNY1</accession>
    <name>A0A6A6QNY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BU16DRAFT_528030</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2493826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="434" mass="47357" checksum="399E178AF49E1CB9" modified="2020-06-17" version="1">MDDDAPTTQLPIEQTIRQTLDRRRAQSTLRNLLVSPTGSVDFSSNDFLSLSTSPALRTAYLQELSNTTCKLGSGGSRLLDGNSAYAEDLEKSIAAFHRAPSGLLFNSGFDANAGFFSCMPQPGDVIVHDEFIHASVHEGMRLSRAAKCLPFLHNSVEDLKRVLEECEENDGLVRDGRRSVFVAVEAIYSMDGDLLPLKAIVDVVEQALPRKNGYIVVDEAHSTGVVGPFGRGLVCELGLEDKVFARLHTFGKALSSNGAIVLCSPVVRHYLLNYARPLIYTTFMSYPSLAGIRASYSLLQRGDTEPLALHLKWLIQATFDMLQDLVAKHGFNNGPAALLRVPAECPQSPIFAVITPHPRSLAKYCQDAGFVVRAVVPPTVPHGSSRIRVCLHSGNTYDEVRKLVDRIDDWVGVQTEGGDFAGDALPPALEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPC3</accession>
    <name>A0A6A6QPC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_421668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="80" mass="9379" checksum="9743E2671319FFAA" modified="2020-06-17" version="1" fragment="single">LKPQHFLDWANTQHTEHPDVTIAQHPLCVICLEEIEDAANIRGLGCLHPFHQECLDDWYSRWNEYCPLCHRPIIQSTKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPL4</accession>
    <name>A0A6A6QPL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfite transporter Ssu2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_40727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000005">
        <property type="entry name" value="Sulfite efflux pump SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF2">
        <property type="entry name" value="C4-DICARBOXYLATE TRANSPORTER_MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="446" mass="49293" checksum="2EF8D43BFAFDB501" modified="2020-06-17" version="1">MQDSDHDLTRLASGKPALASTPSLVRQRSSHRHPHATTSDPSGEQDVITEPPPDQVTKYDVGWRRVVRNFSPSWFSVTMGTGIVSLLFITIPFQSDWLYWMSVVFFALNTLLFALAFGISILRYTLYPAIWTVMIHDSTNSLFLGTLPMGFATLVESWIFLCIPYWGPWAVTFAWVCWMIDCIVAGAVTVSLTFLLISQSHQQALDRITAAQLLPIAATIVAAGAGAEIAEVLPNPDHALGTLITSYVMWGMATPLAMTVLVIYYQRLALHKLPPREIVVSSFLPLGPLGMGGYTIMYLGKVSREVFPQVHFFHDLAVAGDVVYILGVFLALIMWGFGLIWFAFALASIYKSRPFPFNMGWWGFTFPLGVYAVSTIELGNQMPSQFFKVLGTIFSVAVILLWIVVAIGTARGAWDGKLFHAPCLANLKKDENATITPPDNEKATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ03</accession>
    <name>A0A6A6QQ03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_528252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ03"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="508" mass="56569" checksum="ABDF6694E688B8BF" modified="2020-06-17" version="1">MQSALRASRPVVTRALAVMNARAVATQAQKRAGDISDAFVSLSGQQFTPLAPEYAHLKGRLIKGHEEALRRSWERLLRDLRQEIPSILELGSKVIPEIDFKDIGNASETFKQEHRKRGVAVIRGVVPEKEALQWKEDLRDYIARNPHTKAFPPEKPQVFELYWSPTQLRARAHPNLLETHRFLMSFWKSKDPAAAISTSSPTSYADRLRMRLPGDAKFALGPHVDGGSVERWDEQGYGRGSVYDSVWSGEWEKFDPWESSCRLPVVSDLHSGVGSCSMFRMYQGWLSMSTCGPFEGTLLVNPLLAKATAYYLLRPFFSPRKGVELGAQTATENVTASSEFLASDNWVLDPTPSSWLQGATPGHGQELSPLLHPHLDLNHTMVHMPTVRPGDYVAWHCDTIHAVDKIHAGTSDSSVLYIPACPLTEENAKYLARQRDTFVKGEPSPDFGGGEGESKNVGRIWPEHMETLVGEEGCRAMGLKEWDSSAEGLSAGEREVMDRANKALGFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ72</accession>
    <name>A0A6A6QQ72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase/oxidase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_528079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ72"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="208"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="651" mass="70642" checksum="6C7CF32C9E24997D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQF3</accession>
    <name>A0A6A6QQF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_590802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQF3"/>
    <dbReference type="OrthoDB" id="3792649at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43816" checksum="6D09FABEDED37653" modified="2020-06-17" version="1">MATTSTSLVGTIVSESSDHNILGKLMRLNILEHTRQEREKHHAEQAMIAATRNATQSCFYQLPAELILTVADVLTTPSLISLRGTCLKLREIVKQPPMIQADERHEIRHILRRDAYTSYCNSTNENRIGMRKKGCSFCKTTHQLHMFTAAELRNPPSQRLCRGSSGSIKLCKHMNLGLEDLQKLKFNQSFDCRHLDHGFDNDHPRICCGTGHISRTSTWALTSDYNVRICTITRLAPLTRGHLERAFVRMKRLLYFCPHMPVTDCMFKLYEQVDCRFMNGFSHSTPNGLGCRHCGDSVSCEAKGCSTRCVLFRWRNHLTGLDEITLKVTRGFGRGEATDLEWLAQLDPSSSVLTADVSLTRKVLGALGMLALRSRSASSDPWIASRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRM1</accession>
    <name>A0A6A6QRM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Checkpoint protein kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_509603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRM1"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="877"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="755"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="342" mass="38529" checksum="F3D7DECD2B17E01F" modified="2020-06-17" version="1">MSLPAPAASDESNERRRSLGKYVKRMSSVFKRGGSSRPSAPASTSTATPATAPATTAAPETTTPAAPASASAPVATYQYNRSAVQQERARALFAKYGLTLESHEWITPAASNVQRVEKPIRMRVHRTCHRCETTFGQERVCAKCQHKRCKKCPRYPKKKVIGDNKDDLVTEQRPKKKMLLTIKSKTGGDLVYQPTKQRVRRTCHKCESFFNPPTATVCEKCEHVRCTRCPRDPAKLKKWPDGYPGDAPAEDSETELDNERPRRMYRRPRQKVRWECEECQTLFVDGASKCEGCGHDRCDTCQRKPPKKNRVQKEFDPEIVKSVEEKLARFKVGETPTSVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTN8</accession>
    <name>A0A6A6QTN8_9PEZI</name>
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            <fullName evidence="3">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_540758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTN8"/>
    <dbReference type="OrthoDB" id="4341326at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39747" checksum="AEEEACC98E2BE789" modified="2020-06-17" version="1">MANFVSHVAPVALENARSIIPNDYEPDLFNDMGFVLRAKADSGEDIHLWMFMYRQRGEEVIINNEVCQTLMVSAAYTPAEKESMHDTPFINKGQNIDDYHKLGSLTFQDTPTTNTWTLAGRVFESRANQWTVSGSHAGVSVQLEWTQRGDALYNGGPFAELHSGKGHSAFIVHAHVTGTVTAGGKTMTVSAGNGHGIHERICMAGHVPARLQYMMERGMNWLNGYGAEVSWYIKTASRGRSATMMLNVDGETLAVVGGQKANIEEIDFWLDPKTNQMNPRKWRVWAVVKGKGRLEVIVTAYGRAYYTWVRQGGVVLVNQFVADAVCTWTRVDGSKIEEKQMAMNEYMRTLYVQPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTQ9</accession>
    <name>A0A6A6QTQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_526997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTQ9"/>
    <dbReference type="OrthoDB" id="10462140at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="24897" checksum="B84EED2460C5C1F8" modified="2020-06-17" version="1">MLSSDDDEPTFNRGPPFFGWNGFSAQREPSLAGAQQAFEEYNTHWDQLDINDAAIRYPTPSGNGGDLLDVGSRYMQQIKSSNRYGWAPKLPNSNLPIHPHQVVRYNIFGFFIAAFGIRVRYTVLEGLENGSSPQWKPDFRQADQEKLKMLRDHLRRKEQKRWHPDQMNRRKNGVVGLGDEEVFLKGGISMTGRELREAVCLAITELRQVYVETALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTY6</accession>
    <name>A0A6A6QTY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTY6"/>
    <dbReference type="OrthoDB" id="3792622at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025617812" evidence="2">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="202" mass="21320" checksum="FA5552BA5D930204" modified="2020-06-17" version="1">MRFRYTVLVATSPLLFNVQGLPTPEAVSKRDLVAPVDSGIIDLTPPDTTMTWGKNRREAGANPDLVVPVNGGVIGLTPPDTTITWGKDKRDPDSVIPLDGGIVGLTPPDTTVTWGDDTVTSTTTIGKEKRGPDLVVPIDGGIVGLTPPDTTVTWGDDTTGDVSSTTVVENEKRDPQDPALSTPSSTITWAKGKRDLPILALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUC3</accession>
    <name>A0A6A6QUC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_363396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUC3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="175" mass="20255" checksum="AC64F1AAD4321DCF" modified="2020-06-17" version="1">MKVGIRSITLINCLFVEWELRSLFHHVLPSQNMTEIYLCEYLTCQDYCARLMGPPERLPKQHKQYYRPHEKTTKATSEAIKQPQTRPRVISILFRLERFSDCKRNRQSVPSVSTATSRQATKSRPHQPTSSSTTQSRLSDTKQQTQTDLAPQTLSISESRRAIYLFLPEPQEANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUG7</accession>
    <name>A0A6A6QUG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_388281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUG7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="17710" checksum="97814C159B95FC8A" modified="2020-06-17" version="1">MRAIGNVDKEAPVQIDPHHRGQLTLETHLKYLASRTILEARDRELCWPLSFVFSSHCAPPFGHHSPVCLGLTTAHWLLRSALTCNSCIAAYSTLDFSPYDKPSALQGISCKRARPSALRTSLTHLRQTRPTSQKMILLTKTILHKPRLEPLRRILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVE4</accession>
    <name>A0A6A6QVE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_459859</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVE4"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2496122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="369" mass="38971" checksum="B583D316294D2117" modified="2020-06-17" version="1">MNAIDGTDRHIKSTDGPPPSLLTIILDTNPFAWAHLSSILPLSSVVANLLVFINAHLASGNANEVAVIASHNKRTAWLYPTPAPVSAHNTNGDSSSRNGAATHTQNANKYQPFAEVETNLLFNLDNLLKTTTSDDLSTTTTQIAGALSTALSYISKSTIRHSPVDPTLLESHALVIDDGNLTSQRVNLVSRILVLSVSGDLASQYIPVMNAIFAAQRQRIPIDILKLAGDTVLLQQACDATGGIYMAPESPQGLLQYLMMAFLPDATARKWLVLPSAGSVDFRAACFCHRNVVDIGFVCSVCLSIFCSPNLPDSTCLTCSSVLSLGGAITAAPALIPRKKKKRKRVAGDGSTPGGSATPLPGNGTPVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVH8</accession>
    <name>A0A6A6QVH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_617626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVH8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="34737" checksum="422CE95CE10B4591" modified="2020-06-17" version="1">MPSTSNNFVLPRPGFAPSPPVPPIPAPSESAFTTTFGALLPPAQYLHLHQGNAAYYPLPPSTPSPNPPRILLIHGVQTPALGLLPLVRALRASFPTAHLALLDLWGHGLSDTPVLPHTPALFHSLLDAVFDALAWPTAHLIGYSFGGALAVGYAVSRPSRVQSFTLVAPAGLIRSAALTDEERGHLRGGGDEAAARRWVLEFLGGYEAPPGDWRERVARGEVVAEAVRAWQMREHGGHGASVVAVVRDAGPFDSDAEFLKAVQTGIPSLVVLGELDEVCAERDIKELGFGNVVVVPQVGHGVVRERVPEVAGFISDFWTKINLTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVN5</accession>
    <name>A0A6A6QVN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_616704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVN5"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
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            <end position="355"/>
        </location>
    </feature>
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        <location>
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            <end position="376"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="437"/>
        </location>
    </feature>
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        <location>
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            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="800" mass="87939" checksum="86AA884646FAEB71" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVY0</accession>
    <name>A0A6A6QVY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_485451</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="409" mass="44505" checksum="A0CCED76AE2CFC22" modified="2020-06-17" version="1">MPSIRCYVFSALAAIVSLASAGQTCDAFGIDYVDGGSYFINTLSQDDFTFVTEFEGCNDDIANTMLVPPDDAPDNDEIICSDIDTTDVDDTPEMATCPIKKSEMVSGGWIILVMGNNNGGDPFAYERDITLDCGPQVTATVTPTVTYNITVTPTSTSTIWSTVTNTTTFGPTATFTVPSKTAHYTKTVTPAPVYTTQTWTVTRHRLTWTKTQTIKTTTATASCTVPPRPQWPDKTCTYSPTKLHPKALETGKPNKKQTSGWHWRGAARAVNVEEARRRFDAAQKKRDMKERAAVQVEERAPDAPTVYVTYSVAVNVTSTLTAAPTTTTETDLTTTVTSTTLPPVTVFSGIYTSTITLPTKTKTKKTIAYTTLYTTKTIHATWTLTKTVTPTAVVSSCKTRGGHWGPGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVZ9"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
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            <end position="41"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="137" mass="14716" checksum="379BEDB21DA49D40" modified="2020-06-17" version="1">MRDKGTVRSPADVAAWQRGRIAIAERLPKTMGRKEPREKHPTCSSWPLLCGSAARKSGRPISRAEGGGLVTSRGRHSGLRTAAVVEQRGRAWASRVASALEACLAVLALSAAHCSRRALTERRASRGVRGEAPQGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QW53_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW53"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="16624" checksum="70916FE29B5D30BD" modified="2020-06-17" version="1">MSIHCAPSSPSKRSGCYFADLVVSLPYNLPLEPLQNPEMSPVPLVDRTTEITFYNHLASPRTSSFLSSAAAFSPLYRQEAFKCVDAEGRVEAWTFAANVWVPIPDPDLDALVLGEWAGIVTLVAPAGKDETWEIKLLGWDEVVGGGGGVWGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWU4</accession>
    <name>A0A6A6QWU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_538032</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWU4"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="450" mass="50966" checksum="CBD0518DA6E0BA11" modified="2020-06-17" version="1">MLNSDHESAVSMELPQHDQPASSGCENGATFDDLPPELLLRILESIPRAETGTLHSLSSVSHRLHQLVEPYLYQTVQHDVCVHKPLCYLIRTLIERPELALLVRDIEILAWREYDSDKWSINRMDPKEVRPIRSAMATKASEFRFHKQSKYWEIALSLGVDHAAVALLLFITPNVENANLHHFICSNDFWFVQLLTAAYKDPEPDFKFQGLPRLKELTLQAGSQEGARGLAPFFLFPALSKLEVHKASDRYIQQDDWQPFTSNIDTLILNGCNLCVEITEAIIHSCKALKTFEWYTKPGKTARHLVTDRRFQTVSSALLQHSASLEKLVIPPLPAFKRIPDKYPVLRDLRLFPQLKILRVALDTILGRFGSDSDPELSLANALPPNLEELELMFVWGYCDDAGIAPSSLAEANRKLLYTLSAFLGVSVTVEQWPSRTEIPLPDEDDFGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYN7</accession>
    <name>A0A6A6QYN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R023</accession>
    <name>A0A6A6R023_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_559073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2497320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1521" mass="172729" checksum="7BE1D482C8A83D3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0H9</accession>
    <name>A0A6A6R0H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="5" type="ORF">BU16DRAFT_525578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="26936" checksum="8185524BA9A63566" modified="2020-06-17" version="1">MNVSGLYFVAEQPSSSSASGSSAFQNIVSAIQLNFIATPLPNWHLAHHLSLSTPATSGDTNPPAYHHALSLTYHPGKTFLHIHPQPVPGVPTKPGPDNVVVAIPATQAESFNNLLATKLSALWTPKHSLNIRDGHAYRIGEMVIRVGEVRAAKGVGGNPPALHGVVVCIESRVGDANTSDDDYAPAVPSKADVSEGVMAVHEMIRGLWNDLEVPVGRKEGVKMALGQYEGLGEEHAAEAEVRMWCQILRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0N1</accession>
    <name>A0A6A6R0N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_289989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0N1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="480" mass="52556" checksum="B2A49E40926CA348" modified="2020-06-17" version="1">MCRATLFKHPRGVVAPPGFWDRPQSLSEIDRYIALVANDVRMRRRGMIPAQNWSSDAPPRDLAAFPNLHLHLHHYNHAHDALAAQSEVDVPLPRPSVRFPSQDDDQQASTARDGESRGPAHSLRFRIRQVFGGNDDIRSNEPRALPSRWDAHPEQQPGSVGNPISLDEDTANQGTGSQRHNTTTDHREGEIRRFFEVPIRRRPDEGPDRGLPRQGPHPRDVIVIGSPPRPSSAAAYQNQPLHMTQAERQAMIDAIALDRLHRSFPSGSDTTYEGESSDDSSPAQPAVPLGSRDYSHWRGHSSGSGQPRHEDPSTSGVLPPPGWRRPPGWITPPPGWRAPPGWRPRTTAVTSLHPSQTLRPAADQPAANLTPATEAPAAPIQAQPLPANDLPTAPRGGAPRMIATSSSAVVNEEPVSHRTRNRVHNAAEIGAPVAPKAPTARKQPKRARNSSPPPAMAMRSTRRTAQPKSEASRPAKRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0S5</accession>
    <name>A0A6A6R0S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_559191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0S5"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
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    </dbReference>
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</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="1734" mass="190843" checksum="F80231CDE2B0FD19" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R294</accession>
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                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_536230</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2498170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2N5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="125" mass="14870" checksum="C6F2DC3C950EB556" modified="2020-06-17" version="1">MAKELENSKLSRIKGLNIKKLGLYFFKSLPSSICPAKKRPRYIKEEKEKKKKELVEIVKVEREKKEKEKKKKELVEKELVEKALVEKALVEIVKVEKERKKKEIKKKEIKERELVDIVIVEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Q0</accession>
    <name>A0A6A6R2Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_524650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="628"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="981"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="217"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1168"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2498554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1195" mass="133864" checksum="8EA945E826B2A137" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3J7</accession>
    <name>A0A6A6R3J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_570955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
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    </reference>
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        <cofactor evidence="1 5">
            <name>heme</name>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="512" mass="58682" checksum="AA826DFF5A456D3E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3L5</accession>
    <name>A0A6A6R3L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_524484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3L5"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000007">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="604"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="969" mass="106780" checksum="3129E3821CCFA7F6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4G2</accession>
    <name>A0A6A6R4G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_523849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="239" mass="26228" checksum="94647998EA73F156" modified="2020-06-17" version="1">MQRAPPSLPPSLLTHSFTIHPTKPLPHIPANLNTNTPRYLTTMSAKITKTSDLPPSEAKWISFQKIDWVDQAGKARVWEVASRKTRGSSGIDAVAIAAILRSPTAPPSTIIILQFRPPAAGICVELPAGLIDAKETPEQAAVRELREETGYEGKVVGMSPTIVSDPGMTTANMQFATVEVDLKEGEQPEQQLDEGEFIERVVVPIHELYARLLKYSEEGKTVDARLWHWAAGIEFAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4G5</accession>
    <name>A0A6A6R4G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_503902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <location>
            <begin position="725"/>
            <end position="923"/>
        </location>
    </feature>
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        <location>
            <begin position="1267"/>
            <end position="1477"/>
        </location>
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        </location>
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        </location>
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            <begin position="51"/>
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        </location>
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            <begin position="113"/>
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        </location>
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        </location>
    </feature>
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            <begin position="1387"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1536" mass="169820" checksum="C28592F2583E902D" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5D8</accession>
    <name>A0A6A6R5D8_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2499140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A6A6R5J1</accession>
    <name>A0A6A6R5J1_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_524804</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
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        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="157"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="549" mass="60296" checksum="63AA0928CDA60A0F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R663</accession>
    <name>A0A6A6R663_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_557730</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R663"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2500888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="101877" checksum="24A4E08C7CEF913D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R897</accession>
    <name>A0A6A6R897_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_253389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
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        <property type="entry name" value="TBP_CS"/>
    </dbReference>
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        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="245" mass="27002" checksum="3837FE49CEB1240D" modified="2020-06-17" version="1">MDSLTTHPQTAVQAKAFVAPTSMSYPGGVPQELTPPSSEKNIAQDANAVNGVQTPAPTPDTQNSASGIIPTLQNIVATVNLSARLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALVFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIRFPIRLEGLANRHHNFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8E6</accession>
    <name>A0A6A6R8E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_578718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8E6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="192" mass="21867" checksum="F095B38FB6DA4C72" modified="2020-06-17" version="1">MSHFEPVSRSLHFFFRFFQAVPQQALSTPLPTRPAPHTSPDLPIPTRMADDSSVFLQRARAYRHFSELLTLIELHSLDITPADHFESVTYNEFHITLGELKALKLPQLTKAFLVGLTHFQANMRYSSPTIDDPIGGESWGDMLAPYLEDPGAFQRDVRPRARIFELQLEQVNVLRGEFVYRILDLGLVMGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9K5</accession>
    <name>A0A6A6R9K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_522306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9K5"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="86"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="193" mass="20460" checksum="961BAD72F67E9D45" modified="2020-06-17" version="1">MSKRVDRSAGRGGSRGSSVNLSDTPFDRANRFFELASVEGYDGHDASLPQHLSLLEATFTPTPAHPHLARSKFLLTVPSTLCNMSGSLHGGAVALIFDICTSVTISVCAKEGFWDSGHVSRTLNCTYLRPAAKGMKVVVESEVVHLGRRMGVVTGVIRGATAEEGGDEVGGSAGKVFYTCEHGKACLESTSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9M6</accession>
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        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_248289</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500500.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="630" mass="66533" checksum="2AACC6B322C6154D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9R7</accession>
    <name>A0A6A6R9R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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            <end position="327"/>
        </location>
    </feature>
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            <begin position="313"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="37279" checksum="2B83D87796E37069" modified="2020-06-17" version="1">MFQLGNSPVLCKRSAGECPAAAPHGRLDYACQAPIALPLQEVTPSHFTKYTRHYSPTVPHIHSTIPQLSMVTDGAQSSLEELVVAITSYYEFLISFYLPASSLKFAPMGGWPDIHPSFFDPPKSDTIMEILRNIPYIDARERHDNPFQLYEGCEGMDYTGHEFLGNGPHDAERDPLTDDAEDIGVDISAHTIVLAAAPTRDGWHFILQTEETDWMIELWDFQCDICERYPVKAFFEKLKERFRTLEVYPIDPEQVVMANGCPAAANAEYTTMFHAFGWPTAEYRKKECMREIKKAWNENMGFSDTDDENENEAVEKEVREGKEEMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA99</accession>
    <name>A0A6A6RA99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="212" mass="22060" checksum="42D3DF2B99196BAB" modified="2020-06-17" version="1">MTSLTATFNPADVSTPGHYGPSQTALLLLDFHSLFVQKPAGAVGAPALEVAANMRTWAKSQGIQVIHCLIDINAKPFPTCKDPERLAGLTAAMKSGGGEEAAELLEGTGDEATFLRVPGHVSALKSPGLGDYLEKKGIKSLILTGLSTSGCVMRTAITASDAEYVVTAISDGCADPFQDVHDIMVGKVLTSRGYVTTAAEFQEGFAKAFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAS5</accession>
    <name>A0A6A6RAS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane fusion mating protein FIG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_502909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    </reference>
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            <begin position="237"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="270" mass="28999" checksum="EAEF2C58C973F7C6" modified="2020-06-17" version="1">MANLKFAVSMQRLIPFLGYHHILMILIAIAIILLSLLLAGCSSTSPLIPGIFLISMYYQHYTPSYDTSQVDPGVTAAIANIVGQAQLGVRVGYFGICVSPDGGDFLCSNNATALAEQVSVDQDPLNLIWVASTFKDSIIFPYLLIVAIILAFITFILLATFPGWHEERDLQTGSDVDVKPFPSRPVSQVALALIFIASIFVLVSVLWQHTASVAAATIAQDLGNGSVKSGVGTSAMVLGWFGFVLLIIVTIGLLVMILSIIVLDRLTDND</sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="612" mass="68723" checksum="9BAE465D334A5269" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="291" mass="32423" checksum="0654624F60B94660" modified="2020-06-17" version="1">MSQPPSPPEPSPYTTLPLTGPHPTGVGHALITLVEPHPGHERAYNRWYEDDHMISGALQLPWLFSGRRWVATHALQTLRLRLPSPLLIDPPSAGCYLSTYWITPGRLAEHKEWSYAVYARLVAEHRVYEHRDHVFTSFQDKAGTVYASPDVPRDVFTLLDPAPGLVLEILDAEDEAGDASALRAWLLETHLPARVAIAASPVASAMVFGTRPAEAMPAEVLARVGEGAGAASEPRRVTVLWFLRREPREVWGWFEGEEERVRAGRLGRVRFCAPFVPARMGTNEFDDQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBY7"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2500947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="34485" checksum="D672B243B205D96C" modified="2020-06-17" version="1">MGEIKKHTITEPWLKLSCGLGEAPFWEEQTHTLRFVDIIKQELHTVDLAKGPASHKIAASLDISIGVTGDIEGHDKGFIFGGKHGYGIFDRETASYKYIKKVWSEEELSDGKDKRMRANDGAIDSRGRFWVGFMDDPLIKDPVDEGVLFRLDPDRSLHRVLEGVTIPNGTTWSADDKHMYFTDSPTRNIYVFDFDAETGAISNRRVFFRWAENLDAEPDGHCIDEEGYMWSAFHGSGKVLRISPEGKVVAEITCPTPNVTCPAFVGEDLVITSAGGDEKPETMAGCVFKIHVGVTGLKRFRWKSGIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE64</accession>
    <name>A0A6A6RE64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_521598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE64"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000268">
        <property type="entry name" value="Ubiquitin-like modifier HUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="27651" checksum="8417A698AD3910D7" modified="2020-06-17" version="1">MSPSTPPATSTVAPIAKAKSRSRSPPPPRKSTSPPPRRRSRSPPRRPRNNNNASGFRWKQARRDDDDTRSDDRQLNRGYRQERNERDGRDGGRRDDRGGDRGGDRDRERFGGRRDERDRDGNRDRNVHSDRRRDDRPHRERDPERPSKSKEKKEKPAPVAVGGGEPMIIVTVNDRLGTKAQIPCLASDPVRVFKAMVAARIGRPAHEIMLKRQGERPFKDQLTLEDYGVSNGVQLDLELDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE93</accession>
    <name>A0A6A6RE93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_450553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE93"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="5">
        <location>
            <begin position="343"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="463"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57446" checksum="52A63B6BBF5205E6" modified="2020-06-17" version="1">MANIKRQQQDEEFEEYSAFAQRPLALEDGKGWQSEELEPAEQQTTVTVVQETATVEPDNAADPDDWNSVMLDDFDNNSTSSDVEGPVERILSKRTRKSGLSYLVVYDGRLTDDARWLPANYLTTEHDITLLWDFETKLQAKEELQRQALESSDSDFDSSDDEDDEDDFQDEKDLIARRLERMTDEQIARRLAKQEELGLGSEEVLLFDDDSAMDEDMEKEEEGYFTKSAFASSSRSRKRGGRARGAFPSASLMADVLEQDPYGGFDVMDTERPSLKKKSKGRRGQFPAEISDSDLEAQMRSTWEADRRKKAEYKKDREELRAQGLLGKKNKDKADLATKYSEGFTMVEILEELREFLISDHQSRALPPMEAHERAHIHRFAKKMELTTKSVGAGKDRFINLSKNTRTRPYREIEFNSVMYKFRFLNNYPKAPKGAARPRNVAKPTFTYRDGDVVGASAPEIGEGNKGHALLQKMGWTKGMALGALDNKGILKPIEHTVKSGKAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFS8</accession>
    <name>A0A6A6RFS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_521915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFS8"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2503334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="38106" checksum="ABA57671F71A2F3D" modified="2020-06-17" version="1">MTSQTPHRPQMRKTRFVCISDTHNQTPKLPRGDVLIHAGDLTNQGSLTELQKTVAWLEKADFEAKIIIAGNHDITLDAPFYHAHGTSWRFPEPQDPAACLKLLAESPSLTYLQHQSASIRLRSPTGPHTRFTVFGSPYSPTLCQWAFQYAEADAAELWDAIPEDTDVVITHTPPRNHCDAAGAGHSRGCEGLRRRLWRVRPRLAVCGHIHEGRGAERVRWDGNGEEGCLEEGSELWEDTSAGSKKQSLVDLTGKGNGKGWRGLGDDGVETRHDIASLGLGGQSKGGGQPGGAGLTREKGEEKVRRETTTCVVNAAFMAAGYGEGPKRFNKPIVVDMDLPIWTDGDDGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIK9</accession>
    <name>A0A6A6RIK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_449143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RIK9"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2503317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37398" checksum="BD83CCAE3539EC15" modified="2020-06-17" version="1">MRLFLLPISTRRTLIYCERMHEKLASERSYLDKITNKANETWALWEKDSKSIANWKKTVTVYGNKAFKRIPFEEWGLKTVPALTAKRRKLELEGKEKVEVIFPRRFVHEERVPGILRQLATERQALHKKRMIGSIAAMPFSAPFMLIPVVPNIPFFYLVFRAYSHWKALTGSKHLQFILENKLLKPVPSSELDEAYAAGLMYPTRELSRAAPLPTQEQVDEISNIVGKQTNDGSEDVMVLQRWNGKLIAERFKLPEMEIEIERAVEQVETAIKGKEELLEEKRELERATASPDSVQTEEPADKKTPSEKFGETLREKKSDVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q988</accession>
    <name>A0A6A6Q988_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_600811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q988"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="24747" checksum="51E9E833B84A16E7" modified="2020-06-17" version="1">MKDDGFDYSHAKVLLQRNRQFFVATVEPRIERKEEIDTSNLETTPIPLEHIYPMLPTQAPNSLSVDVYIKSPNIFEYGDCPGLTDVSNLIMHEAQMCERTRRSPHPNVARYFGCHIDESGSIVGLCFKKYSQTLDELVEADEALDLPKCLSDIKAGIEHLHSLGIIHCDIKPHNIFLDESTFVVGDFDSCAFEGDKLGIKAGTQDWTNEDCKLAQREND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9J5</accession>
    <name>A0A6A6Q9J5_9PEZI</name>
    <protein>
        <recommendedName>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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    <name>A0A6A6QAK0_9PEZI</name>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2489478.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2489455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128087" checksum="62583D435E948B29" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBC5</accession>
    <name>A0A6A6QBC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_180163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBC5"/>
    <dbReference type="OrthoDB" id="10457879at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025478799" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="39593" checksum="FC4A0BA35601DC3A" modified="2020-06-17" version="1">MFPLHMLAALPALLGSIATAGAVPEPIITAAPRLAKRQDEVSSPDFVGYFTSEGESTYDVWTCLGTAYGEYTASDGIYGGCWSTDWGFYGTSCDADTLYGVSASTSKDYTTSFAASITCGYTCVYDYLVSTPGEEDTSFFPECATESRDSYTFIRDYYSDLPAIGSAATTLDSAAATTLDSAAATTIGPATTDISTSGFTTTTSTPTTTPTPTPTPTPTPPPSPAIHPRKKTPIAAIVGGVLGGLIFLGVASALSFFLWWKKRRNTAAGPSTLHAPPVLMTGGVGGGASGAGGYYTSPPEKLAMATTTPASMGPSPASPPPPIYAAPSHAGWGNANVQPQYGVVSPPQDVYHELGGQPQVGAPVGAQQQQPVEMAQPPARHAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBK2</accession>
    <name>A0A6A6QBK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBK2"/>
    <dbReference type="OrthoDB" id="10375388at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="114" mass="13001" checksum="7B91B6ADD5AD88B8" modified="2020-06-17" version="1">MCPRRNNRRRGPIATLVLAGVALGTKKVQEKRKAREEEKATRAIEGELNYEEARRSAIQDAQMSRHSKEIEAQEENPPDYDNVPAWDYTTTYENKMDSGYGGRGIMVGDEKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCE0</accession>
    <name>A0A6A6QCE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_471787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCE0"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489127.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="403" mass="44217" checksum="2B9E0D93BB0D3EBC" modified="2020-06-17" version="1">MAPMPSALSYELLAKCSVTKARAAILHLPHGPVPLPIFMPVATQASLKGLTPEQLEETGCRLCLNNTYHLGLKPGQATLDAIGGAHKFQSWPHNILTVSFQMVSLLKLAKVTEEGVKFLSPHDGTPMLLTPEHSISLQNSIGSDIIMQLDDVIATTSPDLARMEEAMDRSVRWLDRCIKAHKYPERQNLFCIIQGGLDLDLRKRCTKEMVERDTPGIAIGGLSGGEEKAAYCKVVDTCTSLLPEKKPRYVMGVGYPEDLVVSIALGADMFDCVWPTRTARFGNAVTSTGVLNLRNASFQNDFTPVEEGCTCVCCRPKEDGGLGITRAYIYHVAAKETAGAHLLTIHNVQYQLNLMQRARQAILEDKYPAFVKEFFGKLYPDKTKFPAWAVEALNGVGVDLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDL8</accession>
    <name>A0A6A6QDL8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543814</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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            <begin position="13"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="166" mass="18691" checksum="6F10BD549F053AE7" modified="2020-06-17" version="1">MESPNWLSTTLSVLYYIILLPIVKLTQFILLVLLPLWRLIQWILLPVTHLARVLLGVALFPFHAQLLSRFETLYIYLGVAGLVGSITGLILFTCFNFLSTILRIDAATEDKQAQGMTAASYRAARRRKQAIQPAYPLSPTVLKEEVTGPHRNLLAQTIVEEEDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QGV8_9PEZI</name>
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            <fullName evidence="19">EF-hand</fullName>
        </recommendedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
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    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="17">CBS 269.34</strain>
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        <text evidence="11">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
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        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
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            <topology evidence="3">Peripheral membrane protein</topology>
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    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2491655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1480" mass="157883" checksum="0C7D3DE16117E4B9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHB1</accession>
    <name>A0A6A6QHB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-hydantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_468929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHB1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF96">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="55"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="492" mass="54766" checksum="4398ADBEBCF37A46" modified="2020-06-17" version="1">MAEYDLLILNGLVVTDRETGEYDIAVKNERIEQVVPRGSFKNATAKRTIDAEGGYVMPGGVDAHVHLQEPPLFGKGSTADNYETGSRSAIAGGTTTMVTFAPQRKSEDSLLDILSATHEKAKDNCYNDYSFHLLVSNPSPRALSEFKTLREEGISSLKIYMTYEALQLQDGQILDVLVEARKQKITTMIHAENGQVIDWMTAQLEKRKFFAPKYHAIAHPAMAENEATYRAISFSEFIDAPILIVHVSNKAAAATIKSAQDRGLPIYAETCPQYLFLTRKDLDKVGFEGAKCVCTPPPREGKEDHEGIWEGLANGTFTVLSSDHCPFRFDDAVNGKKTCISDEFPLGKFKYIPNGIPGIETRLAFTLSADRLKLNKFVEVTSANPAKLYGLWPRKGGLVAGQSDADINIWYPPDKMEPFALKNEMLHHDVDYTPFEGKVLNQWPRYTILRGEVVWDRDNGGLLGKKGYGQFIKRDASCLAGSRQDGEWDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHC1</accession>
    <name>A0A6A6QHC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_584714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHC1"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="114"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="408" mass="46607" checksum="E655795647603087" modified="2020-06-17" version="1">MILILNRARRKSVAKITRSLNEKNTFSPASSRVSLNPKRSSSPTRETPGILRKAWPPVLTESFTGLKETPPEHVEQLRDRLANGVDSSFIPQGLQNIIDNDPKVSHETIKPADIDRSDTRSTKELMTIWREVKEIFINARECKDESQDENAWFSHVVFPLVRLAMDLYGNDRWGFQWIKSQSINPLYLSTIPAPTLANSTRRKLIDCKSDFVFSYSSRNPSISDLYERFDAAYVHVGHTLDCFTSRIAHFSGFVLKTPSGDATEAELQMSIWIAGSLRNKSELAQAAQISYEPTAMVEPAITIVGHHHRVYYGYPRTNLVCGRSGIHVLGEDSRFGRLGTESIRGVFQLLRFYENMLEYGMDEGRDGYWGRFFGPVLNKLADIAVEKRKIWDRGWQERQRTWNEPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHX5</accession>
    <name>A0A6A6QHX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein rhoA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_552668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHX5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <source>
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    </evidence>
    <sequence length="198" mass="22215" checksum="B6191D8941B3EAD5" modified="2020-06-17" version="1">MTSEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILVCFAVDSPDSLDNVQEKWISEVLHFCHSLPIILVGCKKDLRYDPKTIEELHKTSQKPVTTEQAEEVAKKIQAMKYLECSAKTNEGVREVFEHATRAALMNKQGRGSKSKGKKCVVL</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Daum C."/>
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                <person name="Henrissat B."/>
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                <person name="Mondo S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKV3"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2492872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="136" mass="14525" checksum="212864A4B98A51AD" modified="2020-06-17" version="1">MVTKGSCMCSQIAYEFSGEPATTALCHCTDCQKWSGAAYTANVVVPRKDFSVTKGTPKTYDAIGDSGKVNKHFFCGNCGSSLYTELEIMPDVACVKSGGLDGGAANHEVKVEFYTKDRLGYAKEVPGADQVTQFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLE8</accession>
    <name>A0A6A6QLE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_97845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLE8"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="217"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="646" mass="70800" checksum="9B79E6600E4C8FAF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLH7</accession>
    <name>A0A6A6QLH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_564209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLH7"/>
    <dbReference type="OrthoDB" id="10414569at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025623495" evidence="2">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="118" mass="13311" checksum="4310B380A55B8C60" modified="2020-06-17" version="1">MLTKTFIVALLSYIVIAVPVSFAEERSQCARNEGQVLTKPFETYSEFAATGKRDEVESGGQWKREHLEGDHIEALPFHVDTSLSQHNKVEGGGQWKRQEEVEGGGDWKRDEFEEGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLI0</accession>
    <name>A0A6A6QLI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_583907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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            <end position="225"/>
        </location>
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            <begin position="283"/>
            <end position="299"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492840.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="760" mass="86187" checksum="A84D67BAA75EDDC3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLQ9</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
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            <end position="309"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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    <sequence length="335" mass="37015" checksum="0CA286715FADEF0B" modified="2020-06-17" version="1">MPLSREAIQSSGTISPTCTAAVAANPISVTGTDILSFRASRAEHLKALRHLYPIPGPIPEQVVETDHQVPVRDGSKIAVRVYEPKYKREGGSPLILAYHEGGWSMGDLTDEEMNCRMWTRDLGAVCINVEYRLAPEHPFPTAITDSWDALLWAISHAQSFNANLSLGLIVEGASAGGNIAAVMAHMARDAKLEPPVTGQYLCAPAVLHPTGVPEQYRDEYWSREGAESDPVLKKNAIDGILAAYNPDPTSWLWEPFNHPAGHIGVAKAYIQIGGIDPLRDETLLYERELLASGVETKLDLYAGYGHMFHANFPTMQRSRQFWGDMLEGMRWLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLS8</accession>
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        <submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
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    <comment type="cofactor">
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            <name>heme</name>
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        </cofactor>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="527" mass="57383" checksum="C56E5780958A7473" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMK1</accession>
    <name>A0A6A6QMK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_528662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMK1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493354.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="734" mass="80962" checksum="CD23CF0031A2551D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN81</accession>
    <name>A0A6A6QN81_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">BU16DRAFT_584471</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 269.34</strain>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        <location>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="690" mass="76710" checksum="C3CAD30E37CC77F9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNE8</accession>
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        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="15" type="ORF">BU16DRAFT_592079</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2493649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="512" mass="57836" checksum="B4F59157BFCEB77D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNF1</accession>
    <name>A0A6A6QNF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNF1"/>
    <dbReference type="OrthoDB" id="3945111at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="679" mass="75121" checksum="A53BBD3C9D692C41" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNI2</accession>
    <name>A0A6A6QNI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_619136</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNI2"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="124"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2493935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="505" mass="54406" checksum="73FBF983B2927CBF" modified="2020-06-17" version="1">MGENRELSLADVSTHNTETDCWIAVSSKVWNITEFLDLHPGGKAVILKYAGADATAAYEEIHAPGILEEHLSSEKFIGDLAPSAPSNDVAPPSTVQEATKAEETPPTAPQTQVTVTVQQPTELPALYSLIAAYDFEEVAKRHFTPKAWAFYSSAATDLVTHHANKSVLRRVMIRPRILRDVKEVSIKRKILGHDSAAPFFISPAAMARLAHKDGELALARGAAAEGIVQCISSNASYPLGSIVNAGVDGQTFFLQLYVNWDRPKTAELLKKAASLGVKGVFVTVDAPVPGKREADERVAAEAVASAISGAVASNDKKGGGMGRLMAGYVEKSLIWKDIQWIKEVSGLPVVLKGVQSAADTMLAVEYGAAGVMLSNHGGRSLDGAQPTILVLLELHRVCPEVFNQIEIYIDGGFERGSDILKALALGVTAVGLGRPYLYSLAFGSEGVEHLTQILKDELETSLRLCGLTDIDQLHPGLLNTQDIDHMVTNEANRHPWIKWEPKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNT7</accession>
    <name>A0A6A6QNT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_528308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNT7"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000008">
        <property type="entry name" value="Cx9C motif-containing protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="78" mass="8717" checksum="02022A72B523E6BC" modified="2020-06-17" version="1">MGLKDDLKTDPPCHPKACAIQDCLQKSNYNEDKCRSQVDALYECCNEFYKENGDSASTVSCPKASLLRLKMKQKAQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNU2</accession>
    <name>A0A6A6QNU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_55355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNU2"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2493786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="353" mass="37707" checksum="02BAFD628AB80270" modified="2020-06-17" version="1">MAQKNPSFILHSQGKVLFEDRPIPELKSPYDVLVEPQWTGICGSDVHYWVHGRIGHFIVDAPMVLGHESAGTVSSIGASVTSLKVGDRVAMEPGVPCRRCVRCKDGKYNLCPDMAFAATPPYDGTLARYYALPEDYCYKLPEGMSMEEGALIEPTAVAVHICKQGGVKPGDSLVVFGAGPVGLLCAAVGRAFGAKKVVSVDVNEERLKFAKGYAATDVWRSKAGETVEEGAKRLVEECGLGSGADVIIDASGAEPCIQMSVHACRIGGTYVQGGMGKPDIQWPIMAMCTKELNVKGSFRYGSGDYQLAVDLVASGKLSVKELITGKVKFEDAEEAFKDVKAGKGIKILIEGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNW3</accession>
    <name>A0A6A6QNW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_528006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNW3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="63" mass="6676" checksum="E8D914392772CDFB" modified="2020-06-17" version="1">MTQEAVANVYGLHLRMHTGGMQNYGNVSGTMLRSFSITGVSGVGIGTWKISAGTTRDVTRSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPA8</accession>
    <name>A0A6A6QPA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPA8"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20163" checksum="758EA71708E81375" modified="2020-06-17" version="1">MASTEPHPDPVALTASNNTSKVDYTPYPEKSIPVSSEQQATVDAICRLYSGSASKDDMQVYAPTAIYDDPWSYCDNRYKVAGQWYGIPKIMASSRTLATEIVDASPSLLVFKLRQEYTPRVLNIGKAVNSLVSLSLDKEGKVTYHKDMWNEKDYSHEGLGKVMKTLNGDYLTKITRPEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ51</accession>
    <name>A0A6A6QQ51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">White collar-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_464343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ51"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45232" checksum="27B01D1742FD57BC" modified="2020-06-17" version="1">MSGVGAGPLPTGFGAQNMNPSGSTLTEFTKRRNWSQRVLDELRDFLHILTPDGRIMYVSPSCKYITGYEPVQLVGRFMNELIHPDDSGIFVREFNESIASGNPLRFFYRFRKEDGSWIIFESHGHPHLSTDGTFAPNGPTLCRGFFMMARPYPTKNAALLDSFLEHKIENERLTKRIAELKREEQEEEEQQDRHWSKQMEGYSSVSQSETQRTDTESSAFNESKAMPPPAKPVALNTALTRQNLDEALSATKADSINDKMARYEGATHLETIEMLTGLRYRDGERSKGISTGDASPLLIRGDVGIQISLDKDQRGSLDKKKKMKIADEYVCTDCGTLDSPEWRKGPSGPKTLCNACGLRWAKKEKKRQGGNTSISLPANLPQQPSGNQSIHTNSNSNTTTNTNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQV8</accession>
    <name>A0A6A6QQV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_42568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQV8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="165" mass="17790" checksum="138AA7F39E5D3DA4" modified="2020-06-17" version="1">MRALVGVARRGFPGSAPPSCPVCPARHLFWRLPATDDLQHHTTPRRYHTRLQEPALRALAILCLSPQLHLTIAYSGGFRGPPLQIHSPELGPSSPAALPSITQASAPRVALSPPDARPISAPRIRCMLPVHVRSAAVSMSCPKKPCCSACLLWLGHNLSTHSTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRH6</accession>
    <name>A0A6A6QRH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_511343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRH6"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025368212" description="Glucanase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="440" mass="46551" checksum="97A21ED42D664B5F" modified="2020-06-17" version="1">MRTASAVVLSLVVSYTTAQQPGELTPEAHPSLSSKRCTLAGGCVSVNSSIVLDSNYRWLHNVGGYTNCVGSSGFDPEICPDIETCAANCTLEGVDYATYGISTSGDALTLDLFVQKDNTTSLASPRVYLLENDDTYVSFNLLNAEFTFDVDVSNVPCGINGALYFSEMDATGNKNALNAAGAAYGTGYCDAQCPTQNFIKGEANLNSTFGACCSEMDIWEANAAATAYTPHPCNTTGVYACSGTACGDGDARYAGVCDKDGCDYNPYRQNATSFYGANLTINTSRPFTVVTQFPTHNGVLTEIRRLYVQDGRVIHNARSRVAGMGPFSAVSDEYCREQKEVFGAEDAFAERGGLGAMGEALGRGMVLAMSVWDDSGSGMLWLDGTPADAVEGAPGAKRGPCGRDSGDVGALMEEFPEARVVFSDIRSGEIGSTFRGRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRP2</accession>
    <name>A0A6A6QRP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_82936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRP2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="497" mass="56067" checksum="8007789D0E8EC371" modified="2020-06-17" version="1">MSFTQYPPRGHSFLPVPASTKSNTRPGDKSKADRSGALTSRNHQNSLPVSHVTSKACRQCVQRRHSDGSVVTFKCDDCIPAALNPSGSPVSSSESREARTASDIWRMKDDDEERIVSLGALNKLFFAGKDLVRSRELLKDDEREWSKAEDYSKKMVGEPPSKRDEEGITTDAHALRFASNQRLRGLIPDMNEDLGDKILDLMMASGDAASISSHKVSCKRGIISIVALLGTKLSILLDVINIIGSNKLRHDVELDIELSFIPNLDSAKRQANALTAGTKSLAQIFQAKFTWDLRPWDLRTWDLTPGTWGLRPGPRAILLLLNPEVQNPLTRFLKLSRYEKPEAAPERRRNCRTTRLPFERHPRETKTAIYNTICDQRSELLSVSDSNISDDNYMLWGKAKGAIWKQSQGRSKEWRCCKLSKASNKGQYMTKNGPLLKKEMVTVPINAAPITFQRRDKGFRPVSWVLRRVKSDVHRRCDAKTLVDDADVHEQWEYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRT3</accession>
    <name>A0A6A6QRT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_562474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRT3"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Bloem J."/>
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                <person name="Goodwin S."/>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
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    </reference>
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    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
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        <location>
            <begin position="86"/>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="949" mass="105729" checksum="62906C4CC0A90DDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTD3</accession>
    <name>A0A6A6QTD3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_462273</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32031" checksum="FBF1573510D0D83C" modified="2020-06-17" version="1">MASAGPKSAGGIVPTRLRQVAFVTDDLAKAKRLLTTILGTEIVYEDPRVGAFGVANFLGMELFAVGGDIIEVVAPTTTLRASTTAGRLLKKRGEGGYMIIMQSEDAAARREYITSNGLGKVILNDEHDDVVSVQYHPSGMKGGIIPELDSHRPSKDNPKPLTSPFSPWHACGTDYKAYSAIMKRNTHIQLGGLVCRLAPGDVRHEEAPRQWEDMFGVARSRDLLAFTNARLGFMRGEEGKPEGIVSISIGVTGQDTLQGILDRASKEGLLENGWVNLLGVKWSFYLASFGTAKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU45</accession>
    <name>A0A6A6QU45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1750-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_539578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU45"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="724" mass="78051" checksum="7D0B25CE5942736E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUR6</accession>
    <name>A0A6A6QUR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_526666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUR6"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="279" mass="30364" checksum="D366804C731842B1" modified="2020-06-17" version="1">MKTAFGRLVRFKSKGGEVLYGEAPTGDDLVGKTVELYEGEQPWELKATGKKAEIAEVLSPLPAAPIFYGIGLNYKAHIAEAGFPTPGFPTVFTKPADALAGPFEDITIYKDCQKTMDYEGELTVIIGKPALNLTESDDPFDYILGYTTGNDVSCRYWQMPEQSGNQHGYAKSFDQFGPIGPVLVSPSLIQDPAALTLKTFVNGEERQSTSTSDLLFNIPQIIRHLSRGTTLRPGTAIMTGTPSGVAAFMKPPAWLQDGDVVEVKISEIGSIKNKYVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVC5</accession>
    <name>A0A6A6QVC5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_358538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="14615" checksum="5EDB62859BDD85BF" modified="2020-06-17" version="1">MTRLNKDPVELDALQDLVELDALQDPLDSDDSYGWDNDITADVLTELSPHLRSPAAPSSTSSNSAGPTASTVPTGDSLATSSKGMAVESGRQRTTILCSRPSADTSRAQQPPHPINLAPLLYSPRAPPRFAGTYQALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXP0</accession>
    <name>A0A6A6QXP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein cwf19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_538954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXP0"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="445"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="578"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="78456" checksum="6C27E652EAC4CB3E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY01</accession>
    <name>A0A6A6QY01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_549301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY01"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="292" mass="32667" checksum="EC3E21A07947FA3D" modified="2020-06-17" version="1">MSVSASVYDYRYENGRRYHAYSEGKYLVPNDELEKDRLDLQHHTFRLTVDGALYIAPIPKNVQTVLDVGTGTGIWAIEFADEHPSATVLGTDLSPIQPDNVPANCSFLIDDADHDWLFRTQFDFIHARAMMAAFKDWPRFFQQSYTNLKPNGFIELQEFHLPPICASNGALNTHPAISPNPIIAWGQHLSSAGSKIGLDFSAAASFGPLLQAAGFVDIHQKKLKWPYGPWAKGEKFKLLGKFARQDLNDGLGSSTLALFTRVLGWSREEVEVFNAGVRKELREGVEGVWQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYH3</accession>
    <name>A0A6A6QYH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_316011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYH3"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="303" mass="33278" checksum="713E1C42D15ABEB1" modified="2020-06-17" version="1">MATQHRSAHHPKKQLPAHARPSKPAPLSKRSHSYGGHKGGRKADHHKEEDTEDEEVMASSFLQYCTTCEKQIIVPNNLVLYCSERKKDNEKVVSYSIDYSPPPTPYSQFSFDDFPTRDIVAPRSPTAPHSQRSSIAFSELSSDDNANSGDEKLRQDSEASRYLRQFQSAAAKTETSATRPTRPRYNRASTSHATMSAAPSLSHTPASSASMSMPYTPSNRPLPPRNNPHSSSYKGYGSRSIDLVMPFTTGATAPSSLNYSLKSAASSRTELGVVEGEIRYEKVARIPSVSPANGSLKQLFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYL5</accession>
    <name>A0A6A6QYL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_616165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="62314" checksum="000615FD2E8E8240" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZD5</accession>
    <name>A0A6A6QZD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_561302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZD5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="18105" checksum="F813A376FF299861" modified="2020-06-17" version="1">MPSKIAKAPKPALPDTISALNDRLWDDLTFQGRMMHVTIASAYDFKATLPEHEDEVNARMRSWIIARYFPKLNALEIAVLQSTSQNLGAALWATLKDAFKQSPLEEDVIFTEMLAFVMKFGNDTQRKSMLYMYTVNQGLEGCFTRKMREKYMKVTNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZK7</accession>
    <name>A0A6A6QZK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_548886</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZK7"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="306"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2497885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="51015" checksum="482B60DEAEB4D9DB" modified="2020-06-17" version="1">MSVLDLLPHCVSGVYFIYHSDFEQWSFGKLSALREAALALEAGYKYYYMGYYIHDCVKMRYKGHYKPQHVLDPETYEWVPLDGEFTSLLDQKPYVSLALEKRLKENGTTEPGAETLDGDADCFPLPLPADAAAAVTAGTSLFDLKVPGLMTEEEIAETVDLGKISLRGQGRKPIKNLPEETTVGREDSAAELYKSIAASSKTSVHRLKITKGSDGSAIPNSSSVTVQDTGLRNKSTIDVKDLGPQISWRTVFVVEYLGPLIIHPIFYLLLTRPPSELQTISLLMIMLHFLKREYETLFVHRFSLATMPALNIFKNSAHYWLLGGVNIAFWTYLPSAPTAKATSPIFKYAGIAMFVVGELGNFSNHLTLRDLRRPGSTERGIPKGLGFSLVTCPNYMFEALAWLGILSVNWSLSTAIFAVAAVGQMAVWARKKEMRYRKEFGAEYKRKRFFILPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZN6</accession>
    <name>A0A6A6QZN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_323663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZN6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="160" mass="17911" checksum="6FA92DEFA56A0652" modified="2020-06-17" version="1">MALSIAIADQGRWGYPSPGSAESRAEARRAMRVHRTVLDTGSSLRSMSDARYYVSCGAIEQRAQRRSLLAWGYSTALHRNAPVVAIRHGFQFLQRAAWRPRAFPCFRPHSGTNRSSRRRLIPQIVEKQQSSSQATPSTRPLVCAHIGHQFGRQVPDNVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0H7</accession>
    <name>A0A6A6R0H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_538045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="209" mass="23278" checksum="835B47F940351156" modified="2020-06-17" version="1">MSSATAGYDVGRENIDEAAEDTKRGAEGSLSRYRFGEAAEAVGGRRWDKVLTARELRGLREAGGRRRERSCPPRSLGNRGKEVAAKQEELEYEAQKKRSLYLMDIESRKRASEPLRHITTKIGTPYDTSSTADQELGEPSNPYLAFHLAAMTLPWWFFPQWVGIAAAICAVGLHGRRSPPHQALDLPCKNPPIDASIPTDLSRRAYEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1H7</accession>
    <name>A0A6A6R1H7_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Oxidase cueO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_455858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
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    </dbReference>
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    <dbReference type="OrthoDB" id="262547at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="608"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="68317" checksum="94E88934A0994F8B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1X5</accession>
    <name>A0A6A6R1X5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_570967</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APH"/>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="101"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="438" mass="48705" checksum="EFC077C65C5F91A0" modified="2020-06-17" version="1">MAPITKRCPSTNWTSYDSWDYDGMKERLELFMSSIDKSALLKHVEQVTGKATTMSEPFSAGQFWCCFEFILSDESLVIARVRLPRHPESNERVSDESELYAIECEVATMQFVHERITSVPSPCLYAYATPGSQQATDVGACYMLIEGFYGNTLQDVKFDICDLPIQDQEHILTQWTSIQAELASFSFPTIGSIAQFTAETGPTIGKLASAAAEGFEAAGPFLSAHEYFTAVGNARYLEASKSAEDDDEEEADIYTVLGPFIFRDIVQHTDLFKGPGNTGPFHLNHMDMGTQNILVDDAFNFLAVIDWEFAQSAPVEVNHYPMPFPLISSDAEIEQILSSPGGVAHRNVQRHVKARASYRHSFEAAEEALAGKGRPLQRSIAETLDGPASRIYAALEKIAVFDGMGEELTREMVRLGFRLIGEDADEYVERMKTTMKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2E3</accession>
    <name>A0A6A6R2E3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_455136</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
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    <name>A0A6A6R3V4_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lutzoni F."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="55181" checksum="6898D1AD62800BC0" modified="2020-06-17" version="1">MPAFDDSDFGVQGPISPAKSHHDSPHSLRKVASRNSHHVGSHGSLAIPSEVNGGEHDAIEVPATRSSISDAQSYMHQLSLSPSMKERRGSRNSFGTSLPIPRSKRQSRLSSVSRPVRPGMPPIQPTRDILAAQVQDLSSEKVQAAKDMAFVFDIDGVLVLGDELIPEGQRVLKILNGDNELGIKIPHIFLTNGSGKPENARVNQLSKILKSPISTDQFIQSHTPMRALSEYYSTVLVVGGEGYRCREVAEEYGFKDIVVPNDIIAWDPTIAPYRVFTDAERATSRPRDFSKVNIEAIMVFSDSRDYATDMQIIMDLLRSEDGRLHTVAKDPVSQRIPIYFSQGDLLCPTEHPTPRMSQGAFRIGLEAMYKAVTGEDLERVVYGKPELATYRYADEVITSWMEQIHNDEKLPKNVYMVGDNPASDIVGGNMYGWNTCLVRTGVYQGEGNDDENPASFGVFKNVLEAVQTACRKQLGDDFQFGFNEKMNPVLHGNGNSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6X4</accession>
    <name>A0A6A6R6X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_452214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6X4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="573" mass="62955" checksum="431012158DCD6BDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7B7</accession>
    <name>A0A6A6R7B7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_556836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7B7"/>
    <dbReference type="OrthoDB" id="10328577at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="196" mass="22542" checksum="D0A699B102DDD6CD" modified="2020-06-17" version="1">MTPAYPPNPAKKWSLCEVLPGNNLIRPIPYKEFAQPFTGTPDARGLVSLRRIWKSELDICTEQHAHLAAFQRVIDRPEKDQERSLVVTHIKPFTLDSRDLVEFSWRYAGDGFTPTILDDSYASPWAVETAWYKFYLLGKLSPQLEAWVKRTVRPPEIDGDVRESTYWALGKFYTADLRKGKVAALWLRDSEEPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7F0</accession>
    <name>A0A6A6R7F0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_556780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7F0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="19091" checksum="F36BA125E231810A" modified="2020-06-17" version="1">MSYPALALAAPSSSITKRLTDPIMAAPSVEVVNWRAETTKRLIPATDSTTIGPICRAFIMAACMRQPEEHGLDYIPSAKPSYSKVLGEQSSVPRFASRGSTQLNPTRRRTTQAQLTCALRQLWSDPWKHKRVDHKPANASPLRNPSNSAPWLKLTLHLLQVRQNSSWRDMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Z1</accession>
    <name>A0A6A6R7Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_602334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7Z1"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="234" mass="27073" checksum="C0700D4727FB32BA" modified="2020-06-17" version="1">MPTNLCNNKMTRRKRKWANGHHEPKKRVRKWKPAGPFRLLDLPRELRDMVYGRILVPVKPDSQVSETPIAYADPPGLKFGENGITHNFLNKPNLLPQVRPLTTTRTAILQTSKQVNEEAREILYESHIFQVDMDEGLWRFDTPAPADEDENTEEARLKVQYEQHYHHDTEYAESALLREAAAASIGWELSSIRRMHLHIDLRGGWSSWCPHRNSKGLAPPHDILHIFNYSGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8J3</accession>
    <name>A0A6A6R8J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_547469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8J3"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2500722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="576" mass="62460" checksum="0CDDFF3B0F304C53" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8U4</accession>
    <name>A0A6A6R8U4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">BU16DRAFT_523590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8U4"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="115"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2500842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="302" mass="33367" checksum="AE98295D128FC1CA" modified="2020-06-17" version="1">MSLKRKAAELATDAKKAKTASQGSITSFFGAPKPNPTKAATAPAKFDKEAWVEKLTEEQKELLKLEIDTLDESWLAQLKDEIVKDDFLDLKRFLKKEVANGTVYPPMKDVYSWSRHTPLHTVKAVILGQDPYHGPNQAHGLCFSVRPPTPAPPSLKNMYKALTKDYPDFKPPPKNSGLLTPWADHGVLLLNTVLTVRRGDANSHKGKGWEALTSKVIETVSRVRSNGVVFLCWGNSAAASVSKINSTKHHILKSVHPSPLSASKGFFDCGHFKKTNEWLVTRYGEGSEIDWNLDVDPEVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9A7</accession>
    <name>A0A6A6R9A7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_235198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9A7"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025470873" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="16354" checksum="E37A391E1AB5309D" modified="2020-06-17" version="1">MKISILITFPTLSTILGLAFAAAIQEFGMATYTIKGTPSNTTSVEEVPPGSGVYFCPDKEWGHLDHRENLCAWISARYFDEGAAICINFVDGYDNTISSFGPDRGLKCTVYDFSYCTGPSLDIWWPGYADMSWNGWDNRVSSYRCAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9D5</accession>
    <name>A0A6A6R9D5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9D5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="9932" checksum="4676FEC530804E14" modified="2020-06-17" version="1">MAEEQQSKGMFGTVTSGLGNVGSGVTNTVGKGVGGVTNTLGDTVSGVGKGLGDTVGGVTKGVGDTTKAAGGMVTNTTDKAGETMGGKKADAGGKKSDDENHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA63</accession>
    <name>A0A6A6RA63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_556048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA63"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="34396" checksum="726B295FB100F55B" modified="2020-06-17" version="1">MAQTRSATGYLSHEERTVAEVRDPNLHSVILESIELVNERIRLLKLSVKDQRRGIQFLPGQWLDVHVPGLKKAGGFTITSTPMNSRPQTPESTTDESRSPYLELAVQDSPSNPPAAWLWRAPEEIIGRELKVRAGGSFVWPPPGINLDQVKRVVFIAGGVGINPLVSILSHIRESNVQLDELRFIYATKISKQDPKESEILFLPRLLDNFKLPHTSNDGPRKERLDLFFTGHQGNLELAKDLPPQTQFRRLGDRDIEEAAGTVQEKQSSLFYVCGPPTMTDHIVDFLKKQDSVRPDHVLCEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB58</accession>
    <name>A0A6A6RB58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB58"/>
    <dbReference type="OrthoDB" id="10332913at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="30979" checksum="4A89768DCBEE7DF9" modified="2020-06-17" version="1">MAQPATLQQNRTLMAAAMLPRMVQLPGRQLPYRQLAVIAFVISKMTTFTKEISFGTWPGSIMGFSLGFGSRIPGKIWASLPLLHVCSYIRGVVLPKILSNNRFKACGLDAYGFFCGQLPTPLLPFLHHVTISVQNSINYLRDRGGLGALKQYNGLRSLTFVLEPILPEPMDTTCGRYSREILDALRTIFFDRELATAEPIVALSITGNVATFATGTLLLEAVSTEPEDRDPETTARLIAPIRLILQSRARNELFRAERKQAIADRRQWMSANGVPFPSL</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="25"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="27902" checksum="0494AE485DA94141" modified="2020-06-17" version="1">MKTSFGNTILAVLVLGHSFGSARFADDEETATNYSIARLERLRTRGLLEARQSCSDIKCIGDTPVSQMVVMEEASEVPRHERPETRAVLTNFLEKDQLEDQWLDPICKQITDVDSHQEIEAGSFYYGIQGTHKRALSLTHKGEYLDLMVTWEPTEPQLLPLFDNVKVDLCKKAISNATGKDTHTLHYGAMNIEQEIQIQTPPVAEKRSLTGVTRRGRWGNTIAIINIELGDHNKEVDLFNGNGLPLAEP</sequence>
</entry>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
    </feature>
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        <location>
            <begin position="240"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502441.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="556" mass="60756" checksum="5EB781A68218079F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RD33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
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    <organism evidence="3 4">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="104"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2503035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6RE48"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="542" mass="62222" checksum="E987C645D6E06B43" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE84</accession>
    <name>A0A6A6RE84_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_546120</name>
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    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00043">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="27329" checksum="27AFC438C17FA9FA" modified="2020-06-17" version="1">MSTSNLLPIQVWGLGGPNPPRVAILLSELHLPYEITNIPFSQVKTPEYLAINPNGRLPAIRDPNNADLTLWESGAIIEYLIERYDTNHHLSFEPGTPEAYHAKQWLFFQATGQGPYYGQLGWFKLFHQEKVPSAVARYLAEVNRVTGVLDGWLAKQETGAGGPWLVGGKMSYADLAFVSWQAVVAHVTTKEEYDLDQYPHAKAWLEKMNKLESVSTLSRTPESPMASVTRYRGVLDDLLRSCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REA0</accession>
    <name>A0A6A6REA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_475681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="497927at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="187"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="352" mass="38685" checksum="6B0A6FDFBDBD536B" modified="2020-06-17" version="1">MSAVTMAEGDTDGVDFFTMGMFIIDEIEFLPPKPAAKDILGGAGTYSAVGARIFSPPPKSQTLGWVVDCGSDFPSELRETIAQWDTGCLMRETPHRLTTRGWNGYGENDFRAFRYTTPKLRLDHTCLEGKLLWSKSFHLICSPIRCVDLVRNILVMRDQWPEPGKKPRPLFIWEPVPDLCTLEELENCKVALKHVDVVSPNHSELGAFHAKTVDGAGHVDYRAVEALSKQWTQWGIGPDGDGAVVVRAGKDGCYVRDKVVSKWIPAVHGSAEKVVDPTGGGNGFLGGFAVGLVRCGKVEDAAIWGSIAASFAIEQIGMPTLVKAANGETWNGVRVEQRLAEFRKRLDRYVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REE3</accession>
    <name>A0A6A6REE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REE3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="151" mass="16631" checksum="D2AC6C63A6B9F216" modified="2020-06-17" version="1">MNYTRSAEAQELREGFVGVDLFRLQCLIISAVILAYLLNAGASKSSSQSFCGSFEKCRASLWFPWSLERVRSAMPRAIRRSCAAAKVVLRALEMCRAASWLPWPIQGDVHRDVKMVLPTSHLAVLPSLILRLRAAATDSSDSAPVNLHSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REY3</accession>
    <name>A0A6A6REY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_4689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="236" mass="27100" checksum="F360AA4DF7C6E717" modified="2020-06-17" version="1">MTEVRRPASQAVGIGSTVVTVRVSSTNRSQDFLIHDSFLVKSSDFFAAALRGEWRESIERVIPLPDLSPDHFNIYFHWLYSGKIYSAPDGYDKKPVQPQVETEFKGEMSSLVRCWTMGQRLMDTKFMDTVMDALIHLVEDAPSFINAKADVAVIYKETLPGSMLRRFIIEQIVQQCTEEFIDHYGDVELPREFLQELLHGLAAVRGKNRDNKPQWLKNPCAFHEHKREGKACYKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF97</accession>
    <name>A0A6A6RF97_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_39151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
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        <cofactor evidence="2">
            <name>Mg(2+)</name>
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    <comment type="cofactor">
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            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="337" mass="37406" checksum="7C8DFF28FC04D6D1" modified="2020-06-17" version="1">MPPKPASIEATLAAKLAEPPAQVLEESHYQPKAQSYWAYDGASWQENTSTIAIGSTKVSSICLITWNIDVLTGGAEARMAAALEHLESLISSVPASQPIVVFLQEMGQSDMAQIRASNWIQARFFLTDVDERSWGSPLYGTTTLVDRRLLVSQLFRVPWVTKFERDGLFVDITLHHESDRNTRVLRLCNTHLESLVADPPIRPLQLASAARYLHEEHVHAALLAGDLNAIQPFDRTLHSDNGLKDAYLELGGAEDSEEGYTWGQQVPQWMKDRFGCSRMDKVLHCGSVTVTALQRVGVGIKVAEDKRRGLRDLGCEEWVTDHYGLMATAEIDSAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFZ0</accession>
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            <fullName evidence="2">HET-domain-containing protein</fullName>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
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            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="599" mass="69565" checksum="0C9C339F2C8022DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG03</accession>
    <name>A0A6A6RG03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="4412445at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673:SF1">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="177" mass="19989" checksum="C5AC27C6AE1150E3" modified="2020-06-17" version="1">MSAPRRSSAISERLADGVFSSATVDDVTPSQQIFAFSFTKQQHPNWPFIQLLCSCRYLFFSIDPFIILLRLLNQLGIRKMDCIPLPIVCFQCGTDQNPCHCKVVGPTIGFAVTVVMAVVCWPASLFCCCCATETGKQYDSPSPPRDVVWDYPDAYLGFLRLRWIQGTRSVMRYRSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RHW3</accession>
    <name>A0A6A6RHW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_27762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RHW3"/>
    <dbReference type="OrthoDB" id="3937159at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2503057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="389" mass="45857" checksum="ECC62D75C5A8240F" modified="2020-06-17" version="1">MVVRRSTRPTKAPERLVDLKVTKPKHRISKTFRIRRINGQPPALSPLERLPAEILQEITVLSNNHFLPQASSLVGSKLSCEHIYMHFCFQGFFYYHDNAPSPIHQRWLFSRRWMTWSLFQNYAIKAYEEYHRRVYDGGTQCGYPISRFRPEVCFIKREWNRFGRPELRPPNFSPSNEDTDTFHPYLNAIHCRIPPKLLHGPFTADKLAFLRFLTTNPVMVRHTMDRKGYVFSSAWQEGLTLGNYDLLSLLLSHRLKRAVRPSGADLMNAVETYNSSRLILKLLIEKMVQRRAYVFSDPTLTDCVRRASDKDGLNRSWLLSWIQRAQDWQYEADLAYPRRQTMFHQMMQIRYLDIFTLDNTHLNDLEVGKEQLEEEGTRVRLSEANQAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7T0</accession>
    <name>A0A6A6Q7T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_225747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7T0"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="190" mass="20369" checksum="91D86B0F9ADB22C5" modified="2020-06-17" version="1">MPLPLAPPSSTDPPPNQHFNTGISPNDHASYMRLALSYAHESPPLPTNFRVGALLVDSASNKILTSGFTLELPGNTHAEQCCLSKYASEHDIPEERVGEVLPEGAVIYTTVEPCVKRLSGNRTCVERIVETRSKGGGIRKVYVGVKEPETFVGDNQGRKILENAGVEVVLVGGLEKEILRVATAGHVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7X6</accession>
    <name>A0A6A6Q7X6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_228420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7X6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="73" mass="8475" checksum="0B720A0422EE39D4" modified="2020-06-17" version="1">MNRQLQGYYPHIIVTAFYCDTSIVIQFLYVRANDCYPNLFLRPAHIINACVHLVFPVFHIRATLESTPIPSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9J9</accession>
    <name>A0A6A6Q9J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_545346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9J9"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="218"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="463" mass="52510" checksum="6B750E47D9C155DE" modified="2020-06-17" version="1">MYTKQKLRSSRTRINTTSGKMLYSSLIAKLEADCPQVEARGIARGAMLLSLLPNLEDLRVTAFGHDVSSDLLLCRPSDRMASLANVRNGNHFPHLHRYTKSWYFQLGVTTPAASQSWLLHVGHSQTPTKPRQSIELVRLQSAAPTSPTSLNTLSPKPQYLSSQPTPQRRITATMPSWKRLKYRRNKKLRARAAKPQPASTGLEKESAAPRPPTPPTAFPKFQVLPAELRLNIWRFAASPPKWQPIRRWVALTYQVKTNTHLMKATRPISITVRPGQPGVLFVNTEAHNEVMKDFGKQMRLLTLAMSDNEAPRQIYFNYDYEILYLPGKAFATKSNAVETMAFWSTSTTIPVEQRDRVRHLAVGYFDETSLSVQGGRLAFCDGLRKFGQLKSLRMVLKKETPCLKTKQGAFERHHGDQPEAFFRRMIEDMRRQHQDFPKVRVMVGYEGSEGQRGQGARRGGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAN5</accession>
    <name>A0A6A6QAN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_174579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAN5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="118" mass="13340" checksum="ECB8DE6C8343796D" modified="2020-06-17" version="1">MEWRGQVYNTISRRKATYVYQSIACVLRIQSSGQMWWFLFGVLMVKLGINGVCSPAVCGISDPQYHGIVKLWNPSTLVLHGSSNAVLQHWGSLFSAIHFSLVFFLFLRHTIPTLPQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBB9</accession>
    <name>A0A6A6QBB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_567477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBB9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="16630" checksum="C1CC64E065239794" modified="2020-06-17" version="1">MTLAHGAARPPLSTPRTRLASVGVESWSLGAGNASQLRALPSYLMYDVLSKANLDAKWLTYMPHTTLQPVSVPQPYEALHTVGDNSMYPRCTWAGSYHGNSLRQHRRHTGSRDALPADMGCGSLCTNDSSTASEKYGNGYPQPSSAKCVVYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC17</accession>
    <name>A0A6A6QC17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC17"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="331" mass="37207" checksum="073BA54667229D08" modified="2020-06-17" version="1">MSDKITSYLTRPGEKGETLGAYARNFGPGFDLQEIVENVHRDGTRVYDKARLAELKAEVEKKAKRVHQLTEEAKPLYTTLFDSSKGSAEGCDALWAHYKGVERASETRFRELEARADARVARAEARVDQLEAMANASNTQMMALTESLANETAMRGSADQALARATQDLTEEKERNAQAGLVMKAVPQLASSMDLLQRKCDELEKEVARGKGLEETVKNLTERVKQSDDAIRKLTEENKRLNNELVRSRIAEAAWAESLDSNEVLRTRAIAVRDRDQLSAALKNMAQDHCQYESDLRYYRDMMNAHKAEAERHKSDAEQATKLLEQIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCL9</accession>
    <name>A0A6A6QCL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_531716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCL9"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="259" mass="28840" checksum="EC4BC93ACE39C868" modified="2020-06-17" version="1">MCSSKPRSPGLAYLGLIDASGPTMAFSAHCAATVANASTSTIATVAELAPAIIDVEWSGPQKCHWQGCASKATFHSPSALKAHIRNMHVTPLLCTHPGCSYKKAFGKACDLKRHAASIHGTESEYPCPERDCKELFSRKDKMMKHAKEKHQLFKCSHNHCSTTVFAAQRESHMEDCHGRYECAMGSCKSGQMSYFTEKNLKRHLRTGHRMESEQVFYALDYSRPKYSNFEEDKALYVGVGWPSPLRDCASCFSQSHNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCS5</accession>
    <name>A0A6A6QCS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="159"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="682" mass="76911" checksum="63E403066E6C690D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDA6</accession>
    <name>A0A6A6QDA6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Peroxidase</fullName>
            <ecNumber evidence="10">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_424036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <cofactor evidence="7 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="7">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU004198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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    </feature>
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        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2490034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="241" mass="25524" checksum="3ABC3EB79CD56883" modified="2020-06-17" version="1" fragment="single">LFRRKDAACPVIWKTVSADLTSMFLDTSTGECNDDARAAIRETFHDCGTWNKAQGSTGGCDGSLILAPETGRSENNGLQDISAKLLALAQKRSVGVADLITFAGAHAIVTCPGGPRIKTYVGRKDSSNPAPNGFLPDVHAAGHSLYALFQDKGFDAVDLAALLGAHSTSKQFHVDPSKAGQAQDSTPGRWDVKYYSDTLNPPANVFVFPSDTALANQTSVGKEFKGFVNNAGKWSGKFADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDG9</accession>
    <name>A0A6A6QDG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="446" mass="51687" checksum="5B01FC99CF2698B4" modified="2020-06-17" version="1">MPTHTVEKLVYDTFMEHKPELRTSGAWRLDNATAPDLTGPVHPMFAQDRWIRTDAGLSGGAKGRPDYLHYDRMLPALRLASKLITTKCLLPWWCHMYTGNPVINYATGVSYLRENNAEHTRRAFDLAASALLRLSKNITIAFQPPIREADFTYGRTWAERRIFPWYSSTHPTTWPDAEPVHNPRFPDRQFLPVVVLNYEYYLWMKNKFPEANMASKIRFWFILAVTLVHEIAHAAWFVSQPLYYQRRFDEPFHQKGDPSAELGFSWEEWVFGHLIYPITGSAEKIRIDPAGPLVANYVDAFPDGSETKHWQGKVRSIPGVTFEAKKTTTKGQLWKALDLSKPENVRDITWAVPTKWIAQWFQRSTWQKWDRLRVGDWVPPPFGPSFVVNIEIVKNGRLTSYVGVKDGKSDIAKVETNARRHDWEKRGDYSADEGGDKYYDDDYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDI1</accession>
    <name>A0A6A6QDI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_531416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDI1"/>
    <dbReference type="OrthoDB" id="5231661at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="82" mass="8736" checksum="F7CC1733B55C3598" modified="2020-06-17" version="1">MSSSQRAKFSTTKPTSDTDSKPPKLKNPSFGGASLKELGANRTVRIVVIIALTIAGTAESIFWAKVLWAKFGPSPKDQGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDP5</accession>
    <name>A0A6A6QDP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_156944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NADH kinase, variant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="432" mass="47512" checksum="708EF8CD1C03518E" modified="2020-06-17" version="1">MKYFVPRRVLPWRRSFSHSSSRRVIKSLSELPARINPKYTETRQNDLLCLQWPSPPRNVLLTKKNNTPEITESLIEYAQHIHSTYPSMNLMLEPHAAEEVHSKLDFPVYTTSTPTLHDAPTPTILSDKTDLVSTLGGDGTVLHASSLFAHTPCVPPILSFGMGTLGFLGEWKFKEYKRAFREVYMSGAHDAYASIDQKDQSEITDSEDANTTPTYASIRGKSMGAARPARILLRNRLRISVFSPSGDRLNSSDPAAGDTYALNEVIVHRGSSPHLKIIDVFVGGRFLTEAVADGMIISSPTGSTAYSLSSGGSIVHPLVSSLLLTPICPRSLSFRPLVLPANTPITLRLSEKNRGREVEVSVDGVRISKGVGVGMEVRVLGEDIRDRRSGEWCGGVPSIVRGVVGMEEKEEDHWVGGLNALLKFNYPFGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE14</accession>
    <name>A0A6A6QE14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_166735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE14"/>
    <dbReference type="OrthoDB" id="10671751at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        <location>
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        <location>
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    </feature>
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        <location>
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        <location>
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        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="956" mass="102810" checksum="8FD9603375FF5EE4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEB9</accession>
    <name>A0A6A6QEB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_133511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEB9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="173" mass="19074" checksum="4D73370A4BFB9EDB" modified="2020-06-17" version="1">MVVPQEVNLHNAQRNTAPTYRIITVRRGGQIIAPQGWLLTNPTGCHIINPQFCTILDPEDCTIIDAIGCDIRAPQGGIITDSTRCDVHKPKNCAIVNARFCNISEPVHCPISNPANCQIKKPRDSNIVDPVSCHVHEPWMCIITGAQDCNYDFSQCEQDHPECQGLGVCIFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFS0</accession>
    <name>A0A6A6QFS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_543674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFS0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="198" mass="21854" checksum="F4DEE48AB62E1CAC" modified="2020-06-17" version="1">MADLNLPSAPSHPDFPPGGPHLHPEYLETQHCVNCGMPHYILGPNHADLLWLSLETGEEEAPAKRRLVCEILRDNVAKKDCEQQMSANLAQAQQRNVVHLQQQLAQVQAELEQLKKLAPLAAAQLGKALDPAAARVLECLHCFKKHLVCDGGMPCSECVVFGQTCRYKKCYKFHNVMHGTVCENPGCRMVHAELGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG64</accession>
    <name>A0A6A6QG64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_565099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG64"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF162">
        <property type="entry name" value="SATRATOXIN BIOSYNTHESIS SC1 CLUSTER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="42427" checksum="2B5C18C28B256312" modified="2020-06-17" version="1">MKLHAFLAVEWAGVAIALTFLLMRLAIRWKIFKRLALDDYLVILAWCTLLPAEIIWHTQIRSYFDKTDSMPPASVYVDHYVSNKIKEGPMWHATYHVLFGVCLWSVKFSFLAFFWNIVDRTHTRGIWWWVVTSITAITFVTFVCLWPWECTGGSVEHLLVYCQTKPQIHIADTMFQVNTAFDFITDGLIISIATRILWPARISLLKKTLLLAVFACIILTMAISLMRIIIAPSHKLSQTTDLPWHWHFTWSVVEMSLSISVACLISFHQLYVSSHGQSMDSSRTSSKSSLRRRLRSTFPMLASWRSGETMGADEVGRSETTLVPLQGVYVRNEVEVERSEGVEERFTAVPRGYPPKTGARASVIAREYEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGC3</accession>
    <name>A0A6A6QGC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_529973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGC3"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="279" mass="29824" checksum="8ED19571E04960B7" modified="2020-06-17" version="1">METTTPNPHDSIVFSEASHSNPRESSLLPKSTPDPTTSSRILTQPQDFDSEPQWLPPGFDKESQKNKVQIRPAYLLLIAVAVVLAMALVGGLAGGLTARRHKSESKEEMIAVQSVGVSSTVELIHNTPLPSQSKPSATSRSLTTSASLTTSTSTPTPTYVTSGTTGMAELPCPYDTSVPYLESTTRTSFNVSCGTDMPEWMTGANGFHVHDDSRFVAYTLEDCLEKCAVTPKCAAAAYGANLTELVEVRGGTGNCFLKNSTVTQPVGSFGWMITAMRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="12"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="135" mass="14946" checksum="CBE1E8EC7B960763" modified="2020-06-17" version="1">MLEHSRPHLHISAEAIIGVVFGILTLTATLASIQFKDSIVRLCCTPRRLRASNDVEANAGTTLAAWPTRSIPLPHSLELYTLPSIRLHWPSPYEISGAQIGEWDRVWRGGSVEEITQRIGPFSGVMRLLGVAHEQ</sequence>
</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="553" mass="59501" checksum="CBCAD113BEF40BDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH71</accession>
    <name>A0A6A6QH71_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Carnitine acetyl transferas-like protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
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    </reference>
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        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carnitine acetyl transferase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="856" mass="94771" checksum="9D928B61D99607B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIA9</accession>
    <name>A0A6A6QIA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_491203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIA9"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="561" mass="62306" checksum="92FD5ED890877BD0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIG4</accession>
    <name>A0A6A6QIG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_128089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIG4"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="273" mass="29454" checksum="6472648A6678C915" modified="2020-06-17" version="1">MARKALIKLTTDSFIIPVKTKSSSSTTTAAETSPPESTDSKQLPSEPAGLPTPPYEKPQDTNALASNLGKRKAADLTPPPSAPAKAVGAGHMAEPPAKRSRPDTNDRGNKVDAKEVRDGDRRDDRGGRDNKRRERSRSPVRGGRRGARRGRSRTPPGRDTKNGARNRSPPRGPRGRASSPPRKPSGKAAAALQSQVPIKVEKMDIDSPGADDVEAQAEYMKKVMGFAGFKTTKNSKVPGNDKLYGVRRETVIKARQYMNRTGGFNRPLSPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIH2</accession>
    <name>A0A6A6QIH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_542571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIH2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="119" mass="13040" checksum="1BD0F4E675AF52CD" modified="2020-06-17" version="1">MARRGATICFTPPSAHLVEARKRIGEQKRGFIPINSQARGRALRPRESHVLPLTATCFGLCCSGILHLGNERDRSRALRAPLPSIYYKTPTSLAETSSPAGFGSLEEQNRALHARMDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ81</accession>
    <name>A0A6A6QJ81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_529430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ81"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="401" mass="45028" checksum="F3CD0AFB51B36150" modified="2020-06-17" version="1">MGGTESKKGGDAPKVPLLIRFFDPEIHSPDARGRTLDDIIEHGDNWFEQCHDYVQMLFPLPEGSPFNFAAPVITRAVFDAFRARPELQAELRRAWVRMMKFYGFDVVQEAAEEGKSKEEADSEVEAEAEAGAESKAGTPSIEEANVSKHDGQAQETKESPDAVQSNEITATEPAMIESGTEVAIPAPEKRIKLVPASNHLKAFQNWVTRFDHNHLRITRVLRSLRVLGLQEECDVYFSMLVTVYEQYGRINERSLIYWKRAVERPLWIAPDDDKVPWLRVACKELEEAKELAEKKSKEVAEKDAVDGHVDGATDGKPPSYNASATTPCKPESAQSEFIEEAKDDFLVEADKAPKKSEETTRSPEDGKWENVQKGDTDKWDTIGKTDGEREKWSRVEGSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJM0</accession>
    <name>A0A6A6QJM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_491821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJM0"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="547"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="695"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="656"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2492299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="748" mass="84059" checksum="89DB79119DC4B9EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJU5</accession>
    <name>A0A6A6QJU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_115313</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJU5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2492502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="695" mass="76308" checksum="CBD7A1068F946C15" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKD6</accession>
    <name>A0A6A6QKD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biotrophy-associated secreted protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_93827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025371602" description="Biotrophy-associated secreted protein 2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="18365" checksum="D143A7F38D5BDF3B" modified="2020-06-17" version="1">MAYKLMTVALVLLNLSLPTLAQGTGTQFITGPCTSDASCASGCCGFNTGKCAGAIIALTRDGGCGFGDATPNDNAAQVLRGQAPSPVAVSATTPAATAAATPAATPAATPAAGGNGAGNGAGKQFITGPCTSDADCANGCCGFNSGKCAGAVVAQERDGGCGFGDASPNDNAAKALTGQKNKRLIVREMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL56</accession>
    <name>A0A6A6QL56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_529110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4738875at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14116" checksum="CE25F53C08B6D47B" modified="2020-06-17" version="1">MAPISKALLQRSPRLSLRRASVADLEAMLEIGLAALPMDPQWDYRFPHRRAYPGDTQKYTRMRYREFLEDQHERWVVMLAEQRVAHDSLKPVAFAVWEVKNIRKKKTVQIQLEKNRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLE1</accession>
    <name>A0A6A6QLE1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_583709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="823504at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
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        <property type="entry name" value="Haem_peroxidase_sf"/>
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        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
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        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
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        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
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    </dbReference>
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        <property type="entry name" value="An_peroxidase"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="90293" checksum="3A5C29796D82D984" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLF8</accession>
    <name>A0A6A6QLF8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_540904</name>
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    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
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    </feature>
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        <location>
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    </feature>
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            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="522" mass="58636" checksum="4E7C008148B63DD6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLJ1</accession>
    <name>A0A6A6QLJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho1 guanine nucleotide exchange factor 3</fullName>
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    </protein>
    <gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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    </feature>
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            <begin position="371"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1241"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2492989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1709" mass="188211" checksum="09F6B6DD2DD8E666" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM29</accession>
    <name>A0A6A6QM29_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_79993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="31"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="451" mass="49792" checksum="E9896CE766B648C8" modified="2020-06-17" version="1">MASMASMAYTYGHHQVYPEPPASSTCLPAPGDLPSEQYHLFIRQHPKLALLSTTGTEKNRKPVDPPPVVQLKIDQRVDPSQHYLNNPYLFMAVSLYKGDIDQDYEDKPGKSLAGSLTSSSHRLKDFDNSDCCFFVYSDISPRVPGTFRLKFTLFEFRKDAGPGGPGGPGVVVFRASIISDKFVVQSQKDFQGMEESTMLSRTFADQGVRLRLRKEPRTMIHKRNNLPFSPSSTPLAARRPSMDGYTQQGYSSTYFNDGTYSSGRHIDKRSRPNDYAQYAVHPYHYQYSPVTTRDYQFSSMSTNGLGSYNFSSGAALPQLKSESRVSTSGQSALTSDTTSQYGISPEQALNSLGQQRTPQQPVQPPVTYSEGYSLPTYRGSSSNTELSPTDNRLNTALNSGIAENFPSQPLAYRNASATHGDRGHQALTSPGALQMSDSLLVSGITYPSPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM89</accession>
    <name>A0A6A6QM89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_490360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM89"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="13"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2493628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="342" mass="38493" checksum="44982346D40657CB" modified="2020-06-17" version="1">MGVAEDLKADLPTAMTMAAFMGVAWYLCVELNIRLWFAFLRKKGLYFWACCVASWGVMTQPLFMVLVDFDQVTNPYAGLTLIYISWFMMVIPQSVVLYSRLHLVIANPNIHRYVLYMICFTATCIALPTMGLGIASQGSGDAKLLAANKVWDKVQVTVFFVQETIISVLYIIETRRVLENRATLGQTDKMVRTVMQHLILTNLLVVCLDIALLGLSYSHFFYVQSAFKPCVYGVKLRVEFSILNRLVQSVRGNNTYGSHSLPDHGASKKEGESRWRSTPRHDVRLNTYSNTSEINIVAPPSVRRSSSGAESLKLAPYGKDAILQTTRISVTQDKHEDEEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMU5</accession>
    <name>A0A6A6QMU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BU16DRAFT_96946</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMU5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2493063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="307" mass="33549" checksum="86265202048465AF" modified="2020-06-17" version="1">MATPSGPFAPQYVHGVYIPCGLLIVGCAIVKSEWLPYAFAVAALLGGWKVYSNPRKILKPDQFQQFELKEKTILSHNTAIYRFKLPRPTDILGLPIGQHISIAATLPGQPKEVVRSYTPISSDLTPGYFDLLIKSYPTGNISKHVASLMVGQTMKVRGPKGAMVYKPNMVRHFGMIAGGTGITPMLQIIRAIVRGRATGDKTEVDLLFANVNPEDILLKEDLDELVKGDSGFRVHYVLNNPPEGWKGGVGFVTADMMKEKLPAPAKDVKVLICGPPPMVSAMKKATESLGFQKAKPVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNU1</accession>
    <name>A0A6A6QNU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_79329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNU1"/>
    <dbReference type="OrthoDB" id="4120989at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="321" mass="35745" checksum="B78131393CDA3B05" modified="2020-06-17" version="1">MTLQAHSSSAPASIKLKKSLMRTSTRFHERLASMPSDPADPEGVKELVVVALGAFERYYVCWRNQVGRYRQDSYGLPESLRQWLFPPGGGSRHLQTLQIVFGRGDEFFASDKDGKLENKDTDLREKIPWADSLVEKTGRPLLRRSTTLSLVRPTSDPSLNHLGPITEAPSRYSSPTFSSSRRRPQRISCMAGALPLDRMKSSREVKPRSEDAAPKFPYVNAGVQTDPEPTESLPSLQEDSSDTSVSSPLSSRSSAAEVATPVAIASPAPNPVVMGRMLDYFNAPKYQLGDALRTTYCHQLSFPEHSLHETWRSVLDRRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ20</accession>
    <name>A0A6A6QQ20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_428590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ20"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="54" mass="6360" checksum="FB06FB22B5163D7E" modified="2020-06-17" version="1" fragment="single">SREGTPSTAIRQISLMKELKHVNIVSLYDVIHTENKLMLVFEYMDKDLKKYMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQA4</accession>
    <name>A0A6A6QQA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_466383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQA4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="111"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="482" mass="54102" checksum="23FFED394BC9D0DE" modified="2020-06-17" version="1">MEKSSKHSQSSTALNGMNSPRQGITFPPDIARGGSKSLRHPRRERSASTDHIPHVAKDDNTVGLTANILTQRAAEGVGMKARRLSTSLPNEFNVDHVDLDKEFKSSSLMPGKRGKLLGKGATAQVRIMARKEAANGEEQLVAVKEFRNRERNESEDDYIKKIKSEYCIAKSLHHPNIVETVRLCYHNGKWNHVMEYCNYGEIYSLVDRKLFASDGYYSQTDRLCLFKQLIRGVDYLHSHGIAHRDIKLENLLLNKDGHLKISDFGVAEVFSGEHPGLRAAGGECGKNMGEVRLSASGICGSMPYIAPEVLIKGRSYDPRPLDVWSCAIVYLTMTCGGCPWDGAQKDGGNYDKFEAGWTKWLENHPDGQLTEGDDGYPKCGMLFGLIGPPPIKRLLLKMLHPIPEKRIPVRDIVKLSYFKNIECCCPDSFEDQTCCIDVSQAKKGSSKMMERKKHLHRHIPPKPERRVAKALQHRFDMGEGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQM6</accession>
    <name>A0A6A6QQM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQM6"/>
    <dbReference type="OrthoDB" id="3438983at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="38232" checksum="B45A2E5BA2B55E8B" modified="2020-06-17" version="1">MPMRLVNSKITKTAPSSNQASSFRSYSAALAEPITSVQDEDLEFPAVEEADGAVQSSECNSAKLSENTKPPEINPTQMPLAVQRIFWHSSNIPRKYGSATRSANRNKELKQLTTWMDEPSSSATALGLPSSSRQVAQPQTSGLQSNFTSPTPELIRRIQRAAEAAVGSGTLLSTLASAWDLTEFHANAPKIETFKASMVINFTMKVLCDDPRAKVGDRGIVPTEQGVMLFKQRFGIILTMHENGFTVVPLYTHRGSGISHLHRSEWHKYAAIGLKGRDPPFDTYAPGPRLLLDENASFDIKGSSYARLNQRHTIDFDQKTPLDGYEAVVGCLSKESFEELKRRCAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQQ4</accession>
    <name>A0A6A6QQQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_528507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQQ4"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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</entry>
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</entry>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="297" mass="33160" checksum="D71BB1D7B472B06D" modified="2020-06-17" version="1">MAAEQRKLLEQLMGDTLLLGPGTRAPQISITDPKVCPSYLVGTCPHDLFTNTKQDFGLCPKVHNEGLKTEYEAASDEQKRQWGFDFDYMRDMQKYVDECNRRIDSAQRRLEKTPDEIRQTNALLKQINDLSKTIQNGLLEVAILGEEGQVNIAVTEFFKIRQAKQTKEDREKELKALSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRKTYEQLRKELKGKQPPHRPPPEDAAPPRGGGGYDEGGFGDRGGYGGRGFRGGGGFGGRGGFRGRGSFGGGQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRV5</accession>
    <name>A0A6A6QRV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_540139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRV5"/>
    <dbReference type="OrthoDB" id="10540336at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="17665" checksum="3D9EE158BA52C8C9" modified="2020-06-17" version="1">MFSQFAESYINHGRTRAEFIPFKRAKTGSAQYHSSAHLKLNQLLGAGSCFQPSSSARESLHCAVGMATFAGFSKGLEGSGATRVCNGDSPSQGPSWRLVGDSSSVAQDATRRGLVGRTGSATAAVSGVPRTWQAFLARGCGTAAALHRRLMRLGGQALLGPVGVPGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSA8</accession>
    <name>A0A6A6QSA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_527151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSA8"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2495275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="375" mass="40738" checksum="88DA138514F218D7" modified="2020-06-17" version="1">MPIRSDWKLQREGITVDTIGRLIGRTLLNPAITLPLLLAAKYTVKGEALATNHGRTLKNLKTLVYWGLARYVSKLLDSAVANNWTNDQYDWDKEIAVVTGGSDGIGAIVVKLLAERGIKVAVLDVQPLKYEASPSVHFFQCDLSSPSSIASTATSIRTSLGDPTILINNAGCARGKTILSTTEKDLRLTFNVNTLSHYFLAQAFLPAMIAANHGLVLTVASTAAYLTAPQMVDYAASKAAALAFHEGLSAELATVYNAKKVRTVVMCQGYTRTPLFKGFDDSDRRGAGYALEPETVAEEIVKAVLVGRSGHVMLPAASWFVVQPVRGWPLWMQYGIRKRLAKLMKGWDGRQVVQPSEGKIEDSGVLVESEGESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSL4</accession>
    <name>A0A6A6QSL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional co-activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_561428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSL4"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2495124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46767" checksum="419C83BA318B8588" modified="2020-06-17" version="1">MAGTIRPDTITVSTSTPIISSKSLPTAAPAVKPVGKPTVTAPRIDLEPLYTALKSAVGDTDWTIYKEAIRCFVIGELNQEELSRRIDPFICCDPAREHLHNQFITAIYGNTYRDPPEPGVATWVSASDKPTAVTKSATGDEGEERLKKEIMQLPRRERKRLKTLQDASPYDNFQQTMMDYHTARQIKPPDTGPASAGGYSKTNWDLEIRKRYAQPLFSETNEFPDRETIAARMVPICYEEGLANGAATGAADFLNIATEAYIKEALSNILGRVSSNGAPYVKTASYKRRLEAEEEKFARGEVVKNPGGRLPVEVESAAARPPLSMEDLKLVLLLGDGYFGQVPLIAGQITNGGHLDVEFEGREVGDEIARAPDRRERVNGVNGAAKGLTNGVGHGAGADAALDDAELTWQGGSPADQGSLNSVLDQVLSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSM6</accession>
    <name>A0A6A6QSM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_486338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSM6"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025393568" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="307" mass="33194" checksum="112CB422AF75B241" modified="2020-06-17" version="1">MRQSLVLPAVSLLSLLPTALTTTSAKRGLVYVPPENHPDDDNIWDSSTSDLTWYYNYNYAATPSLSKSKLEFVPMLWGASTADTGTPFLDAVKAQIKSGTNVSYVLGFNEPDGTSATGGSGIAADVAANAWIKQIEPLKKLGVKLGAPATTGSPDGFTWLQDFFNFCDGGCNPDIMPVHWYGNFEGMASHIGQKMAAYPNMKIWVTEYGYPNQDLETTQLFYNQSSEYFDRVANITRYSYFGGFRSSVSNVGPNVAMLTQDGKLTDIGSWYLGGAATHNKPKGAAGRVTIFAGWSVVVAAAGLWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU66</accession>
    <name>A0A6A6QU66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_572217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU66"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="245"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2495935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="344" mass="36741" checksum="024580E283B53D96" modified="2020-06-17" version="1">MSDGRKTRSSSSFHFVAGLSSGVLSAVLLQPADLLKTRVQQARTTTLLSTIRSIASSPQPIRNFWRGTLPSAIRTGCGSAIYFSSLNALRQRVAFATLVRNNANGTAVNTQAGGGGGGHSSSLPKLSNTQNLLTGAAARTWAGFILMPVTVIKVRYESSLYNYTSLFSAIRVILASEGPRGFFAGFGATAVRDAPYAGLYVLFYEQSKRRLSAFAARLQYQKAQKRSETGAVSPEVAAGLLSGRTAASINFASGVAAAGLGTAMTNPFDAIKTRLQLLPQKYGNMVQAAKLMLKEEGVGALFDGLGIRMARKAVSSALAWTLYEELIRRAEVRWKDTRDAEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUN1</accession>
    <name>A0A6A6QUN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_423042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUN1"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="307" mass="32579" checksum="1A4831DCA652354F" modified="2020-06-17" version="1" fragment="single">SSQIYDVLVVGGGPAGLAAALTGARVRANVLLVDSGEYRNAGIKHMHTVPSRDHIAPEEFRAAARAQFERYPHVQIKSARIVEAVQKETASGFPGFEIRDDKGETYAGRKLVLATGSRDVFPAIEGFAENWPSHIYQCLGCDGFEQRGTPIGILGFAGPEGAHLATMALAFDKRVTVFSNGPVSDAAPIQAGLAAVKAQGVKLDERKIRRLINNGESHEQGVSIEFEDGESVTLGFLVNKPPTVNRAQGLMEQLGVKTVPKEKGGHVEVVGMMNETSVKGCFVAGDTMTPMKQVAIAMAEGLKAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUX3</accession>
    <name>A0A6A6QUX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_618309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUX3"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF38">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="71"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="306" mass="34512" checksum="286D35F719ED2F9A" modified="2020-06-17" version="1">MKTFNNKLAISTSSLGLHPSHSLDHKIHAAASHSFEGIEIVHADLKNYTTSRKVDIEIGADLNFEGHTSPLEERLSVAAEWIKIARILGATYMQVPAQFGKDAIEDEALIVSELQQLADLASAAELVISIAYEPMSWSVCYRTWQDSLRLANLVDRSNFGICLDTFHIASKIWGNPYDPSGKYPSGDKNLANSLRDFVQDFPLEKLFYIQLADGERFDPPFSDKHPWYVEGEAAEFTWSKHARPFPLESGLGGYMPVKEMVQAWVLEKGFKGWISLESFDRRMRDKSIEPGHCAARAENSMHRLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVE3</accession>
    <name>A0A6A6QVE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_485655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVE3"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="334" mass="35574" checksum="90DEB3815C60218C" modified="2020-06-17" version="1">MPSDITVFKGSESGQLVQSITPGAPLQDGQVLVKIHHASLCGTDLHYLHSDQVIGHEGAGVVEELGPGVKHLRIGARVGFGWHHDSCGACPECLRGDGPHCRVDPHAFGDHELDQGGFATHAVWQADFLHPIPDALSTADAAPLMCAGMTVYTPLIRNVKPGQRVGVVGIGALGHLAIQFAAAMGAEVVAFSGTDSKKSEAIKFGAKEFVATKGKKDLAAELKGGLLNHLVVTTSAVPDWNQYIGLMAPYGSLYPLTISFGNLEIPIIPFVVKSLNFVGSTVGSRVEFKQMLDFAVLHDIRPVIEKFPLTLDGLAEAKSKMEKGELRYKAVMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVG9</accession>
    <name>A0A6A6QVG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_420552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVG9"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="113" mass="11816" checksum="BF3E2BF1BF22A880" modified="2020-06-17" version="1" fragment="single">LRSTPIANIGSVARDHLANERTFLAWTRTGLGFVALGVALAKLDALEALSPMLKHDHGDLKIQATALVASGTGCLTYGTTRYFASLRLLQRGLFRPNIAGIALVAVTSAAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWY0</accession>
    <name>A0A6A6QWY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_344572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWY0"/>
    <dbReference type="OrthoDB" id="3941110at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025526898" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="60780" checksum="7902273510364B3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX57</accession>
    <name>A0A6A6QX57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_616838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX57"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2496732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="263" mass="29074" checksum="0AC7A40B212D6DDA" modified="2020-06-17" version="1">MSGSGAREAVFPTRQSLGLMKSKLKGAQTGHDLLKRKSEALTKRFREITRRIDEAKRKMGRVMSIAAFSLAEVTYAVGGDIGYQIQESAKSAKFRVRTKQENVSGVFLPQFESFAVEGSNDFGLTGLGKGGQQVQRCRETYARAVETLVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPRTENTIKYINSELDELDREEFYRLKKVSGKKQRDQAAGEKERAVALAAAEGKENVDAPSKAANDAADSEDLLGDKDNEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX98</accession>
    <name>A0A6A6QX98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_340064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX98"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44992" checksum="58053E95EC1A47CC" modified="2020-06-17" version="1">MCCNRERGTLANSTTKNLCLTESRQSIALNTTLTLKLPVYTLFHLIRSAGDAMRRSSGLGRFSWKATNLRIGIYYKGISIFQLKLYQVFESQHGTWTESIDEIDRVLQIRPTDILDDRKRNELMFDSSLKVSEQYFAILQILRIMREWICDALKDLERQKEIWQSDRGYRLSRKLDESIIESNWEVLVSLQQGFEKILLDRIDRKTEEVKSLRDGLFNATSVLEAQRGTEINQYLFVFTVTTIFYLPVSFVATLFGMHLFDSESLHRTRTSFYVSTVLISVVTYVLSGFAAWWVGNSERRQRLKRYWKSLRAESASETNSETKQASTGKESTPVLAEEKSKSKTLWSGLRSRKHKDNDEEFQLPDLGELNVSTRESHSSSPDLARPTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXQ4</accession>
    <name>A0A6A6QXQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_526040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="267"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2496989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1486" mass="165306" checksum="4605021717C69AA2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY58</accession>
    <name>A0A6A6QY58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_549152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY58"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
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        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="56"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="9">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
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        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="911" mass="101325" checksum="A22F71FDDADA5C1B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYE3</accession>
    <name>A0A6A6QYE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_458562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYE3"/>
    <dbReference type="OrthoDB" id="3869073at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="77" mass="9412" checksum="AD2D8826EB7A63B3" modified="2020-06-17" version="1">MCTEWHHRFRRCGHTRFFRWEYCKMVKKHERSPEKGTACPKYSAKYRDNQEGYNCFVCLQERAQRVTRHARHDSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZH3</accession>
    <name>A0A6A6QZH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_525295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZH3"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="34525" checksum="EC17799174C7D7B3" modified="2020-06-17" version="1" fragment="single">MCLSCSGVHRGLGVHISFVRSITMDAFKPAELARMAAGGNKPFQDFFNAHATNKADGRTFDASSISERYDSYAGDEWKERLTAKVEGREYDAANLPKRVKKDKEPAAAPPLSGRASAAGSRSQTPLSRARPGDGSGMLPARSGSPALGTSSLGASKKVQNEAFFARKGQENDGRRADLPPSQGGKYAGFGSQPAGWEKEDESAPPAIDDFQKDPIAALTKGFGWLGATVGKGAKTGYEGWVKPGVQKLSEADLAAQARQTAAMLGQGIQQGTSAAATSISRFVEGEDDRSTATRPGRRAPEKKDFWDEFGQAPAGPPPDKRDFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZR4</accession>
    <name>A0A6A6QZR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine kinase</fullName>
            <ecNumber evidence="8">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_617130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
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        <text evidence="3 8">Belongs to the uridine kinase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR10285">
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="445" mass="49728" checksum="A2A76DBDDD27AC01" modified="2020-06-17" version="1">MAPTDRCDYSPPWGNASIIGVAGSSGSGKTSLALAIVAAMNLPWVVILSMDSFYKVLTPEQSAAAFRSEFDFDSPDAIDFDKLVDVLRELKKGKVAEVPIYSFEKHARLDKTISIYSPHVLILEGIFALHDERVLDLLDLKIFAEADGDLCLSRRLLRDIRERGRDIEGCIKQWFDFVKPNFHRYVGPQRELADLIIPRGIENKVAIGMVSDRVEKILAHKSKLHQVELRRLGEVASDSPLLPNAIVIPQTNQVLGMNTLLIDPATSKEDYIFYFDRMVTLLVEKAIDFLHFQPKQIKTPQEYVYMGLKKSGEVSAVVILRGGSAFETGLRRSIPDCRTGRVLIQTDDKTGEPELHYRALPANLSKDGLVLLLDPQMSSGASALMAVRVLVDHGVPEERIVFVTYMAGKIGVNRLLSVFPEIKVVIGRMGDDMESRWVETRYLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZU2</accession>
    <name>A0A6A6QZU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_616522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZU2"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="133" mass="15720" checksum="BBF5EA653462E40A" modified="2020-06-17" version="1">MGSFDKEQLRRYEERYEEQERSRRKAYEEEARKVAHRAEVKQRAEREAQQVEDARTDRLHWTGAAWEDRRLSQKPDESYATEGNISPVSHNPWDAAYETLNRQRQAKNVTDAMKRLGRTLAGKEKPPPQPEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1B3</accession>
    <name>A0A6A6R1B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_558551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5342093at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6594"/>
    </dbReference>
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        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="15"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="283" mass="31967" checksum="8C0A89D8AB89AB22" modified="2020-06-17" version="1">MSRTPLLLQNAPPGYPRLAAFISMDKEHAIFRKFQMLNCRNLIYLQSEVTSLETQLLRVDETLEKSSVDDLRSWPAFGSDPERLRLVERISNALEKYNNALIQYQQVLHMQSPTPSSISGLQRWLQETDPIIDNASDYLEKRIPEGDIKHRKVYPETMDLVSLDQNVDSKLGKVLRSSLLKFLIFRDIIYLKDGKNFIIFFPGKKVDKIVAAIAVFFAVILTVAAVVALSYEKRAPVRLGLIGMFTFLVASMMALSGARKSEVMMGTIGYVAILVVFVSSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1I3</accession>
    <name>A0A6A6R1I3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_505116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="27120" checksum="DFB28B3C14B26212" modified="2020-06-17" version="1">MSSNTLHNALLRPAILHILRAAGFHAAKPSVLDILTDITSRYILLLASRTAENAVANHNTPEPDITDVRMALQDCGLLVPSLTPGEEAWKEMLRKPLEQYPERNGLREKERIKRDEEDTQDVKAFLDWIEGEQNREIQRIAGLGAPPAPAITTTADLDAKEMEDYLTSLMKKHSKTGVESRYQGTILGQPSEIKPVKIEGGTIESIGEWRLRMRQRAAKPDSNTDTNSKAVDSVETNGHMMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R233</accession>
    <name>A0A6A6R233_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_548221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R233"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="544" mass="58101" checksum="CC6542F720947738" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2E2</accession>
    <name>A0A6A6R2E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_455374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2E2"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2498938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="137" mass="16260" checksum="3C35814DB4D8D70F" modified="2020-06-17" version="1">MDIDFTRRNKKPRPLSEAEKEKLDEFIEAIHYSARYSDPEYEYRHVQLPKQMLKAIPKDYFDGQRGTLKLLWEEEWRALGITQSLGWEHYEVHEPEPHILLFKYVYIPILPYPSILSSSGCPPRIRTQDTDSIPDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2I2</accession>
    <name>A0A6A6R2I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_536590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="293" mass="30556" checksum="2C7DA28A698D3608" modified="2020-06-17" version="1">MRLPTVALLLLVGALPSIRLITDATPVPVQVASLQAGVCQGLECEDLRRNLPRAPPAPKAPEEGTPGGRPSDDPNAAPATFGGGEGGGGSPFGGVNERPPGSPEPPGAPEAAPAPAESLDLSLPQAVGIPHPPSAFWKEFSALAADLGPHGQSPVPRDKAVMYSGGMEVHASNWVVGADDGYVLLEDVLRNDWKSPSRAPENKDETLLLLDIQSAAFAAAASGEVKVFLPEEGLTSETVFSRVVWPQMVAPESGVTKITWVDDDDGTDVGDIWAKEQGPVPFELNKHPADMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5597238at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="17417" checksum="4A940569AD11D58D" modified="2020-06-17" version="1">MKYSAIILSTLIACAFARPNASATVTAAPSVVSGLSPAQTCIALCKAGDVDCEAACVGAAHPNSSQVVDTTQCAMKCDQGDGTPAATQKYSACVQACIASHFPTSQTIADAAGTAVASASVTGSQASEATGKSTTGTKATGSATGTVTGAAASSSTGAANAHAQMGAGAASFAGLLMAIFAL</sequence>
</entry>
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    <name>A0A6A6R3G1_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3932653at2759"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="367"/>
            <end position="501"/>
        </location>
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        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="501" mass="54505" checksum="BD1354B634FE534F" modified="2020-06-17" version="1">MPPWGRPPGGQGRRRGDWERPAEGVYRFQELDSDEDGLHGVALDPSMQKGRPPSFNPDELYFNDMDPRAWEQMVTERDRLAYGDVYDHSEDEDGYFEEGGGAIVHLAPLDQEEVLFQRVLDKIRRARGTGKPNVALTQEELEAYEARILRNQQVPAPAARPAAKIKNTSSTPTSASSSTRSKNAQRRTSIFSSPKPVKNKSSGSGKKRVSSGQLDSTPVPAPAPGFMIPGPDGQPMYAPITYNPRGPQSRSARSISSHSRPGSRSPSLSSRNGNHPSTPPREAPGAFPSDSPQHYENVTPPVQKSRQSSYPPRQNSFLEDADWIQSARSRSDPSALHQLPLQPSPQLVPFPVSPYQHYNADPYQYMPQSAPSMTPSSVQPQSQPQVASQYARDRRLGAAASDNYINMPRRVPVPNQRASMQSSYSDPALGYKASGLRDELSDDDDDDGQHGVLVDVVQETGSGPGYNVNVTKPTGPGSGSGGGNSGGGSGGGERRRRGRRK</sequence>
</entry>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3I3"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="78"/>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2499056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="177" mass="19116" checksum="6EB6540C04CF45EC" modified="2020-06-17" version="1">MSHAYKKPTQSFPGFGGTRSDKQQARRPTLDWTSSPQAIEAQATMAGPAKKRARVEQSSSSSSDDQKSSRNGGCEGSPQRSSLTTLQRASPQSIPRVDDNRDTQGGVSGRRPLPIEYLNLRNLSDALGMMGWAAASYCDEDGSENVLTGVNSNPLAARRQSFSWLNNSQLPGKGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R439</accession>
    <name>A0A6A6R439_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R439"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="110" mass="12591" checksum="74D586DEF3217F91" modified="2020-06-17" version="1">MRALQLSSYRQPLVFTKALRAPRPHWPLTALSFKLPLLAHIPILSTHNLPRLLPASIELKHLLFALEPPEPLVSSQPKLPNSRSLWFFLLEEESRGPRHTSLGFESFRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R447</accession>
    <name>A0A6A6R447_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_438514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R447"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="205" mass="23431" checksum="BC77C55801334D21" modified="2020-06-17" version="1" fragment="single">KATSTAATHTECVACLETKPNFDMLHLNCQPTPHAYCRDCILDLFESSLTDTSLFPPRCCRIPISLVDCEPFFTRDFVDRFIEKRIELNTSNPTYCSSVACGQFIRPEFYSGNRDIATCPKCQHETCRVCKTHGHQGLCPEDPTTQPFMDTAHRNMWMQCRSCKHMVELESGCYHMTCRCGAQFCYLCGSKWKTCSCPQFEERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4T5</accession>
    <name>A0A6A6R4T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_558518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4T5"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="44"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="19163" checksum="F51FDD951D3D7382" modified="2020-06-17" version="1">MATEDAPARPRPTTAPIFRAPKQVSRPKEVQTADEELGTELRLGEFENVAALSVSEARTVISAVHNARRKKDPATNPLGGDKIHNDSEAIIKFVEYMDMFSRFKQTDVIHALSNLLSTRTEFVPVERAQLGSLLCDSADEAKTLIPSIATKISDNDLQELLDEMQKLRRFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6H4</accession>
    <name>A0A6A6R6H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_522904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6H4"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="232" mass="25904" checksum="BBBBC2ACD99B485D" modified="2020-06-17" version="1">MLTSPSAKRRLQTHSHKPYDPYEPANMDFAPYQDASPETHRAFSPPPPGARSPSGVRSPTYSPRASFDRTRNIGTAAVASPSTTSPQAGYFGNQEPEREPWVGNGGGGGFGGRREDVDMFETSLQRWGLRMDYEACLAYLLLPPAGGVLLLVLEHRSDYVRFHAWQSSLLFAFIFVVHIIFSWTSIISWLLFACDVALIAYLMFRAYKDAETLDRFEVPFFGPLASSILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6I1</accession>
    <name>A0A6A6R6I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6I1"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="34612" checksum="A482CC1CD3690E4F" modified="2020-06-17" version="1">MEEQPVRASQLGEITYACPTIKDYTLDDNLPVLMAMPNDGQARKQRAVDLGVLDVLPLELLQALLCQLDLRTLTDFGYVNRRATEVVGSIPQYKAAATNAPSLLRGILAIESGPWITCEALYEKLCTAECEQCGDFGSYLYIFTCKRVCFRCLSLDDRFRPLLRSHAIQKFGINDQILDTLPYMRSLPGTYSPHHTKSPKILALVDPESAYNAGIALHGSASAMEQYTSRHPRQPHHSSLNALRFVAIIHTPWLDRASQELHWGFHCIGCKNNGTDGPLNWRRKFSAASFNEHLKQHGNIRDGKHHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6L2</accession>
    <name>A0A6A6R6L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_247175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1324" mass="149496" checksum="CEC04A2C52BE5B73" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7G1</accession>
    <name>A0A6A6R7G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_556789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7G1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06228">
        <property type="entry name" value="M14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000155">
        <property type="entry name" value="Zn-dependent exopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025397250" evidence="8">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="124"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2500312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="478" mass="51909" checksum="3BEC2FE589BD3B29" modified="2020-06-17" version="1">MRYFLVAYMILPITVVLADLLPVQFKAPTAAHFRDIVRNDTFDFGCRPIAHPTDDGQFTLHALLTEEQIAHVTKEYASMPELSVHRQLVKRAATAPIGTGDRFKSGTVAPIGLGTKASGTTISSIMNVAEISSAVLGLVNTYSVTSITLPYKTFNGATQSAAYVGAGSDKSKYHLYLSAGVHARERGGPDQLIYWISDLLAANSSGSGLSYGKKTYTNAQVKSVLSAGIVFFPLVNPDGVTYDQSSGSLWRKNRNTKSGSSGSSVGVDINRNFDFLWNFRKYFDSSESPASTSPSSETFYGTAAASESETKNMVSVYDSFPKIRWFMDIHSAAGDLLYSWGDDDDQSTTTTMNFLNAAYDGKRGVVDDSVYKEYIPSTDATNVKNVAAKTIAAMKAVGGRSYTTMQAVGLYPTSGASDDYAFSRYWAKSGVNKVYGYTMEFGYSTNFYPTLTEFNENILDTNAGFMDWALAAISVGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8L8</accession>
    <name>A0A6A6R8L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_578124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8L8"/>
    <dbReference type="OrthoDB" id="5213630at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="425" mass="48531" checksum="87A6049D966916FC" modified="2020-06-17" version="1">MATSRSPSQSCEDTVAFQDQDSLEGLQDELVEVHPYSNPAGPTLMDGIEVASQPETVGSRKVAAEIAPDTLPVPPHGGSEFEPEVQSSPCASEVASYDELQSELTKERGTRVNAENELRKMETELKDIRQRWKLTARELGIIQRKGQGSGFYQVTDDYLIGLITRLRYNIQNISIQYFSERLGRASRPPKNGVLYAFMRSTTPGSDDFLEYLTHPALRPKVIEAFFWRVLVSRLFYNFKWAGRTFLSMWELYRVLEPSHHANTDWKACPNPEAEKKYHIWRSNTVALLLDSMDEKLSHKADETLPRWKARFFDQVGVMISSYRASHVRDYREEFMRIIDEALELDKEISRQVTGIQFLFQAIDSNPDFDCSTMEREKGVKVSGNKQKVLLVTSPAVVKRGRSTGEGFNEATLLLRSELLCEDRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8Q0</accession>
    <name>A0A6A6R8Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_547158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8Q0"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="372" mass="42342" checksum="C4F60F5876DE3131" modified="2020-06-17" version="1">MPSELEDLVEFLHHGNTQIRQVAVEHLVGYSATHTTLFKKDQLLPVRDLKLLVKDYAPIAKNVMTILINISHDQEVLECLAKDDAFLELLLGRITSAKEPNANEIAMLLANMAKSDDMQRVLELQRDIPNELSTSKWAMDQLLDCFVKGAEGRYNKHADYDYLSYFFADLAKFPKGRAYLTTPQPHDANIIPLTKLIVFTEHASTIRRRGVASAIKNCAFDIHVHDRLLSDAPTTGVNLLPYILLPIMGGEEYSDEDTEGMLDDLQLLPPDKEREKEADIIKTHIETLTLLTTTRGGREVLRRIKVYPILRETHLHVDDEEVREACDRLVQVIMRDEEGEGEEEKKGDKGRMIAMEAEDEDEDEDEQIVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8W8</accession>
    <name>A0A6A6R8W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_546402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8W8"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="225" mass="25150" checksum="10CD5275FBD394ED" modified="2020-06-17" version="1">MGGKIECYLDVVSPYSYYALLYLEKNRETLKSHDVDIDIIPVFLGGINVGSGNKPPWTLPAKANYSNYDSARAKKYFGVPDIKTPSFFPILSLPPQRALTYIRAHHASLLIPTFLTLFSAMWLDGHDISKPDLLAQALSAHFSPEETKAILEGANQPHYKQELSAKTQEALDRGAFGCPWFWVTNTAGVGEPFFGSDRFHFIWEYLGLPWKAVELLPSAQAKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R953</accession>
    <name>A0A6A6R953_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_522266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R953"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="232"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2501278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="472" mass="53582" checksum="9E7CB753B2C1A4FB" modified="2020-06-17" version="1">MATTVEQAPYFLDRKEKNLLIVKDPPKFDLESYIANYEGRTRLKRLEHIAMYSSYLAVDALRMAITEAKQGADENLYLSLTELLQSISREDPLATPDVEWAERTFKANKLKQEQLEGELKAYKNNLIKESIRMGNEDLGHFYYQIGDLGNAFKSYFRMREHCTSAKHLTDMTMRLTFVAIAQRNWLGAQSHATKVDAQVAKNEERGKLEPVINACMGLTHMCGNNFRDAARVFLNVSPSFITSEPVAAINFHKEVLTGNDVAVYGGLCALASMDRTELQERVLSDTDFRQFLELEPHIRRAISAFCSSKYSACLQILEEYRADYLLDIYLGPVVTDIYHRIRTKSIVQYFKPFSCVSLDEMAKKFQVKDEGYPIEDELTSMITGGILNARIDLVEGLLISPAKNPRHVVHSDALKMAQNYDHTLRLRLTRLNMQNAGMEVRAPKVDMEKNMDRGEGFGGTLRRLGQGLGGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9F4</accession>
    <name>A0A6A6R9F4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_437218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9F4"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17752" checksum="415C0CD41CDC0B4C" modified="2020-06-17" version="1" fragment="single">IKVLVGPEEATFHIHEGIIRSSSKFIDNAMKPGSTEFEKGGLRLADDDPESFTLYQEWLYSRQIHLEREEPIMKYLPACKAYCLGEKLMDNDFKNAVVDTIIRTTTETTVNESCFFPSVDSICVSYERTPRGSPLRQLIVDFYAYCGDEREYASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9S9</accession>
    <name>A0A6A6R9S9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_477344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9S9"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="9">
        <location>
            <begin position="135"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="10">
        <location>
            <begin position="300"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCC8"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="14090" checksum="87CBA71CA0E79789" modified="2020-06-17" version="1">MGDKQKKLQELSDDYQKIQGELSSAIDARQKLESQQQENAGVQQEFAKLDDEANIYKQIGPVLLKQDKTEAVMAVDGRLEFIDKEIKRFEKQISDIQQRAEKLKAEIIQIQSQAQQAQQTAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCE9</accession>
    <name>A0A6A6RCE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_533837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCE9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053832">
        <property type="entry name" value="DUF6924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21962">
        <property type="entry name" value="DUF6924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6924" evidence="1">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="272" mass="30790" checksum="09ABADDDA04AD5E6" modified="2020-06-17" version="1">MPVDVDAVLGALKTGPPYLKIEWDHFRLAANFDSHIGKSVVKIVDYHRNDPNSGGQYFIIIDDPKWEPKSDVFVVTLDEEGAPDVLRLPIGEASSACTNLDIANMKWNDWFNWDKNERFVRQGYKHFPELPAGVFNLANGDGAEDGDEEAFKDIMKTINAGINKRRSEDHDPQIARYIDKDTLGSDEDADVLNQTWPSVLIIVDQPALDTKNVLAIHVDPNTWARLDECRLAAEVAGEYLRWMGMGFCKWRQWDVIMGPKLEEAMEELSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCK8</accession>
    <name>A0A6A6RCK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_532516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCK8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="168" mass="19058" checksum="3C1D9BAA2C03B2E0" modified="2020-06-17" version="1">MGAVLSRHRRTAETAAWLALGAFGIFPVLLLLLRPLLLPARPAAAPAAEAEEEEEEDEEEENDDDDDRPAPVPAPAWVMWQEELERRREREEEERERERDRQRWRARGGMWRGWERRGAGAEEGGWRQRVGPRPQGERWGELEALLGVAHVEMGLGEGVVPGEGPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCV9</accession>
    <name>A0A6A6RCV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_500289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCV9"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="319" mass="35579" checksum="C99C9F50B4DD9501" modified="2020-06-17" version="1">MTKSKSYLEIVKNCDNFPYDQVAAFPFQEGEKEAWYQFLLPNDSRPHGYILPWVVKAMPWTSDFIISHDKPRTVQLADSSNGAHTAKTCNSALEKVVSNVIKAQTFKGFNDPSLEPFRIAGARDSIYVARSAASLFGITVRGIHMVVYTRTPDGMKIWVPRRAPTLFSFPNLLDSAVGGGIRADESPFEAMTHEAEEEASLTGNFLTENVRSCGALTYMSATDAPNGYEIGLMIPEVAYLYELEVPGDTILKPNDNEVGKYNLWDTTKVAEELKADQFKPSSAAVMVDFFIRHGIITSENDKDYLRIINHLHRSLPIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD05</accession>
    <name>A0A6A6RD05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_522305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD05"/>
    <dbReference type="OrthoDB" id="2849579at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="40213" checksum="E16287F7B9BE3469" modified="2020-06-17" version="1">MSPPHQPPPTPPHMEFPSESNQRPILTRRHSMPAHTGTRASRYQWSNSPLRSGRPHFNNFRKAVWDCVENGLSYHRLLMKAEETKPELRTNEQLHLLAVQYQVADALEQAKADMAMSDSSILSADTRRFGLHTLWMDARVLDMLTKFAFVYANDGQDAVALAYVIRKLDIGRHTAHLIEQSDITAELLVAQLNEIDQAARAANGGDVVLENVGPDPEVEKLGELWVVPKPSEDDPSPITDCCFCLQPFSEKEDPAFKLSSCGHCVGKSCMQKWLCSVSNMSHTCPQCREVLLEPRKHRPVPHSNEDAQTRQRQLEIWPFYMLLMEVIRDVFALASRAWPPEHTYVRQLAEMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDG5</accession>
    <name>A0A6A6RDG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_200948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDG5"/>
    <dbReference type="OrthoDB" id="4508658at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="292" mass="29481" checksum="87096BEB0B9A6A92" modified="2020-06-17" version="1">MSGSKLPQALEQPGLEYYPGHHAAYPQPQYLAPPTYAATKEGESGGLGDRTSNKTTILGLRRTTFWLLAVLALVVIAAAVGGGVGGSLAAKNAKSNSDKVVIPSPSSSGTINSASTATSSSSFSSTINSASTATTAALSSSSLSPSTSSTIGSATTATAAPSPIAGTACTSSDTYCGWYLGDDLGWSDYTSTALYYCNAGGLSVNLLSECVGSQCEGPTAHCGTTANAPPSPVAGTACRSSFTYCGWYLGNDLGWSNYVSEALYYCNADGVSVSLLSECVNSQCEGPVAHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDK3</accession>
    <name>A0A6A6RDK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_477253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDK3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="50526" checksum="3719D3ABBD10F1CE" modified="2020-06-17" version="1">MPLLVLGFFALQFDRGNIGNALTDHFLKDVGITQNQFNVGQQLLSVGIVLLEIPSNIILYRVGPRAWITGQIFCWGLVATFQAFQKGLGAFLVTRLLLGFCESGFIPASLYTITTWYKRDETSARFGAFFIGNFAAQATSGLIAYGVLHMRGVCNLAGWQWLFIIEGLFTITVSFILMAFLPKNPFDPVPFTRIQYFNEREKDIIRRRVFLDDPTKEKKSKNVTRAELLGTLGDWKMYPHVLMTIAGLAPSNTMTSYAPTLVNSFGYARLKSNAITSIGMWILTVLAVLWGVMADRFHRRGPLVFAGIVPWAAFAIGSVIGSYHPKQKKARLATLLLGIGFSNVWHPCNASWVALNAKTPGERSIRMAMMIMSANAGGIIGSQLFQSSDAPLYHTGWAAIAGIICFGVLMAIVCNIQYWFLNRRIDKGLATGRVTGEVAEEVAHGAPVTEKFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDZ1</accession>
    <name>A0A6A6RDZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_447748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDZ1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38205" checksum="0F8DCE5EC59C9800" modified="2020-06-17" version="1">MGHWQERIVFVRDFAFNSPRFRMATNIGDAPATTFAEYVNEPLSTHADVPKMDAPEPESSAESGSESESDALPDGPSQPYSEPNPLMPRPILAHRIHSHRLHVQAKAKSQRARLLSGPLVDIYVGPSKRHWALHRNLLCHHSEQLAAELLPSNDTKKKTPDKLELLEDDPSGFELLVKWLYQGKLDDVSDMADPNRMYDYAVCCHKLYLLCERFDMPQLKNIAMDQYRKGLSEAELVPDADEINEIYRKSSPGSPFRRLMTKIAARQIMDPASEKDAESYRACFDGAPDFAVDMVNAIRSGTGGMLFEDPTEARDDCTYHDHDAGPNCHIKGKGRAKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REJ1</accession>
    <name>A0A6A6REJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_28998</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REJ1"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="510"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="260"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2503099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1104" mass="121061" checksum="79F8C40246923BDD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REP5</accession>
    <name>A0A6A6REP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="14691" checksum="1CFE015C325E1558" modified="2020-06-17" version="1">MSVSTITTTATVTQTVTGERPSGGYPNPAFPIVALICLSLLFIFMTVFLILMIYTTYRDGTCQKCKNQSNRDPGGRRAWSSHPFAAATTAGVRSLQSMESLHSAASLSTFGSSFDQTNTGTPFALVVRKVSTGLVGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF55</accession>
    <name>A0A6A6RF55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_6768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF55"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="71"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="413"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="521"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2502380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="631" mass="72275" checksum="094BBB0C8A93157E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFL8</accession>
    <name>A0A6A6RFL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3595619at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PROSITE" id="PS51257">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="574" mass="62167" checksum="EF72835A1A0340B7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFN9</accession>
    <name>A0A6A6RFN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_474852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2502553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025525688" evidence="10">
        <location>
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            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="16"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="541" mass="60330" checksum="185BCA8CB9988AA1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFR1</accession>
    <name>A0A6A6RFR1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase ABA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abscisic acid biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cytochrome P450 monooxygenase aba1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_449304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
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        </cofactor>
    </comment>
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        <text evidence="1">Hormone biosynthesis.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2503192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="527" mass="58915" checksum="E62164E4FECB40A1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RFX8_9PEZI</name>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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    <sequence length="274" mass="30255" checksum="370557B6B775630E" modified="2020-06-17" version="1">MSLPPPKALLFDIGGVCVVSPFQAILDYELANNIPPGWVNFSIQRAAPSGAWQRLERGEAVLDAAFFATFKAELEQPALWDEFWAQQSKLGKVSGAKPPTPTVAAHDMFWEMMRVSRRPDPWMYPALKKLSASGKFVMGALSNTVAFPEGIVDDKGVVFVNELVHDEGEFEGDSRAIRDRFDVFVSSAHVGLRKPDARIYKLARRELDGESRRRGLGPVEMGDVLFLDDIGSNLKGAKAVGMRTLRVVLGETEKAVKELEGLTGVRLVEERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q9A5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_224982</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6Q9D4_9PEZI</name>
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    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PANTHER" id="PTHR47643">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488701.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="668" mass="73960" checksum="3D005F73587BC005" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QA77_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
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                <person name="Henrissat B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="186" mass="17735" checksum="43F504AA18C33EC2" modified="2020-06-17" version="1">MFGGPFGGGMGGMGGGIGGPGGGMGGGRRGGGRRRGPRQPDPYGSGDSDGDGMGGMGMGGGRRRRPGGRDPRMFGGMGGMGGMGGMESMGGRRRPMGGSMGGMGGMPGMDGMPGMGGMGGMAGMGGMGGMRGGMRSMGGMMGGMGGMGGMGGMPSMGGRRRRLGGMGGFGGGEAPCADPNCPCPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAK9</accession>
    <name>A0A6A6QAK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_472132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAK9"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="147"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="435" mass="47957" checksum="BD39E9F88AA1585E" modified="2020-06-17" version="1">MSSNKRSTLSYLPDVLMVVAAPIMAYFIVRGIISKLDPDAQEREKAKEKASAASQKLSSILENKAHYDSDDEDYDSSQRRPRKEDLVLTPYEQTIAMEVVAPEEIPVTFEVTDIGGLDSIIEELKESVIYPLTMPHLYAHSSSLLSAPSGVLLYGPPGCGKTMLAKALAHESGACFINLHISTLTEKWYGDSNKLVNAVFSLARKLQPSIVFIDEIDAVLGQRRSGEHEASGMVKAEFMTHWDGLSSSSRPGSTTPQRICILGATNRIQDIDDAILRRMPKKFPVALPSASQRANIFTLILRGTKIDAASFDLDYLVRVSAGMSGSDIKEACRDAAMGPVREYIRRKKAEGAGGLRGGVRASEVRGLRTDDFFGRWREKGREPGEREVEDPEEVLPTTYRKARTATTDESEASSSVEEDFRDSAYVQAEEAEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAX5</accession>
    <name>A0A6A6QAX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_598083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAX5"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="506" mass="55526" checksum="3112F7734A4B307C" modified="2020-06-17" version="1">MSNPTNPTPPATVKNSQPESTTTPPERFGFPKQGSRSLSYWLQSVQGDPLLNHRTTPELPKSADIVVIGSGLSGTLITKHCLATWPDKTVVVLEAREFCSGATGRNAGHCKPDQWRGFARYEEAFGTQHALKILQNEQQTWSDLVQYIRENKVACDLWVGDTLDVPVSQEAANFSRHSFERYEAAGGRVDHIQVTHDPAEAARVRNFTELFVLRLTGAQRSRIKDAQACYSWPASTLHPWKLAAHVMRDNVSKGANLQTHTPALCVKESPDTPGKWIVECERGIIECSKVIHATNAYSAALEPSLRGVIRPCPHMCNRVEPPSTFSAQRGLQNSYGVLLSNEALFSINPRCTADGVVLFGGSNPGQKQFEEWIERHPDRCVDDSLVDFGCITDAVQTFAESQLVGWRDASTDPEVLYGKSWSGIIGMSADGVPFVGQLPGLPGQWICAGHQGHGMARIFTAAPGLVKLMNGGSWASTQLPDVYEITASRMKGLRQRLAKDMAVPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB94</accession>
    <name>A0A6A6QB94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB94"/>
    <dbReference type="OrthoDB" id="3648773at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGB3"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="46591" checksum="B15BB299C6BD1168" modified="2020-06-17" version="1">MSGKRPPTLAAPGERDAKRPSRVDKIHLLHQQIAGLEAELATTLRKKEEARKGNYHEYLEGQLVNDTQRMFVSSNQTSANSISPFRFKDLPRELRDEVYRHIIHASHSTLFAERPSDPKKPGAIGGHPYHQAILLVDRQLKEEVVEFMKMYGQLTFQFGCRNEAICTKCDNCQTNHLLDGLWWVEYTLGKDVQLMIQRLCNRYHHVYIELAVNRQLAPEKTKRLHCDLRWFLGQYGHTTRYSTDFTTGGQCRTIIDLGSLFRTQADPMYLLLADVHLDGRARSVESPPPFVHLIGHDLQNLKSFALEVRKLKLRPGCFSIICDIPKDEVSESSEVSQRFNVLKTGCKKNGIELRVRSDKEVTRNNLWRGPAFRPPALGRVFVRRVINHGGGSEQIRFRRVERDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGN1</accession>
    <name>A0A6A6QGN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGN1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="452" mass="52053" checksum="FEE7516BBF4DDCC2" modified="2020-06-17" version="1">MAPTRRSKAASKKATSSKKAPPGRVLKTERVTRSQARIPQQAQKLQQALQQEQALLQQRALLLERNLLQQQGFQQDQDFLQRQGLQHQDALDQHSEAKAARTPTTFFSLPRELRDMVYNEVLEDVQFVRPWDAIGCGWKKITPATLLMNKQAHDETKEAQKWRTISCEWEIEREIQPAPEPKDEDADMDSDEEPDHEQSRPHRGGLCLPGYTVMDHQLTPTERHALTHLAKMNIVVDPRGPFGETRSKLFTSVKTCVEVWTKASAEYQWDGRKRQFTLELNDCLGYINKTRRVQLWAQPRINRTFEAEEDLQKLRGVVEIMKTDTRTQWKIVVPEIHHDWHQLYEWDDFEAANASTDNFKLEVIEEGCHECEQAEGRRDWFAESVKAQVRHMRNQTQQAEGDGDEYEQDEDGSASGDHSESEDDDENQDGGSDASEDSSESEDVECTWLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGX1</accession>
    <name>A0A6A6QGX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_584880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGX1"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000145">
        <property type="entry name" value="Pigment biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="45289" checksum="CD79BD01C87B077F" modified="2020-06-17" version="1">MPTNWILGDLFTKDYGHAGSIAKLWEQRWLFPCKRGVYPFHDGVFEDFEGIFNHLISENINDPYSDEYTSAFLPTADALVEKAEAAEKSDRPLAIQFYKRANAVYRLARFPYISGDLKKQVFETQKRAYLRGASLWDIPVTEKVIKHNHASTGDGDAIPVYLRIPPTASKTSPCPVVLLITGLDGHRPDNTERTEEHLKRGWATVICDIPGTTVDCPASKTDPLAPDRLFTSILEWIAAQEQLDSKKVLAWGLSAGGYYAIRLAHTHASSLAGSVGHGAGTHHYIGREWLEQIGKHEYPFGLERAYCEKYGYGSFEEMKEKCQKTFSLVSGEGEGVAVVAKELPSCRLLLVNGVLDGCMPIEDSMLLMEYGTPKEGRFVQGRAHMGYPEANSYVYPWMESILGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH35</accession>
    <name>A0A6A6QH35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_584701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH35"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="238" mass="25429" checksum="DBA8A4F8D76BDC96" modified="2020-06-17" version="1">MQLPHLDGELLIPASCTPAGPARQLGMAAGRFPLPPGPVDARGGAHCALVSRGRRLEYFCWADGPDDYPQPLNSSLPDAPGTHTMPLSRGPHNSSSSSPTASNARTTNRPPTIASCNNFHSCNQHGHLASPSPDTSPGSFADVRSIKLSRSRLLQALFADSRSRNSVGRTSTGAQTSRSLSSPDKLPESFKNCHLDRPVIRLFSNLLAAYQTQQSRASNLPSFEHLQLPPTAAKETTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH57</accession>
    <name>A0A6A6QH57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_530021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    </evidence>
    <sequence length="1151" mass="125630" checksum="2BF307A5F96A1EFA" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ75</accession>
    <name>A0A6A6QJ75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoribonuclease YSH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_529754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2492425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ75"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="9">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="10">
        <location>
            <begin position="491"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2492425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="785" mass="87189" checksum="B778CF523B4833A7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK53</accession>
    <name>A0A6A6QK53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_110840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="102" mass="10999" checksum="1870BB2163E61F69" modified="2020-06-17" version="1">MELHALSGFIVAAIQPGAALADCRKQGSMCQLRSKAARLPWRPRAGGGECKEGALWVQVVRVVLLHCPDSFSCILTKPCRSHLGGLGEWTSFGTASHRLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKC4</accession>
    <name>A0A6A6QKC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_467514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="443" mass="49291" checksum="404CA7FD8232654B" modified="2020-06-17" version="1">MRDKRECPTPPNDGRKRCRPKRNIECRTKVKTGCATCRIRKVKCDENKPFCQKCVSTGRTCDGYESPFRHFTSQPTCVINAYAGRIKSDAGLQPIRPSIIEIAPQDIDLLNRYFSTKTMFDVKLDCDEEARQLLQASLTNPPIRHAVLSLRALREDLETTGDGATSVAQQTASYHYGLQQYGVALRGLVSSLSPPSSNGLKSALLCCQIFISIEQVRKNYAAMAQHIIRGLRIMHEYRARPHFVAANKLVPAHHDQLPFLDVFIIKIFAAPCKFADTPATADVSGTTSSVCPTPPHQQPLESRDLRTIAPDMRTELRRVATLTLDFLGKVSRVESVGTALRLLSEKTALLDSLASWLIDFELVQTEIGHPGPELISVSFLRLFHLILKIVLLGALDSSPDLDAKLRTEDDRLQGIADDVGERVRTYITCSGTSSGQEDRSKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKN1</accession>
    <name>A0A6A6QKN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_563888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKN1"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="458" mass="50229" checksum="45CC3ED9BDADF1F2" modified="2020-06-17" version="1">MTISNLPSADLKIAIIGAGPAGLGALITLSTLPFASATIYEKKPSVSEIGAGISIQPNTWRMLERMGAAETLRSSPFHRAEDGHYTQHRNGRTGKLVSAQFDSAGTPAAHQHARCHRGVLQSALLKRVDPARVKTAHRLTHITHLPSGRIHLAFDNGATDEVDLLIGADGIRSVVRSVAFPEHRIAYTGRTSYRTLVRAGDVAKIEGMEKEKEVVAFWHAPGGRWAYTCNLGDGVFEITTMVREGGEGVERVSWGKDVAAEKMIEHFADFHEPVKGVLRLAEKVQQYALFAGTRLPKVHIGAIALMGDASHPLSGAFGNGAGFALEDAYVVSQSLLWAHERNKSIQEALQLFDKVRSPHYERLYAVLDGYAATAKQLENPNLHLSFDEEVAVLVTSNWSGVNNWMHYYDVAKAFSEMIEDLDRKDAEKSAGNRDVIERRAKSLLDGNLENLVVEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL65</accession>
    <name>A0A6A6QL65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_551707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL65"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="305" mass="34582" checksum="430EDF4A107A31E6" modified="2020-06-17" version="1">MSALVRAVGQSGRRYVVERILQEKPMFLELGCVYLATSGNQKYILKSVQPKSFRYFRNMFDDIRNSPYSPYVRIADDSIPNKSMFAYKFFKGHLLGFVQKDVPLSVTKRILRDALRGIAAMHDKGIVHTDIKANNIMAEWNEKDGEVVVEQVQLADIEAAAYVPDNSVLRGEQLGNIMWRSPEAHASGEVHKPSDIFSFRIVCIYALIKRVIFAVGDEELHAGEEKSANVLERQISYFSDPEGFAGLLQHLGEGLWVQIFTVIADGFNEEYPRMPDVIGRMMNMDPKRRLTAHEALAHPWFADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLB0</accession>
    <name>A0A6A6QLB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_75260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLB0"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="266"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="501" mass="57145" checksum="8AD5B120BF3CE1EC" modified="2020-06-17" version="1">MISRADLEQTFRKPGPMVVNQQAAPTQQQMQLQQAQEANRRELMKRQSKKPTDKNIPDGVENICIGDAVQRYRELREIERTMDATMMRKKLDIQDSVTRTQTPRYGTMRIWISNTAENQPWQSTSMDPDAFDFESETTATYRVKIQGRLLDEDADLGLEPEGDDETATNDSNAMEEDGDKASKKTTPATRPKMFSHFFKSIVVDFDRPKSLQPDGFTQIEWKRPETATNNPANPPNMSPEANFSQIEFERKGDENINITVNLQRYENPERYRLSKPLAELLDTDEEDRAGVIMGIWEYVKSQGLQEDDDNRKIICDDRLREIFNNETLYFPYLPNAIAPHLLTLPPLQIPYTIRVDKDYISPSSDSGLQPSRPTVFDVQVALEDPLRPMITTMFRGQKHKEILETIASLDDSLALIVQAISHSKAKHAFHTSMSKDPVNFVKRWISSQQRDLEVILGEATRGGGEDGVGEEWNRGGKEGVWGSELARESVGLWLARQKPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLK0</accession>
    <name>A0A6A6QLK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_583744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLK0"/>
    <dbReference type="OrthoDB" id="5216128at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="14520" checksum="4E2B9AE44ABC3B05" modified="2020-06-17" version="1">MPSLRTTLRATSLLFGPLFIAFGLNAMLRPRHSLTFFPFPDPALPTSSAAPASKEVLDLLDALLVIYGARDVFMGVAILAAARGKALGWILVAAGAVAGVDGWVVRGFEARNSHPGGGKWGHWGYAPVVGVVGGLLVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLM7</accession>
    <name>A0A6A6QLM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_465418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLM7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="452" mass="49621" checksum="8C34C2E193701B25" modified="2020-06-17" version="1">MGYGGYFTLINATPYNWTQIYSHSYEMNTWAFPSIIIAESFRVYTELQEEFFLPSDDAAEVNYTIASPDSSGETAFQISFQNRHDPTGFDITWGDIPVQDYKPGDKANLGFEHDSEKDVQLVISGDGKGVPYATQYPYLNWMTVSMPTIGCQPLRQICIPGSHDAGMSEWNPHTSGAEQINIQTQQLDILGQLNAGVRWFDIRPVLAGGIFRTGHYSAVGPQMQGGDGQKISDIIEEVNNFTAPDGMNELIVLSLSSSMDTDTGTKRFPAFSRSQYTALLQAFLGLNHRYVAPSGTTDLTTIPLSDIIGKAPAILIIVNENGVDLSPFSNMGIYPAKVFPVYNSYANVDDVATMSADQLGKMKTNRTSPSDKMFTLSWTLTQQGTDVGVVWRSILDLADWAYKALYRELWGGDLSSNSYPNIIEVDDVRADGGVTALAMAINSYLSPGCPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLY4</accession>
    <name>A0A6A6QLY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_584102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLY4"/>
    <dbReference type="OrthoDB" id="5346581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="360" mass="41638" checksum="973D29528E40CAFD" modified="2020-06-17" version="1">MKLSQSAYRDNPYTISLPEPPDVKVSVANLDLEHLGAFKTILSKVLSTNVAKETYAQIIEGLPTRRVFYEYSNIRDRADINAHEHLSPKSSATLTAFGERFNFDILRFDAKTTQAYQNTIVGSKDFRLHLLEMIAVACHNIAVLIYKQIKGNEIPTERIWYHPAPIISSLPPRPDGRPDEPITFPPRLVLPTDFYHQFYQEMEQYPEGMADVVGYWAELRIFGGVVVFDRGESGDECNEAFIHPGKRRMIYQLHDHQIDQFVNFETAKGDEESDHVVSFNSVGTDEAARDEKTLGSPLPFRNERYHRRVDEWDALNQHIFRNRYERKWATRAPLAYRRMGGDEPEIEDMMVRHQTTGKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMI5</accession>
    <name>A0A6A6QMI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_563746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMI5"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Mondo S."/>
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</entry>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="977" mass="107402" checksum="AF801EABF5476D11" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP17</accession>
    <name>A0A6A6QP17_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_464533</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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        </source>
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            <dbReference type="EMBL" id="KAF2493866.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP97</accession>
    <name>A0A6A6QP97_9PEZI</name>
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            <fullName evidence="3">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_60725</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2493964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33609" checksum="0A47F3331AE6897E" modified="2020-06-17" version="1">MFGKKKAPANMEELKKMVASLNLPCTCPDCNPGAYNPQQVCHTHQEIRLDKDPKSNVSVPVLVPRSYEPMYLVDRTIEYINRESTQPYQLQKDARQRLRVLFLETDMMANLYAKNIKNFVSLKDLQHIFGIFNDLYFFGAMKNVRIEYKNRVWAAIGPEYTGFADTPSSGRQRSIVKIDPIQHHRLYPRKCGHEVLNTLLHEALHCFLDQFKSPRCKDKQCGFCSKRVENIGPEGHGRAWQIIAAKLEKAILGNWTLGWRLDMGRSTGFLHDLDHKGGQMPSLHDMTAWGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPQ3</accession>
    <name>A0A6A6QPQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_620199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPQ3"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="133"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="291" mass="32677" checksum="18D9FDD5B82E1814" modified="2020-06-17" version="1">MASNSNPWVWSEEYRRYYCISYDEESNPVYIWQDVTPSVAPTPTSLGIASNTATATQRPPPQTWAYGSHPTSHAAVNTTTNAVYSTPTEGANDPRRRDSVMTKKAPDLGNHIKGTNGDFEELDSSYSVRKDGKRFFKRGTLFSVLFSEGMGETQKMQDNENVTTVKYGGKVFTQIRRFVVVAEREGFCYACPVFTYTGRGTLKPGCRPWEHAVIYYSTLQSPITLDGENQMKNSPIGVKPEPTETRPLSTASRVQFGKVYPIDHNVKVKLLGKVITEHMGRLIAYYKNELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPS1</accession>
    <name>A0A6A6QPS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_61579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2494000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPS1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="82"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="535" mass="58648" checksum="DA4F89475DCA511F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPY6</accession>
    <name>A0A6A6QPY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_422600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPY6"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="627" mass="69947" checksum="2D240DFA1D02F361" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRQ1</accession>
    <name>A0A6A6QRQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_379177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRQ1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="159" mass="17463" checksum="463BAA37C9CD528C" modified="2020-06-17" version="1">MPSHSFDCTHPCCAVSRCLPIAACHSVEPLDGSASAIGISVLKLEADGVPDCPPHARRDGAIRSSKPLQKCQTLPSRMAFPRPDRVPRAEVTRVRGEALIAAGRLQLQLCLQSLEPKPSQHARNRTRLRLHMPTAHTKRFRIHRLPRPSCILVPVVGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRZ5</accession>
    <name>A0A6A6QRZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1769-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_511366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRZ5"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="466" mass="50681" checksum="870CCD303B2485DE" modified="2020-06-17" version="1">MTSALKSAFSTSRSPSPSPSTTVPDPSQKDKYLLRVTAGPTYSPSTHTLIPVNTPTPTHISSPLMDAWLNIRIKNYNGLPTTSPSTSTPYFSHPLHTADLHSVAYSFIPKRDIPGPDLVTGFDFDHSIRDRLPPGFKTAMRIVTTLLDPGIYADPYSDAPYLYGPALSSFFALRVGEKGDGRVNVEEGEVIEEGGDGSGAGVRERLGVPDTANKRRKHFLKRERLEGFVFEEGRRYGGDFFNPYLDFSNFALKLPGFSISVVRYIDDKTHELRYVLKDRETGEVGLVVIFTLLFGKKLEEALAAEKGEGGEQTEEERPAGREEKEVPVTNGVASEPRGVLDEEDAQDKDASMPNGTLSDLPMPTSKTEEQLEDDRPSRTHSSDVSATPSSETSEDSSSENVSYLTSTLYSALSSLGFGAGTSSSASSSAKSSKESSPSRQAGLNRHVEGIDDEGMEDYLRSRNAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSI2</accession>
    <name>A0A6A6QSI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_486334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="68"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="331" mass="35132" checksum="68E1875DD30F2642" modified="2020-06-17" version="1" fragment="single">MADDEVATRAPESDAQPTAAEGAEQSLFPGDTRAQAGASMGEHCTTDRPTPSGEVPTGEISKLGGVDVYISKPADYPHSPSKLLLLLTGGTGVKSANNQLQADKYASEGFLVVMPDQFGGDPAPNSVDQSAHDKHPSVIEQIKLRVGETAKSFLIDMWLARHTPEKVLPILHKVIEGAKEEFADAVANGGGIYGVGYCFGAKYIVILAGEHPDTVAWGQAAPGDEEQGVVKNAPVIKAGAIAHAGTMVAQEEIEAVKVPLYMACVKDDPLFPEDVLEEGRKGLEKNSIEHEIQVFSGVPHGFAVLGDYEDPNIKKSQTQAFGQMLGWIQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTA8</accession>
    <name>A0A6A6QTA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_527206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTA8"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="73" mass="7388" checksum="D04A738560256C97" modified="2020-06-17" version="1">MRLGLGLGLGGGLPSSGGLGLGGAGGLGGLLVMGRSLGGRARNLRREESKMKGETERPNNKTCTRNKTPTPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTT3</accession>
    <name>A0A6A6QTT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_608331</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTT3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="186" mass="19831" checksum="760FD5E5144D0717" modified="2020-06-17" version="1">MGDEKGTKTRRPQRDEQRETRDRRDSPGPTQGTNGRVVNIPGVQAVEPQQLQHETNERASCSATFPPSTASIGCRAVIPGDAHSGTAHGKLDAQSGRPPILFGSLSCLSLPVALLKHCDHRRPRAFELGTPGATARSRSRAGSSPSVGTAAAERMPCGLNTTESSERENTPSLVLQLQEPSACMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUE2</accession>
    <name>A0A6A6QUE2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="118" mass="12961" checksum="5FC6CC5C9D76A76A" modified="2020-06-17" version="1">MRTHTRFQPLRTPSLRRLRTAFSPPRGPRSASSSTASSTRTTSPLTRTSSPDSHFSAASSTTSSLRALLLLRRKPSSLDLEMEEERRSFGVELGMLEPRPSGEARGMGGIFEVLDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV42</accession>
    <name>A0A6A6QV42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_538617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3833686at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="95"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="123" mass="13409" checksum="1A1FD6AB8F728BF6" modified="2020-06-17" version="1">MVRIPFQRAVRDGPVISITKECDIINISVEFGEGPTRPSPRHKSALAKVIIRCTKCRPLQSSLRNTLATFGPESAQYQSTAKVVTDYIAQKTVSQPSTAMGKGKEKEAQGPMFTLAHRPKPAG</sequence>
</entry>
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    <name>A0A6A6QV46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_608677</name>
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    <organism evidence="3 4">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
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    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
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    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
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        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="123" mass="13554" checksum="B3DB8C4D8F56167A" modified="2020-06-17" version="1">MSRSLKTSLQSLKTWVFQSPSRVQKIASGQGTAGTRAAPTQAGPNDKSIGSRLDNGETFTKNGKQYKRYKFQVNKGANDKTLKQLADKDSHKVWAQADMPLGEADAHKATEALFDDLEKDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVY7</accession>
    <name>A0A6A6QVY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVY7"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2496611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="213" mass="21985" checksum="CA8A766CB61C4358" modified="2020-06-17" version="1">MASRGGFRGRGGFSPGGRGGGSNFTPRGGRGGAYQQSYGPPSAVFEMGKFVHACEGEIVCESINVKIPYFNAPIYLENKTPIGKVDEILGPLNQVYFTIKPQEGIQAESFKNGDKFFIGGDKLLPLEKFLPKPKPPPGAAKPKRAGGGRGGAGGARGGFSRGRGAPRGRGGFGDRGGRGGSRGFGGRGGGFQSSRGAPRGGSRGFTPRGRGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWL3</accession>
    <name>A0A6A6QWL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_525762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWL3"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2496606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="340" mass="39278" checksum="22F5FC097CE83C94" modified="2020-06-17" version="1">MPSTYKKDKPWDTDDIDKWKEDTFKPEDNIGGTFAEESSFMTLFPKYREVYLRTAWPLITRSLEKSGIACTLDLVEGSMTVKTTRKTFDPASILNARDLIKLLARSVPAPQAVKILEDGVACDIIKIRNLVRNKDRFVKRRQRILGPNGSTLKALELLTECYILVQGNTVSAMGGYRGLKTVRRIIEDTMANIHPIYAIKELMVRQELAKDPELVGENWDRFLPNFKKRSLSKRQVPFKVSDKSKKPYTPFPPPQEKSKVDLQIESGEFFLGKQAKERRAREEREEKMKEKMEAKKVQRLQEFVPPEEEGAVKEKKRKRADGEEKKKKKKKKAEVVEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXH2</accession>
    <name>A0A6A6QXH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_507680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="205"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="502" mass="56303" checksum="A49AE1937AD29FD1" modified="2020-06-17" version="1">MNIPWKPVPKITDNTVHLDDLQIAFKRTVRVPDDSNSSALPPGLGNFPLFEVREYAKSLPANMAAKGGLFLPMYRMYSYSTTSWVYQALTQLRLQHPYAVKIFVGGVNAFSGEPTLETHHTIRQRRNRVAQEISIQDYVVIPNQGWLDGICTEANRVRQFVAMPLGSGYSVEAQVTGQELIGGIQFEITPGKSTIYLLLNLRGGMQISVFTLTGKRITLQVDSSDTVDSVKSKLQAIEGIPPDQQRLIFDGKQLEIVDDRTLSDYYIGPDSKLHLVLRLRGGGDKTFPSQMSIAAGGKITQPVIKDPGIYSWHPQYTKVFNVQILNSAGFQKVTGLPMPESPINPALYKRYGYPYFGTYEEPLAEVVSGDFSQVKWVGQIDGVAELWREREDRKDAWFFNLSGPSSDFRTLEDLERQVKREIELEGRGTSHMGAFQLHRGIQEAVSLRVVLYFYPCNPLLKPCNLQLSVTGRETAMFVSIALAVVSLSNRKMKSIKELQQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYJ3</accession>
    <name>A0A6A6QYJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_311608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYJ3"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="360" mass="40004" checksum="3B0EAD333C7821E6" modified="2020-06-17" version="1">MAHISEEESDDDSHIGYEDWVKPELCAAIEGITRDEDFAVFGTRMNPVNPGLRVSGYGDIRIPLADEHFGPRPSFVVGPAQLLAHCENAWTCFGFQNPSGLAYINELQSQVARELGIRSGHCSKPTLLLCSQVSSTTLPSQSDDSIATMVFCLPSRHLGGEITFNSNGETKAFNTDQTSPFDLSYFAWYSDVNVKLAPVTSGRRLLLVCSVYKGHEVVGFQNASTIGASKKELQRVVTTWQRSLRSDQPCSTHFAYILDSVKGLELQVSGLDAIRVRNLHEICQKTGFRLLLASMERQVSGICEYDDDLCKYHTMEDELEWKVTLKCIVELDGTEVARDVTKRRPMKAVTAVEHTSGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R095</accession>
    <name>A0A6A6R095_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_342641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R095"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="372" mass="39893" checksum="CFC9203B5B46CB38" modified="2020-06-17" version="1">MPAPSSNSNDQSPKLLVTASDAQTFVENVLVGNGVPRENASIVAKCLVEADLRGVDTHGVNRIPSYMARIRQGVLDPQASPTLHKITPVVAQVDGHNGFGFLAAHRGMSTAINMAKEMGIGMVSVKHSNHFGMSAWVVQQALDAGMMSLVFTNSSPALPVWGGKAKLMGVSPIACGAPAGKNKPFILDMAPSVAARGKIYKALRRGEKIPKDWALDAEGRPTDDPASALEGVMLPMGGPKGSALAIMMDVFSGVLSGSAFAGHVTNPYDPSKPADVGHFLVAIKPDLFMDMEAFKDRMDYLYKRVVDSDKMAGVDRIYFPGEIEQLMQEDRLRNGIPYVDAEIEALNKEAQKVGVESIKSRNPPIVNEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R097</accession>
    <name>A0A6A6R097_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_559667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R097"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="76" mass="8320" checksum="A08D6320964ECD78" modified="2020-06-17" version="1">MSPSQPPQAHLAQPTANREIEASQPQTQQPMRMMQQDPQAEQKTVGMRGGDGRGGMCPGRFCFCVPCPLPCDFCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0I3</accession>
    <name>A0A6A6R0I3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_536290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="450"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="477"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="651"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="562"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="680" mass="73138" checksum="D2499BC8F606166A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0T7</accession>
    <name>A0A6A6R0T7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_330949</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="208" mass="22991" checksum="6370291D910980AA" modified="2020-06-17" version="1">MMHRQVPGLICDDDDMFRDSRSNEAGRTGGRNAISSEAEGEGARGRCMAQTSWVRYRAFVPSGEEADGNERKQTAAMARGVELEGGRADGHGGSQRGRVVGGVGGWDRWRASWWLTGVKRALGRAMPHLGRERSTPKPRGRFPIGRDGWVYFSHAASARAKPDSFCPTAPIHAVQTAADSWEIYPGMWRKVKPFCRAFLGPQTLYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R155</accession>
    <name>A0A6A6R155_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="55"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39493" checksum="17D4FCCFC2B4173D" modified="2020-06-17" version="1">MEKYSQFRDRGTAIAPFFPVTSPPSGLLWMPVHLFLFAIRVPALLCFSMFYFTILRWLPVGSFAKKAVLWCMIGIPGIWWIDLQIDRVKRGSLNSKAALARLPSAGTIIASSLTSPLDALYLAAIFDPIFTASYPGTRLVQRISLFRAMQLALLPPQLVPPRSSADKLVPLSEILARYPDASVVVMPECTTTNGRGILPFSPSLLSAPPNAKIFPVNMRYTPGDITTPVPQEYLRWLWRLCSKPTHCIRVRVAECVYNNPMLTSPTPASSSTSRSTGLDTVANNSYETNFFDTADIGDGSDTLIGSDDVEDGLTPDERRVLDRVAEDLARLGRVKRVGLGVREKIDFVKVWGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R184</accession>
    <name>A0A6A6R184_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_524645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R184"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="496" mass="53254" checksum="1F51B0F358C4A033" modified="2020-06-17" version="1">MDPKKRRVVLIGCYISLSGLLYGLDTGSIGPITSMTQFTASIGPLTPIHQGLYVSSFLLSAALSSLASGHVADKISRKYGILTGAFLTLAGTVFSAASPNLAALICARLLTGVGAGQAISVTTVYLVEIARPEVRGTLACLIQSYIVSGVALGYFISYGTRGIAGSLAWRAPFIIQAVVAACLCAGAGFMPFSPRWLVRSGRSEEAKRVLLRLREPLEAEQELVEIREGIDAERQRPDAGWSEMFARRYVGRTALGCFLMAFQQLTGIDAILYYAPIVFQQAGFTAERASFLASGVSGIIMVLCTVPAQIWVDKWSRRKTLGIGGMACAGCFIVIGSLYAKYGSVQDGGVVLSSKPAQWTVIVLIYVFSANFSWSWAVVGKIYACEIIPTRLRAKVCAVEQLTNWLVNFTIALTAPLFLRSSPSGPYFLFGFSTLLAATVCFFMPETAMKSLEQIEGLFEKGQNLRSSVELEVGNPPQMSTAEDMVSVVPKGGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1X1</accession>
    <name>A0A6A6R1X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_616501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1X1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF814">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="350" mass="37902" checksum="85DD339A31FD208A" modified="2020-06-17" version="1">MPHTLVTGANSFVAAHIINELIAQGHTVTGSVRRTAAGDALLAENPEWAGKLDFVVVEDYAKDGAFDAIFQAKDYDHIVHVAAPLFGEKQTDFDRDFLRPGVDGNLVLLKGAKAHAPTLKSVVITGSINSLTGGSPAENDSTEYTNDFWNPVTPEVARESGDQYVMYQSSKKEGELAVWEFVKNEKPQFSVTVLLPSLIFGPPLQPLPDLKHINFSVGVVYNFFNGTFIETPQTHAAGLFPSYIDARDLATAHVRALTTPGAANKRFLVGGAELTSTLIVETLRGLVEKGELPELKGRLPKNTGKDTDLSLARIGVKEGNDVLGLSFRSAEETFGDLAKKVLELEKKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R201</accession>
    <name>A0A6A6R201_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_525456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R201"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
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    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="7">
        <location>
            <begin position="85"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
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            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="47255" checksum="DEFC0E935B7FA075" modified="2020-06-17" version="1">MFSRTLRASVAAPLRRSVFAPVARPAFRTVTTDAASSHADKDSVPSEDDKPFEVRLSDESFETYELDPPSYTLDTTKKELKQMYYDMVAVRRMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHALQKTDHLITAYRCHGFALMRGGTVKSIIGELLGRREGIAFGKGGSMHMFSTGFYGGNGIVGAQVPVGAGIAFANQYEGKENVTLALYGDGASNQGQVFEAFNMAKLWNLPIIFGCENNKYGMGTAANRAAALTDYYKRGQYIPGLKINGMDVLAVKAAVAYGKEWCRQGKGPLVYEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDPIAGLKQKLLDWGVTSEDELKAIDKEARSNVDAEVAEAEKMAPPDPTPKILYEDIYVRGSEPEFLRGCIPEDNFYYTESEISKEAPKKAAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R281</accession>
    <name>A0A6A6R281_9PEZI</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="6" type="ORF">BU16DRAFT_455393</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 269.34</strain>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="469" mass="52143" checksum="D664E48347C04573" modified="2020-06-17" version="1">MREIDSHFDAYEHMKHLPREQEALVMLRKAASAAKPMMRKRGWKVGTLAEFLPDQENLLGLNVNKTERILIRLRYHYDSRQFLPLEQVIDTLLHELSHIIWGPHDQNFQNCWNELREEHQSLLAKGYTGEGFLGQGKKLGGKRVPLTEMRRQARAAAEKRRSISAITAGSGRKLGGSPVTPGVDMRRVIADAAARRNSITEGCASGSKEAGKLSTDASKIGFRTKAEEDDANDRAIAQALRELMEEEEMTRLDELYAPSGAGGLAWDRENGLSFDDNSQPQSPGLSWNKEKGLILDHPKPPNRNSRPVSRLLTENPGPFRTPSSSTTSSANRASRPPSRLISEDDEQRRRSKALPSIPAFEQPLEPVPSSDPDKWACPQCTLLNPLDFLSCEICGLEQPPQPIPRSKRYGPAQRPPLPKAPPAASMRGPGATPFEPAKGRLGWNCLNCGTFMENQWWTCSLCGTMKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R298</accession>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 269.34</strain>
        </source>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="12"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="75"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498659.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1273" mass="140536" checksum="843FAF841A2B375C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2A4</accession>
    <name>A0A6A6R2A4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
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    </protein>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2A4"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="431" mass="48465" checksum="B714A7EDC980A231" modified="2020-06-17" version="1">MVYSPKQLEARELLEKRTVLAFLVVTWIFIILRIYVRGHLIRVFGWDDTWMILAQLTFTLYSAFFLVLLSFGSSTVMMNYELQTKITNWSIATLCLYIATICFLKISLGILFNRIVVKRWQRFVVYATVAVSTLTSIAVLLFIVFRCGTDVGDFLPRIVAGQCATRRTSLVFLYLHGAINVATDWIFATLPIPVLWNANMGTRTKISFGFILALGAVGSICSIVRCFYIHGAFRRDDFFWNSAMAATWSTIEPGIGIIAASLATMHPLFRILFINARSFSSRYGHPATNLSKQTRRSLPFRPPPPPASTPDESPDVSAVEMRRSPSNRGSDAAVKPLPTSTIKVVDTGDGYTARKMYIRPHNTGSEDVIIEIERESWYMEPSDDDRSSRQSTSLELVNQAVGALEEYIGTHGLEDGTVELDRRSLHTIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3B5</accession>
    <name>A0A6A6R3B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_559018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3B5"/>
    <dbReference type="OrthoDB" id="3946158at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="388"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="446" mass="49649" checksum="E5622A5B6566A273" modified="2020-06-17" version="1">MLSKGSGKGPISWNPQAVPQGTSVDGEDKISPLLPRKVGQSVASSHPNGPPNLLLTREKYKDRKELDQGSLLQVLGKRSRFEQPDFYPSRTSRYPSASALPPRAALPARVDYRRRTDLASSAPLVASSKWASSGHGELNNTGLQRKRSPVVFDMNPPNSARLAAIQGNQPGNFSINWDDFPPHTQQQRLQYGQMLQLQAQAQAQARMNPSMLGGVGGIKAIQPVTPRESIEPQDYAKQIFDSVALANAGAAAARGQQITLTIEGESRAASSDVDVEDLDHEEVSYLTHGVRPFQMAPAQSAGLGSRSSDIKQGGGKDRTKIDNNRRLVFGGVQIYTRRHPLYDDLELKRGPALDFPEILGEEHRKSTWTEIGRGYKNHSQRYPLTEVLEECFQQQHKPSASTKKEISRRYSIPIDKINNWFQNRRAKVKQDLRNQMVNFDGLWKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3G9</accession>
    <name>A0A6A6R3G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_524572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3G9"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="54825" checksum="77AE50C9EDB8CC48" modified="2020-06-17" version="1">MAPIDFFKAFVNCITDRSWWWRVWTVQEFYLPQRVQFQIGLRRIPLEEFDLVFQVLTSAYKSTFGRTDEQYLAETRWINGFDRITQMLNLRRGRQIDIFGNNGLYEVLCRTYCPFRFQESDTYLLKATCRIDQIYGLVALYDDFDVLGLTIDYRKTWQEVYSDVAQSLILTDNMDVLAFCQRENASQSSTLPSWVPIWHEQFDTPHAWWKAPRKPDLSALGNSLFSAASNFTVEVSFETTVNTSGQSTRSMQIEGVFVDEVSEIKSQYFRAASIHYTEKKEFVYVLYGMLLGEIQALCDLSRSLKNAKYTPTSLQDAAWRIPVWDHEIQEDASWTRAGEATRLRYQQCMPVYETVQKHMDQVKLSADSSKVLQFPLLQLGAQINEILRQYMSPIILGRPSKPFMTRNGYLGMGPASMEPTDSVCLLFGARVPCVLRKRPGEEGGYVFVGEAFVYGIMDGEFLREDQLSTTFEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3U4</accession>
    <name>A0A6A6R3U4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_523920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3U4"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2499438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="176" mass="19440" checksum="28D8EF340B497DC4" modified="2020-06-17" version="1">MDMSGMMPASEMVMTFFTSSSTPLYSEQWSPKSTGAYAGTCIFLILFAALYRGSFKLLHFLEHKWLESAMKRRYVVVADKTPIAERISSDADSKTAVISANGVEEHVMIVQSPIQHIQPWRFSVDLPRALIYTCIAGVGYLLMLAVMTFNVGYFLSVLGGVFLGELAFGRYGAPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3U8</accession>
    <name>A0A6A6R3U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_269809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3U8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="187" mass="21081" checksum="A96558B6C0FADCB8" modified="2020-06-17" version="1">MYKCINTVDTPDSQLTRGVFNVQKPHKPTPCNASGFWLEMRAVFQCLVLDLCTFSATIRGPSIRVQKIVHCRTMVWLTVDVLGMPNQLVVPVGLYWGLDRRWTHAETCPKKGCAHIYAKLADRRVLCPVVAGCCRKCELGPESVDVVRSLRSFTIQSPGHYKGLRNISRVQFSQFITCKIMARQIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4C8</accession>
    <name>A0A6A6R4C8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_277848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4C8"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="182" mass="19788" checksum="7ED10BA0010BBB11" modified="2020-06-17" version="1">MSNPRIEELPEDEPDKKIAEVEDAESSSDSEVEASGESGIPAGASVAVHSRNEKKARKAIAKLGLKHVEGITRVTLRRPKNILFVINQPDVYKSPTSNTWIIFGEAKIEDLNSQAQASAAQQLAQAEAQGHDHSGHDHDHDHGKGKDIELVMQQASVSRKKAVKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4D9</accession>
    <name>A0A6A6R4D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_548115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4D9"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="661"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="876" mass="98620" checksum="89E0C5DD42DDEF52" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R579</accession>
    <name>A0A6A6R579_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_524180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="504" mass="55571" checksum="58B5200B963AB695" modified="2020-06-17" version="1">MSFIDSAAQQSGIPLSTKVTVLFITLLVLFLSYVVHALYLSPYAHIPGPLLSRLSNLPLYYATYKGNEATTIGRLHATYGPVVLIAPNEVSVSDGRALKTVYTDAGGFRKADCYRNFDIDGFPSIFSELERGNRAVRFKSVSGLFSTGAIRDSGEEVIKDVAQRWIAYLRQAKGGAKGHGRSADVLKAARAFALDAVTGYLFGECYGALAEIAQEEREAKGAIEKISASLFVDSFVAVGRFFYLPSWVFTLLETWSARLAKDKVQVEESLETVDGFVGKITEETAARLSDEKEENSYQARMLKAGISKEETKAQCKDLMFAGTDSTGMNLATICWYLTKDQEKYKKLRAEVLANPDSSPHLLPYLTGIVKEGLRLSMANPTRMPRVVPSTGYTLPGGQFLPPTTVIGLQPYTLHHNPAVFPSPNEFIPERWEDATPEMLRDSIPFGLGSRACIARNLATVELYIAVDTIVRDGLLEGASPCKSKIEILEWFNSKVIGEKIEIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5B8</accession>
    <name>A0A6A6R5B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_536059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000053">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22788" checksum="01B5BFA88FB10E59" modified="2020-06-17" version="1">MTQAAEKVTLPLKAGIDLGSGEYKTALESALKALSEAEGAQKVFWGTQVEHPEVLELSVDWRQASDFQTFINSAAYPGFRTTLGTIVGGPPKINILSRFQGEAFSTAVSVPIAEVVTLTYPASISEDDANASFAKFKSFGDKADGALALVGGWSVEEVPPAEGDAKVFVGVIGWESLDAHMAFRTTEVFKEAVEALRAGSEGIEMHHVKFTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9P3</accession>
    <name>A0A6A6R9P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_201684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9P3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="102" mass="11442" checksum="1D93CEE63106AD0B" modified="2020-06-17" version="1">MPPCRTRRQLTTRLTCPSKHRSTCTFVIKLSWPKRDVLGIAAKNQSQVHRASLDRKRWRQGGDQLAAPLCLLWYGHLTCHSLARSKIGFIAHATVQGLPSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA78</accession>
    <name>A0A6A6RA78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_450950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA78"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="137"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="457" mass="49838" checksum="E1B83DF7797DF77F" modified="2020-06-17" version="1">MSYGYPGGGGYGGQPHQGYGAPPPQNYGSPGYPPQQYPPPQQQYGGYPPQPPHSPQPPYNGGYGQPTPPPQQYGGYQQTPPPQQYGYPPPQNQMLPPANQGYVGGHGAPPPPPTQAQGFGQGAPSGYSFQYSACNGRRKALLIGINYFSQRGQLRGCINDVKNMSTYLNGHFGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRTAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYLYSTQGVVKEPNLAKEAGQGLLGIVSSYARNDMGGALKGVSGLFKKITTGDDVYQKNLRTKTSPADVIMWSGSKDTQTSADASIGGEATGAMSWAFINALKKNPNQSYVQLLNSIRDELQGKYEQKPQLSCSHPLSELFPSLLTPKSLKSAHWPAANQYLSDTDLLYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAE1</accession>
    <name>A0A6A6RAE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_555993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAE1"/>
    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="336"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="532" mass="59103" checksum="0D2FAF171C17C9F0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB21</accession>
    <name>A0A6A6RB21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_556222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB21"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501751.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="198" mass="22417" checksum="AB3C694AD2FED13D" modified="2020-06-17" version="1">MYKPSTGDHLFSFSRFINNAVPNLALGPRADDLTVRERDQLFEYQISILEPSKLRPLAFFMGGITANEGLSAQIHAALIKHEVLSASSAAINTEAITPKFAHQLSIISSFAQKKLVNLLLFWEEEQQRWRVLLEEEAEIKGMSVIEAEREDEGALGPLGKRLEEIEGMIRLKPSMRSIEVRRVDQLPNDKQVYGSRRL</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Gonzalez J."/>
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                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="20"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="114" mass="12458" checksum="877959F9EABE46F7" modified="2020-06-17" version="1">MPTSTPKRYSFAESRLSRRLFSIGDAITTAVIGVMCFGFVKRLLNTKDETEKSSAYTPSVPAKSTKRPIPGVTELPAQSADPPALPARSTKRRPVLPALNIPQISTEFINDIKI</sequence>
</entry>
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    <accession>A0A6A6RBT2</accession>
    <name>A0A6A6RBT2_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="26218" checksum="1DD050FFA044302E" modified="2020-06-17" version="1">MFRGSSRPPLCASPRVRQRRCRQSGTERADPLSAACFYFHCRSTRSIFTGGRRNRRLRHRPGACRPCACWTAGVAWQSALVPRSNGLLTCVVCVCALQRRRGVHGGNAAAVHGMADKDETVSRRLGAVDGRARPSATREGGVGSRPGPGRRPVLRPHVLILAVGGGSWKRQVGVQAASFRVGRSRSCCMAWHGHGSVSDMGGRVETAGLESRDVGCSGSGIDKGALHHRHRGLNEATRPLSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RCD5_9PEZI</name>
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            <fullName evidence="4">MYND-type zinc finger protein samB</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11750" checksum="1DFB0B8FF88ED8CE" modified="2020-06-17" version="1">MSLSMRGLEDSQFEVEDEHPSDMSTDGDADYTMEENEDVDSDKGPGEDGDFGSIETPPLIPSVHCVMCNNAASLDYSTYHSIKYCFESCKKGDLPVHELLCQKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCF2</accession>
    <name>A0A6A6RCF2_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="121" mass="13534" checksum="EBC955BF84BB2083" modified="2020-06-17" version="1">MIPKHIPTGPMSSSDEPKLPTEPASQEANPKPFSIMNIHVPRKTPSNPSSRPTLNRTPSVQTRYMNMLLALGRHVVVGRICDEKGPIDSHNTWIFSAAYGFVFFRGVDDRLVQAREVVPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCL7</accession>
    <name>A0A6A6RCL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_554206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6RCL7"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="218"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="437" mass="48924" checksum="3F4832F46D736B99" modified="2020-06-17" version="1">MDALVAVAAGEKKNEQSELLAVAQDIQSITTELVSSLTAFDSLGVATADVAALRQFAVTSQTLAGSLVDLLNKINVPNPDNKILIKVRDVIRVMQKKGQVDVLEQRLSRLCAQIILHIHLAVVPALSSSIQSMKDDYDTAFAAILFRLDGLSRNAAAQTVAPLVDQPILNGTLDALREIATGLEKLNQARQQRSVLQSLSFVQMDSRKCTIVESHEATLEWVWELYEKWLGDGVFWVKGKFGSGKSLLMKFLAEHTKTEQYFRRWARENNILIVAHYFDYQGNAIGRSQEGLPPTVLFQILQKRPELIPTICANRLQSDPHGVTTWTLHELSECFLNIEKIPDLPICIFIDSLDEYDNSLSDLLRLVLKLSQSPAIKLCVSSRQLNECEKAFRNSSSICVQDHTHRDIARYVKDNLTQDFEPLEHEDPSGFVSTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDJ1</accession>
    <name>A0A6A6RDJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_545898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2502631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="562" mass="61894" checksum="BEA80533C06518BD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDT1</accession>
    <name>A0A6A6RDT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_211752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2501900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1486"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="638"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1486" mass="163837" checksum="06965A6B19D4176A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE08</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_498427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="13666" checksum="AC94B3E5D22111BF" modified="2020-06-17" version="1" fragment="single">SPRHFLSQVLQRHHTRSTKPPSRSPPRTARPARRHSSHWQAASHTSGPSSKTPSTAEQSALLTEASAASFKGNHDVIFGRDDTGRLRQDSPGTSRACLDIAPWILLQRPPRPRSCRRGTGVLPH</sequence>
</entry>
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    <accession>A0A6A6REQ8</accession>
    <name>A0A6A6REQ8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_554894</name>
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    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5025398109" description="FAD-binding FR-type domain-containing protein" evidence="9">
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            <begin position="19"/>
            <end position="794"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <sequence length="794" mass="89568" checksum="DDF99FAF1C5733F5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="similarity">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="186"/>
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    <feature type="domain" description="GH16" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2503169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="620" mass="69281" checksum="1E2736410B5DF8C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REW9</accession>
    <name>A0A6A6REW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REW9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="40465" checksum="EBD02CC119EF8C84" modified="2020-06-17" version="1">MASFISFFNPSPRDDFAGPFKFSPFHKDNVLDLVKQVGVNGGKLQSTDIPQAEPTVLAIHAANYFTNGLDLIGILWRTGSDGTGHYEFQWAGALDNEAVDVWQIPYQVIYEIKRDGKVRNPPDGLLAWRLTEPMVEQLLGPENIGKESTEWRIWNSQLNFYFKMRFPVDLEEGFPEGVELATFCAVPCVRVYIEPPAVLNSIMASSYSFPMPKTDFPGSFQFGPFDDFNVMKLIRDAGDSEEDISFGLDEIPKSTSLVVLYASNYFTNGQDLVGILWRGGLLNSGHYELQWVGAIDDQTAMGWALPCNEESAIAPDGGRVGDPPDGTLVWGEDLEDDANELNEWQLWHTALGGYCNRKREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF76</accession>
    <name>A0A6A6RF76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_39086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF76"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2503385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="434" mass="48733" checksum="61A7EFA3900A4BF1" modified="2020-06-17" version="1">MAQPHDTSDGATLNKSPSPAPVPSTSPSGKLPAELQSCIICRKKPARLCATCRSCSYCSKKCQKEDWPTHKFLCKAYSNESRPTAQHKRAILFTEENERPSLIWVHCTDYPDEGVETADLSPYMEDLAPSVSVVHFNHRLNQVLEDDIIVYNLDDYLSESKPTRSLYRATAPLGFPAVQWRGPIMVMRKVGRGSDAIYSTDMTLADYRNILDYFVNYGKYNATGIEECGKEPEKTANTMRGVKITCKSEQDLRGKKPFVAVQVSTNHAATLDGEVSPISKLVNMPFRAWKIPQSSEARGHGNSLANQAALFLMIDTNPKRPRWGFAPRHWQHGIGDVLLVREDGEDLTLEQAEVLSRFCQYKLIPMVQQATETEDFVVSYRQPLVGITKQSVVDFITAENVEAFKKEMYEWRDAGKDMGEFFESLDAWSGVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFM9</accession>
    <name>A0A6A6RFM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_554600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFM9"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="602" mass="64570" checksum="0B8B7E0B389C94AC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGV5</accession>
    <name>A0A6A6RGV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="363" mass="40942" checksum="4A2A4B5B1440E6A0" modified="2020-06-17" version="1">MPPPLPRRTGHQCLFYRPSCRTFATTPARHAGISRASPNRGLKPSQRATQSPTLMLKEQHKGAAGLRGLPTDMGLLPGTIIKPTGKNLPSIFRKPRVRLDIEWQNLKRGTMDRASLIHWKFFLKAWKDRPRPKLERRKLVPLAKDYHKQIYSAFAAHDAPTITRLCCSGLTSDFRTRMSHRAPGTHLTWTLSSYTSSPKIVSNRATPLPNQEHTGVRQVVVRLRSKQILTTWTDEQARRAVASRIEALRAAGREVSPALLAVESENEKMAVSAAHGGYNPISLHRINKALSEDTEALAATDVEKVETEVTEYMVLQRRMLEGVEEGWMVWGFAEESTPEVRARDEKQLKEMEEYQKSQAAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5140945at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="314" mass="36193" checksum="61D28A81D8E5BF43" modified="2020-06-17" version="1">MTSPEGSSAFEREFVREWTAVHYNFNRLLELIQQVARHDPLPNYCPKMYERRKNQLLDLMFYYTTSIISNAMTTILAVGPQNRLHEKLVEMESLRTLISQQRENNPFHFMYSAKEVGCPSLIILFLKMAVARGMVSSDPGKIQQLMTDIHEEKRFKKVHNYRYTPGILACIMVLSRPGNKNIITATYDKYNFELEKVLEEFSAVTKDTRVEKRPVEVNSQQVKDFLAKHSSSQKRVDLTAPSGSILATFKPNGKYMGSCLLDYYRFKTERPEGNRRKMNAIFGPAYCAKWFSFLELAMLGEDLPTTALPDTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAH9</accession>
    <name>A0A6A6QAH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_553739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="59"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        <location>
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            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="191"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="322"/>
        </location>
    </feature>
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        </location>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
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            <end position="498"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="527" mass="56857" checksum="775C68318028ABEC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAV6</accession>
    <name>A0A6A6QAV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="276" mass="31347" checksum="E32670256D3774FE" modified="2020-06-17" version="1">MSSIDPKLQELDAELARVWRGILEIIFEPCVPYVKETEGGFLVSGKEETGYKLITKDEDLLTFIMADQCDDAAQVLYDIVQKIFGTEVQMTQIEVKPKRAALWPNRINKARVRGHMVLLVMLPDRTQLVVDPTKAQFGFQECGLSLQKFLKDYGVKGDETIPLIFDRETHLQEMEIASKKMVKAMKNMEEAFASLGSFVPGPQYRPQDHYELFQHLRERLSEAYDVWRAGIDDGSSVVEVLSQENVGRESFRKAMLDGAEKAVKDSKGGKLPRFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB32</accession>
    <name>A0A6A6QB32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_553385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB32"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="613" mass="68588" checksum="DF9839B0BECDDAE7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBQ9</accession>
    <name>A0A6A6QBQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_544492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBQ9"/>
    <dbReference type="OrthoDB" id="10552895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="206" mass="22605" checksum="2DB95245F65514AB" modified="2020-06-17" version="1">MLFKLTSFGEQEPTPPPPPPPSRAFFDFSPIVHIDSFEYQDGVSLSTRPRAPPSEDPPRAFFTFGPTYHVPRPNPRRTSRRDFQPASPEAREELFNHRTRPTTTRVPAPTSETNSPGAETYHPGLGVSTSSSGAPQSASDDSKFTLADSESILDDAASSWDEVQSILDASDRLSTAIGSIIGTLLTIKIGLWFLRVLGLTPRKHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBU4</accession>
    <name>A0A6A6QBU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_586048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBU4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="150" mass="16985" checksum="016218A44DD48379" modified="2020-06-17" version="1">MSQTVDLRSMTNVDLADGLFICCIVSGSWYRPIESQPQQSSTCNPFFHSNSRPSSPHINMSDSVEERLARLEEHTYGIVQGDMHEAEFKVGDEAWFDNTTDDDLLEGSIKSTVVARTRGRTGFYYKLSYTDGNGWEQTVEKSQNDLRTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC49</accession>
    <name>A0A6A6QC49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_162443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC49"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="189" mass="20545" checksum="CDD2809DDD62053E" modified="2020-06-17" version="1">MTSFFDERALGYLSSIPWCNALLEDPAYVVLRGFPPRTPSRGTTCHTLTRDTLNTRTTMPAVVSLYKKPLEGNFIAEATVLVALGSDVNGHADTAHGGLVATIMDECAGLIQRLSQTIGGDARCPIYTAYLNVRFKQPVKTPGVVAVDSKIVSMEGRKKKVLVQMKDQGRSVLAEAEALFVRSKEVAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCB6</accession>
    <name>A0A6A6QCB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_518302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCB6"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="495" mass="53656" checksum="35DA906315793844" modified="2020-06-17" version="1">MSADPVDTGETPAAPISAPSDAAPPQDAPPTAEKGAPEKPALSGAELKKRAKAEKAAKRAQQKAATDGTSGAPHDSKPVQQEPKQQKKDGKQAPKEPKQGPKEAGQPGMPIPMRRRQSVTLPPPKEKEEVIKQVGLFGHLYGQPKQHSIAAAAKEVHPAILALGLQYSSYVICGSTARCVSMLLAFKKVIESYTTPKGQALARHLTSHHLSPQITYLQACRPISISMGNAIRHLKDLIVKIDPAVSEADAKEHLIDSIDSFIKERITAADELISEEAMRKIAEKGDVILTYASSTIVQTTLLKAHDAGKQFRVIVVDSKPLYEGKALARNLAHHGLQVSYSLISSAAHAMKNVTRIFLGAHAMMSNGRLYSRIGTAAIAMLAHERDIPVAVLCESVKFTDQVALDSIVKNELASPEELLSENERSALVDLLPKEKSSSTDKHEDVMKWWRDEPNLQMLNLLYDVTPAEYISIVITEFGSLPPSSVPVVHRISTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCS1</accession>
    <name>A0A6A6QCS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="3">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_575478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="3"/>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCS1"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="10">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="394" mass="42435" checksum="C0418ED35F92CA9E" modified="2020-06-17" version="1">MAQNTALLETHSVSAPPSTATTLPTIKIGTRRSALAQIQARAVEKQLKDAFPDRTYAVHAVLAQGDLDKVTPLQQLSQGENAKSLWTGELEAMLELGELDMIVHCLKDMPTQLPPNLTLGCICPREDPRDVLCVSPKLASTCKDLASLPEGSVIGTSSVRRAAQLRRLYPGLKFADLRGNVPTRLAKLDAEDSQYAGIILAAAGLIRLGIQARITQFLSKDSGGMLHAVGQGTLAIEVRSNDTTVKELLAKVGSERNARASLAQRALLRTLEGGCSVPIGVETEWKKPKKGVATGVEPAREYGLDGKAVEEEEDDDEVGDDEELLLRAIVVSVDGKEFVETEMVRKVASVAEAEAFGQDIAKILVAKGADKILEKISKDKQWDAKKRLEAEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCU2</accession>
    <name>A0A6A6QCU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_434759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCU2"/>
    <dbReference type="OrthoDB" id="3917514at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="88" mass="10414" checksum="DD60C75492AF0917" modified="2020-06-17" version="1" fragment="single">ETPVKAKVKGAIKFLEAKGIKGQKEDVFRHFKVSHTKGYWMLLDYPRRHYNNPEVEENRGRKSLISWQDLKNMEGILKEYSFLARVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDA3</accession>
    <name>A0A6A6QDA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_567167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <end position="42"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="515" mass="56778" checksum="DD49ABFFBEB764F1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QDI6_9PEZI</name>
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            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_495487</name>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
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    </reference>
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        <text evidence="2">Monomer.</text>
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        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
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    </dbReference>
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        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="260" mass="26905" checksum="1AABC223FFFFA84B" modified="2020-06-17" version="1" fragment="single">MLTTSARGATFPLLPGLDGAGTISAIGSSVTRFAPGDGVLALFTPGGAGAAWQTYAIVPEESVAKKPASWSWEEAAGLGVTVLVLGGSSGVGAAAVQVLKLAAPGCRVLATSSGKHHGLLRALGVEGVVDRASGTLVADIRAASPGERGVDAIFDAVGAGATQRDVFEAFRVDGPKRYAQVWTGDEEIEVPEGVESVLFRSRDLSKLKGSKNVMVALERLLEEGRYKLPLPVRVVGEGWEAVEKGLEEMRKGVSGEKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEB5</accession>
    <name>A0A6A6QEB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_517754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
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    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
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        </location>
    </feature>
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        <location>
            <begin position="517"/>
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        </location>
    </feature>
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    </feature>
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        <location>
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        <location>
            <begin position="680"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490449.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="690" mass="73984" checksum="272B725E24086B30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QES4</accession>
    <name>A0A6A6QES4_9PEZI</name>
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            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_530486</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
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            <dbReference type="ChEBI" id="CHEBI:24646"/>
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            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004368">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAO_C"/>
    </dbReference>
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        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAO"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
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    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
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            <end position="482"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490895.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="727" mass="79684" checksum="CF5619E3D9CE5DE3" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A6QFI0</accession>
    <name>A0A6A6QFI0_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="19002" checksum="8F78A725C0E2ED5E" modified="2020-06-17" version="1">MPSVLPRAPSSPPSDRAENRAEIRSAIAASTCGWSPRTLSVRRSRCRNKHFCWQFDLPLKHQRRSPKKPQASPTPITQSRPRPASLFLPPPAHRWLARGDKTAGPAWPCRGQQVGGTFVWRLARACAANQHVGGRVSAIFAFSSWPRCVWRVLQRASQRAGSRDASWCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFU8</accession>
    <name>A0A6A6QFU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein YMR-31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_530494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFU8"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13103" checksum="0804FF150764AB49" modified="2020-06-17" version="1">MNATKQLLQHRQPMIRFLGKRHTPTSIDHTPHAHPASPTHSLPESFASYRQKAQQHGPLNQQNHLPIGAIGGKPGASLGPVEAGKGMFFDRSELPARFQRTPWTQAEIDAIESGGASMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJF3</accession>
    <name>A0A6A6QJF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_529689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2492352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1294322at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2492352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="21797" checksum="6BC3B1189ED0BBD4" modified="2020-06-17" version="1">MMFEVANFFPAGRLQEYQVIGRHLPSEANPAPKLYRMRIFAPNTVVAKSRFWYFLGRLRKIKKANGEIVSLNQIHEKRPQKVKNFGIWIRYDSRSGTHNMYKEYREMSRTEAVDALYQDMAARHRSRFRSIHILKVVEVEKAADIRRPYIKQLLTKDLKFPLPHRVGRSASKKIFTAHRPSTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJF8</accession>
    <name>A0A6A6QJF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_620641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5363079at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="2">
        <location>
            <begin position="1841"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1703"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1993"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
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</entry>
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            <begin position="32"/>
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            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:formation of translation preinitiation complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="1">
        <location>
            <begin position="111"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="29200" checksum="22B4C236325D5FA3" modified="2020-06-17" version="1">MDIPETASLFITIDRTTEDSVGPHVAQLLNLQNAHPISIPEKDVQADSAEIEENACTDVFRHKKKSAKAKTKKSYTLVADFEARLSQVASSTTSKQDVSAGSLLRTEVVPTNFPSPVLTHIGRKKTIFTNIAAVAEALRREEAHLIAFLIWELGTNGKPDDKGKLVIKGIFQQRQVEKVIGRYREVYVTCKSCGVDDTVLTMEDEQLKMPKQPWSGSKFVVIVLADLAGKCNACGSESIVPRIRSGGCRGLTVGHRRTVQELRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMW9</accession>
    <name>A0A6A6QMW9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_52941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="561"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="848" mass="93107" checksum="2C56AC144A0EE5B9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMX7</accession>
    <name>A0A6A6QMX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-(R)-hydroxypropyl-CoM dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_514444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2493093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="277" mass="29391" checksum="4AC737A94D0CCB04" modified="2020-06-17" version="1">MSPHPHPPRLDQKVALVTGSSSGIGRAIAIAYASHETKLVVCADVRPDAHGTASTPEDKETTHELINKRYGEGKAVFVRCDVSEADSWQTAVAEAVDRGGRLDVLVNNAGVGEHNYPRLHLMDEAIWDKTMAVNAKGVFLGCKSALAQFMKQEPHPSGDRGWIVNIASVFGINGFSGGHGPYCASKAACLNLSKSIALDYGPDKIHCNAICPGFTQSAMTEATFKDEAANAGRLAVTPWGRWGRPEEIAAAAVFLASEDSSFITGIGLPIDGGYLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNA0</accession>
    <name>A0A6A6QNA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_563760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNA0"/>
    <dbReference type="OrthoDB" id="10601396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="270" mass="30808" checksum="C645147A9CCF044E" modified="2020-06-17" version="1">MEHSLYEYAVMRLYRELIEDQADSAGYGISTSELNDFLQLLNIGNFEELMGVTTEYYEIFHVLQLDGIDFLLEAPDCILDFELDCYLALSLRSSDHFLGEMFEQVYGSSVEEFLQQVYGSSVGEFLQEMDESEDDGEEDDDEKEDGEVTEGDEEPELESEHDGDNSGLDLFDNNFLVVVQMGFHGSYPPELFASRRGSATVWSLRWEPEESIFEAQIREELRILEAELHNSGLLGAGHRIAMVQRVDGGERYLMSRESVGRFSQPAIQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNF9</accession>
    <name>A0A6A6QNF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_529768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNF9"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="369" mass="41418" checksum="B8DADB7F50C4D31D" modified="2020-06-17" version="1">MAGPVRQPIDISSLEKYIEKNVADIKTPITLKQFGFGQSNPTYQITDARGSKFVMRKKPPGKLVSKSAHKVEREYRIINALQNTDVPVPKTYGLCEDDSVVGTPFYIMEFLDGRIVTEPHFPGVSPEERNEMWHDAVRTLAKLHRLNPASIGLSTFGKPTGFYNRQINTFTQLGDAQSVAKDVETGQAVGKVPRFDELVQYFSDPKSQPKDRGNPIHGDYKIDNLVYHRTEPRVIGILDWEMATIGHPLSDLSNLIVPWTITAFDTSRRNSHPAFHPFNHPAGLPSRAQCISWYRDVAGWDPAPEIAWGTAFAMWRDSVIFQGIAARYAVRQASSEQAKKVGEEMKPAAEICWKLVEQAKEQKSLAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP76</accession>
    <name>A0A6A6QP76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_528124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP76"/>
    <dbReference type="OrthoDB" id="10670141at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="274" mass="30124" checksum="787FC6F2DB18A282" modified="2020-06-17" version="1">MSPGGPPTETEGGDGIGFFALDDLIIDSEELPAGANGGGEGAIRVAQSPARGSADGFVGGWREHQQAAQAVANQRNEGAGGAGANRPTEVVRRAAGETGSVEKGKAPPNRPPSWIWSQADGGYWHRRVFNPKTEAYDRIMERPDERRRRQVQEARERLERREIEARERRMRQEEEARGRQDRLLAQDVVRLLNQRQQAEEAARNAPIDTQLPVVLNPGIVLNAGAEGSNTRAAGKRKRTMVEAGQGTGEVDPHFDLQAENPPRKRRNAPREARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPM9</accession>
    <name>A0A6A6QPM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_466328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPM9"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF10">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="320" mass="34638" checksum="5F61528083F765BA" modified="2020-06-17" version="1">MHIKTIAIVGPRGNVGTALITELLADPTEFTITALTRPNSPYTPQSPDIKVTEVDFTSLDSLIAALSGQDAIAICIPGGAVRLDSQKLLLDAAIAAGVKLFFADEYVSDIRNPAYVAMPAQFVGDKIAVRAMLEERSAKGEISWTALNGGPFFDMWLTKGPAGFDIPNRLARIYGTGDNQACWTPLPVMGRAAANMLRNPDPILNRAVFISGVKGLSQNALLAALEEQVGKFEVTHVDVKKIKLEAEEAGKRGDIGKWMKGMTVNSNFNEEESHSDFWHLVENELVGVEVVSVGEAVKETLERCGRDVKVVEALFRVGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPT2</accession>
    <name>A0A6A6QPT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRC0</accession>
    <name>A0A6A6QRC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_45692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="9">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
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            <location evidence="9">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="entry name" value="TERF2IP_Myb"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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            <end position="465"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="849" mass="97112" checksum="B7CFE992CC7539C7" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2494866.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS39"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2495338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="513" mass="57845" checksum="A9D950A09697073F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS91</accession>
    <name>A0A6A6QS91_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_550706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2495009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="35809" checksum="D64DA35C9D2672C8" modified="2020-06-17" version="1">MSPPIPILDAASMAKGTGEERAAFGHKFLESMTEYGFVKLVNHTVPLPVVEDTFSKGQQRGWSPPGEEKTWWLESNTGDVESPRFSDNKESFDCGDPKDKQFPNQWPTESALPGYQSTMDQFYYDCGQLCVDLLEVLAAQMNLDPKLFSSKCTNEASTIRINHFPPIDRQTLESGQVSRIWPHNDFGIISLVFPDRTGGLEYEDRENPGTFIPMPYSGDDEVVVIISETFQRWTNGAVRPGLHRVTKPVDMVGDVVPERWSLVYFCKADRHINVGPLEEFVGPERQPLYEDLTALEYQAMRNAVHYPEPVAEGVSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSG5</accession>
    <name>A0A6A6QSG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_561391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSG5"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
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    <sequence length="345" mass="39596" checksum="488DDB5B88B024AA" modified="2020-06-17" version="1">MASDDLVWNIIGNQFCSYKVKTTKDQTFCRNEYNVTGLCTKQSCPLSNSRYATLRPHPETGVLYLYIKTVERAHLPNRWWQRIKLSSNYATALAQIDAQLIYWPKFLLHKCKQRLTRLTQVAIRTRKLAREQERLGEKLVPKLAPKVRRREETRERKAEAAAKVERAIERVLVERLRSGAYGDRPLNVEPNVWKKVMKGLERSGEATRDEDLDDGIEEEVEEIEGEYEKELGGGEVEYVSDIEGESDDEYGDMEDFDDWMDGESGDEESSDEDVEDDDESGSASEDDGEDEGEEVEALKKVLGNLKRKRPAAPPPKPKKKPSKGPRREIEYEIEREPASRQVLNA</sequence>
</entry>
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</entry>
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        </location>
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            <begin position="10"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2495083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="677" mass="74038" checksum="62CD95D51B87384D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Lophium mytilinum</name>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="322" mass="35867" checksum="777343111462E58C" modified="2020-06-17" version="1">MIYEIRQAGAKGLGLFATNPIARGTRILSERPLLAIRQDQDVDGIFYAAKSLTKNDKKALLDLSGHSGGQHLELVRWMQVVWWNVKNLVGSVRQPSTITSSIPSIRSMQEHMAIFNVFRSNSFNLGGRGRIQQAVFDNVARINHSCLPNAQGNFHSTLGRFNVHALRDIKSGEEVTLNYLPELGAVAASRGSKLRKGYGFECDCVACDLTSARGKLGEERRAEERKRIKEFAATVEKNAEGLVAELKMTERFIQLFEAEGITGREVASMYFEVAKLNVKLGRRDEAIQCAEKGLELDEYCIGSDHPTYEDGVEFIKALKSKN</sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="209" mass="23662" checksum="E35F06FF964BB3BA" modified="2020-06-17" version="1">MAEATSEPEYDLFPVFCTADIPIDVRLPTSHVLVPKASVRASRQQLPASQRVPNRRPRAKPPPMDPHPLAQSTFDIPTVPPVEPFTSGFIGASFEDLVSFDEKHFLPGYDAQIDVSCFVVMDERTLEDHTVAFYALEFWERREEEEDPDMYEGLDGSVEVEGWKSIRLRIRSASALITWVHDRNISIVEGEVEITEDGIMDDSSVLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QU43_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Putative tetratricopeptide repeat protein 1</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="8"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="29140" checksum="7548B8394AE28388" modified="2020-06-17" version="1">MDTPSETEPSKTRNTLKPEADEEPTSVRFSPEEEASLVAETTTEKTTANALFSKGDFSSAIQGYNKALGVCPTYLDYDVAVLRSNISACHLKLLDWKAAISSATEALEALDRLDPPPKKPKPGDDAAEAVVEEVDDDTASKIEALNRSGRSRDDIQKLRAKALLRRAKARQETGGWASLQGADEDYKVLAAMPNLTPLDRRTVQDALRTLPPRLEEAKQKEMGEMMGKLKQLGNGILKPFGLSTDNFNFVKDESSGGYSMNFDQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QUE5_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">BU16DRAFT_538400</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUE5"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="192"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="415" mass="47393" checksum="A519D2C8DBE271BA" modified="2020-06-17" version="1">MSADVSSHRQRSDTFPGLPLLSASAELGCDLCALLKESTLKWLDEHFEHAEKVQIEWLGCEDINMFVKHQLCGALLGSGFCAYIRILGPYVPKESSNWYRVQKARLTQTLANQLEFEIVGESGNVEDASSPAILSSIKDWISACKQPEEGIRKDASRPTRLLDMDSNWSQGSISGVRLVDMTYSEDAEINHYVALSYCWGGSESKHPPKTKRGNLHSRASGIPWHTLPLAFQQVVSLLRKLDYRYLWIDSLCIVQDDEVDCKTEVASMKDVYRNADLVVALARISNCHEGFLEREVPRVAKIPYVSSQHAIKGHVYLRPQSSFAVQQQKEVDQSEWNKRGWTFQERFLARRALIFTKSTVHFESIRSVRCDYRLDEMRHAGESLQSNHRWDREVEPPPANSDEDIPEFYVSQPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUI5</accession>
    <name>A0A6A6QUI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_485509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUI5"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="359"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="480" mass="53241" checksum="68829B6938D247C3" modified="2020-06-17" version="1">MSLDPPTYILSLQNNIRARPISWEGAVRAKTITDADLKKIKSIDKVRKEQRKQTIEGDIDSFCSLLLGSPGSPSIFEAAAKRPDIIQYMLVLTGDIIDDIPSFTATLAKHPAPFQPFLPLLKASTNPEDALPLLTSAVLASLLGYALTLPSKDTTQIDEALPKLYSYLSALAKSSDAGLQDIAVQEYSVVLRTKKSREIFWKQREETLNPLIDILRAAAGAGKDTDSTLWSGGASVRSAPEGGLAGGVGLQLLYHVLLVVWQLSFEGTLVGDGLHDEHDIIILYVQLLRLSPKEKTTRLLLSTLSNLLSSNQRNLLPAAVLARLPALLTNIQGRHLSDPDAAEDLKSLIDMLDDYTKTQTTFDEYAAELRSGHLRWSPPHRNPTFWADNARRILEENKGELPRKLAEILSKKWESDKQVLAIGCNDVACLVKEVPEKRAMLEKLGLKGRVMELMQEADETVRWESLRAVGEWLRYSFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUP4</accession>
    <name>A0A6A6QUP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_617623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUP4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="465"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="864"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2496131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="989" mass="108619" checksum="82CB8E1BB51A8EE8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVD4</accession>
    <name>A0A6A6QVD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_508525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVD4"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="509" mass="56004" checksum="95F3B99EA08A8EDB" modified="2020-06-17" version="1">MPFTTAKKQIYLNFFEHGCTGSHMSPGQWRDPSDKGTTKDTLDYWINLAKLAEEGKINFIFFADGYTTHEIYEGTSDPMLRAGTQFATIDPMTVIPAMAAVTKTLGFGVTGSTSYLTPFILGRTFSSLDHLTKGRIAWNVVTSWSKSTAQALGAEDVIPHDERYAMAHEYMDIVYKLWESSWADDSVVWDRERRVAFEPSKVKRIEHQGKYFKMSARGNTHPSPQRTPVIFQAGTSTAGRAFASKHAEAIYVGGLVPAQTKGRIAAIRAAAAERGRDPASLKFFVGISPILGATLEEAQAKYERAKENADVIGGLAQFSGYTGIDLSRFPLDKVFELKDAPGDDAVHSFLENFNNVSGNTEPWTPRRLGEKMALGGFHPAPVGTPAMVADVFEQWIDEADVDGFNIAYITTPGSFEDIVYLLRPELVKRGLMWEDYTVPGGSLRENLTGVKGQKGISSDHYAAKFKYGRGFEGDSIEAMKAVKPKTNGVSIKLPVLNDKLPAAREEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVT4</accession>
    <name>A0A6A6QVT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_462210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVT4"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="71"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="496" mass="56730" checksum="4D7624C33D4CB879" modified="2020-06-17" version="1" fragment="single">TESVLAWPVFGPVFASIRKTPFLDQNGQRQNAYLCDWGEVIEASPGTLTRSSAELRPLQLSTDREDVDPLIRRFFRNVNTKNPILDYQTVNLHCHAIYENGPMWNTSTCLVFLCCALGAASQEWHYQELDASLFEHETTTSYHEDGQGDLQLAHTYFSAAEKRLGFALTNPDSLSVQCFCLAGIYSMYILDPLAALRMFTAGGSTIQLLLSKSSSNLNITDSSSLVQRLFWTCLKSEREILAEIPISHLSIANLVMLEYYPSPPNSQGESSIRSPWKNLEEDSWYYYLSEIALRRIADGIIIAMYPEANLPEQSFGTQYMQKLASARELETQLQSWIMSLPQCMSFPVGWEPVDKELQYFLRSRFYLVSELLYRPFLEVWIRTEQPNLEDVIDNARKALSYGFSYLMHSNHSHRHHGKWLQLRRETTFACTLLISAREQNMRGIDLLPSNWQIGVARALEHLRLWSKERPALQSYIDVIMGVHDCVHRDGQSVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW00</accession>
    <name>A0A6A6QW00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW00"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="19631" checksum="D6A827684592A680" modified="2020-06-17" version="1">MGFSSFGNQVKKRKYNHNDTFTGDSAEKESSSGANTIQLGVRHKKRSPDAPDQGEDAPNPKTTHPDFTISDAKAKARGKGKGKEEASSGLAAFLQRAKEIPDRAPPAMREYVLPTGNAVSVPSLQPNASLPAKPPTSIPEEQGSGSGGNDLHRLAKGVKNARGDTFYFLPSFIEDPWKGLEGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW42</accession>
    <name>A0A6A6QW42_9PEZI</name>
    <protein>
        <submittedName>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="39918" checksum="9AE91895E46A3DD6" modified="2020-06-17" version="1">MDQTKAGSSPESRQNATETPSIMDQTKAGSSAESRQNATETPSIMDQTKAGSSAESRQNAATTPSIMDQTKADSSAASRQNAPPIPVLLADLPAPTPQDSLTGGKSEDEEQPDFSPCEVVLSGMAAFSIPGSYLFLKQHTNLSMVESKLQEGQYERPVDFFKDMTLTFDQLFKAFLPEQLVFVLGRYFHALFTLLWSAIIRSLDDSRKASQPTEAERPRKKMKMAKEGTEAGDRGAINQLESAPHRGQDQELFEGLLDLSQVGEGLLPYPFEVRADSPRAKPKKSLIVKKLEFLESWRENLDFCNQTSSLYEKADQMNVAILERFEAGPVQKEVETKLKVHFDRRKKELGGSWGTPRYQ</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        <source>
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        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
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    </reference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="51527" checksum="F745A76C2BCD5A0D" modified="2020-06-17" version="1">MERRVVRKFDRHIIPLVMALYLLAFLDRSNIGNARIAGMSTDLNLTGDKYDWLLTIFYIPYIIFEFLAMMWKIVPPHMWCAFVVFGWGLVSTLQASVHSWGGEMTLRFFMGATEAGYGPGIPYLLSFFYLRHEVGFRCGIFLAAAPLANTFAGALAYGITSGHSAIANWRVLFLVEGLPTIVMAAVAFFFLPDSPEKARFLTEDEKRVAKARGVSQVGSTERIGGIVWSDIGAVLLDPKAWFTGLMYFSCNVSFSSLPVFLPTILKEMGFSSVNAQGLTAPPFFVSFLLTVGTTYIADRTQQRGYVLMVLTVVGGIGYVILATAHNVGARYFGVFLAAAGIFPAIANILPWVLNNQGSDTRRGAGIVLLNLIGQCGPLLGTRLYPSNEGPFYVKGQAVCAAFMFFTTLLVISLRTLLVWENRKLDRQFGTLEEQRAATEMAVRNEDSKAGADEGAGLENYGPSFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYR8</accession>
    <name>A0A6A6QYR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_482689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYR8"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="104"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="594" mass="64176" checksum="EB5EEBA2C323F468" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYW1</accession>
    <name>A0A6A6QYW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="5">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="5">EF-G2mt</shortName>
            <shortName evidence="5">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MEF2</name>
        <name evidence="8" type="ORF">BU16DRAFT_525121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="38"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="884" mass="96393" checksum="5177C6A32CA3EA24" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ91</accession>
    <name>A0A6A6QZ91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_537074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ91"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="17192" checksum="92109699C401C444" modified="2020-06-17" version="1">MHYYQLPHSIFFHQTSSGSADTSGGPPASLDAVIVVNAAGVHEFEEYVSGLKRRGRVMVRETNLHQPHGNGLEIARRLDPARGRAFVTAMSWVEGEFGCVSRAKSQGALIGRATLFGPEQLFERAAPMHQRFAAATYNLAPIMQVARDTQGSPQSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZC2</accession>
    <name>A0A6A6QZC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_314341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZC2"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="192"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2497442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="365" mass="39295" checksum="4E8E7F29C8C5E154" modified="2020-06-17" version="1">MPYPETTTAFVVTDIKDGNWTKFSKQELKLKPFESHDIDIAIDACGVCASDVHTITGGWGSEIPLPLCVGHEVIGRAVKVGDAVKGVKVGDRVGVGAQIGADLTCNNCKADQENYCPNSIDTYGAPYPDGTISQGGYSSHIRAHEYFTFKIPDGLDTNLAAPMLCAGLTTYSPLVRLGCGPGKKVGIVGLGGLGHFAVLWAVALGAEVTVISHSPSKKEDALKLGAKHFISTKDDKWAEPHKFSLDFIVNCADATDKFNLSDYFSTLKVNGTFHMVGFPDNPLPSIMAQDFAPNGCYIGASHIGNRPEMEAMLELAAKQKIKSWVQTIDISEAGCKEAVERVYKNDNVKFRLTLTGFDKAFGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZF8</accession>
    <name>A0A6A6QZF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2497868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
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        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636">
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    </dbReference>
    <dbReference type="Pfam" id="PF08560">
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    </feature>
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            <begin position="109"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="18201" checksum="EAE9062C0AACB570" modified="2020-06-17" version="1">MTSLFPHPAYAEEQPHARTILYLHVIRAGTQAAALVATVTATASSLYYRPRSLAAFVPRLIIHSARAVPIGIVFSGLATAGRMYGREQIEWQDRTWRLLENKPQERADWWAIGGGVGGAVAGVWGVRRGVLPGVVRGRYLGRTAKLVLGGAGVGMGPVGVGLGQVYTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </gene>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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            <begin position="20"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10402634at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="149" mass="16480" checksum="DAAC3B9E31FC40ED" modified="2020-06-17" version="1">MTADNFTLEAKILRENNEKLDSNIPLSSAAAHIPTIQVRPFNDTNYVLKPSLKATTPPTYPAITSTNDPASDPISSNVPRPTHNAFSPLTESNLSAHDSSPHRNASRSDRDRRDRLKNAGTELGFELTDHDIPPLHEGKTPMQVWMAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0N7</accession>
    <name>A0A6A6R0N7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_605792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2497413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="330"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="609"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2P2</accession>
    <name>A0A6A6R2P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_482164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2P2"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2498995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="411" mass="45949" checksum="6C596EED8960091A" modified="2020-06-17" version="1">MQKIVAGDRFPMLSPMAGSNNPVRESPQPAQHGEFGDGADASRGIAPIGRNITQRDVYESRYSGHLLVLGQYMQQVRTQHPDWTPEQVQKQATHMVQKTVKAARNLAMSAAIQSNHISWPLASLASSSSIRAGDKQKGLKQHDQSGLRLVLGKRSRFELADVLSRDESRLRSMTPLQTSVVNMKDRSPEGPGMDFNLVPPGLSADSQEQLMSLLSKPLRLSHPYQRPFGGHLPLGPIFSNVNSPNGQLALGGHRSPSPQLKNDRPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCDHCDKSFSRRDALERHILVRGCGKVYPDSNNDRLNNQGEGCYDKILHRTPLDRTSIATKGAQEMRKGEDGPSALFMKYTISQDITRTDHAHQKGLFLAIKDRRTSRDRRALRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2V0</accession>
    <name>A0A6A6R2V0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="7" type="ORF">BU16DRAFT_524703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2V0"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="340" mass="37744" checksum="5B34E33AA1A11C33" modified="2020-06-17" version="1">MPLVNYSDSEDESNGTPADLQHQNDTNALKRTRDEAEAPSELPPLPSAFYDLYATDTRRSTRDDSSLHGGRKRAIPHKEGNWLTHVYLEWHPTLTESTTLSTLISLVQKAEHAQELSDSDPGIHSSLLSPLGTPLPLHISLSRSLVLVATQRESLLATLTTNIRKAAVRPFDTEATALKWVPNYERTRWFLVLGLAQPEGDELNKLLDACNATAVEFRQPELYSGSGSSENIKDEIENAEGRKHRKKRRRSRRSTSSTKVEAPQDRSEAFHISIAWTLEDPGTAYTDLLQGPDVEAFLDKEVRAMKVRLEGVKVKIGNAVSLVPLAPAKKLDDSHGMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R334</accession>
    <name>A0A6A6R334_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_309958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R334"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18541" checksum="132325E6E84C1616" modified="2020-06-17" version="1">MTKDHYITVTASTPTSTPTDSLQVFKSSESSSSSGMTVGAKIGVGIGVPVAALALGLLGVFVWFRAVKRHRSKTPEMKPPWGVDAQESHLTPEEYERTKNQKPPEDDEVHATYDGEPDGPNAPPRSSFLQVSPLSRNRDSMATSSVNTTSPSVNYTPIPFNDLPELVDGPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R340</accession>
    <name>A0A6A6R340_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RBP11-like subunits of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_454793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R340"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="149" mass="16593" checksum="7D789B662962F066" modified="2020-06-17" version="1">MAPFQPGVHANENTLNEVGSIDIPDRFETFLLAEGEKKVEQKEETRIPNTVTFTFNKEDHTLGNLITARLLKDDRVTFAAYKVPHPLFAMFELRVSTDGSITPKNAVVKACQGAIQDLDVLARSFTTEYLGKKIVREGEAERAARENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3K5</accession>
    <name>A0A6A6R3K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiolase-like protein type 1 additional C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_481187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3K5"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="420"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="519" mass="56525" checksum="EC7B9250A64466C9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R444</accession>
    <name>A0A6A6R444_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12/S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_524627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="145" mass="15926" checksum="5D5E0E4E3A699341" modified="2020-06-17" version="1">MGKGKPRGLNAARKLRNHRRENRWSDLSFKKRLLGTAYKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLSALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4R1</accession>
    <name>A0A6A6R4R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4R1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="297" mass="34200" checksum="5BF82E3844E9B34A" modified="2020-06-17" version="1">MNTTWDPSRFILSNHITENVEEHHSSFFPIFEGDEMETPSSTLEVGYGLDHNPSDHERYVNTDIVPRSTPPPYAEQDDYPFLEELALHRQQEQPPSRPTTPLPAYEPFEFKPPEYDTPSGHYVHQGVWYCCRCQLSVGNSLRETELGLYDYATCGCGHRSCSSCIWDKTAFQPVPWHIAKKIKGLGFSRGMPYVVICPRCTFFCGAHFLQPPMSRRSRLKKAVLEGLLPVYNWAYYRPAWGRNLPSRYRACKCGVRFTHEWLCFRNPEGRFDPVGTSLRVLEILEDGMPEGERVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4S9</accession>
    <name>A0A6A6R4S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4S9"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="42006" checksum="9B2F8086AF84E70C" modified="2020-06-17" version="1">MKASLLLSVGATILVPVILGTPIGGLISPAIIFPKKWASLGDSWASGVTWFKEIVYDDDHDKVIQCRRSKEAYAYQLSQNDTFLPVKDQVFNWPACSGVNFEHMEGQASEMDDGTLFATMTVGGNACGWDPLVTACVFVPDPQQTRCSPEYPDPASECYQKMVESRDALNNEENFLARYVDVLGKVMKIGKEKHGSFQLYATNYAHPFNIDPNWCDEESFGMFWCRPKLTALLRHDINDLAELLKQKIIKDVQQFRKQNHDGKSVHFVEISDCFNGHRFCENDHDITDQWDDTYTGGKTWIYLPPRPPWNDLWKDIDAWVKKYPDNNITTEGGGSAPDRPGIIMKTFHPKTLGFGTMADNIRKAVYDTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R507</accession>
    <name>A0A6A6R507_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_557943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R507"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="465"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="31748" checksum="529D186EE85CB550" modified="2020-06-17" version="1">MAPHSPSAAAHSPLAEAQDTNETLHCLSIVELLAQVFLGLPMVDIIRCKSVCRQWSDVIDSTSSLQRVLWMSSPSVSEPFDPTRYTFENGKIRAFQDGIVFIGIESCSLVQPKKHPFHALPEPAMFLRVNPLVNRNITEEITDGTITRHYKYVANERPYRTIRSKRIGMINRNVGIEVDSTKEDFPYRWFSNIIKLHFSPPRCENIQQSWMSMFLTDPPCSDIIVKAKVSSGGEFRIPISRAHGIRTGDIVRAIQVHKKYFDWDAEDILFEMRFDAHA</sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 269.34</strain>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAC5"/>
    <dbReference type="OrthoDB" id="10524191at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025476309" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="39903" checksum="4D48E50481BEB673" modified="2020-06-17" version="1">MFFRAAVGVPLLLSSLASAALNGTYPASTTTNLNCATKMGKHSACPVPTCTKLWTVEAPPVIIPSYTQMTLTYTGNASTITSTETVQVTATVTDSTITDTFSTTSTEYDTITETISTTTTFTETDTATTTSTYTSSVPTASGFVPVSDTLNGYPGSQSQKRNDWSQLEARAANSTECGVPKDDYPQSVECLAEIMVQSTKLVTVTQSPTVTIITPAPSSTTVQSTTTSTSTIVPDDVSTTESFSTTETMTETATLSFTETATTTTTVEAAAATTVIAACAADNIVGPIDGRSIYNVFNIGPNAATIYDNAAATSAYDCCAQCFNKDGCTGSIYGYGRCLLMHNSARTCDSQSANVAYFVAQTGSGGYAVSNGNCGYLYDHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCT9</accession>
    <name>A0A6A6RCT9_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_522511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="426718at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01764">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5025535250" evidence="3">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="34139" checksum="FB1FC946DAE44F5D" modified="2020-06-17" version="1">MRSFLSLSFLIALLAGEGSYAAPLAGLTGRSISTDMFSTLQLMEQYAAASYCSPNYDETPNTEVTCPAGNCPLVQAASTNTLVEFENSLKTDVTGFVAVDHTNSITVVSFRGSASIKNWIANLDMTQITTDICKGCKVHQGFWDSWTEARDGVLNAIKSAAASNPSYKIVVVGHSLGGAISALAAAELRKSGCDVALYTFGSPRVGNGAFSDFVSSQSGGNYRITHYNDIVPRVPTLVQGYVHITPEYYINKPNFKAVAVSDIKEYKTNTIFGGNNAWVVTDILAHTWYFNSIAQCYINSLLPKRDLDVEVVERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD42</accession>
    <name>A0A6A6RD42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_4549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD42"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="344"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="586"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="688" mass="74507" checksum="5B999364B1F63463" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFF5</accession>
    <name>A0A6A6RFF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="274" mass="29896" checksum="80B8EF79B202B19C" modified="2020-06-17" version="1">MQRCQCEHEAPGTANGRPCLVWNAVAEAGRKRSMQGSSEVTSVVWHEAGRKERQIKGAWGPWPGGERRKKRTKERRAVEELRGTVEEVAETAEGVQDPRRLHGARADLLATERRSFTAAIPDAAAAMPHPPASIPNIPAQGPLGSAGNRPPDALAITPASTGHSTPSLLASHRLASPSAWSLLRYSPLRCQLLPGPSWLEPAESETQAMDAIDPSWRLFVQRACITGPFFMRSTCPKHPTSPVSLHQNATLPSFLNPIRPGLRLRPMHLSRPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFN2</accession>
    <name>A0A6A6RFN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_33424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22898" checksum="41E284D40D84485C" modified="2020-06-17" version="1">MQRPRNRQPRDSNSSSRGRQNPRGGGRPSHHHPPRSYNSSSSVPSFSALAAGTPVSIVLKIDQPTGHQVRGIVADLLTRGDHPRGVKVRLRDGRVGRVQGLVSVTEGEAGEAIVGGVGAKLGRDGENDRISGRGGQFKYTDVREEEDGEHEERVSSLADYCPQLAQLEQRENLQVERGNLGVESVTATCPVCGEFEGDEVAVAHHVEEHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIV4</accession>
    <name>A0A6A6RIV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_533523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
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    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="81"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="476"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="599" mass="63496" checksum="61CCA6C249C54DCF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q800</accession>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q800"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="475"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="834" mass="92232" checksum="B01DDE35485E10A0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA81</accession>
    <name>A0A6A6QA81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_575612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA81"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2489142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="237" mass="25898" checksum="E963ABB81B2ABA45" modified="2020-06-17" version="1">MSNPPTTPLPAHKLTFLQSCLSANALKFGTFTLKSGRTSPYFFNAGLFHEGHLLRSISTAFAETIHNSPLCRATGEVGFDILFGPAYKGIPLAATTLLKLCDRSEARYGALSYSFNRKEAKDHGEGGNIVGAPLKNKRVVIIDDVITAGTAIREAIEIIKVQGGKLVGIVVAFDRMERVGDGEAQRGSAIGEVRRQYGVPVLSILSLDDVVEFLRGLGGEEDLRRLQEYRERYQARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA92</accession>
    <name>A0A6A6QA92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_622809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA92"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="102" mass="12111" checksum="F9CA7965578CD397" modified="2020-06-17" version="1">MPLELNTIKDSLQQFEQLSEDATQTQDELGQLQIANNKWREEFELARSTRGDLSDVEQEVDKLGKKFNHIKERQRQILEECRQIVDRLRELTTLEEELVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAE1</accession>
    <name>A0A6A6QAE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter-like protein Ptr2</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="179"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="662" mass="73362" checksum="98FF4C469A46FA6A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB03</accession>
    <name>A0A6A6QB03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BU16DRAFT_568168</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB03"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025603001" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2488647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="323" mass="34450" checksum="6A4F6DACC29C5E25" modified="2020-06-17" version="1">MRLSSTLLGVAAVLGAAEAQLRGFNYGANFLNNQAKVQADFEYEFNKAKSLPGTSGWTSARLYTTIQHGTTKDPISAIPAAINTKTKLLLGLWASGTTAAAGQANINNEIAALKSAIAKYGTKFTDLVVGISVGSEDLYRITPTGIKNKAGAGAQPADLIKYVKQLRAAIKGTKLASTPVGHVDTWTVYPNATNAAFISNLDFLGVDAYPYFQTTMANSIGHANATFYDAYNQVKNVKAAKGKAIWITETGWPVSGPKQNQAVASAANARIYWQDVACSLLAKKVNLFWYDLQEAQYGNPSPDFGIFGAGDLGTLKPRYSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB36</accession>
    <name>A0A6A6QB36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_567384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB36"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="262" mass="30060" checksum="63CC0B7461DC0FE7" modified="2020-06-17" version="1">MPPLKDRILQRLHLAKAIWDSLRVASHPTHLIRIVVSNPVELRGINAENVAEHGWAMPTDLSPDDKAAILTYGGCDQSCFIFMKLLPYMLGEDWQEISWYCIDPVPSRNVWVGTEQENLDNAQSEFFHSYLRLVLNDSTVFAVDFTPEQFGWPFEVMEAGKYDRKYSAPATSPQRVDWLREEAEMPPETFDKLLRDSLLSSVLRLCGHVKPTDDLFAGMFEQSIAKSDETQRALLEEIGQDIRDFCQSFDKERCSVPICQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBE3</accession>
    <name>A0A6A6QBE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_623072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBE3"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43192" checksum="9840D2298075C8E7" modified="2020-06-17" version="1">MSLLGSPIVKVRDHGAVIVLTPFRLLDLPRERRNRVYYYVAEGGIFIKDLWISQFFESGLSAHPKYRVHDVGRRPSRTSILLANRQIYKEASETLFSQVNFTFVAYDSGPKLPMRYLRSPHLLFDKRMTLIRSIELVLFDGFLDSGLCSSPLIEWNNFFLGLRSLPNLRYLGLDFREYAALSTRDTDGHRRRDRTTLIKSLLALSLSDERICQLDELKLRFEILDTPEWSLDDEKPRITAWMRGLICALLKNGSKVQSPEIGYAKSEYRTPYQHACRCSSCDAGVGIVAACHVKNNGRSILTCSDMFNPKTERWLLRESRDDILKHSCQYAAARARYQRIVFLDHHASRTEDFAYEREAQFPRKIKNALEAIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD54</accession>
    <name>A0A6A6QD54_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_622573</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD54"/>
    <dbReference type="OrthoDB" id="3935502at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025689213" description="CBM-cenC domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="80359" checksum="13A1D66F12152490" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDW9</accession>
    <name>A0A6A6QDW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_596107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDW9"/>
    <dbReference type="OrthoDB" id="3546897at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="594" mass="64808" checksum="9AE33466337DE090" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE93</accession>
    <name>A0A6A6QE93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_530919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2490429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="102" mass="11243" checksum="4F50C9D2FEA96203" modified="2020-06-17" version="1">MADQLLETLRDAVEGQIDFEGQRLAELVTTVLLGVSGLIAFFVGYVQQDIYQTLWIGLGGTALTFIAVVPPWPFYNKNPVDWLPPHNSIADLRIDVDGNQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF87</accession>
    <name>A0A6A6QF87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_469843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF87"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26526" checksum="5483BF56604C5EC3" modified="2020-06-17" version="1" fragment="single">ATRWRAKAPLSYATIRERAISQRMYVIDRTRKGTAEAPEEHVDIAGTTGNIYTVSIKLVPDCTCPHAKKGNQCKHIVYVLSQVLKVTGDLEYQVAFVSSELREILEKAPPIPTEDASSDDSDGKRKPIEDDCPICCMEFEVGKEEIVYCKAACGNNIHKHCFEQWAAAKSGARGGVTCPFCRTPWAGDEDMVKKLSKNGKVNEDGYVNVASQLGLSGERDYSTYHPFWVQRQARYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFE5</accession>
    <name>A0A6A6QFE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial folate transporter-like protein/carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_132704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFE5"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="239"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2490720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="41922" checksum="7232F879E580D4FF" modified="2020-06-17" version="1">MSAKDRPSPPSPRHSQQRLAVFCAGLSSSSINGFCGASAGVASGIVTCPLDVIKTRLQAQGSFRPRSNVRQTRAIYNGLLGTARVIWKEDGVRGMYRGLGPMLLGYLPTWAVYMSVYDASKDYLYERIENKWVARITASITAGACSTLATNPIWVIKTRLMSQVSSRASEEHRPPWQYKGTMDAFRKMYKSEGLAAFYSGLSPALLGLTHVAIQFPLYEFFKMKFTGLEMGQASKEEDIHWIGILGATFLSKICATSATYPHEVLRTRLQTQQRSLPTASPEEIAFRGGHAHGYQTRPPGTASSDGMVNALRYRGVIRTCRTILAEEGWRAFYNGMGTNMVRAVPAAMTTMLTYESLKQATFELKREGQEILDLDRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFU7</accession>
    <name>A0A6A6QFU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_516805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
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        <source>
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        <source>
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    </evidence>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
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                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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            <dbReference type="EMBL" id="KAF2492238.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="506" mass="54818" checksum="BE37D4A8A3D74C6D" modified="2020-06-17" version="1">MVLHGKKIYNNALLAGGLSFITFGWDAGVLGGILLTPEFQMAMGMPNTTTISMITSVFLLASWLGCIIVSLSGLFLGRRTWIILGSAVQILGTIISASSYSYGQLIAGRVLIGIGNGFCTSMVPIFVAEMAIITSKRGQGVNAMLACASLGTAFAYWVDFGMVFAHNTQAVWRFPVAFQIVWALLTIGFLLRSPDTPRYLYARDRDVDGDALLERLYEKPINDAEVALAKQDILASLELERTTTAGLRIKDFFWDTSDLQAARRIRTGMILIGVAYLMGIDMIFYYTTTIFQVYIGLAPLTASGLAGAATSVLAITNFVGVVYMEKFKRRTWLISGAIGQTVFLAAFTGLLSSPGHATGAAAAAMLFCWIAIFGPTWCPVTYVYASEIMPLRYRHVGFALSVSSQWLMAFVTVYAGPIAIADPNVGWKTWIWFLVFNAIAAPYVYFCCPETRGLTLEGIDLIFMSASMHDTPAAKQLDHDFAAESTGADTDSGKEGSVAVAPEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ77</accession>
    <name>A0A6A6QJ77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_515900</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="68769" checksum="38861861EA88E1B4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJA9</accession>
    <name>A0A6A6QJA9_9PEZI</name>
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        <recommendedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUDT19"/>
    </dbReference>
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        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="40921" checksum="3B1A187EC1E980E1" modified="2020-06-17" version="1">MSARNLPQTLLHTSIGRPRVLVPYKFLSLRLNPSEVRTYISLLPPHTRGAVAFKNCPQRRFHTYQRAMSRPEDHQPLKNPPKVPRAPIPSSSVLVVSPSNQILLLHRVRTSSAFPSAHVFPGGALSAEHDGEIPAVDSLARHEDGRAYRLSAIRETFEESGILLAKNKTTGRLFTEIGDKEREEGRKAVHGGKVMFLDWLEKVGAAPDTDALIPLTRWITPNNVPKRFTTQMYLYFLPLPSSPSSSPSSPLPPSTTAAPHNLLDPDETIIPTPTHDGGIEHTAARFLPAAKWLALARAARILLFPPQFFLLHLLAPYLARSSTSPTSPLPPPAELQAERDALLAFLRTPATNDGEVEVLRREEVLGKGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKB6</accession>
    <name>A0A6A6QKB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKB6"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="489" mass="55092" checksum="FBA8F9891C21E6FE" modified="2020-06-17" version="1">MASPYSSTQNTLRPIQDDSQPLHKSTEQPYPPRSSQDQWSQSSHWETAGYVPAQTQYHPAPSFDNYTVNQPQSRGDAPYPGYAQITQPTYTEQLFYPPNSHYTPQLYSQQGSFESVPASSYNQAGSQYGGNLTYHSRPAWPAPGPLPESPHQLYSHNHLTSPPASTQPLPLPSPRPPPQARPENLPRPLTAISVADYFHQHACVPIPWRWEPLSTPIKTYYIEAGPAFLDSKDWLGDWVDQEFHTVCLRDRKKPKDRHSMKYHLTAESTGGHFRPEKFKWKLSNSPAGKSRGTLWTYCREKDAGAPPGQVRFEGLYDLDGNRVLTSFKHKDPSHVVPVDTLSFQLPNGEEFQWRSNHPISTLDGYRWDYQRHALFRLSRGVAEELIADNAPWDGRGKKPLDSADALTIRAQNVDHSMVIATLQTMKVRQWEDVLRVEALNDKEGVKKTVKQARKTELGIAYWTQDDFTGGTAAIGFELGSGIVSGLFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKZ3</accession>
    <name>A0A6A6QKZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_87463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKZ3"/>
    <dbReference type="OrthoDB" id="10575964at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="363"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="453" mass="50367" checksum="9D07E4AAD2683C80" modified="2020-06-17" version="1">MGVEVSIESEERPSERVTKIGLQHGEIKLPLFELHGGSTPSRLVTSATRTTGLSSGPTGLSSGPTGLSSGPTGLSSGPTGLSSGRIWAFNGTPPEIPDPPTPEGWQRENTPPRINFDPGTRQDSFKVTVTCFKRQATNGELDDGLTYARISFESWDLYPKFPKLKEQSDSGCQKSKFIRQVLRRDLIYRNWKYYDLCPRDARPHEVYIQLLLESVPIIDGNSTSSTASGYGPCCGDLSIYCSHHVPQTRFKGPIGHDTRVTDPTGKMWGHRKFEVEYCPHAPAHGYARSPDFSPPTPAPPMDIITDKRFEKAREWMKECNDSKAHELCRMRSDFDPARMIDISVGNGSLQIAERLEGRSGKPYAAFSYCWGLPESDNVGRPTYVTTRQNLARRRLGFFANELPKTIRDAIQLARALGFDRIWVDSLASSRILIAIGAKKLLKCRESMAALISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLU0</accession>
    <name>A0A6A6QLU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_551226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLU0"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="35868" checksum="45F91F28367378EB" modified="2020-06-17" version="1">MADNKTEEITLLQLIALNDSCPYDTPFFDPLYRLYLPNDDRPHGFLVPGVVEKTPWTSDFQITHERPRRVDVLDSSDGKATSAACNEAFAKLVAACQEKDLFNLKGEEYEEFAIVGVEYPARLFRYAAPLFGIVSQGAHLTAYTRTSSGLKIWVPRRSPTISTYPNKLDSTVAGGISAKDTPFETIIREADEEASLPEDLVRRDIRSAGVLTYITLLEQGQGEVGGLVKPDMVHVYDMEVTEDVIPKPHDDEVKEFYLMTPDEVKMALLRKEFKTNSAAVMIDFFIRHGIITADDERDYPEMNMRLHRTLPFATAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMI7</accession>
    <name>A0A6A6QMI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_81017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMI7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="68" mass="7438" checksum="0F7D490DA5DDE145" modified="2020-06-17" version="1">MHLETLRGPAEVNFRLFNWTPAGPRVECSSDGGAWLIDPLLYSRTRFIRSNARGLGAGGALVDPARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QML4</accession>
    <name>A0A6A6QML4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QML4"/>
    <dbReference type="OrthoDB" id="3909783at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="280" mass="31343" checksum="32C8B249EEC5B95D" modified="2020-06-17" version="1">MSLVRTNHHCKLADDPDLTGPGVRLSVVIPVLLILALSFIWTIPRARTKRSTIAKIEDAVSKLNALQVAAAIVMLSIALSKRESKDWFHVHFILNTAGLSGWSTVLTAIVVPDYFTETVFQIPVIVAYFVLAILVMVDYQTQLTSAIAEKPECYPQSLAHERYWPMWILWTVGISLCIAVSVCNRESWSPAQRRYWNFDIKTWRTLPILVLLAIPTIGIGAGLYVSFWIYPWLEPLLAQSEDAWTVGQIMPLGFVVAGSVATLWQAFGLDGMVTLSLQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNG5</accession>
    <name>A0A6A6QNG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_541330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNG5"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="205"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2493669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="408" mass="44803" checksum="E0E7862E4D2E38F8" modified="2020-06-17" version="1">MTASQTAQHGIFHGHVDAQKLGVTPKKGRLVPLRTRDEIRAATELLDAYVVEVPAVFASAVLNVIRIAIPNIRDVNIQHLRRVVHLSFLPEHLQQTFIASAQTWPSPEHPDGEARASDPNPTEIRYLLVSPASLIASQDLVAALAREPPFSIANIVPHVITIPVPALAPTSAEEAQQWSEKYWSISYKNTNPYGPHPSLLERNQAGIEPYAGTWLALAKVAGGQMSGRGIGANVGCAIVHKERKEHRVIAVAGDARWRGTGDSKPCREEPGNVMAHAAMRAIGMVARKRVRLEQSLDELTSDAAGQIACDVPLSPVENSFFSVDNLPSTGYLCLDLDIYLTHEPCVMCSMAILHSRFRRCVFENAVKATGGLMTSKESPSVENGLGYGIFWRPAELNWKFLAWHWENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNU6</accession>
    <name>A0A6A6QNU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_528321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNU6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="10286" checksum="3B7BF9D17D0147C9" modified="2020-06-17" version="1">MLRCPYLLWYSTGARAHLKFSLLGMRPWQSSYLFVMVPLHRINAHLLSWLSPQFDSALRVALLFSASTLAMVSTTKSRHSIRPFHAAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP58</accession>
    <name>A0A6A6QP58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_540337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP58"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="47962" checksum="94AC406F37BA259E" modified="2020-06-17" version="1">MSSIPFTPLTQTAGIEALLHMLRLQPTIESNIPSDVVFVSIDIESASWLPKSHAKQGCITEIGVAVLDTRAIRETDPGPGGSNWLQFITAKHYQTRETARLSTRKLDRHGAPLWAGDKFEFGRSIQMPKHDLKDTIVNDLRIPDEERSVEDGAESSSMTSSCSRYRDVVLVTHAWENEDAYLREQLSFSYTEVGTISGILDTQILERFGPRPGLLTLMGKYGILPLHRHNGGNDSVYTLAVLIARGVSCHLARNGQSTGDHRGAEECLLKLKETIAATIGRCNHCQRYGHRISQCAEWLLTEDGKSVALKQNKGDKVLLLKTEDVELLGGRSGRAVSTIPCKRPIRLMADLGDELQFPSLRDASGSSGSSTSSRSLESQPAATKADNTNTEPSVPGRPTEAIEPSEQVREEPSASEKVTHAKKGRKKTTYVPLRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPE8</accession>
    <name>A0A6A6QPE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_513599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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            <end position="1013"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1306" mass="144032" checksum="3B39C62DBB9D9022" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ35</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="125" mass="13687" checksum="E17AEA96D89EBF02" modified="2020-06-17" version="1">MASLNVFRKPLYLHSTQPMTGFTRNGYCEVPPSDSGNHSVAAVLSDEFLDYSASQGNDLRSIGLKGGCKWCVCATRWKEALVASKGGKGVGEEVVPKVYLNMTNEKALEKISLEDLKRFAVDKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ98</accession>
    <name>A0A6A6QQ98_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ98"/>
    <dbReference type="OrthoDB" id="3687237at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="732" mass="79111" checksum="08F4DF1CC961DB0C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR93</accession>
    <name>A0A6A6QR93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_77930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6QR93"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF404">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025546895" evidence="7">
        <location>
            <begin position="21"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="686" mass="73752" checksum="29B2D470D83BBCCB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRG3</accession>
    <name>A0A6A6QRG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_511370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRG3"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="238" mass="27306" checksum="60E3340C87B8E2FC" modified="2020-06-17" version="1">MASQDIILYDLPSKGRCHCWSPNAWKTRLALNYKGLAYKTEFTEYPDIAPKLEALGLPPDPVDHDYTIPALKLGDEYFMDSMVIAKELEKRYPTPSLNLDSPKIKRTRGLLGPALESLRPIWMPKVPDSLLRERSVEYFYRTRAERVGMPLEEYAEKKGGEQRWMEALMAIDDLAAFVSATEGPFVDGNDVSYADFIIVGAMFFIKRIDEKDFERLLENAKPVLQQLEACAQWFKQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRH9</accession>
    <name>A0A6A6QRH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_461180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRH9"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="205" mass="23145" checksum="0CD8CA18783F9941" modified="2020-06-17" version="1">MDIDDILAEALHVSAPQETLDLQELTRAWVAERVAPELLPYPDALMERVLGRIRRQIETVEEQTGNMDPKTNFKLIVIQTELERFKFLVRSFLRARVAKNSAEYLSLSESKYLTAHQNLLASHYQSSFLSQFPNSLQKLDDTQGGISMIDAPDPDTAVFCRALRDVGEINVVGTGRAFVMKRGDVRVVRWSAIKEKVLAGDIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRP6</accession>
    <name>A0A6A6QRP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_527816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRP6"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWR6</accession>
    <name>A0A6A6QWR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_336688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWR6"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="91"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="578" mass="65787" checksum="28FBC8FEDDAA45A1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWZ6</accession>
    <name>A0A6A6QWZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_526024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWZ6"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36322" checksum="6764A837060EEC5E" modified="2020-06-17" version="1">MTETTSPTRLPSFSELPLRPSDPPHSAWGLWGESDQLGCLNHLTPARVKAAAAEIKSGVSVGLSWEMHQMHVPPSYRSKLEHEIFSIGENINDDKVAFNTQTSSQWDGFRHWSYPDGRFYNGVTQEEVRNSDSTRNGIHEWTKKGIVGRGVLIDYYSYAIEKGFDYDPWSFTRISVSTVKEIASLKGITFLPGDILFLRTGFLSRYESMPKDALINLMGAPEFHYPGLESSLESLEWLWNSHFAAVAGDNPGFEAWSAGLGDSKERYRMHEVILSGFGLPIGELFDLEELAEQCKKEGRWSFLVTSQPLNVVGGVGSPPNPIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXG0</accession>
    <name>A0A6A6QXG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_538228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXG0"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="4">
        <location>
            <begin position="217"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="339"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2497111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="420" mass="44476" checksum="53021E2B1426732D" modified="2020-06-17" version="1">MDHDTLTAQFCAVTGLGPHDAEGYLESSNWDLETAVATYYAAAEGGDEDADAEDSMDTTDTTEPSAATPAQPGGGRTLDGRPAPASASSSSAPAAARKAPQRGLRTLKDIQNQGAAPAHGDDGDHDSDEDYNDDEQQDFFTGGEKSGLAVQNPNASNPRDQINNILKKARQNVPRPGGDDERPSTHFRGTGMTLGGDDAPSRAIPDPTAERPASAPRVRRELHLWQDGFSVDDGPLYRYDDPANARTLELINSGHAPLEILNVERGQEVDVEVRPHKDEEYVKPKSKYKPFSGSGQRLGSPTPGVAAPSPSSHAPAAAPAPAATASSSSAAAPKVNVDDSTPAVTLQIRLGDGTRLQSRFNTTHTIGDVYGFVDAASPASTQRAYALMTTFPSTELADRKVQIGELPEFKRGGVVVQKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZC7</accession>
    <name>A0A6A6QZC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity mitogen-activated protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_345227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZC7"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="67"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2496973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="457" mass="49449" checksum="EF43938CD47C0F8A" modified="2020-06-17" version="1">MAESSFKTKTMKRKNVKGLALSAPQPKAQPPSAGDSQIPGALGNEDGRSDTLEIGVEFRLDLKAEDLIVLKELGSGNGGTVSKVQHAATKVIMAKKIIHVEAKNEVRKRIVRELRIMHDCNSDYIVAFYGAFQNDTGDVIMCMEYMDVGSLDWVSKTFGPVRVDVLGKIAEAVLGGLSYLYAAHRIMHRDLKPSNILVNSRGSIKLCDFGVSSELEGSIAETFVGTGTYMAPERIQGSRYTVKSDVWSVGLTLMELAIGKFPFGNSDNDDEPGGPQGILDLLQQIVLEPAPKLPKSDAFPSILEDMIAKCLLKEPEQRPTPKELYESDSFLLAAKRTPVDLEAWAVSMMTHQNRKSHLPPALSPATKELLRDRSPPSSATSTARTPTSSDSVPSDTNGAGPAPTRPLYPVRTSSATSQNTMALPLRPAPPPGGSSPQLRSPPGGPLPQAPRRWDREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R025</accession>
    <name>A0A6A6R025_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_616431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R025"/>
    <dbReference type="OrthoDB" id="3795850at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="205" mass="23666" checksum="27B6D45666C1D105" modified="2020-06-17" version="1">MCRPPGQSDSPFQTILGLVWAMPVDIARFGAHLEAYVASSPGIQALRLCCRFGEGVNVYINKLPEELIASVIVELQRPARAIAFAEWSTGFKCFRKDCSMQNHMNGDFLREVQAEYRLEHISPGQLQEPTQTELLEFMAKKRSSSELNFCCLRRILRNARIKNQHGFRKSVNAKVWHRLRKGFFLKFDRARKILLVCFFRMQLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R040</accession>
    <name>A0A6A6R040_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R040"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="121"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="562" mass="63816" checksum="273F0F38D0F2777F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0S4</accession>
    <name>A0A6A6R0S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_559682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0S4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24686" checksum="62E0DB4F3DE2445B" modified="2020-06-17" version="1">MSLHVQLGYIREAPERHADLQKPPPGVSEILPPARAESGETLQTTHALALSFVWGTFTTLTISLGVFIPSKTVTREGREPPVGIRRRLIFTTDANSRPSPRNTKTPQHFPPPPAPQNSNLIRPAIPLHSDHWGKINHRPLSPIGRAASATLFTEHRNRVNWHAGREALPTRLSTQRETAQGPLPASLHSSSPVDVKPMDSLVTCWSLRVTMLWNCDGGPRKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0X4</accession>
    <name>A0A6A6R0X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1776-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_481209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0X4"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="448" mass="49033" checksum="60397DA67CE54F44" modified="2020-06-17" version="1">MTADDQHFLDSIFYGAEKIGNGVADYTNQHIAWVAGSIRKQLEDADWLPQAVRPPPPPPRALSRLPPGYLERVQDWVSQNRAVTAALVAFIGTGSFLLYRKKKTYSRKRRARRASNGARREVVVIAGPPSSPITKSISLDLERRGFIVYVVVNSVEEEQTVQSEARVDIRPLNLDIVDTLSAQEAIERFNNLLLSPHVAFSGASPHNLHFNGLILVPDLIYPSGPIETVSPELWSDALNAKVLSTIATTQAFLPTICEFKARVLVLTPSIVSSLRPPFHGVESAVVGALEGFTTSLRGELGTLGIDVCQFKLGTFDYGSVGGKQHLQSIGGPKTYTWPASARAHYAHNYVTQSRIAGSKGLFNEHGSAASGSALRELHNAIFDALTQKHPRKVWRVGRGSVAYDVVGKWVPAGLVGWMLGIRRVSLDEVAELQLEDSTQSWEKVESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R151</accession>
    <name>A0A6A6R151_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_524396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R151"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="168" mass="18478" checksum="F580D04C54336516" modified="2020-06-17" version="1">MASIPPEPSSEDSNAALSQSLWADKYRGATIEDLDPPPALSVKPSDPISHALMSAFERDYTHLTVVSQENRALLGYLSIPRLKELLKEGKVKENDPVEQAMLKFRRKGKVYKVITMDTPLEELEAFFNGGVNGSGAQDFAVVTDGNRRFVLGVATKSDLATFVQRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R193</accession>
    <name>A0A6A6R193_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_295570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R193"/>
    <dbReference type="OrthoDB" id="3220769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="316" mass="34550" checksum="91F8E0E97E245636" modified="2020-06-17" version="1">MDTATTGRSTINLTASYNLAPKTVSVNTVYTGETRFIGRNQASRASLYWGESLLSLYWWQLTQNMESAQGFTDTKNKSGTLAKGGIYFTPNITLGVNITDPDFFSIGWRFIDQNLGVYWDGGKNKSISRLIHDQSSPSIWYATDRFAKILYSTVLTDLGQTSAHPNILADPALLKIFSNSTWNVTAMSEHLQELGLAIPGFNLPETPIGVPVVNPSTISTTYLCQVPRQKSAGTLIIAVLVADLVFLQALWKLANLIAGKVLARQDPTGNFCEGCLQKTDPLGTDNPRDGSVVPSKNAGMNRDEYELVGVRTTAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1F0</accession>
    <name>A0A6A6R1F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_300360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="360" mass="39480" checksum="1FA0D6B5615642CF" modified="2020-06-17" version="1">MNVGMGHLAISPSSPYDSQNASRVSLVSNLQQQRGITNDPRPNAVSPLSPLGPRPGARPNQAPRRAPVINPNPRSVSGMPDPMAAAPTKGYAWAFPAEIDPEDRRGSSSGDSSGDIHKLSRQNSFATSVNSSVFTVESNLPPGQKRFDDGTRPDYLIDGYGPDGRGDIATTHHHSMQHRNVTSLQSGESPSTPGSGNYSRTPELRVSHKMAERKRRSEMKGLFDELNGILPNSPGSKSSKWEILTKSIEYIKTLAKAHEATRNENARLRPDAEYCRRAQEDCENLRTELHTMWQHMRRVDPNNPHIYGNMTNMLAQQHGQAPASTTILPPLQQAPPWGPPPPSAAMQGVEFAGARPYDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1L5</accession>
    <name>A0A6A6R1L5_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_606602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2497830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
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    </dbReference>
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        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="31972" checksum="7F509EEE2D5C7301" modified="2020-06-17" version="1">MAFPWPTFTKNFHSSIYMAIDPSNPALSVKGKTILVTGGGRGVGKYIAKVFATAGASTIVILGRTASSLQAAEKELSAAAVAAEHDTIVRSFAVDICDTEAVSRTVETVCREFGAIDVFVHNAGDLKLGTIESSNTEEYWRSFEVNVKGTLNCMQAFTRFGMISESTTAPTFINVSTMGIHMAPVPTMSAYSASKLAAWKMAEYLHVEMGAKLRVFSIHPGRIETDMSRRAGIPAADDNELPGAFCLWLAATPGVDFLRGRMLTCNWDVSELLERKDEIVEKDLLVMTLAGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1X4</accession>
    <name>A0A6A6R1X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_579646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="117" mass="13121" checksum="FFDD42DF75114CB3" modified="2020-06-17" version="1">MASTTPTLTMLLTVTIDPSNTAAFLSALKPIYNSISSTPECTFVQLLQSPAQPGVFKIVETWNATMEWLQTVQLKKPYYAELAEKVQPLYTKPQEIEVWEGMPGGEWVGVSKEFYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2R7</accession>
    <name>A0A6A6R2R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_579675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498574.1"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2499442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="647" mass="67265" checksum="2474B213C9213A2F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R569</accession>
    <name>A0A6A6R569_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BU16DRAFT_482064</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="37"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:71302"/>
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        <recommendedName>
            <fullName evidence="4">N-acetyltransferase B complex non catalytic subunit</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lutzoni F."/>
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                <person name="Ramirez L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
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        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
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        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
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        <property type="entry name" value="3HCDH"/>
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        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="225"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34388" checksum="56EF99D05DCBC5AF" modified="2020-06-17" version="1">MSFSVASRQILRTSARTQCRSFSSTPSVNAAAEVKKLGVIGAGQMGLGIALVAAQRANVPVRIIDTSQASLDKGLKFADKLLEKDVAKQRISKDDAAAARERLISGTTLDDLSDVDFVIEAVPEIPDLKAKIFAQLAQICPSHAILATNTSSISITRIAASTTKDPTDLSASSRVISTHFMNPVPIQKGVEIITGLQTSQDTLETAIEFCKKMGKIPSTSADSPGFLANRILMPYINEAIICLETGVGKKEDIDSIMKNGTNVPMGPLQLADFIGIDTCLAIMKVLYDDTGDSKYRPAVLLKKMVDAGWLGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6F9</accession>
    <name>A0A6A6R6F9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_523151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6F9"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="293" mass="30348" checksum="5C1F7FF398B407F6" modified="2020-06-17" version="1">MSSSSRIDQIAGHLNYPKGLLAGQVAIITGSGQGIGAETARLFAKEGAKVVISDIDGKKASDVADSIKAAGGSATSVAGDMLDDNYINELVKKTAEFGNGKIHIIVNNAGYTWDGVIHKTTDKQWDTIIALHNTAPFKLVRAAAPYFRVKDGEPRCIINISSTSGLHGNAGQANYALAKAGVTGLTKTIAKEWGPQYGVRANTVAFGHILTRLTAAKEAGAFITTPDGQKVALGIPTGKGALASAATKEQYTDIPLRRPGTATEAAGAVLAVVSPLFAYVNGQTISVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6L5</accession>
    <name>A0A6A6R6L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-dependent alpha-hydroxy acid dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_268779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6L5"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="368"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="446" mass="48614" checksum="AE6DB7D4DB9AD58D" modified="2020-06-17" version="1">MSPSKPSSANQPYTTPSAIAPTQYQRTIYSALRAPSISTKPSEWEARARAILPAPNFKYVYGAASSGDTHRENTDAFKRYRLRPSMLVNATRRDLSVELFGITYPGPLIVGPVGVQEIMHPYAEEATARACKALKIPMVLSSAATRSIEQVAAANGNGDRWFQLYWPKPQAEEITVSLLNRAKAESYKVLVVTLDTFTLAWRPEDLDASYLPFIYGQGCQVGLSDPVFNARYEEQLARERTEKGFTTRLGEALETIRRPGSISGAAKVVANAATMKKAQAWMSILNSGTYREWKHLEILKKYWDGPIVLKGIQTVGDAQKAVEYGMDGIVVSNHGGRQLDGAIASLDALAEIAADETVKRSGITVLFDSGIRTGSDVLKAIALGAKAVMVGRPFMYGLAIDGEEGVKHVLRCIAADTDNMLGNMGKRSLGELSRNDLRVLGQPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6V0</accession>
    <name>A0A6A6R6V0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_453902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6V0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2499600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="364" mass="40138" checksum="6F2DEE5E6BF59CE2" modified="2020-06-17" version="1">MVHASGRDREVYDHRQHQQHFYAHQSRHHVPVDVPQPPVHHYPQPQQHPQQEYHYRAPQSPPSPPVEEANKPSLPSISSLLGIADGDRANSETAGMSPHQSQQQQPSPSTQHPPQNPISVQQPESRPEQTAQAFGPAIVSNPRMTLPPTPPMQPESVVDGNQSPSAASTHSSVAPQPYYLGQSLNNMEPHQQRQHIPNPPMVKRHSLPSQQSMSPYNASPYVTSPYGSSPGAASNGSFYSPETHPYPAAGMYQQRPLPSNFAPQQMPIPVASNPANPSNLWQHHHYISQSSQSAFPQSPDRYICPTCNKAFSRPSSLRIHSHSHTGEKPYKCPQPGCGKAFSVRSNMKRHERGCHAAANVMSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6Y7</accession>
    <name>A0A6A6R6Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_534852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6Y7"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R941"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="96" mass="10744" checksum="B0144D7EA84C4F58" modified="2020-06-17" version="1">MSGMHERDWRKCVWRNAVVELWLVVARLTLSEGYRVTIASETPLGWWTRFLMSENLVVSSGGSIEVAVGKGIGVGVSERAPQFYESVEWKSKTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9C3</accession>
    <name>A0A6A6R9C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9C3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="565" mass="61359" checksum="DB3B95773C287BD0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9Q4</accession>
    <name>A0A6A6R9Q4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_599526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9Q4"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="467" mass="51702" checksum="F1DE684E734E100C" modified="2020-06-17" version="1">MAAFMRLLWASSARNPTPPAKSDNDDIYPVHMLDDTKTLRNIVVTSTLRFNDVLDAEKLHDSLSQLLEIGDWRKVGGRLRLKDEGKLEIHVPRPFTAERPAVTYSHQAINLNIEEHPLAKTLPNATETPSIQPGPQAFRIFAARKDAPETLEDFICQDRDTPQLSLHVTSFDNATLVGLLWPHTLMDVMGQQALLRGWSLVLAGRDSEVPPLLGAREDAICEAVDLPVKEKDQEEFRLGQKRLRVAELQRQARGELPATDGEKPFIGEGDVLTAWAVRAVASSLPQPRPITVVHALNARFRLSSLIQASGVYVQNMAVAAFTFLSPDVATSLGPIALENRRHLMEQSTEAQVLAFLRELRSTPGSDPALVLCSESDAVLMPFTNWTKADFYKTADFSPALLRAGEAGPLRSNPPGTMVFHHAQSMRQGSTVRNVVVVLGKDHGDNYWLTGILLPQAWAKIEEDISRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAC4</accession>
    <name>A0A6A6RAC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_555873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAC4"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2501384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="191" mass="21451" checksum="B184F8BE41E002FA" modified="2020-06-17" version="1">MADDTRQSSPAYPTPKAEDVAKEAARYRTPANTLPGGTANTAGGEKLDDQSLLTKAVKMITWDDWKNIGRMPCAKDSLMTGILSGFVMGGMMGLVGRSVWTACNISVGAFMLSSTGGYTYCQYRRGIERDGLRQVQAVASAKKAEHEEKRRKAIAKRREEERIMKEKLEEERRKSWSYWASRNLKFWGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB59</accession>
    <name>A0A6A6RB59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB59"/>
    <dbReference type="OrthoDB" id="10604020at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71815" checksum="76414C4133445DA6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBJ7</accession>
    <name>A0A6A6RBJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_190669</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBJ7"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025394313" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="216"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2501113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="609" mass="66336" checksum="5A86456FAE713BAB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBJ8</accession>
    <name>A0A6A6RBJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_613750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBJ8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="546" mass="59197" checksum="69B895B8818C0816" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC38</accession>
    <name>A0A6A6RC38_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_554420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5361176at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1452" mass="166807" checksum="29753EC0C795935C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCG8</accession>
    <name>A0A6A6RCG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_521009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="40005" checksum="2954208936B7598F" modified="2020-06-17" version="1">MAARNRPRAGQVKDEVDEERSIWSQIRSDAKRGDQLLKTSNELTKQIVELYEKQSTLTARGESPSAGVDTELEERLRANIKLTEELQELIESENGNDILKSLEILAALRDAHEPDPSSRAGSAGKSQRDRNTKRKHTETLEDRESIESPGVSSPKVMIPISASRLVKSAASRANSVPVAREGSVKADDGGESADSLKLASEKHKLHVHTEVLYRNKAKAAEGEGILCRVTSVIGEGKQRRYEIIDSDPDPPTPSLPYRASVNHLVAIPPPSANTTLPDLPAKRHVLALYPGTTTFYKAEVVATWTLKNRKEEKKGDGDVKEEEATGTVPAPGPEYFVRLRFEGEDEADRECSVERRYVLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDN1</accession>
    <name>A0A6A6RDN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_577673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
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    <comment type="cofactor">
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            <name>heme</name>
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        </cofactor>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="527" mass="59866" checksum="2346945F2D26BDAE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDZ3</accession>
    <name>A0A6A6RDZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_522588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDZ3"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="370"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2501677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="576" mass="62960" checksum="C2906F16C84D19C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REB0</accession>
    <name>A0A6A6REB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_521716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REB0"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="903"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="195"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
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                <person name="Bloem J."/>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFI0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2503112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="485" mass="51939" checksum="6ED2DA5A4D68F8D8" modified="2020-06-17" version="1">MPGPKRYIETRLLINGELVESKKTFDLINPATLEPVAKVYEASEADTNAAVAAAKASFPAWSALSVEERAAPLKRLAQLIRENQNELASLEAMSMGRPVTHFIDAKEAASRIEHYAEAGYEVQGTTSIQTPGYVNMTFRQPYGVVAAIIPWNYPLLFLAGKLAPALITGNTVVLKSSEKAPLTSAKVATLVLQAGFPPGVFNIITGFGNISGSVLSHHMDVRALTFTGSGRTGRLIQAAASKSNLKHVLLELGGKSPAIVFADADLSDAVAATVQSMKQNSGQVCMANSRIYVQASIAAEFMAAYQKTFALVTMGDTLDPATNHGPQADAAQHETVLRYIEDGKKVGQLVMGGEAAAEQNGFFIRPTIFTGAPENSSIMREEIFGPVVNINTFETEEEVLAKANDTEFGLYASVFTKDIDRAMRFAKELESGVVGINCTSPTHMKDGPFGGYKSSGSGREGYRYSMENFLETKAVCIKLGGSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFV9</accession>
    <name>A0A6A6RFV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_427857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFV9"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2503222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="253" mass="28607" checksum="5BFF74CA4DE2877B" modified="2020-06-17" version="1" fragment="single">PCRLCHSDYCKSCVKGMFIKACKDTTRMPPKCCSILQLHVALPMLSPDEAKLYREKYEEWSTPKPMYCPIPTCSAFISNRSLPVVPPDTIKKGKARVDSVIGTPKEVQVSCPKCNHDACARCRQSAHPGTPCQLLDFGVDKETAAALKRWGYKQCPKCGNGVRRMMGCNHMQCLCGAQFCWWCLVPMDECGGNCYEPEEEENDDYDADEIEELEPINLDIASNEYWDARHANFGSEPAEEPPDRAWQCEHRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG84</accession>
    <name>A0A6A6RG84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_476215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RG84"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
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            <end position="624"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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        <source>
            <dbReference type="EMBL" id="KAF2503372.1"/>
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        <source>
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    <sequence length="683" mass="76242" checksum="65CE76489517A5D6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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    <sequence length="1392" mass="155545" checksum="F2D4AFD6516846AA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="EMBL" id="KAF2489474.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QBR9_9PEZI</name>
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            <fullName evidence="3">RING-type domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </source>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025430610" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="133" mass="14425" checksum="97B5AB1508D0954F" modified="2020-06-17" version="1">MKLTSVSILAAIFASTLAAEPLCVSQGSGYCQAVYRCHKKTSDTIFLDCIFGIYDSSCRFIGHTDAETDGQGLGAAGIPYKVIVKSHLPSSDPNKIKMQMEYAGVGSGKTPGLVQQSYVLEAGEMDWDWRQKH</sequence>
</entry>
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    <accession>A0A6A6QBX3</accession>
    <name>A0A6A6QBX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBX3"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2489772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="26320" checksum="2B375E302F179ADA" modified="2020-06-17" version="1">MTGKVILVTGSNQGIGFAIVQALSQRAPEHTYILAVRSLDFGHQAIRKLRELGITSRLEGILMDVTDDAQIAGAAARVGEKFGKLDLLVNNAATAGVPKPDNSDIRQVYDNVLSVNVTSVAAVTYAFLPLLKKSEDPRVINISSARGSITRLTAKVMPKTISIPYCVSKAALNMLTMEIAEAEPEMLFYVVSPGHCKTAFNGFRGPRDPVEGAEVAVELALSERGMYKSALWENEGNGMTEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC41</accession>
    <name>A0A6A6QC41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_531112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC41"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20406" checksum="DCDAC770B4BEE541" modified="2020-06-17" version="1">MLRLFRYEGGEMKVVAEPHSDLGLLSLVIGDTPGLEVWDIPTQCFFPIEKTYENPAGSLLVGRQLERLSNYRYRAGGHQVKAYGRTEARPSTSPSRQPQPNYRYSIVFVLRAHEPVIVDTDTLTTQITGKFEKPIRGVTAGRFYEQIRNAHFNININVEEREEQRKKVAAKKAAEGVNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC42</accession>
    <name>A0A6A6QC42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_168609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC42"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="67" mass="7399" checksum="9172DE05885C1967" modified="2020-06-17" version="1">MRYSTLEVSNAELALTLLYINYVCIPSYFLTESPLGGWLSGSLQCLLGGGDARFRVVGFLVDKIPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDE0</accession>
    <name>A0A6A6QDE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_471105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDE0"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="136"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="54100" checksum="D4DD3E0698D8C6E1" modified="2020-06-17" version="1">MALVPSPKSEFHVPPPDTFEEPPAVVVPDAGDPWPRPYYLENGLRKVRPYHFTYNTYCKARWRDREILDIFASEFRDRPLEYYKSAIESGYITINGKPIPSPSSLIRNGDVITHTIHRHETPVSATPIGIVYEDNDLIVINKPAGVPVHPAGRYNFNSITEILRAERHYTFNPLPCHRLDRLTSGIMFIGKNKEAAERMSEQIRSRTVRKEYITRVVGEFPEGEVVCDQPILQISPKLGLNRVRANGKEARTVFKRLAYYPPKGGDNGVAGDIAENQKTKGMEWKNLRGYSILRCMPLTGRTHQLRVHLQFLGHPIANDPIYCNQRVFGPSLGRGEEVSDNDDDIITRLGRMGKDEVAEAVAYHDEMVDNYEKRRAEKMSGEVCEFCQTALYTDPGVHEMGIYLHAKRYACTDGKWDYETPLPDWALPPPGVDGPTEATKESDPLAVDLKKLGLEDDESSIQASSETPEAHSSPAAVSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDK2</accession>
    <name>A0A6A6QDK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_531430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDK2"/>
    <dbReference type="OrthoDB" id="10583732at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27074" checksum="146D814C8AF4D985" modified="2020-06-17" version="1">MASPYSESLPAPETTSEEAPLLGSSDPSSEPPPTPRPQLGKPILGLTWLSLALAATTWPFLIALKVLWDHEPIDYHYSWGIRDDASALLGLSIAAAIFATGNLLRLRFSRLYLPLLLNLIADLVLAFYLIAVSANGIADGLQGDCYKSWYPPPKIGDPGHEQPLPVEPGCYRYAYRVTVLQEVVMSLGLVLGVTSLVLAVLRLVLAYRSKFWRRMSIPTGTFSVEFSVKILRQGDPNAPGQGQAQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDY2</accession>
    <name>A0A6A6QDY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_146113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDY2"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="13614" checksum="CE396F257BC2D243" modified="2020-06-17" version="1">MAAPHYPPLYGAPKGVRFVIFISVLEPLAIAVVCLRLWARHIKRKRFSFNDYAVLGALFVTIILSAINFVCGSFLLLPTVSVSASRFRSQCPRRSMGWNWPPHHRCRPTVPRPDLESLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGB6</accession>
    <name>A0A6A6QGB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGB6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF33">
        <property type="entry name" value="OXIDOREDUCTASE BLI-4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="340" mass="36934" checksum="73F6FC5AC333A0B9" modified="2020-06-17" version="1">MQTIKNTLAENLTGAHSLAPDSGKFSLEEVPDLSGKVALVTGGSEGIGYGCTHTLLSKNVSKLFILSLSEDIVDDAISAIRSEMGDAAAEKVRWFQCDLSDWSKTGDVAFQIAKETDRLDILINNAARGIMTAQLAKNGIDQHMAQNHIGHVVLTSHLLPLLKKTAEQGNTVRIVNLASNAHESAPKETKFESVEELNKDYGAMAQYGRSKLCSILYATYLTRHLNSAHPGILANATHPGIVETRQSSDHIFEPYPLGGYAMKYGMAPFKKSQFEGCVSTMFAATTTKKSGQYICPPAIVEPGSELARNEALSEQLMKLTWQVVKEKTQAASEGCPLKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGH0</accession>
    <name>A0A6A6QGH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_566047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGH0"/>
    <dbReference type="OrthoDB" id="5391053at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="453" mass="51549" checksum="21CCEF8DC4BE3DCF" modified="2020-06-17" version="1">MAVTDFVKQTLQFVAGRYHALTRMADESTTSLAIRAEEDAIPEETAPLTVEEAMFPPAVGCFFGEEEENDYTSGPAKMVVVNDGANASAALLLSYDLSKKIQDAVMGDRVLQELGLQIDQQRSNINAREQDLRYTILRIDRKIERLELKFKKASKLTDEQVRETEEHRAAISDLEKQRADLELEDHDLRERWEAAQQRQQMLQREVNVIMEDVFVKCQLLPPQESFDGSQMEPFDGEGSDQFPDAPEGLEFENHLGEIPQAQNVTDDYQDVAMQASTNLEHRKGDLIRAQRSFDTYQTGYDASLQQYLSTQINRPIIDSQTEHDLLHLQRGRTLTRRLIDAEEALEAAEIAAKAARCPTNYFQESHFGDGTDDGYRESQEAAIAAQVDRKKIEAWLAKEPANGDMRRPSEAKTEPEVDEWSVDEEKPFDSVSVLAEGSRRKKIDKWRRRTGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGT1</accession>
    <name>A0A6A6QGT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_469150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGT1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="302" mass="34017" checksum="62C2C85D7B2DA19D" modified="2020-06-17" version="1">MPVADVFSLEDRNSFTTSLSPSVTNYPLENGRRYHAFRPGVYVLPNDEAELDRLDMTHFLLKKAIGDKLHLAPIPDTVKRVLDCGTGTGIWAIEMGEAHPAAEVLGNDLSPTQPTWVPPNVKFEVDDLESTWTYTAPFDFIFARYLCCAIQDWPKLIKSAFDNVAPGGFVEFQDWNLKYHSEDGSLTEKHEVARWDQILIDLSAQNGREPNPGPLLEGWMKDAGFINVVAKRHKLPIGPWAKDPKQKEIGLFNLCQIIDGLEGFSFRLMTQILKWSPEEVEVLCGKVRTELKSKGLHALLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHD4</accession>
    <name>A0A6A6QHD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_621145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHD4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="42"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="42589" checksum="D9450A9A92CB43A7" modified="2020-06-17" version="1">MSLKRDMPDEPFETPSRPRKRNRPFSRPKDARIANLFKRNARESRLLRLPKELREKIAKYLYEPRILHIKRRAEHSAKLGSHGEASPYERISQTSKSLETLETAYSIYSSAEEIAYFNFEHDRVPKSPHCNSLLELEKVDLRLFRTCRQFYFDFADPFWNQTMFSFQSHQTFVQFLLHRTASQLCSIRKLRLALRGQNFDRRVPTAKMQLLTGLHSLYILTAGRHNLEKKGILQFRFLPLKCVKVRCRGYSQEVSHAIRDKLLSTHDKLSEQIEDRRQKREKNEASNRQKIERLKLREEENRAYLRKVAATGTRHTRSHCGWGTKAECDKHRLGLLKERGLPGERDGTTCGARHWCEVCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHN4</accession>
    <name>A0A6A6QHN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_123206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHN4"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF14">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="269"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="624" mass="70506" checksum="FBD29C6AA0B4D0E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHU3</accession>
    <name>A0A6A6QHU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_125351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHU3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="114" mass="12797" checksum="7E3CF9D75B2245D7" modified="2020-06-17" version="1">MRGWFGGAGGLDVGWIYVTCVYLFVALLEVLVLRAALLEDADGGLGFEEREDLVIAHCIVVRELRFPAVEQQFWTESALTRPRRALHWARMGLISFEVCLVSNVIPPQCAHRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI14</accession>
    <name>A0A6A6QI14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI14"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="52"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="317" mass="36995" checksum="7CFAA854DA1956A3" modified="2020-06-17" version="1">MFKFIKEKRQERGRSPRERMAASFTRPPRERSLSIPLPPPTLLARRKQKTNTQMQSALFSKLPAEIRKIIWEYAIADDDKQIHILQYKKRLRNMPCSYHRGEQPSVYTGFHKCAGYEGNYGNALEVQPGAQLSPLVKTCRQIYTEAIDILYSHTSFRIEHLDTLTYFSTFVLPHHFNRITTLRLLWFFHIDIFEDLPNPTKPPHDLATWQQTCDILAGMEGLVDLDIELSTETSYFKKVSSRVRLLQSMKDIKPKGRFDVTAWAPWPWLWFTQKEEEDDMEGVQALFSILYPDLGGLQLEGMPFRIVDAKFYFPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIQ3</accession>
    <name>A0A6A6QIQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_565581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIQ3"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38006" checksum="A36BBD67F9B04647" modified="2020-06-17" version="1">MAADWDNSQTGTSWKPYMAYTSRTNPEPSLPEPGIAGYATQALLEIRPGEEMVTIIVGTGQYDVAGGRIAQATFQTSKDYICKASSFFANAFRGSFREASQRILRLPDDEPSSFRLWHDFYDKNDRKKSWESCLNPPHKPRSFFWELHPNAKTRATLWELVKAWLFGEKYSLPEFQNFLMSILRRVTRSGSPSNGTPGYCIPLSIMKYVYENTLAGSPLRFFLVENMCRQLHDRVKRWEDFSEMENYTGFAKEMFVGRDNCNFEGKDQCVWKMRDHLFHVGANIERQANVNGMMIVSGAKDHPELCEENVWYSFTKNGGVDVVRDPNDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIU3</accession>
    <name>A0A6A6QIU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_467053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIU3"/>
    <dbReference type="OrthoDB" id="5413793at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2491926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="397" mass="44205" checksum="FCC9A32940D0E223" modified="2020-06-17" version="1">MQDRTLLTRNLNYALIAISTVILLVRLNVRLFMIKSPGLDDVFAVAAWATLVTLSSLEIFETFHGSGKQMVLVGQQDLAIFFSILPTMQLLYIASSGLVRLSIVAFLPRLNKEAFFKKIVHALGGLIAAVTTVCFLILLFECQHVPDLWNKRRLGAQCLAPSREAILMYTHTSFGILFDCLLLALPIWVLYSKMMFNSQSLRVMLVFTVGIFAAITGIVRLAVIVRINMTINTTFNISIASFWTDLEGHVGLWVACFPALQPLLRLVSFKLGLRSRLRFSSKRGNSDQARKNINRSAYEKGPNLGTRSTQSPHGRANSIWSEIRITAMPDIQPVEMDHLPARASLRSPDGSVGSDRRPPSRGIVVTTDVLHEIEPWGTADPEAEGKAQDRKEAWLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK29</accession>
    <name>A0A6A6QK29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_515433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492459.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="19537" checksum="F8B30C762ABCCFDE" modified="2020-06-17" version="1">MGNANSAILDNIASGSNFDRDEVDRLRKRFMKLDKDNSGTIERDEFLALPQVSSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSAKGNKEEKLRFAFKVYDIDRDGFISNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDGDGKISFEEFMKMVENTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKU4</accession>
    <name>A0A6A6QKU4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="13">Dynein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_541525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60406" checksum="E66DF2058DA99839" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL04</accession>
    <name>A0A6A6QL04_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
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    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
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        </location>
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        <location>
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            <end position="43"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="166"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32434" checksum="7D0BCA39811691B8" modified="2020-06-17" version="1">MSADKSGVEKVLEGSLFGYGHWFEPIDKAFGTTLEQQPGSETPSGPVEKPKGRGRPRKAQNNDDAGKDKRRAQIRSAQKKYRERKERATASQEQRCDELLRVISDISMELEELLKVACATGAMDTDDDLGEKLRRTASCYDSAIERPCIDPELRLLRTKSRQRRGNSRPDTLSPPTDDEATPQPQHAPLNRDDSAPSTSTPNTLREWRETTHLIELDLGRVSDSSLIQSFVPHPGRKKALGAKMMLDLIKQRQADLKAGRRSKPVTAQDVDFTQRDSDGVLAEPLKFGSQG</sequence>
</entry>
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    <accession>A0A6A6QL38</accession>
    <name>A0A6A6QL38_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
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            <end position="203"/>
        </location>
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            <end position="262"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="50435" checksum="CE314BC3C81812EE" modified="2020-06-17" version="1">MAPDQGQLSLWREYNALVARNEGAERKLKEANRAAEALVRAQLTEAFGETPEPEVATAIVSTPPFTPRDVPKVQAPPAGLEAPSTPRHVTSTAGPPPATPPVTPYHISRVGHGFSNALSERASTVAPDETDVLDMDVDADLQNRERVEVAPQNLANPGVNLSTSPADVVKPEELSPITVQGGEVVDLCGAYTSDEAEDEEMVVVEEPKTPTKPPPSLARHFGSFKGDPVSPTSPTSTAEKTGRSQAQNEQNVAPPTQSQTHTARPVQKAARGATSIITSPKPAATASAAGSLSTTNPSTPKPALKRPASMLIVLSDDDSDYAPQDSPPPPPKRQRPASSAKKSVTIASPPVTPTSSSRKSGPTNAKSVLSKKPGPSVVKPAVSHARMASHPQLHHPLSPATNMRMRLALMAPPPSLGVRAPRAAATKAREMTGMVVREEARLREMSDDALMVEIENGRLARLSLEPPERRQRPGAKP</sequence>
</entry>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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            <begin position="1"/>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="182" mass="19945" checksum="D8082921935B6757" modified="2020-06-17" version="1">MPVLPSTVSKPPPPIQTLATSSSESRLPMAQTPPAEPSPASFMSRRSTQGSTSSTTSPVEATFFETIASKVKRGRSRSRSRQGVPRNRSKSPLPPDHLSSSSARTSTSPPRPQQTRHFSTISQDSTRSSNDGSKRFDPTPTRRATASSDPWRGRHANSWLFNDFSVTDHAKDLFHRGKISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492929.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QM03_9PEZI</name>
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            <fullName evidence="6">Choline-sulfatase</fullName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Choline_sulf_C_dom"/>
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    <dbReference type="InterPro" id="IPR051849">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615:SF1">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="5">
        <location>
            <begin position="562"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="638" mass="71005" checksum="D38F44B7FC5866B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM28</accession>
    <name>A0A6A6QM28_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_529268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM28"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR010730">
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    </dbReference>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="102"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="43047" checksum="B0EB84B73CB176A9" modified="2020-06-17" version="1">MFSYLEHIVKAWQFTFPCFGLGHLLPISTVHTISFGFWLRVTSEETNSHATSAAMRDAPVHFTPLERERSDFRLFHLHPGFDGDVISGSLKCHTLGPARKSFEALSYVWGGTGDCATILVDDTPVSVTKSLEAALRHLRFPDSHRTNWVDYICINQGDIEERNQQVAMMGLIYEQATSVLVWLGEATPNTVVGMKVLGYFANEPRPQPHPIWEHYPSSVVQAGLLDIMNRSWFQRIWVVQEVGRSGTAVLICGQHKVKWQSNDSVAVGRFIRMIKYAEILPQWEQMGLGTVNMQPLLDMLDLQIGNQLDRSWGGTHRTAPDILDVAHSMRHKLCTDRRDKVFGLFGLFEHMWVYDGFKPDYNMTTTQMYEALQKIAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMB7</accession>
    <name>A0A6A6QMB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_79352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMB7"/>
    <dbReference type="OrthoDB" id="3733501at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="298" mass="34367" checksum="F4240B101FBD1468" modified="2020-06-17" version="1">MSNIPVINTEDDTSQGAETKSSTYASHIMTSDDCLSGLGCTEIDFMKFPGEIRNKVYDLITYERMHMDHQYLLKPKGPLPVPMTDGLLELRLVGRQFSDEVFNRMFAWGATLRLNMIPVLPKGLDVRMETESTRKNMRATCPTGTANIAAEFGFRLRSYRPLGPVPSVWAKVLKNCQIHLLFRRCRNSDRCTACMNLNFHKEKLHFDIMPTLKDLIEYHVECFPDLPLLDVHMVQEQNWLSFEGKKMVERGVEEDFVATSEGSDGNALEWYLRTRYQGIKMKVQIRTMDNELPSWIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMH3</accession>
    <name>A0A6A6QMH3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_529483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2492117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMH3"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025505153" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2492117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="210" mass="23723" checksum="2E23C442F7550C53" modified="2020-06-17" version="1">MRTILLLSSLLALFTSAVYGTALTYKLGANEKSCFFSYVEQKGAKVAFYFAVQSGGSFDVDYSVVGPSEKVILDGTKERQGDFVFTANDVGEYRFCFNNEMSTYSEKMVDFEIAVENEARAQLPSKQGTSPEQTSVLEESILKLSAQLSTINRNQKYFRTRENRNFSTVRSTERRIFNFSIIEGVMMVTMAGLQVFVVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN44</accession>
    <name>A0A6A6QN44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_489997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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            <end position="539"/>
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    </feature>
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            <end position="80"/>
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    </feature>
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        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="579" mass="62032" checksum="A36B6238BDC9C4EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNX7</accession>
    <name>A0A6A6QNX7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">BU16DRAFT_527918</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="242" mass="27297" checksum="2A612C1EFC7CB437" modified="2020-06-17" version="1">MAPPQGVTLQLADYLNNGEYSDLQVRCGSITYKVHRLVLCSQIEFFRKACSAYWREGQECVVNLNHDNAYAVDALLRYAYSGKCDIFAESVASSRKALHYVQTYAIGAKYEVTGLQNLAKDYLRPLIEAHGGEEWLADVIRLVYETTISTDRGLRDIVVDFVVENHNIFAEQSDDDPIPTVMEELGAFSRDCFVRMSRGKKVANHALKTVEWKCGGCRMDWPVQTREYSTCNGCGFCGYPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPA9</accession>
    <name>A0A6A6QPA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_564064</name>
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    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="494" mass="54338" checksum="6E00D5BC984F966A" modified="2020-06-17" version="1">MSEVKVKQSVNAYTWGCGLFAAVGSLLYGIDSGIVSTTISQSAFQEYFHPFTPSIKGAVVSTFGGGTVFGVFFAGWAADYLGRKKTIAIGAVIALIAGIIQASSVHIGMLIAGRIVGGFAVGIMNMTIPIYNSEIAPPHKRGMIAGLHAQFVGIGFAVANWVGFGCSYASGDFMWRFPLAFQCLPAIIVLVGIFWLPYSPRWLLEQERDEEALAVIKRLHGNIGADDSFFRAEFYQMRDQLRFEKSQQSATWGELFTKKTNRKRLILAILVQAFTQLSGINVINYYQTDLYKGLGMHGHTVTLLAGVYGLVGPIANLICLRYVDTWGRRKTLWITGIAMTIDMSLVMGLSGGYGKSDNMVAKGFTIAFIFCFSIIYSLGYNSIHYIYVPEIMSMAIRAKGSSIAIICNVLINIIFNQVSPIAFADVGYKYYSLFICTNIVGAITVFLIFPETKGKSLEEIGQIFGEEVVVPDLQRVQEKLGDEEVVEHLETKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR36</accession>
    <name>A0A6A6QR36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_463765</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR36"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000050">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="43"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2494193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="742" mass="82624" checksum="8BD78607321AA2C6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR95</accession>
    <name>A0A6A6QR95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_527693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR95"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35450" checksum="776B7FFB1EDD5A63" modified="2020-06-17" version="1">MARTLDVVQQDVMHQEKSAAELRVMMKQLRDSVKEDPNNIDPGLQDLIDTTQAHLNEDEAKLADLIKELAVLQAKSQEAAEPEKWSREKHPVLGKKAQTPDTTTGEAQITNQFKVNDMVLARWIHGDRGFYKAKITMVMGSVSAPKFRVKFPDFNNDTDEGLELGDLKALDPSKKRKAEETTAPAAAPVKPSIATTVISAPASINMNLVTQARQEPSMVSDGPTKPPKIRRKATGTKALESHKSNWQAFQAKGSKKVKKESMFRTPDLPNARGKRPYLTQNLLLILDLVGVTGSGRPMAKDPTRVRHTYTIENEDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRV4</accession>
    <name>A0A6A6QRV4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_50048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2494862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="16384" checksum="4C5FA03C10942033" modified="2020-06-17" version="1">MKESIIMPTSANSTAISTRPSIPFLVQVQHYIATHALLLLAVAYILGRYNAVTHLFRAAYRTLKFVLISIDRRPLLLGLTPVVIIWLYFNLQDRDCVPLWRSDRAWLTEVRHALWIMRECFYGGWACERKRYREECGWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS03</accession>
    <name>A0A6A6QS03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_582706</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="194"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="460"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="784"/>
            <end position="858"/>
        </location>
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    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1077"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1171"/>
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    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
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            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
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            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="80"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2494914.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="1205" mass="132901" checksum="1AC276A8552A9F3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSF3</accession>
    <name>A0A6A6QSF3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSF3"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39985" checksum="349D0838767EAC2F" modified="2020-06-17" version="1">MVITNPPPRPPFSSLPLDPSGPAGNAWGLYGSEDALGALNMLTPAVVAAAATEIKTGERVSLDWYLNKPSHPSFDRNPFEWKLVNRSKPDGEKRAVNDDILTFNTQCSSQWDGFRHYGKFFFIGRDIEESEKSLTPLLLTAGYQKAKRFYNGHVQEELDDPNVIGIDAWVSAGGLTTRGILLDYPRFCTTHSLPVSALTSTSIPLSHIRQMLASTNTVPRAGDILLLRSGFTLAYEALPPAAQAALATRPSPDFIGLEPSLAVLRWIWDSGFCAVASDAPSFERAPIAGPHTAIGGVWAGESFEGEMQGGGLLHQWLLAGWGVPIGELFDLEELARVCEEKKRWSFFVASVPLKVPGGVASPPNAVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSV0</accession>
    <name>A0A6A6QSV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_561494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSV0"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="33300" checksum="052BCEC584CD96A8" modified="2020-06-17" version="1">MKSSPNLPIRVLTHNIRYATTAPFPGEALWPIRLPRLLAELRYTTLYNPEAFICLQEVLHPQLHDILNHLNADVNPTPNPASSSSSPQIPSSPPQSQEWAHIGVARDDGHHAGEYAPILYRPAVWALQDFRTVWLSPTPGVPSKGWDAASVRLLTIGVFKHRASKRRVVAMNTHLDDQGAVSRFESAKMIVAEIVAEQEKGEGEVPVFLAGDLNSEPSQEAYEVLNAGGSPVRDAKGEVGGRGYGHEMTFTGFEPKGERAKRIDFLFVGRGVAVRGLAVLESRFEDGVFVSDHRAVVGDFVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT46</accession>
    <name>A0A6A6QT46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_462198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT46"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7239" checksum="D2447D380D6CEB8D" modified="2020-06-17" version="1">MEGAGHQMNAAGYSEAEQKIDHSTEDISHAAQGHKANISNPNTSEKSKQHSKEELEILGGNKAFYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUC9</accession>
    <name>A0A6A6QUC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_461223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUC9"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="490" mass="52751" checksum="997A69CE15B5B451" modified="2020-06-17" version="1">MSIDANTQDFQRERSRSARRRSRSPRRSRRSYSPRSNSREREDYRRTDRRSRSPGAAAQGGAASFTGSYGASRGAPPTRNPEERVQAKEQMMQSLRESSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLLLPNGMSKVRIVEYATREQAQQAVNTLSNQNLMGRLVYVREDREAEPRFTAPPARGGFDGGMGRGGFGGGPNFGPTQGGAGGRQIYVANLPYNVGWQDLKDLFRQAAHTGSVIRADVHMAQDGRPKGSGIVAFETAEDARTAIQQFNGYDWQGRQLEVREDRFAQNAPGGGYGGGRGAFGGNFAARGAYGGARGGYGGARGAFGGNFGGGRGNFGGGGFGAPAVAAGGFDAGGASNPPNDFTDFATSGGEESEVIYVRNLPWSTSNEDLVELFSTIGKVSRAEIQYEANGRSRGTGVVQFEKLEDAVTAISKFTGYQYGGRPLGLSHVRYTNVSNGGEAMEGTEATGGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUH4</accession>
    <name>A0A6A6QUH4_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494567.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QVF2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_397044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
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    </dbReference>
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    </dbReference>
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            <end position="158"/>
        </location>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495703.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="559" mass="60712" checksum="2C7C1BE4F857BED1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVS6</accession>
    <name>A0A6A6QVS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU004190">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVS6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDH-like"/>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2495017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="52745" checksum="BC439DDEB5FEDC1E" modified="2020-06-17" version="1">MGIEKLNPKDYNKLFLNGQYVAAKSKETYSLKNPKDNTAVIDDVPIAGPEDVDAAVKYAEEAFHGPWSKFTAIQRTECFLKLAALLDEELTPILTLDSQTSGIPISLAPVRERGYIRNCVLYYAGWTDKQKGDYFPDDDGYVKLVRHEPLGVCCAINPFNAPLATLFLKSAPALATGNVMIVKPSEKTPLGTLAAAQLFLKAGFPPGVLQVITGAGSTGALLAEHMKIRKVSFTGSVTTGRRVQIAAAKSNLKRVTLELGGKSPAVVFDDANLENAVTWTVNSILIRSGQLCVAPSRVYVQKGIAEKFIDAYKKKMSAAADNLGDPQDPNVTMGPMVDAAQLERVKGMVERGKSEAELVVGGNQRGDTGCFMEPTVFLNPKSDAEIYRNEIFGPVSVIKTFETEEEVLKLANDTEFGLMAGVFTKDINRALRMSSGMEAGVVGVNCVSLQNMQAPFGGKKQSGIGREMGEYALRLFTEPKTVLINMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW74</accession>
    <name>A0A6A6QW74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_339613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW74"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="87" mass="10125" checksum="D829ADC39A29A595" modified="2020-06-17" version="1">MRIPPMLDSFWEGFSPSNSLPRLKPLSKAARCYAVIAVQFRPRSRRLLEDEIFTGHWGPPELLSRLEWPPPLNALRVPLAYKYHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX84</accession>
    <name>A0A6A6QX84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_549820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX84"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="250" mass="28019" checksum="078624F1384FD208" modified="2020-06-17" version="1">MDNVSSTRRPTYKLEVLGENPEDCTGLINQFILNHFVTTYDPTVDDSFRKEAIIDGQPSLVEVINSAGQGEVTALRHQWIRDADGFLVVYSITSRKSYLAVTKYIGHIHRINRPHYEMEGAVSRRIMLVGNRCDSRAIEREVSTAEAGLLAKRHGIGFVEASAKESINVERAFYDVVRELRKQRAASRLLKTGIASPPKKPKKSSQRSGLVKNIAERFSALRHGERAKTRVKATEDNSSTFGNVSFSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXB5</accession>
    <name>A0A6A6QXB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_581665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXB5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="13824" checksum="947C67D7363D6313" modified="2020-06-17" version="1">MPGGSPQGPLSAALCAGLGVCGSTSIAAVIQSKACNKDARLWGPRQGSLGVQLGMWDGDGRGVVRTSLANCAGDLSADKPISQMHLLAACTPLAASASGAPMSTAQSRGVRLNGLFCSYPGSAAESHPRSTGRFPPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYQ6</accession>
    <name>A0A6A6QYQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="55036" checksum="11C104CB05DF6E7E" modified="2020-06-17" version="1">MKRKSGPDGSPKLGTKLQSSNKRIARRQDNDARTEKPTSVNRANKLEQTPRRASERLRIVAKSKDDSKGYQGHRGSKSFVPSPKDRKPSHNDRLKPLRDAYAADRIASLDFARKFHSRLPPELRNEVYKELLPKKINVGRLSTKTTRNEIVDMLGHPRYCFPSYVGRDVAREALKDCYSNTLFIFTHNAHDRHNDDFHVKLDAGGLLWWFLHVDVFGLGVVPRNLIRHIELSVFVDRRDQGVTNARLDWIRREPSHPEEWIDWSQDLSNEDYEKASQELLEQAYIKHDHVRHYLGQFLKLSQNANLRVNVHSRLRRHASQTALEFRHVSPLLFKLRDKGWNVKVTYWDHAIRSNRAEPLDMTICFDKSTEQYRNKAYKVLQRMGLTSPPPEYLYEHNKSPLLAWYLLQLHDHYNVYVTMQGSKDDIESSEEVDTEQMDEDEWRGFCARTASEEMKRIKKRVNERKRFL</sequence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <location>
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        </source>
    </evidence>
    <sequence length="350" mass="37195" checksum="028E10432139038C" modified="2020-06-17" version="1">MPQETKQWLLASEPVADAILSGPDSTFKLVTTTLPALKDNQVLLHTTHLSNDPAQRGWIQRGQDPARSYTPPVAVNTPMRAYGVAEVIESTAAALPTGTLVIATVCWSEYAVLDAAECRVLTPTDGAKPTHFLGALGGTGLTAYYGLVDIARATAADAVVVSGAAGATGSMVVQIAKHIVGCKRVIGIAGSEEKCRWVESLGADVCVNYKAASFKEDLWAATEGFVEVYFDNVGGEILDLMLQRLKREGRVAACGSISNYNAGDKAAGLKNWFEITRNRLEVKGFIVTDAVVAGKTGAFTKILTAAVKEGKIKLGPEVETVIPTKFEDIPKTWVKLFSGGNQGKLVTQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0G6</accession>
    <name>A0A6A6R0G6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_331935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0G6"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF89">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="242" mass="26806" checksum="0FA91E45238C5A58" modified="2020-06-17" version="1">MAEQIASSPDLKPEYEPPADLKSRLKASYDAIAPTYNEWTIPHSATRLHYLDKLLSRLPTSTSTPVSVLELGCGYGVPVTQKLLSYPNFTVTANDISSVQIELARASLLPDPSGPAHGRLKLLECDMLALNFEPGTLDAVVGMYSIIHLPRAEQVEMLRKIVTWLKPGGWLFANFGAEEFAGAENQNWLKEEKGWMFWSGWGSEGTVEKVKEAGLEVVVQETQQDVVDGKVFLWILARKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0J0</accession>
    <name>A0A6A6R0J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_615293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0J0"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="465"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="567" mass="61637" checksum="7EF4FF35BEFA1FCF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0X7</accession>
    <name>A0A6A6R0X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_579553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0X7"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="529" mass="58849" checksum="5A761A9DDEF42A44" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R159</accession>
    <name>A0A6A6R159_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_615333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="423" mass="47507" checksum="5B1B4845A2FB2A0E" modified="2020-06-17" version="1">MTRLFARLGAGQHPISPREPHPLPANGATTSNVPTLSVAGAGILSGYQLLRRRALPGHYLRNVGSLALPTLAFLVAVEILDDEVCIRPTLVKEGIEPIRPPILDFNGKTTTDDFFMTGVISGLVAASFKRPFANITGWRRYVSLATIGGLSGFFLAHAYFGKEYRDAWEKRTLPALRAKIEKSLALHRRFPGDESTPDDAGPIVDPEGLDAVVPPMIRTPGAHDQIFGPGISPFFVGESGETLIDYAWEGKESGLRDCIQSLEQLKKTLVVEAEYLWLEIAKKEYMFYTEQEGTEMKETKARQLRVLEALHRHVYMEISRLDWLIANLKRNIRQLQAESHEWLPHQEHLSNPALHSPRYSAGYLRNALQKAWEKDSNLTASPGKRMHPAITGYKKEVEKEILVLDDLLRDFEKRVQDANNRSP</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 269.34</strain>
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        <subcellularLocation>
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    </evidence>
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</entry>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24541" checksum="F543A6B8C17ED1B0" modified="2020-06-17" version="1">MKPPAKRQKTAPVAEITFDFAAREEYLTGFHKRKLARAKRAQEEAAKTAKQEKVEARRMIRQQRKDDLERHVNEVNALLKKASGDMSEGGEETDDDENEDEWEGIAEELPPPIDREEEYIDEDKYTSVTVESVDISKSGFSKPEEEGGTQEVGDAASKDAESKKRVWTKDNPHKDKPKKRKVKFRYETKSERKVTRFKERSKNRSQAKARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4W8</accession>
    <name>A0A6A6R4W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_283007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4W8"/>
    <dbReference type="OrthoDB" id="3798631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="126" mass="14074" checksum="928F80AAE2CD6115" modified="2020-06-17" version="1">MYKLKGGTVPLPRWILVFRLLQLIFAVLIIALTSYSISINKGGPVRASLSTSIQLPTNTPTAPPRHYRRAHNRHLNRLPNPSLHRPPAHRATPHLRPPHRADRRRHRNVVVVGRVCGAGGVSADFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5I1</accession>
    <name>A0A6A6R5I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_558776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5I1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="67"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="615" mass="69743" checksum="151D2F1B17B221C8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6B9</accession>
    <name>A0A6A6R6B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_234290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6B9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="70" mass="7950" checksum="7E14455DE3A9F97B" modified="2020-06-17" version="1">MTTSRFINTYQGGQACNGGVVGLIYTRPTLRYPKHPLPPQRGPLISRASRKRPHERPIVPKNSQLSRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6R3</accession>
    <name>A0A6A6R6R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_238190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Non-reducing polyketide synthase; part of a gene cluster that mediates the biosynthesis of a yet unidentified natural product.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="369"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1655"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1791"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1286"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1731"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1735"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1755"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2500156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="2168" mass="234550" checksum="6BE0B3F1AEDB3844" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R744</accession>
    <name>A0A6A6R744_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short chain dehydrogenase/ reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_252157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2500588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="26362" checksum="506ED94B899074A4" modified="2020-06-17" version="1">MSPIMQGKVFTVTGAASGIGRATAVLLAEQGAAAIAICDVNEAGLKETEESCRKFDTKITTRKVDVSNADQVSGWVSDTVKEFGRLDGAANVAGLAGGDGETTVQTIEQRDWDRMMGVNLNGVMYCMRSQLAHIVKPGGSIVNVASAAGIRGLPNSAAYSASKHGVIGLTSSASGEFGRKGVRINSVLPGPIDTAIFRDGEKKGLFIEDVQAGATQLGRMGQAKEVANVIVFLLSDSASYVTGARWTVDGGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7D8</accession>
    <name>A0A6A6R7D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_283183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7D8"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="38"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="655" mass="73985" checksum="ABA7843A20E19E86" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7R1</accession>
    <name>A0A6A6R7R1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_570306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="68"/>
        </location>
    </feature>
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        <location>
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            <end position="29"/>
        </location>
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            <end position="140"/>
        </location>
    </feature>
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        <location>
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            <end position="692"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="829" mass="93525" checksum="15AC0D4AEC1AAFEE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Z8</accession>
    <name>A0A6A6R7Z8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">BU16DRAFT_570320</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R898</accession>
    <name>A0A6A6R898_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="281" mass="31944" checksum="1FD6AC81410FF298" modified="2020-06-17" version="1">MDKNFAARMALKQQVIDKVGPDALDCREGGLEGCIELLGILTEYLTRRFPSVFKLSEDGIYIRNAVTNETHRVVAPYDNHPLHVAGRLVEDDLNILTPGPDGEYVLSAVLSAFPAGFHVREKMGKPMTEIHKTVPTYKEKLQKAMNKYFDSVGPSKLVMRLNWSINDHEELFLVEGAHLYENDVPVVDTSIDIDQVQLRVERQVLRRLPKSGAMCMLTKTYLYRLVEIAEYPGFAARLAGLLHKLPTKFAFYKRKPVWGEIVLGYLDEMAKRHPAEFEVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8N8</accession>
    <name>A0A6A6R8N8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_283637</name>
    </gene>
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        <property type="protein sequence ID" value="KAF2501538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9W1"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="23760" checksum="51218797CDD53668" modified="2020-06-17" version="1">MAFKRKRSMSNDSPLSTSSCSSTSTCDPQSPSPPSRPMGSVMDFSSSFPSTLQWPSQPTASFPRARLSATDLSSRTRKRFRDNRPDVETIHENTLSLLFSAARAPHPSPTPSQSQPLTTKHEPTQKSTLHAFWALPAPRAPVFSHVHLDAHTGPNPPQQGLPCEDCDSALEAESMEIDEMGEVGDEFACAGCRRRVCGMCAVAGDERRCLRCVGVGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA09</accession>
    <name>A0A6A6RA09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_203659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA09"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2501598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="222" mass="24732" checksum="40CFEA2B95A293F6" modified="2020-06-17" version="1">MTSQLEKMNVDMKAAERLEATTSTGKTAEKDYESAKSAALRAKTLFEEVQEHRLELFNKALTHIQEQIKVTYKELTTDHLAPDGGRANIDMADSDEPYLGGLTYNAMPPLKRYREMNELSGGEKTIAALALLFAIHSFQPSPFFVLDEIDAALDNVNIARVARYVQKHAGPGMQFIVISLKAALFQESEGLVGVMRDQAKMTSRVVSLDLRKYQPNNVPIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAK6</accession>
    <name>A0A6A6RAK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_440643</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAK6"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="886"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1117"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDC3"/>
    <dbReference type="OrthoDB" id="3640436at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="131" mass="14608" checksum="A1C28C76AC3B0A2C" modified="2020-06-17" version="1">MCHCVQNLSPSCPHAWLELIDPCYPGQNLNTCPRFQDGSLSIVSRLPPFRKKWAPPGCCPRCNLGTYDGRVTKMIVRESHGCKLGRSPPRPPPRSRRGYGYGYGDDYGYGYRGRGSGYREPQYGGGCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDW5</accession>
    <name>A0A6A6RDW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">BU16DRAFT_499041</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 27" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1320"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1350"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1382"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1511"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1535"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1602"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="31">
        <location>
            <begin position="284"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="30">
        <location>
            <begin position="1687"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="507"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1412"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1462"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="28">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="1433"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1485"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAF2503048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1755" mass="194467" checksum="7E385AFC1C02F04B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REB4</accession>
    <name>A0A6A6REB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="267" mass="30918" checksum="516A49A01F3FDC4B" modified="2020-06-17" version="1">MPLNHLVFYDSNGKKLDLERSGFKEISAPDGIQAESRLHSLPREIRDMIWEYAWGGHVVQIRERAKTSRNFSLDNSLASIRQMHFDLHHWPEWDANRWTEIVSAIPGLKSLHLTITGSGCPLSLWEYFDLRQSPQIVDPTTDYTWPSALGHLATMLPAFQQLRLDEHRTTCTIEQLHGTPRRLSHRPHIILVMYGQTFWQIGPDVPYTVKDTRKLAEQIRGFLLRRVPDERAPNGTNDQGRVDELDFNSNIFFKILNTRLLTVTRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REG3</accession>
    <name>A0A6A6REG3_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_475667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
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        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
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            <end position="38"/>
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        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="538" mass="60752" checksum="509D790207FD514A" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF42</accession>
    <name>A0A6A6RF42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
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    </dbReference>
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        <location>
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            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="69922" checksum="5BA3F3BB3509E987" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFA2</accession>
    <name>A0A6A6RFA2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025364650" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36633" checksum="5F1E08D8454B4B83" modified="2020-06-17" version="1">MISKILITAALFGGAVMGAPLREKRQAAVPQFVLDYAPLVWLHSQEAYNPSDISAQLANTQPQHEFVAVAGPSPLTLDNLNQLNSPNTTYLTSTVDITTNPSFLKGVKPDGSGKTNGAVSAAIIVNDHGSGNVDAFYMYFYAFNWGGIVLGQNLGNHVGDWEHNMIRFKNGVPDLVWYSQHANGEAFKYSILEKHGLRPIAYCGNGSHANYAIKGKHDHTIPNLNLPDGLIVDNTDQGTLWDPTLSAYYYAYNPTASSFTPYDSSTPVNYLSYTGRWGDEQYPDSDKRQKKFFGQPKYATGPTGPADKQLNRTDVCPSNGKDCIHRGILVPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFG3</accession>
    <name>A0A6A6RFG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_10060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFG3"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="597" mass="63834" checksum="BE75DC5B91F5AAEC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFX5</accession>
    <name>A0A6A6RFX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_6836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFX5"/>
    <dbReference type="OrthoDB" id="10371028at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="204" mass="22761" checksum="47DDCC05B3CDDD92" modified="2020-06-17" version="1">MDPTTTNGGFAAQAPPPAFNSARPQAPKKLRNDKKRPVGRKPVNAKFISNEEVRDNIQTFVAAWNRFSEDEKTALQKVFSYNPNTLSAKTHAYVYGMPKKSLADRVTKPIVKDSAHEAEREARRAAKVEKRKTIRAQKEGAQAVAQQIQGNAQQVLATVQEPIPQESQSQQANYGFNPENFSVETVNKTTTETLDQSDIIDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG49</accession>
    <name>A0A6A6RG49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_448274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RG49"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <position position="450"/>
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            <name>Fe</name>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Liang C."/>
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                <person name="Mondo S."/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2502723.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6Q9A9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Arb2 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BU16DRAFT_567819</name>
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    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 269.34</strain>
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    </dbReference>
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        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
            <dbReference type="EMBL" id="KAF2488852.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="792" mass="89537" checksum="97C46D8E03012794" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAM1</accession>
    <name>A0A6A6QAM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_472487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="204"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="49"/>
            <end position="481"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="53557" checksum="FBE237EF6B28F1B0" modified="2020-06-17" version="1">MDLEKADAQQPIPAAPQAVEGPRSDLVDFDGPNDPANPKNWSKRRKWGVTLSMASLVFTVTFSSSIFSVAIGVVAEEYNVSEIVSTLGVTLFVLGFVFGPILFGPMSEVFGRRLPLFSGYIIFAIFQIPVAVAQNIETIMLGRFLGGFFASAPLAVVGGGLADMWDPIDRAYAICVFAAGGFAGPVVGPPIGGFITQSYLGWRWTAWITLIMAALFGTIALFVIPETSAPRILQTKARRLRFQTQNWALHAKADENRIDARQIMTVYLIRPFKMFFQEPILALITAYMSFIYGILYLLFEAYPVSFREQRGWSLGVSSLPFVAFIVGIAMGSGLIAYSTATNFTRAFVKHGRAIPEERLPPMIVGAIILPIGMFWFAWTSNPSISWVPSVFATAFIGMGCLVTFWQGMSYIIDCYGFYSNSAIAINTVLRSIAGAGFPLFATPMYHKLGVDWAMSLLAFLCVAFIPVPVLFYVYGAKIRAMSRFTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAV2</accession>
    <name>A0A6A6QAV2_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_180903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAV2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="14657" checksum="F2687A04A8EEFA10" modified="2020-06-17" version="1">MTAPCCTSHPVCVLDADSGRRLLGARSLGRCRCWSTRLSSECILASSLPSPPSVLTWALSQSCTHSLPTDPPNPTVAVAQLQTAALCSLPLLLLPPFAPLVCLQSLKGLVEKPPPPNLLALLPTTSTPPAAALRHASNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB59</accession>
    <name>A0A6A6QB59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_472678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2488863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
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            <begin position="122"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2488863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="723" mass="80794" checksum="C3069854E4828FDC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBZ5</accession>
    <name>A0A6A6QBZ5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">BU16DRAFT_531554</name>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBZ5"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="54224" checksum="3A046C0F00DBB4DF" modified="2020-06-17" version="1">MGNREGDHVLHAKIVLLHLVHPSSLCTSEEISSKSRHSGLLASLRTFHSFARVVLCLGRQPVARRSSHALAKLKPSAFSVRVSASSTTHSTWNHNHEKTTSPRPGPGRDASMIFRPLQIVWWAIVDGLLALHLAFPVLSYYDGHDRPTKARDAVLNSPELLDLILHQLGVPHVLKYKRICRAWKEAIESSPAIQHDLWKRPIDRDTATEFTTHDLLDLVYGGCRVCGISANHKAPSADNLNPILAPDLLVKRESWLGRLVQRWHLWRRLNQGCWSVQDDGSLLFSFIAPFPLPLLTGDLDLTTATWRDTLVSLPRVTKVTIRGRRIQIRHPAMPFMPRWKTQAVLENPNGLRMGELMDVMREMDEFMTLRGWVCEWRFVPTGFVLLGALLLLSLLWLSFWAWIFCNVTRWALPFIWVHALVPSVTMSWSYLQETLAMSFMSYFLTSIMWLCAMCYSRVRMAWLQRTSKATLTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC36</accession>
    <name>A0A6A6QC36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_622230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1470350at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="495" mass="56770" checksum="42E78B60FB1A77EC" modified="2020-06-17" version="1">MHWAQYANILALSIGAAMLYTVTYCIYNVFFHPLRSYPGPKLWASCFVPSAIHALKGRLPYAIKELHDKYGEVVRVSPNYLSYDSDQAWEDIYGHIKAKHTKTFEKDYSFYGPTPSGAPNIIMANEMDHRRLRKLQSHAFSEKALAEQEPFLLQYVTSFISGLQKQVSGSAKGVVPISMWFNFTTFDLIGDLAFAHPFGCIESGKLHPWIAVTFDYIKMMEFMRLTRIFPVIEKLLEMLIPQSLKDVRTNHAKWSADKAQERVRMQTDRKDFMSYILREKGEKGMSADELNESTLILVLAGSETTATVLTGMTYFMLQRPEVYEILKNEIRTTFKSSEDMSIVSVGQLKYLNACIEEGLRMFPPAPTALPRIAPKAGEVVCGRFVPEGTEVGVTAWAAHHSKRMWRDPDSFMPERWLGDPKYDGDHKKAAQAFSYGPRNCLGKNLAWAEMRLIMAKLLWNFDLELLPEDQDWMDRNKIFILWEKAELHVKLTQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCA3</accession>
    <name>A0A6A6QCA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_470940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCA3"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="421" mass="47030" checksum="336C45E26A911A15" modified="2020-06-17" version="1">MPPRLGHKKSRAGCRSCKARHVKCDENRPCGNCTRHGVPCSLLTWAPGGTQSMSSTPPSSSARGSMQADELGVTRPTPTSSLPINFVLNPVPGNAESHSEISTPDSFPFLTRFVNRAYYTESANWAQDLELMHHWTAFAAWSVPGNEEIKNLWKIEIPQLAVSHPFLMHQLLAFAAFHLAHVRSADQLKYSLIAAGHQNKSIRAMSKALPGLIPENSDALFITSTLMPLTAFASKTTDNPIDDIVSLFQLIRGNHSILSSAFIRILRGTFGPIVRTALDPPPLPLMVDMLLHVDQLTALLEDPDLEPTYRRICVEAIYNIRQATNHGDDPGDRPIRIAYTWPIKISSDFMLLLKRHDSGALAILAHYCIILHLNQEEGYWFIEGWSSRLVEEISRQIEPLWKPYIQWCVEYIRGQQGIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDB8</accession>
    <name>A0A6A6QDB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_530908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDB8"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="261" mass="29756" checksum="EA5F27AEE04C7A2C" modified="2020-06-17" version="1">MSWTGFKKGVNRATTQVLMKAGQVERTNDRDFETEHRRFRTMETAANKLQKEAKGYLDSLRAMTASQMRIAETIDAFYGEAGAKDGVSRSYKQAVTDLDAETIKALDGPYRTTVLDPISRFCAYFPDINACITKREHKQMDYDRMRAQVKKLTDKPDKDVTKLPRAEKDEQLAKAAYDQLNETLTTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDADTRDQYAQGQLDARVEEVLEEIRGLSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEY0</accession>
    <name>A0A6A6QEY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_426993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEY0"/>
    <dbReference type="OrthoDB" id="5424462at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="91" mass="9340" checksum="0D3A12F7D466922A" modified="2020-06-17" version="1" fragment="single">PSTSQTYIRSGIGGAGNWKRAASIPSALPVPQITTPRHGSFSSGVGGAGNIHSTSTRRGLSADEELAREHAIKRSARSGWHTGIGGAGNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEZ7</accession>
    <name>A0A6A6QEZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_565901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEZ7"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025574154" description="Protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2490978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="368" mass="41228" checksum="34DD486652725799" modified="2020-06-17" version="1">MIFIIGILWFSISVLCSTVENLSSNDFQRMIRENEVVLAAFTSKTVKLTDSFHNEFEQAARVLTSPLVMIDCAQEFNLCREYDVNAYPAVRLFRGSNESNTYRGPRKAPAIVSYMIKEQLPSVTHVDEDSIAEFREIDGVVIVAYLDPEDAELIDTFSTYAREHHDDFVFGIATEAQLAKVDGLPVPSVTVFKIREGDNTALNGRFDQDSLGKFLAMATPSVIGEITKRNIDTYMSAGKPIAYIFVNSEDDKVDLRRELTPVAKKYGQYMAFGLIDAAEYSHMATNMDLRPGIFPAFVIHDVRTNDVFPFDQRKMITAAAIEGLIMDMAQGKIKAGPVADDRPFEEGLFEVDEDGLDETNLAQKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF43</accession>
    <name>A0A6A6QF43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF43"/>
    <dbReference type="OrthoDB" id="10325910at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="395" mass="44486" checksum="EFC11A7470548E1F" modified="2020-06-17" version="1">MVTPNHVYWLPIFDNIPRDSIIHRQVVGHQGFFNHPVLILEFDEDPNIVCFLPLTTFRGNYGTGPTPFDIRVEYIAIQGLTSPPDDEVKVQVAPGSPQMVERTWMKMEVFRIEAVNLQQYLRKTVEIDANGMDVIRTRLRQLAITPGAVMQVPEETTIGIDSVLHTQIGDEREGYSILNHLAVVLEVNGGYARFLPITTRNISQAGISKGVQARGFRQQYLLISNTAVVGHDGTPVLNLDRISSPLSQDVYVKTGKSYWIEIGRLKYYQFPSVRLDPLSTRVLLNYYFPFIHDRTLGSYLGRAPSPSLDQLPSDLPRDQADMAPILQHQGGPEKPQTPPSAASLETRNPFLPVYPLESGPIQEVQQQEQAPNPYRPVFPAEEAEAFNPYRPVYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFE1</accession>
    <name>A0A6A6QFE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_470125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="30"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1031"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2580"/>
            <end position="2657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1063"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2490207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="2667" mass="291692" checksum="5286B3C5C0F58891" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFP5</accession>
    <name>A0A6A6QFP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_135521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="167809at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="57"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="31986" checksum="2F1B3FB48645F795" modified="2020-06-17" version="1">MASDQVKVIGGAETFWLYSETNGYDLTHPPTPVGPKVYHRISLKTTDSWAVIDPKKTALVIIDLQNYFLSAALGRPSDSPGLKVVDQLLEHAIPACRKAGIPIVWLRWGLTQEDIEGMPPTILRGFGLDDNFDNERSPPGLGTDIGPIQLDDGSTVEGGRVLMRDQWNSEFYAPLASKAEDHDIRIYKNRLSGFWGGTGVEDALRSRGIRTLIFSGCNTDQCVATSLTDAVSKGWDCLLLRDGCATTSPKFAQDSVEFNMGGWGFLLDCKDLADGVDGMQRAAPGVHKDENGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG90</accession>
    <name>A0A6A6QG90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG90"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="173" mass="19089" checksum="5DB8043C4BE517E8" modified="2020-06-17" version="1">MPHPRRPSLPQLPKPPHDRSFSASFPRATQPPPTVVPPSHTSSPPQPLPLLKSHMTLRASPEPLGVRSPNWQPPARSVLAQDYLDSRLPAIRQRIDARQADAQTNGREAEEELLGCLRGAVREMMGAERGFWVELEELATVAAATRFLLVDEALRGMGRGVLTGKERESLLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGH2</accession>
    <name>A0A6A6QGH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_143825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGH2"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF80">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="32816" checksum="AF319B43F2E1945A" modified="2020-06-17" version="1">MTTFTIDPETLTTLHHKTILITGGTSGIGLATAHLLSQLSPTNNLALLDLHPPPATFTHPPYHLLYHRTNVTSWPSLRAGFAATFTKFARIDLVFANAGVAEFAHQFFADTLDSSGQLAAPDHRTLAICLDGVADTVKLGIHYLRKNGGEGGAVVLTSSLAGYLASAGAPLYSAAKHGVVGLMRALKQETAKLHISIAVVAPAITVTPILSTGYREAGSDPADYAAAMAEKGVPINKVESIALAACWLFHEGMAANGAGIFVQADRMVDFERGLAKSREVWMGREMLDLFRGGRGAPLFQRLEGEKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGL9</accession>
    <name>A0A6A6QGL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGL9"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="502" mass="49779" checksum="3C5096319FA4451B" modified="2020-06-17" version="1">MAEPTPPLPPVSPDSGPTDPNLPKVPSGWISQWDNTSRKYYYVQIATGASQWDMPTSAAPTAPGASPAGTPAQGANPYDAPHQQQGLGGGEGTRGIDGQTGERSGGLGGMAMNMLSGKQSGGKQSGGQGGLVGSLASSFLGGGKQSGSGGQGGGGGGGLVGQLASGLLGGGKQSHGQTGGQGQQGHQQSGGLGGLLGGVLGGGGAHGQKPTDYGYSHGAGGNTYTGQAPPSAYQPAGQHGTPGYGSPAPSSTAGQYGSPAPPGHYPTQGQYNAPHSGHASPPAGQYNSPPPHGQPSYGGQASSYGAPGGHDQYGAQQHGAQQHGAQQHGAPPGQYNPPGQHGAPGQYNPPGQHDQHGVPGQYNPPGQHDQHGAPGQYNPPGQHDQYGSQHGTPGQYLPPGQAPYGAPNPSYGGDNHQYPPPPGQYNPGGQSHDQYGQGGHGGQPPQQQYGQGYGEQGHQQQGQYGGQGGYPGQGQHGGQQHGGQQGGYGSHGGTPQPPQPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH53</accession>
    <name>A0A6A6QH53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_139529</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH53"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="707"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJB7"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="389"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2492528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="730" mass="79958" checksum="0B3ED7900C0083ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJF4</accession>
    <name>A0A6A6QJF4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_105456</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
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    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="547" mass="60915" checksum="D825107F19E442C7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKP8</accession>
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        <submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKP8"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="504"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="65821" checksum="03C82EE2215EDD6C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKT7</accession>
    <name>A0A6A6QKT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_465838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKT7"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="264" mass="30003" checksum="879F04EA047053D9" modified="2020-06-17" version="1" fragment="single">MSRETAAIVTAVVLLAVSTTFVWCRLAIRFFMVRAPGKDDLFCFIAMVGGLWVENILCLLKIKFGSGKHIWQLSPEDIRNQLLAVFISQPPYILCLAFVKFSILCQYRRVFSTFIRRICLAMQVFVGVFTIAFCFLFAFQCTPVKGFWDVNARHHCYDLDTVQFIFVGINVATDLALLAIPMPIFRNMKLRKAEKRSLIVIFALGGFSAVTCLLRVPYIVLSTHSVDSTYQNHGLIIWSRVELNVAIFCACLPALRVPLARWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLV4</accession>
    <name>A0A6A6QLV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_80982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLV4"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="49431" checksum="9F8A0BD4CAF0660F" modified="2020-06-17" version="1">MAPKPLQRVVPHLRAVQYHNLHTFLSQPLAELSGSLGDLGTLLPLMIALTLTGSISLPSTLLFTGAANIYSGVAFGIPIPVQPMKAVAAVAIARRFSLEETAASGIVVAALVGVMSVTGLVRWASNVTPIPVVKGIQVGAGLSLCLSAGSSLLSPLSWTGPWWGDNLLWALLAVVLLLATLPFPRAPYALAVFVLGLVLAGFHAPSASPPNHSSTLPPHSNSSSNPFADIPILHPSAATFWHATTTAALGQLPLTLLNSVIAASALAVDLFPSPPYPTAPSVTSLGLSVSLINLIGCWFGAMPACHGSGGLAAQYRFGARSGASIIALGLLKVALGIITLWKAEAVVSILKGFPAALLGIMVLAAGVELAKVGESLNTDARDLRLMHGDEDGEETWDGKGVRSLDERERRERWMVLLVTVAALLAFRNDGVGFLVGLAWHLGFRATKSVEEWRARRQGRESVPEEERGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMU3</accession>
    <name>A0A6A6QMU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMU3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025675312" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19474" checksum="42DC3B58F9BF5947" modified="2020-06-17" version="1">MKVRGYLLLLRVLDLLFSLDRFGLGYFRLLAVNFTRRRDCTPIDPPNTPRKLLLLVPENVHEARRIPTSTKRVALEGVPDFPVLLTVSQLAHGSVQRCFPVRSNSAVSRRLCQSLLAVSAGHCLRSVPGPRRRANKSNVQEFPRRRFQTLSAAATIPKSDPADSAAGMCWGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN32</accession>
    <name>A0A6A6QN32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_583587</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN32"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="307"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2493496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="432" mass="45047" checksum="EFB079D31AB9F92B" modified="2020-06-17" version="1">MSSAAFRRMTSTTASTRLSAVQRHFSTARPAQKEIRDAYILSAARTPTGVFNGAFTTVPAPSLGATAIKAALAKTALPISKISAVYMGNVLSAGLGQAPARQAAIFAGLPTHVEATTINKVCSSGLKAVTLAASAIELGHADAQIAGGFENMTRVPYYLSRASQQPAFGDQKLADGLVGDGLWDVYNQIHMGNCAENTAKKFEIGREEQDAFAVRTYERAQAAWKAGQFTEEVAPVTVKGRKGETVVTEDEGYNKLKLEKLPTLKPAFVRDGTGTVTAANASAFSDGGSALVLASGEMAKEFGKDSRVLARIVTYADAAVDPIDFPIAPAEVVKKILAQSGLTKEDISVWEFNEAFAAVIKANAKIIGLTGDNVNPRGGAIALGHALGSSGSRILVTLVHQLEVGQYGVAAICNGGGAATGIIVQRVAHADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNF6</accession>
    <name>A0A6A6QNF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_438968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNF6"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="17753" checksum="6F965EA07A645EDF" modified="2020-06-17" version="1" fragment="single">EADRAEVERRRNLSAAEREAEDREFLRKQEDEKGERGTMAHMQKYHHKGAFYQDDLKAHGVDRRDLMGAKFEDATNREILPEYMQMRDMTKLGRKSRTKYRDMKSEDTGRWGDFEKRGPGKDYGVDERFRPDGPEGRGPSVTGANSGPLGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNH3</accession>
    <name>A0A6A6QNH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_59991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNH3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="18422" checksum="A99D220814A573E3" modified="2020-06-17" version="1">MGLTPLCKVAAVSGGSNATSKEFPCRGWGWRALQQARERGDRVKVGKKVRHGASTLEQEDPYVALENGTNCCTMVGGGVKPFAEMANGGSGVEWGFVESDDDVQRLVEVMIGASGDERGGGLIRSGGRDEARYVIVVSSTDKRIVVGWPFPLLFPDLIWRPENMRRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP09</accession>
    <name>A0A6A6QP09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_489344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP09"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="6"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="228" mass="25152" checksum="C699114547CDE37B" modified="2020-06-17" version="1">MSFTPALVIVDLQEDFCPPNGSLAVQGGRDIVSSVNHLLSLPFAVKVATKDFHPQDHISFASNHPPPNNKPFESTFTIKNPLNPEETQTTRLWPDHCVQSTPGSELIPELNRSKVDHIVEKGQDNRVEMYSAFADPFINPTVSRSRLAEILRDAEVTDVYVVGLATDYCVKFTALDSAKEGFKTYVVGDATRPVDPASLDDVYKDFASADVDVISTDSDEIKKVKQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPP2</accession>
    <name>A0A6A6QPP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_489211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPP2"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="339" mass="36464" checksum="ABEF461E431596BB" modified="2020-06-17" version="1">MRAIQVTEYVKGPEELKISTLPDPVPKSDEYLIAIHATATNFFDLLQIRGKYQSQPPFPWISGSEFSGVITKAPSSLPGGRAPKFKVGDKVFGASQGGYATQVAAPEDRLRPMPRGWSFFDAAGVFVTGPTSYAALVTRAGIKKGDWVLVHAAAGGVGLAAVQIAKAFGATVIATAGTQHKLDVARSFGADHAIDYRQSDWPEKVKKLTPKGRGVDIVYDPVGLIGQSMKCIAWNGRLLVIGFAAGDIEKMATNRILLKNVSVVGLHWGAYSINEPEAIEKVWEGLYELTESGKYRGTCFTDKEYVGLESVPAALQALGGRESWGKVVVKIPQEGQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPQ8</accession>
    <name>A0A6A6QPQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_619472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPQ8"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRS0"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="568" mass="62085" checksum="17AF4D002B1F4987" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRU6</accession>
    <name>A0A6A6QRU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRU6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="10362" checksum="1B530329E372D803" modified="2020-06-17" version="1">MPSPRGKQQNNLPRSTLHYPPFLPRDAAHPLPPPQPAPFPPILLLWWWHKLDPPLGGIPLTNPPLPPNPRHLLPHLLNRPYTTLKPWRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSR6</accession>
    <name>A0A6A6QSR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_562904</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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        </source>
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    <sequence length="1764" mass="194113" checksum="FA09D44736E4F33C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT55</accession>
    <name>A0A6A6QT55_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="494" mass="55825" checksum="F05AC0711287A739" modified="2020-06-17" version="1">MEVDQPAVNPDQPVKDIRSNFALLERAVAQFDSRFTLRALRSISSIRKTLDGRILCSVIVLTYLPSNPTARILIEATGLEGEEISRVVSQYKEELAILKANPKEVIPEIDVYIAILIQVYLYDTKEFDDGAEFSSTLVDKIRELNRRTLDSLAAKSYFYFSLFHEELDPKPPSKQSPVISIRGKLLAALRSSVLRKDQDTQAAVTTLLLRNYISTADITQADLLVAQTQFPSTAPNNQVARYLFYLGRIRAIQLAYTEAHEHLISATRKSPTNAVATGFYQASTKLLIVVELLMGDIPDRAVFSQPNLERALEPYFRLVQAVRVGDLQGFLKVVQTYSSVFHRDGTYTLILRLRQNVIKTGIRMLSLSYSRISLRDICIRLGLESEESAEYIVAKAIRDGVIEATIDHEKGYMQTKQAGDVYATREPGEAFHDRIRACLSLHDECVKAMRYPMNQHRLELKNAQEARERERELAKEIQDGDIDEDEAAGDYDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT60</accession>
    <name>A0A6A6QT60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="128" mass="13482" checksum="6842DA08282AC779" modified="2020-06-17" version="1">MVVSSLVAAVTSHTGAASTPHWQSGGDGLHASGIAGPNASASSGLTSHRITQRSTAPSKAKRNLPQPAARCHKRPATARPGCTLRERHHGSHSSQRAFAEALHTPAPHPVLHRRRLPLEGLKYATVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTW2</accession>
    <name>A0A6A6QTW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_460554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTW2"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="572" mass="63110" checksum="498EC0F8DA727525" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUK3</accession>
    <name>A0A6A6QUK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_539365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUK3"/>
    <dbReference type="SMR" id="A0A6A6QUK3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="571"/>
            <end position="572"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="666" mass="74547" checksum="E6250354C0FC89FE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUY8</accession>
    <name>A0A6A6QUY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_527736</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUY8"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:FMN binding"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="692"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2494747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119589" checksum="4487446A2B258F14" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV25</accession>
    <name>A0A6A6QV25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_526327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV25"/>
    <dbReference type="OrthoDB" id="3913903at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="27945" checksum="0317D772AD41808F" modified="2020-06-17" version="1">MAATAKLAPTFPWDHDIPKTPFWSNIEYTTARNFLQCFTEGELLQKQLDDALPLRGKLESLEIFLDESLEAREYASRPQSLHRADYQLWMKLKLAQSSIAKDLEKRQEQEKIVREMYANGPYDPVSGTNTKNMSALLNLSGVLEYDGLHAEAEAAAREVLPWLQKHEMLGADAPQVLSCMRTIARTTGKQRHWSESNLWAGKVEELIDGMGGRRFAKYEEDERKCLEELREELKAWKGDHKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV40</accession>
    <name>A0A6A6QV40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_509219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="10"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV40"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025647700" description="glucan 1,3-beta-glucosidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2496291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="32231" checksum="55FDCC1919B38F1D" modified="2020-06-17" version="1">MRFSILASTALVAAPALVSAAGTLGFALGTKKADGTCKSQSDYESDFDAISAASGSKLVRGYSASDCKSAASIMPAAKSKGFQVVLGIWPDVQSSFDADLSAITGVAGKYADSIYGVTCGSETLYRGNFTGEELADKIKTVKTALKGVTSTPIKVGTADSWNKFADGTGDAVVGAADMIFVNAFAFWQAQGLDNATNTYFDDIMQAFGHIQTVAGGPDKAPELWNGETGWPTDGGSDYGAAKAGTTNAKTYYQSAICGMLAWGVNLFYFEAFDEPWKPDSIGDNGKPADETHWGAMDANRGTKFSLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV41</accession>
    <name>A0A6A6QV41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_526589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2496056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="526" mass="59175" checksum="A2CEA58B0108E814" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVI8</accession>
    <name>A0A6A6QVI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_562000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="617"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="845" mass="93964" checksum="D224EB4155C97602" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVK5</accession>
    <name>A0A6A6QVK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_526463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVK5"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2495930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="23271" checksum="AF5DA4C585D9112D" modified="2020-06-17" version="1">MTDQPVSQPAGADPNAEITDDIDRSIEAELNPNDTQADPMNLDGANDLEPSTSNGAGVGAAALEARISAKKDATLREFLGKMDEYAPIIPDAVTNYYLTLAGLPPPPQTSPHLARLLALATQKFIADIAADAYQFSRIRASNTTSNNPMGGLAGAAGTGAGPQGAAAAGGAAGGKEGGPAGKGLNLGVQRPGYGGGGQGGSQGRTVLSMEDLGMAVGEYGVNIKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVM0</accession>
    <name>A0A6A6QVM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Short-chain specific acyl-CoA dehydrogenase mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_617658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVM0"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="160"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="268"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="445" mass="48530" checksum="1CAFA9D28B7A1119" modified="2020-06-17" version="1">MSAITNPIVPFSEPPYLAGLPSPYYTESHLRWQQACRAFIQENLIDQALEWDTNETLPESVFENFAKAGMLIPSLPAPLPVEWLKKLGIHDFLGVLKVEDFDYIHTMIYCDEMARSGLAGPSGSLTTGISFGVPPILKFGNAQLQERFLPDLLTAKKRTCIAITEPGAGSDVANISTTATKTPDGKHYIINGTKKWITNGIWSQYSSMAVRTGGPGPSGLSMVVVPLLGYPGVTMRRLKVGGQISAGTTFIELDDVKVPVENLIGDEGMGMKYIMTNFNHERLTIAIGATRQARVALTSAMEYVMKREAFGKALVEQPVVRHRLAKCGAMLESQWAWVEQFVYQMTKLPKATADVELGGLTALVKAQSGIVLDECARCAVLLFGGNGYTKSGQGALAERIYREVPGIRIPGGSEDVMLDLAVRQLVKNFKNKTKAMEIPKGSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWK7</accession>
    <name>A0A6A6QWK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_616658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWK7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="597" mass="65011" checksum="4F04BC0EA1523C1A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWY2</accession>
    <name>A0A6A6QWY2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">phosphomannomutase</fullName>
            <ecNumber evidence="5">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_525760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5"/>
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        <property type="reaction ID" value="UER00424"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IIB"/>
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        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="PMM"/>
    </dbReference>
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        <property type="entry name" value="PMM_cap"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="225" mass="24518" checksum="4E64588848F59985" modified="2020-06-17" version="1">MGEALADLLAVANVAVIFGGDWSQFRKQVASRLPARADLSKLWLMPTTGTKLYTHKNADWQAVYAELFNDDERKKIIAAFEASLEATGFKPEQTWGERIEDRGSQITFSALGQEAPVAAKEIWDPDFAKRKVIQADLHTRLPDLSINMGGATSIDITQKGVDKGYGLKKLRDASGIPLEHMMFIGDAIFPGGNDYPAKELGLETVRVKDPDGTLAAIAAVVACLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY86</accession>
    <name>A0A6A6QY86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_340706</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY86"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
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        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="101"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="403"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="742" mass="84709" checksum="71916DF32747C716" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYF9</accession>
    <name>A0A6A6QYF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein DML1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_342547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYF9"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="524" mass="58397" checksum="97D2AEFF4B9B30F2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYK9</accession>
    <name>A0A6A6QYK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_458257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYK9"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="384" mass="41561" checksum="D6D860663F66669B" modified="2020-06-17" version="1">MLNVKDTQLALIHIPLSLYANFLQAILQLLLPNEGRNDLASSNGAVRAPRGWPYEHPFVNISITHIECSVVCSRTLARELFAPVRDSLDAAARNQVSITTEDFIVMQVDGEGLDAGQRVLELTSPLALAGISIFFITTYFSDYILVPLRCRGQVVHALEERGFAFEHHTSTYVNPSHHRRNHSSTSSFDTQAPGTPPPATISELQIRTFATLKRRNIVPTVNPSLRLIQCAGRKDPSRTGSSNGNRSSTTSAADDALHLGLVKCLITPPCPRFLSLTLTDTEPASLLLDHTLLPNFAQDVLLGSKDDFLIPITLDLRELPLESTGIVCGVAGRLVGGTAQGALENSVEMSYLSTARAGTVMVGEDELHRALAALRGAENGVVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYM5</accession>
    <name>A0A6A6QYM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_317509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYM5"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49329" checksum="3E4033947240833A" modified="2020-06-17" version="1">MTRLTQAGHSFSATSNDDVIGLTKKDVEQVQGKVAAHLDSLSEGKHKPFTKAEIDESAQRIRTELIARPAAFYKSDQFRKAMVTAIADYLNSLDCNPGQPITAALIQNVLTSNGRNYLNLCARLVSLGVMGASEDEIFNLNNAIQAAEDKLWLTRKDATSTRETSTENGSSPKINMTNLSTKAQPDVDTQPKIDTKPVVPTQPTISTKPVVQTKPTVGAQPSTPVKAALRGETSASAAPSGIWTPKQDIAPANMAAWPSQQKRENRAQHRRAILKGIPSDWKLDQVQAHIWGGRIERIERTADSSTAWVKFMTMEGYNKYFADTANGIEVAGSTRLILAEPDEGPNSTNDLLSSMVESGVTRCVRALDAEEDWSMPTLTRIARGKDRKLDKIKIGKEKGRNFVEFRFSSVYEALVFKKELMDDEDWEPTTIVYAPDPCDVHSGIHLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYM8</accession>
    <name>A0A6A6QYM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-binding cassette protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_482288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYM8"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="122"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="460"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2497366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="710" mass="80793" checksum="2B0A2C7C49E39355" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYP7</accession>
    <name>A0A6A6QYP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intermediate filament protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_485686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYP7"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="103"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="421"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="870"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138343" checksum="4DA9BD01FEE1619B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZN8</accession>
    <name>A0A6A6QZN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_537341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZN8"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64555" checksum="4B86891C40ED0E4F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0C4</accession>
    <name>A0A6A6R0C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_480955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0C4"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="274"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="398" mass="41152" checksum="93679F2839F2DFEA" modified="2020-06-17" version="1">MAPPPPVYIISAVRTPVGMFQGSLSSLTAIQLGSHAIKAAVEKAGIKPEEVQEVFLGNVLSANLGQNPARQCAIGAGLEESTVATTVNKVCASAIKAIIFGAQTIITGNADVVVAGGTESMSNTPHYLPNLRTGVKFGDHTLVDGVLKDGLTDAYKKEHMGLQGEECAEDHGFDREAQDDYCIRSYKKAVSATEAGLFTEEITPVQVSGGRGKPLVTVDKDDEPKNFNESKTKTLRPSFKPNGGTVTAANASPLSDGAAALVLVSEAYLTKHKLTPIAKILGWGDAAQNPSKFTTAPALAIPKALAHAGVSQDKVDAFEINEAFSVVALANMKLLGITEDKVNLHGGAVALGHPLGASGARITATLLGVLRQQKKKIGVAGICNGGGGASALVVESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1R6</accession>
    <name>A0A6A6R1R6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_548882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1R6"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="79"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="370" mass="41729" checksum="7A3182DD44BFA5B2" modified="2020-06-17" version="1">MTTFTTTQEATNVEGQPIKLTVAYDDKVHKESKYAAYLPVYDNTTKFPPTEPFEFHDRGHNADPAKPNLLNRNDPAVKTSKLTPRVGTEITGLQLSHLTDAQKDELALLIAERGVVIFRDQDFKDIGPDAQKEFGKYFGPLHVHPVGAHVKDHIEFHSIYLGKDNLYRLGRSQTKLTTTGYHSDVSYEHQTPGITILTLVQVPETGGDTGWVSQAAAYDRLSEPLKQFLEGLLAEHSGFPQAENARKDGHFVRREPVKSYHPIVRVHPVTKQKVLFVNRGFTKRIVGLKEEESDAILKLLFKHISQSQDIQVRVRWDDRTVALWDNRVTAHTAISDYDVSDEGEGLRQGFRITTLADKPVGVNGLESRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4Y1</accession>
    <name>A0A6A6R4Y1_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4Y1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="13271" checksum="D35CA4CD5F39A2B0" modified="2020-06-17" version="1">MSWTGSLQKGDITDALQDHPSLSLDRKIAKSKLSLVKRDDPYYIAIPKDSEDYAQTKATREFLNSEVKNPSKEIVEIHLPGTGHVIAWGCLQLTGEAKVEVEGYIGVEAPLGDDSEVWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5N2</accession>
    <name>A0A6A6R5N2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_305091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5N2"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="189" mass="21383" checksum="2BFF6556CD866C3F" modified="2020-06-17" version="1">MDVRKWLDEVVHPEKAASLPDQLGLPQFLHPKRDRQDPSDQAGAPAPARKHGRKDRSAASDSSILQARQHRTRKDASEHDAPVIAGANRASSPAEHRSDHSSSVSVASDHRYERKPRHKTRPDLYEPKQDASNERGSRKHRRGKDESRKEKRKSRRKKTDNPGAGLVQSFHANNVPRDRLTVRAHLHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5X7</accession>
    <name>A0A6A6R5X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_239266</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5X7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="9769" checksum="74D992D8DDC1C70F" modified="2020-06-17" version="1">MAKKTGKGLCSFSISIHISRQHPLRLNIAGSGTIDAVSPPTSFACAWRPYPPGLDRGVSPHHPQRQDHSMPPTLASHAAFALSCCRRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6H5</accession>
    <name>A0A6A6R6H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6H5"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="66" mass="7454" checksum="BE6F6D8C9DFFEFBB" modified="2020-06-17" version="1">MDVIRGALGFGIAEYATREQAEQAVNTLSNQNLMGRLVYVREDREAEPLVILHIFWNGGWEECGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6I2</accession>
    <name>A0A6A6R6I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500189.1"/>
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</entry>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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            <dbReference type="EMBL" id="KAF2499117.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <protein>
        <recommendedName>
            <fullName evidence="5">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_523378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7M8"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025421171" description="MFS transporter" evidence="2">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16495" checksum="34029F6D177F16AC" modified="2020-06-17" version="1">METRRSWILILLAFLALTLISSVSAASPTSFCKCTCNGNSTIVALDSPATKKPVDPDLLRERASRRTCSDCNRQFCLGYPFCQGAPEEEVFTTCFQRDSTKDQAVVFIFIIATVGLLTYAAVRPWIDQWSEKARERRDYIPVGSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7P0</accession>
    <name>A0A6A6R7P0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_558157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7P0"/>
    <dbReference type="OrthoDB" id="3800265at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="40012" checksum="F68C4A67644CA9C6" modified="2020-06-17" version="1">MATEMNSLGHHSSNSACLLLYTAHALTQNALHRGYLDDRSIMTFATALGELLVVTNEDSITIRVPQGATVKSRNGDEPALPLQEARDFIVTGSEHIAFLSQDSQYTALGSAYIRGVGSRVRLVAMQSPAAVVVECGAERLLARASGTRQITIRQDSSGEDGGLPAPQQQIIQEMLERIIREEVERSVNLRAGYSEAVSRRIRRQAYLETLRQLPNNAEQNAHQIVESMRHTDIRYSRAIENGMAANDHRLTIATIRHTLAEQRVATLEAERQMTMDRIRARAALAAMFQGGNRTQVDMQTFTSSLGACPICLEEYSSTHEPIILDKCRHIFGSECLQNHVNESALGQRHLCPTCRTVMFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Q3</accession>
    <name>A0A6A6R7Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_602657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7Q3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="409" mass="42742" checksum="18F32DA0CB6E2D15" modified="2020-06-17" version="1">MPTSKPLCVGELTTTFDAPYACGNAWIASTSPPSSTSTALFQAFIGSLFGIEAAQNCSPPRTTDAANNADTVYLRYYSPAACPLGYSTACDPSLGVSEFPAGLTMQICCPSGYSCPQRRSSNIGCVSDLPADQTAFYAAPLVLSLTESVRQGTSKVATTLAGAFGLKVVVYVLPSSVDIGSGSALTPGGHEESYNGYIFSLDQSSNLWIDGTSYSLSFPVTTPTTITSSVTTTGGFYAYDNITAIYAAGVTVAWQATDIAVLDLFQSAASAGSTSNIAGPTTTNLQAVNLVSPGLSKGSIAGIAVGVICFVLLLLLGIGMYVRRLRHALKTAKSTKSESENGKPELDGAEVNYQSLNSHEMDSPPAIFYELPTHERPVEVGSESLVRGSLGHVIDDESELVEGTQHRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Q4</accession>
    <name>A0A6A6R7Q4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_452632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1149"/>
            <end position="1167"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1173"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1285"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1413"/>
            <end position="1431"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="364"/>
        </location>
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        <location>
            <begin position="816"/>
            <end position="1056"/>
        </location>
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            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1442" mass="160029" checksum="A4792369C64DEFFA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Z5</accession>
    <name>A0A6A6R7Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_277491</name>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="177" mass="19833" checksum="860998F1892B2ABB" modified="2020-06-17" version="1">MPFSHGICKHRGFVPLPEEASYGRLMLGDYRLRSTLSSVHHILAAMSLSRLFWRQWPLHTESAPESEADLAASASLGYVDASKMHARQSENSRSIRVTLHFLSHSFPFGSLGYMTLPRMITMFSRPALQLLAQANHCKLIPIFYIARGSDHLVDLTRHEALHYAGSSRKTLQSPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R832</accession>
    <name>A0A6A6R832_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_479369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R832"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="587"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="885"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2500741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117482" checksum="BBBFF7627D148B6C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R884</accession>
    <name>A0A6A6R884_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_523454</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R884"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="186"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="297"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2500686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="554" mass="60260" checksum="3A4790732F10BB9C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8A9</accession>
    <name>A0A6A6R8A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_557980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8A9"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2499667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="37368" checksum="07659802BE1558AE" modified="2020-06-17" version="1">MSNSPELVVPGNAPVSAGRVSETALIASLWAGVAVSFVFLTARICIRLKVWHRLQPDDPFVILAWVLSVANAAIWTHVRKELYFDLALATGQVNAIPADFLERVERLIRGNLAAYILSYVSLWSIKISFIVFFRNFGDKLLNQRITWYAVLGFCVASFMVCIGTIDYRCLTSSGMKMISICMEPRTTTFEFVTLRLTTALDVLTDASIILLSTNVLWRIRLKTWTKLALFGIFSLTLFVIIIAIIRIALAPQHGKLDLSWLVCWSGVELSVALIVVSLASFRILYVSTQQSSRQALFQNYQAGEGSGGSRTKTTVITSEGEWTELGDVRDGGLGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8B5</accession>
    <name>A0A6A6R8B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_236090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8B5"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="49823" checksum="20464BA163FB07A5" modified="2020-06-17" version="1">MADTEPSYIDYEAFLDPSFSATSFANTLVLSTNNPSDTPLDLSTPLSRVLFDVQEVDTHIDTLTTKSALPLLEHTKDQSESSGRILKEVEGQVASLTESYKTLEREVVERYEVAEQVRLTAERLCQTVKIGRAVARCLMLGRQLEVQMAELSSSGAGATKREDHRAMVRSSNTLLSLRQIFLASKPGEEGEDLDRINVITTLKNEMVVPSERTIISRAQQVVREFSMSSLLASNSSSGQSSSASTYAQTEDTKSRTTSALLALYLLSPTSANTSVDQFQPALLINALQDYLQTALKSSHAALSRALATLPSLDRALLEISARCQNIVALEALLESTKQPVHPLLEPSTPIEEKKRSTDFLHPLLLSLDTSSLPSYFWRSLASTLSPRVQEILNRGGVSARTLRSNKDRVRDAVRECVNRGSQLPAGPLSRGKTGLAGNWEREAAVMVGSIVGVMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8F7</accession>
    <name>A0A6A6R8F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8F7"/>
    <dbReference type="OrthoDB" id="3800526at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025420282" description="Alginate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="86975" checksum="D9C4188FF6901B12" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8H8</accession>
    <name>A0A6A6R8H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_577217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8H8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="35263" checksum="562FDB1CF4B6E84F" modified="2020-06-17" version="1">MGLYRAAYSQLFPPKPTFTEKDIPAGSQVGKVFLITGANQGIGFELVKLLYHSGATIYLAGRSVERLNEAIEIITSISPAPEIPAVLKPLLLDLNDLAAVKTSATAFAAQESRLDVLWNNAGIGGAPIGTTTKQGIEGHIGVNCVGPLLFTQLLYPLLQAAAKSSAKGSVRVVWTSSPIVDMGAPKGGIDFKSIDSGKTMNSNRDYSCSKVGNWFLADEGAKRWGKDGIVSVVENPGNLNTSAYRYQSGFMMFFVKPILSEPKFGGYTMLYAGFTGDVGLESNGAYIWPFGRKIRNVREDIYQAIEEGKASEFWDWCEKKFEAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9F3</accession>
    <name>A0A6A6R9F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_500097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9F3"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="226"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2501181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="611" mass="67449" checksum="F9D16B4BCB8AABAB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9M1</accession>
    <name>A0A6A6R9M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_451603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9M1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="405" mass="46451" checksum="D4F816F755D489B3" modified="2020-06-17" version="1">MAYQRYPSRYGQCDSFFVDCPDEGLYVQRAAERERARSIAKMQQRVIQEDLSRMTREEYQEDILDHMEHMEGQTLPDVNSIDIQTEIQWFMRPYLLDFLVEAHAAFQLLPETLFLAVNLLDRYCSRRVVYKRHYQLVGCAALLIAAKYGDRKDRVPTVRELKSMCCSLYDDEMFTQMEWHVLQTLNWIIGHPTVDSFLQLALSEVEHDPEVEHMTLYIAEIALFHKEFVSTRPSVLARSSLALARCILSRNQSKSSDWAGAYDPSTVLNLSNHLYQPSQVLSRKYSIAPLSQVSLTVDEFLQRQAQIARRANAPPTPPASVHCEEPKPTTDVYIGPQTPQKHHYGSAIVNHGVLTPPVTPENDQFDGGKCAGLIPRVYPTTPTPVSNAQHVQPQYYQNQYIHHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA41</accession>
    <name>A0A6A6RA41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_253507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA41"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="408" mass="43379" checksum="66A56F0ACF59FDAF" modified="2020-06-17" version="1">MSDLKIPSSILIIGSGVFGLSTAYELCLNPDFKDTSITLVERRPFPASDGSSIDSSRIVRADYADPAYASLVSSAMPLWRSTWGEDGRYNETGLCLTCSTSAASYVQGAAAMMQSLGAPITLLNSPAEISTACGVDGCSGTSGYLNRGAGWVDAEACMRWLHSQVVALNRVTFITATVSRLLIDHSSARVSGVLLGPSNTPLTAALTILAAGAWTPALLDLRGICTATGQVIAYLPLTATEQTALATTPSILNLSTGCFSITPSRRLLKIARHGYGYTNPVQIPHPEYTPASTFPSQTTITVSQPLTAVDDPSLVVPAEGLAACRAFLREVYPSLAERPFSSSRICWYTDTPTGDFLVDYHPKYQGLFVATGGSGHAFKMLPVIGEKVVQCILGKTPAEFMEKWACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAV6</accession>
    <name>A0A6A6RAV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_547561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAV6"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.400.10:FF:000001">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="707" mass="78354" checksum="BF1831934180C933" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAX4</accession>
    <name>A0A6A6RAX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_535405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAX4"/>
    <dbReference type="OrthoDB" id="10521682at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="20293" checksum="EB8023A673D0D5C2" modified="2020-06-17" version="1">MPIPIYSPNGQPGFSPQIAPPPGRAPNTLNPHLHPAPHGFPPAMGPPTQTLTYRVPSHSSQPPNLYRHPDPINPTLGSSMMRRRPQWNQTHMHHHQTQWDLSHRRFQPSTTPFNSPGNYMRMKQQFHPVPGHQQPQAQARPQPLQGYGPPASGAGPGSARSQEINRNLGWPIQGSPGGVWGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBA6</accession>
    <name>A0A6A6RBA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBA6"/>
    <dbReference type="OrthoDB" id="5334244at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="16688" checksum="D7E3E41B4C8409AD" modified="2020-06-17" version="1">MSVFRQPARLGSSFLRPFLRTSPRTTFQPSHSRLAFGDYGSGDGSPVGENPKDQGTSRPSRDLEHPGAKAPDTSSSKGEDSKESKPSSSSSSATDSGEKKQGKGPQPKIYSERPPAEETDDVKQHNEEMKNRHDKPKEQTTKDNLDIGSKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBC3</accession>
    <name>A0A6A6RBC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBC3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="137" mass="15534" checksum="E8D065D79AAC20E4" modified="2020-06-17" version="1">MSAAEAWVRQRKWAHSFLMQAAATQYKGIMDFEYKHLLFILLSDPDNFSFHIENANSKVMCTTLMSHESSTRRHENSSGSTAHTAWSTRPLQENATPPPAPSSWSNTLAYDDPSPSSEMRFSAWRLRRQMSPNGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBS1</accession>
    <name>A0A6A6RBS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_2510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBS1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="162" mass="17897" checksum="67F358FA1945051E" modified="2020-06-17" version="1">MRRPAAGRDSASPHRSSKNLLSCRLRGFRRDVRMGLFVDRSYPTPNTRAGEATRAAGMNSTTTCRASNQHGLHFKMPNDLIYIRKQPDVEAGAWIRRLPNGDGRVPYVVLIHDAIISLPTASDRGVGGKRPAWNQFVFVERCMVRSVLASCLLIIKSGCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBW7</accession>
    <name>A0A6A6RBW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBW7"/>
    <dbReference type="OrthoDB" id="10317263at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="21301" checksum="C7AED6827FCF72FE" modified="2020-06-17" version="1">MSTLAFMDDCEDLYNEALFADMKIRIHYQGKVKEIYAHRAFLYKLSGMFRKWSIAPSKDPHENVFEIKNHSLSIVEKCIRYFYTDRYPPALPTDTNGNKLITHILISLWAQEYKVPRLQKASAKVYRKDLSACSLSEIQKFATTYRTLYEKNVDINSPIGRVITETLLRGKESFSPAPSQCVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCJ8</accession>
    <name>A0A6A6RCJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_554341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCJ8"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12698" checksum="E94029EB9A4EB771" modified="2020-06-17" version="1">MCGQYLPILTQLISAKPVLEIGTLGGYSSICFASASAKVTSIEIDPKHRIVAIENVRGMDVEVLLGAALEVLPKLVDEGRQFDMVFIDADFDDQLEQFDWAVKLTRRKRRGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD58</accession>
    <name>A0A6A6RD58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_533007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD58"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF4">
        <property type="entry name" value="BLR0106 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2502675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="47826" checksum="49B64FB4F5F8B86C" modified="2020-06-17" version="1">MAISHKTPGFSKVIVVGAGPAGLLLSILLAKQGIPVTILEMGDKLDENPRATHYGPPAMHELNRAGVGDDVRAKGFIPGVVCWRKMDGTVLAGIDGSVMDGDPDRMVCLPLNKLGAVLYEHVTKQPTAKILFKHKVTGIGQDDDKAWVDVQSPDGESRIEADYIVGCDGANSQIRRSLFGDSNFPGRTWDEQIVATNTYYDFTKYGYEDANFIIHPEHWHMASRISNDGLWRVSYGELPGLSREELLARQPMKFKTMLPGNPEPSDYKLASISPYKIHQRLAERMRVGRFLLAADAAHLCNPFGGLGLTGGIVDVGGLYDCLIGIYDNVAAPDILDIYSDVRRKLYTCIVDPLSSENIRRLFAQDPEKALETDEFLKLCQRTATDADFSREFQAGINALKYDFTKHYNNSTGAKDAAVVGKEFTSPALVAAVGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDH7</accession>
    <name>A0A6A6RDH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_556272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDH7"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025600934" evidence="5">
        <location>
            <begin position="20"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="451"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="622" mass="67818" checksum="98A8D3D962F74784" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDN2</accession>
    <name>A0A6A6RDN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_599985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDN2"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="34679" checksum="441D64F3F649BEA1" modified="2020-06-17" version="1">MSSTKLFENDLKRPLPKVEVFDSASVSPEQIVAALTKAGGCVIKNAVSPSDLSLIQKDVQPFLDADKPWEGDFFPRETRRVNGLAAKSKVFMEKIVCYEPYQSVCSKLLSSTTKNYLGQDLQVSTSQPQLNNTIVFAIGPGAKPQPLHRDDMIHHRVLKQMNAEDYVIGQDTGIGFFVGGRKTTKANGATRFIPGSHLWDHDTPPSEDLTFYAELDPGDAFVMLSSCYHGGSANTTEDEVRLVYSCFMTKGYLRQEENQYLNNDPEKLKELYDDTMLRLIGYNLSAPFLGWIKEGHPLAALGRQQPLGDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE47</accession>
    <name>A0A6A6RE47_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_475285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE47"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="3">
        <location>
            <begin position="339"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="4">
        <location>
            <begin position="571"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2502841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="72038" checksum="B4F8C5A817B3CD88" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE89</accession>
    <name>A0A6A6RE89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_521699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE89"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025595395" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7045" checksum="8164AF4591E193AD" modified="2020-06-17" version="1">MILHAALLRTLVRSLAAGPPLCRHGIRTPETVPLSASSKTPISSILCRTTPTTASVNNPYLPPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RED4</accession>
    <name>A0A6A6RED4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RED4"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="223" mass="25011" checksum="57F860175951383A" modified="2020-06-17" version="1">MSGLTVWALETLRRDSAEASFRVMGRLQRLYLVAMTPKSMYMDGQGKRTDFRPQSIWKKALKDEGEYALPFGSTQQYWKTFNNCQRPGGGGRFFPAELVLLPMGILGPEALVLGNIKKDARSNITTPPGKYSTNIPGFYKQSRELQHRQATSSSSNLTLLEMLASEGPRTADEAPMEPSPSICQRATTAYEWPSGSMNKPQQTVLSERVNITKRRIPTLFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF23</accession>
    <name>A0A6A6RF23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_499069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF23"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="273" mass="29133" checksum="51AAC992FE92FDBE" modified="2020-06-17" version="1">MSTTKPTLAFFGATGGCASAALTAALKDNYTATALARTPEKLRKILASAPHSVPSSTLDSALTIIAGNVKSVEDVKKTLVSPTSPGHLVDTIVFGVGGAPRFNKSLWAPFTIDDPHVCATGTATVLTALTSLAEEGIRTTASGEKPVYVTISTTGVTDGQRDVPFLLYPLYHWALQVPHEDKRSMELQLFGAAKDSKIRNFVVVRPTLLSGGAYGADKVRAGWEWGIRGVEGREKEQGPALGWYVGKTDVGHWIFQEVIKKGGWEGKCATLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF89</accession>
    <name>A0A6A6RF89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_588691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="320" mass="34903" checksum="4E5C45BC362B865F" modified="2020-06-17" version="1">MPFTRAYSYALQSHDVQLEHFVAFIDALAIAQAAPAPLQALNVVGNGIGLVPHHWAQAASAGIGLAAGAGTAAVTITRTKMFMERVNKEYFGPRALKASLVGDEELAAVVGYPANGPVLLPLDLNSDATTIRERRLQALASHMSPLTFDVPPPAPPSNVLDKLSAKQIQATIAKNQKKAAKDRDKLNRTSSSSSSSSDSSDSGKPTRTDKVERELHALELEIEQIDLKAQKKTLGKGPKKAGKTEEDRCKDIGKVEKKREKLLRKYEGKEPKMSGYKEGALDQAYPTTKPKESKKQREKDEKASKKARKLKWIVVTNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8H6</accession>
    <name>A0A6A6Q8H6_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">UPF0047-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_532364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the UPF0047 family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="220" mass="24088" checksum="0C6C5B3C6128375D" modified="2020-06-17" version="1">MPLSSTNTLLFLLIFVFAFFPGPFIRVLQSPFTSSPKTPAYPTTTCACCACNNPSPATKITTPPTALTTPTPATMSWFQKTITLPSKSRGSYLITSDIVKELPELQNYKVGILNLFIQHTSCALSLNENYDSDVRADMSDALDRIVPEDKGGKERLYRHDAEGSDDMPAHVKSALIGASVSIPISNGKLATGTWQGIWYLEFRASRHSRKVVATIQGEKV</sequence>
</entry>
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    <name>A0A6A6Q8N9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
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    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_520812</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00561">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="34036" checksum="A8EB2D50FC43B18D" modified="2020-06-17" version="1">MATQQTAPTLYLNTNGHRYAYRYFGPASTPNPPVLFLQHFRGTMDHWDPDLINPLAAHRPILLFDNAGVGKSSGIVADSFSGWAAHVVAFLDAFLPTINRTNVDLLGFSMGGMAAQMVALDTPRLVRKLVLAGTGVSWGPDVEAGEVENVMLLASASTDAEEKAAFLKTFYSPSAEKQARGAQWWERMNQRQLDGRSPYLNAEGTQRQLAAVGKWLNPETDPREASYKRLGELKMPVLVANGDNDVLIPSHNSWVLSQRIKTATLMIYPDVGHGFLNEQAAMFGKHLELFLDSEAVNPLSGEQYCENPF</sequence>
</entry>
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    <name>A0A6A6Q8V7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_215375</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        <location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2488878.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_601267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q908"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="504" mass="57143" checksum="58D52F23A0B81FBB" modified="2020-06-17" version="1">MAPLQTLLTDFGLLSSASSRSATSLLALPNELVLEVASYLDTQSLRRLSNVNWRYQNLLEGDLIKRATKDDLERACENFDMKVVRYLFEHNLVGIPSSRGSWRAFEALSIEWSDLCTGSDHLSYSLRTWKNWDAFVEISSLFVAKAIENGWGTLSGPVENRYMGPTGDDFYRGLLRYFLTGTLRSRTRGLDGSKTETPIKQMLACGFNGALVFHQVIVEEQDEVKPIRREAHKIPLIRVLLDAGADPNGPWTQGGWRDERWWNPKATRRPLTMAIRHNYLKIATMLIESGAAVTGHDIWESATTSPLNEAVTKNLEVDFIRKLLQLGADPNFVLDEGGKYRILGYPSWFYIYRSPEQLAAVISLLLEHGADPEKMIPGQEDGGNLMQRRKHFRGQLNIGSLASTMVALEKKLPGLVPGADILLNTTQAVQNMHDVLKMPRTRSNIPELLDTWRCMEGNWKMLKAVSDTFTPKQLPIVVEYHQLWDEHHVEVEQFLDHDWPSLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q936</accession>
    <name>A0A6A6Q936_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_497015</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q936"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2488569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="43332" checksum="743ED1B65F9E0F2B" modified="2020-06-17" version="1" fragment="single">MGFAHGAQLQQEAAMGRAQDGGKGINQRIREVWKANLAQEMKILRALVERYPYISMFPGVVARPMGDFHTKASYHYQTVRCNVDLLKIIQLGITLFSVNGDLPPNQLESSAIESASRPQYANNLIMCPCTWTFNFQFSLENDMYNEESIQILKKSGADFEKHAKDGIDPQEFGSLLLTSGLTLDTDVNWISFHSGYDFAYLVKMLWCQQLPADEDSYRHLVNLFFPNVLDVKFLWRHANKMLNKGVINSQAATILTNLGQKSGLQDLADELGCQRVGTQHSAGSDAWLTGSVFWELRKKVFDGNLPEDMNGQMWGLTGVAPPASAATQAAALAAGGAAYQQGMNGQGMMSFHTGGTPGTHRGDGPSTPTTNPAGLAGTPGPHGGLMTPGGAFGNFTYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q959</accession>
    <name>A0A6A6Q959_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_575976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q959"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="550" mass="60351" checksum="3A0C9B282CAFAE68" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q960</accession>
    <name>A0A6A6Q960_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_441962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q960"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
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            <end position="189"/>
        </location>
    </feature>
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        <location>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2488968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="408" mass="44022" checksum="A384E799A59245F8" modified="2020-06-17" version="1" fragment="single">PPVDRGAGAWKFLLGCWLIEAVLWGFPLAFGIFQSHYSQHSLFSTSKNIPTIGALAVGISYLGVPITSPITLRYPQYHLHILFLGWALCISGLILASFATQTWHLMLTQGAMYGVGWVVCYTPFLIMLNEWFYDRRGLAYGILFGASGVSGLILPFALEALLARYDFRITLRIFAIATVLVCGPSFFLIRPRIPVHLQHKPPPPSGAPRPYNFLRNPLTYVFGFSIALQGLAFPLPPTFLPSYATALALPASSGDLLLSLNSLAQVTGQILLGHFSDNVSTHLPHSISSLITGLAVLLLWGPARGIGSLAAFAALWGAFAGSYSVSWTKIAARMAEGEDEGRRAAATMTLYAWFSFERGVADILAGPISALLLGSEVRVGEFGVGKWKRVVGFCGGVLLMSSVGGLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9X3</accession>
    <name>A0A6A6Q9X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_623117</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9X3"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000040">
        <property type="entry name" value="Probable exopolygalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF6">
        <property type="entry name" value="EXOPOLYGALACTURONASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025557516" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2488839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="440" mass="48480" checksum="B92935C79B5BF8EB" modified="2020-06-17" version="1">MKLLIIVFAFAFLSSAVSIERLIPAGASVVEAPSPSLNKRWAKDKWGNGLESQRRAVTIRASKNDTDDVADDFLWAMRRANKGGLFHLEKGKTYVIGKKLDLSWLNDIYVKLDGEIKFTNNITYWQSDYFYYPFQKSITFWVWGGKNIKLYGSGTLNGNGQAWYDAFAGKQILDPGNTFLRPILFLTDNATNVEVEGIKFLNSPCWNTFLVRTKDITFDHCRFDAVSTNVSSRPANTDGFDSLNVDGLTVTNTEVNVGDDCFSPKPNTTNILVKNLWCNGTHGVSMGSIGQYPGVLDFISNAWLENITLLNGQNGARLKAWAGENVGYGYITNITYKDVHVENTDHPIVLDQCYFNINETACAQYPSNVNISDVRFINVHGTSSGLEGRVVADLTCSPGATCEGIHLEDIDITSPAGGPPVIVCNNISGDIGVECVSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAF5</accession>
    <name>A0A6A6QAF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein-like protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_532008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAF5"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2488966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="567" mass="60843" checksum="C15516E855C6761A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAV8</accession>
    <name>A0A6A6QAV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_622806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAV8"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2489271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="461" mass="51513" checksum="F6C49809CAE397F7" modified="2020-06-17" version="1">MAVLEEVLRGKYPAKTHAKKVVQWMREQGAEVGEGTLYLEGQKTRMIEDNDEPVPFRQRRYFFYLTGCNLPDCYFTYDIKTEKSTLFIPGVDPEEVIWSGLPMSVEEALESYEVDAVLPSSELNPHLASASSSKFTIYAIASQISDDVTFLSYNTKNVELLKPAIEYARVTKTPYEIALIRHANSISTTAHIAVMRAVAHVSNEQELEAIFLKNCVERGAKEQAYHSIVASGTSAATLHYVKNDQPLDNTLNLLLDAGCEWDCYASDITRTFPRSGTFSPESLAIYNIVLSMQKQCTEALKAGVLWDDVHLLAHKIVIGGLLELGILRGSADDILAARTSVAFFPHGLGHYLGMDTHDTGGNPNYADKDPLFRYLRVRGTLPAGSVITVEPGCYFCRFIIEPYLKDEKHSKYIDESVLKRYWSVGGVRIEDNILITESGYENLTPTPKEVKEMGKIIKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB05</accession>
    <name>A0A6A6QB05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_160340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="277" mass="31964" checksum="B1FB5B5708C62B88" modified="2020-06-17" version="1">MPMVPKELDMAVASRKLGRSLVIVQPVRTPGPRGIPRGIPEIDQLDVNKRTALVARYAIGRNQDLYEPMVIGRYMGTWYSISTKDSAAVRQKHHQALNWESQWHRLRGKGFKLNMLGLQMVCIYIRHLVRSKLKISNLDAAILTFGHLPTTEARLHGCQEEGSVMTTRWLNRAMPYVPKQAKRFAINVDRMWEVIGVLLLLENKHEKVAHLMAEGYVQGLLDERDRLMKDCIFDYAIWEIDDTDGQINDIPSVHFETFELEYPETNALQDPLKGWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QB08_9PEZI</name>
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="99" mass="11083" checksum="9C43CF6FBBE397C9" modified="2020-06-17" version="1">MDSKSYELAWNTGQASGTGPSYQPWRAFWPPNPDVEFTEEEKRAKPWLTWRRDPDDVNVKPWYEWVNEFTGEIDTPCTDGCDSCGGKGCGVCSTVAEGG</sequence>
</entry>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="non-terminal residue" evidence="3">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="115" mass="13585" checksum="E23C6931E154DE70" modified="2020-06-17" version="1" fragment="single">RTEEPPRNTEHRIICCRKDCLNLDQTFDRKCERSKHMDKHDRPYKCTIAGCENLRGYTYSGGLLRHEREVHRMHGGSRKSLFCPFADCKRSSGQGFTRKENLAEHIRRVHRSNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QBW5_9PEZI</name>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="405" mass="45072" checksum="95BEEBDED307573A" modified="2020-06-17" version="1">MVEQHTKQSRQTDAYACLAITFFAALLCMALRLAARRVTKVPLWYDDWLGIIAFMFAMVWSGLLIWWLQSGFGLFLIEIDMPVDQVLERSKLILWNAEIFYAFSLAFSKLSILAFYWRMFKNSNIKKPIIVLFVSAIVWLILRTFMAIFHCVPVQAFWKSNVKGTCNINDSKFFFGTVLAHLIIDIAILILPIMQIRKLQLPITKKAAVIAMFMFGFFVCIASIVVLSESLKYDTSSPEMAWNVAPIIIWATAEVNLAIVSACLPMLRPIWLLATRHSLSKGTSSGNNGPYAAQSSDMFTHQASAGGKELGTITINKKSRASDEEGDGDSTYKLASSSHREGSISDNSDYHGYTHDGNLHGPSTVITGQNRSGEDRDAEESWAGIGGMRGIVVTNEIGVRVSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCA1</accession>
    <name>A0A6A6QCA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCA1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="28364" checksum="8C63C8205656DADE" modified="2020-06-17" version="1">MSKEVITPQKKITLEGKIIAITGANRGIGLGIADCCLTNGAARLYSLDLASPSPDSDFTALAKRFPGQLFALTADVTNEASVTAAVDQIIQEAGAIHGMVVNAGRTLHKAALDFTTAEIEGLWNVNLFGSFYCARVAARAFIKLNIKGSIVFTASMASYRPNKRVPSAPYGASKAGIRNMTHTLAMEWAAHNIRVNSVSPGLVNTAMTYWVPQQPDWEKQLEYYGGMPRLAEVEELGGAYVYLLSDAASYTTSIDIPVNGVIGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCH1</accession>
    <name>A0A6A6QCH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_586027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCH1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="167"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="346" mass="35763" checksum="C7E700DA90B298FD" modified="2020-06-17" version="1">MTSTTTETTAQLQYIEKGGAFKIVQVPKPTLAPGEVLIRQRVAALNLVDVKQRDLGLMIPSWPTVLGIEGAGVVEAVGSEVRDLQPGDEVAGLEGGGAHDVAWGGAFQECVAVPATLLAKKPKNISLVEAASLPVGFITAVCGIVYSLKIPLPFLHGLSTKGEAPSSVLVLGGSSVTGAAVIQLLRKAYPALPILATSSPKHNARLYDLGATSVVDYKSPSVVTDIKAASPGAAGVDVIFDCVSAGASQTDISDVFDSAGSKRYAAVVTSVTVPVPEGVTKLDVGGWNIVDLQGGMQLISSLTKLVEEGTYRVPLPVRVVGHGLEELPKVLDEVKTVSGEKVVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDN4</accession>
    <name>A0A6A6QDN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_586218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDN4"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="627" mass="69681" checksum="B98F8A3361371906" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDR2</accession>
    <name>A0A6A6QDR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_543629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDR2"/>
    <dbReference type="OrthoDB" id="3788364at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pan_app"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025640280" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="621" mass="64585" checksum="5D37B83E107F4203" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE37</accession>
    <name>A0A6A6QE37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE37"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="357" mass="39125" checksum="14350AA5D27A044B" modified="2020-06-17" version="1">MAPQITTAEDLESYITALTATGIPTEPYKSIDLLTGGTANYVWRLTMHSGGTVIVKHAEPFVASNPSMAFPVNRMDFEARALHSLPPLLLAAGAPARVQPVPLIEYVAADHMLWIADGGPRHLKDAYSDPALDVPALGRDIGTWLATLHLATASTDIGDNRTGKFIYRHAYRNLHTAFEKFGFDTALAEKVDAEFGALLASDDEVVCHGDFWPGNVLVADDGGLTIADWEMVRRGCGATDVGQFAAEAFLLDRFRGWRGLRGAFLGAFMRARGGKVDKGLLRRVAVHWGVHIAYWPTRVEWGNKEETRELVAIGVKVLTQVLEEDWEGLVKGELFDGLEGVSDLFRRSKVDVEVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE45</accession>
    <name>A0A6A6QE45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE45"/>
    <dbReference type="OrthoDB" id="3880115at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="239" mass="27596" checksum="D281B84777E77861" modified="2020-06-17" version="1">MEIDVAATDPKLPSKPFPFFALPAELRNEIYAHHAATENTVTVAMRRSRVSEDWHAGYKPLLPKPPALLQVCQQARTEYFPIWVSQTEFTLGLASDSSIEVVKMWLEWIRPFAGYLNQMSFILRGEKWTEGRSDLPPHGWIEMVYDGWVEYWFDFRKGVADGDLIYVDGERLEYSAPADRSEMIGKEREAFGVTVEEMRKKRQAGKLVVGDVKKLINALVRDHGHLVETRVLRRRFGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEF8</accession>
    <name>A0A6A6QEF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_575180</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEF8"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="117"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2490424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="433" mass="45764" checksum="30F794BAE7ECFC50" modified="2020-06-17" version="1">MSSDKLLVLLVGNGGREHAIAWKLSQSPLVAHIYAVPGNGGTAALPNVTNVAGIGQEDFAALTQFAAEHSIGLLVPGPEAPLVAGIADYFKQHAPGVKCFGPSLGAARMEGSKTFSKDFMQRHRIPTAAYQNFGDYEEARRYLDGVGHDVVIKASGLAAGKGVVIPATKEEAQKALTEIMQDKEFGAAGDEVVIEEFLEGDELSILSFSDGRTVRSLPPAQDHKRIGDGDMGPNTGGMGTYAPTRIAPQSVIDEVHKTILQPTIDGMRQEGIPFVGVLFTGLMMTKSGPKTLEYNVRFGDPETQSLLSLMKTDLASIMLACVDGTLSTKELEVLPKSAVTVVVASGGYPGSYSKGTLMKLDPVPEDVVLFHAGTTLVDGSLKTSGGRVIASTAIAETLEEAISKAYSGVQSIHFEGMQYRKDIAGRALKKTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEX7</accession>
    <name>A0A6A6QEX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">BU16DRAFT_621432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEX7"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="226" mass="25096" checksum="2352535AF44C1AF0" modified="2020-06-17" version="1">MEDEPSDLIGFGEDLVQLPEYKAAGVSTVDFDRLLSTPLKLKEDLSNGCGGQLWPAGMVLAKYMLLVHKNNLKGKTIVELGAGGGLVGLAVAIGSQIDQPLLITDQKPMFALMEQNIVLNGLEAKAKAAIYDWGEPAPSEVPSHPDIILAADCVYFEPAFPLLQKTLEDLIGEETVCYFCFKKRRRADLHFMKAIRKKFDVKEVNDDSDKASYRRENIFLYTITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFF6</accession>
    <name>A0A6A6QFF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHL4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_133150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFF6"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <source>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="352" mass="40040" checksum="702DF9F946A51835" modified="2020-06-17" version="1">MPITTELELRRFLSSKDIPCHEIEDLAGGSANFCWRIKTELGKHSIAKHAEPYVRIMPDVPLAIERMDYEHLALTAIPDIMSTNEHVRLPQLYNYFPDEHVMCMSDGGSQDLKESYKNDDNIDIPLLGRRIGSWLAKLHRETSEPDTLDFVKRTFDNETAKSIFRYTYNGLASVLKQHGHDPALGERINTKFGTETASDKTCLCHGDFWLPNIQLENQDDAVKVEKEDEIKLWAPVLTIIDWETVRVGNGATDVGRFAADSWMVDRFHGGKGMFEAFLKAYLTEHPLEQRDKIRLVVHFAVHIIFYSRMRWTDEEGTAELVQLGKAMLDAVEADDSKSLLTGPLGPLFCKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
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        <name evidence="9" type="ORF">BU16DRAFT_119349</name>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 269.34</strain>
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        <subcellularLocation>
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            <location evidence="1">P-body</location>
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        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
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    </dbReference>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Mondo S."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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        <source>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    </reference>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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    <sequence length="317" mass="34831" checksum="233D986D131A5069" modified="2020-06-17" version="1">MEPARDAPWAEHEKLYLLAEIIKAAPIPSSVLYGIIRDAQIQPKWSDIALPHGRSLRSCQQAFDNLAPSYPGADYRQRPPLPAPVVGSYPGPEVPKKRPLQPETSTPIGRLLQPRPPHSYPGEYTSGPTYVMSPVTEPANKKKRGRPTKAEAQARADAAAARGEVYPPPRKQRTSLPSVEPSPLPSGRMTPGPAPMASMVTTPQVPHMEVEESSSGKRKRQKPSPLELERGPRGEAVIDTESPSLIGSASAEGLRPPLFSQQYTPASAAPYSATDPRDRDRDRERDRDRDVRMEGVEDPQQQHRTTTPRSFKDTVGI</sequence>
</entry>
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    <name>A0A6A6QI07_9PEZI</name>
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        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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        <name evidence="7" type="ORF">BU16DRAFT_529438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI22"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025556925" evidence="6">
        <location>
            <begin position="18"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="60299" checksum="FA64E106BD93914C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIN9</accession>
    <name>A0A6A6QIN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_564395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIN9"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="18912" checksum="17287E15C9D8CBA9" modified="2020-06-17" version="1">MIIYKCLISGDEILSDSYDIKEVDGVVYEADCKKITVGGDNIDIGANPSAEEGGDDTEDTSQQVIDIVHSFRLNETQFDKKSYLSHLKTYMKQVKEAMKTRGASDEEVKEFEKGASGFAKKIVGNFKDYEFLIGESMDPDGMVILLNYREDGVTPYVTVWKHGVSEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ29</accession>
    <name>A0A6A6QJ29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_593677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ29"/>
    <dbReference type="OrthoDB" id="3920378at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2492241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="316" mass="35494" checksum="235494A39CEFE05D" modified="2020-06-17" version="1">MSQPPRFSGSRRGQLPTPPSPYVVIKTLKQPGDGDGGACNAGIFLVRTIRHGKLRVEKRVTRQDMETRHMEREMKALKQLRGHFNICHIFGYLPRQRHPALYLEFYDLGALDTLIARYWRRSETLPHGFVGHTLLELSKALCFCVHGYVFGSGGMVPENWNAIIHRDIKPGNVFLASPSDPRALYPRIVLGDFGCSVSDIDIVNGTASALTSRQAPEFSPPEAPAYSRRSDVFQLGLTIHCMIQNLDVPDHDSISRTWEMGNPYSDPLDGILLQMLLPDPSSRPSTLHLPGIVDQHFQAFCARNAPRPLKSWAFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK47</accession>
    <name>A0A6A6QK47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_114902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK47"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="206" mass="22296" checksum="3BBB020ACB6DED10" modified="2020-06-17" version="1">MPHLALRGPAWISPVPTSTPPPIVLTIERSTTTYITTIYRTKESDSVASTGYIEPRISDQSPGVIAGAAIGSLLGLVAIFVVCCLCCCQGGRSQSKLARRKSLPTNKQGLRRELLSLERNRIERNDRLVIVEEGPYNGEEARLDTEERAQSGLEVSLTVTDSQEGSSFSDRTDQAIGSPPRAAGSAGRGSPFEVPTRVAWHLSFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKS1</accession>
    <name>A0A6A6QKS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_592473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKS1"/>
    <dbReference type="OrthoDB" id="72726at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="237" mass="27345" checksum="011CC683E7472F20" modified="2020-06-17" version="1">MTMCPLLALPREIRDMIWGLALQEAQLELPPLEGKAQDYDKALPITTTGKAFGDGLPALCRTSKQLFEESTPFFLSRIMVTCTSASEIEELLHFLEKIPNNEGFKAIHQLRLGGKDMFCRWQHRQGENKDFAALKRFPKLEDVLFDVRQCGHEELFLREGVWYCRYESDQPRLIEPTFEKLDLNGLFECTSLKAVIIVKTHHVGLVIHWDDFHDRMAPWIHKQFADKGLEVSVMKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKZ6</accession>
    <name>A0A6A6QKZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_574053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKZ6"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025704340" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="316"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2493005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="466" mass="51855" checksum="CB23BEF65887EC8C" modified="2020-06-17" version="1">MRWLFSFLVLALLGAVQALSSSGSRLLVVLEELAEKDKYSEFWDDLRGRSYTLSFESPKNDKLSIFKHGERAYDHLILFPPKTKGLGPSLTPKLLLEFLKKDGNVLLTLSADHPTPSAIVSLLLELDIHLPTDRNALVIDHFNYDTVSAGEKHDVLLVPAPKALRADVKNYFEVDGTIAVPRAVGQGLGNTTPHLAPILRAGSSAYSYNPKDEAEIVEDPFAVGEQLSLVSAMQARNSARFTVVGSVEMLQNEWFDAKIGAVGSKEQTTTANRAFAAKVSEWTFKETGVLKVGRLQHYLNEGKKNVNESAVGVPEHNPGIYRIKTDVSYTIEISEYTSTHLSPFVPPTADDVQLEFSMLSPFHRLSLTPLAQTANSTIFGTSFVLPDQHGIFNFRVNYKRPFLTSVDEKRQVTVRHFAHDEWPRSWNISAAWVWIGGIWVTVAGWIAFVALWLYSEGVEKGVKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL07</accession>
    <name>A0A6A6QL07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_529707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL07"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="134" mass="15506" checksum="2278C05B103AF7BC" modified="2020-06-17" version="1">MQRRMLSKEDEAATEDIEVRREDQEKINKFSTLHQKETGIEEELKGKQKEKEDLEEISTELELVDEDEKVPYKIGDCFVSLPQSEVLELLTASTEDIDQDVTKLEEKLGAVREQMSELKVALYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLF5</accession>
    <name>A0A6A6QLF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_93964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLF5"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="283" mass="30941" checksum="D51A80126E0AD635" modified="2020-06-17" version="1">MPSAQPVTVGVLALQGAFSEHVQLLRHAAVALKAHDSETRFDFLEIRTPQELVRCDALIIPGGESTTISLVAARSGMLEPLRDFVKVIRKPTWGTCAGLILLAESANRTKKGGQELIGGLDVRVNRNHFGRQVESFQANLDLPFLRDSVAVSGSEATRPFRSVFIRAPVVEKILPHVDGIQAGEAEREETVVAPSKQPLDKLAKKELRAEVEVLARLPGDATAIKDEEKTARAAGEEGDIIAVRQGNVFGTSFHPELTGDSRIHVWWLEQVLNALDRRKQIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLQ5</accession>
    <name>A0A6A6QLQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_75700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLQ5"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31043" checksum="AD26E051B9A7C6E4" modified="2020-06-17" version="1">MSDFLGLPSELRNNIYKRLLVRDEPVNPRTRMNLHMRRHNLTPDLLLVNKTIYREASSLLYAQNCFDLRGCGPNSQAEHAGLFFAKIGSTNTQHIRHVWIDFPHFQSLDADTITLTHAADCMLASIQSNCINLRTLTAIIHYNIAHCMDFELIESDRPNIVPKALALADARFRGIASLREVFVKVYKKGPSRRLESELKGFGWKVNGRVWEEDGSSSEEPSDNGEGDEDSSSDEEEDSGEDDEDGFESDDDADDGGDGADLIGTDGLIYGHPLNDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMF0</accession>
    <name>A0A6A6QMF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_619630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMF0"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="39437" checksum="F7CED85701D409AF" modified="2020-06-17" version="1">METIDREVYFKDDVSVTSNARPIGIFSSYMLLCVSLTILILRSLYKSSQRLSSPQKATPDQFGRTQRVVLFAALATISLGTTWYYMFSFFSHSYRHWLSIQPIPLLQDAELELGAWLKDTKLFKEAWGTALETPERFWWTQQIFFFTSIWSVFQGQQGFSRRIPHLWAYMLLGQVVAISFATNLFFVAVSLNPVSTGGGSPRNRERWTPPLSVLLIPLLATFVSTGLIPSSVSKPYFMYILLLPHFALFVPPILYNIVPPSWGTTHTTLKAVGQYYERVYSLLVMLSIVFVALASRPAWGGISAALYEHPAVSSVGWDVILCWTSWGVWTLVYQIGASGVKGKTEVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMJ6</accession>
    <name>A0A6A6QMJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_528868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMJ6"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="419" mass="48264" checksum="D38B33EDA2CE52E5" modified="2020-06-17" version="1">MDYDYYEDMAKRRKAFRAKWPDESPSPPPAEVPRAVQPMQPNRTQPYEIVDLGMSSPESIPQSPPPNPLKRPRANNTDVTMTESPTDEARQPPEWYNKLRIEAPLVKASRKDTRNGPTLAKISGIKGACKTCEEAPMGDLTEQFVTLRNLIHDMEFLTVDQYLIRATRMLENRIGLPRIFDLNFTKGVNYPWDIKLDAEQLHTRWCRGVFSIDILHGIKRAYNRNRDGQRNADKIDPEYKKRLYANHYGQGNLINGQWWPTQLCTLRDGAHGSAQGGIFGEKNRGTYSIVVSGGHKYGDKDEGEEIWYTGTDGTDETPTENTKRLFESCEMPENEKEPVRVIRSWNLNKENKYRPAGGFRYDGLYDVVESEPVNKNLGMYKFLLVRRAGQDPIRFEGVEMRPTQQELNAYKKLQQDDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN07</accession>
    <name>A0A6A6QN07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC drug exporter AbcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_489512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1250"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1320"/>
        </location>
    </feature>
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        <location>
            <begin position="1340"/>
            <end position="1362"/>
        </location>
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        <location>
            <begin position="1374"/>
            <end position="1398"/>
        </location>
    </feature>
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        <location>
            <begin position="1490"/>
            <end position="1510"/>
        </location>
    </feature>
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            <begin position="178"/>
            <end position="433"/>
        </location>
    </feature>
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        <location>
            <begin position="870"/>
            <end position="1112"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1563" mass="174855" checksum="F03CD1EC42C99B66" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNF3</accession>
    <name>A0A6A6QNF3_9PEZI</name>
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        <submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 269.34</strain>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </source>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="597" mass="64765" checksum="1E6C3FD108E9BBCE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="KAF2493794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPE0</accession>
    <name>A0A6A6QPE0_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BU16DRAFT_541575</name>
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    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="409395at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001366">
        <property type="entry name" value="ATP binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="6">
        <location>
            <begin position="164"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="346"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="735"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138052" checksum="FC8A9F5A51D02616" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPE9</accession>
    <name>A0A6A6QPE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_562969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPE9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="51323" checksum="12AF6580536B1536" modified="2020-06-17" version="1">MSVETLTTISPITNKPVLTRNGLTEGDLQALPATAAKAFETYRKTSLSERQKIVKKALKLLNDKQDELAKEITEQMGRPIAYTAKEVTTAVARGEYLLKISDDALGDTDGEAEKGFKRYIRKVPIGPVLILFPWNYPYLTLINSIVPALLAGNSVILKPSPQTPTTAEHIQEIFTKAGLPEGVMQHFHCGSLSQIETLVRSPQVQLVCFTGSVAGGLAVQTAASDRVAVRVGLELGGKDPAYIRSDVDIPWAAEEIVDGAIFNSGQSCCSVERVYVDEKIYDEFVSAVQEVLKGYKLGDPFDTKTHVGPVVSKRSAETIRSHIKDALEKGAKDATPENESFKSPPSDGNYVVPTLLTNVNHDMLVMTEETFGPVIPVMKVKDDKEAVKLMNDSQFGLTASIWTKDVAKGHELVEDVEAGTVFVNRCDFPSPDLAWIGWKDSGKGQTLSRFGFDQFVKLKSYHIKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPL6</accession>
    <name>A0A6A6QPL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_563269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPL6"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="2">
        <location>
            <begin position="325"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="459" mass="50159" checksum="A85E19315ACFBF07" modified="2020-06-17" version="1">MDYSKPISVRNNITLGLAMYRPANPKGVIFFCPGGTDAGAAAAWRVALNQTGDYFPNFSGLEDYDLMMMDIRGTWSSNILNVSLDTFSSILLPNPTNQSDFDAIKAASKAIIQSFNESSSPPGFVQFTGTNEVIQDYESIRKALGYKKINFVGLSYGSFRAQLYAAKYPHRVGHFVLDALVAPGYSVFDQANTQILAGNRALLRADAYCQNDPSCPLKAQGRGSVPKVYDELLSAVKNSSLDTFALQFDFYNLLQDQPVFPIISQDLAQLAQGNTSSLAGGGSLTMNDVVAIPYLCSDYYIEDNTWAGFQKSLEAGSKLDTYNVGQTAAWNIRMYCAAWPYAVAPLKPLHLKAPMLFVTADFDASTPTEWATVAWKEADHSALLVRHGDDHTTFNLPASLATRIEKEFLRTGVLPRVQNGTEVTVYHPGMCRAPIPDPYDVPIGFVAGDCATEEGCNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ43</accession>
    <name>A0A6A6QQ43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_43631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ43"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="282" mass="31333" checksum="6016A4807347F6F1" modified="2020-06-17" version="1">MSTRTTEENKMDYLSAIPVELLLMVYEELLVTDGFVPVDTPTPANMLAIMQTSSWHLQAAETFYSKNEFLFTCNAAQPLGPIASGNLHFLRKIAISLCTDHPDLPTTLDRAQLIKAPAVANLKLDQVSVEVCSKLHPLIVDHFDDSLLTQMHPFTYALCFLIRSRVVKHLRIRLNAARFATNTVAVLQKVFRENHQAKATLTFYVGSSYASGNIVTDTTKCERAVTGTYHNSPVSVGDFVEEDLTFDNIDDMSMDDASDMEDEEGLDAAVMGMVTFAPELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ86</accession>
    <name>A0A6A6QQ86_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2494648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="167"/>
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            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
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            <begin position="283"/>
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            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
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            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
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            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="469" mass="51874" checksum="B9EF1B283F16472F" modified="2020-06-17" version="1">MVSTWTTKKLKGEVTDQTDAMVDEMVDEMKRNWGVENIATTIPQQFRYIARVPRSNHRRYERPRRAEDDPTRWSYGVLRKLRKLTRCSKGDVAGGLASLQLMVEKMETARDRTGLLGLWPRNLKPAITHYKHFHPGAVNNWARVRSEDLRQVEAILGETLGPSACVMVALGPAPTGPTAPIEDSDSESEDEDDENDDEDDDEDDDDDRPDGAHTTTTTLPIRGNTHATDLGEQHAENGTATTGTLMGSGTIAQDPLTDPNTPSDAADLAARNAREESSLFIPEATPEPANMDQPHTTEPLTAKDTADPTCIRAQREALLATIQNQNGGSLFGDGPGTSTNTALNMQPTTTESQTLHDHANPLSQATGDSAPPPESDIDIKPEPADEVDVKIEPGIKIEPGLTSSFRRKRPGYYEFFEDDPEDKELLRLRIDVEEKEARAARTRFEAMARERKRQRKGRPGGWLNPLVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQC6</accession>
    <name>A0A6A6QQC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10445825at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="398" mass="45474" checksum="B2C6074474B0A457" modified="2020-06-17" version="1">MASRNSGGGSAAPQPASMTELREPLRNAQAQAGIAETLNAELRQRVEALESDLNLARYRATLAEERYKAHIRRDVERFHRHAARLSNRRKRNMTAVKEELEKRVKKVEEERDLAKKAAGDTEELRKRVEKVEMERNLAMKTVEDMAEKAANDSEDLRKRVEKAEMERDLAMKTGKDLAETSAHEMEDLKKRGEKAERERDDALKMVKDLEDAQNKLQAQPNQVLESAGNALVKNPEEQPQDVVELKAKLEGLRVTLKRVRKERDTAQSVSRIKGREHAKLKQAWDQERIALNKSGDTLTAKIVTIEMERDLARESTENPGESRGDMELRWETQHHIAIARSKRVSEAQTLEQNIADTCKTLLGPGVLQGSNLARYRRRNVDICCDTIRSFLVNYRLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR61</accession>
    <name>A0A6A6QR61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR61"/>
    <dbReference type="OrthoDB" id="10494653at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="215" mass="23867" checksum="B538D68D2D2934D5" modified="2020-06-17" version="1">MPVTPSTPEQRAGHLKPAIASTPKTTTNQPTPSHRVEILGDIRRNWSLCHQDQILPSHLTPTGPTSTWRDPVLSQDDIAHIALLYRLDHGAGSTPSEPIPVLKYTLHEQGVCVRNPTKRAPPAGWASAVLDVTAEGVLVERLERGEERRELGAEEWSGGFVRAVGKLSELTKGRKEEAWRFLDQAQAERGGREVTTRDVRRAGQIVGERDEEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRD2</accession>
    <name>A0A6A6QRD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3688221at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="353" mass="39846" checksum="90291932892666FB" modified="2020-06-17" version="1">MDVVAFTRRPETQPILERPAITTRCSVIRRYSYPVILLSKRREVSMESSTVPLDRRNSISPDFFEPSPPQSRRPSLWIGGDEEAERRRDQLRALDIARLKHQSIASTNDAAPAESDSQRSSVQLKPYTEPTIQALQRVATSDNSEETNIYSHLIRRVSRARNEVAPQPTAKRMTSELARRRLSSQTIPEGRSLSPIQTLSPAELTIPGTFFPGNTDSTFQSPSRRHFSISMSPSSSRSPGSIHSTPSDVTSFSATIPPPSPLQFVWPLQPPSARSPTRSRSENPFSSSITTSLLREERDRVYDRHSLDSRSLSVLLCQSCFSRDSTFNRMIDGLCEVCGEDKVLDQHYWERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QRP5_9PEZI</name>
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        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRP5"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45937" checksum="AE6A2BE61549862F" modified="2020-06-17" version="1">MMQRSNFTIPEEFASQVRFVDALDKRSDEEILDSLTKHTPITSEKNVWTYWHSGLRSMPTWCQRNIVNWVRLLGPSWTVRVLDTVPDSPNHALTWLDADMLPEAFVKGTMAGPYTGPHSADFQRGAALYTHGGVWMDVGIVLIRHLDKICWDQLEDPNSPFEVSVPWMYGQVMANHFVASRKGDPFIKHWHDLFVHFWKGQNDHSGIVQSPLIGFVKDVKFEDSVARGFKWDFKVDELTVMGYIGQCVAWLRLCMLEEPNGGFNGVEYWANKILLFDSLTESWAAEQQVGFTGQALFDMLVTKRDADPESKEYQTAYKAIWRLLTKSSLQKITHGKHLTQTPALGIFLDAKENKDVDIAPGTFAELLRFGSVYLEQTRESIDYVKAERPTPDHIIKKGLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS89</accession>
    <name>A0A6A6QS89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_385217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS89"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="657" mass="72688" checksum="18D31368A95052A4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSC7</accession>
    <name>A0A6A6QSC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_461831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSC7"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="252"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2495066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="694" mass="77343" checksum="ED766C69655BA944" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT38</accession>
    <name>A0A6A6QT38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_460954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT38"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2495336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="730" mass="80446" checksum="95ECF8EF64440C4D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT86</accession>
    <name>A0A6A6QT86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_527204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT86"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="694"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118114" checksum="04274421C295D8DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU36</accession>
    <name>A0A6A6QU36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YggU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_561969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="118" mass="12654" checksum="091851C73BFCD1B5" modified="2020-06-17" version="1">MLPAIRLIASKPPSRTYTLHLICHVKPGVASKREGVSAVTASGIELCVAAQAREGQSNRAVRELIAEVLHVPKSDVEIAKGMKSREKTIVVSNIAIAKSGIEETIESIRNKIEQSVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU37</accession>
    <name>A0A6A6QU37_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="86"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="934" mass="106937" checksum="AFCF16A6A9779C8D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUB1</accession>
    <name>A0A6A6QUB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-N-arab-like proteininofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_527478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2495704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="367" mass="41360" checksum="0FFF673A667FD182" modified="2020-06-17" version="1">MVATSLYILVALVLGLASSQVNAANTTGSFTNPILDTGADPWVIRHDDYYYMTYTTNDNITLLRSRGLTDWKNADAKLLFKPPVGMNYSTDLWAPEIHQIDGSWYVIFTADPNGDSPPPEVDMYCDMNCPAVFHRMYVLEGPGSDLWAADFTLKSQLNTYDQFAIDGTYFQHSTGLYHIYSCWYRQYDAWPSNLCITKMTDPWTVSSNFSERQIISVPSNPWEKTPYGRPFNDRLASNEGPEQLTNPKTGQTFVIYSAARSDNRNYCLGQLELVGDDPMNVQDWKKHSDGCVFYQNALEGAYGVGHASFTTSSDGSEDWIVYHGMRDPTNGWSARTIRAQKFTWNTDGSPRFPRPGYGPYALPSGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUK5</accession>
    <name>A0A6A6QUK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_459825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUK5"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025570213" description="Glycosyl transferase CAP10 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="146"/>
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            <begin position="35"/>
            <end position="45"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="452" mass="52242" checksum="9763A40D51CE24A7" modified="2020-06-17" version="1">MFLFLVISITVLPLKTFDVLHFGTSSRNGSHKTDPTWNHPSSSHSWTFQAPRDAKNYGLSPEQCDASFPDLGHSLERSIAHRKEVGNIKPEDLGVGWRSDGIVRAMIFDNQLYIIEAKGCHRRDFRERTVAVLQSIWRAVVSWPGPIPNIEFTFTIDDGAYDQGVSSENPPVTWSLTRKDDPLFDNLWLMADFGFYVWGATGDYNALRRAIADDEILFDKKDPRAVWRGGKLPEKAPQELRNSLIASSHNQPWADVDFFDWSQGRDGPNNWISISQLCKYLFPVHTEGRTYSGRLKYILNCHSVAVVHKLQWEENFHHLLVADGPDQNYIQVERDFSDLKQKMEHYLAHPAETRRIADNSVKVFRDRYLTPAAQACYWRKLFAAYREVSFEPAFYMTVAEQERLELDRAGDNEEARNATTRKFEGKDRAEKVPRGMPYEKFTLIEIYEDNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV06</accession>
    <name>A0A6A6QV06_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_581402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="217"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="228" mass="26324" checksum="BB4CA89AEB1A33A9" modified="2020-06-17" version="1">MASPQDDDDSLDALNSLEKEAKEFDKDAEIARILSAFKLDAYAILDLQPGVPESDIKACYRKKSLLIHPDKTSNPSAPDAFDLLKKAQLELMDDKHRARLDEAIADARMLLMREHKWTADSPETRTKEFAVDWREKTKEVLIDNELRRRKQLKAQLQEEGRAQRKEEEEVEARKRKREHDQAWEQSREQRIGSWRDFKGGKGEAKKGTGDGEGERPKMKKKKKIKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVH0</accession>
    <name>A0A6A6QVH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_538734</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
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            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="39906" checksum="9202EC05EDB7582F" modified="2020-06-17" version="1">MENWHSTALSWAILSAFGFGYYLYYRSKKQQPATGRDRGRPTQRAINVPRDDNKNNTPGEGTPKATKKAAKPKPARKAKKAAQETGEKVAATMSANSSTTGGEGDDDLSPAVSPKPKPSATKVSGRDVSDMLEPKAVPASVLRLTEPAQPVREKQSHQPRVATPLESKKQRQNKKKVEEKKLQREQEEKERKALEEKQRRTAREARGEPAKNGLQQAKAPTSNAWNLTNGASNTPVRSVVPESQPLLDTFDPVDQDRRSTTSSSEGAVAGSSATTDDVANNDRWMSEEEQMRLAMADSQWTTVPKGRKAKKPKDTSVEGSENGILPVEQPAFKPAPAPPASKPHVEYTTSAPPGAVYHPLDSDWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVP3</accession>
    <name>A0A6A6QVP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metallothionein-I gene transcription activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_526747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7402" checksum="B0B372F021FB7158" modified="2020-06-17" version="1">MSGYVPPTSTAAATTTTSTGEGRSVDYTCGDCNAAVSLKRGEPIRCRSCGHRVLYKQRTNRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW03</accession>
    <name>A0A6A6QW03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_509404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW03"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="286" mass="31837" checksum="3F34EC848A6AFC1E" modified="2020-06-17" version="1">MSMSTSDIELSRRKSYYLNGYPSLAHFIASDRDKSTVVFRRFDRLSARNLLCLQSELAELEAKQDAADQADALGDIATKQNARNWEQVRQRAKDGGREIERVQLAIEIREKLKEYREALMFESTLLSLAPPSQRVLQALRIKFQNITPDDPEGWPTLGGASSNIYDDGNDLVALRTAPHQDRMTTFVRDRLGIFFTARCRSDPIIQDRPADGLTAYVSETKVTIFVTILSTIMSAILLVGAIVSLYIVTSQKARLGMIGGFTVLFAVTLVLLTNARRAEVFGASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWX0</accession>
    <name>A0A6A6QWX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_391574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWX0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="275" mass="31740" checksum="2C1C0BEEFE0214EC" modified="2020-06-17" version="1">MPSIPPRCREIAAKIYTWGFHTEPPPFELIPLYTHWSTEFKRRRSRLLIAATAAAASVPLLHIHQGNSRKGYEDAYDEGFRTIYCVFALVVRHALRIREGELCKRLFYEYLAQAFLLGVTTMMAIHVILSADWLGIVEDCAVVAYLLLVVVLVAQAFLSLLRPGGIRHALLLRPDLMLNAHYFYGLYFIFYAMDVSWSSLFLGLGFHHVTLAALLAYQTWWKMHFLRRDWNQASMETNVELGEQEEKDPPNDWDARVSKWSIDWAFVREGALKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWY9</accession>
    <name>A0A6A6QWY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromodomain helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_526699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
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                <person name="Bloem J."/>
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    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R246"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000126">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="287"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2498576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="440" mass="50759" checksum="AE7B83B8663E54C8" modified="2020-06-17" version="1">MSNQSILRITRELSEIQKGPDLSLAVACRDIDVRHVRALIIGPPDTPYEFGFFEFAVKFGREYPTKPPAVTAVTTNSGRTRFNPNIYAGGKVCLSILGTWRGERGEEWSSAQGLESILISIQSLMSSNPYENEPGFEDGKSEFDKKNQVDYVAKIRHETLRVSIIERLEDYLGIGREKVPGVLPYNADDDYRENLLDAPFEPFKDLCKRRFLWYYDSYLSAIEIEKEKHADGKRFDRMPFEGAGNIMEGCFQYTSLKKRLETVYQKLNEEMDAWGAEGQVATQKELSISSNLQRQYEQIVEFYKNNDSVTLDLELVDKNPFVWQLVLFGRPMTNLDGGMFRIKLYLSTKFPDTLPRIKFETPIFHHRVSKDGILCYNPTRKDDLKSHIEAIIEAVEEESPAYDPRTLVNPEAAKLFWGTPDEKKLYNRKLRRSVQESTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R379</accession>
    <name>A0A6A6R379_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_326887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R379"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="220" mass="25118" checksum="145279301AC7FECE" modified="2020-06-17" version="1">MKPILSSLAASARAAGAGAPRSHLASRRSTKQPHERKFDQEETTIELPKWREEKPTYPGHGVVPNPSLWPRHIIYHRSPQFRSDLRFVRSVCHAVSASRCGGRAGAREGLFSWLNPASGMLRVRCKWGPKLLRSLHVWGYWAFEKFERRRNELGIISISSARGPSHPAIAKAEPTPLIRATRHKKHRRPPCLIHQIEHRVQRQLTPFLCLTYVTNQHSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3H4</accession>
    <name>A0A6A6R3H4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_455200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3H4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6J7"/>
    <dbReference type="OrthoDB" id="5309803at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="125" mass="13953" checksum="59ED32DFE313292C" modified="2020-06-17" version="1">MALFSILPDNLSAFETWTTRIFLFLAILTIGPWAALLIYDVFLYIWRALAYEIPVVGGRARGKARPRAPSLVARPNGHRRSFSIGRPSSRGNNSPASFSGTNRPDLSDVKLRQLHEEYEDSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6S3</accession>
    <name>A0A6A6R6S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_578081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6S3"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34642" checksum="51AADE9B15027596" modified="2020-06-17" version="1">MDQSSAMAEHIMEASGLTLHFSPAQIFLGLAMLTIILLSNGKSLLFMWHVRLVLQLSRHLLFRRRSLTISSASHGAESLFLPVLTSSYTPLLDVDYNLHKSNSTFFNDLDDNRTELMLALFKNVMAPQKQGKSTLKPKTINLGGTACIFKKPIAPFARYEISSRVLCWDQKWIYVVSHFTKPGANKPTAFVLGSQTPSSQMARVVGKADEASEEGVYASAIAKYVFKAGRVTVAPEEVIAECGLFPEKTFTQQGGRAERGGLKPREVSQGHWSWERVQEECRRNLPLAQNFANLDQLHGTRFGGSGPALYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R740</accession>
    <name>A0A6A6R740_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_556831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R740"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="196" mass="21607" checksum="FAE94AEBB275E53A" modified="2020-06-17" version="1">MAGHVHGGKGVEGWLVCAAAGATHWHTSGTGGRHQGRRHCTVPERRPKIRLDSAVAGGVRVIWLAAGHKLVVPDGGGQLSSLPQRLVALSRLRTDLLQRIPPLPPSSQPLLLHFLLAHHRIQRPAVLGRPRPLPASRRPGLQHRRPLDVVAGSPLRRTARQTLLRPVIVPDLREARTSRQLGVLHVSRHRRRAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R817</accession>
    <name>A0A6A6R817_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_285790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R817"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="28093" checksum="E8FC85C96981CA17" modified="2020-06-17" version="1">MGNSCSCAKVTDGADGVCSYHWSSSCTCDRLPSTLFRVSKAMNKLATRTYYLQNQFFVRSSPTTGIASVYNAITRLPRHKLRYIRYLRLDVRESRFEREFQAIGTWTALFTHLTRYGHPNPDIQIVMTGGDWGIYDSEHNNRTIATRTNKIVKILHRLGPYSIVFNTRVFAHCMNGRLLTNSNQWYISRPGRHQNQSCPENRVYRCWTSPLSSPGSHHHEVVLVWSMRTGALLPDPQPLTDFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8D7</accession>
    <name>A0A6A6R8D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_502639</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8D7"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
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        <property type="entry name" value="Cyt_B5_heme-BS"/>
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        <property type="entry name" value="FMN-dep_DH"/>
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        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
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    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
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    </dbReference>
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        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="113"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2500662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="504" mass="56246" checksum="7B6E17122F5C4829" modified="2020-06-17" version="1">MNHKSNDTQAVKLTGADIAKHDSRDSCWVIIHGRAYDVTEFLPEHPGGPKIILKYAGKDATEEFEPIHPPDTLDKYLDKSKHLGEVDMGTVEKEEKEEDPDEKARQERMAVMPILEQCYNLMDFEAVARKVMKKTAWAYYSSGADDEITMRENHSAYHKIWFRPNILVDVEKIDFSTKMLGTKVDIPFYVTATALGKLGHHEGEVILTRGAKKHNVIQMIPTLASCSFDEIMDAAEPGQVQWLQLYVNKDRDITKRIVEHAEKRGCKGLFITVDAPQLGRREKDMRSKFDDVGSNVQNTSGDNVDRSQGAARAISSFIDPSLSWKDIPWFLSITKMPIILKGVQRVEDVLRAVEAGVHGVVLSNHGGRQLDFARSGIEVLAEVMPALRERGWEKKIEVFVDGGVRRATDIIKALCLGATGVGIGRPFLYAMSAYGLPGVDRAMQLLKDEMEMNMRLIGASTIEELNPTMVDTRGLSMHSATVPSDTLGLNVYDPLIGPKEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8R4</accession>
    <name>A0A6A6R8R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_452706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8R4"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="519" mass="55946" checksum="A8BD05717C8ED416" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9E5</accession>
    <name>A0A6A6R9E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9E5"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="255"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="473" mass="54521" checksum="1A384CF4FEE84865" modified="2020-06-17" version="1">MSYRNGDTAVRAPADESDVEEEALVNDYREQVQYDGGLDELDRVTSLSGSGQDIHAQLAAAATPLEFQATLETKFASYDNYCSLFHFILNSDGPVDLEVPSYYWAWDVIDEFIYQFNSFCSYRQKIALKADNLEEIQLLRDNPNTWGCYSVLNVLYSLIQRSQISEQLAAMKRGEEGSLYAGEYGNRPLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILVYVSRTKNFQKGAQYDSITKKNDQMYALIAICVAFHPTRLDDTIHTALREKYGEQFNRLQRGGPEALPLFEELFRSACPKFIAPTPPDFDNPEINIDPVEHHLKVFMDEVKNNMWSPTVKSYLKLYTTMDLKKLAGFLEVEPNKLRCWLLVNKQRSRQVRWSEGGLLEGELINSSDLDYAMEGDLIHVSEAKVGRRLVDWYLRNLARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9F1</accession>
    <name>A0A6A6R9F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_190697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="620"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2501116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="810" mass="88423" checksum="2E440B923D480985" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAH3</accession>
    <name>A0A6A6RAH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylamine N-acetyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_547304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAH3"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="328" mass="37007" checksum="328B474271ED6F65" modified="2020-06-17" version="1">MAPSAYSADQITQYLDYIGLPSHYHPSSPSRLPLDFDFLTTLHAHQIATIPYENLSLHYSATKEISIDPQVTFKKIVSDKRGRGGYCMEAAIFFNHILRALGFDAYTAGVRIRYRENGVPTGDYIGWTHIVNIVTLPDSTKYVSDVAFGGDGPTKPMPLLPDIVTPNIGTQELRFVHESLTQQTHDSAATKYWIYQYRNAPTAPWNSFYAFTELEFLHGDFEVMNHFTSTSKKSFQTYTALVVKFLMAREDDEEMRAESRAEGKGKGGVYGKVMLVGGDVKVNTDGKTRVVKRCETEAERVEALKDWFGMTFTEEEKEGIRGHVTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAW1</accession>
    <name>A0A6A6RAW1_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">BU16DRAFT_203510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <name>heme</name>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2501584.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="515" mass="58043" checksum="C1795750934923FF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB30</accession>
    <name>A0A6A6RB30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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            <begin position="406"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502005.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBF6</accession>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17302" checksum="A21EAA0FA9309D0C" modified="2020-06-17" version="1">MLSHRLPLIHMMIVFSTFVVRSYAAPTPTKRDSTKHTTAIAAGVAVPLGVIILAAVLFYFRQGLAALVCQKRPSKKQIPVPDSPPPKPPTSAPTYPKQAYRAIHPPRAQESLELATGREINEGPMMSPVSPTSPVSPLRNLPTSPSERAMNAFNFSLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBM2</accession>
    <name>A0A6A6RBM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_546902</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBM2"/>
    <dbReference type="OrthoDB" id="3238762at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025556264" description="AA9 family lytic polysaccharide monooxygenase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2501812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="314" mass="31312" checksum="243C77C4AAC96DA3" modified="2020-06-17" version="1">MKSLAISVIVALAAVHTVVAHSTNASTCVRLPPNNNPVTSVSSTDVRCNVGGAQGVSGKCAITAGQSVTIEMHAQNGDRSCSNEAIGGAHYGPVIVYMSKVADASTADGSAGWFKIFQDGWTATGKGTGDDDLWGTSDLNTCCGKMDVKIPSDIQAGDYLLRAEVIALHVASSSGGAQLYMSCYQLTVSGGGSASPATVNFPGAYSASDPGILINIHAALSTYVVPGPAVYSGGSEKVAGSGCNGAAATGVPNTTLKTSAVPVSTSVSAGGGNSAVCTAAKYDQCGGNTFSGSTTCVSGSTCVGVSAPYYYQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD48</accession>
    <name>A0A6A6RD48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_19157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD48"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="416" mass="45470" checksum="C631882CE0483348" modified="2020-06-17" version="1">MSTVFAGERFSTITPDDHGGYVYIATLMAMTYSSLAFITRCFVKKRMFGAEDWAVAVAQILFFGQFAAILSSSSAGLGKNFDLLDDSQFFDVFRALFANQILFYLSLCAAKCSVVLLIQRLFTRDMKNFWFICSVFFGLAIAWGFASALLVSVGCSASFYTLGQVEPRCTGYLTRYKVVSTLDIVTELLLVLVPVYFLSYIQMRTEFKFRVVLAFAFRLPVAVFSVLHIIALSHALRASNPGVALANVALYQQAQLGYSLISATIPTLKSFVKSFDTGLGLQVGYSSNPSSGNPSGQGSSGAGGSGRRRPAESYNMSNLSKGSAGGSVDGGEGRVKYSLRRIGKRVSRVNEATANGPDAAQVDLRPEKLKNTTNIYHSTTHEEDESRRSATGSEEMIIRREVEWDVVRDFAGGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDC4</accession>
    <name>A0A6A6RDC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_18086</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDC4"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025379889" description="CFEM domain-containing protein" evidence="18">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="19">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="213"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2502745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="326" mass="33929" checksum="8A53DC1A46237C91" modified="2020-06-17" version="1">MTRLLLLSTIYSIASFAVAQYPSCALSCLDNITEINAAGCTATDAYCQCTNTAYLEEVTCCIRGACDSADQTTAFNQAVYNCATWGVTLNTHVSVTCSSATASAASTAAANTAIASTEAPSVATSSAVSYFSPKPKTYKSKKKHGLTSGAKGGIGGGIALVVLVVTALSGFLLKRRNSKKAAMIAPGAPATAIVPGAPAAYVGKEATTVAVEPVPSPAPQYSTQGGPYAPPMQPQGQYPQPIYTPQPQYPAPPQQQYAQYGQPPPQQFQQPPPQQFQQPPPQQFQQPVYSPGPELQGSPIGQQLQQNFTSTELPGAGAPQTKHEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDG6</accession>
    <name>A0A6A6RDG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_576669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDG6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="14407" checksum="1CD6C4DF20F0A225" modified="2020-06-17" version="1">MPPVFAETTTISASASASAAAYPSSAAVVLCVCACETPSSPSPGFWASVGSFHYGVGQSAWAWGGPWLVYSCLGKGSSQSAVLALMLTPGVLFRSKEPENGDLVSIVLILISTRESGKSRKFKITLWRLSDCVTNSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REP1</accession>
    <name>A0A6A6REP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_533318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REP1"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="214"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2503031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="41413" checksum="5178885ADE531A06" modified="2020-06-17" version="1">MSKEPKDKQAKQEKEEKRARKEAKREKKRLAEEAAAAVAEPVQAVQEVDAKGLKESKRSKKRKLEDEVAEEPKKKKKSKKSSNDNEAMQDAAVAPIEAAEEVKKPKKSKKAKKEDVIEDDAAVTSTEPERESKKSKKLKKTKSEADTSKATEKATNGVSEVDGDVSESQLKALKKKAKRDGKAGKKASNGVSGETPADSEVADADAPVAKKQRFIVFIGNLPYSATEESIKQHFIKIRPTSIRPRKGYAFMDFNDYDRMKTCLSLYHHSSFDDGTSPAREINVELTAGGGGNTVERKAKIDAKNERLNEQRERRKVEEERQKNEGDTKGSRPLSGKKAEKTAEKKPRPTPEKKPAKGEAHVGIHPSRLGRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF18</accession>
    <name>A0A6A6RF18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_521893</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2503309.1"/>
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        <property type="entry name" value="ADH-like_N"/>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2503309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="38151" checksum="F1AF2934A41B337C" modified="2020-06-17" version="1">MPSAIAIKQVPGKPGQVYYPLEKITIPSPQPSETQVVVSLTAAALNHRDLFIRQHLYPGTTFGVPLLADGAGIVTSTGSSPSAKKWLNKRVILNPGLGWTSDPDGPEGPKGYLIMGGTKFNPAGTLAEVVLMEAGELEEAPTHLSDAEAAALPLTGLTAWRAFFTKSGNAKPGRNILITGIGGGVALMVLLYGVALGCNMYVSSGSEEKLAKAKELGAAGGVNYKEEGWEKKLVELLPQDRKYLDAIVDGAGGDIVSKGVKLLKAGGIISIYGMTTSPKMPWLMSAVLKNIEVRGSTMGSRKEFADMVDFVNKKNLKPVVSRVVKGLDVAEIDGLFEDMKKASQFGKLVIELPSSGNSSKL</sequence>
</entry>
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    <name>A0A6A6Q7C1_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="42220" checksum="8AF87F44533ACEB5" modified="2020-06-17" version="1">MRISPFRVRLDKSLSNVISKHQLRRVSESSNIFLPRYVRRAFWETFDPTEGATNPRREQRLQTLVENRIRFEEWYEPFRRVDEGRARLYEVLTQCPFPVLLETRSIWRPGNELDRDFLHIRRKLYPVLEDLQSEKYRGNMKIRHDAASFFELAIESSESTEQAFRSLMTQSPNKATLEKIFSQYLLFGDPYNGVSRKLWGLHKTFNMVLRTSMKGPSSHTGSKIRKPGAKRPTSPVTGSDSHGVGSKFDQASSDQFATWVQELKLLKELQRNTSNSEFTSNRSPKLVRKFPEPPSTKRQIIRKHTSVGKLVRKFPEPPSTERQILRESISTPESRRGEVVRHTLAPPSLEGQIFRNYRSKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7K8</accession>
    <name>A0A6A6Q7K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="12" type="ORF">BU16DRAFT_532322</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="571"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="825"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
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        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="966" mass="105567" checksum="31C40D7E8B47A261" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <name>A0A6A6Q961_9PEZI</name>
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        <name evidence="9" type="ORF">BU16DRAFT_519776</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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    <dbReference type="GO" id="GO:0016020">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="376" mass="41867" checksum="8FE68B88C10C8B9D" modified="2020-06-17" version="1">MDPSHVDPAVATEQSRQNTVTVVTVVMTFFGFTFVALRIVTRQFIVRNVGADDWMSVAGLVLILAYMAEILALRPNGMGYSGATLELDQMINLMKLTLGIEITYYCLVYCIKMSILLFYLRIAAERIFQILCKATMALLSMFVTVCIVVCLVQCLPLHKMWDLTGLVHGRCLNTTAFFYSTSGFNIVTDIWMLALPLKTLWTIQRPKREKIALFIIFGMGIFSTIASIIRLYSIRIFTESKDPFYDSVQINLWSIIEVNIGIMCACIPSLKPLISGAQRERARAVTKRSGYTLHSRDKSGVHSNSFKGSREGEPGGSSEASPIDGYKMDSFVAVKQQAKIGMSQPTHGRMPSNDATPRAFGSSQEQILAPVDAQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q9A4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
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    <reference evidence="3" key="1">
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF20253"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2488639.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="785" mass="88548" checksum="F80CA3DB37ABD587" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q9D6_9PEZI</name>
    <protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488624.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="18689" checksum="EC1D2EEF7BE818C8" modified="2020-06-17" version="1">MASSLGIYRQPSLTSDPVEVDPANRGTIVRVALGVEALLNVPMAPLVLLYPAKFLSLVASDTSQITPLAEMATRFYGTMMVGLTLPIIYGAFNSRGAIESRPTTYLTLGGVEAGFLATALWVICGPRAASGFAPDIAWSIVKQIGPAFLWHMFVLHTKPQWFGRYREAKRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB19</accession>
    <name>A0A6A6QB19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_623103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB19"/>
    <dbReference type="OrthoDB" id="10308979at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="262" mass="28812" checksum="FB72B234DF621C2F" modified="2020-06-17" version="1">MTDGEIKAPKTRFDDKLSPPFPENPLSTYAPAKWPEALSREFLHFGANYYTSPPKGAPAIAQRRESATNLSAALLAHYCPSRVGWALHIDTTGSLSATARLHRTTKSWCAASLQLDDGSLTHIIFNTIADRTDDATKALATKEDRAFWHHLERWGGLPMRLLPTPATKLGGTRIQKVVVGGEEVAHALVVLVVGTQFEFYTFSKRDGLGDQLVPWYGGGVAEPVVRDGDQERRVTNVLMADEEDMRGVDAYIEAYLSLMGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB86</accession>
    <name>A0A6A6QB86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_472682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB86"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="125"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2488893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="552" mass="60276" checksum="AA3539B5698F5D50" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBA6</accession>
    <name>A0A6A6QBA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_575696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBA6"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000007">
        <property type="entry name" value="5-formyltetrahydrofolate cyclo-ligase"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
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        </location>
        <ligand>
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        </ligand>
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            <position position="54"/>
        </location>
        <ligand>
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        <ligand>
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        <location>
            <begin position="169"/>
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        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="240" mass="26393" checksum="A2B039A87BE3E4A6" modified="2020-06-17" version="1">MAALKNLKKELRQRIKLVLAGLSQESITSQTSNAVETLLSMPEYKAAKRISIYLSMPSGEISTSGIVHDALKEGKRVFIPYTYKMGNPREGQPKSIMDMLELTSMNDFASLKPDGWGIPSLDKDSISDRENSFGGKGLTDGTLEGLNEADSGLDFIVMPGMAFDSSFGRLGHGKGFYDFFLERCQTHSTETSARKPFLVGLALAEQLLTAKEFVPMDTTDWRLDALVLGTGQLLRRDDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QBA7_9PEZI</name>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="26021" checksum="64A2B80B6C76B203" modified="2020-06-17" version="1">MPSSTVTLTGNALPAYLRQRSCDDVASTEHFSVAGCRARLAMRFGARLIAPEKAMQGRAQSPIRRLRRPPSDAGRGGESFLMRCQRAARVRTTLPKPLPRDRSPLTGVAVVLAVKQPSTLSDPMQVFGSTGKERAPESQPWERLPASPRSLPASSLHARSAACDPGAAHLSSLSTLGRLIDRFTASTAMPPGPAAVPECRSLSWPGIPTWLACSPPDSDNPKAYLGTFTVAAYEWPSAVSSCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QBI5_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBI5"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="20028" checksum="AA2A555B1FFF27CE" modified="2020-06-17" version="1">MWTWSLFHADNEGNIHTRKCSRFQGRLQNLCGPCDMRFCDRQVHCYKIIIPYKSMNDHGSKGEVLAGWRTSASAAWHFLNLPPQFFRPHFHLAKTRLDHVSAILHHFRTQAHHTNTAREAPLLLSTIPSSALIEQRVDFASQSWVRFPSCGRRKAETWPQIARCERTCLARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBS1</accession>
    <name>A0A6A6QBS1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BU16DRAFT_531945</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2937326at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="156" mass="17095" checksum="B1B7B3B307BA69A3" modified="2020-06-17" version="1">MASKIPTFPRTVFTIIEPLSTAAGYLGPLLSPASFVSSQSPFEPPHQLYLTEHVLALQLGNCYGLLALLGLFILNTTDELKTVKAYLLALWIADIGHIVVTLWGLGVDGWSVSSWNGMAWGNVGFTAFLFAVRSIYFLGLFGDDEDEEKVEKVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCC1</accession>
    <name>A0A6A6QCC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_441880</name>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCC1"/>
    <dbReference type="OrthoDB" id="5387995at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="142" mass="16209" checksum="E023566BFB8B56D2" modified="2020-06-17" version="1" fragment="single">TRAPHHLTTTPQKRSRALTDVDGEYSCVEKKKRRLRLFLITSRLSQPFSAPATNIVDRGSSKIAVWAKQKALGRNLLRKAAILNRIRRNAIRTHTEGRGISCVLDQEKEQKQLELARMAFLYGSHDTHTRPVFQRPPDFPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCL5</accession>
    <name>A0A6A6QCL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1264-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_518359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCL5"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="229" mass="25723" checksum="302A1A15F7471C85" modified="2020-06-17" version="1">MSNESLPTTNAAAGTPLTAKSHILETGAAATQNFAPVSSICAHLNAFHAYVEDPTRCVETNHYCAHLNEDVRQCILYDSPDKNARLIGIEYMISPRLFEGLEAEEKKLWHSHVFEVKSGMLIMPKPQLVPRVAWEAAETAEMEEVVHLYGKVYHLWQTDRGDKVPLGPPQLMGSYTAEGQMEGVKEGGFEKLVGGRDERFGEDWRRKREIREGIEVPEISGEADVMWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD44</accession>
    <name>A0A6A6QD44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_575475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD44"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="38294" checksum="FA7A4CD9D3ACC59A" modified="2020-06-17" version="1">MAVDAAFAQRLPKIELHAHLTGSISRGTLHDIWRIKKDEDPSLALPDPLVAIPPGVVIDLNTFFPLFSSYIYQLCSDLPSIEFSTKRVLSDFQADGVVYLELRTTPRASPAHNISKDLYVSTVLSILRSHNADPANTLHATLILSIDRRNSLPEAHDTVDLALKHRPFGVVGVDLCGDPAVSGIAKFAPAFQRAKEAGLGITLHFAEATASATDEELRELLRWQPGRIGHVIHVKEEIKDEIVKQGVGVELCLSCNVQLKMHGDGGYEGHHFGWWRGAGVGVALSTDDVGVFESPLSEEYRLAAEHFELTKDDVRKLCEGAVETIFGSEAEKERLRVMYREWDGWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDT7</accession>
    <name>A0A6A6QDT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_153254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDT7"/>
    <dbReference type="OrthoDB" id="10638916at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025653224" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="20640" checksum="A196358BA30144EF" modified="2020-06-17" version="1">MLPSINRRFANIALLVPYSALAQLTSTAIYPTDYSSFCTDPSRISTYDACITSVSSAYAGCSDTDYGCLCPAVKAEFNCMTAYCPQYTGGVCAVSKAAHDICVAANMAAPTVKDYACPSSLVESYFGPTDVPSGTATDAPTAAKGTSALTKGSKAPTTAGCTVAGSTPTSTSGAMVALGSPMTGTLAALASMLVSGFGRMAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE59</accession>
    <name>A0A6A6QE59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_585079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE59"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="301"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="472" mass="52841" checksum="4EB90300DBC7AE27" modified="2020-06-17" version="1">MASYRAISTSKRLCHSVPSATRNFSCKSITARNTTRSLHATAKRFTDGVFRELTAARTGRTPWIEAFRRQQADKQDLSKPSGIPQVPPNRDLKPKKMSDSYHSVILPLAQDPWLLDTYLNSSGQIRLGTLFMDLDALSGVVAYKHTGDAVTTVTAACDRIKINSPLTEICDLELSGQVTYATGRSSMEISLQVAKAPKNGEKVPKEDVFIECTFTMVSLDPGTKKPVPINSVVAETTEEKELFSLGEQHSNQRKQRSKTSLIKYTPNDLESDLIHAYWQHQIQFHDPNDPNRKPKNAHFMDSTELRTAMIMQPQYRNRHNFMIFGGFLLKQTFELAFSCAAAFSHARPVFVSLDPSTFQNPVPVGSILYLTARVVYTDPPLIAAPGESYDAESPYTRVQIRVDSKVRNVEHGETKPTGQFNYTFTVNKNIRVMPRTYGEFMMYIDARRRAEEVSASLGDAEAPAITGESVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE68</accession>
    <name>A0A6A6QE68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_494374</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE68"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="435"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2490399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="923" mass="101519" checksum="E250EE759F85EED7" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE79</accession>
    <name>A0A6A6QE79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_148782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE79"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="236"/>
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        </location>
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        </source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="454" mass="48882" checksum="D50CC0E0BFFB965C" modified="2020-06-17" version="1">MSGSDELRRLDQELRRLSDERLDLQREQESVVKQIQPLEKKTQGLYAQQQRLEHRSIEIANEELAIRQQRMVILTKFNPKLDIVPAGQSSAQETSTKATASKSVKKPRPTSKARGKAKSGPASASGLLHNLKSAAPANQSPASSTRWKTRGGLLAASPGTPPTTSPFMPEDPVANSATISRKRTRAVVDQEHESPYIPRKRSNARKGRQTITSMTAGVLPENHEAPHTQPSIPAAAAEEPTVENFTHDSSKWPTVVLKYGQQNGGEWVDLRCPECGCNAPTSGIGFFKGANGMKFHMMSAHNYKATESFILLAQTHTSYTTEQIFHLNTGGPLAPTLPLIPAIGKAGKTTESGDRKSGGGLVAMAPASEKTGLQGAAKKKKGHGWSAVTSGPRRKSKPSTLGQTQLSFSEEEAPQQSAESGAALDESQHARDNDQEAANGQHDDSTLTAPIDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF22</accession>
    <name>A0A6A6QF22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF22"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="42537" checksum="97B0C4E0CD8CAF5A" modified="2020-06-17" version="1">MHVLRRAVLSRPKSLCRTSIAPVVRLRVMSTSETPAKKLKMTGPLIGTHNGHFHADEALAVYLLRLLPTYASSPLVRTRDPSVLSTCHTVVDVGGVYDASANRYDHHQREFSAVYPGHNTKLSSAGLVYLHFGKDIIAQHTGLDVASEDVAVLWEKLYTDLIESFDANDNGINQYTSSAIAKAGIEKNFEERGFSIASVVGRYNRAPLPTSFSDTAPQAEEDARFARASEFTGEQFILDLSDAYKSWLPARALVTQAYNDRLQYDPHGRIMVIHYKKEGVPWSDHLYGLEKRAEQKPDVQAQVLYVLFPENGDADSKWRIRAVSKEGSGFENRKDLPDAWKGVRDEKLDEVSGIPGCVFVHAAGFIGGNKTFEGALKMAAVAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG56</accession>
    <name>A0A6A6QG56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_445387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG56"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="94"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2491171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="35047" checksum="3C932F5857E976E5" modified="2020-06-17" version="1" fragment="single">EVKLVLMTLGRSLTPLRSFLHECKKQHEASVDNTTISYSRTEMSQHWGMSHERPSRPLSTIDLDEKLKTALVADINEYLSPLRAKWYSDRGIPYRRGFLFHGPPGCGKTSMAKALAGHFHLPLFSTSLSRNMTEGTLESLFRQLPKRCIVLLEDIDSAGIQREEMKQVVPEQPLLQAQAQQPEHYGYGMPLSCLLNVIDGPNSEEGRVLIMTTNTPESLDRALIRPGRIDMQVFFGPVSRKVAASIFRRMYMLDTPPSGVIDKKQEEELAEQADSFAAHVPELKFTPAEVQTFLTMHRTPEQAIAGAQDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGY7</accession>
    <name>A0A6A6QGY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_119461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGY7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="119" mass="13480" checksum="E66437F2B32D20BB" modified="2020-06-17" version="1">MPLVYIRYILNLRPTFAPTAALLRSFFRCCRSDMSRLFDLVSPFEEAVEGFAVLRVHLTAVFALWFHGGLSAAFCFCGAVRISPAVRIFSTIRILVRILRALNSAVWGRSPAASRSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHK6</accession>
    <name>A0A6A6QHK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_468499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2491691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHK6"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0051225">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP"/>
    </dbReference>
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        <property type="entry name" value="GCP_C"/>
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        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="177"/>
            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2491691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="912" mass="101326" checksum="4398D7084D83DA74" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI64</accession>
    <name>A0A6A6QI64_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_620939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5399006at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="26993" checksum="460899FF05CDB0C6" modified="2020-06-17" version="1">MVSNKFFAIVAGVGPGTGRSVAIRFSEAYPVVLLARSPESYNSVVAEINKAGRKAIGITADATDESSLKSAFETIKKELPDLKLAATIYNVRPNSRPSRKPFLELTLEDLDTSLNGNIRGLFNFAQSILPLLLGSVEHSPQPPTLIVTGATASIRGSAKWSVIAAGKSGQRILTQSLAREFGPLGVHVAHAIIDGGIDVPDATHYPRNEGTPDNRISPYAIAESYWYLHTQHKSAFTQELDLRPFIEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIJ5</accession>
    <name>A0A6A6QIJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_107908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="407" mass="44150" checksum="D82B96259F22A9CA" modified="2020-06-17" version="1">MAGAQEIRHDSVGHTVIALCIAFGAITTVVIFLRLFTRFYIIKTIGPDDVLITIASILSWAFIAATIMAVNHGLGSHIELVMLRGTQNMISYAQIVWLSSIFYNACLGFIKTSVLALYMRLGDRSLRRMAIVMTGVVGCQATANVLTCIFQCNPVSAAWDVTITEKKCVNINAFYLANAALNIATDLLTYTLPVKLVLRLQVSRNQRIALGVMLCLGLFACISSIVRITFIPEMLVSPDATFVISGAMYWSVIETNIGIAAASIPSFKALAKRYAPVLLGSSHNNQKYGSTGMKSGSGPFHKISNSTRNTSSVADNSVKLRPLSHRDAAKGGIDDNVKEIPQYAKNSVATKIEQDRASNDSEEMLNVPDGRIVARTQITTHVEGSDEETNSFYSHEDSAKAPAGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK59</accession>
    <name>A0A6A6QK59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_592311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK59"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="334" mass="35718" checksum="D2A1106F73862093" modified="2020-06-17" version="1">MAVHNIETTGKDIIAEYGGNAKGKTCKFTKLALARSSLYCFPNSIAVLVTGPSDGGIGAELLTTLAAVEPAHFILAGRNEAKITPVMKKIQAINPNVKLTFVELDLLENTSVRAAAEKIKAAVQGIDVLINNAGVMARQQFGLSKDGVEIHFAANHLGHFLLTNLLVDNLAKVNGVVINVSSMAYTLAEVNTEDPNFNDGKDYAAWVAYGRSKTANVLFTYGLAARYGDKFSSFLLANSVVDPEFLGEGFKLSGSRTAKFAAEGKEIPPTVPVSMQQSVATALMAALDPSLKAKSPAFLKECNIIEPLPYATDKDEVLKLWAVSEKLVGEKFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKE6</accession>
    <name>A0A6A6QKE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_466172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKE6"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24200" checksum="6784881C199CB870" modified="2020-06-17" version="1">MARTMGGGVVGAVIEDLTVEKLGAEFERLGRVWRSSACRAAVVGMLEAARGNGWSITEAVAFGTGSFSLDWAMRGRALWQLVVFVDVVTSVKKTVAIRMFAQDPLYTPLDSAFLASLGIAVETEAAKSHLTPSSFLYVPFVDWRILNLVILPGTDPALYIGNLIQGEMTALTHGGPAPLLEEANEVASGWLRGREGRRVPEFEGEGLEGLWCCWRREKGEGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLN7</accession>
    <name>A0A6A6QLN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_465981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLN7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="518" mass="58415" checksum="F0846611B3EF5F6B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMJ9</accession>
    <name>A0A6A6QMJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_583458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMJ9"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="151" mass="16746" checksum="97376DA4985BB2E8" modified="2020-06-17" version="1">MDPDAPHAEPQPSIIRWVLGFLLVGAAWGLTTPFMRRAAINYTPPTRPSVTDPRNSWLKRKILGVFWAVVDLLRRPAYAIPLLCNVTGSIWFFLLIGKAELSLTVPITNSLAFLFTVLGEWWAEGKVINRDTWIGMGLVLGGIALCVQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMT8</accession>
    <name>A0A6A6QMT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_528034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
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    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMT8"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="213"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="316" mass="34669" checksum="12A12C5FE6991C31" modified="2020-06-17" version="1">MADISVPEPFPISQIANRFLIFDVDAVTYARREHNITGVLVGTIAHMSQQNVFLGIPLELMPEEARLLVEQGHAYIADDVDVHNKGFLEMNREDRLAFLQAMDKQGMDAALNNQKKAEERSEKALQRKGLARKVQENAARRASEALESSSAATPTDAEADTSLFDSPPRSASPAISQAPNGLDPFFVTPTTSYPRLPTPPISPTTPLPHVPRTYPLFAYLHSKGYFMTPGLRFGCNYTVYPGDPLRFHSHFLATGLDWDEEFDLLDIVGGGRLGTGVKKAYMIGGADTSTNDVSDKGSGRRTEDGVRAFSIEWAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN50</accession>
    <name>A0A6A6QN50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_489597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN50"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="681" mass="74358" checksum="3DD4FDC597D1C47D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPZ7</accession>
    <name>A0A6A6QPZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_68589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPZ7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="17767" checksum="34DB73C52B41BE74" modified="2020-06-17" version="1">MSCIIRVISYLQPLLHMIPSSSSSYTSKTFHTQVHHETDPNSIQPNHSRQQQQTPSLQDFSHHLQTRQHLSLPNPSPFRSTHLHPQPPAPSTLSTRTPRIRPIRRCKAAHRRTHRHDLPLACPAAQQDIGIIPAAPFPVFAALRQRARVGGVREGEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQG5</accession>
    <name>A0A6A6QQG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_426231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQG5"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="443" mass="49224" checksum="92F2BBB871BC4C7D" modified="2020-06-17" version="1" fragment="single">KPFKVVIIGGSVSGLTMAHTLERAGIEYVLLERGSEVTFNGGASIGLQPHGLRIMDQMGMYEDILKTTAPMIRADHRRPDGTPIAKSEFMLQIEERHGYPILFFERAEMLEILYNHLPDKSKILCSKKVVDIQSNSEVATAITEDGTKYIADMIIGADGVNSTTRKMMWNMMADTDPDLVQKEATSMFSDYSCTFGVSIFESDDPELRPGVSHINYGEKQSHICIISTRNRKFWFLILKHDKRYYAPNIPRYTAADLEASVLKHSGVRVTEHSTLGDLWKHRSKCTMVCLEEAMFDRWSHDRLVLLGDSVHKVTPNAGHGGNTAIESATVLANLLYEAKMGTRKGASLSHEGLLAIFQEYQASREVRVANACQKSSAATRLQAMDNLLWKSGALQIVPMLGEDMEVNAASSLIMGGEPLKFVAYKGKQGSIPWDGWDLTTLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQR8</accession>
    <name>A0A6A6QQR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_618743</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQR8"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10 17" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025541003" description="Endoplasmic reticulum chaperone BiP" evidence="16">
        <location>
            <begin position="38"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2494745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="678" mass="74056" checksum="BC6DC613ECB15680" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRI9</accession>
    <name>A0A6A6QRI9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527775</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRI9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="160" mass="16753" checksum="1D65A7A437984B18" modified="2020-06-17" version="1">MVWVSTQGKAEGQTLAEVPVPVGKKVVAFEERVGREEEGREGARRDADVPVPRGAVELSDSVWTLSDADTVVKTVPVPTKLVEFAYSVGAASEADAGAVPVPMRMVEFADSVGTSRDAVDTAVLVPSGIEEFTDSVGARREADVTAEPVPRGSVALSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRW3</accession>
    <name>A0A6A6QRW3_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_511503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="396"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="541"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="548" mass="58300" checksum="6F7D8F20F69570E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS93</accession>
    <name>A0A6A6QS93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 269.34</strain>
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        <text evidence="1">Belongs to the peptidase C2 family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="449"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
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    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="992" mass="113309" checksum="DBE4D29C99C64187" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSG3</accession>
    <name>A0A6A6QSG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_379749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSG3"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="378"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2495106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="569" mass="63216" checksum="A96058D26E99FC13" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSS7</accession>
    <name>A0A6A6QSS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSS7"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="80830" checksum="94F1BAD04C0D5EF1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QST0</accession>
    <name>A0A6A6QST0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_461998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QST0"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="202"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="37782" checksum="9C554ED81466D753" modified="2020-06-17" version="1">MTDSQKKNVLVIGGGAVGAIAALNLEKGGLAAVTVVLRSNYEVVNKSGYDIESCDHGVLKGWKPTHVRPNVPDISKEKIKPYDYIICTTKNIPDMPPSLSSLLSPALPYENTTTVLVLIQNGLNIEKPLQDAFPTTPILSGVSLIGTAEIKPGKIVQDDHDRLLIGPFQNRSLASVSQIEASLDFVKIYKAGGKTNCTYSPDVEHDRWRKLVYNACLNPICAITGLDTGRIRLADGGIEGLVRPAMEEIVAAAKHKGVLLAPDVVDVMIDIDPLEIYLSPSMLADVNKGNYIEFENLLGEPLREGKELGVPMPTLEVLYNICKTVQWRTKEARHLVEIPPKKSAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUL9</accession>
    <name>A0A6A6QUL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_508436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUL9"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="322" mass="34813" checksum="1DE78E4E2813C3C7" modified="2020-06-17" version="1">MSSNRIKNVAIVGATGNSGSYMVSSLLATGKHNVTAITRASSNATLPAGVKAAPVNYDDPSSLVAALKGQDALVITMGTMAPPDTQSKLFRAAADAGVPWVFPNEWAPDSAHPGLCKDVFIFGKLAGAQKELASIGVSNYVAVTCGFWYEWSLSIPNSYGFDFEKKEVTFFDDGATKQSTSTWPQVGRAVAALLSLPVKPEGGNEEKSLEHFKNKQVYVNSFTVSQKDMLESVLRVTGDKLEDWKISNEPSHERWAAGIEAMKGGDRSGFVRMMYTRVFYPDDSGNFEKTRGVSNEVLGLPKEDLDEATKAAIKRAKEVSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUS8</accession>
    <name>A0A6A6QUS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_359308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUS8"/>
    <dbReference type="OrthoDB" id="5104731at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36905" checksum="0700F201D60EC846" modified="2020-06-17" version="1">MEGPNSKGKGKRPRVLPDDELDDEQKEERKRSRQRIPLTNEDRIDWAKSDLRDHIGVVAGKERHPRNPVLFFIELAPYSNRGAACQHVTCKDHIEAGSYRIAVKPGMNLYKNPDFYHVRCFEELVDFSQAAYLDRIIPVTRNYVSVRGLSGISILDGNNFLDGGAERLVLEWKWSMRKLMDRRDEVPITTEPDLDNLHRKAGSASYEFKPINGMPDHEFFTLSIMLAPIESDGVDDQDEWNLFERYLPRDFNNIEDFKKPHSLSDILSVWKSDKFLACANEDRLTDKAKEEKDKLGEKAIRAIRRLSAVPMPDIQSAFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVH6</accession>
    <name>A0A6A6QVH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_360299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVH6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="15559" checksum="2E766B94127C0352" modified="2020-06-17" version="1">MLTPSPHLHILYERHDCISLPLPPRRLRRRRFPQRRRPSRPRASGWRRRDSVSALDPDVFTPYSQFLATPHLLKPATPLLQLSTATSTRATVQATTTSGAMPLRAATRTGPTVRRSECTVSTSSSAVKWSSMKSQTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW58</accession>
    <name>A0A6A6QW58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_526839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW58"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="537" mass="57723" checksum="4E7F25B1440E2813" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWB6</accession>
    <name>A0A6A6QWB6_9PEZI</name>
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            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
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    </dbReference>
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        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496489.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="23615" checksum="7BCC89DD2605B6E2" modified="2020-06-17" version="1">MIPPFSTLLSLLGTFSALFALSFSCVPPQARGQSPVTIGTDGPADPATVGFNLNHIAIQISNITASRKFYGEVLGLRHIFTFEASEDFAVVYMGHAQGGRNGTGYQTGAEMARDQWNSEGLLELVWSSQNKHIDSAVFGMSHLGLVVPDIQAFQDRLLALKIPVEKKIGELPKKDFGLYFGLHGENPVLPPALKQPISGFVFVRDPDGYLIEVQVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QWC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAF2496404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="420" mass="48352" checksum="4D73487BC4070CF7" modified="2020-06-17" version="1">MPRQSKIYRPSRLELLPTELRQHVYSSLGFPILRKVMYESFSWGCPAVGQTILKSVNFHTQEMMALSRAWFDVLYPETGELHTYSVVEHEALPELRAVLCLNTFFAMDVWSLFLNNVEAVFDFPLGNKLWRGWESPFQWNLSPFPFQVMTSITLTDEIGCVSNYTYSYISKPFSELDTFKESHRGRLAKFALSIRYVAQHCPSLRSLTLHPHHHSLNNTKLSALDIIPSTLKELVRKVPRLQSVKMEFLCCQLSEAEESEAHLESEESGDDLLKILLHPIAIPSTFTPYAIPEYLREDAIAAWATDMLRTMRKQECERDEVLVDMRRRECEPGHHRDRGVKCECGHQCEKRESQAYYWIQLRKEEKVAAEGVGEGVKSLLGAEKSDGCEGCYWVRNRLDNIAKSWNGGLVSRLRSILKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWE4</accession>
    <name>A0A6A6QWE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_581441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWE4"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025356718" evidence="1">
        <location>
            <begin position="23"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="418" mass="44458" checksum="1D7E6C2F39CF00D2" modified="2020-06-17" version="1">MSLVFLLALSIVFLATTSPSLAVPHSSSIPSIPSIPNIADFLRDHPLYTRPIQPITTILAIGDSYTAGEGANGSADYITTSAGCDRYKQSWPLQLVANPAWDSFNSRTPDLVFGACSGAKMDDLVTKQLKPGIPNEAAQYTKIGKPQIAVMTIGGNDANFFGAINDCILHITPPSNSCPETLASISTTLASPAFKSHLATTLTAILTTGRAAAAASPPESFQLYLAGYVPFFNADDAGCDNVSWNVHGGSEPKLTRGLRESMNGLVELLNKVLAEVARAMRPWGVFYVEGFEEAFGGHRFCEPAGVGYLERPTGVGTWFWHIWSGDGGAGELGGRDGAGGRVGKEVLEDLVSEAVVRGRDGEAKAPVATLQRRMESGELAGRDVEDVRRALSRVFHPKGVGYAPFAKAFLDAIRSNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWL7</accession>
    <name>A0A6A6QWL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_561309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWL7"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="237" mass="26731" checksum="0C66B5003E7B23FD" modified="2020-06-17" version="1">MADLTATLRRLGLAEYHDTFMRNGVADWDTVGMLTEEDLKELGVKLGHRRILQRAATDTHSHEASRKPSEEEDTNSNTCSEYPTKSTRPIQASDHSCRLSQAMDNYFGLILSKDTSERRKFDNFLSLAPHPTLISTFHLREILLKYTKDYVLSEVLIDGHLSDGMIDILRETNVFTDAYDFPRATSRSFSVGYVQGQLDAVLAAISPDPTRLEEDLEDATMSMLEDFDSPSAEDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXM6</accession>
    <name>A0A6A6QXM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_344907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXM6"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="37489" checksum="8DCF0320C8993C42" modified="2020-06-17" version="1">MPTKTVVTVNSNGRQSASFVRVASAVGWQVRAQMRDKNGIVAEELSNLPNVTVFIGALEDPKFLADLFKNAQLAFINTTHWGDEVAIGRSLADAAKKAGVQHYIFSSMPDHSIYNENWKPLPMWAQKYTVENYIRQIGLPATFVYCGIYHNNFTSLNYPLFRMELQDDGSFVWQAPFHPDIPLPWLDAEHDVGPAVLQIFKEGPRKWGGKSVALAFSELTPKEVCRAFAKGLSRRVKYRRGSIEIAVPVPAGYRHHLQALEDTLGRQSAPYFGPELEKNCTEQALELWEGYRDIEEYAREVFPVEESANGLTWMEEGETEQPEVELDFQGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXS3</accession>
    <name>A0A6A6QXS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_458179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXS3"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="528" mass="56562" checksum="5FC31AFE7927EEDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY72</accession>
    <name>A0A6A6QY72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_458669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2497024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY72"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="654"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="754"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2497024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="799" mass="89128" checksum="4BF6E4EFF9AF71DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY85</accession>
    <name>A0A6A6QY85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_352349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY85"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025636808" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="17738" checksum="05FEE57F23E04546" modified="2020-06-17" version="1">MYSLTNVVLITVMGLTSLTLALPAPPGYPYPSSSEKPLTTTTVSNSGVLVWTPSKTVETLSATTSSKSSAKPSSSYWPTSPKTSSSPSPAPSSYWPTSPETSSSPSPTPTPSSSLTASSSNWSKSSSTPVVTTTPKPTSTPTPSPTNNCISSSGIQLCFTARSTSGGSFVTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYW0</accession>
    <name>A0A6A6QYW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_482775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYW0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Ezra D."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S8 family.</text>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="195" mass="22343" checksum="BBB222D70C47F601" modified="2020-06-17" version="1">MIKPIRVWLTPAGPNPYKVIIVLEELRVPYETKSFTYPEVKKKPFTDINPNGRVPAIEDPNTNLTLWESGAIVQYLVEQHHCNQWLMFQMSGQGPYFGQATWFNFLHAEKIPSAIERYNNEVKRVVGLLDSCLDGKQWLVGDKCTFADLASAPWNNVVGTIFSLPTDQMFDEFPNVKAWHDRITSRPSLMDEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Y6</accession>
    <name>A0A6A6R0Y6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_482700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Y6"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000673">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="255"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2497600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="369" mass="40817" checksum="4F759219C49F355C" modified="2020-06-17" version="1">MSHSKRNTSLAFFTSHERAELKSTWGSQSTRLTRDSFLTFGSCQLCLLPAVDPVACPAGDLFCRECAMNNLLAQRKEIKRLEKELEKQRKEDVDEKARDDDEARERAVKDFEAVQMGLEIKLGAGGKVIGREGGKVVVERVEDLKEGEDAAQGRGKKRKFEIDEGELLRIAKEERSRAKLALDEERRAAHPHLPSFWVPSETPSSNHTTAAPRKHNPTCPASSTSAPHDISLKTLTAVQFTQDKPSDGTKPVPSCPSCRKALTNSTKACLAIPCGHVLCKPCVAKFMTPHHRHHRDAHDEDPEPETVHCYVCDADLSTPPEKKVKHGKEHKKDKERGLKPGLVEIRSEGTGFAGGGKNVVKRQGVAFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R279</accession>
    <name>A0A6A6R279_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_308113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R279"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="17030" checksum="68126FD1DE8226E4" modified="2020-06-17" version="1">MADEYAAELKKKRAFRKFSYRGVDLDQLLDLSSEELRDLVHARARRRFNRGLKRKPMGLIKKLRKAKQEAKPNEKPDLVKTHLRDMIVVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLGEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2H4</accession>
    <name>A0A6A6R2H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gpr1-like plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_615511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2H4"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="29261" checksum="3A3DA91CA471A852" modified="2020-06-17" version="1">MPTSSNGTPPIHDEKMPPSDPLAMHRAPSVTLSPELFEKYYLSPQTPVHGSLRKTFANPTPLAVLGLAMALTPFSCDVMGWRGAGGNGAASIGSYYFMGGMLMIIGSIGEWIMGNTYPFVLFGAYGGFWLSFAATLTPSLGAYGQYSTNYSVEHPSAGLDDSAFAASFGFFLLAMAVLSLIFALGTLRLNICLMVVEWGLTLCFTLLTATFWHLAQGNAGVAGKCLTAAGAFGFVASAGAWWILAAQILAAVEFPISLPVGDMSGVFPAKKVKVESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Z2</accession>
    <name>A0A6A6R2Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_536332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2Z2"/>
    <dbReference type="OrthoDB" id="3927840at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="445" mass="51872" checksum="389A90432149EED3" modified="2020-06-17" version="1">MTTPIDGLPTELFLEVTRYLRHGDLFQLMQVSKPCRQILSPILWKRIELHRPSYHSDYAYPHSHTDAGCESRPYMHLPEWEPNSYLDKYHADVAKAFIMMFESMPKDSSERLRRLASQVRWLCLHVDPYEDDSVTRNCWNIFALFTNLEYLEVDAAWTAYNEVEPFNLGAQPLAKLRAVKLRGYVPREVVQYFCQQPSRIVDLELAVLDNPIGGTLAYERKNPPPEALEPPEDYDGMTEEDLEALNDEEDFEEEEIAPRPLCWMPEGLGSQFTFLTRLWLCKPGEPRHRIFHETYYSMPSDQRTLDAWVSIIRAARATLVYLTLEDRLAIENIETDSTGSNEFMQYYSHGPTYHRFVATVLPVLMEEAQWPELKYLQLYGLEIHDPTNSHTRDPHVNIRTKLRQRHPYAEVETYLGRRMTFDSTTGEVGMYGGDGIGWDCLDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R333</accession>
    <name>A0A6A6R333_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_571119</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2498762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="29467" checksum="6D4727DCF0E3CF1D" modified="2020-06-17" version="1">MTAEVQRAPGDLVPPAASPAFNFSFSDFLRREYRFGLDPNRPFCKAYMQGHCPLGNNCPDKHHVSSSYNNLVCKHWLRGLCKKGDACEFLHEYNLRRMPECSYYARTLTCSNGDDCLYLHIDPDSKRPPCPHFDRGFCPLGPHCANKHVKKDKLCPFYLAGFCPEGKVCKNGGHPRYPTDLKKPEVRVEKSREELERERLAREMEREKEEEREREREDRNPGQGGGQQGRFRGGWQGDRKKRRGGGGGGGGGGRNRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3S8</accession>
    <name>A0A6A6R3S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family solute:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_548537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2499002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3S8"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF1">
        <property type="entry name" value="ACTIVE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2499002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="554" mass="59868" checksum="1CA6631150AE7C48" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R411</accession>
    <name>A0A6A6R411_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_266301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R411"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
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                <person name="Bloem J."/>
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                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="141" mass="14999" checksum="E30D7C395612EB3B" modified="2020-06-17" version="1">MALRTSSDGQGSTERAFSHGRGGAGNIGKERRESFTSPTDLATPTLKSEHYTTGRGGSGNIAKNDPNHPEVARLAQDVEAPLKREPEGPHHYGRGGAANVAVVSEEEARVARENNAKVRGGSEERKSLLEKGKDILGLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R782</accession>
    <name>A0A6A6R782_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_523045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R782"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="283" mass="30972" checksum="8E1DA62C440D51E7" modified="2020-06-17" version="1">MATPGATKRLTKEYQAISKSPPPYIIAHPSERNILEWHYILTGPPETPYVGGQYWGTLIFPPDYPFAPPAIRMHTPSGRFQPSTRLCLSISDFHPKSFNPAWEVSTILTGLLSFMTSEEMTTGSVRATDHERKLFAARTRWWNSTGGGTSTRTIPGITSVQSSNTRGNGGIKAGDGGVKFRKEWPELDEENWRILKEKRIDPVSGMTAAPESSHGPCSPEAAALRRRRPGGSATGVGAVVQGGQVARDAGQSWLGRNKWRIVFGAFFSYILIARMLGEGVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7C0</accession>
    <name>A0A6A6R7C0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_556750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7C0"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="29961" checksum="AA7BF5ACE0649A09" modified="2020-06-17" version="1">MATSLVPLPDIATLSPRVVRILGGNPGKFSLQGTNTYLLGTSTHRLLVDTGEGKPAWLASLKSVLAASNITISAAILTHWHPDHVGGVADLLALSPHTKIYKNSPSAGQLDIADGQVLATEGATLRAFHCPGHTTDHMALVLEEEDAMFTGDNVLGQGTAVFEDLATYMTSLERMAAQFAGRGYPGHGPVIEEGRAKVLEYIKHRKEREEQVLAVLGDAGGKGITAMAIVKVIYKDYPESLWQPAERGVLQILEKLEGEEKVEHNEGEGTWAINRKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7M7</accession>
    <name>A0A6A6R7M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_245617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7M7"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="158"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="53671" checksum="81625DDFD7FF1052" modified="2020-06-17" version="1">MDSSPSALLKVLIPKIPFIFKTALLHSLWLSPTSSKWSLQTELVINILRQLIANPGKPSSISKQQYQSCKDPGVKGDIWISRVTAPVPLEDDLRQLLFKTIDEMKQGDEEYTQPPLLPVGAEWTGYRANVAKDAPEPSISEEQKYENLMKEVTSDLTVLYFHGGAYFLMDPSTHRPVTTKIARMTGARVYSVRYRLAPQAAFPAQLLDALVAYMYLLYPPEDAYHSAVPPEKIVFGGDSAGGNLSTALLQFLLQLHRSSASGELPAVTWNNKICTIPLPAGVALTSPWLDVTRSLPSIEGNVKYDYLPPPSITEKSTFPPDSVWPTDPPRLDIFCEGSALCHPLVSPLAAMSWEKSPPIFVVSGDETLADECSVFAQRLARQGVKVVWDRFEAMPHCFAMVLEGLEGSKMCFADYTDFCKRVVHIPGSIKTEGYFISAKTLAKKHVDVEKLIDISDQDALDMMRTAQKRRLAGLEREGKALPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7T0</accession>
    <name>A0A6A6R7T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_558199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7T0"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="27883" checksum="C2C68E9730797A42" modified="2020-06-17" version="1">MGLSLNGVLFLTGAGGAIGTAILLQFARDGCTKISAVDISAAALESTAAIVAAQFPNVELLQNTGDITKETDIDRIFANTVKKFGRIDYAVNNAGVGAQLRPTTEVPSSDYDRVLNINLKGTWLCEKAELAIMEAQEPLVSADAVVGRTPSRGSIVNIDSVLGMLVVPGNAIYAMSKHGLLGPTRTDALDFAKKGVRVNAVCPGFVDTPLVTDAVKKVLKPNIDKTPMGRLAHVQEIADGVAFLASERASYITGTALTVDGGYTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8M4</accession>
    <name>A0A6A6R8M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8M4"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="235" mass="27219" checksum="D5E2AAF8719D04D4" modified="2020-06-17" version="1">MDVHFPFNESGGLPEDFNKLLTGPTIKVVVGRSGEDDATWGIPRKLLCNHSKFFQKATDPSHGFKEALEGMVLLPEEDPEVFAHFVSFIYTGGYYIDDDAIAISMNNYDAPNAHAAIWMLADKLFSPRLQYQAMKKLYENYIPTNQGSIWYLLPHAVSFVFRNVPESSKLRLFMEDTVVQYWDNRDVVDMNWRDEWIKLCLDNPDFNKKLLLRLSYPAVQDGQYLKPMKHYFVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8P0</accession>
    <name>A0A6A6R8P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_546460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8P0"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="303" mass="34995" checksum="DF14AE1CC976D434" modified="2020-06-17" version="1">MGHTLYSPNPIIPYHNSVGQTEVKKFGGLLTSEFMPAPIGRSFQMRQTYRHNVEGPIPDNLRRLIADPRKPKGPPTHFHQFQTEYFKVEEGICIVEINGVPRNVTPDDEEISCKPGNVHAFYIHPDSPEKMTILLSASDTGMDYQLDRVFFENWYGYWHDALLYRGGLDLIQTLQIHDAGDHYTPAPAWMPFRTFFGYWACVIIGRWLGGLLGYKPFFKEYTTDWDFAVSKMKGNFFTRWNVHESYADKPSWEKQVEMSSHPKPTNAEYEELVTDMTETFRSSQREVNGALNGDTVTPLRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8S1</accession>
    <name>A0A6A6R8S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_500149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="133" mass="15081" checksum="824CECD7D11F983C" modified="2020-06-17" version="1">MASAAVEKHKYVKLSVYLKRLPDCTDEKFHSYWAGNHAQVAMEHDVFRKHVRRYNQYHIPPELKAAAAATGLPTLDFDGVAEIWVDSLEGWKEVQNNVDFVKAIAADETHFLAQDRAILIGYDNLIIGKEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R8V5_9PEZI</name>
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8V5"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30988" checksum="D2E4BD59868598F3" modified="2020-06-17" version="1">MSFTFSTMANTRNEQTSLKRVNIEAEIEQPSPKRCKLELSSASPSSSKINTETSLLLALPTELRLIIYKHVLDSDPPRQLSVWPTKPFLRFSKTDMPTLFHPSDIALPAVCRHIRAECAEMIYRHHINISVHTHICLRKLTRQLGEFGLANLTHLQISWADRADTESALRRRKLTVRALLAQYVRLEKITIALPPRGGAPTTMKPEDFVLLHGLSDLAKKGVKVEIYQHGASWDSLLYGVEWTQEENTWVDAVGAILEVVKGKKGQREKTSFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9G8</accession>
    <name>A0A6A6R9G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_546589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9G8"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="102"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2501289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="564" mass="62184" checksum="8361F5CB449A1460" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAA0</accession>
    <name>A0A6A6RAA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_196792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2501354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="448" mass="51126" checksum="5EF90CF757372976" modified="2020-06-17" version="1">MADSNATQRGASAASIDNDKLAQDLTEQFRQVLSTKRMTELTSRSVNSRSASPAPRDFGTPQPPSLAHNAPPPSYSSLRNIPLVPQPPQDARSIRFKNMLYSLSSLPVRWENPGLLDEALKVVPLENIYNEAEEESQILRAEAESLGSGKKAAWGYQDCVIRALLRWFKRSFFTWVNNPPCSRCYSPTIAVGMSPPLPDEQARGASQVELYQCSVQGCQTFERYPRYSDAFVLLQTRRGRCGEWANCFSMLCRALGSRVRWVWNSEDHVWTEVYSVHRKRWIHVDACEEAWDKPRLYTEGWGRKLAYCIAFSADGAMDVTRRYVRNSTKHAIERTRAPEAVLLHIMDEIRANRRSNLSKQDKFRLEGEDMRENRELRHYVISSIAHEVSRITTDDILNGRPPPRPDPDAQKALEGRQSGSAEWIRRRGEGGRGAPNQQNPHDRDQNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBQ6</accession>
    <name>A0A6A6RBQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_556258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2501786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="DUF7730"/>
    </dbReference>
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        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="107"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="301" mass="34578" checksum="2A49077DFEE96C5F" modified="2020-06-17" version="1">MQDLSSQPMELDPLEPISKQPRAHIVSTNTSESSTSSSKCYFFRLPTEIRLKIYYYALQHPHGDSDPAWLSPFKRPIIEVLPPDVRHKKDSSEVDMGIVYWGTELMTRLLRVNRQIHSEAVEVLYTKFVFDFKNDLANAAFQFLTTIPPDTAAMVRSIYVKVSIGCPEDEIVPQSWMTPRVRPSLDLHPGWIDICKAIVARLPKLRNVYVRAILWHKVILPIRMTQSQMEIAIMDILDTFSSIEHVQLLPALHACSKLNKSYAELYKAVQICQKKHADNRVSLSSMFKEIFDMDKLLGEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBV8</accession>
    <name>A0A6A6RBV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2500927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4582561at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="39452" checksum="F43A83D76C30DD58" modified="2020-06-17" version="1">MSIGYVLETAISVALIVVFILLSYRKTNRQSRWIRLLLANSTKAFYENAIFFSSGIQIASIVVLAKVNFGINANGQGAITMKITWSISLLTLLPLLPLSLGNFMFRESNKEQEESAEIIQTSSAENGDKIRETSGRVALTHKDEEDAQDRRRFFLFVLCWMLSVFPFLSRMVGTFGQSQIGSGSGAVVSTNDWALIEQECFKGVNDLQSSQETAMSAFGIGSWLFLSLIVIWKIFLSGIQRQHPNSKLASRFEDKSVFLDTYRPSESWLWMCVCIVTPLLSIFQMWTFFRLQRLQTQMTKASGGDDPDTDWTFGQIVAVIIFTPVLVEVGFVIRNRKMFDKVICEEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBX1</accession>
    <name>A0A6A6RBX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_1666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBX1"/>
    <dbReference type="OrthoDB" id="3941683at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025534346" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="235" mass="23998" checksum="681F9C6D7EF3C482" modified="2020-06-17" version="1">MLPQYILLAILSAASISAIPLNINLGAYSPALVVGDGEISFDSTQKASELMATLATGAVTAGQQQENTEQQGEAPAGEKARATPEEADLPAPNVRSPEARSLEPVVARSPAPAPAPELVPAPAPAPEVDVAARAVDELEAADLVAEATQWIKRDIAGFREALNFAREAMKNMPKVELGTGAEGSGVGVIVNAGVNVPADSAANGAPPAAGARAKRGVEVEENEGPRMTLVAITEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBZ9</accession>
    <name>A0A6A6RBZ9_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="27162" checksum="44AF75F283AA8C51" modified="2020-06-17" version="1">MAPLYAVGGAGHTMELRSDDTGGDATDQSLRTRSSTMAAIVLITVAGTLLVCIVSYFAIQYYRNPMNLSGFPIFGSLIRRRAARQAETRTDGRNESTQELNPSCRFSGVEEYHELRDIRIRATRPMAQHPRIQFPSRAYHRFADDVDTLPTYSPAPSYASSIPGSPRSVTHSSSMMSMVVEIDESSTVGRRYHHDRTRTTVTILPSQRLSHHMDEIGLVTSLPTEHGVQELGTRAQHERKGSQI</sequence>
</entry>
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    <accession>A0A6A6RC95</accession>
    <name>A0A6A6RC95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC95"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="29839" checksum="20BD07E76C51804F" modified="2020-06-17" version="1">MTMHMTRRELGEIRGQKIPVAVDSPNTEPARGCSGNDPIGRNITAQDADSSYIRGNAHLTKQAISFTASDNPRHVAVVRKPEEHIQVNPSLCLTLDEAALTPAQKAQVADAKQKSLARAVPSTPKHAKQTLLSDHGIRSSSPRCDSFNHAAASPSTGRGRQARATTTLPRSGPLSTSSRTAALTFKNEDVALRDNRDVNIASNDTPSSRSDTWPPSHHRTLPPLRKGPVGSEGSFYIWSKLAAELEDLAHRPGPQDQADSGRLKRSHGGAEGDAATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RCP4_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCP4"/>
    <dbReference type="OrthoDB" id="4694464at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="189" mass="20902" checksum="C1332C1838B017CD" modified="2020-06-17" version="1">MFPRRVFNREDSAADAVSLHSFVGDGADQSDDEQGMRSRNTATLDLDLYLDVDDGDEGDRGDEPAPDGYFVLACQLFSTGSYAVTSKGPLPPGFDRGDYAKAHHDLYQDRDSPSHSWQPWLSGRPTRFALPITIWLVVLFHLAVSHTSVTKVSAVHNHGLRLSIPGKSEYFEIADDDEEEDGMVMVSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDK7</accession>
    <name>A0A6A6RDK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDK7"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025672200" evidence="1">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="22543" checksum="96B19D6F0B7C0EB9" modified="2020-06-17" version="1">MLLSPSLLTLVILVTGQLAAGHGAIIKAVGDAGGNGTALGIDASTPRDGTRRNPFQQDTTRFQGDAEEACGETLGAGDNDPETGTAQVLATSGGTLPQITPGGEVQMTLHQVNGDGAGPYTCMIDATGTGTQWESMQVTANVPGKKGRDNDGATTDFPLTAAVAANQTCTGTVAGQSNVCMVRCENPARAGPFGGCVPVQMADTKAKRNIGQRFTKKIHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDL0</accession>
    <name>A0A6A6RDL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_447799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDL0"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025412815" evidence="2">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="54680" checksum="21ED6206396BF02D" modified="2020-06-17" version="1">MFSSTYFWPLLLLPHAAAQSTAKLSWHPPVASWITNLSDIINGTGTHGFIFNSSKLPQGTEYAGTYNWCNMPHARLESYPEVSQKYELDYVEVIHRHHKRTPYESNLFPQEVPPWSCTDTAFSYASGPTGPQAHHPADTSLETSYHPSNPFIAPVTTNWTCQFPQITHGGLEDSYQHGRDLYSIYHGKHAFLPDLDDQFIQFRVTNNRITSQVAGMVIAGMYGSDSLQDLDHSLGVLLRVQPYPIDSLEPGYPCPTAEDVYSTYAVGSNNTAWISHLSAAKPVFTTLDNASKIEANDTDWHVSFDHYFDNLSARQCHSLPLPPGISQDTANAVYRLGQHEYSLIYRALEPSLEFSAGSYGVWLAELADNIEKRWHRESKIRFRHNVAHDGSISRLLSVLQVETMVWPGMGAELVFEVYKLRSRENKDMRNGKRWVRVLWGGQELISSNPVLGKMHLVEAEVFLDYIYAFTGEKAVKVKAFCESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDS4</accession>
    <name>A0A6A6RDS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_613715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDS4"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF1">
        <property type="entry name" value="ACTIVE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73441" checksum="75BB097C79B63C9D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFJ4</accession>
    <name>A0A6A6RFJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_612778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFJ4"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF425">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="171"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503244.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="872" mass="96090" checksum="522B3FCBE429840C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFU4</accession>
    <name>A0A6A6RFU4_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_521938</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
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        <location>
            <position position="339"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2503354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="339" mass="38935" checksum="8CC6A3CE0A3FCA48" modified="2020-06-17" version="1" fragment="single">MNCQKGDIINAEKFISDFRGVCKSEDGMWHFRGHGQNLKVYSDYSEVPENELKTSIMVDLPRCAELYGSPDLRHAVFAFLGQFKDLSKRWSGLYEEVIVKAIGFFAKYQEQRLSQISETPSPIDNSMLITLALRCLLTSQEFANITYCWPPRLPGIDDDNFHGCISEAYKDTRGGGYSPRVEVWRLPKDTELPESTKEPCHSVLINTVRLAHKTLLRKDPRDWPFVFCTLCILSLVQHDLEIAGDYTDALASASQDFRQYLLALSATFLLCVKDNHPFNKAFDIEKYSLLVDDEEEAINTYEWLHAMWIEYSQEEYDDSSEYVDVFCAKLDEFSGGFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG22</accession>
    <name>A0A6A6RG22_9PEZI</name>
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            <fullName evidence="7">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_521949</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="277"/>
        </location>
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            <end position="554"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="554" mass="64069" checksum="190C98A94AC88FB5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RHE5_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="32772" checksum="B1ED53874EB58592" modified="2020-06-17" version="1">MHGMQRKHLAKQDDGGARTGDACPKFFNTRRQQVPRQLGAEPFDFSARCRSWRLWRVAGDTGDAASWRRACWGGAEQHPLRGLAGLAANTGTLARSNETAGPSVHVKLLRIPLQSAAYIPLLPPILTPPLLPLFFSASSASSTSLPSRLPPVCAASGFGPQTPILRAVPSAVPPPCCLAQFSARACTRLNLEPVVPLSKPQPEPLLDARRSTLCAVDTLTSSLHCRTAGRASIDRRYLYSPHDNRSRGPPPSLLRQTAISPPSSRSESSATCSVPGTKQRAFSITQTRGRHPSSVTRSRGWPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Family A G protein-coupled receptor-like protein</fullName>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
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            <begin position="30"/>
            <end position="48"/>
        </location>
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            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="44655" checksum="DB0977A2FB9BA4D7" modified="2020-06-17" version="1">MASNVTHGYYATTHAFPPHKMWSIVVAERVGSVLSVLGSLFIMGTFAWRAEFKKPINRLLFCASFGNILANTATMFSISVLALNHDNGRPTNACRAQGFLIQSFIPSDALWAACMAWNVYTTFFHNHTPQSLQKFETRYMVICYGLPLTVSCSFLIADSRTTAPIYGPATIWCWVTREYDWMRLAFFYGPVLAIILGTFMLYVIVFVKYIRTNARALHNIENPVPLYNFGLGFDNNLQDFSEIQAVTNIDVTTTETKRRAHADETTLSSFNSTSPLTSFAAEQHGAHNTHIIEEVQPMHNIVISGGQAVTPAEQAARNARTYLLTAALVWLVLLVVWIPSTINRVQGMINPKEPNYGMNLAAAIVLPLQGLGNAIIYGVTSRHEIRDICLRRRHRDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8M0</accession>
    <name>A0A6A6Q8M0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BU16DRAFT_568450</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="MU004204">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="295"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="570"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2488286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="616" mass="66683" checksum="0D3422881ECEDFD5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q999</accession>
    <name>A0A6A6Q999_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_531930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q999"/>
    <dbReference type="OrthoDB" id="3940621at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29816" checksum="355E9E39773C5D7F" modified="2020-06-17" version="1">MSLLFWSLHPLLPKFCESPSPFTAPLGLKVKRLQSSFHKSSTLRSFRKKHTSHLLFRGPSSSLSMSGNLAPGLGELAKLPLELRYMIYEFLDEDFCCHISEPLSLFRSYRHDPCVPLGVSRVSKTIWGEVQQLFYQRTNRDLRIRIGYDGWKATCHALGFRSDWSSPSLASFQRLILEISAPAEDDPGQALLTIRNISNFVTVLNAAPSLPPTMICFVDPTNNTTASWECKQFHRFAFFPSFFGPPFHTLAYNVRNPLYYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAH7</accession>
    <name>A0A6A6QAH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_567313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="743" mass="82152" checksum="91FC48A228E655E0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB67</accession>
    <name>A0A6A6QB67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_566818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="341"/>
        </location>
    </feature>
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            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="493" mass="55403" checksum="F5ECFB02DE60AE2E" modified="2020-06-17" version="1">MDLTESGGLAQSKQTDDDEESLLQPSQQHTPHPTPPPCHPPIPPLEPLLLNFPYLSSTEEPSTPTMCPSAVNMDPESENQSPVGWESMSAFMFGNTTVSYPPNILGLEAQVCSLRQVINANAAESARLSEEIAARDKIIDGLSEKERILELRKLELMHLGLMIQKRDDAIKERDDFINTLVNAPVGTVGTMCCCDELQKERQKFQEELEAKDKKIGEIKELYKKEVAAKDRAMESLKKQKRAEVEGANKRIKALDDIIDGKDLAIQAEVQVHKDLKVQLSAKTREANALTRRIEEMTKEAARLSKLKEKTWQKLDTSRSVATELELKLKREEETRELQVRKGIEEVVAPAYPISGNELRANDLLYETVQAKDKIIEELQSEIAALNISTELMAENEEKLRAKLAETTGQTLNTNNNFTVVKVKKGKKTKPTTNKFQVLEEPDDPPAPPDPKLYDGFTTNTGAEATLRKGPGGRRYYEKIARHETDRWNAHVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBY5</accession>
    <name>A0A6A6QBY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_472053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2489163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="360" mass="40041" checksum="F64F723EE94B4E9D" modified="2020-06-17" version="1">MTYAGAFDKGDHIDTGIGGARKINLDAKQGDGVFSEIPVIDLTDAASPSLEARKKVAQEIYDACVNVGFFYIKNHGVPDEVIKTVKNEAKRFFHDLSEDDKMELDISKNTEFYGYAPIKAKLSDGQVKKRMFESINFGYEPLMDPGASGTVDNGPSFWPAEEKLPNFKENVGKYYSSVMSLSRQLLHLFALGLDLEETFFDQFCKRPGVLLKLNHYPAAVPDSADNAGIAAHSDLESFTILLQDDVKSLEVLSKDGTWISADPIPGTFVVNIGDAMSMWTNDLFLSTIHRAYNKEGKVRYSVPFFFGADYDAVMETLPSCVDEARPLKYKPITAGAHVRMRLNMTYPKQKEEAQPEGIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCJ4</accession>
    <name>A0A6A6QCJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_622907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCJ4"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="515"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="625" mass="69261" checksum="28823A0F5FEA9DC8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCW5</accession>
    <name>A0A6A6QCW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_166050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCW5"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="271" mass="30315" checksum="3A5CBFF7A31BB8CF" modified="2020-06-17" version="1">MADRSGMVDPAIFEDLQARIDEETTVREELREIVQSLEKQNKAVQFILARAHSTPAYACTFGTSTLYRSAQLTTPVSKVISDASVAVEDQVAIISKLSQAASKLPYYKWNTMWSRQIQDATFGILLCGWLGGNGSDSKPGRLLTIEEVGGIMKVPVNLKDRDAFHLTIEEYLQALISLVDELARLARNSVTLGDYLIPLLISQFIKDLHAGFQILNLKNDSLRRRSDGIKYRVKEVEDVVYDLSLRNLIPKDEKDEKEETGGVVVEQPGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDD2</accession>
    <name>A0A6A6QDD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_168747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="322" mass="36627" checksum="041367AC1C8FE67F" modified="2020-06-17" version="1">MSLLCAKRPLDLCSSYMPPSKSRRTDVRLYQALDRIAPLPRSDFYNNPTFRVGPWVMNGGQRSQQFHSPQPPAPPPIAPSRLLPNATSDENEDVEMDDAPADVTKPLDSSDADAYSRLLRASTTDLCRDIQPGGEYSTITLRMKDFIKGVWRLARLPYGYEFACDTLVWFSISVLHRTDSPFVYMLNSQRQSIYFLLDDAMLYIALEWWEKSAIWDVWTVVKDIRLGLSAGKVEWWERGSYFAKSLEFLLESQRVFDVRTMVLLVAGHRLPPELTDQVSGYLLYHKGLPLTDVKTKHDWRSNVARASTTTAASSGTSKACMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDJ9</accession>
    <name>A0A6A6QDJ9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_470553</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1230"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1277"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1344"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="238"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="474"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="796"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2490352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1401" mass="156373" checksum="6AD888265ABAE129" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDR4</accession>
    <name>A0A6A6QDR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_543543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFQ5"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="564"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2490830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113690" checksum="AE0E6CC7B363B908" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH17</accession>
    <name>A0A6A6QH17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_118461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH17"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025533783" description="Chitin-binding type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="144" mass="15405" checksum="6704865982B6B270" modified="2020-06-17" version="1">MRIQLSLVAALCCAFPAVFAHVDGNGHLHERSTSLKVSKDGRCGGYTGQTCDGSAFGNCCNKDGWCGKSVSCCGTGCQTKFGTCKSEISTDGKCGKNGKSCLGSKFGDCCNKDGYWLTQRLKSRLLLLSRPILHLRSHLPPRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH25</accession>
    <name>A0A6A6QH25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH25"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="515" mass="56899" checksum="9C4EDF6ED6507A5E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHF9</accession>
    <name>A0A6A6QHF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_124394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHF9"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025612778" description="pectin lyase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="99"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2491641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="386" mass="39573" checksum="BC0CFC5D0ADF4510" modified="2020-06-17" version="1">MPGMSILSLLSLALLAGRSVAVGVSGTPEGFAASTTGGGSATPQYPADIAELKTWLTDSTARVIVLNKEYNFIGSEGSVTETGCRPASNKCPGDGGQDAINHADWCTNGNAGTGATSISVTYDKAGVSSIDVGSNKSIIGIGSSGVIRGKGLRIANGAKNVIIQNIHITELNPQYIWGGDAITIAGADLVWIDHVKISLIGRQFVVLGTTASNRVSITNNEFDGSTSWSATCDNHHYWALYFTGSNDLVTLKGNYIHHTSGRSPKVGGNSVIHAVNNYWYANSGHAFDVASGGYVVAEGNVFQNVVSPLLSGSAGSVFSSPDTTTNKACSTYLGHVCQLNAFGSSGTLTGSVTSFFSDFSGKTVATAAANTGVASSVKGNAGVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHR7</accession>
    <name>A0A6A6QHR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_124365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1731" mass="192930" checksum="D8A7B5D428AA1B3B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHT3</accession>
    <name>A0A6A6QHT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_594726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHT3"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="55"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="420" mass="44300" checksum="788DEE131C70574A" modified="2020-06-17" version="1">MAPICFILSDVRIFTGTDTIESGYVVVKDGLISAVSAGPAPADADVQIISKPGYTVLPGFIDAHMHADKGQELALYQSLAFGVTTVMDMHNETVNVHKLKKLAAEKKDKAADFKAAGVAATIDGGWPMPVVTAHDKSEETAAEIATWPKLASVADAEAYVAHNLSPAGGADYTKLMHESGAALGQPFPKPSLDIQQAVITATHAAGHVAVAHCLGRADTLEVLSLGINGLAHTFLDEPVSEEIVDGYKKAGAWCSPTLSLLGSLTKEGAAVAERFANDVRVKGKLTEKGHANLCRCMGFSREGATVENAYGTVRRLKAEGVPIIVGSDSAGPGLGTAWGVTFHHELYLLVNECGFSPREALHAGTALTAKLFGWNDRGRIAQGLKADLVMVEGNPLDDINATLSIRGVWRDGIQAKDFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QIF1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_130853</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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            <begin position="10"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIK4</accession>
    <name>A0A6A6QIK4_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">BU16DRAFT_542174</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR35179:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="12"/>
            <end position="31"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="39483" checksum="9504940C2A9A3108" modified="2020-06-17" version="1">MGKVIESEMDVPSIAMGFSLGFFVLTSMKAARQTVAIYKRTQRVWNPYSWMIWAELVDNLVMTIYTWCYLRGNIKPSFGFFFGLICMWVIQTQLILQIIANRVGLVMVDKQKATRLKWALFILIGIVNVSVFCIWIPARMKVSETFIHINNVWDRAEKIIFLFIDLALNGYFLWLVRSKLIQRGLTKYKPLFNFNASIIVASLAMDVLIVGMMSLPNTFIYVQFHPLAYLVKLNIELSMADLISKVVRGSDRTDAFHSDSRSGGTTELTSHGKSKHRSEHPLGNPTTSHAFASKGNKRDDDSISLEEQTGIIKTVATTIVTEGAHDREGDKDDGRSTSSSTAELHHYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QJM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
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            <begin position="206"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
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        </location>
    </feature>
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        <location>
            <begin position="385"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="938" mass="106590" checksum="ABEBDF1F1F4ACFCA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK69</accession>
    <name>A0A6A6QK69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK69"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="401" mass="42790" checksum="81BD16C71FE916DD" modified="2020-06-17" version="1">MSEQNAQHPSTQTEGSPLTPDELRVLAELLRRAVAHGQDPRLEGDVGNFDGPPDLPLTDSRAGRSRSPVEDPGAPDNGNAVYKPQEDGADGSETRAASIPEASAELDADDVPHIAEEAFGTQEIGASGQAQHGHDIEDTSFINVSPEETPVARDVDEASPSANTQAAVTGNQGVADEEDHVHDSEVDDLHDSEEDDLYDSEEDVQSTTSAAWDDATEERATDDSENIDAVPSPTPPVAEYFRLIRLGMGEEEAKDEVIKHQLIDVSAAEQEDLKEALRYSLDEAIGTEIRRYHAAQLDVKNQREGGGSNGEGTSSGFDGDSAGFESTVGAEEPVRRSGDVSLEANEVNEDNGDGEQGEARTSENRRDGGTDEISSEIDVPGDAADEVEREMAAMAAMDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK92</accession>
    <name>A0A6A6QK92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_89365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK92"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="277" mass="30617" checksum="A1BC677BD3D963F8" modified="2020-06-17" version="1">MLSQLYISMQNHGTDSQGISFPAHINSRRTYQKSYLPQTSNTAAMLIIGPPPNTITPEYSLPTIMSEDPLHTAASEWPFATAMSARSSLNTSNRSFASAQENLLPPGLQRSANSSQNTLKGTTESLCTSISQATLASDAHSEVNAASHALSQVTTASDASFGTQLMNTLRPSALLSQYTDMACNDFVVSPDCRPPLRCCEKSQSIIKSLTGPWKALRNKMDDRKFKKIKEKVKRDNVRNKRKTDPWRDMRVPRRRLTILGRRSSGSRITRINGVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK93</accession>
    <name>A0A6A6QK93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_620757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK93"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="42453" checksum="32AF4D2BE7F0460F" modified="2020-06-17" version="1">MRLRIIQRTNWFKHRSIVLAIAAFFLVFSFSRLNPLHSSLPNVKPSLPVLKPSLPVPPHGSKMKENVRIAKASMLYGAQNEILEGAMETHRLHNVNYGYEMHVLRQSITNGYWNKFAYLFTLVAKELTKPEEERIEWIMYFDANNIFLNPLIPLSIFLPPPDFAHVNMLVSNHPYGLSSSVFFLRVCPWSLKLLVAVMGLPMFDSGIDSVIAMDLAWDRASLAKVLDRPEFRSKVLYQPASWYNSAKSINGSSITIPGLLLLQFHISLEGNRWSSMKDVLDELATDATKFAMKLEDTAYPAAIEDYWNRVKSARLRLREAEQGLEFMGEDVSAELKKAIESFRKGFAVTVADEDELNQAVGRLKDAMWSHSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKS5</accession>
    <name>A0A6A6QKS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_583909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKS5"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="344" mass="39433" checksum="73949612B38E6EF9" modified="2020-06-17" version="1">MTTPTIPAATRVLTTAELLENILHHLPPASLLRAQGCCRLFHALISTSPLLQSDLFFRYTAQSSKSNSTTNSFALNPILVSAFPEWFQSALDESKHQPSPYQVYRENLPPGIDGRDVLKESEHIFHRLPWTTRREEFKSKEASWRRMLISNPPIRKIEFRKENSSETGTSFEVAMVTIPREGENCESDASLKTVNGPLAYSTSEAEAVLRGERDVEEDMATRDERWRRYVEMRSALYEPQGEEEVLQDEGLRMGVLYDYVEEAVGSMKVKRPYSVTFEFEVWKRGRLSPSLLGRDDASNETILRVTLSYFHGCLYEEDVPMHDFHSDGFQKVVVGPWFRRRGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLN4</accession>
    <name>A0A6A6QLN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_620298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MU004193">
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    <sequence length="467" mass="49743" checksum="DE76EEBF8D22B875" modified="2020-06-17" version="1">MAFLRKAAHALLALSLVGRTVTPVAAITLDPTNSDSIKSAAKIVAKDLMGYYATGSTGAVLSGIPGLLTYPPYYWWEAGAMFGQMVEYWYYTGDDTYNDIVSAGMQNQVGVARDFMPANQSKDEGNDDQLFWAFAVMSATEVGFPNPAADKPQWLALAQSVFNQLTTRWDTSLCAGGLPWQIYTWNQGYNYKNTAANGGLFQLGARLAKYTGNQTYADWANKAYDWLASSPLITADLQVYDGSNSLQNCTDADRLQWSYNYGIMIGGAAYMYNYTNGSTIWQTRLTGFLTHAESVFFPTAYGSQTMVEVACEVTQKCDVDQWSFKAYLARWMAISAQIAPFTAAKITPLLQASAKAAATQCNGGTDGTECGSRWFQDTCDGNVGVGQSMSALSVIQANLIASAKAPLSADTGGTSKGNPAAGTGGNEGSAKTGLSEITTADKAGAGIVTTLALIAVLGGGWFLVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM09</accession>
    <name>A0A6A6QM09_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QM72_9PEZI</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493362.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="628" mass="69126" checksum="9700A22D45B811B0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMF2</accession>
    <name>A0A6A6QMF2_9PEZI</name>
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            <fullName evidence="3">Thioredoxin</fullName>
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    </protein>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
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    </dbReference>
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        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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    <accession>A0A6A6QMH1</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <sequence length="738" mass="80866" checksum="5081D4E68D1BC68F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="748" mass="84416" checksum="C3E507032CEE3AFC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="37471" checksum="3FDEBB13F1796639" modified="2020-06-17" version="1">MNNPYTVNSVCKKYLWRPFLCIGLLSPEPPFYLSEVAAFFTHSLIIKSNTCPPFAVAVCSSLIRHSPTGVDLQAAHYQRAHRYRPLIANRKATSGQSERAICAMPVRHTNDEHSANASMQLREQERAEIRSRVKQEPMDATIKLEEEMEMQHRAQGQDEARGPIKPEPTDTANKFEEDFEFGEDFEFGDDSELKEEFAMHRRARGTAEMGGRVKQEPRDPAVKIGEAESQHRTREQAKTRRRVKKGPRDTRTRSEKNAARNAQSEQLQQRRRQLGKNIGFSHRKRQRAKNDEACGRISSAERARIVVAEEEKTERWQEELDATRW</sequence>
</entry>
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    <name>A0A6A6QNS5_9PEZI</name>
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            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494158.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="16877" checksum="31E1DA5CAE3DCB3B" modified="2020-06-17" version="1">MAKPSTAARPQGAPMSRWTTGWINNPVQRYFNGSGSQSTPTPTPAAGNAFGRGGLGLGKGKAMKRHRRVLKDNIHGITKSDIRRLARRGGVKRISADVYEETRLALRARLEKLLKEMTAVVEVCGRKTVCVSDVIFVLKRLGSPIYGFGEANRR</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="168" mass="18928" checksum="8AB57228D8869F53" modified="2020-06-17" version="1" fragment="single">TYSFQETTFARRLTRATVERGFHLLSTSSLHPAAVNHVFKLSLPYITRDQMLARFRAILTKSNSDTLDCWQTPFIHLGGAGTHYPRRDANGSTSPPPNSWNVRSIGPMKKLVLENSVDSTLNQVIDVDLRGFEGEWFDAHDVEGYLEELGVRIDPQASFAEAYVDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QNZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_540490</name>
    </gene>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="31341" checksum="E4DE614FFC0E8FB1" modified="2020-06-17" version="1">MAQKAEFIKIPPAPSGLPQTTPTEPERRLPSSDISISEATVEDLPRIVEGFYASFPPQFWERKEPLALRPPTEAIRHERFIRRLLPTFSNPNVHWIIAKHVPTNAIMGVAGWTAPGAPIHNFFRRSAVDFFGWRSQYACSDAEYDALWSVLNKEAWEDQFTKDDETRKQVLGDEPHWYLAPLFTFPEWQGRGVGKLLLSWAIEQADKTEPVTPLYLESTPTARAVYMHCGFVPQGDWNFVRRGPAVVRGLEAEEGRGEGKAASVSVDAVAVEKEAAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPP1</accession>
    <name>A0A6A6QPP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF788 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_529144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="179" mass="20212" checksum="381030A430F7605A" modified="2020-06-17" version="1">MAQKAAKTLAARNTQILNRTLSISLAVHAFYLLLRLILFRGSFTRKSLITYLLLWLPAAFIQFQFERIGRPTYASAGAGERKELKKSGDDLEAKGLTEWMWDVLYWTYGCTILVAVLGDWAWWWWAIIPLYSGWLAYTTFMGAKGGMAGMTDSAGVPQGGASKRSQKLEKRGGQKMQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ01</accession>
    <name>A0A6A6QQ01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_527552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ01"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="283"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="50381" checksum="A58F8B44BE8DF846" modified="2020-06-17" version="1">MSQTELQTITASHHNSRSHPSTPNIQPQNEIRPISHTSLQSNAGTHETPRRLSDDERLQTTAETPDSTNVTTAIPDGGPGWTIVAACSTMTFWFNGYSTAWGVLQTALLSSSLSATTPATISFVGTLSIGICVAFGLFNVRVMRLFGARNTALFGMLLFGAGLIAASFTTTNLGGMFGTAGVLSGVGSVFLYGICNILPTQYFSTKLGLANGLVKAGGGLGGTVLSLAGDALIRHVGIAWTFRILGLLMLATGLPAAWLVKEREGARLRRSQFVEWSMFRSVPFTAVFIAASLATFALFVPPFFLPLFAKSIGLSSSTGAGLVAGFTLCTTTGRLVAGLLCDKIGPVNMFLLTMLLNAVSMLAIWPVSSTLAPLIIFAMLNGVANGAFFTTMPTVVGTMFGPGRAAVAMSMAITGWTGGYVMGAPIAGYLLQAAGGKVDGGVQGVEVYRPAIYYAGGVALASSFIVLIARLAMDRKIIKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQI5</accession>
    <name>A0A6A6QQI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_464082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQI5"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="176"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="176"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="51154" checksum="24200067568B8897" modified="2020-06-17" version="1">MDINESLQWSPGCDLPFSQLSQEPSNYQMTQQYTPDSSALYNYTAQRLPYRSSYNMTYSPTTTESSCPRTYTGLDLVGSAGNMNESYPPSAYLLEPQKPQDMLDISSHLTPGSMCNFEDDFEGHCPAMMKSEDSNYGHSRFDSDISMPNSISTPEPQVTSVDTCKSEPSHEDANVDKEQPYAQLIYRALMEQEGHTMVLRDIYNWFKRNTDKATDKETKGWQNSIRHNLSMNGAFEKVDQPVGDAMTREEAKKGFMWRLTDSAIREGVKSTTRYRSKLPNKRGCRSQNPAPQRQASGAKGGQAARKAARLRRSERLRDTRSVPMHKGDTYPPRPGPAYTPFDNFSPSDLAMGYPASPYYCHSEMDFGSPVKQEALPSPFGQNLDILSGQPYPDSPQDLCPDMRYLLPYSPEEPMFYGSGSESGSEPMTPLSSQDYCAMDTSMPQDPACHPEAGEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQV9</accession>
    <name>A0A6A6QQV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.1</ecNumber>
            <ecNumber evidence="13">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_550482</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="13"/>
    <dbReference type="EC" id="2.7.7.18" evidence="13"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQV9"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 13" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="30"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2494554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="30141" checksum="DFE3B7DBF889D09C" modified="2020-06-17" version="1">MTLANYKFPTDRLRKVLKDDTKTPIVLVSCGSFSPPTNLHLRMFEQASDYCEFQTQYELIGGFFSPVGDAYKKAGLVSAQHRINMTNIAVRESSDWIGVDAWEPLHKEYLPTVKVLDHFDFELNDVLGGIETQTGEKKRIHVALLAGADLIQTMSTPGLWAHEDLDRILGHYGAFILERSGTDIDDALTNLQQWSDNIRVIQQLIQNDVSSTKIRLFRKRGMSIRYLIPDKVVDYIYEHDLYLDDEKKSDKGKEKAVENSASVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR01</accession>
    <name>A0A6A6QR01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_589573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR01"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38182" checksum="6596B44971A220EE" modified="2020-06-17" version="1">MDGSLPQKKKHTTFQKPSNNLQPPTASMPYHEANGNGNRKTLTVHHSHPQNKKQTNQASHPKTINNAPSLSPMSYDQANRNRNHNPLHRLHSLSPRRLRTLFRSPSSHTPFPLLALPAELRNAIYTRALTPCITTPSLSIHSPRHPPSSPLFAVSRQIRHEALDVFYRTLYHLQRFHAPYPHRTFATFASHLGADRLKSLRQISVSLPAEGYRFDVDEVLATLPQLRSVEGRIDDMSVTACECKVRIRCRCGAPYYRDWRGVLGESEEFRVLRELVGKGMRVRVVWKTQERDEEGGWLVRDDMFRTTQHKRWLAEVEEWIGCERREVEGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR18</accession>
    <name>A0A6A6QR18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_562465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR18"/>
    <dbReference type="OrthoDB" id="5295996at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="26627" checksum="39DD3293436A63F9" modified="2020-06-17" version="1">MAASHYRGASLPETELSSWAASFAVALRFADGEYGPRGRHPHLAVFDTQALGNGVEVWHAPQLIGRGDHEYLAHGLISGEGYKAVAVADLEKAALRELRDGELAQEEVFAGSKSVARLFGEAFAMPVALALVTWVPRESWTGVVAILVEGAVAAGRWEEVERQGTLMRELTDYGHGRSVRQREFGERAEERERARVEEARVRESGDGDCEGIVEMEVKKKKSGKKGDDKGSGYDDAAKEYREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRK3</accession>
    <name>A0A6A6QRK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_461313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRK3"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="59132" checksum="E5BAFC81CA33C87E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRS1</accession>
    <name>A0A6A6QRS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">BU16DRAFT_513588</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRS1"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="396"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2493577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="512" mass="55172" checksum="A18338F86DCF32F7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSN7</accession>
    <name>A0A6A6QSN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_540457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSN7"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36750" checksum="294D8F025BE5888C" modified="2020-06-17" version="1">MVTKVQQLSKGDTEKNSPTEVPKDRPFAYHAYTIWLFARRDIASIVLPETCFGIFSALAGPLLTTNPHPTVFSIISRIPLVLLWNWLNVLLFGIANQRLPQSVLEDSINKSWRPLPAGRLTQTDARRLLLAVIPAVFAASWFLGGMPESVALMVLTWMYNDLGAADEHFHLRNLINACGFMCYSSGATTVAAGYRRYALNNTAYTWIGMIGAIVLTSLSLQDLPDVEGDAATGRLTLPLLHGDVVARWAIAVPVLMWSLVCPAFWGLSWPGWLVSVGFGALVAFRVLLKRGVVADKVSWKLWCLWTAVLYSLPLFKNGTALVECGLGLLKGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTK8</accession>
    <name>A0A6A6QTK8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="471" mass="52826" checksum="5362852EF1417C55" modified="2020-06-17" version="1">MASHEDRSPRGVVLFDEATSSNQILLNLEHVLPEELLILIMSSLDKKTLLSAARVSKRFGRIAQEPLFHTVDLHFGLQYIIPKARQLMRTLAYREDLRDKVKHLSFRIGNVWMNYQRGNHLLPRDAVSMIVDIVENLGWPVDDYGIEHILKGSKRALGPLLALLPSLESLSIRSERIDQSTVYDILFGSLQAAPDQIPAFSNLQALLIHQNYGLTSIIPSSNNEANLILSIPNLTRLDLSCIGFMELANIANTVPTKISNIKHLSIQTEKLVNLEGIRLLGKLLAHIGPLETFTFNDCMDTQSDCASSVWYSKLTEQLDASHESLERLTIKIHNRMDGWIPFKVYPITSLDHFTRLRNLDINAVALVGNPIRKRVMVLNWHSDSGVAMKTAGYGLLEKLPSSLETLVVRGTDYQLNTLWRGMKDEGIIQRRDDEPTGVEGCVYVVDGPHPKLANLRSIALYGPGTSIISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUH1</accession>
    <name>A0A6A6QUH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-alpha-acetyltransferas-like protein 15</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_526577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2496045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="581"/>
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        </location>
    </feature>
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        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="831" mass="95052" checksum="DF72584A60149561" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUR3</accession>
    <name>A0A6A6QUR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495882.1"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR38790">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="525" mass="58046" checksum="178C4B65F2F97F84" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUT5</accession>
    <name>A0A6A6QUT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_485826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUT5"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="20603" checksum="FAE5C9FC17AC40FA" modified="2020-06-17" version="1">MVRFGRKEVYLPNAVIALMKSEHLPATHAKFRVPLTFSKLDLRDYLYHAYGLRTDKIRSYVQQQRVQHDRPDATMPQQNKWFRPKAIKHMTVEMDKPFLWPEDPDNWEPWSKEIFNELQQNANDRDKPATRVKAAKMEGDTLATQARELLEGKKRWRRTPVDEEAVEVDSDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV95</accession>
    <name>A0A6A6QV95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phospholipid methyltransferase</fullName>
            <shortName evidence="18">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_526575</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 18">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="18"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV95"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 18 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 18 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="18">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2496044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="179" mass="19401" checksum="4B2A7B2CAC68EDF7" modified="2020-06-17" version="1">MTGLIDFSQPTLWAAAASIAFNPTFWNIAARQEYHNKAITKLFGGNSLHGCYALAVTIFSLGIIRDLIYHFTLQAQPVHPLLDNPTVKALSYGLFLSGNVLVLSSMWALGVTGTYLGDYFGILMDAPVTSFPFNVTDAPMYHGSTMSFLATALWAGKPAGVALTGLVWAAYTVARQFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVN7</accession>
    <name>A0A6A6QVN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1223-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_527890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVN7"/>
    <dbReference type="OrthoDB" id="3889015at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010634">
        <property type="entry name" value="DUF1223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057:SF1">
        <property type="entry name" value="LIPOPROTEIN LIPID ATTACHMENT SITE-LIKE PROTEIN, PUTATIVE (DUF1223)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06764">
        <property type="entry name" value="DUF1223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="259" mass="28260" checksum="9847E9B9E81BA205" modified="2020-06-17" version="1">MASIFRKIFRKKKNPPLKCEISLDGQPSLMESDPHHQHTAACFIDFAPLSVLELFQSQGCASCPPALPKIQAAAAKDPNLLLLTYDVTYFNSSTGWNDTFASNQWDARQKAYVKKWGRAGLFTPQVVADGIADGTGAEEGDVYGIVEAARGTKLAMEWHITLDVSEQGLRIDTDLQEAEVHDVLMIRYEPKLQTVKPGKGPNKGKKIKHVNQVAQVMKVGEWRGGNLDVVLPEMVGDGLETVAVVQQGPGGPIVVAQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVV4</accession>
    <name>A0A6A6QVV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_537710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVV4"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="401" mass="44793" checksum="1F13AF0DCA7E32EA" modified="2020-06-17" version="1">MRPPGSVIFAASAPFSFKWQVIGPVTALNVLAVVFVALRWYSRVSLTRKVGLDDYIITFALALSMLMTALIITALCFDRGNIDWHIDWHALEDITVLVYTNNALYQTAINLIKCSIVVQFLRIFTGPVPTRICHGILLLLLIAACWGVFGGIFLCIPIRKYWHPDFKGHCMNSHAYWYSAAGLNIMNDFIVWLFPMPFIKQLRLPTRQKIGLAIVFSLGGLVCIISVLRMLLVRIAVIKGDHIRTPLHRFHSLLSRPLLTSHLESGKEALLWSALEVNIAIVCACMMALKPLLVHLFPRLMEPKKPAPHSMMLPMLDTSFWGTTVTTSARRSSTCVEAPEGPWIKVDTETVVGEERVGLGTEDASVGCSVQGTGYRLGEERMGHPSEEWTMNSNSTERSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWA0</accession>
    <name>A0A6A6QWA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_339753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWA0"/>
    <dbReference type="OrthoDB" id="3525430at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025400077" description="Chitin-binding type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="434" mass="47785" checksum="AA1E3F019EBA225B" modified="2020-06-17" version="1">MLFIRLLLCAGVLGTAATSLVGRKGDQHRCGLAFGNKTCDAIFGRCCSSYGFCGKSDQHCLIDNGCQSGCIVIGTFSGLQSQYLHSTPTVTNATILLPWSWTVKPETEYAAKHPCPSVANILVTFAAINVISGALSTVFGHRLVVKKITFGLFGKRGGRSYIYMWIMPFAFQLGANALVANMIQRTTGYGHDFTIAQLMFFFAARPRVSWILVMLLSGISKRKLAKGQAEQDDQPLLDRSSSEFNAIPLDDVKDVSYSNVESLVEDHDSEHRQAQQRAEPVYEDDYYWRNAALSQYFAELALQAITLYYMSKTVVFAYKRGYYDPGSLPGPMGHSARIMYAGALFWLCAQLFVYLSAPTFVFILVKEGGGTMMVSKLMQMLGSVLVVTSWLASWLFWAGFVRLAGDLYCPPKLVEQGAIWSAFSSLGMIAGVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWK9</accession>
    <name>A0A6A6QWK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2og-Fe oxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_537978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="218"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="397" mass="43770" checksum="046663FE4C7B827D" modified="2020-06-17" version="1">MSETLTEPPPAGDDEYVFFHSGTTPTYRKITKTPGSFTTIPTIDISALNSPSPSLAARKDIAAQIHAACTVSGFFYLSNHGLPASLQASTFAAMTRFFALPHATKMTAHVQKNPAIRGFEPMFETRLDPRTQGDTKEAFTMGDCPLEPEQNYVSKTGAQPPSNITRPQNIWPEGEAWFRDAMYAYYAAVTPLAAKLIQIFALAFELPETAFDGLFKFPIWGMRALHYPPLPPTTTKGEEAAAVSLGAHSDFSWLTMVLQDEVSALEVLNKDGVWVDAPPVPGTFVCNVGQYLERQTAGRFVATVHRVRNKTGAERYSLPFFLTPDPGARLEVLECCVGEGEERGEAVDVGELYIRRVLPARPKHPTSIKYRDVPENYLKAQEPDLVKPIKFLNATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX78</accession>
    <name>A0A6A6QX78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_617087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX78"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000629">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="415"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="775"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1125" mass="124221" checksum="D08F1B7F508DB41F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX99</accession>
    <name>A0A6A6QX99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX99"/>
    <dbReference type="OrthoDB" id="3791931at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="495" mass="54326" checksum="CF0FF55AF469D928" modified="2020-06-17" version="1">MKLNKNDPLLRWNSSNPSRSAPADTGASENQQLAAPSGRQKTLRAGMRASHDADVMDEDGLFDPNCLDDIEDAGSVVDSNPFNTPSSNASSGPRSNAFSSSPSSTFGIHPAAAEYNPVGYLRGHMSPYEVALPSAQSRRPARPQRHQPAYGGYTPVLNYQYGPRTYSAYNQNTQAHRSTQLGGHTFTPSELRAMEGASFDAHPGSAFYPESPYGASSPFTATGQADAEGADFMTGFSWENRFGNPSARGTTPDYEADATPSGRSAGVMRNMFTPLSGHQRTPASLRQIARRSLATMSPILRGSVYDDGSESPDRNGIPIYRSTELSFDTLPTAMASVAPKQVWIPPQDDPTVPQTPEQMQDAVRKLMWAMMSDSIQEGDVKNPHANGILRDYNEDHLEITAWKILAEMLRLHEDGCYDDYVMSLRDRQWDFATRLNHVVTLFRRWKNAASDAIKGHHIATFVAAPCEHDRRKRSNAKGNANKAAAIRLAKTLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXK6</accession>
    <name>A0A6A6QXK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_356406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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</entry>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <source>
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    </evidence>
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</entry>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1A6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="176" mass="19273" checksum="A79F1D56795AB974" modified="2020-06-17" version="1">MSIGIELKRVAPTWYASPFFHGRSMMLPSTALVVDLGQGLGRLARLTCRPHPCLAIFAGTKFRESVRRDGQGLCGSCSPFSTNFLHRAPAITTPRCWSRPLSTPSRMCSCIVSTATAGLVWTALTMPAQLNIPCTASRRVREQSGPLFPGFTTMREQAEVTAVRLCAWLWRSEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Z2</accession>
    <name>A0A6A6R1Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_615734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1Z2"/>
    <dbReference type="OrthoDB" id="3787398at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="333" mass="38575" checksum="19411DA5EB41B14E" modified="2020-06-17" version="1">MAEPFAEALRKATTNCESGWIDERHDIPTIAPEDRIRFLSAELSNRINDKERLQDDRLDRRALYTGVMRLFDEKEILVERWPAKARLILTQVADSASTQPFETHYENLTRQRRRNAVWASLLCFLVYAWENEEACLREMGLELSDEHADDIMDIQQALLMEGFPVTMEKKHGMVEAAIENFFHGLVREERPSGRGNPLLWWITIPVRSAVEEGGDDYISRGVFRENVLPMDLDVRTRLEAIVHYAKVLELYVAFGKWQPNPERYLSVEKDLNAVDCTWIGQHGGPRPERALEDETKYDSEAWKDVLSHLEKEFDIAMGNCRTTTVPEIAKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Z8</accession>
    <name>A0A6A6R1Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_481068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1Z8"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="507" mass="57513" checksum="AD5D7538C24F9FC3" modified="2020-06-17" version="1" fragment="single">MAGAELALGIIATVDLAFRYGKLLVDTYKTFKGAEADVEERVLSVEAHWYRTRQQVEFLQKIWSTLDDEFQNIQIRTLRILVGKLEAAVAQIERVQKKKDKDGETQNKTGIRKLKYVLIKESLGKAIQEFESWQKVFNPSWFLIMKVASPVIDQELEDDRTEVGSMKTARGLRDSLKKEPQIATRIFLPENGLVLANRTQIPFSTAELIQRTPTSKLSILDSVAGDPDVNINILNKDVRDLARKLSRADALTFGLLECKGVVKVVEPTKKKIVSFDFVFNIPEGMQNPKSLRAILLKADQDLSLSARFKVAQQLATSVSFIHTYGFVHKSIRPETVLIFGSSKSTLAASFLLGFERFRMAEGRTMRFGDCVWYKDIYRHPRRQGLKPEDEYIMQHDIYSLGVCLLEIGLWDTFVVYQDEETTDPAPSRLLSVLQDQEEDEVKKATLVKDALVELATQMLPSRMGDKYTEIVVTCLTCLDETNADFGDDSEFEDEDGVTIGVRYIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R237</accession>
    <name>A0A6A6R237_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_331674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R237"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="166" mass="17527" checksum="D0FF07EA157DEC7A" modified="2020-06-17" version="1">MGRYGNGNSRLLQDLSSVSASKPGVANEVVLQWVLGVLGALDTVRQAGAEVAEQRRRRAQETALGLIVSRCGDCGGGSLHSGSGKAGSKSALGRRAGMGWSGWSGWWRDGWKDAESAQRMVRPLALSVEEACRACLHTAGNALGEMMSAHAEPMLPKRHGTTSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R245</accession>
    <name>A0A6A6R245_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_548896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R245"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2W0"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="260" mass="29870" checksum="4E486A465116950A" modified="2020-06-17" version="1">MPQNEYMERHAKQHGKRFDYEERKRKRIAREQHKGSENAQNFRGLRAKLYQQKRRKEKIQMKKTIRAHEERNVKSSEAAEPSSTPLPQYLLDRSSEKNAKALSSAIKQKRNEKAARFSVPLPKVKGISEEEMFSVVKTGKKTQKKGWKRVVTKPTFVGPDFTRRPVKYERFIRPMGLRYKKANVTHTELAVTVQLPIISVKKNPQNPMYTQLGVLTRGTIIEVNVSDLGLVTAGGKVVWGRYAQITNNPENDGCINALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3K3</accession>
    <name>A0A6A6R3K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_308478</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3K3"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="134"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="377" mass="41836" checksum="66D1E2484BEE9F79" modified="2020-06-17" version="1">MPADDYDARALALPIDEPPPSPAWTRRSASFRRNDSPYSVSTRPPTFLAKVRKNGEKLHRRAMQTYNNLSPVKKVLVSVGGVVVIVLGILFLVYNERIFGVLAPWAKKWRNVRAGWLILWSMIFIVSFPPLIGYSSLLTIAGFVYGFPNGWFIAASATIVGSTVSFILSRSLLKDWVHRLIANDKRFAALALTLKHDGLKLLIMIRLCPLPYSLSNGAIATFPTVHWASFAAATTIVSPKLMLHIFIGAQLDKIAESGGKMDPKTKAISYISILIGAVAGVVTGWFMYSKTKQRAAELEAEERAGVRRASVEDLENEYADDPDALEAAETLREEDDDISLRPAEYHDDLSDTDLDDDPDDVFMRGHEDEEEAVVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3N2</accession>
    <name>A0A6A6R3N2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_455608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3N2"/>
    <dbReference type="OrthoDB" id="4716584at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="626" mass="69387" checksum="1242DCCB482D1E3E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3Z5</accession>
    <name>A0A6A6R3Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_603553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3Z5"/>
    <dbReference type="OrthoDB" id="3922703at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025675315" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="19988" checksum="C82EF6EE7F1977E2" modified="2020-06-17" version="1">MQLLYLLLSSLLILPTLGNPIVPRSNTITAPKSETWHISAFTAHFMGDSSGLPGGAWPPNSAFNTTLSFTLKFPDNTTSSCAATFQEPGTPAAYTVCERRADGSVVELKVKKAHAAKTKWALYNFELSVVKEGGVRAPMKGKRHISSNNAATDEDSYLTCLTYAPLTGVQCQLGGVVGKSGPIEVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R476</accession>
    <name>A0A6A6R476_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative beta-Ig-H3/fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_524009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R476"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="138"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="279"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="475" mass="52671" checksum="BD1940AA20A36457" modified="2020-06-17" version="1">MKLSNLLPFATLGASLVIVDEKVFQEIEVESHRVKDPVAKLGRPCHDKLLEWKSEAESVFKTSKNYLDEALAKVIDVSETSYDKIYSTGYDVQAWLEGSPFAQESDDDESDHPHHPPPHHGPPHHRKPHHPPHHHKPNLTVYELIAKSKYTTKLAKIISEDEELVKVLNGTKANYTIFAPTDKAFEKIPDHGKKPSKEFIKDLLLYHVSPEFYPAGRVLHSYTIPTLYEPSTLGHPQRLVVSTGLGGIKINFYSKIVAVNIFGTNGVIHGVDSLIIPPPKVVDIVGLFPGEFSTLTLGLTKTGLLSALNDTSTHTGGIFFAPGNFAFRKLGPKINAFLFSKFGTPYLKALLEYHVVANQTLYSDAYFDATADSVEVETPRYAHYDFPTALKEKSLAVDVTRFGPFVTIKINGFSKVTLANGVAKDGVIHIVSNVLIPPKKESGSATPSFWNGEELTVEELKDRLEPFVKDETPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4D1</accession>
    <name>A0A6A6R4D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">APH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_548437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4D1"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="380" mass="42431" checksum="4891C8A2367AB915" modified="2020-06-17" version="1">MNPTPKPTTRHDLPDVALGAYLLSHLPGLTLPIVSTKIGYGQSNPTYFVDDSAGERYILRKKPAGTIISPVAHQVDREFRVLEALGKVDGFPVPKVFCLCMDNEVIGTAFFVMEFVRGRIITDPDLSTLSKGDRRAAWFSVVETLAWLHSIDPDAIGLSGFGKKTDFYKRHCNTFSRIEAQQAKVLDIKTKKPLGRAHDAFDEIIDFIRKRLPGEKTSIVHGDYKFDNLVLHPTEPRLIAILDLELSTIGHPLMDAVYVVGPYWNRADGAHAGPTRDDMGGPVYEPANLEAGGMPRMDELLDKYAEVAGWDPREDRWEVAKVFHLMRGGTISHGIQARTISGQASSEFSHIYFENTRRSLDSALRKVRDIKMKEGEKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5A1</accession>
    <name>A0A6A6R5A1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_534561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2499918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5A1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="45334" checksum="61835047F129A222" modified="2020-06-17" version="1">MRNLLAIYYKYKIFLHCAEARRVLDQLPKEEQLAATSILTDAQNPSHPQHGAWQEFVQAGYWDALREESLLIKLDVSKDDPGFRALFDKAVAAGHVSESDVEAFCKRVNDNPNASLKLRIDKNTGEVWYNQKIDIYATDTAVKFFNKHKNEEAEKQFNSLAPEDQRLFTQLSIDRNKNKEDPKHQAFGEEFLADPRIAAWCTQRIANTVGMPITDLGTGKLVIGYPSNDADENASKSWEPQKELAEETCRSINANPNATFKIELVGDKVEFHHKSWDPVTNPGPKRKELHEAPPGWQPKTYEPRRCPTCHRTRLDAHCDFLECTGCFNEEYCSVNCAMVDWSRHKGDCRKRCGGCGKAGEVQSCAACVVTKYCSRDCQKADWKRHRAECNRMKNGGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5E2</accession>
    <name>A0A6A6R5E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_278412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5E2"/>
    <dbReference type="OrthoDB" id="10485590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="211" mass="24831" checksum="896ACADCAE859CCF" modified="2020-06-17" version="1">MAPFQDTRPPLDPYEQQLPLRVDNPYPVKQEPWPPYRHRHIPRSSSSSAIRSTTPSTPPSRPRSRHFSFTPSSFDDDRYSRAPRRPGDLRSRYRNSLDQGRVGSPANSQYRQDGVPTSRFEPRNVYPSRPQNEEPKGAGQRLRTPPYHRFEQYPNFRPPPPPIDRCTRPDLDFPKPSTSSELERTRDTSAQSNERLMIEGRDWKRPRRNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5F7</accession>
    <name>A0A6A6R5F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_454250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5F7"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="79" mass="9398" checksum="B87608DEF844B22D" modified="2020-06-17" version="1">MAKLSGLQRDVLALYRQCLRAARAKPAETRKNFEDFTRKEFREHIHLNKKDFSTIEYMLRRGNRQLEIYADPGITNISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6M9</accession>
    <name>A0A6A6R6M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_601686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6M9"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="352" mass="39166" checksum="6FFE57CE8AC33383" modified="2020-06-17" version="1">MLDRNGVDPNHLNLTTTNSTLIAMQRKYCKLGECPISWATISYLPNLGGNVVYLACFFVLLGIQMFFGIKHKTWTFLGSMIMGLLLEIIGYIGRIMLHNNPFIMNNFLVYLICLTIGPAFFSGCIYLCLGRIITVVGPENSRLQPRTYAKIFIGCDLFALVLQAVGGALASTAKDHAGSQQGTNVMIAGLVSQVISMVLFMALWLDFTIRVRKAKAMGSLGRSQPPLYNTLRNSRIFTGFQLSLVIATVLIFIRCIYRVAELAGGFDSAIANSEVSFMIFEGPMIIIAVALITWFHPGRVFRQLWVPAGKGDRLVTKGMKPMHSNNGSDRYINYRPTSYLYLKVPKTVIHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6Z3</accession>
    <name>A0A6A6R6Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_578302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6Z3"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="223" mass="22772" checksum="E7095DE44AB12C76" modified="2020-06-17" version="1">MPPKKSTAAAPKKAAAAAPAHGSYQDMVKEAILNLKERNGSSRQAIKKYIQANNNLGGTTEAMFTSHLNRAILSGEKSNDFARPKGPSGPVKLAKKEAKPAAAKPAAKPAAAKKVAAKPAAKKASATKAPAKKPAAKKVAAKKAPAAKKVAAKPKANAGRPRKTAQPAPAVVEPKTILSKTKSGRVTKTKAPAVTKPAKKAATKKAPAKKATPKKATPKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7K4</accession>
    <name>A0A6A6R7K4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">LYR motif-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_453435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7K4"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10244" checksum="0E6A5F6D8F217615" modified="2020-06-17" version="1">MTLNSSLRHEVIRIYKELLYLGREYPLGFDYFRPRLHKAFASQAGIKDEEQIRQGIKRAEFVKKGESSSTVVACKCRADRQRPEIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9Z1</accession>
    <name>A0A6A6R9Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_613116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2501182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025376154" evidence="3">
        <location>
            <begin position="28"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="119"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="584" mass="63805" checksum="36D6FCB530AEC26F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA80</accession>
    <name>A0A6A6RA80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_577822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA80"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="119" mass="13803" checksum="97FA59BE9343A81A" modified="2020-06-17" version="1">MRPPTLNLALLSLFESLIFLFITMLGLSLSIEFVKLFRAAAVFSLRDIVSATRSDNGNAFMVWSLGNLFERYLFAWQNRVLDWQATLMSQFWWVVGGFFVANVIRRVPVLSRHRLEGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAM3</accession>
    <name>A0A6A6RAM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_210597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
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        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="78"/>
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        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="551" mass="61455" checksum="38A821C23D6A1255" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAQ2</accession>
    <name>A0A6A6RAQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="16528" checksum="B6A006A2E67C06E3" modified="2020-06-17" version="1" fragment="single">GWYQGGRRLPKVKPHYAFVWPKDGKRGTTSGRWKDILQNKGPDIHVTISADKGDHLYNRQRRPRWARWNDVDPRGPDGALPGMPWTQKHRKPGVRYNFRARKYCYPKDNAWMDVRWPMEPNTRLGPSAFKDMNAQWWQN</sequence>
</entry>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502065.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
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    <dbReference type="PANTHER" id="PTHR15157">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="638" mass="70984" checksum="19569A393D62630E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC46</accession>
    <name>A0A6A6RC46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC46"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="303" mass="34133" checksum="66F01A74B1C1CFCA" modified="2020-06-17" version="1">MAVNRIYNRLVRFLDPPRPAMFEDLPAEIVLKALELLFLLKMATYVGPGENANDISLDLESPRPLILRQLVKALPYLQIDSTTRSLLLDSVVALTPPKKSLAALQEALDLQPFVIHGTVCADTQDTPTVPITPRSKVLDIFASAQYDKDRWTGEPLLQLQSDAHRCTLRSEAKKRRGNLDDATRRRLRRRAKQVDIDFAGKRRAQIQWRAARLGGFGAVDATVGLPPALRVGTQMPKERGANCISWSAFGGVSPVWADITVNRFRTCELNPFDNELNILIMNEVTTEWCKVYLMKLVKRKCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCS9</accession>
    <name>A0A6A6RCS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_448215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCS9"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="476" mass="53273" checksum="04CB70AE453B7B38" modified="2020-06-17" version="1">MLRPPQKPLVAIIGATGTGKSELAVEIARRFNGEIINGDAMQLYHGLPVITNKIPEVEQKGIPHHLLGCIGLEQETWTVGKFVDKALGVIEEIRSRNQLPVLVGGTHYYTQSLLFHDILADDTALSSSNNQHFPILDEPTDVILTKLQEVDPIMAERWHPTDRQKIRRSLELFLKTGKPASKIYEEQAIRRQAVVDADNPADDGEREGKSGGLTMTMRFPALIFWIHASREALCKRLDGRILKMLENGLLEEVSTLSIFREGQEAKGFAVDQTRGIWVSIGYKEFLAYRTALASGAADAQELARLKEAAVAHTQAATRQYANRQVKWIRIKLMNALAGAGQTTNIFLLDGTDLAIWDERVISPAMGITEKFLNGDSLPPPVDVSDIATELLKPKSEDLSQRRDLWGKKTCEVCGIVGTTVNDWEQHIKSRAHRRAVAIKEKKKVKEQMRERGLKMDAQKEVIDVLENHLDLFAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD12</accession>
    <name>A0A6A6RD12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD12"/>
    <dbReference type="OrthoDB" id="3219467at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31809" checksum="85045069BEB1D715" modified="2020-06-17" version="1">MWLERLLPTTVPVRRSTGWVAMNDPGSGGPVKGAIWFKIGTFGQINIDFENAAMAKKNYYGVYTSDDGGRCATSISGTTRSTATTRRETTRSENLAAIIFARKLDLQWWNSRTSFTAHTKEKMLDNYGSRRLTARTRAGPYNTYDASSWSGDRLVRDESIMSESSTAVVWNDKLHCFFQRPNQNGELNYVVCDGNSCTASQKIPSVGMSASPTAAVVDGKIRIFHYGWGSNGQLWSLLFGDTPENTPVVGVGLSYSPAVAAEDVGNTKLKLHTTFCVQHLWSPPRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE27</accession>
    <name>A0A6A6RE27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_556191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE27"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="182" mass="20536" checksum="18AEA63F54BA7CEA" modified="2020-06-17" version="1">MATEDDTIFHDIESQESKDPSPPLVSDKGPIYHSHPTMLELSGHPILTDFGDMRLVEPMSTDWAMPDISRAPEVLLKLPWTDPVDIWSVGVMTLELLEGKNLFDPVDRENHQYVLPLALAQYIGYLGPPSLEMAKRSPLFSQYFDDQVRAQSADLLTDEWLMKPNDIMGLAFPSQEEPEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF33</accession>
    <name>A0A6A6RF33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenine deaminase</fullName>
            <shortName evidence="4">ADE</shortName>
            <ecNumber evidence="4">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Adenine aminohydrolase</fullName>
            <shortName evidence="4">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AAH1</name>
        <name evidence="6" type="ORF">BU16DRAFT_521646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="4"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF33"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2503016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="337" mass="37784" checksum="A32E0AA410D36B2F" modified="2020-06-17" version="1">MTSKASFIAGLPKAELHLHIEGTLEPALVRQLASRNKIPIPDAISSLTSTSSGYTFNDLTSFLAVYYPNMAVLLTSTDFFDMAYAYLTKAHSQNVIHAEIFFDPQAHTSRGVPFSTVISGLRQAIIKAERELGMSASLIMCFLRDMSPEFAMATLTEALPYKDYIIGVGLDSDERQNPPAKFAAVFARARQEGWLVTCHCDIDQQDSIKHIRQVLNEIQVDRIDHGTNIVEDASLVELVKEKRIGLTCCPVSNSVVTKDFKGEEILQLLRAGVKVTVNSDDPAYFRGYMNENLMKTMDETDITREEIVQLQRNAFEVAWISERKRERFLGLLDSHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFJ2</accession>
    <name>A0A6A6RFJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_499561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFJ2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8D4"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="365" mass="40798" checksum="710A9BF751163051" modified="2020-06-17" version="1">MADQFETFKLGNFKLKSGGEIPDAYIAYKTFGDPSLPAIIYPSWYSGAISDNFWLIGEDKTLNPKKYFIIVTALFGNGQSSSPSNMPSLRPFPDVLFYDNVKAQHTLVTKHLGITHARAVLGWSMGAGQTYQWATQYPEFMDIVVPFCGSAKTSLHNQVFLEGVKSGLFAAKGTSSAGISKGEIRATGAEYRGFTEEEKNNGLKALGRVYAGWGFSQAFYREKLYEKVLGFKDLEDFMVNFWEKWACSKDPENMLVMAHTWQAGDCSQQEPYNGDFAEAMQGIKAKALILPGQTDLYFPPEDSEIEVANMKPGIGELQIWPSIWGHWAGGPGDSKEDLKWLDDKLRYFFEKHKDTLSEKVGSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8V5</accession>
    <name>A0A6A6Q8V5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_473388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004201">
        <property type="protein sequence ID" value="KAF2488722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8V5"/>
    <dbReference type="OrthoDB" id="3699854at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="55" mass="6563" checksum="5150D83827BD6DD3" modified="2020-06-17" version="1">MHHHPTNQERALNLSILKLSGPVKLSRRFHAWWCPSVNFFKFQPCDHTPPRTQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8Z1</accession>
    <name>A0A6A6Q8Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8Z1"/>
    <dbReference type="OrthoDB" id="3856336at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="112" mass="12366" checksum="C442D55D64ACC148" modified="2020-06-17" version="1">MPAPTVLSAFMSLTPTEPVLVFASNTDAETFQSRCRQGRILSAQSGRWVYLPLPAGLQRVRTARGGDVAFEFDSNRNAAAWNLSIGEVGKIYASSKEKPRFDQGVYLGRVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA12</accession>
    <name>A0A6A6QA12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_586311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA12"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30138" checksum="31CFA2EB75C92411" modified="2020-06-17" version="1">MYLNGSRGGNGDDGSITSCGNQQYCCQSDVNDGSCDCDTGKGIFSLADGVAQTIIGVSGLEATTVPPVSRASSRPTASTTATSVTATSSAKSATTLASSTQRSSSRASSTATATESSPSQTSSAATPSLVHTTRFKVGLGVGLGVGIFALILLGIFIWWWFTRRGNRSPHPNPSPYDTNSDTHPDDIRLPNISHPATAPNPNPYDGEGFRGGSYPPTITTPPPQARPGQSRDMLGTAPTNNPYESTYSFSSRGGDSVRNQYPNPYAPPQRLERVGETSVPQEGLPRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAQ0</accession>
    <name>A0A6A6QAQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_531541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAQ0"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
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    </dbReference>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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    </evidence>
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</entry>
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            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">BU16DRAFT_472553</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC35</accession>
    <name>A0A6A6QC35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2489213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="342" mass="39130" checksum="3B8D2B2DB3B03367" modified="2020-06-17" version="1">MSTLSKSNFADARYGKPAIVCSVHDVTNMGARTASRCLCHVVSAFRWLNGPVLAVWEAFESNFLRLDLSGPQKDRMYHIFLTMITKRPAEPCVREALFSALDRWRAVQTHERFGPAATLLRGLLCKVFLHRKLDVPVAKIEQAAYVVEAAELPHWAAITKKMPSGIFEGFPEDRLVIVPVILITFADHDSNTVVFAPLGPHLGLPAVFQWSDFVKVVSKTAQKPKTMDLESWYDQHWTPIWTKYLLAEQNEKLEKEKLEKQQSGKGRKDAARDVVAEKEKEKRVVALSWHNKLVWHVESWTTRVEGPTSENKFDWMETMADDRFVVYARRLVARIEDALQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCM1</accession>
    <name>A0A6A6QCM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2489207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="60947" checksum="6BDC2286A304312C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEG9</accession>
    <name>A0A6A6QEG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_152225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEG9"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="13"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2490416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="245" mass="26687" checksum="D66C9908D87046D4" modified="2020-06-17" version="1">MADPGKVDTSKKHFVPLENNPEVFTHLVHLLGVSSKLGFYDIYSIDEPDLLAFIPRPVHALIFICPAKAYRKTREEEDEAIPAYDGSGEAEPVVWFRQTIGNACGLIGCLHAVCNGGARKYIKPGSDLEAILKEAIPLKPTPRAEVLYDSQALEAAHASAAQKGDTAPPPSFDHCGQHFIAFVKGDDGHLWELEGGWKGPIDRGVLGEDDDALSEKALQLGVRRFIKNMGEDLRFSIVALASSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEJ3</accession>
    <name>A0A6A6QEJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_470567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEJ3"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="206" mass="22981" checksum="1C5E3426BD4F8ADE" modified="2020-06-17" version="1">MSLDPTVAHLVDTAAADPDSDEDALIASLEADEAVDAFRERRLQQLHEEFNRAKQLRSSAHGIYSEIKDEKALMDITTSTKYCVVHFFKPDFNRCAVMDGHLESLAPTHYETRIVRINVDNAPFLITKLKIQVLPCVIAFVDGVGVDRVIGFEGLGRTPDTFTTRDLEARLIRAGVLVREKVQGVRKGTAIRKGKVVEEDSGDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEX4</accession>
    <name>A0A6A6QEX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_531070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEX4"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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</entry>
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                <person name="Bloem J."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </dbReference>
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        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="363" mass="39582" checksum="185729815022E844" modified="2020-06-17" version="1">MFNPGFYDDDDPMAMYQQAILRRQGGGQRRFDEYFRCYPIAMLPGPEREDANHGGKVFLPPSALDKLTRLHITYPMLFELINGAKDGKQTHAGVLEFIAEEGKIYLPYWLMQTLEVEPGDLLQVKSTDLPLGTFIKLQPQSPSFLEISDPKAVLENAFRNFACLTTGDIFTFSYNDNVYSIAVLETKPVSDKKAICTLETDLSVDFAPPVGYKEPERNTSGTSTPRSGTGVMAGKGGTLHSHGTMAQAINYAAIAPSSTSAAAGAKAVSSNFLSGGHKLSSKKGSKAPTPKPSTPVAGSSSNAPPTVLRRTNGPQPLRLAPGKLFFGYEIKPVKRKGEDEEKEKEKFHFQGQGQSLRKKKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHJ9</accession>
    <name>A0A6A6QHJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_493191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHJ9"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="50569" checksum="30FC5B30FC5380C7" modified="2020-06-17" version="1">METGTEPLIAHLKDVFLDLAAHPYPEVANPPTAPRRASVALILRIQPHYSHWPAARTKHAHAPSHGHQRRRSSAASNPDKKLELKDILDAFFAQDWVKHGDPELLFIKRATRAGDNWNGHVALPGGKRDPEDEDDQVTAVREAMEEVGVDLSYAHAIAIGNLPQRVVTTSWGKVPLMVLCPYIFLLTSPSIPPLRLQPTEVASTHWVSLRALLSPAQRTFEYADVSKRLAKSELGIKRWFLQSMLSQMMFAAVRLLPSESTYCSSIPGFIPELEDSAGVIGSIKGWWTGDTAATTTQKPLLLWGLTLGVISDLLEHIPPHKAMDMWTYPTFTSWDVRITLWAMSYRFRKQKAIEMGQAAEIPAGTEENMKVPKQDPQGMPVEEEPGEVGIGGLGVGRHWGRSRRDALGSRGSAVNSMLEGYYPIVRKAVATALVGRISVTALLLAYAWSRYSKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIP6</accession>
    <name>A0A6A6QIP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_530300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIP6"/>
    <dbReference type="OrthoDB" id="10500188at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="179" mass="20047" checksum="727AA6AC88DE130C" modified="2020-06-17" version="1">MINQEAPSHYKLEESTTPISSTPNMTKDPSTRDHKLHNLSTASARIDEMKAQIKDQTTQIEDLLQQVAQFEMEKSAAAARSAERYVKKLDAIFDIALYHYERDSVSRRDLEGLLKMARQCYTEAFVPPTNIKASTTTKRTATKPTASNEEIDLVALVTSVVVGIVIAALFICIMQVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIU9</accession>
    <name>A0A6A6QIU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_110747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIU9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="17924" checksum="74C18F3CAC927079" modified="2020-06-17" version="1">MVAKRTAQPSGSDGHYQRSQSVCTLADRDYLLNQNSNRPGGKARGFWRRKYQRFFPKKRAMRTPGPEERRKSQNWKDATVKLASRNTIAIDHPASDFPATVVTMRGTGQTINRLTISGPMPISPQSPEEKAEADAIKLECRGMMRRSTQRQAMSMIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ31</accession>
    <name>A0A6A6QJ31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_542312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
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            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="209" mass="24141" checksum="7C16D0142B25203A" modified="2020-06-17" version="1">MPLPSSLPTYPPSFYALVSFLLAFLFIIYHALPQLTAPRYSRGKHQPPPPPRPRPRPPPRPTPPPPDNSNRTQPHLPALHAVNLARPEDYTPVPIPTFLDGFLVNEAMHNTRHFRAIRARAREMRNENQRLRNQEQEHRQQIQAMQEQIQRYEEELEVMQCSTTAQTSDSGSSEMSQVGEFPRMNDARFDRFNAYHGRGGGEGPWPQFW</sequence>
</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR024535">
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            <begin position="25"/>
            <end position="782"/>
        </location>
    </feature>
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            <end position="289"/>
        </location>
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        <location>
            <begin position="413"/>
            <end position="471"/>
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            <dbReference type="Pfam" id="PF12708"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="782" mass="83551" checksum="A85EA8FF7B48DBC6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJQ2</accession>
    <name>A0A6A6QJQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_529550</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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    <comment type="subunit">
        <text evidence="2">Monomer.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QJR8_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJR8"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="28252" checksum="2074178C74180E67" modified="2020-06-17" version="1">MIFRPEPLDIEPFELARTVLGPVVPDVQLLKDENLASEGIWAYWMTCTPGKTWLDGARGRRSQSRVTTGSSKLVIDNKLRPHLELLLSSPNERSYEFRDFARDLLGKLDWLQILPLFVSHFDLNDINILVDDNCEVSGLIDWELSTRLPFGMGFGRIYTLAGEYSDRKFHMPPEFEDAEKGFCEEVYKGIPAEVRKSIEENPDIVQIAVTLGTLLNAFRLDDDVIGSCNPVVIEALPKLLTYRIPVIRG</sequence>
</entry>
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKN8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="94" mass="10699" checksum="BC1D89746AE0F514" modified="2020-06-17" version="1">MPARFSSTGSPQRQQSHTPHMLCRQRPQSQHSRRDDVHRSAPGHGPDCTPNSFLPRVRGVWEKQVDGHEVHAEKAPFPARNEAPERNRLLYLGS</sequence>
</entry>
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    <name>A0A6A6QKQ2_9PEZI</name>
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    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="32673" checksum="A8C2BBF2652EE343" modified="2020-06-17" version="1">MASHEPPNQPSSSIMDFVWTGASSELDIAKHPKTTAAVCRVNQQIRLEAMPYFLSAHAFTIDKRGDAEGLEKSLERWGGLKLVKHLRIDGWWIGIKPGQRIVNYSGDSPFFSIPLARLDVSLDLEFMEKCLNLVTVRLKMAPHREPSVNPGGKVRYLQCTQLRSEGAAEVHRRQLSLAQFLEWYHMEALSHNEKLREVNLVSTSSCRYCYRDLRSDVCRGVLDELRAWVKKGFEERGRKVETDVLAYTWRNNWRSDGRWVMITQREPQLGINQFNSTLRLISGQ</sequence>
</entry>
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    <name>A0A6A6QM48_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="24301" checksum="3A50CC7A3F6C21EC" modified="2020-06-17" version="1">MAFLPIFLSCLLLSILSITNLSLISSMVAWLHIQKTQVKSYAIDWPNGPFHLEALPEHLWLDQGHTSNGVAGYGFFLGLVGLYVAWRQRKRQGRGASKTLLALVVLLSLAVVFTIAALAFVFTVAHDTKGQTIQSAIAKPGVKYPTHKWTPVTWYKAVLKLPLADDSVRSNIKSHVTNIEAWEYMLIPIFLTDLLALGIAVMAMMKQRKGQPSEISTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNS1</accession>
    <name>A0A6A6QNS1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16991" checksum="3DF121192FA3FBA4" modified="2020-06-17" version="1">MPDLATTHTEWPSIGVAPSTKALLDDFFEILDENTADAGQKLADRIFTPDGTFITSSSKFTGVDEITSSRERAWDVVKERMHKLVKVYTSTDDGSDLLAIGDASIVLHKNNIRIDGNLIARIVFKDVGTDNVRIKYFQVWGDSGPMMKALQDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNU7</accession>
    <name>A0A6A6QNU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNU7"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33113" checksum="DF14AA7C7069EBAE" modified="2020-06-17" version="1">MMTLPSASKSSHCDQLESPDVGNFAVSVFILIGILISYLPQHYRIISRRSSLGLSPMFVLLGTVSGTAAIANILTLPASRADMACCTEISRFACAAAMLGVAQVGVQWTCFFFIMLLFLIFFPRRPSRPSTPTPTTPTSPSSSPDHESIPTWAEAILVLLFSLAFFLFAFLTSLVFIYAAPAHLQGWANFLGILGTILASIQYIPQIWTTWRLQEVLSLSIPMMCIQTPGSFVWAASLAARLGREGWSAWGLYIVTGCLQGVLLGMGISFVVRDWRRKKGAEGAASGEANGHGNGASERSPLLQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP29</accession>
    <name>A0A6A6QP29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_463913</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP29"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="257"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="569"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="78"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
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        <location>
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            <begin position="141"/>
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        <location>
            <begin position="159"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
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            <end position="738"/>
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            <begin position="852"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1132"/>
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        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="336"/>
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        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="11">
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            <begin position="385"/>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="11">
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            <position position="399"/>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022527"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2494268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1143" mass="123494" checksum="18D034C8467DB48E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP70</accession>
    <name>A0A6A6QP70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_550859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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    <dbReference type="OrthoDB" id="5296287at2759"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="812" mass="89721" checksum="84638C8638F0128D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPN3</accession>
    <name>A0A6A6QPN3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_589353</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5429634at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
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        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="23"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="53845" checksum="A896905A25A0E47B" modified="2020-06-17" version="1" fragment="single">GFITSAFVLTANVVCLVVFHVKYGSKSNRGVIPIYNGDCNWVKNAGIFSHICINILSTLLLGASNLCMQLLAAPTRDEVNRAHRKKVWLDIGAPSLRNLKYIAKSRRILWFCLGLSSIPIHFMYNSAISTSIPLYGYVTIVASENFLHGADIGNWTEITSAGVDPVRNRVPNIDTWNSSQEFEKIQANAPDISIFEKLSNRDCVEKYAKIYGARTSLVVITEALPEDRNASVHQYIFWPAKFDFGSRYNPCTGLYNLQEGDYQRTNPSCRHVSSNTQADYDNWHRFNRTVLYCLSEKLHGSHCSINYAPSIFLAICCFSTLKCVCILATLSHKQPTLSTLGDAIASFLEDPDDASAHMGPVTKVMFKSRKSRVWTEPSPLLWLPRPLRWYSGPSARRWIFTITVYTLAISGALASVIPGIHGTKARSGKGVSWEMKQNIGRADSDSFNGYSLPKYGTLAFIENVIWANMWQVILLLYIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ61</accession>
    <name>A0A6A6QQ61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 125 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_512712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH125"/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="14"/>
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        </location>
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        <location>
            <begin position="25"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51611" checksum="5E954FF9DB587D0B" modified="2020-06-17" version="1" fragment="single">MSTMRTLKSTGSGRFEKEDPIAKQRREKKRIQNRNAQRSHREKQAAYIRTLEKMVSDAVPAGGQMPDAACQSAQTQANWIEEIRELQEALLRMRKKFQSLSFAAASNAEDLIFKRILNLQSLSRAETPRSPRQPQQGTPFHIAQSVESVLDPSGTLIEWGQDTDLATLFADDYLHNGAPPPSIPCSHSEFNQALVLQPNVCVSPPGSVSSASSKSSLAESLRVEDVYPSTDILGVERTLKTVLEQSENRADVDRSVSLAVRIMLKRSPLIDGIFSLMGGAEAVERVIHWRIAPTAANRDKIPAPFRPTVLQQHFPEHNYGIDFLYWAELRDQLMLQNDIDIGQLVEDCLRNLVQEVPQLNLSLPLVETYFHLIELVQTNSEQQLPSPVERFLDLTYSDDDREPLRLHHPHYKVFRAVEKYQLDELSNRKMMPNFAEKYPSLDLTNIITKFPVASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT98</accession>
    <name>A0A6A6QT98_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_487251</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="33954" checksum="912F07E9DA681933" modified="2020-06-17" version="1">MTSCNLPYFADEASLPAPLPTVQEIDSATETIQNTSGRKIAVVGDHFIVKYGVHVDLLEGETTLFLGKSTNVPVPRIYALFQSPDKRCSYIIMERIRGSTLDVEWPNIDQARKEAICSKLHAILEEMRKLESPGGYCSVGGRGLPDSLFWTMDPSDPFRGPFDTESDMNEAMIAKYVADGLSQHKANFYSRTFKEVFQNHKPVFAHADLQRKNIIVRFLPTATGVEQQRDIEHLDLVIIDWEYAGWYPSYWEYARAMWACGRWQDDWNYWVDQMLDPFRNEFAWVEMLLKEMWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTN5</accession>
    <name>A0A6A6QTN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_390743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2495474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="104" mass="11722" checksum="C0EC630A670D00CA" modified="2020-06-17" version="1">MRPFRAFDSFQTRENNVMNQAVRDGHEGNEPRTGFFAFLTFFAGFFSSSSSSSSSSSESHALASYIPNFTSPFLLECPQYLKTAPKISKHPAQYRIRGAYHGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWL1</accession>
    <name>A0A6A6QWL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_342904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWL1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="109" mass="13075" checksum="084901D351C457C2" modified="2020-06-17" version="1">MSSDDDRRRREKSAEEEYDYLYETLEQQDYDAITRFHEYLKHFLTYGAYWKTWRGRRRLIKRWSEMSEEEQIAAIAEPGPRSPSPSSSEDGRITKDIIANGEWVYVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX33</accession>
    <name>A0A6A6QX33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase group protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496712.1"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYS2"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="333" mass="35815" checksum="0AD595A7FAFAD09B" modified="2020-06-17" version="1">MGWASHFIYSQFFLTPPLPITPLNSQVYIITGSNTGLGLAAAAHLARLNCALIILAVRSEARGRAAVTSLVASTGRPASSFAVWPLDLSSFASVRAFGERVAGMERLDAVIQNAGVLREDWVEAEGMESTITINSVGAVLFGMLMLPKLRESARKTGKMGRLSFVGSDLQMQAKFTENQGREEAGLSVLQALGDEKKANMGDRYSTSKLLLILSVRALAQQSPLTPESNVLINLVSPGACQSDLFRSEPSFGMKIVVFLLNHIIGRRTDVGARVLVNGASPELGAEAHGAFIWDDIRSPGGLAEGSKGKALQEEWHKELWAKLESIHPGVTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ12</accession>
    <name>A0A6A6QZ12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_459039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ12"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="181" mass="18787" checksum="67D41062A082BC9C" modified="2020-06-17" version="1" fragment="single">SESVTPSHLPHLTPSGSAHMVSITAKSATARTAIAVGRVRFSNPAPLPLIKSNALKKGDVLGVARVAGIMASKKCPEIIPLCHPILLSHVGVELALVDSGDEGTDHGAVEIEAKVQCTGATGVEMEALTAVMGAALTVVDMCKAVDKGMVVEGVTVVLKEGGRSGTWRKDGWVSRFDQLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ33</accession>
    <name>A0A6A6QZ33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_571450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ33"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="392" mass="44381" checksum="0227E024B6031C59" modified="2020-06-17" version="1">MLAAVFVGLRIYTRRKLKIRLGWDDWLIVAPLLLSIALIGPSYKHVKMWHVGIHIWEVPVNEIEPNYDDWYPVVLAFNLLNIPIVPLVKASIIMLLLRVGSVLRSIRWALYIVLVFNVGASIVPWIIYIFMCPPQTGNTWKPRTFGELHCVGRHRTGEMLIWVTCANLLTDILIFPIPFLIVRRMMSARLRSRLVVIAVFTSSLAVTGIGAAKIYLSYRDRLYSLFKPDWTYPIDYCINHIENNVAIMIANVPILRGLVTRWVFNFRTKPTPMDPEAQGGWSTSDSSGFTRVARVAHESRFARALLPCMVVPQSAGSRESEYAVRVTTEFRVDRDRKRATSLDTFDDVDSEKGGALETVTSVGSLTLVDRAEMEAKIAELSPISPCVIRGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZU1</accession>
    <name>A0A6A6QZU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">BU16DRAFT_483882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZU1"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2496667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="98" mass="10608" checksum="CF7F28FF72E33C09" modified="2020-06-17" version="1">MSLSTYLNKKVCIITTDGRTLVGILISCDHNTNIVLQDTIERIIVPADSGEKSSQADQGLYMIRGDSVVVCGEVDEEIDASINWEEVKGEAIGGTKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0F0</accession>
    <name>A0A6A6R0F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_525326</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0F0"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="286"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2497714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="523" mass="60432" checksum="D698DD80660F45DE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Q5</accession>
    <name>A0A6A6R0Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_330170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Q5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="164" mass="17818" checksum="1CDB90F375E2D00B" modified="2020-06-17" version="1">MQIFITNTTSSPLALVPAYHHSPAPNGQRSDTISWQSRHRDGLGCGDDAAATVTRCQRHSGWGAKQNMAGERFASLALHAEAKPSSTTCWPVRGNTLRLCRGRLRVRMANTWYKAVAIEAAQRPERVVDIWLGRLLTSTQCTVSLGHGGCTCNMPVSLGFSAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1C5</accession>
    <name>A0A6A6R1C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_526248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1C5"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2497227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="17288" checksum="E841696465409F39" modified="2020-06-17" version="1">MSFVRAASRVRPCLRLGVAAAPARRVLPMQARRAFAQTAARKNDDPHAEESFEEFSARYEKEFDAVSDVFELQRNLNNAFAYDLVPAPSVIVAALKAARRVNDYPSAVRVFEGIKAKVENKGQYEEYLTELEPIRAELGIVLKEAMFPDTQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1I6</accession>
    <name>A0A6A6R1I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_456153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1I6"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="67" mass="7813" checksum="7EE8E83B7B450712" modified="2020-06-17" version="1" fragment="single">MSSTPTPWVTLGVARDANEKTVRSAYHRLAREHHPDKIRDPTRRTAGEEMFKIIQHAYELLTNKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R238</accession>
    <name>A0A6A6R238_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase subdomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_548438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R238"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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</entry>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025487065" evidence="2">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="355" mass="39384" checksum="665D4159DD88E05D" modified="2020-06-17" version="1">MRSLSTLGFLIGSLAVSGGYCTADIETRSLDQIHEAAKAEGGVVNLWAGGDEKDQQNGLKEAFETRFPGMTLNVTVDLSKYHDGRIDEQLAANNLYVDATFLQSLHDFPRWKSENALLNYQPLEFKNIFDQFKDSEGAYYGVFIFSWSNIWNTGKVDAASAPKEYTDYLKPVFKDKLALTYPNDDDAVAFQFDLIIKQYGWQWFDDLIAQNPRWVRGTATPATLISSSNGSYAATFTSGIGLTSSGSLNVSFPTQGQFVSWPQTGAIFADAPHPEGAKLLTNFVLSDEYQKASGWSVRRDLPGPSGYPTIFDMPGTNVTAFRDFMLDRAAVERLRFRFEDKIGTAQGLSPLVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3N0</accession>
    <name>A0A6A6R3N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_454389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3N0"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="44"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="205" mass="23161" checksum="84EA3AB571EFD94D" modified="2020-06-17" version="1">MSLFRPFFNTTHSSNQNDLFSLLNLLEEPVNRPQSLRRRLAETQQTLTFAPKFDIKETKTGYELHGELPGIEQKNVEIEWSEGNVLSIHGRTEYNRTEGDAPEKVQEEGWETTEAQGHDTAPATGSEKTEVAKTPAAGEVAAEKPKPKPTSRYWITERSVGEFHRSFSFPTLVDQENVKASLKNGVLSVIIPKKAKQEVRRIQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R485</accession>
    <name>A0A6A6R485_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_299443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R485"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="52445" checksum="53DF440E76B078A5" modified="2020-06-17" version="1">MDLLHLPIEIFQLVIETTLIQNGLQQALGMRLVCRLFDREVFRAICATKAFHGLAGIGYPKGPRIWSEYLQARVIAPGGPACRLVSIIRDTVDYIIQQRPLYKDHADEYLRSLCAHVCSEVGCGVWTVRYRFTFGPRNPPHDKLERYILSDHVVAASAYLGLTSLLEQLTEHGFHDEDSHFGTPVECAAQRGDVAMTHSLLLKMHGESEVQATSRKNALSVAAKNGDEAMIRLLFGPEYTKLVSCNDYVSAVSSAATGGKLRTVRFLIQHATDGGHTEGHKMSFMLLRGDNSIPWFPLWNTVFLDAAWSGHEDVVRLALNQGANINVSSKFFPGCRNALDGAAKNGHAHIVDLLLSKGAVAWPAKRCHRMYHCHPLYYAARGGWLRIARTLIDYGVDIDQFDDWHPLEAAASGGHVDVVRMLLERGADVTINPTVGRKAYSIAESRGFTGVMVLLAEYGLKIVGKDSDTVIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4A8</accession>
    <name>A0A6A6R4A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_523853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4A8"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:SCF ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="524" mass="58026" checksum="24817B7A9C637A21" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6A1</accession>
    <name>A0A6A6R6A1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="15">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_452693</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase C19 family. UBP8 subfamily.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein deubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="183"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2500111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="532" mass="59067" checksum="EEA83CCD87691E00" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6J1</accession>
    <name>A0A6A6R6J1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ring-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_478835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6J1"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46164" checksum="B4A98C29F8CBDCBB" modified="2020-06-17" version="1">MVLEYFTKHTNKHQHAENGEHNAQTPVLNDEDELFLQRITSEGTPPPLPERPVVILDNGTKLQGKDAQTALMNGAEKVPLPTSPPVDSEGKELIDDVQKTTGETSEKKSRKFLSYLPAIPGRGKGKAKEAAAADLHAIAASSKPGAPSLATAEEEKEQQDLTAILDDLNLSAVNNRVFSFSKESQELLDKFKLVLKDIINGVPTAYDDLEKLLTGSEAQLKKLFGALPPFLQTLVKSLPAKMTATLGPEFLAAASEKPGFDAMSASGSKPSRRPKIPSLKSLVASQGAVATMLKSILNFLKLRFPAFVTGTNVLMSLAVFLLLFVFWYCHKRGRETRLERERVDAEGNPIGGESDVSDLEDSTVLEKPRDTDVQPPLIIHPDSGAPDKPSATVSDMPSVLDLPEPATVPLPEGTTPLKEEPIEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6U3</accession>
    <name>A0A6A6R6U3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6U3"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="186" mass="19889" checksum="D6C0F2A2E61CBBB0" modified="2020-06-17" version="1">MALSQPVLSFLRPLGPPRPSSFRHLLRFSTASRLSLEASASPPSASASAASTSSTPSPPQSRDADIAAAEAATDADNPTSPIPSLKALPSQRVPSPASQLQKELKFHVARTPSNFLPVYKDAKAGGNKHLTTVRKITGDATQLRDELSELLALPKGHAFINPVTGHVVVKGWYKNQIVKYLESKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6X8</accession>
    <name>A0A6A6R6X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_547787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6X8"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36841" checksum="3BDF78EF4AD30D69" modified="2020-06-17" version="1">MSFHDRITNLPSFDELPQIGDLPKGCTWGLWDKDGKKDELGTLNLLTPEVVKEAFKELSEGVSVCLTWSLDKPNAPNFHRKPLDHKLLDHSTFSPYSGFDDEIHLNTQCSSQWDGLRHHSQGQTKLFYNNVNKEEFKTSNVLGIDRWSTRGGIVGRGVLIDYVAYAARHNITYSAIECHSITHTALEAAAREQGVAFKPGDILLVRSGFTKWYNSMSDNAAERDRVTSSQFTYAGVTPTQESIRWMWERHFSAVAGDALAFESLPYRDDGLLFHDFFLSLWGTPIGEAWDLEGLAETCERLGRWSFLLTSAPLNVPGGVASPPNAIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R702</accession>
    <name>A0A6A6R702_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_556839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R702"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="428" mass="47057" checksum="3C3D3A1DE2A15058" modified="2020-06-17" version="1">MEALSGVASAFAVVSLSIQLVDNINTLCEFWEKVRGAPKYIKELVQELRLLRSVSTQVDSLMAIMAKVQGGLSSGSRIVRTWNSFKVSLKGRQIMQFRLSLSETKSTLILARFSLSEKIHYRIAEQTMTALTDGLASLSVHRASGTVMTEIHDSLDMQGHIASLQAEMRHVTASVPQSWIRSGMQVALDNAVRGMADKLDVQDPVPPKDQGGSDTRRGRTATPSGYSGSHPDVESGQDASARLESDSRNRRNRRLGTDSFHGSYSSITSSVFGTIYLSTDKFYIDDPTFTDDSDEEGAHLGRILYRTFHAVPDNALIFEFCKQGNLMAVNSLLVNGQASPWDTNSKGWTPLHFASWNCDLALMKTLVRAGADRTALTFDFPSGNYEHCSPLVTAATITSVIEVSPQRRIEALRLLLDDSDFSDHEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7E6</accession>
    <name>A0A6A6R7E6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_614071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="712"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1140" mass="125844" checksum="CA048901F64A2D3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7X2</accession>
    <name>A0A6A6R7X2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L13e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_502965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7X2"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="214" mass="24225" checksum="A2B5CAD414475C5F" modified="2020-06-17" version="1">MAIKHNQQIQKNHFHKDWQRRVRCHFDQPGRKLRRRNARVAKAATVAPRPVDKLRPIVRCPTIKYNRRVRAGRGFTLAELKAAAIPRKLAPTIGISVDPRRQNISEESLKANVERLQEYKKRLILFPRRHGKTKTGDASAEDVKAAKKGDTLSSLASVLPIKNVIEFTEAKIGSVEKTESPYKTLRAARSEARLVGVRAKRAQAKADEKESAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8B0</accession>
    <name>A0A6A6R8B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_188527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="199"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="897"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="917"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2501035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1110" mass="121590" checksum="430A52B80E89908C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8D9</accession>
    <name>A0A6A6R8D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_557121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R972"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="196" mass="21600" checksum="B91690D9FA8D4E6B" modified="2020-06-17" version="1">MSLVNLAHVCSHLQNASKARLGLTSIPVTKLHVALMLGLQKQGFISSVTLGGPAPPKPVLLQKPPKYPPALLKAAEQAELEAEEAATPEVAWGRAPEWSYKEVVPANPGQRRLWVGLKYWKNEPVLNKMHLISKPTRRIWVNSDDLAKITRGRESAFVKGLTKTGECMFVTTDKGIMEARECVEKKLGGMVLCRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9A8</accession>
    <name>A0A6A6R9A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase/succinate dehydrogenase flavo protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_555631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9A8"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF10">
        <property type="entry name" value="3-OXOSTEROID 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="550" mass="58476" checksum="DDC4B19D4E2D0442" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9G9</accession>
    <name>A0A6A6R9G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_533845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9G9"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="276" mass="31186" checksum="7F9CB710175D0DCC" modified="2020-06-17" version="1">MLHSLKFEEYKDAFRYLTLRRENGILEVRMHYNDGPAKWSGYDVSLHSELPELFQCVTKDPENKIMIFTGTGHEFLAEWDRTDETEVLVSPQQWHRLYKDGKELIHWFLDIEIPIIAAVNGKCFIHPELPTLCDVVIASETSVFADKAHLTDTRAVPGDGSHVWWPMLLGPNRGRSFLILGEEIPAAEAKTLGFVAEVVPQDAVLDRAWEIARTLITHDPLVLKYTRISLTQHMKRRFLDDLGYGLALEGLGILSLAQNASKSKGWSFSLPSGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA18</accession>
    <name>A0A6A6RA18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_453222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA18"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="528" mass="57287" checksum="834325F1182ACFBC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAA3</accession>
    <name>A0A6A6RAA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_569640</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAA3"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="17">
        <location>
            <begin position="6"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="18">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Mondo S."/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="125" mass="14227" checksum="E17AC4BA52D719B0" modified="2020-06-17" version="1">MTEVAAFGGRWWRICPSHKTVIRQPCARKLLSCLQNALSISNLFVILSHAPNRLLSKYRASRSPLRSSRVQHNEHGARLPVFVPYDSPVRLQAPNQTPIKRASRPLSLRPLQKVLSLTLRLCKRP</sequence>
</entry>
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        </lineage>
    </organism>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="390" mass="43963" checksum="E7817342A6D0666C" modified="2020-06-17" version="1">MGGIVHVIQSAHQSAHQSASHDILIKGSRIYLSRCNSSFDRHSNLSLLVSSHQNFAPRHSTSTTLRPPATMPSQTSQNKHRSMYAPSYSTMLRTQDSISFEDILAVPFQSYSNLEIFKSIEKYEEESNRRKASGLAFEDCVLKTYLTPKDSWNKSLSSWHAAHEGLFAAEHALSRRVQPLTRRDDYIPTLMSLMRTSVEAAICVAQGARDPTTVFWQRLGLLPHSGEHKNSRSLQQHVNRLVQIIRLEIKRIKRRSALFLGSCFRGPAIGDREDHSECLICRHPYGGVHHLPLKLICGHVWGTKCILTWVSSNNGNSNTCPKCRKVLVPPRDWMDGFNEPVQLVITQLAQICNLYIAVAGEENYEASSLPELVRDMMVFVDILQNGGCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCT4</accession>
    <name>A0A6A6RCT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_612310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCT4"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="289" mass="32086" checksum="E4F91DDEF9D7C2AE" modified="2020-06-17" version="1">MSSDPQPPAPAPFYTVNEVRTRLQSHFLDADPSQHPSRWDDLWKSQDFLPWDRGTWNPALADVLSEQTALLGTPTILDEATGVKRRKRALVPGCGKGYDVLLLASFGYDSYGVEASANAVRACEKYAADAADAYPARDTEVGSGSVKFLFGDFFKDEWVEGVDGGLGDGFDVIYDYTFLCALPPSLRPSWAARQSQLLAPTARLICLEFPTHKSPSSGGPPWALPPVVYEEILARPGEEVTYDEDMNVIVQTPVRDNEKALERLAHWQPERTHEAGIGTDWVSIWKHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD09</accession>
    <name>A0A6A6RD09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_477432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD09"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="167"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="323" mass="36336" checksum="819AC4EA930D3FFA" modified="2020-06-17" version="1">MAADAPPAAAPAAKIKILRLAHVYYKHKNIAAAEQFLKDFGFLETERVGKKIFYRGYGTDPFVYCAEEGEEDEFGGTGCVVESLADLELATKIIETASPIYDLKTPGGGKCVTIKDPVDGWPMHLVYGQTPVEPSAEYGYLDFNFPDVKPRKNKFQRFEKGPAIVHKIGHFGMCVTNFAKTYEFYTTKFNFVASDLQHEGDGVNVLAFMHLDLGEDFTDHHSFFIFQGPKSHVHHSSYEVHDFDTEVLGHDWLRNKGYKNCWGVGRHILGSQIFDYWFDTSGFILEHYVDGDQVNCHHETKVSQAGPDGLHVWGPDLPSGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD20</accession>
    <name>A0A6A6RD20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_16275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD20"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="164" mass="17433" checksum="EEB3AD187E201F95" modified="2020-06-17" version="1">MLAMACPCRFLGVHANPALWDPRKGQTRLFQTSGKSRSNGQRRHARILGIHRNCHTSYAPRCLSRAHRHRLRDIACGSPKTTPAEAACPQHRLIGEPVDSHCLAASLSLESDRSHVEAGAVCAIGQTAPQRATFSSADASGTSRLAALAALAGLARQRGGGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDN5</accession>
    <name>A0A6A6RDN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_210752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase family protein (AFU_orthologue AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase family 92 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025640284" evidence="2">
        <location>
            <begin position="23"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="274"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="766" mass="83728" checksum="E2C398E697250EF6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDW3</accession>
    <name>A0A6A6RDW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_522798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDW3"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2501923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="435" mass="47060" checksum="0ABD1F9F2E9C6BF1" modified="2020-06-17" version="1">MLIAGRAIQGLGAGGVNVLIETVICDIIPLRERGKFMALIFGMITIGTALGPVFAGLIVQYSTWRWVFYLNLPVGGVAFVLLALFLKVKAGEGQAGRGFAEKMARLDILGNVIFIASCVSALLALGWADAVYPWSSFRIILPLVLGFAGFGAFLWYEGSGYPVEPTMPLHLFANRTSLVAFLLTFFHGLLTVYVLYFLPVYFQGVLMSSPGRSGVQLLPTVLVMIPFAAAGGGLLSKFGKYKPMHVIGYGIMVLGFGLYTLLDEKSSTAEWVVYQAVESMGAGLVVGVLLPAIQAKLTDADTAKSTATFGFVRSFGLVWGSAIPAAVFNSRLAELVGKIEDLGVRAMLADGHAYEHATRDFVKSLSVESGARQQVVGVFVESLKRTWQVGIAFTGIAFLLTFLEESVELRKDLDTEYGMEDLKEKEKEKRMTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REM1</accession>
    <name>A0A6A6REM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_588685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REM1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2503129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="190" mass="20836" checksum="E180055A6901BC4A" modified="2020-06-17" version="1">MYVDDSAIAHALEWVRRRVVSWSAGFAAALRMASGMQIPGLEKFHEAGQDVFKQFFSQVANSVLRDARVVVRPTRQTVRGVRGQNEARKCRQIVPQPASVVLQWANMHLDGLSMHLKQTQCGDIHSQQTGRSRLHSQQINRARHAGHAPSSCLSRVSLACAALPPLYLVLVFLVEVAPAGGCCRTVSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RET2</accession>
    <name>A0A6A6RET2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_612740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RET2"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="38990" checksum="DE5B29676ECC2760" modified="2020-06-17" version="1">MEVFKGGGEPPDGDGGQKEEPDGEVICSDTDFKILKFSDGKIRITRSGHDVVVDLAFEGNERVATTFNAFNKEDRFIASQEIVSHAGKKVEIEISTHGRRKHTFPFFELPAELRNMVYGWVLENESYEFCGYKMRLCLFRARGLGHSGTVSNIAPPTGAAGFFLPHDGRFRCLDVNRQIRSEFAPLAIERTTFVLAKGCSNSLYNDLELACAFINGIGEIGRANITAIDLGWWTSEWHVNKHFSPRSTAWFKSGFSKALTKLLKSCPRLRWLDVTIPYRCGLGSGTLKPNDYSWACGLENLRSLCGFVPHVNIISKDNEPLKNWLMAPVATKRSAEADDASESRKKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RET9</accession>
    <name>A0A6A6RET9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_546048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RET9"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="205" mass="22738" checksum="8FFEC21AF29D203B" modified="2020-06-17" version="1">MAAAYPPNGTFFDTLKKSFVDVPVESGKDNAVPTTEFLEAAESLTTLFDVLGSMAFNPVKNDMLGNVKKIRDRQLAAPTLSETLQDLVLNELKEKKHTATEGLLWLVRGLDFTAQALRANLNNSSEELSASFRSAYSNTLKPHHSFLIKPIFSAAMGATPYRKDFYAKLGADQDKVQAALVPWLEALEKDVTVLKEFLARKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REV6</accession>
    <name>A0A6A6REV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_554340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REV6"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="40348" checksum="B8BB479ED190CC08" modified="2020-06-17" version="1">MAISRVAEVAASLTITYVAAITAVALRIFSRRLTGVALAFDDYSAVAAGFCATVFFAMKVYALTNGLGRHIQDVHKTTPVITTQHIMRDLWADDIPYSVGVCLAKLSILWLYWRMFKHSGIRIPIQIMAALSVMWFIARLVMTAIQCIPIHALWDYSVKGVCPIDPAKSFIATCATHAIIDFIIVLLPVFEVAKLHLPPIQKFSVALMFTSGLLVACAAAFQTYNESNWVFADPDRSWTVARLTIWQQVELNMSVFASCLPVLRPAFKVLTGQSLTTTASESRKYARSGKPSTVSSGRLGALLNKRRGIEAIESDSTYELSREANKSARSNLWNSGPHNQEPGITPLHMGQVGRERIVWEDKAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF72</accession>
    <name>A0A6A6RF72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secretory pathway Sec39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_33268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF72"/>
    <dbReference type="OrthoDB" id="3434013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
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        <location>
            <begin position="13"/>
            <end position="856"/>
        </location>
    </feature>
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            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="917"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2503221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="989" mass="109386" checksum="4EFA03151C11367F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFR8</accession>
    <name>A0A6A6RFR8_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_521909</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2503324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="20049" checksum="7973BDC8150EE5A6" modified="2020-06-17" version="1">MAEDEGASPRELILEACRRNNASLLEETLADLTSASKKAGKKPVDFIAEVLNKSYDGVGNGCLHIAATYGSYDVLDVLLDQEGIEIDEIDRMERDTPLHKAVRYVNSLSKAEWSSGHHVVDILLDAGCDPRIRNKAKLKPVELVDPRNTELRSILQKGEFAMTAGDDVVHEDDDGPTGSGSDSD</sequence>
</entry>
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    <name>A0A6A6RG44_9PEZI</name>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <location>
            <begin position="59"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="346" mass="38649" checksum="3D89409D18B13880" modified="2020-06-17" version="1">MAAAPLTAEQLVHHPEFKHISWPLQPAAKGKVSVAAGRGGPFSIAYEIHGKGDRRLVWIMGLGGLKTTWQRQTKDFAHTKGDIYTSLVFDNRGIGESDKPFMRYSTSEMAKDTVELLDHVGWTDNRRLHVIGISMGGMIAQELALLIPDRICSLSLVSTASGLFNTVGYFENLRNRINLFIPRAIDVQLNNVKRNMYTAAWLEKPDDTEYVVEPFPTNGDRFAAFEIAKRSNAAAFSRTGFLAQAIAAGWHYKSPAQLKSISEKLGKKRIMIVHGGSDRMIPFPHAKVLQLGLEGWDSLEAAKETEAEIETHFPVDQSHVIPIEMRATFMEWVEGLVEKTEKLDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RHW2</accession>
    <name>A0A6A6RHW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BU16DRAFT_476236</name>
    </gene>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2503380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="269" mass="29116" checksum="2186F16032C6EE1B" modified="2020-06-17" version="1">MLIQESHVDIATQAGGDMRLFVFHPTIANYPKAKFPGVVVFSEIYQVTGPVARFCRQIAGQGYIAVAPSSYHEFTGPEALAYDGPGTDAGNEWKIKKKVSAYDEDATLSIDHLVSLPTCTGRIGAAGMCLGGHLAYRAALDKRVSAAVCYFATDMHSKSLGAGKNDDSLARAGDIKGELVMIFGKLDNHVPPAGRDLIRKTLHDAGLTFSFYEVAWAQHAFIRDELSKGRYDPPIAGICFNMLTELFGRVLRSDIGPRSGEAVEVEDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q799</accession>
    <name>A0A6A6Q799_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_568426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q799"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="26753" checksum="7759C45FBCC2BE80" modified="2020-06-17" version="1">MAIPPRTQRNPTRPLSTRIRTLAATTASRKAAEAKTSARTEAAAAKKRAARQTLKPKSTGVKKRKATKKNLAARSRRKTSWGDAVAPIKTTKRLTGTGRRASEARKEGYTALPTPRVVKKTKKEAKKESPVASRKSSKADVPGSLRKSPSKKASVGSVVSPKKSPVKKASVGGVMSPKKSPVKKASVGSVASPNKSPIKKASVGSVASPKKSPAKKASVGIQESPSTATTNAHWSDWGHRGQDREPHFDHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8D6</accession>
    <name>A0A6A6Q8D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_568428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8D6"/>
    <dbReference type="OrthoDB" id="3768645at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="51330" checksum="FDBA4B1599348C44" modified="2020-06-17" version="1">MAPLTKLPDELIVAIFADVAYEDIFSLSKTCRHLRRIALPTLFHTITVTWATTERKNRILRNHSVGLLFRTIVQDSSLAALVKVVNLRVKDPSVYRLFEKPTDSYITPSEEALILKAVEIMAGQNKVYSKGIIFQDQPHLSAALLLQQCTGLQSLSIHALFLSDGILSHMIRMALMDPEPSKCLPWMKNMRSFTVEDGWGTPYLKQLPAVLRVEYHDATLLTTLQLLRTALRPGEVHLILSHTPNLAVLELDFLRPSSAQTLDLEILGLALYLTEEKLVRFTLRHEVFADEAVDVETLADVYEGTLCSLRTFYALTHLNISLGCLHGQTSAQEAPALADVLPPNLQQLTINDDLWGFDALNWKDCEIMEALKAFLTGERRAGGAANGDTDIKGVAWESGGEVGWKVATPELKEFVLDSRLRGWVYYDYLEDSEIREELRRKCKEEGLKCTFLFDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8Q8</accession>
    <name>A0A6A6Q8Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_545204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004201">
        <property type="protein sequence ID" value="KAF2488760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8Q8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="129" mass="13557" checksum="A982EA808DEBE83E" modified="2020-06-17" version="1">MATCRVIIGGLAAAGVGKAVVAAHMSQGISIQPGGWLTTRTRACKRREKRVERLKSSSLKTPVGNARKAFRLEAPCSDTLGTTVNGPIVFAGRSSRVKTTCSSTWSLSAEEGVVFARPSSYLGTTCPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9L2</accession>
    <name>A0A6A6Q9L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_601023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9L2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA76"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000427">
        <property type="entry name" value="Putative Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2488949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="118" mass="13597" checksum="A7078724C7429524" modified="2020-06-17" version="1">MQIFVKTLTTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCDKMICRNCGRDGIRTREAIWSFNHGVFTLGFWFHQSSFKQCEHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAK1</accession>
    <name>A0A6A6QAK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_531710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAK1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="76" mass="8480" checksum="6F71EF5DE42DE4B2" modified="2020-06-17" version="1">MFIRRGRQGQRTPHFAGLFPSLAARSASFFDLRFKLRNLSTPTLQHKPPHIPPYPPDPPVRSIFGPVFAVHASAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC78</accession>
    <name>A0A6A6QC78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_518732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC78"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="26524" checksum="24EDC2ABD612E21F" modified="2020-06-17" version="1">MPIQVDRITEADIDGAINTIQQAFADDPYNKWVYPDRSKFSPTRNRISLGLRCRWGIKHGLFYVARDPAEPEKVLGTAMWLAPHPPSQPQSWSEYFSSWQLWLAQIRMNLWYGRGGLSTARYWIWKDQQAKAQDVLWTSDQGYYFCNIVTVLPEAQGRGVGRALMEVVLQQADKEGIWCYLESSRDVPNVAIYEKFGFKLVKEMDCQEGEGKNAKITLYCMMREPQTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC83</accession>
    <name>A0A6A6QC83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_176591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC83"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2489263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="562" mass="63592" checksum="5652AC8E5D9737C6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCC4</accession>
    <name>A0A6A6QCC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="750" mass="75319" checksum="40B85CCB7F389669" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCP4</accession>
    <name>A0A6A6QCP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_553167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="30640" checksum="95E468133BCC952C" modified="2020-06-17" version="1">MAPGIYTPQAEPLLSPNAPATNHGSILQADGPALDNATLVTTDFYPLQFESAASRQLTTKLNAATNSSLLIASPYNFADQLLDLRSLDTPNRLFALALTGLTPTRPDYATAPYVDSLNWQAVLIQLRDLARAENFEWKEQSFYVVIFRSKLKEVVNRDLLHLLDQTSHVEATASGGLLKYWFGDPNSESRNLATCLWRSKEDARLGGLGPWHKKARSAARDLYDSITFSSHRFTIKDGITGWSFDQWEPKGSEVAHPHAPASAEDSCERALPASGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCP9</accession>
    <name>A0A6A6QCP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_544822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="319" mass="33710" checksum="8CC263B033D0B37E" modified="2020-06-17" version="1">MTSTRLFLGPPTLFSVLVIVGAIPGPVITAAPRLEKRYDAYGRSDFIGYFSTDRASSYNYLQCYGTQYGEIRTHGDWYGGCWYSDMASYFTTCSDNTAYGLFVSPYGTSTTSFYSSQSCTYPCVYDLMVYTPGYSSTSYFVECPAWSRDEVMTLYRTSLAVLPEITVASTSLDSTTTLESSSFSTTPTPTPTTASATAHTQTTPGPQTTTPVSPTATSTPQKKAPIAAIVGGVLGSILFLVLASALGFFLWWKKRRDAAANPSAGHAQPVHMSGDGGASAGGAAVVGGGYYGAPPEKSAAAITIPATMSPPPIYATQQG</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="1"/>
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            <begin position="17"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="257" mass="27641" checksum="B814D011717003B9" modified="2020-06-17" version="1">MLLFYLFLCIAAVVRSKPTSASRRDDPSEYILKCQSKPLKKGFSVFTKTDGQNAIQQFCNNKTYLDTRLTLPIEFVGDKTIKGNPQALQIHDVIPIDGGNSNLLVGLTLSAGDDYAEGMIVSTIFTGSTDAEKIGDCVTQFNKIMDGNTQFNKAIDGCFDGSPDTQQIGGSLSYYFCGEFNLVAVLKGQTDPLMAPTDFGAPKCSDAPVVKGVREGCICTYSSRPHQETRLCEPKAGCSSITNISGLAPYTGPQGCP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489603.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="213" mass="24280" checksum="5A6CE33FF1C8B91C" modified="2020-06-17" version="1">MASEPHAVDLVVGVLKCMKDSSVLTLIASVCREDENTLELIAQKLQNTPCVVAQADHSTVKAEPGESKNGVKLEPTESKANDYDDATGAGRRKRKRMDYNKLRYQTCKECGKQFDITKNNDEACVWHYGLMTPIFTFAERKEGESLDDYDTFIGKTRVYESSEDESLEARTLERHQFEADMIKKHPEVFRYSCCYGRPLSRGCRKQLHVVKEL</sequence>
</entry>
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    <name>A0A6A6QDB6_9PEZI</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="49620" checksum="7C1F745B196094DC" modified="2020-06-17" version="1">MVQIEHDAHAIKLHQSERTFLNTTSLTASMSSCPAASNAVGDTPPDVQMASPQGSPASSTEHLHPQLKLDTPIYDDGHFRFKDLPRETRDEVYKLVIGIDTPFTTTRRNKDPNRWAIFRVDRQLNQEVTAVFKDHAHIRMPIVVARAENFREYWTYPQLRAIELSCRHITLQLSMNSLRYRDTFDALERKLKHAILPTSIPRPETHRGKRWITIEIDEAFWWLLASKMWRAEVAADMESWERCMQLMERGNPDYDFVWTIKTALLPWLAEPEFRQPQLEVGPEEALDILMECIRLQSELCECESFGDEYFNYRHRSGPAWTVQSFRQFRKPSRALLNSTWCLNHTVEVRALVEMVKESCEKNGISYEVGTAQSLPLPNNLPEATVDAEWYHKKLADGVTYQMVLEHHRRRKSRCARLEEGTGRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEY9</accession>
    <name>A0A6A6QEY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_531396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEY9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="24939" checksum="D0DB9745E638DA4C" modified="2020-06-17" version="1">MSTPSSTMNHAPSPNTNNHIAVPRPKVATLYYIFAGLVVLVGIGGYFLWPQNPSLNSIANQNSSLDSIAKQSSSLDNAAKKVHVRPSKREPLPVTEHWDEDDWMAKGRASEFEDELQAATVMAEWWDVGISNIHDIQPPTTMYEDMVASAIASASGGDAGIKNALKQLKEHSGGTYSIFSLLLCTSTNGPHCEKTPRANYLRALHYCPHPIVGRKCCKFSCDKMFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFB7</accession>
    <name>A0A6A6QFB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_469704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFB7"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="104"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="398" mass="43123" checksum="021095301A259158" modified="2020-06-17" version="1" fragment="single">CSCTGGYDKARTTERTYRALWKTVMHSRKAGNLRITTSSAASSPRCSSAYDSDADDEGNMADQPSRPLTVSIPRGFTGPYCPRRPTLSEILANTAPPPWTLSAFMAYLSQNHCLETLEFTMDASRYRKHYSKMMGRNPGSPISPLSDECTYVKMLWQRLLDAYIAPNGPREVNLPSDVRDSLLAQSNPYIPPHPATLDPAVAKIYELMEESVLTPFLNSLCPQTATPGSAYEHDDNSLSRTHTRSYDDRGMYSRNSSPTAQRASAPSSLTSNFLHSRNAAAHGRFASGPPATSSSSAMDTSGSDALTDDSGSASSPSGLDDPMTPPTTPPMSEFSYGNSYYDSQGTTPSPRLGRGDHSGIAGATKDGWKRVSSKLWPKKRSGGALREEDQSPMEGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFE4</accession>
    <name>A0A6A6QFE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_621773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFE4"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="49635" checksum="6DDAEFA3CC00D838" modified="2020-06-17" version="1">MRHFDPVMASEDNALRAASLRDEGNGFYKIGNMVQAVKSYSESTTLAPDDAKPLSNLSAAYFEMGRYTDAVKYAECALRKLPGDEFALRRRCRLRIMKAHIHNKRHSLAWGTMRQLTKDRHFVKDDEWRILNSALEQAHDFSESHDANRALRDEAAYSDMDHDGTCPDFDVPLNGGRPHFSGLVERDELETSLYGLFLKLALPTRCPHRDPTLVYTPFDMTMMFRTVTQLHELEYPAHWLSTVLHNLAHGTMITSARAPPAYPVIRKDSCVIEHNRKRKISVKPFAAEFSTLTTLFTSDLPFGVISPVLPCISNVHRYSIVFPILETTESRDTSLILVFLNTALPSFSRFADLRHALLDDDKGDSSADAKRLREEGVVIVTSLNWTMPERRAEFWMRKDEVERWCDGGNWEVSVWQMDDWTAVSSGVAVNEALSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG55</accession>
    <name>A0A6A6QG55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_552625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG55"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2490986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="471" mass="50749" checksum="070196219A67629A" modified="2020-06-17" version="1">MGQTLSEPVVEKHSDNGEGETLIFGVSSMQGWRISMEDAHAAVLDLHADGAETSKKVAATPLDQRLSFFGVYDGHGGDKVAIYTGEFLHKIVAKQEAFKKGDIEQALKDGFLATDRAILTDPRYEEEVSGCTASVGIISKDKIWVANSGDSRSVLGVKGRAKALSHDHKPQNEGEKARIQAAGGFVDFGRVNGNLALSRAIGDFEFKKSADLPPEQQIVTAFPDVSTHQLCEDDEFLVIACDGIWDCQSSQAVVEFVRRGIVAKQELSAICENMMDNCLASNSDTGGVGCDNMTMIVIGLLQGKTKEQWYKDIAARVAEGDGPCAPKEYAEFRGPGVHHRVDDSPDDLDMDYDHRFRPNSGLGGRIILLGDGTEITSESADSEMFDHDEEDKDLDHQVNPHDSVPIAGSGDSGAAVRSIREATPGPKSTNESANSPSSTGTEKSETVQEPKPISPTDSRLPEKIVEGVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGR4</accession>
    <name>A0A6A6QGR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_596968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGR4"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="47029" checksum="9F22E5670F9F7ABA" modified="2020-06-17" version="1">MPGATPPLLRVAIVGGGPGGLSSAIALSKLENVEVTIYEQARELREIGAGIQIGYNCWKVLELLGAEADVKGHVQETILQRNGLNGDVLGERTSFAVEPRYRGQRVRRTRLQAALIAKVPPGVIKLRKRLASLQNIEGGGTRLVFEDGEEVVADLVIGGDGIRSAVRANVFPEHAIKFTGRTIWRVIIPKSLIVDIPEMTVSTAWWHGPAGHFYNCLVDDPSETPEDKQMWEIAVHNVVPAATVKEKRFSWGIPATNERVESHFTEYDSRVRKALSRVPEGQWKEFSSFSGPRLEKVVAWDKVVLIGDASHPLTGAFGSGAAFAMQDSWILAQAIDYTRSSSQPLASALATFDSIRSPYYLRMYEHLDQQAKNVQDAKIKHPGQTFEESLDVKVKTFGGGPDNLSWIYGLNIKEVWEDFVKTSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGX2</accession>
    <name>A0A6A6QGX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGX2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="352" mass="38342" checksum="D52A3F73BE236615" modified="2020-06-17" version="1">MVQNKGLIFKNVPNGWPKPGHDLVVEARDFDLDQSLPEGGVVVKNHYLSFDPYQRGRMRAPDTPSYSPPFKLGEPITNRGISTVVSSSTPDFKKGDVVVGNAIIGTEEYSVLTAEHTKLVKKLDNPLGLDPKIFLGALGMPGLTAWSSFYAIGEPKKGESILVSAASGAVGQIVGQLAKHEGLKVYGSVGDDAKLKYILEELGFDGGFNYKKETPGDALARLAPDGIDIYYENVGGVQLEAALNAMKPFGRIIACGMISQYNLPPKEWYGIKNTMMIVAKRVKFQGFIVGDDNMGPKYTKEHQEKLQQWIKDGSFKVKFSETVGIDNAVDGFIGMLEGKNFGKSVMVISEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHK3</accession>
    <name>A0A6A6QHK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_530688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHK3"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025718960" description="Protein kish" evidence="9">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="72" mass="7914" checksum="A33AD5813EE078C1" modified="2020-06-17" version="1">MTALFNFQSLLLVILLLICTSTYLHHVFPGPMDRNKDGVLGVFWKGARIGERLSPYVSVACVIMAASIFIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHS7</accession>
    <name>A0A6A6QHS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ATP synthase subunit beta</fullName>
            <ecNumber evidence="19">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BU16DRAFT_552319</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="19"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHS7"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000005">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="212"/>
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        </location>
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        <location>
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        <location>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    <sequence length="1155" mass="128377" checksum="0BC5712A12AC7032" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIY0</accession>
    <name>A0A6A6QIY0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Heme-dependent catalase</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="377" mass="42660" checksum="A0E927E0F0A0018C" modified="2020-06-17" version="1">MSSITNKLSEGYQAAKRAVSSAPPNDAYMRWDAPGVEEVKPTEEQTTREIAEIMKNMQKHNFDQHRHAFRATHVKTQGIVKGKLIVNSDLPIHLRQGIFAEAGRVYDVAGRFANEPVFLQPDQSPGPRGLSLKIFGVNGEPLEGANESDTTQDFFFNNAPMIELTDIDTCLDIMRLRERHFDDPVTLQAKTALRTDALKQTAPTMLPNTNIISMNFYTQSAFRFGDYYGHIALFPADDEMSKKGSEKVQSNQSREILSEWLREYFTERGAKYEFKIQLGTDPAHHPTEDASVVWQESTAPYQTLGILEFPPQDPLSPARRVFWEDHMSLSPWRGLAAHRPLGSINRLRKAVYQQSQKSRDHLNASTSRQINSVDAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIY3</accession>
    <name>A0A6A6QIY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate associated transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_492786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="659" mass="73510" checksum="1FECCB490ECF8D19" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK03</accession>
    <name>A0A6A6QK03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_110965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="91"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="28"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="352"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="39657" checksum="9A5FFFE8C006CEDC" modified="2020-06-17" version="1">MAPQALGPTVETTAFTLTSISTIVVATRFYCRYYVVGAIKIYDLVMLAALICTWGICTINVYQIRFGTGRHMEDQPSGDPTVLLEGTLKTWYVYQLAYLVDLSLVKFSILVFYRSIAARKVFRYVVDTTIGVVAAFTVAMVFVNAFECPKPSDAWSVEILFQGSGSCIDLHPLYYGQAAFNILSDVVILTLPIPVLMRLQMHKNKRLALVGIFSIGFIAVVASTIRVYALHVWATGTDTPYNAAYILVWSQIEINAAIVSASIPSLKPLFRHTFGGTTRNTTANYYSGRSGGSKPIGSATSAAVALKSLPSSATMTSSHTHKLYPVFGNESDEKLFCKKLTNTKGESDDDVESQRTRDQGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKY6</accession>
    <name>A0A6A6QKY6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
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            <begin position="400"/>
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        <source>
            <dbReference type="EMBL" id="KAF2492696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="563" mass="61785" checksum="98A72A06BF91A25B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLG3</accession>
    <name>A0A6A6QLG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">BU16DRAFT_529187</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="503" mass="57204" checksum="78BD34C87BD7912E" modified="2020-06-17" version="1">MSDATETLAGGLRKLKMTSTARSPTPATSSRYVEETTASTTDSEVCDTTPPDLDPLHPFVGPESFSPDIDFQTCLNSSYSWSPTGEIFATGCQNCGKPNSKACVKCKAVRYCGTECQSKMWRKEHKENCSMSFAARFENVLRYGEPLWYSSIYRMFGFSKATTGGDAERLRQVYLEILDAKELNITTDDILKWHNKRIMKEKVQAACELLLADPDCKPRFSAWFTKNTHILDLETKEHDTHLTAWRGLHLPKVQSQQQYAAITSAWTDTEARCYMLFYKLFYGMAPDVTEETYRLFAFCVCNMTQHPNITDLGKLYIELMKKCNFRQFVEAANNNNKRPEPGNEPALVTLFKSKGLDGPLQGFPHVETVLFSREFHQAVWYLKQYVISKKEDLRPEGFFGYKQLMPEDADETLTAIYYEYLVKKGGDAMALHGASVDDSIYECVHAVLPKLDPKRGELMRNGVKRVRGVETKFCGCVDEIRLSHEDVFHPMIPAEHDLVLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLZ8</accession>
    <name>A0A6A6QLZ8_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_89644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="179" mass="19511" checksum="6801E75FC9566E1A" modified="2020-06-17" version="1">MSYYFSIVGTNDKALYEHEFGTSKQGGDGIARFPTESRHHIQFVSNSSIDIVEEVQWSPTTPTSGGAPMYLKHIDKFQNLYVSGFITGGNVKFLLLTAPAAAPASRSSALASSARASAYPSSSNYNPTAPATEEAVRNFFVDVYDAWVKTIMSPFYMVNDKVTSPVFRGRVAGAAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM17</accession>
    <name>A0A6A6QM17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_100241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM17"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="17047" checksum="63299C8135EE4B93" modified="2020-06-17" version="1">MLIAVGSHRHSMGKHYYFLQSLRHDEILVYPFNDALPARPPSRTLLASAGRTSCGVVRKTALFDCCSSECHCGLRARGCMVPSWGCADLQPAAGMTKPGFSEHYLRLHCHDGNFTDRTDLIIEWFCALSWRNGYVVCSQSSHIIGDTRTDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM27</accession>
    <name>A0A6A6QM27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_100686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM27"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="27695" checksum="126278D9446D90F8" modified="2020-06-17" version="1">MSESGNPDVPQNRKRFVPLENNPEVMSALVHKLGLSEKLAFHDVFSIDDPDLLAFVPRPAYALLLIFPVSDTYENFRVQEDKEKTVYDGSGPNEEVIWYKQTIGNACGLIGLLHGVSNGEARTHIGPESSLEKLIQDAIPLKPAERADLLYESQTLESAHQAAAATGDTAAPAAEEKVDLHYVCFVKSRTNHLWEMDGRRKGPLDRGELGADQDVLSEKALDLGVRSFLKRESEAGGGDLRFSLIVLSPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMK2</accession>
    <name>A0A6A6QMK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_563479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMK2"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="108"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="30243" checksum="CF7F02EBDBE48A66" modified="2020-06-17" version="1">MPRINLASPTPWIQSSIRAFSPARRGFVAPKTLLPTTTYLNSNTPKTAHRSFATTPLLHKKAGKSNMSHARTDSAPPVTEASANTPTDQAYDLSPLESNILKAMEKLTHDLSQLRSGGRFNPDVVEGLRVQLGKGDEKETARVKDLAQVVPKGRVLNVIVGEKEHIKPVSSAIAASPHNLVPQSPHPDSPLSIPVPIPPPTGESRKAALEAAHKAGEVATTAVQDARAAHHKKLRKFQVDKSVRPDDLQKATKKMEEAVKRGVSEVKRIVDGARRVLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN18</accession>
    <name>A0A6A6QN18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_562742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN18"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="261" mass="29197" checksum="8BF007B70BA9458A" modified="2020-06-17" version="1">MASILPHVAPRAFRPAFRTFARPQINVQRPSVPVFRRYISTPTEQPRLRLGSTAPDFTAKTTHGDLNFHDFIGNSWAILFSHPADFTPVCTTELGAFAKLKDEFEKRGVKMIGLSANDLGSHDKWVDDINEVCQTNVQFPIIADADRKVAFLYDMINQDDLDNIAEKGIAFTIRSVFIIDPNKKIRLTMMYPASTGRNTSEVLRVIDSLQTGDKKGIATPINWQAGEDVIVPPSVSTADARKKFGDVKEVKPYLRYTNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN70</accession>
    <name>A0A6A6QN70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN70"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="108" mass="12599" checksum="B756193509D3B71A" modified="2020-06-17" version="1">MLLKKIKSIPKEIVLSFILGLHFLKFSPPSIRPAKKRPRRTKAEREKKEKEKKEKELAEKELAEKALAEKALAEIAKAEKERKEKEIKEKEIKERELADIVIAEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNC2</accession>
    <name>A0A6A6QNC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_528875</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNC2"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
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    </dbReference>
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    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
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        <location>
            <begin position="372"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <position position="55"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="334"/>
        </location>
        <ligand>
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        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="487" mass="53141" checksum="FC4282459A8995BA" modified="2020-06-17" version="1">MAPTPKAYDYIVIGGGSGGSGAARRAAGWYKAKTLLIENGRSGGTCVNVGCVPKKITWYFASVNETLKGAHHYFYDVPADVAFHFDRFKKRRDESIARINGAYESNWKKEGIELVHGTAAFAGPKEVVVDLQDGSGKQVFTAPHILIATGGYPILPEVQGARHGITSDGFFDIETLPRKIGIVGAGYIAVEMAGMLNAIGVETHMFLRGDTFLRSFDPMVQETMTKAYEDAGVVLHKRYPGFDKIERLDKEDVVAGKDIHEKRTEGPSPQKQLKITDKNGEVFECNELLWAIGRAPEINDLGLEKIGVKLTESGHVFADEWQNTSVDGVYALGDVTGKAELTPVAIAAGRMLGNRLFGPPELKGSKLEYNHIPTVVFSHPEVGTIGLTEPQAVEQYGKENIKVYKTKFAAMYFDVFSPEEKAKHPTQYKIICTGPEEKVVGLHILGEGSGEMLQGFGVAIKMGATKADFDRCVAIHPTSAEELVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNQ4</accession>
    <name>A0A6A6QNQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_65653</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2494138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="15720" checksum="81F62A43646F790F" modified="2020-06-17" version="1">MRTRKVICVVLSAAGSIRTRRGGLIPTEACPLARLKSSHNGLSHSCSKWWRGEETIGAFRVARLDKFSVCIARAPLRSTRPGCEGPISRLSFFNLGRRIRRCTTSSRHSLINLLHACFFYPLRTLLVPLTRCYMLYAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP31</accession>
    <name>A0A6A6QP31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025465695" evidence="1">
        <location>
            <begin position="25"/>
            <end position="471"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="471" mass="51761" checksum="4EEDF624E1417896" modified="2020-06-17" version="1">MYRQIYSLGLSILTLLLLLPDTLALKLFPVSHPDDLTGGQHGHQKRQWNHTESLDLQDFETFYWGGYSAGDIVYANLTLYFTGDYENIISMERFAGMLKSVDCSDHMMLEFKDNTSFAYAQRVWNWVNNDVNNTFVMIANYEGCGPAAERQPFTVTNIVYDAQHSKAFLTADQKNWTEIAHTYSLSVGHTPAPPPEKRLALRGDPDFSMNLASSFNRNFFSTTAFGVDMSLDCSNCGTSGSLNVDFDIDVALFKISSAKMTISPKDVAAFLEVSMSESGTLSSAYNWEKTIVSIPIDGIEIAKIVKLGAFLDVDVGFSMAEWEGEAHATMGARMTLPNSAIVVVDLVKSENNQFSGWMPDVVPIPLQVSAKVEGSAEIFAEPKIKLTAKALGKGFEVGLNLKLPDISADFTAMFDSTGVCGGLHTLGVDVNANVGVDLSVQAATAGNEANPFWTQELYVRRNSQHCNYSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPE3</accession>
    <name>A0A6A6QPE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_589205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPE3"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="263" mass="28265" checksum="CE9A66E48FBA9C21" modified="2020-06-17" version="1">MDFPGVALVTGGASGIGKATAIRYAIEGCKRIVIADVNAELLQTTQKEIQEKYPDAKVKAITLDVRSLESVQNMVDEAVAEFGRIDYLANVAGIVKYGNTTILSEEDWDLVLQVNLRGVFFCSKAVIKQMLKQEPLTSKDSPYPARGAIVNVASQAGLKGNGDLPCYSASKHGVVGLSKSDGLKFATEGIRVNALCPGTIETPILGKLPQGDVAKERQEARMREIAMKRVGQSDEMAHCIMFLTSGRSSFVTATYLAADGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQC1</accession>
    <name>A0A6A6QQC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_589150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQC1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="510" mass="56188" checksum="B9D2977320E62F3A" modified="2020-06-17" version="1">MAGRGVSQVAAKAIAGEVRNLGAGGEGREGRADLAGVLAGAGEGAGEGVGVGAGVDEGGALGVLVALGVPVARVALSSTASPNSEAEEEEIAEEEAAFLQEQLTEIKSRLHSNKADFKQLFLEPPEAESEEELEAEEPSAMVAPAWAQEGFDPATIFAGRTPNKYTRAFETSLHALILAIFEDEKADQARNPFMQLVKKELWVKATMRIIASVHPTVLRELVGGSIAHKYYTKDQEVVQVVDLLESRRGKHPSLYMRVLVNERTGHGPTARDFEGIVHWIRQYTKAGQEGLNIARRMDRAMPNNPHSEQELAEGWRRYLSCDTLEGNKQRRQVKAEWCDNLEARLKAVPEDQKDLPLWPPLQYIGYARNAEARQANHDKHVGSNYLMMMGGGFCHHPPGVNNSSIRDVSEQKWAELHEWTLKFTPYLANLATEAVRFEAYLTQRKAAAVQARDRAQKGMEDSLRLYHAKLLENVASANFQLEVLMQTDLVPRRTPGTGSSRTLSGESAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR60</accession>
    <name>A0A6A6QR60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_419312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR60"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="34304" checksum="2B9AB144EFD3A4D4" modified="2020-06-17" version="1" fragment="single">FIKRQFISYPPIPTTSFSGKTAIVTGSNVGLGLEACRYLVRLGASQVLIACRNTEKGEAAAKDIQASTSCSPGTIKVWQLDMSSYASVQAFAERATAELPRLDILLLNAGLATMKFRMAEGLEETINTNVVSLSLLAFLLHPKLHDTAVKYDTETHLTATGSELYEVAKFAERAAPEGQIFATLSDQSEANMRDRYNTSKLLLIFVMKQLAAIAPLGPSKVIVNCVGPGFCQSELHRDYTNAALRLLIRLLARPTEVGSRTLVYGAGAGPDTHGQYLPDCKITPTKGLASGEAGSKLQARIWLELKQKLEVVSPGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRE2</accession>
    <name>A0A6A6QRE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_46402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRE2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025450858" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11625" checksum="85AEC95F5A47857D" modified="2020-06-17" version="1">MLRASFLAHLGFFKSVYLHMLFTCFSPLSTHSQESLDQGPSTSRRLPISALAQSRICLCLTTARFRGFRCTKQPCSPAIWVRERRRVISGKEARVESEAMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS26</accession>
    <name>A0A6A6QS26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_386540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    <sequence length="329" mass="36994" checksum="F2CB33AC83EF042D" modified="2020-06-17" version="1">MKISQLYTYPIKSLRPTAVTETVVTKYGFPYDRKYILLRVHPDRYEPMQVSKVTAMTLFFTRIIFPEEDESGAGSIIVTFKPPSGEEKQLSVPLLPDVTGLDTVEVSMYRSGLDGYKMQESFNKWFSDCFGYDVILVHVGNNTRPSLFGEEEIEKPTGSWFSSITSIVPGLAPSKQESDQLTFTDCASYLVVSQKSLEDVSSRLPEGEEMDITKFRPNVVVEGAGSAWEEDLWGAVRLGDAEISLKHNCGRCASINVDYSTGKPGTGEAGTILKKLQKDRRVDKGIKYTPVFGRYGFLEPKDEAKRVRIGDEVFVTKRNSEPTTWNWKM</sequence>
</entry>
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                <person name="Gonzalez J."/>
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        <source>
            <dbReference type="EMBL" id="KAF2495195.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="19234" checksum="DF659805BA99712B" modified="2020-06-17" version="1">MMAPPPMPFGVPLPQPPHGGHIPPPWVNHNLGGPAPIIPNEPQEGSNIHFPGGRMPGYNILFSKEYCCVNMFIMDTPPWDEDAKTDRAETQKYHVDCNWNMKQVMDRLRSGQDCAAWAITEVVEKGDGKWARGSTFVYTSERAALPLTLVGWTKNRRDGDKGAIWVWMHKP</sequence>
</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="401" mass="43504" checksum="486B4602DB40EC01" modified="2020-06-17" version="1">METYSWYNISVVCFAAFGSLFTGYSLAVFAFTIGQPTFYTSLGLVSDPTSPGYSHTNDIIGAANGVFFGTGFFGCFLAGWAGNRFGRINGFRIAAVTGIIGGALQCGSQSPAMFLVARAVAGLAAGHTMAAMPTYFTEVSPPHSRGLITVPESPRFLVQRDNQEKAFEILVRLHSDPRDANNTFAHQELQEIVERGQAEKELIRVDGRWRLFTKKTNFRRLILACMVMIGGQNIGPLVINNYNVRLYGSLGLGATKSLLLSAVYNTIGLIFASVGASISDRLGRRKAMVTGYVAVTCVFATLTGMIAQYNNTPSKGWAAAAVTMVYLYVVCYNSFIDLNQFTIATEIFPTHLRNQASAIAIKMDLAMTGIDHTQNPDHDLKGVNDPESNHIEALGEVKNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTD2</accession>
    <name>A0A6A6QTD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_527444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTD2"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="612"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="821" mass="92987" checksum="E337270625F8D8D5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTJ2</accession>
    <name>A0A6A6QTJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_385634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTJ2"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="463"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
    </evidence>
    <sequence length="798" mass="85444" checksum="CAFCC30F3EC0B20D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTV7</accession>
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        <name evidence="20" type="ORF">BU16DRAFT_549558</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="20">CBS 269.34</strain>
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        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <comment type="similarity">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="373"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="527"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="582"/>
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        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 15">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="436"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2495841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="619" mass="68527" checksum="17AAA8C28C3960D4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUG8</accession>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_617309</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
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    </reference>
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        <subcellularLocation>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="693" mass="76750" checksum="7BAEC02178FD31E5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUR2</accession>
    <name>A0A6A6QUR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_560793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="364"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="51379" checksum="8C171629286A5D36" modified="2020-06-17" version="1">MAEVSLTTLAESNREQTRELFGAEYNTVPDTNDLAHKSRVATRVYQEYGAVAELPAALEAKMQAATAQRKRRKVTEEDQPSDPKLRQIVGTLAESSSAERTSQALTVRPRGNGAAPNANGPTPQRNTPSSALVRKDTVKQVKPEWHAPWKVFRVISGHMGWVRSVAMDPDNKFFVTGAADRTIKLWDLASGTLKLTLTGHISAVRGLAISPRHPYLFSCGEDKTVKCWDLETNKVIRHYHGHLSGVYALDLHPTLDVLATGGRDASVRIWDMRTRANIHVLSGHKGTCAAVKCQEADPQIISGSLDSTIRMYDLAAGKTMGVLTHHKKGVRALATHPKEFTFASGSSQSIKQWKCPEGAFMQNFEGHNAIVNTLSVNEDNVLFSGGDDGTTAFFDWKTGHKFQSVNSVAQPGSLDAEAGIMCSTFDRTGLRLITGESDKTIKIWKQDESATEDTNPLDWKPTLGRQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV65</accession>
    <name>A0A6A6QV65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BU16DRAFT_526542</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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            <end position="288"/>
        </location>
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            <end position="404"/>
        </location>
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        <location>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="626" mass="65681" checksum="0459C2EA7E6A2CE3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ74</accession>
    <name>A0A6A6QZ74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_459721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ74"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24210" checksum="90065FF86B946B9D" modified="2020-06-17" version="1">MSRAPPTIDLLLTLVPDRPSSVLNSLYSYPNLASTADAHGYSLLHAAASYSHMELLKALIQRYNVSPNLLDEDGETALFVAETVEVAQTLVQLGTRPELRNSDGKTAQEKMVEEGEFAEVAVFLGGLGEGGAGEQAAAGVGEEEEEVRAPPPLPRGVQINLGTMPAGEEEEAPDPEFRRRIEELAASEDFQGEEGQRRLRELVTEAVTGISAEGGDRQVRRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ78</accession>
    <name>A0A6A6QZ78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_456526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2497402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="635" mass="72406" checksum="8350F85A34F9AF59" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ82</accession>
    <name>A0A6A6QZ82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_457560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ82"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="368" mass="43106" checksum="1DE62B8449B4AEB2" modified="2020-06-17" version="1" fragment="single">HGVSRVAGSQTRSDQAREKELQHITRYNELVELIAETQYTVEVLNLTTKLLTENPEYYTIWNHRRRVLQHLFPTQAESASLSSDSHQTTLDLITADLSLTTSLLRQYPKCYWLWNHRYWALQVGEARLQVAAARKLWQGELQLVTIMLGADSRNFHAWSYRRFVVGELERIPAQPDEAIHSKQSQSMTEAEFAYTTKMIKANLSNFSAWHNRSKLIPKLLDERDSDDAERRHMLDNEFALIHEAFLDPFDQSIWYYHQFLMGTLSSRNSRESAIILDLTDNDQKRYCEQEINFIKEILEDEEECKWVYEVLLQYSTSFPSLKGNESVITSDDLREWLSKLRGLDPLRNGRWTDIERTLDLQSKGLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZZ1</accession>
    <name>A0A6A6QZZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZZ1"/>
    <dbReference type="OrthoDB" id="10399749at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="493" mass="55778" checksum="EE18C2E3CD53DB2E" modified="2020-06-17" version="1">MSLPWWWLVWQYYENDTIILRTPTGELHWKDGEWQHGDYPPQDLGRHYFPYERTRSAPPADNVQIGGFGSWPEDSRPTQPYLRSIMQTKLPRLPAQCQQLSSARWPRTANLADPKASLQKEQVDRFRGGMLPPEACDVEAQASLGDRFGKGLTFSVAVSMNDTKNIYDQIQENFADVFGHWTWIFPGYSHLRPTMPTASDFGALGQLRRSIVETLSTSSSSWSPSAESVLSGLPGRFIDSLEHGIEIRPSRPQSVVPSPHRDEDHSFYEKIPQIPNMSPRSTRKLFKGFRRLRSDDLEPITFEKRTLDTNTKLNQSSVITDGLQKLASSPTNSTVDFRSLHRVRGFINLRDGRYPSISGTITSGDSVPFIRSRFSSARDSVAVNYDSSFPSSFRSISYSSSSHGASSRFSNHTNEPRTHEPSNENGLGYFVDRWQARSPLASLTLLNEEPNLEIGANVDLEAQAMPPMRGKKPLHKKVIRAMKKTAKTLFRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R035</accession>
    <name>A0A6A6R035_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_327406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R035"/>
    <dbReference type="OrthoDB" id="5278722at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44999" checksum="3A014D61D64DE089" modified="2020-06-17" version="1">MRFLTRLHAISAMVILSLFYFGWILPSLHIKTRIQKAWKGHARQLVVFGDDWSDIGEYRISPPKAASVPVRDEGQGQLWTEVLCKELVCDYIDNFARSSIAGDNSSMGSLVDNDIYANATSLNETSPNLVPDFKKQVQQWINFEKQKRLMPLRHGKGEWTIFTVQFGVWDLLRYASLGKKQATFAIDRSIEELFHNLNTIAEHKSEPIKVVLPVLFDVTFLPRFANLRSDHSADFAYDQHFAVFLLGYWNSVLSRAATHWTSGEIVMPDVNRILVNEVRARQLYTMGITDASGAGTQKPLFKEVETPCLSASVPQDGDLQGAVPLRCAEPTGHLFWDDMHLGGAAHTLIGKNAAELVNGNETVNMDALEKEKNSDNKASVFSDLRKMRKDFRLKFPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Q7</accession>
    <name>A0A6A6R0Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_290771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Q7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17414" checksum="4BABD982EE36C3C1" modified="2020-06-17" version="1">MEYKTCSLMCTLHFNSTVHRNIKNPSRVDSMVVTGHSIVSRVLLEPFQIHTIPLPPLLFRRICLACSLSFFIPFPLTKSIRILSQWKHSATPSQFSKGIIVVITSAESNRVTPIVEKVMCVNCHNFLGHVLFLKSGVVEDFLGVCAIRDRPAHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R131</accession>
    <name>A0A6A6R131_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_457176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R131"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025366925" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2497543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="440" mass="46759" checksum="29D99BDA482D4ED0" modified="2020-06-17" version="1">MKFIPVLSLTAVAVAQQAAYGQCGGNGWSGGTTCVSGYYCRFSSDYYSQCVPGTGGHPFLQKTLVLRLTFQASGGATTLSTVVGVGTSTTPPTTGATGTISKASGTKFTIDGVTKYFAGTNAYWIGFLTNNADVDTVMSHLQSSGLKILRVWGFNDVTSVPGSGTVYYQSFSGSSATINTGADGLQRLDYVVQSAAAHGIKLIINFVNNWTDYGGMAAYMKACGGSTNKDWYQSSSCQALYKNYIKAVVSRYSSSPAIFAWELANEPRCNGCDTSILTNWIKTTSAYIKSLDSTHMVTVGDEGFGVSGGDGSYPYTSGEGWDWDTNLAISTIDFGTFHLYPSSWGTSNDWGNGWIQAHAAACVKANKPCLLEEYGVSSDHCTIEGAWQKTSLSTTGMAADLFWDEGDQLTSGKTSDDGNTIFYGTSDWTCLVTNHVSAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2C5</accession>
    <name>A0A6A6R2C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_524938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="9907" checksum="4F327A09DA724F5C" modified="2020-06-17" version="1">MSVEAVATSVAAPAAKPAVQGIRINGKQWHEKRAPLRKNAGLTSYQKRAEDTKVLAAIKAKEKEMKDEKEAERLVGLHYGRPTRTGLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R343</accession>
    <name>A0A6A6R343_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_309090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R343"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="25814" checksum="2EAFC71277B7BE79" modified="2020-06-17" version="1">MDNLKGLQAGLEKIVLDPKYHDVLTLVKGIRNGIVYGSKVRFPHALVMIFLFRSGTLRQKTLLVLRATRMHARNLGLFALVYKSSMLFLRHTSPTGKERHWDAFLAGLVGGYTVFGRTIHNSVSQQIVIYVFARVVLAIAKNLVEPKGKGRIAGGGGGWGLIGDEKVRREVVRQGWPVFASVSWAAVMYMFRWHPETVQPSLRNSMHYIYVQSDHWDSLRNFVWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3B6</accession>
    <name>A0A6A6R3B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_578835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3B6"/>
    <dbReference type="OrthoDB" id="5101370at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025471186" evidence="3">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        </source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="743" mass="84223" checksum="51B1E74DD4B3F302" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9R4</accession>
    <name>A0A6A6R9R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_613295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9R4"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="96"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="44310" checksum="7C662104941ACBD5" modified="2020-06-17" version="1">MAPALTASAPAPPHTLSSPSTAPKSIFPDGIKTSGQHPPLYDLLQPYSAFPKTITGPTVWDAADYASNPERWTHPFSASEIAEISAAADAFIASGTPLTGISQSNFTLPEFSTFLKSLRHELLNGKGFLLFKGFPVDEWGLRKSAVAYMGLGTYLGYFVSQNGRGHVLGHVKDLGEDSSQIDKVRIYRTNARQFFHADDSDLVGLLCVAKALEGGESDLVSSHHVWNVLQQEHPDVAEELVKPQWYFDRKGETSKGEEEWIKTSVFYLEKGENPRVYSKWDPYYVKSLTRFSDAGRIPPLSPAQLRAAQILEDTCVRLSLHMILDIGDIQFLSNEHVLHARTAYKDYPPPAPRRHLMRLWLSTPEAEGGWKLPFHDSQEKKRGGIQVNDTPPVAPTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAD4</accession>
    <name>A0A6A6RAD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_501132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAD4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="490" mass="55112" checksum="E47F785DA37A35A8" modified="2020-06-17" version="1">MMSLLGPLDKRLLVRRCKACQRRKIKCSMPTPCTYCVRTCQPCEPASGAGAGREPRSKAVVFTLPQTGAKPIRKGGKTLDQHVLLSPTVYHVDLWPDSTDQHVSHFFDVFLAANDFSGTSWRSLPISLSEMIADSSALKDVAIALAALDCSRRPHSAPTAERGVSLRQTALSSYSRALQEVRVELSTPNQLVARESTVWVTFFLGIFELMLESNEKNWEKHFLYGTSHLLQVQGPKCCGTGRGRERFLALRIFEISRALIYQNTTFLAEPEWLELAQQLKEEDREGWYPKEAMYDLMLSCSVLCTRATYYADAVEAASETLDTSDGFAVITEGLYLRRCLSDWYHQIECRLPTARDPSTPLQTNMELLIALIYYHALSIFLSGCFDYRLSCFPAPPASLPILTRTQVERHLASILSLTELALNKTWLTGVAFLFPLRVAAARAWSAADQNEVVQRLRSVRSKGFSITNLFEEEVNCLWEEGGMPDGWKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAH7</accession>
    <name>A0A6A6RAH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">BU16DRAFT_577677</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAH7"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
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    </dbReference>
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    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="107"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <begin position="191"/>
            <end position="195"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <begin position="245"/>
            <end position="248"/>
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        <ligand>
            <name>GTP</name>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2501551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="807" mass="89726" checksum="52495056EE19D9AB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAI8</accession>
    <name>A0A6A6RAI8_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_450423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 269.34</strain>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="140"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="298"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="327"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="435"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="489"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="712"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2501561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="788" mass="87705" checksum="4CA5231315481054" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB50</accession>
    <name>A0A6A6RB50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase MuDR plant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_577260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB50"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004332">
        <property type="entry name" value="Transposase_MuDR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03108">
        <property type="entry name" value="DBD_Tnp_Mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase MuDR plant" evidence="3">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="409" mass="45149" checksum="15BB4B8299F2A34D" modified="2020-06-17" version="1">MASHDSMNFDPALENNDDSPDDDSEPSPNNTNHGDAPPPDLDVPVPVEGSSYADWEALRYAINAWALRDKFKTRIHKKDSTRAVYHCKYETKTNPPCTWRIRANVSRPSSSTPSQHPPSVVVTVVQPFHTCNPDEHVEDDKYWRRGVQFTQRWVRDSLARCGFQVSVDTAPAEIVQVIKERFGEDIEEKLAKKAKTSLLVMRGDIQPPPRGKTQRAPGVNRGGRPSKAMLEERKRVAEAEAHMQRRRAIERERREREGLPPLNDHELMLFVEGEGHGQSQAQGAMAMAMQAQQNPAVVTGGEDFVFESGERILGPVQQYLVDAARAGTTDPAPAFHSHSIPSGARSVAPMLANGSSRPCETCSGTGVVSVPGRAGGRSQEDDELNVLKNQVAMLAKQIALMQNRRARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB62</accession>
    <name>A0A6A6RB62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_522603</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB62"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="177"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2501694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="660" mass="71647" checksum="AE9E03117B4E6FB4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBN0</accession>
    <name>A0A6A6RBN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,3,6,8-tetra-HN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_554300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBN0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="268" mass="28402" checksum="B10709B170B3ED35" modified="2020-06-17" version="1">MVINVPTASLEGKVALITGAGRGIGRGCAIELGKRGASVVVNYVSSKGPAEEVVKIIEGFNNGAKAISIQADVSKVSEITRLFEEAKKHFGKLDIVMSNSGTESWDKTEEVTEEKYDHVFNLNARAQFFVGQAAYKYIEDNGRVILMSSIAAGLLGVKDHALYNASKMAVIGMIKAFATDFGKRGITVNGVAPGGIKSDMFTQNAWHYIPGGTPDIPAATIEQMMSDHCPLGRCATPEDVARVVGFLSSEDGGWVNGQVITISGGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCA3</accession>
    <name>A0A6A6RCA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_197055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="319" mass="34441" checksum="B9D2816213188818" modified="2020-06-17" version="1">MPFRDPVAALLAEKTTIILDGALATELEARGLDISSPVWSAGALVTHPSLIRDIHFYYYRAGADVAITCSYQATPQGFREHLGLDEDTSIALIKKSVDLAKQAREDALFNVPPQYARKLLVAGSVGPYGAYLANGSEYTGDYSVSTKDMKDFHRGRIQALVDAGVDLLACETLPKLSEASALVELLSEEFPEVAAWMSFSLRPNDPSHISDGTPVEDVLKALNSSPQVVAVGMNCIPTNLVVPALKFWKNYTSKPLLCYPNSGERFDAVTKTWEGKLSESAVVADLVIPGRRHGAKLIGGCCRTNATDIENIVAALNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCC9</accession>
    <name>A0A6A6RCC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_576252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCC9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="569" mass="62696" checksum="3FF8EC3967B25521" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCE8</accession>
    <name>A0A6A6RCE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCE8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="111" mass="11927" checksum="A42892F0040040E2" modified="2020-06-17" version="1">MPTKRLYTMDQWILILIRGAIEGFAAAQRNPHLPSAPSAIPPAHRGGSPQPRDPPQNPDDVPNSPKPHTASTTPAPRLGWGLPSSPVANLYQASGLLPYIQQHSTNLQING</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCK6</accession>
    <name>A0A6A6RCK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_576314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCK6"/>
    <dbReference type="OrthoDB" id="3799394at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025692648" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15404" checksum="4092E4AAF266966C" modified="2020-06-17" version="1">MKNLVTFTVFLVLSLATPTPVDKSAVCYCEPPICALELITECKCKNAAALSCYTDYLAQGIACPSPTPSPCGAILIRTKFPIPTSTATAIHCGGLLGLPCPEGFICIDDTSDSCDHRNGGTGCNDVCVYRETTGKIPCGGFEGVACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCP3</accession>
    <name>A0A6A6RCP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_521252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCP3"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2502535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="401" mass="44265" checksum="748C9E14FC789AD8" modified="2020-06-17" version="1">MRLLKQQIDKKNGSGFAVLLPEEPEDMWHAYNLIQPNDFLRARAMRRITKESESGSVTSVRVPIDLTIMVSSTDFDVGSGQLHVAGKVSAENEHVKLGSFHTLDLELQRKFTLEKADGWDSVAIEMLKEAVDTSKRAQVYAVVMQEGLANVCLITEHQTILRQKVEVAIPRKRKGGIDGHDKGLDRFFTTLLRTLLNHIDLPSQTPPYTPVLLASPGFLASAFQTYIKTTATATTNKPLLALLPSILIAHSSSGHQHALTEVLSSPAVLAKLADTKYARETALMDKFFELLRKDDGRAWYGPKEVEQAVEKGAVGRGGGVLLISNALFRAQNVAERKRWVSLVDRVKDVEGGEVRVLSSLHESGKRLESLGNVAAILTFPLEDLDEDDEEDGGRAEGEMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCQ6</accession>
    <name>A0A6A6RCQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_522485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCQ6"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="280" mass="29598" checksum="3098D4B8E9ABC3B9" modified="2020-06-17" version="1">MPHILLIGGHGKIAQLLTPLLLAKSWSVTSLIRAQEQVSAIEKLGAGKPGKLSVLVDSIEEVKSEADAKGVIEKAGKSEQVDWVVWSAGAGGRGGPSRTLAVDRDAAIAFTRASIANPHITKFLTVSYIASRRNRPSWWSDADWESAQNVNNNVLATYFQAKVAADEVLTAGAKLRYDDEAKKGVEEAKRFHGISLRPGNLTDKPAGGVTIGKVPSRGTTSRASVAEVVAKVLDTPGAKGWLDVLDGDDSVDAAVEKAVKEGIDSVEGEDLAAQKERAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD51</accession>
    <name>A0A6A6RD51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase,short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_587486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD51"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF11">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="305" mass="32037" checksum="934EAC2839583361" modified="2020-06-17" version="1">MTDLNIKKSDLVGLKGKVVVITVRVCSHSCYTTGGSSGIGLATAQLLLSLGAQVVVGDTNAPPEALHATFLKTDVRVWADQVALFNKAIETHGVIDHVFANAGVAKTTSLIDDELDSNGNLKAPDLITYNVNLIGCMYTTRLGVFHLKKNPKGGSIVVTGSACSYQGFSVVDYCTAKHGVLGLVRSVKAQLPPALNIRINCLAPEWTDTGLVKSTFFRSLDVPVQGPEVVALSAALCMADGARNGQLILSKEGKFKELEGGYMPWLVTQTGGESVSIEAALAKLQLKIKEVAEAPDAEAGAEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD81</accession>
    <name>A0A6A6RD81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_521487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD81"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="121" mass="12780" checksum="FEC6278249607323" modified="2020-06-17" version="1">MPSKQEIIDERKANLPLPEQPPQASDWNSLDERNVNVGSGGVSADISSSDSLRGPATADSDVRVDGEEYKSNTAGRGAGREGQDNLGGLPNDAVSRDAKNKSATVDTTGKDYGNTHQPALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD88</accession>
    <name>A0A6A6RD88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_521102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD88"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="51069" checksum="7FE870D19579B779" modified="2020-06-17" version="1">MSEKTHRTTRIVSVVAATTIALACGTNYAYSAWAPQFADRLQLSAVQSNIIGTAANLGMYASGIPMGIVTDKRGPRPSALIGSVALAAGYFPIRLAYDRGAMSVALITFCSFLTGVGSCAAFQASLKVSALNWPHHRGTATAFPLAAFGLSAFFYTIVSRFAFAGNTSSLLLFLSLGTSCLVFVSVPFLAVVDHTTRYVVLPTTEDFSHPTRRDSNQLHRTKSGGSKHSASILPRQEPNITGLALLPRIDFWNLWMLCALLTGVGLMTINNIGNDAQALWAHYDDTASKDFIAKRQLMHVSIISFLSFLGRLASGVGSDVLVKRLHMSRFWCVLTSAAIFALAQFCGARIENPNHLWAVSGLTGLAYGALFGVFPALVVDAFGVGGFSVNWGFMTLAPVVSGNVFNIWYGAIYDAHSDVGRDGDRACAEGLACYRSAYWVTLVSSVLGILVCLWCIKHEHSAKSKDIQDDHREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDD6</accession>
    <name>A0A6A6RDD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDD6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="58" mass="6812" checksum="038057BF28EE7E93" modified="2020-06-17" version="1">MSTSVSRPRSSNTTPDAGATRTPTVPKERLRTRKKKEKKEKKEKKEKKEKKEKKEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REJ0</accession>
    <name>A0A6A6REJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </feature>
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        <location>
            <begin position="30"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57505" checksum="865FBD440CFCB9B4" modified="2020-06-17" version="1">MSFSNTGGGKRAEAFDKTDISTAAPRKRIKNENERAEEKTPCHGGATLLDFPAEIIDHIAQFLPRNSFLALRATCTDLQQKTDYHFSRRHLKEKHVVLKFNRSRAGLLALVELASNASFANCVQKVVIGMDCGYYPYAVHRITPHSYRYNTGKLGWPAYFLDPPLEQSRSDGGVAVAMSVLFASLAALPSLEVLEFVDAPDNAEGTLLPAQDILHSQRAKPFVDLSWCNRCKKPSVFGQCVHKTMLCKAVAHMTEFRVDLPDHTHALGLSSLLPDIKATWPGEHGRRLELDLLREIHFSGEHDSLYQYDRYYWSLWQDLFNYSPQLEHLNLNGSMIPSSRLWDQCWSSVNLPSGLLTSLSLHGLNISSNKLAALFQQNGASLHHVSLDGVMLTRTTFPYQFPPIDVFLNVLAQYAEKLKYIFIRAIFHKNRPYLFGDETSSERLQAYLSHESKRVRDENFSIWRFSGPNAQATSNSRDLTGWKFEGEEVEAGLVFLRDNARLAPDNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2503149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2503149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="185" mass="19966" checksum="5DA7D5CEA63AB908" modified="2020-06-17" version="1">MRAPHTGERPRKHPRAIGCLQRCATDILLFGVKAHGILAALSLHSDSVTCIGTASLRLGAGCSLLCLSFSLLRLLYLVSFRITSSYHGVRTARGSAARADAQEEQAAEAAPGLGIGFLSITRRFSRFVLIFATLRPSSIEGSAYLIIRSYFLVDLNLITAGDFAAFFPSNHCIGQGYYGCIRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1 2">Belongs to the SF3B5 family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="93" mass="10633" checksum="604944F417F0D056" modified="2020-06-17" version="1">MADKLRAQQQLEALQARYVGTGHADTTKFEWTSNIARDTYSSYVGHPPVLQYLSLGLGQPREKVRAQMIDKMIQPVGKPPEVCWNYPVWRDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="60"/>
        </location>
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        <location>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="22365" checksum="099F44BC83927490" modified="2020-06-17" version="1">MGDSESTAFLSTRAALTSSPSYGLGTPSQLTPNTRSEAEAALTANSQAQTDSAAPTTPLPDAAARFEAIHALAASKSGYMAASTDGAGEKTQGRDGADDEAKLAYRRAPARTSSSNYAEALVGAGMSPVPHTSAVYEEPGRMSPDSIAAGKGVVPLKTGVGEGQAEAVKRAKPVGLKLGDLGRKQSWSPEDFKHVYSERLMVKGNEDPGYSSTVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFJ6"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="34772" checksum="29D7E0F1A026F410" modified="2020-06-17" version="1">MSNSTPKSVSVSTEKTFTSYTKDQGATYAQNRHGYHPSVYKTIIDHHASTGGQFNSLLDVGCGPGTAVRALAPHFAHAIGLDPSEGMIKHARELLGVTSISEPVRFEISTAEDLGWHLSPPIEDASVDLITASTAAHWFDMARFWPSAARILKPGGTVALWAGGPLTIHPTMPNAAAIQAIFDEIEERDMKPFLLPGNLLTRSLYVGLPLPWTLKSPVPDFDEATFFRKEWSPGNGEEFFADGGQPVGLDVMEKGMGTMSPIQRWRDAHPDAVGTERDILRIIRREIERALHEAGVEKGKEVLKGSPRGVLLMIKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RH87</accession>
    <name>A0A6A6RH87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RH87"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025429499" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="24692" checksum="1777AA6C4F1E4ACB" modified="2020-06-17" version="1">MFPKAIISALVAICLLTTQTASSPLHHLEPRNDGSQVLVMQQPDNSLPGPTGLVLKYILLGIGTQNYTCAAPGSTAAPGTTGATATLYDLGTKLISDPLAKWKINTLSGLALSMSSYPQVLSAFLSASGYNIVVGKHFFSSGGVPTFALQNIQTKPFPQVNGKKNATMTAPAYSCPGKSNEGAVPWLQLIDAGGSQGGVNTVYRLETAGGSAPATCADVKTTTFEVAYAAQYWIYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7I7</accession>
    <name>A0A6A6Q7I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_474252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7I7"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF238">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2488275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="141" mass="15371" checksum="4E93DB542A41D4F1" modified="2020-06-17" version="1">MGSDFEAKPIASSTAAASSGYGLATAPVADLDPPPQQPVVKKGRTNTPWTAKEEQTLKQMRDAGNSWSEIAKTFPHRTEGSVKKHWYKDMHYAEFGEDESAALLAAIKEYDANKWKVIGTKVGKPAKACESYAKEHFGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8E4</accession>
    <name>A0A6A6Q8E4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_473731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8E4"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2488585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="321" mass="34238" checksum="B4395327E7B1463E" modified="2020-06-17" version="1">MPSSLRTRNFNIDRYLNRLVPPSPLHNMPYPIAHFLGYRKTPPKDVGNILGAIFAFIGAFVGLLAIAGLFNYTSINNLNGPVLIASFGASAILEYNTLASPLAQPRNTLLGHALSATIGVGITKLFALSSLSHSFSNSLAFVPAALACALSSAAMLLTNTVHPPGGASAVLAATLPEIVDMGWAFVGLVTLGSAVMLAVGLVTNNLMRRFPVYWWTPDDLRGEKGKERDVEKAEEEGAKVTVTRDGMQVPDWLVLDVEEMVLLERFGERLRRGKGVVDGARRASGASSAQCTVVSSKEDGGSWGLAESSSEDRGLRGKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9M5</accession>
    <name>A0A6A6Q9M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_519690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9M5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF6">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="513"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="670" mass="75317" checksum="DD1C98EF6ADFAD36" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA39</accession>
    <name>A0A6A6QA39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_544611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA39"/>
    <dbReference type="OrthoDB" id="10428767at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025635720" evidence="1">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="305" mass="34897" checksum="02DB315F53FC19F8" modified="2020-06-17" version="1">MLKMLSWDAGPCGVLLAHCLVMAETSLANFTPQATSLDRYSKIARTLNFLKSHTHTAVQLTMSQTIDFDTEAARYLHNLLHTVLLEITPKKITAAWAERLPVIQDGHQHTADVIRVYEEEGEEWQMPADIDAEAARALLESNQCDDAPVILGSIIAALYGIRNVEVLTLRVYPRLYTLNPGDRLSPRRVHTVLRIGDKVLDLTAGQFGFKWLLGPEREYRDEFVVEGPPEVCIPLQEAWEDMPSRDGELNAVYNSLRIRLKREQDSWLRVNGETLRGVVMGEDEEKRRDLWEKLRVIAERVWQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAK5</accession>
    <name>A0A6A6QAK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_553822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAK5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="37886" checksum="8D613F50D94D8658" modified="2020-06-17" version="1">MRACQIIEYNKTHQIRQIPIPSTSSLRPHELLLKIAVSSLCHSDLEYQSGTLSNTLPVTASHEGTGTVIAAGSAATAFSIGDRIMAGQTFDRCGECDDCRGPEAYQHYCSHQGPMMSTQRNGAFQEYLVVDARQATRIPEGMSFLTAAPLACAGVTVWRGILNAEVPKGGWIGIVGSGGGLGHLGVQFARARGLRVVGVDARDEGLDLTDQVGADLVVDARLGKEEVVRRVMEATEGRGVDGTVTLSDAKSAAAMGCAITRKHGTMVYIPVGHALEIPFEEVIFRDVRIKGSFLCSPREATDMLECVVQHGIKVQSTIFHGLEEVPKAVEQLRAGTYQGKGVIVVDEEAAKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAS4</accession>
    <name>A0A6A6QAS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_597867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAS4"/>
    <dbReference type="OrthoDB" id="10373926at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="213" mass="23835" checksum="193C81A6C2F5310F" modified="2020-06-17" version="1">MEQHTVYTSQPPTTTPTTQTKSHEPIYSSYPAALLHAVTSANRNARLARIARIARQRANEGYDYRPVFSFNESYTPPSPSRAYVVTHTKTVPKGKQEFDDYVGMYERIEAANEKCLEYLKEAHSGVVENAEFEEFGRDEDVREEESGGSGEEGQGSRKTKKIAEKGTKERTDSAKGLGQVSWMLDKGGALAMWFTEERTGAVFRVRVDKGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAT6</accession>
    <name>A0A6A6QAT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_471747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAT6"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9236" checksum="0F4E911CD088C8EC" modified="2020-06-17" version="1" fragment="single">DHCNAAQIEQPRWQDVSDRRGGRTAWSSVVVVGEKQFPARYWYDGNYVEQAREDAAECALQFYGQTPATTNYQRAYGQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB30</accession>
    <name>A0A6A6QB30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_520433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB30"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025378175" evidence="1">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="375" mass="39849" checksum="5A8A44285F9E5D25" modified="2020-06-17" version="1">MVLFSKSLIAFAATVFASGILAHPGHDPSEEIAQQAAYFATGGKRSLVHCSEQLKARGHEERLIARRRFMLEKLRKKKRSLETRDFTSVLNTDHHSTLDVSPESPENVIFAGNNSCILSPDVTEGPYYVSGELVRKNVTEDEVGVPLTFDVQVININTCEPMPGVLLEIWHCNSTGVYGGVVANGNGNILDLANINKTAFRGIQPSDADGVLSFDTIVPGHYTGRTPHIHVLAHLNATLLPNATVSGGTISHVGQLFFDQTLYDDVRTVSPYSENTQALTTNAEDSIMGEEAATSDPVLEYVYLGDSVDEGVFGWIAFGVDPSVNKTVSAAASYGIGGGHANNNTGDGMGGGGGGGPATPASPGRICRSHTCYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBP0</accession>
    <name>A0A6A6QBP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucoanthocyanidin dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_531777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBP0"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="39034" checksum="F287D3D5F3284E08" modified="2020-06-17" version="1">MTAKTTYRERTIPRISLSDFENNIDAITTQLCDASENVGFFAIVDHGISIQEIEDMFAQSQSFFALPDDVKATVPWSPNNVGWEKNAQIRPSTGAPDTKESYQLQFGSYMNDTWISRSHLPEFKEKSLAFMHRVRQVSERLMICFARGLGFPDDYFIKLHDVSRENVQSVLRLLHYFELPEVSDGKVYHRAGAHADWGFLTLLFQREGQSGLEICPGREVVTEFAQGDTWSKVHLEAGEIVCNIGDLLMSWSDDRFKSTFHRVKAPCEPGDYFGPRYSMAYFNQPCSDAVIQGPKKKYPPVTGAEFTASAMKRNFAVLAAKRQQLEEEKLKAKSMAPATGTTVAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC28</accession>
    <name>A0A6A6QC28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_622428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC28"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="55986" checksum="69EF2E9E5DD2313D" modified="2020-06-17" version="1">MADHNSEPEIPEIVGADQGGNLGDYADLEELTQELSASDSEVQKALEVVFQASDAHRRKSSLVPTEAQRPANLRRRTQCFVHELLKKQEGLHVGSPNGSYVGLAQEMKMDKDPTPWHEGRHDSRLLTKKQISDMAFGIRELAKKLSHMQLKMNVKNVFILAKAHDETLIHNTREVAEWLLTKDGSYKVYVEDTLEHNAIFNAEELLKSHPAFKGRLKFWTNKLCAEKPQTFDIVLALGGDGTVLYASWLFQRIVPPVLAFSLGSLGFLTKFDYDAFPQTLTQSFLDGITVSLRLRFEATVMRSQRGKNGNSQRDLDLVEELIGEESEDNHTHKPDSTHNILNEVVVDRGPNPTMSTIELFGDDEHYTSVQADGICVSTPTGSTAYNLAAGGSLCHPDNPVILVTAICAHTLSFRPIILPDTIVLRTGVPYDARTSSWASFDGRERVELRPGDYVTISASRFPFPSVLPIGRRNKDWIDSISRTLNWNSRQRQKSYKEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCV3</accession>
    <name>A0A6A6QCV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCV3"/>
    <dbReference type="OrthoDB" id="10425017at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="429" mass="46531" checksum="EB956C2E14114B2C" modified="2020-06-17" version="1">MQDEKTPDAAVIGQMFSSMVKIIKKTSSFERKLQKMVEEARSLSTEASDVCEALMSSDSFPSQVNAQEIRILLDFRQEAGRGEDADRAQTPENPSKRRFTPPTPLSSRDSHSDREYPRSPRVRSSVVSEQSALGSSPTYDGSDGYASGVTATTGDHLEHIEEAPVAQTTQNKEIDLSQIAEYNQGGTAPSAKRSRYDDPHYMYSPCSNCALVNLACDGNPGIVCSACLTDHPNSYCIYEPAHRKPKWKMSEAQLLAITSNPFREPVVIGGRRYQKTDAEWDGIQENQKRKYLKCLEIEGAGGVDASPPCGECVKAGVRCRAPAPETSYGKQNKNNLAKGNAQCARCRLVGKSAACSLILRSPAKCSPSGAGSKEDGLGQPSTVDGGQLGLGDPRSDESMPFPTSTPTPEDVGLLFEEWIPDLGPGFEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDA1</accession>
    <name>A0A6A6QDA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_544339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDA1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="231" mass="26376" checksum="9F692BDE76F23329" modified="2020-06-17" version="1">MEPNPYQILGVPQDANVATIRKAYYHLARVYHPDKIRDPSKQHAQHTARENSQRAYSTPVTQWPPFKRPPHQPERDPSNPLLAPRCFTTRMPGGPDSWAWVTASQARYAHRKSRKARHRAVKTLIRASFARPERAAHPDEDHPIGGWNAIDAHDTVEAYRYTLSLGERGLGELKVALGCTKDAVLWQRYLAEWYDELDAAGFESHDETGQTYKEKEASAMQLAEKLDKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDP0</accession>
    <name>A0A6A6QDP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_494361</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
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    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005506">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
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    <keyword evidence="11 14 16" id="KW-0503">Monooxygenase</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2490392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="532" mass="60375" checksum="5DD1CAC44A419EFE" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEW1</accession>
    <name>A0A6A6QEW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_596950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEW1"/>
    <dbReference type="OrthoDB" id="10657275at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
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        </location>
    </feature>
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        <location>
            <begin position="216"/>
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        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="375" mass="41040" checksum="209D247550ADE3D0" modified="2020-06-17" version="1">MPPTTCEKLPPALVRYTSGRFQKAIESLAYQGNFASRLTFPPPKLIILDVALIQVAEEDEDATSASSIHQTDYRARGRCAESTPSTRPSSTSTSALAESASQDSAAEATPSSSSLRQLSIAEFLAKTDKDLKLPPKDLHLDGPFMPGMNHSTNDDIHAESVRPKASTSLLNPRACSFAPMKAQANSLDRAPAHAVIDLHAVNLKFQPLPSTSADGVQETMRQHDGAERDLADALNKEMDAEETLNDIVTAAIKQSSRAHSAAHLPQQQPHSETLFGTEPQEIDAVKDTSHTLLSEHTKLDENKSSQSDMRSLSVDSPVNKEQAPLPSEGQSMADRLTIGFDGKPEREVYHRSTLCRRWSVDRYYDEDKEYDSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF10</accession>
    <name>A0A6A6QF10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe-II oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_596916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
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        <source>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Gonzalez J."/>
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                <person name="Magnuson J."/>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="352" mass="40154" checksum="6473BC550A9AD270" modified="2020-06-17" version="1">MPTTGPPTPPPEMNCAYKACGAANASYACSACADAPHYNETLAPHPPYDCLPCAHAPKTSRAQPRYPAYDCGARCLEADLKKRQTDCSILASRKTLHRRLALIDIALLAFLEAAYRYKLGRVEEENGELIMYIEQVMDRSDPQPLPQGLEMEVKEAVLTYMACSHAPVLIYELLEELIEQGLVEEIEEIRVIALPTRKMKYVIDNFENSQPQAYVFDPTGRQYGFTQPLLTAAKFLRERCEDNKLHDSWSLGHKAEFHTGLIETFLKENTVEDGGPKYKRLNRRLEFPKRWLGTFEWENKGRTAVNKEWKKWFELQGMSPEKVAELPEQQFEEKKKELGTSILAEVGAIMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QFT0_9PEZI</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
    </evidence>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17082" checksum="A3ABD16B6E28A953" modified="2020-06-17" version="1">MPPKDAKKAGKPTKAGKQANAAAKATLRGVNSHKVRKVRNSTSFHRPKTLELSRAPKYPRRSIPHQPRLDAAKILVHPLNTESAMKKIEENNTLVFIVDVKANKRQIKAALKTQYDVDCVKVNTLIRPDGSKKAFARLTTDVDALDIAATKLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFU0</accession>
    <name>A0A6A6QFU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFU0"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="178" mass="19345" checksum="BF1626C612EC3B54" modified="2020-06-17" version="1">MPTLSRPHLQSISREIHTTRHTSLRPHASSRTKIGRRCPLSPSCPGHAQVETHRPATIGRQSLAAHCRPSPNCNRHSPLAGRSLERRQPNPAPPPEPLQTAAACATLANRQWRILRKRGGKCGEAVVSSLGREEPQLGASVTATSLPKSLSHRAQSRETCHVASAFCGMRRGCLRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG63</accession>
    <name>A0A6A6QG63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentatricopeptide repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_145810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG63"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="614" mass="69336" checksum="5B88C412A9295876" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGD5</accession>
    <name>A0A6A6QGD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_566164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGD5"/>
    <dbReference type="OrthoDB" id="10582710at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025503155" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="55095" checksum="CFE78EFC61DF7727" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGI0</accession>
    <name>A0A6A6QGI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF647-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_469342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGI0"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="53"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="452" mass="48850" checksum="312E5C1090E2CBC6" modified="2020-06-17" version="1">MSPNLSITERDDAGALLATYISSPSSQGSRVDIIVRPHALYPSHVSNQPQHPQHPKSSWRTVLDVFLPAGYPSSVTEDYLEYQIYDSLQAFASSIAGMLSSRAVLEGVGVGDASASPTAALLLNVLQESMGRIATILFAHRLGTALEPECKMYRLAADVFNDAAMVLDCLSPAFPKPVRVLVLGLSSILRSLCGVAAGSAKASLSAHFAQRGNLGELNAKDSSQETVISLLGMLAGSVVVSWVRSAAATWSVLVVLLAVHLGMNHRAVRAVSMRTLNRQRANIVLGELMSSGRVLKPKQVSEKEKVFERDGALRWVDGRVLGYGRIGVDLQTLLHRLGLSHAKTGAVQLDSTLSELAELYRDEAYMLWFDVARSEALIVLKQGSTPIDQLKAWTQALMVARSKQADSLTGLRMGLLEVSKTWKQTAEKLGAAGWDMDVAALETRPGRRVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH41</accession>
    <name>A0A6A6QH41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_126873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH41"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="302" mass="33050" checksum="64EA928FC0E12D51" modified="2020-06-17" version="1">MPHGPVGDFDLNGKIVLITGGGGGIHLELAKLVLAEGAKVIIADLNLQPDGDEFVKANPKTVFFQKTDVAKWTELKHLVKVSEEKFEDVPDVYVAGAGVFEPPWSDYWEDNENERYAYVDINVNHPLKLTRIAVTALLSKNKKGVVAIMASMAGYMGQDVAPMYCTTKHALIGFTRSMGQTDRLEGVKVVTIAPGIVRTPLWLNHPEKQARYGYTDDIAIDAIDVAKGYMKIIKEGKYPGGTVFETCKVGERTIGTWFVSPPGFDPDTPVEGTGVPQEALDQAYQPITDILKKERGTGKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH87</accession>
    <name>A0A6A6QH87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_621295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH87"/>
    <dbReference type="OrthoDB" id="10288438at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="72"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="351" mass="40731" checksum="0DFB9577704D4E35" modified="2020-06-17" version="1">MVRYGSVEVMVYQPQVPDPNQAQTSDSPDESDDRSWVQAPERLVSVLVRGEEANVEVHDGHFGLKLIWHNYRHQSAHIYVTIDGRTFDLWNDMDIANYGVRFWQSPMMKGLQYYKARNKPCIRQFNFAPITKSSLDNTNWEGYDQGGTITIKVFRAKLKALEKPRSLNFTKAEHRSWDDVPSVSAVDVEREYISHLVTLDPEELIQGPPGGGMKMSYKGRHFAPVDIKEPDGKPYRTFKINYRSPAALQEDYITPIEMPHAEIKCWEKDERDKELKYLRTEINRFKQLLDGVYEDQILVEQYGGGPELDEPIEVAEKALDRFEQRYEKLKFERPAGKKSKKRKADAFHSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHD7</accession>
    <name>A0A6A6QHD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease l-psp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_621336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHD7"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="145" mass="15225" checksum="4985CB31D93A2442" modified="2020-06-17" version="1">MEYQGPLTKLGLKCINAPGLGEKLSPLYGISSVIVIPPNATLFETCGHTGCNLDIEYPESLEDEVLQAFQNVENALLAAGVPGGWQGVYKMTTYHVGSIDEAGEGLEAAMAKYLKDNRPAWCGVSVVGLSGPARIEITVSAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHZ1</accession>
    <name>A0A6A6QHZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10508504at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="210" mass="22773" checksum="1748526B233ACDE8" modified="2020-06-17" version="1">MQPTNNNFRYSGHTARGNTYRPNPTGANAMREARARAAEARIWQEAREREAARRNEHRARAYEDLTGQQSQSQGPAVQRQPTAAPRGNARASNAGIVAGGGNRAPTGGATPSWMPNPREREAFTRRYAAPAASRGAGAYAPRTAQASRLPPPAAQSRNHHRSPVHGMADLSDEEAAPPYNPFQNLGSEMVDGGRMDWTRAQPPRGLDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI24</accession>
    <name>A0A6A6QI24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_467961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI24"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="197" mass="21509" checksum="6BFF20E8945AFEC8" modified="2020-06-17" version="1">MSCPELDTVSTDSNGRSVEGTSYVTKWGGYRSGDPPITDGLTEAAHPNFSPSLSPSSSKSARLGNENEGFTKLCKFSAKLFIFRRTDHTWGFHGAGEVVLVKYKSNGVTRLMMRKDKSLKLIMDHRVDPSTKISLNTTSDRSWVFNAKDDVAEGTPRDLTLALRFENSEKAELFKKAFVKAQESNAEVLVPGGGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJG3</accession>
    <name>A0A6A6QJG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_584485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJG3"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="503" mass="58347" checksum="0261FE03F049C0C3" modified="2020-06-17" version="1">MALCEAVARSAGQSLDDITLFTKIAEGGSYRIFQATFKDDVKVIARLPYPSTVPRTYGIASEVATMEYLRLHGVPVPRVFDWSSSTSNQVGSEYIIMERVPGKELEETWYTMTLQERRDMMEKIVDVEKILFAIRFPAIGSLYLKESLRDGIVKVDLPPDATHRETDRFCIGPSTEFLWWYSRRGELAVDRGPWENSEDLLKAVGQRELMWLQKFGEKRFPNEPAYREFYNHQKVDPKVQIASLLDYLKLTPHAIPERDELNQPTIRHPDLSPTNIFISKSGDITGIIDWQHTTILPLFLAAKIPKHFQNYGDDDSENFQPPKLPEDLDSLAEIEKDRQAELYRRRQLHYFYLGFTSRNNTAHFDAMGTYDLVVRNRLYDTASRPWEGDNTSLKAEIIQASTRWPGIATSAMKTAEFPVKYSEAEVAECLDVDAKQKKMDEQMQILRDFFCVNIDGWVPTGLYDEAREKERCIKLQMLEDAETEDERREIRENWPFQDHEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJJ1</accession>
    <name>A0A6A6QJJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_106753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJJ1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="55146" checksum="A89B248FA347AE2A" modified="2020-06-17" version="1">MRESENARFHRYPELEAKRMLVELMEHPSQYNHILESFISRVTCRLAWGHSEANEELKQRARELLIGVSPTGAMGNKLPFLMSLPDWLSPPKAWERRRANTERKFFEIMQKDVERDLREKRAPQSWMKTFLEHRGSWGFQYDMEGAYSVGMHGIAGALTIAAPMQTFCLAMTHYPQYLPMLQEELDRVCGDRPPRSEDRENLPFLRAVIRECLRWRPPVPTGIPHYLIQDDSYAGYHIPKGSVMHPLEWAISRDPAMFPDPESFNPLRWVKPEFPTYREPLTQYPTVINCTQFGYGRRVCQGQGVADEDMLIGIGSIAWLFNIAKKGENDSDESCGDSGYDSLSETEELDEKDGLRRHHANATISAEELNAGLEKPETAEELFYPGAWPAADIAEEEVHLEKIRVKTKKSSQDLDPTLDFTTLLIAKPVPFAFELSIRTRDRAEKARSLFEEEQAKGAYSSSRAYWGEDQGKGKELGWGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL41</accession>
    <name>A0A6A6QL41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_620788</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL41"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2492413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="418" mass="45998" checksum="2D5F71F966F4F828" modified="2020-06-17" version="1">MPDDSILIMPHSVHTSLAMSDHRASLSSSSPFVFPRAAGAEVLAGDYTMDERSPTQSNFSALGSVKSNPPNSSEFEPLVDHSKITRHIVYGAPGEKKDSDTSKHRPQTHKSRRRTQYYEEQFSERYKDSPGSVRERTSRDSPIIAELRTNVIMKDEYPLIMDLSQTLAHRYQRPDSSVMVTLEHSACLLLGGTFDPTYILTITALPVHIQPSTNKRNAALLQSFLLETLGVPSHRGIIKFQSIPEENLAMNGTTILGEIERLEKQLAEENGSALKRTMTKASRKSLVLKPKPSLPTMGSSPTVVNGHSPSYPPMLTPVPVEIDDADGPSSLLSDSKHLSELSSPLNRKLSKVLIKGNIPSSQAEGTSSKRDRARKRHTEARPAGKATALPKVPLPLRIPAEPTPKIGKRKSLIAIFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLR9</accession>
    <name>A0A6A6QLR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_528625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLR9"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="14"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="538" mass="60639" checksum="0A1EE00A76DF2AAD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMQ4</accession>
    <name>A0A6A6QMQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_563813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMQ4"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="496" mass="55930" checksum="5B4F114339C1A71D" modified="2020-06-17" version="1">MISFSLSLTSFIALILLRCIYLKYFHALSRYPGPFIASFTNLWRTIRFAKVDLHLDTDDLHAKYGSIVRFGPNSLSFSSVEAYDAIYGFSARGFKKGSSYDFARNKATGRTTVFAAADDATHREHRRKTIIAFGNRVPAYAPVIKKHVEALIERMKRFTREDGVVDIPGLLHRFLLNALFDTSFARELPVALPTPGEVDTLSQGFHMVSASIFTSSWLPWLNWVLNTGTVQKMIQKPKYESNGTLVPLSRFFQSAEQIIAQNQPALETNTKSQPSILQNYLAVPENDSRRMTEPQINIEAINLIFAGQGSATAALTSILWQLGLPAGRPWPQKIRAADTREAAFEAVVRETLRFLPPFPTGFPRDITRETQTAIPGILAPLPVGTEVSVNYWLLCRSKELFGQDADLWDPNRWLLNALDRESELQVDHVLDEKFLVFGRGPRACLGQDFARLVIREVVIAVLERWEIEAVGELKGKNVFESRSDKAEVRLRELQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNI8</accession>
    <name>A0A6A6QNI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNI8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025438891" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="77" mass="8152" checksum="438CFF6474A959BC" modified="2020-06-17" version="1">MKVTTMIVGALATLSALATAAPVTNEKRTDDEASCSACQEDFLACSVPCAHFTCAKICKQAVCSNSMCRNRCGFHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNM5</accession>
    <name>A0A6A6QNM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_511944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNM5"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2493842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="692" mass="77378" checksum="03E1E274DEDCE09D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNU0</accession>
    <name>A0A6A6QNU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_582840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNU0"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="3">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2493789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="483" mass="53334" checksum="130ADC2310CFB1FE" modified="2020-06-17" version="1">MEVAGLALGVAGLARLFSACANGFALIRRGRALGHDVRILEAKFSNQELRLRAWGRACGFAEDGEAGRRGVEGAETNKNYDERLDVPELRANVAETLECITTLLYDGAGLRGRYGLKPFPVDENNDASSPTADSADGVEKRKNFNRLSFLHSSRANKEKSSSFRSSAAWAIEDRSKFAELVSLLKDLVDDLEDITRATDIPRRQLVFIGYEIEAITDVETLEEMEMTGEGEHDTVSDAASLRLEVISGAASSVRASIGSRSLRSFRTLQSYETARSRFSDPSSRSSVASTADRNTRVDLKCAKVLVTGPLESYKTHLLQNFISTSILRHYKRAVFERYQAASPAFLLNGHIVVPFRYDDHEIMFSLWDTVGEENYDRRQLYSNADVVLICNSASVTGRNEMRQTWAPEAKSSNTPYMLVNIKPGDGDNGVFTNVAEETEEGAHVSTSEILGLNLGDEFGALSYLQCSLSDENSVTQVFERVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNZ7</accession>
    <name>A0A6A6QNZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1763-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_528255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNZ7"/>
    <dbReference type="OrthoDB" id="4392610at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="132" mass="15733" checksum="E544AF31CC48F3B7" modified="2020-06-17" version="1">MSSKIVHAYRHLYRHGLRAVQFSTPARYTLRDRLRLAFRTGDPLEFSQSKIDNTIEFLKGATRETGLEHRLLKSFLHVWFHQGRPRMPRNKNDADQNWTRYTAYDPWNHNIRMLNESMGMCLPMSQPPLLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP78</accession>
    <name>A0A6A6QP78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_463634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP78"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025376885" description="Cellulase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="12">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2494012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="343" mass="34388" checksum="06C89103867A0462" modified="2020-06-17" version="1">MKTLALLALLGGSATITNAQTSGTGATTRYWDCCKGSCGWAGKASVSSPVVSCDISDNPLADMAAKSNCDSSVSNGPAFMCSNQSPWAVNDDLSYGFAAVNIAGGSESSWCCSCYELTFTSGPVSGKKFVVQATNTGGDLGSNQFDLAIPGGGVGIYNGCTNEWGAPANGWGAQYGGISSRSDCDSFPDKLKPGCYWRFDWFQNANNPAVSWKKVTCPTQLTELTGCARNDETPTPGVSGTLSATATAKGASSSVAAAIKLSSAAAKSSSAAVKSSSAAAKSSSAAVKSSSAAAKSSSAAAATASSGGNGLTAAHWAQCGGKSWTGATEVCFEDALIVEDAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPG8</accession>
    <name>A0A6A6QPG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_490326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPG8"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2493603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="363" mass="39668" checksum="3253579AD027AFE0" modified="2020-06-17" version="1">MATKLPQIRGIASLSIRRRLYGTAQTAPSPQIFRDVPPLRTYRRSLLLSKRTVGLVPTMGALHDGHLSLARLAAAENTDVFISVYINPTQFGLNEDLSSYPKTWEADLAALKNLDAELAATPGAGRISAVFAPTTKTMYPTLPPDSSLPGKGSFVTITPLANLLEGASRPVFFRGVATVCMKLFNICTPERVYFGQKDVQQTAVIRRLAKDFHVDTTVRIGPTQREESGLAMSSRNVYLGTRRREVARVLSQALRRAEAQYLAGKRTRGDILWPATAHADEVAAAQEELEPGARAKFEVDYISLADPETMEEVEVVDPARGAILSTAMKMLPLEEVAEGEQLGVGKDEIAVRLIDNIILEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPP8</accession>
    <name>A0A6A6QPP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_540820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPP8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="142"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2494341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="558" mass="63095" checksum="C90310E4CB678844" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ77</accession>
    <name>A0A6A6QQ77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_540802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="199" mass="22260" checksum="46C99C7578FB1573" modified="2020-06-17" version="1">MLAIQIPSTKSPECTPNLLPARLNHDGPVNATERHWNPETTENGDTTAFFRGRKLKGRTVKIPEGYKGVVLDITDKAAPQPKKVQNEGRADDEGDNEEEEDPVDVKAVEELATFEEIVVWGHEAAPANTEDPYAKGVHEWIGFAEAVAVWKQACTITCWSLGEHYKPRHAPTPKYQAPVRTVSNGQHYPVEAKQYRKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ80</accession>
    <name>A0A6A6QQ80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_463976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="319" mass="37276" checksum="F3B4389FA31C70E5" modified="2020-06-17" version="1">MPHSRRKCSHIHPKRYQSSRLNCKRGRTLATTITQYRYENGRRYHAFRDGEYYQPNDEKQYDYEMIVHHLWLLSLDDKLFSAPLNNPQKILDVGTGTGVWAVDIADIFPDAEIIGTDLSPTQTAMAPPNIRFEIDDCNSEWVYPEDSFDFVHMRSLSGCVSDWPALYRQCFKHIQPGGYLQHCEFSVRVINNEPGPQTARAEEMYKMYTDLVLQTGDMIGKSFSVDQNMPELIKEAGFVDIVDSKPIWPIGPWSSDERLKEVGKWNQRSWLDGLESWVLALFTRQLGWSAAQVRTWVEEMRHVIRDRNCHFYNEVYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQI8</accession>
    <name>A0A6A6QQI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_426010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQI8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="35235" checksum="E5CB3D3C99F787CC" modified="2020-06-17" version="1" fragment="single">MRLLHTSTFEVKSFFDQNLPPYAILSHTWGNEEVTLRELQQETTASIESTKKGFVKLVGCALQAERNGFSYIWCDTCCIDKTNSTELSEAINSMFYWYKNQLCYAYLDDVPHSPGGVSLEEDSAFARSRWFTRGWTLQELIAPRSVIFFDARWHPMGSRSQFSDFISDKTGIDRSVLNGQDPALSSIAKRMSWASRRQTTRIEDMAYSLIGLFGVNMPLLYGEREKAFLRLQEEIMKAIEDHSLFAWKTPALGFLETGSLLYSGLLATSPADFAESRNILPFQQEMGDGMDVSQPPYSMTNKGISISLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQI9</accession>
    <name>A0A6A6QQI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_618523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQI9"/>
    <dbReference type="OrthoDB" id="3644873at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="465" mass="53887" checksum="A83DD277BCAA4E8F" modified="2020-06-17" version="1">MSNDVQPRDLNSSFGQHRFQDNGERWRPHHFTQYLCPDHALLEKCRSIYDHSQDEPFILRLFRPDNQENRMEPDPAPPPWRSEDCMYFSITEAAADPVSSDIIGQERTAQYIYENEQASGGQVCHAAERLEHDMDRVSKYAGRTTLGLVTGYFQFFVSRNTEIDIPNGGLFPIRESEDYSMTLLKWMELGARLKRQAERQQQPLKVWWDRMETLRLAKTDRAYHSVQLAMGRIGRLDSYNGLKKWKTPPIDSRLTDAWRDELGDSEEDTRCLICLEQFTYKGPKRAARLECNHVFCRNCIKRWVESTSPPKPCPACRKAIRPPTPRTITPPPVFGPYDQPVTIKCAVLEDWYHEFKVKEEASTYSERRLNPIFCSEVTVMEQVFNSILPPAEGVTCSPSHFSITLQQAVSGRLRELLSLFSTFPALRDRLFPGFEKLCGRICDGMAVRLQEQEQEMKWDDEDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQQ1</accession>
    <name>A0A6A6QQQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_540819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQQ1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="402" mass="45434" checksum="9023B0781C93C613" modified="2020-06-17" version="1">MAIRDYRALIPCTVFFAISTALIFMRMYVRGARLRNIGTDDVLCCIAGLFNIGVTTCFLLRIEYDYRTVDWIQTPHEMRVSMLSYYLSMPLYQLALGCIKASIIFQYRRIFRDALGPACTVLLAIIICNSTAFFLIMILRCSPIDGPWTNHSTACMDVKLINYVFIAINFSTDIVLLLLPMRILRDLNLAQAEKRGLVFVFGLGGFAALTSILRLQYVLALRSDGNKVYNGLLMWCCIEISVSIICASLPSLNGIMARRFPHVWRKDSDDSSSRRSSRWTPRELRKKLYATNSKGQESTERISGAITVAERNPSRSSKQKIQVTTTLQQSVEDKPAGTNAEPRAVTFCEPSVKGREERYDWCNQKSWVADMVAEITEPRNEHGRANDGPSETGLEMIPLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQU5</accession>
    <name>A0A6A6QQU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_527591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQU5"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="178"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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                <person name="Bloem J."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRH1"/>
    <dbReference type="OrthoDB" id="3944420at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025503655" evidence="3">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="211"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="396" mass="40535" checksum="A16EECB766FFD282" modified="2020-06-17" version="1">MKNLVFLLALTASLRTAFGQSAGTVSSIISKTTSSSSVKPSSTLPSLPDAAANHGAGQWGDKFNQGAGGGENSGGAQTAWIPTDGSTPPDEAVAKFLMARQAGLSSQYLYQLSPNLVDSAALRGFTGSLVPTLDTQDANLGGSAQVFLSHGERDTLSTTTRRSLHERSLCTNATAPIHLFSGLGNSVTILQADIPFDGGILHVTDGFFTLPKSLPDSLSLTPEAATFGSYLNSSNTSFDATPAATVFAPNNAAVLAALSTNQTLTADQATALVGAHVVTGYVAYSPLLISGTTLKTVSGPSITIGTGSDGSILVNGKSKIVKADIVITNGVVHLIDKVLFTPPSLTTPSATPPPQFTGAASWSPHDIRGTGWFGGIVWPVFVAAMIALGGNMVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSG8</accession>
    <name>A0A6A6QSG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_511593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSG8"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="6">
        <location>
            <begin position="43"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="209" mass="23422" checksum="EE2CA3E89D73E8AC" modified="2020-06-17" version="1">MPPRKRKTAAGDASEEPPAKKSQKGTKATPSTHAALTSPSTRNYWLMKAEPTTRLENGHDVKFSIDDLAARTRPEPWDGIRNHVAKNNLLAMKRGDLAFFYHSNCKVPGIVGVMEIVQEASPDETAWDSKSAYYDAKSGPDKRTWYLVHVEFRRKFKDIVGLKELQGYKGNGQALEGMQLLKQSRLSVSKVAEKEWEFIMGLAEGKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSL3</accession>
    <name>A0A6A6QSL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_540431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSL3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="222" mass="25053" checksum="7FF26121C30E7841" modified="2020-06-17" version="1">MENLTQPQQPPPTPLSPSNAPQTSHPATPKKHQTPSSPASPSPRAPSPAAPPPPHGPNPLPLPQPSQQPKHQHQPRPDHLVRAPNRSPAAARPRAPWRHAAEQCGGESGARTAARNGRDLLFYHTMGWREWMARESVEEAEVWWRKEAWEVEGVMEGWRRRIEEGVTHPVLATYPVEQEMWEKTAAIVRKLGERHLEQGGVVDGEWVEKVRRVERMLVLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT11</accession>
    <name>A0A6A6QT11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_461018</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Proline-directed serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="EMBL" id="MU004189">
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    </dbReference>
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    </dbReference>
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            <begin position="24"/>
            <end position="312"/>
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        <location>
            <position position="54"/>
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        <ligand>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2495262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="356" mass="41237" checksum="233C86FB96D4CC72" modified="2020-06-17" version="1">MSRAPTASATGSSRKISFNVSEQYDIQDVVGEGAYGVVCSALHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRNYETFTEVYLIQELMETDMHRVIRTQELSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASTEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKIPWKAMFPKTSELALDLLERLLAFNPVKRITVEDALKHPYLEPYHDPDDEPTADPIPEEFFDFDKNKDNLTKEQLKLLIYQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT37</accession>
    <name>A0A6A6QT37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_550109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="34326" checksum="EF060DA3CE47A801" modified="2020-06-17" version="1">MPTVLEPAAKLPLAVRKNVRDKFESKKEGLEKQLSDILGETWKIDINPNAIYVYAEDNSYGKDNLGGCLHSYVADTIWNLKYFLEKHGDLGKTELNTVATAHTLTLAFDESGTVRYASCDIHDGTLRLLFQENNLGTNISAATKIEQLESALCAATPDAPLSYSARINIAKAWDAKLPELQKKIGAQLANDKIVLDPNFVAVYAALKAAPVVAKERPDWEQSLGYIMNQYFNGLLHTLAYQKFEKDDMLQEGFAEAVEKGEIRFRVVEKLGRTYNESVIEEGVFWMQTKPETWATNCGDVGSDVVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTD7</accession>
    <name>A0A6A6QTD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_486875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="82678" checksum="E65349A336111064" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTR4</accession>
    <name>A0A6A6QTR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_487028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTR4"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="36170" checksum="3C706A752485E54D" modified="2020-06-17" version="1">MTQSNDTIQYVYAKNGTAIPEYLCTVSICSLDYAQVEYLPSLAGNLIYLIIFAVLFIAQCFFGIRHKTWGFFVGMFCGIVLEVLGYAGRVMLHGDPFDFNSFLLYLIPLTIGPAFLSAAIYLCLGRIIMAYGPDSSRFQPKTYMFIFCGCDFFSLLLQSVGGAIAATANDKAGSDMGANIMVAGLAFQVFSLLVFIGLAGDYALRVHRAPKSNYQKFSELRASKYFKYFKWSLAVATFAILIRSIFRVIELQSGFGGSVANNEALFMIFEGPFVIIACFFLTICHPGLVFKGLWAESNWSLRGRKSAGKESLDSEEGVVLSSYQQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU98</accession>
    <name>A0A6A6QU98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_362660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU98"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2495981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="29184" checksum="A5A2F06C9B80D7D3" modified="2020-06-17" version="1">MQSASRLHKALKKGGATFGAWQMLPGANISKTLAITGVDWICVDTEHGNIDDAQMHEAVTAVASFGISPVVRIAANEAWMVKRALDSGAHGIIVPLLYTPEDARRLVSSAKFPPLGTRGFGSPFAPNTFIASTSPDGPHKPVALMDYLQQANGSLVTIVQIETAEALANVDAIAAIDGIDVLLIGPFDLGNNIGRPILAPELHPELKEAIAKIHAAAGRHGKGTGIYCTGLEQAKMYQEHGFHMISICNDVGALSGFFGNALQILKPSSGAAGGEVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUB3</accession>
    <name>A0A6A6QUB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1604-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_572129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUB3"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="711" mass="76481" checksum="17FD23D004A13E3C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVR9</accession>
    <name>A0A6A6QVR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_618923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2495007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVR9"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33890" checksum="236B46BA6443B041" modified="2020-06-17" version="1">MPVSSVARHHDLDDRGEGVNNHSSSARPSQLGNRERPFPFLGLPKELRLKVYENIPEVTKRPLPLNLKNEPTDEIYWRQWTIDTAILDTNKTISHEASAVLWQIVTRLQAETMILEVIVHSAKDPSPQFLNSPGTPSIFVDIVPVVYSALIMNLPLRPLTLIGRAGCFLQSYAKWCELARLTPVEYEADRSEANWLLHRTLMCENLEIHLLYDSNACSVLSICFKILQVLAVAHLARSLPTDGATGYAVKMGYGIKVAERGGGELLLPEEFAEKHKDSLPLEYFNMLTGISQPPSVFRFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW87</accession>
    <name>A0A6A6QW87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_561516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW87"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="28754" checksum="AF0BE4FF2B233E7D" modified="2020-06-17" version="1">MNYEDTHSNIRASCYVVDAATTALQGYHYSTTGAGGGMPSPPQSPPLAAYNSHATKRPASDNGSRSGRARRGGAAYTITEECERLFCGTLRAVFLGEGNSADQDSLVAGVQNYNITTSAFGSDINAHARYAHSTRGLPSPEMDGFVESGGLVTDWMEMFDYVGGTRFRGFVAEKDGERAMFVFFDNQVVGNDLKPGLMALLELCDIPSFECSQLVVCLDRHTESHAMSTLSRDLGWVGFSLTTLDEWTNGDEITSDSWIFMGMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW93</accession>
    <name>A0A6A6QW93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_375934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW93"/>
    <dbReference type="OrthoDB" id="10522130at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="71" mass="7629" checksum="1AE7EFD8D60CDEBF" modified="2020-06-17" version="1">MTRCYSDGSVDPVVCAWGTRSKHVSAENAEQYQQQTVAGLHTSGLGTDGFTTAVNYMGTLMAFPGLVLMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWW5</accession>
    <name>A0A6A6QWW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_560244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWW5"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="149"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="630" mass="68508" checksum="E4AFA44B1FDB807E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXP6</accession>
    <name>A0A6A6QXP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_526249</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXP6"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2497228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="39776" checksum="4F91BF8B67B2CCCB" modified="2020-06-17" version="1">MSKLDWIQYGTPSLDRPFGLELWPIFEKGFGAVVGYKPQDFRFESGETTLSTFKATAIMLASYYVIIFGGRELMRGREPFQLSFFFKVHNFYLTLISGTLLALFAEQLIPIVARNGVFFAICDHNGGWTDKLVILYYLNYLTKFVELIDTCFLFLKKKPLTFLHTYHHGATALLCYTQLIGNTSVSWVPITLNLMVHVVMYWYYFQSARGIRIWWKKYITVMQIVQFVLDLGFVYFASWTYFTSTYWNWLPNAGKCAGEEFAAIAGICILTSYLVLFISFYFATYSKPIPKGRRRATSALVEMKDEKVPTVAEARRRLSQGAHSLANGHATSTGSATPNGRVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY66</accession>
    <name>A0A6A6QY66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_616046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY66"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="300" mass="32323" checksum="80061C6B2838400D" modified="2020-06-17" version="1">MAPSAVSLPPAPSTKAAQEEAERTSGDPALAFIQDEGTSPPVFEDKYEERKYLKHRLAIAFRIFASSGFADGVAGHITMRDPLDPTSFWVNPFGMHFSLIRDEDLILVNHAGEVIDGGKNLRLNYAAYAIHAEIHKARPDVTFAAHSHSTYGRAFCATGRTLDPLTQDACVFYNDHVLYANFAGVVLAAEEGKSIAKELGSKKAALLGNHGLLTVGPSIEAVVAWFVLLEKCCEVQLLADASSAGSGKPLVKIGESEAQNTWEALGKPATGYFMGLPLFQIAEKKEFGESTFLGRGLEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY96</accession>
    <name>A0A6A6QY96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BU16DRAFT_341092</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY96"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2497421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="134852" checksum="7C57FF900E16AAD4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ64</accession>
    <name>A0A6A6QZ64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_559486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ64"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2497751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="109" mass="12104" checksum="3F4E022AE2726F7D" modified="2020-06-17" version="1">MPGFEAGDAKKGANLFKTRCAQCHTLKEGEGNKIGPNLHGLFGRKTGQVEGFSYTDANKQKGITWDNDTLFSYLENPKKYIPGTKMAFGGLKKPKDRNDLITYLSEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZP2</accession>
    <name>A0A6A6QZP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_329097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZP2"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025565578" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="182" mass="19970" checksum="8200051D4AEF9FC0" modified="2020-06-17" version="1">MAVSILCRILTALAALQIAVALNIPSSVEKSYIQPSRRLSLIATSKEAYLNLELRPRNEFYYQNETTASFIVDTSVNYEHRGSPFTNKTFTPGRIDSVPFTTMKIQITNTLDSMTLVAWSDVAVNSMSNEFAFNLSSLAPKASAYPVNIIGISPDGIQSYYATSSITVLLAGELRNNRTVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Y5</accession>
    <name>A0A6A6R0Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_294255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Y5"/>
    <dbReference type="OrthoDB" id="5400539at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="24688" checksum="485FFFA81A07C39A" modified="2020-06-17" version="1">MPAMFSKRSDCVEDFNGDIQCYQYDGFWYTTKGEIIKWCILAAIFVFFMAWFLGGYIHAKSRLRKGLPLLAYHRWLVPLRDRQRYGQTPYGQAPQNHFTFYNTQQQQYQQQPYRANDGTYFEPPPVYNHDAPPSYVPPPGATKLHPQQNAMEMRPHVGSGSQEPGGYGMAPGYSGPAGQETGVVGGGQPSDIENQSAELPPRPQRAKLAVGNLLGKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1A0</accession>
    <name>A0A6A6R1A0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_504498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1A0"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025369951" description="ribonuclease T2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="35065" checksum="A9275ED0E0C96344" modified="2020-06-17" version="1">MRSQFVFSGALLLAPAIASLYGESNLNHTCLFSKPLLSCSPGAIPSEVDTCCVETFGGLLLQTQIWSSYTGFESEGQVLPKNSWTVHGLWPDFCNGSYTQYCDLNRQYDPNPSPNTTNALPNGTVVPPYKGPGISTFVEAFGKFDLLAWMNKYWVSSGSPNQDFWGHEFSKHATCYSTFDVPCYGPQYKEHEEVVDFFETTIKFFQKYPTFQWLAQDGIRPTNVTAYSLSDIQGTLAKRSGGIPYVSCTGPRYNTTDAGKGSLDNGATVLGEIWYYSHVKGRPQDSHSVPTDATGSTSNCAKAPNAVHYYQRAKGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1B5</accession>
    <name>A0A6A6R1B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_524427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1B5"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000007">
        <property type="entry name" value="Cytoplasmic protein required for cell viability"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="71"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="197" mass="21348" checksum="13CC4DC8638954A4" modified="2020-06-17" version="1">MDPDKDNANPTILNPSDLPSRRANASLKKRDDGGTGLFDHLIPAYTYLNDPFDAPASASDSDDDVVEDIDEQEIYDLISTISDPEHPLSLGSLAVVNLPDIRILPPTTLKSPISTVVVEITPTITHCSLATVIGLGVRVRLEQALPPRFRVDVRIKKGTHSTDEAVNKQLGDKERVAAALENGTLMGVLRKMLATCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1E8</accession>
    <name>A0A6A6R1E8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_524625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1E8"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="21"/>
            <end position="50"/>
        </location>
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            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
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            <end position="94"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2498521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="653" mass="73655" checksum="EE81C09B2E6864E5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1V9</accession>
    <name>A0A6A6R1V9_9PEZI</name>
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        <submittedName>
            <fullName evidence="20">KEX1 protease</fullName>
        </submittedName>
    </protein>
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        <name evidence="20" type="ORF">BU16DRAFT_524812</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025581837" evidence="18">
        <location>
            <begin position="21"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="713"/>
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        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="471"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="634"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2498748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="847" mass="92883" checksum="414F1126C28DF5DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2K1</accession>
    <name>A0A6A6R2K1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="180" mass="21208" checksum="178BD9532FB34DC1" modified="2020-06-17" version="1">MGKGYYSSQYSFRMEEDGYSPMGAGGSRDWKQIEARLKEVERLIKESNLQRKVRKITINVDQAEEKVQKQLAKEEKERIAEFKRSTKNNRQRERKDAEALKKRREQEDQEARDAEKQLKDERKAMQQKLRTQQVVFTIPEEPTGVQNREVEEGVVKSASGRPQRTRNTPKRFHNSVIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3B1</accession>
    <name>A0A6A6R3B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_559613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3B1"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="40656" checksum="66D495EA3E3AF7BC" modified="2020-06-17" version="1">MIPLRTSSQKSPVAVAVTFAAIATISVTLRLFARRKKRLQLEWDDYSIFLALVCFLGLVGCDIVGVVHGGVGLHVTEVVGKYGRQPLTIFAKDLIAVQILWATSLMFTKTSILFFYTRIFTVPAFRLAARIIGVVVVLWALSVIICGFLLCRPFAFNWDQTIPNGHCGNQILSYELTGAFNICTDVIVLALPLPLIWNLQMKRANKIGLLGVFTVGFFVCVVSVVRLITLIHLSYSDITYSVPNALIWSMLEPAIGITLACLPVIRPLLGSGFSSLSKSKNTSEKLHSSNFQQLDEDYPLRSLGDSKRTMNVEAGSEHGSTREINVPEINEQYAIENTGPLDAHRMSKRDQKITVTQEFTQEWTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3I2</accession>
    <name>A0A6A6R3I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3I2"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="78" mass="8892" checksum="469A9370F607D5C0" modified="2020-06-17" version="1">MVFRRADPSAINLTSKLFEYTPTQRPSAIDAIYQPFLDEFEGPDHEPLNIKHPTRPFLGLPKLSNDTLLEMLIAPQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R445</accession>
    <name>A0A6A6R445_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_558260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R445"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03485">
        <property type="entry name" value="MutL_Trans_hPMS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="230"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="893" mass="98869" checksum="A4D69FABB69FA375" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4J8</accession>
    <name>A0A6A6R4J8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_278929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2499651.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="169"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="946"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1157"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2499651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137199" checksum="38417AE4D1E20840" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R556</accession>
    <name>A0A6A6R556_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_455739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
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    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="36680" checksum="910763B9917CD905" modified="2020-06-17" version="1">MTNLDLLLLKGPPTGDLAGGLNDLRFTILTKGMPANGDGMSDLRIYIWLILLNAPPVRTDVYLDLVRQGASPAYTKIRNDTFRTLATDPLFRRRVTENSLTRVLNAVAWKLNDAHEARVNGWQSPPTLSDFGGSHDNTFNSRQSFTTGTRTEVSNSDAEQVGYVQGMNVLAAPFLYAARSEVEAFVAFERLITQECPAYVRGPMDGVHKGLRLVDTVLEIVDPKLYSHLMSKGMHAELYAFASVLTMSACTPPLPEVLQLWDFLFAYGPHLNILCIVAQLILIRDQILGSPSPNQILRSFPPLQAAKVIQVATSFAAKIPADIYEQIINHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R562</accession>
    <name>A0A6A6R562_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_536026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R562"/>
    <dbReference type="OrthoDB" id="3796575at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025526901" evidence="1">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="176" mass="17962" checksum="489D76712F9AACB6" modified="2020-06-17" version="1">MLLSALFLCLTVPIVAASRVRQAKHHGLVQRQGLTINDVCGLSPVDCGGGWCCYSGQNCIKTGGDPLCEDLLLTDVGGGPMTVYAIQWSSLVNGLSALTSLGVTLSTFPTTLTAATALPSYSNSDTSVVIPTWTGYPATTSTTSTSKGPAATVMPDKKILGWVPAAVALGVAAGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5N3</accession>
    <name>A0A6A6R5N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_547930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5N3"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="46"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="669"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="760" mass="85837" checksum="3A909414906DEFE6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R606</accession>
    <name>A0A6A6R606_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_452392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2499999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R606"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="242"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="54329" checksum="C5D617F18AC66FA7" modified="2020-06-17" version="1">MLPSFIQAIFPSLGGPKRIRDVVRACDRSLEDYRSEVQRLFEAPLNAKSLLAMSAKLQAQFYPKLQASNICMLPSYNHTLPTGDEQGTYLALDVGGSTFRVALVELNGQSAGAESMRITHMRSFRIDNAIRSLKGHAFFDWMALKIEESISGPEGKSWNNGSTLPMGLAWSFPVEQTSIRSGMLLSMGKGFLATEGTLGQDLGELIMKSCQERNLNVRMDSIVNDASATLLSRAYKDNSTRLALILGTGFNAAVHLPVSALAHSKFGQRPQSWHDQADHVLVNTELSMFGKDILPTTRWDDTLNANHTHPDFQPFEHLVSGRYLGEIVRLVLLEAVRTAGLFGGEVPDKLSEAYSLDTGIIAIFESDDSASLSQACTAFQTAHPLSKPPTFSDLSFVRHISQLVSHRAAAYLAAGIHALWSLRASAEGLSPSCVGRVSIGCNGSVIEKYPYFKDLCQSYLDELTDLSGAEPHSVVLEPAVESAIFGAAVGVCCLEEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7D4</accession>
    <name>A0A6A6R7D4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7D4"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025624661" description="HRQ family protein 2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41199" checksum="BDB6408088310089" modified="2020-06-17" version="1">MSNPTFGMPVWIVLIVLVAWLGVKALTRLHRHASKSHQAPTDDVYNKIEPLSDFKWQTTEPLQIRPFKPRYHLTMALQNTTMSELVAKDKTYVDRINLRRQLINDHPNDVVAANPRIVPAVKEFHAWMFGTYLPSRYSSMFKLIPASGPGQDAQCVNRVTSDTIPVYTEDAISSLRVLGEHIDTDFLFLLPSESPADEGKYRLEGFITCFPSGFNTPQKLNLTLADIHAPVPGYGVKIEKSMDRFFATLPTGKIVLRTNWSITTNTRLFSLGGNHLYEGEEAVEEVVDIDKTMLRCERQTLHRLPESKALVFAFRTYQYPIRAVKEEGNGEALADAIDGLSSGSVPGMAVYKRGVVWGSAVKAFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7I2</accession>
    <name>A0A6A6R7I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_244039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7I2"/>
    <dbReference type="OrthoDB" id="3913010at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="15422" checksum="4B7A0CADCB238C1B" modified="2020-06-17" version="1">MTTESNVRSHAGCCMGHCRAQRFAMDSHCAVAFEKEKASIKAYEDGWDEWDGPIWPWRETNNPEAQQKLENEYQGCCSTPEQHTIDTTLANAHQPQTHTDSLRPTRPASVAGSVSPSSSLWSSRTTSPCPTCGRGATSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7S6</accession>
    <name>A0A6A6R7S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_578683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7S6"/>
    <dbReference type="OrthoDB" id="5384459at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="119"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="404" mass="44319" checksum="B4B74496E6E6F707" modified="2020-06-17" version="1">MAPANTRPISMEGIECVPLEREIGFSGKQVVHTTEKELVSNLECEKSGDLPLPWLGLQWARIHVRWLRTSLKYRVLIAIAIGAFIALVLGIYLGLSLKKSKSSSPPTVTSDLIPQQSVLFYASAIPTATSLPTLPVGSFNLETTNPQRDTHGCLSAASEATAWSCDLAFQGYDLAVRQTSSTFLGVSLEAIYDQSSYGVQVPVFYGLKEGLLNLALVTDLDNAALGPAYHFQTTYDKVVLLPDSDFPAPTSRKRSTQHLSRRGQLQPGDQLWACYWNGTLIEGFFYVESNSTQIASPTSTLSSSPSSALPSTSSSRFPNAPFATKIEERRLSVNSVPGYCQKMQLLLTGNFVPLTDTSGNAIVVRLDENDPNPGEFHSGSAKRKKARKHKREDPENSCHCQWMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7X9</accession>
    <name>A0A6A6R7X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_284918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7X9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="17023" checksum="77CAAEE75FF08426" modified="2020-06-17" version="1">MHRIIIVRHGSVSAASACEASHRSSLVLCFFVCLSGHMTPLVVKDHGAHVLAVRFFCWGGIKPRPPSSFVSFCREGLGAGSIKKHTQQLIMVWSSLRGVGSKAAGSARVCGCWLLEGGVKTHVSYSQWCGGWGSGVQNWQHPNIMGWVERACSQHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8J8</accession>
    <name>A0A6A6R8J8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclohexanone 1,2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_577364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8J8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="580" mass="65516" checksum="88FCA720700C3728" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9S1</accession>
    <name>A0A6A6R9S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_599434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9S1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025511193" description="chitinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="40"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2501488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="431" mass="46647" checksum="9DF2A50CA0ABB9AC" modified="2020-06-17" version="1">MRFASTLSIGLSWLALAAALPTTSVHSFRSEIEDRAASGLRSVAYFVNWAIYARNFQPQQLDASKLTHVLYAFANVHPDTGEVYLSDTYADTDKHYPADSWNDVGTNVYGCVKQLFLLKKQNRKLKVLLSIGGWTYSSNFPQAASTDANRANFASTAVGFIKDLGFDGIDIDWEYPSDTTQAANMVLLLAAVRSALDQYSSANAGGQHLLLTVASPAGPAHYQAMNLKDMDQYLDFWNLMAYDYAGSWDTTSGHDANIYPSTSNPTSTPFNTDQAIAYYTGVGIAANKIVMGMPLYGRAFDQTDGIGKPYTGNGAGTWEAGVYDYKALPQAGATVMTDTQAVASYSYDSSKRFLVSYDTPAIAVTKANYIKSKGLGGGMWWESSSDKNGTDSLITTVVNQFGGISALDSSNNLLSYPQSKYDNLKSGFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA44</accession>
    <name>A0A6A6RA44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_555787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA44"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="466" mass="51816" checksum="F33C774A7CEE18A3" modified="2020-06-17" version="1">MAKTTHDPSPSYESVPNIARTRGTTQGSRPRMRGIQWWTKLVPFYVIIPVAVSLAIEILHIRLYKNTESLYRWSTYDRTSVQVIVHILSTILAILLVYPVCTVLSFWTRHRLSRRDVGLNRLRLWSAMVQGRLDWSLPWLPSLLALGFFALTYLPAAVWAGALTPVLTVKVEHNLPFHIPAGGPGGDYALSPIQLSSGIFGECWTALQSNGTFTNCPQKYDTGNLLQTIASATSSNMAPRNHSKWDNTDYQYIGLSYGVGAATGLTDDGLLNLTSNVQGYNYTEIGLITKTSCIYNESATWRVYEADDMASTPPYQWYYASGQLPNSDWSIINISNPTAAGTDFFYQLDFKDGNEVVATLARPPISRDFSSGNGQWFFGLAALNTYKELDKIQCEMKFVPTRFLISASTANRTITVTPVTDAWTENLDAKGKLRARAVSSMGVSYIVLSLYTSVVGNAFMENVHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA88</accession>
    <name>A0A6A6RA88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translin associated factor X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_577829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA88"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="32199" checksum="67D164F51546EF37" modified="2020-06-17" version="1">MEEPSKRQSISPVMAMFEGFRSELDEHHDRRERVIKASRDITAASKKIVRTLNKPLPAFVTKSNAQYWGIIQTQYKNISRDLQGLNAYRYGRNITGGNQEFMEALSFQHYLEHQNLISYKEAKNYVAKLGEEGGPVLLSTEDYILGIFDMVGELMRFAITAMATSGELPGTLIEKDLPSMGSHDEQSGDSMDVEQPSTTRPPHAQKRDVLADLRELRLCLEGLEPSRGSKFEGDAEKKMTVMRQCVEKVETALYGLIVRGQERPKGWIPDLREERRAPEAVEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAR8</accession>
    <name>A0A6A6RAR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_613388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAR8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17585" checksum="03796AA93FCDD099" modified="2020-06-17" version="1">MALTNTPNDAPPAYPDQEITPLPPPYVPALEYTSFPVLPSSPELRDQPSSMESLPPAYIPSSQSYDSFSDHSDLESGLSAADVLSTPTAAARFYVPRRRQALASAPPSSPESPSSSDTITTPRIRFRRCGGLLGLLLLVFAAYLICAAPMFRLWPYGSKVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAV2</accession>
    <name>A0A6A6RAV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Squalene synthase</fullName>
            <shortName evidence="19">SQS</shortName>
            <shortName evidence="19">SS</shortName>
            <ecNumber evidence="4 19">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_522500</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Squalene synthase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS). Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. The presence of a gene encoding a squalene synthase supports the identification of the cluster as being responsible for SQS1 production and suggests a likely mechanism for self-resistance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="19">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 19"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAV2"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC66</accession>
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                <person name="Bloem J."/>
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        </source>
    </evidence>
    <sequence length="488" mass="54526" checksum="989112C01F3EDD73" modified="2020-06-17" version="1">MSLINSLLGPLSPRGSPRLRSPSEASHELPFYSPPRSPNAPPAFPPPPIASSIYVSASPPAPKDRVPDDFLAVQRKARYIEEQLQHLLDSQAEGLMAAGLGGGPPDDQVSNGSSTPTVSSMRRDITSPDRRPARRKVSLTMARRGIYKRVQQMAAVKEEEAYLLDADMAKNKAVLERLGRWESKQRGIEKRIKAIENDQAGSRAQNLQAEAKTLESEIKQTEEKLWAMKARHRKILAELSETENSVEAKLSSYKTSLSLLEADVAKFLARPPSDANHSSRASAFYSLPPKRRTLAMARDHWEEERTRLEENWQEVDMDREALEEGAILWQDVYKRITDFETHLQEEMQGMGRGRTGSRDSPETANSSSKALIAQMDATVLYIETKLKLAEEKNWKLLICCIGAELEAFQQGRTILEKVLSQASPPTLQTDTDSDTSGQELVDLGEHREEQSAEPAARASTFRPQKYFDASDDDPDPELLISHHDTDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCY5</accession>
    <name>A0A6A6RCY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_448034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCY5"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2502252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="862" mass="95241" checksum="F52FC8E445080516" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE62</accession>
    <name>A0A6A6RE62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_475111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE62"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="284"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2502734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="587" mass="63705" checksum="797F153E0A0982E1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE77</accession>
    <name>A0A6A6RE77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE77"/>
    <dbReference type="OrthoDB" id="10676375at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="386" mass="42704" checksum="282962F2EC78988A" modified="2020-06-17" version="1">MCVIRGSFLPDRLSFERFTACFPHTGSADILGDHMAGHHAWLLFGGIYGAAMYAWLIPWDYEHLLKHVVVLELDNTQRPHVCEAQLHNFAHCTELRMVDVIMEHDEYNTRLMEQFEEFWGSDTADYQTAHLVLYTSATNRLLSTYRISSPPSYLPTGFLPSAAGSSPLPGLTPHRPHTPQGRDCDEGRAERLPTTPGAGHSESYFHTRCENTETASRCRADAETSSLPDPSTFITASVAGHAASYQEETPTGRDISPRDPSLPSLSLLIMWSRYAAARDSSEEPETDEQVDDGREARRESSHTDINAGEVIEGSEADEGLDLVQGVEYSDDEKADASVLSAEVENNGDEGTVVSVSTAAPGSVEDFNPQRRLTTKISATWEGRRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RER4</accession>
    <name>A0A6A6RER4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_533237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RER4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="137"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2502944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="557" mass="61683" checksum="AB2E2A2D78F39F5E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REU6</accession>
    <name>A0A6A6REU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_425806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REU6"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="471" mass="52182" checksum="2575B3BFDEAA4960" modified="2020-06-17" version="1" fragment="single">KNSEIIAHTRLTEALSGLQVNGECLSAKNVAALASPCFFHKKFDHAVNIDKVLDEITDDESISHSRLMQTATSVREVSKQLQRRPIKMKIRNVMIVTKARDNELVHLTRELTQWLLSTPRHGSDVGVNVYVDHKLRKSKRFGMDSILSQDPRFEKMLRFWTPDLCWTSPEKFDLVLTLGGDGTVLYTSWLFQRIVPPILSFSLGSLGFLTNFQFHQYQDSLNRIMGDAGMRVNLRMRFTCTVYRAQSNPQDGGPAHIEAEQFEVLNELVIDRGPSPYVSNLELYGDNALLTVVQADGCIFSTPTGSTAYSLSAGGSLVHPDIPAILLTPICPHTLSFRPMLLNDSMLLRVAVPRNSRATAYCAFDGKGRVELRQGDHVSIAASQYPFPTVLSQPTEWFDSISRTLRWNTRGAMQKAWDEGSAPELGAGKAGEEEKGFDIDIDDDADRDSGYSAEGSSAGGSASPVRRGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFC2</accession>
    <name>A0A6A6RFC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_532796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFC2"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="350" mass="40164" checksum="4818CC5EADCE5C0C" modified="2020-06-17" version="1">MPIGSRRRRAALKDSLNIPFEQLPYQCFQDARKVLQDDRQEKIKQIEVARLRIANLKAQDEAISGGKQAKENRLRSMHNRLEELKILADINDPVVKKKHEDGEGDMNKPIYRYLADKQWRQYRRKILEQRISQLNLVPDILPNLDPVAEVDLAFGRHKIPHGDFVDSLISENVPRLKVQVFDKGERLVTVVVVDPDVPIVQRDGFDYRCHFIASNIPISPTSTSIALNQLDLRVKDASAKHIALPWLPPTAHRGAPYHRLAVFLLRQADGKVIDTAKVGDSTKRDGFILRSFMDKQKLTPVGVTVFRTKWDENMAGVMQRAGLGDQVNMEFKRKRVEPLPYKKKDGARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG19</accession>
    <name>A0A6A6RG19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RG19"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="429" mass="48299" checksum="19C3A0028FC0ADD9" modified="2020-06-17" version="1">MEDDGLRTVQSMLATIGLDTGPPLGSHSPLERGELQGHHKRKWDPARQALFTAAGANNVVEQHMVDIRYLDQDSRSALLEGPLVQIMFSIPGQDAVFSTIENIPKRLLMAMSGTAQEAFQRNPESLRLSLSRADASPKAVRWVCAWLINSCLQEKAFMFNYREDWFSDVSVYQVMNTLQIRGSVAHIRRSFQSQISAGWLSYDQMTSLLSAITPNDPIFRHLAYKYSWLRYNQLIPDPDQFSRYLPIFPAFAQALDQIDKKMSDKRVRQTKETERERVDCRRAYSQARKHLQSQKSSPPHSQHTKLGTSRKDLQAGKQEIPYTSSSDSERILGKHIPKGPGDKQGPGQQQSTTASSHSEQAPGNHLHRGPGKSQSSRVEKSTTGRSGRKVGMDNHVQPDSGVEEKVRSEKQVVDTKHTPGFKILRIVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGH5</accession>
    <name>A0A6A6RGH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_19852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGH5"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004201">
        <property type="protein sequence ID" value="KAF2488750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8P3"/>
    <dbReference type="OrthoDB" id="4737581at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="73" mass="8367" checksum="4BEC3693C63BAFD2" modified="2020-06-17" version="1" fragment="single">SKRSKAQYEADGMPMISWPASSPDLNPIENLWKLIKERAEWDKITEEELEELIKSMPKRIQAVIAAQGGPTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8T3</accession>
    <name>A0A6A6Q8T3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">BU16DRAFT_531905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8T3"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="174"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="395"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="395"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2488858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="573" mass="63995" checksum="00FE864819E8A4BC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q900</accession>
    <name>A0A6A6Q900_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_532218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3534704at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025589974" evidence="2">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="208" mass="21595" checksum="20FB10A2CACC172B" modified="2020-06-17" version="1">MLLTEILAASAFLSTAAVAAPAPVPAPQIIYDPVLFCPIVDSSEEIAGDAWQIGLSVPGGDTISVTESHSVGTTWTVGADLGISAGGLSGGISASVSETVTDSVGEGTAAKCDEGAWHCSMAIVPSVAHVKGHLHEQDNDESCPVDRISQDDGGEEGKEFEFLIPIKDSSGNGKWTYDVCTCKNTDHWGDVGHPPLFCPEDCTPHDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9A7</accession>
    <name>A0A6A6Q9A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette transporter ABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_576001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2488594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="744"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="41"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="366"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="705"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2488594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1274" mass="140479" checksum="0274462BA76AE59E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9B4</accession>
    <name>A0A6A6Q9B4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_623408</name>
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    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9B4"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="54127" checksum="C4FF5123DCA2B22C" modified="2020-06-17" version="1">MIRPFGRRSCRNVSVVLIFSAIVALFFVKMSPLSNPLPSYSGEHQVGIIDVEADCETRVLHPAVFREGGEVALKLESVFFTLFYPATPNPIHSPPNHYWVPRPLSLTAAGYAHLAHVSSSLLRRVFTFGLWLFAGATTIPAHADAALLSRLEHELGGLRDGSAAGRPSLSLLAYGAGLPVVVFSHGMAGMRTSYSHYCGELASRGFVVAAIEHRDGSGPGSVVMKGEGGERDIVHFDREDVVSDPPITFEEFKAAQLAFREAEVEETIRVLRAINEGEGERVLQENPRAEGRGFADWEGRLDTDSVTMAGHSYGATLALQTLRDAPSKNLPIRSAIMFDPGKESGPLNSLITVPTLIINSGSWTSSPASFYGRPHFAVVKAVAQSVLDRGVHAWFLTLLHTAHPSITDAPILQPLLFRLVTGTRLNERLALDAYVGVSYDFLRFVRDGGRRGVLGSGVTSEDGPLGKVGERGVDESGLWEVHVAPEVEEEEGGEEWIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9D8</accession>
    <name>A0A6A6Q9D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_623193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9D8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="226" mass="26153" checksum="CE3604BF54AB819F" modified="2020-06-17" version="1">MSHLTVWSLFFDRISPAAKSRQPTGSSTEVPLFSRNNEPPRSLEHVPRDNEPPPRLEHVPCDNEPPPRLEHVPRDNEPPPRLEQVLRDNEPPPRLEQVLRDNEPPPRLEHVLCDNELPPRLEHVPRDNEPPPRLEHVLRYRRQRPSFDSPTASRSGLSDCRPTSLSRSSFHANTSTELPRDNEPPPRLEHVLRCRRQRPSLDSRPLHPPKFLCSLPTMSHLNKPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9I2</accession>
    <name>A0A6A6Q9I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_553327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9I2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="511" mass="57128" checksum="01B460872C24B2E1" modified="2020-06-17" version="1">MPPRRRFGFLQSAFLAKGWCPIPDVVTPLSDSLLSSDHFDEPGVLEMQVQRLSAAVRAPTESFDDNGEVDEDPRWTTFDDFHAILEELFPLIYSHYKPKKVNRYGLLYTFNGTDVTRKPLLLTAHQDVAPAGPTSGWTCLSFSPHFDGTFLWGRGSNDCKNLLVGILSALEDLISQDFTPKRTVGLAFGFDEESGGFRGAAKLAQALIAEWGIDSFEFLLDEGGMGAQEVGDVLYPLPAVAEKGYHDIELTLHTTGGHSSKPPPHPASEHPYVPRLTQSNPFRRVLECRATYSPSEVEPWLKEALQNGDEEEVATRLAESSHEERWLMQTSNALPETVMVLINHRIIPHESIEVVNQHVHDVLEPIAASYGIQIMGPSAHVSNSQNATSTGTLIFSFPRSLDLAPISPTNNQVWSVFAGTLRSVFQRPSSNSQKTHDRPRRVVPVGDIMTGNTDTQHYWSLTTNIYRFTPAREGSRVNTHWAVEKMRMDAHVEGIKVYYDSIRNFDEWNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA32</accession>
    <name>A0A6A6QA32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">BU16DRAFT_520633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA32"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="305" mass="33641" checksum="12A474E8A73A79D7" modified="2020-06-17" version="1">MPPPRLTSPLKALAKLPRPSTSSALRRLSHPLPSHKVVLPPQPHHASIRHSSTSSVDPTEVSHFNALASSWWDPHGPSRLLHLMNPLRHTFITRCLTSIPVPVSASHPKTYRYLDVGCGGGIFAESAARLPHTSSVTAIDPSSEVLAIAEAHKKRDPLLTTSGRLTYRNEGIEALPLPATEAEQFDIVTLFEVLEHVNSPSEFLEKLMPHVKPGGWLVLSTIARTWTSWAVTNVMAEDVLGIVPKGTHDWRKYVNEGEVRGWFGGREGWGEMRTMGVVYVPGLGWREVPGGEGWGNYFFGVRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA73</accession>
    <name>A0A6A6QA73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA73"/>
    <dbReference type="OrthoDB" id="10377442at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="395" mass="44113" checksum="31CB421F2EFD9A85" modified="2020-06-17" version="1">MKSETKPEAAASAATKSDIETDIKPEPEVSGSEAMPPKSNPSEQENGKGKKKKNGKGKEKATTESAMEDETKPEPAVSAATESTLEDVERFSTASEPVPTLDFFREGDNIRKRFQSFPKLEGRGVDTPGPRRKLCTPKFQKTLLNGLAEILSYYQLPSEKFSFKDRNNLLAISIVTIRETKRIKNCDALWVLPSHQKIFCDAAVPIYKQLCIMSLAWTRNTDFYPPKELFQRKDWKQYLASEEPRSQSSSYAQTLPAAAIAIRNQWLAAFEGVAAQSTRIKPGDSESTREWKNKLRESYEDALPDYDEGYLKTSLQGTEVREVESFDDTKSSGSSGYRSLYHLNQLANKYNPGLENVDFGPEDGEDKRTIDLVTWPKAPVPGDDDLGGFKGGDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA84</accession>
    <name>A0A6A6QA84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_219304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6QA84"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom"/>
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    </dbReference>
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        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
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        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF10">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2488959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="313" mass="33532" checksum="F30AD01A4349F63F" modified="2020-06-17" version="1">MAPTTTLKNIILAGATGSVGAPILKALLAEPSFNVSVLTRASSSSTFPPSIPTHAVSDAFTEAELTDAFRGHDAVVIATSTTPITKDDLAYRFVNAAVKAGVKRLIPSEFGANNLDPRAQKLVPVYKAKGDLLDYLKTKEAEGLSWTSISCGSWLDWALDPAKSGNFLKIDVANRKAEIWDSGNAQFTVTTSSNTGLAVAQALKNPALSANKQIFLSDFVTSPREIIAALESQTGEKFAIEEKVSGPVVKEARAKFDAGDYNSVYTLLSLSFVSDEDVGYNFAKEQKIWNKDLGLPAATLDEVIKATLEKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAH6</accession>
    <name>A0A6A6QAH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_567622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAH6"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="483" mass="50318" checksum="69E02FDADF502069" modified="2020-06-17" version="1">MLRLRATTSLDVVSQVGIQAASTTLSTLCSANCAPSVGLVTAVFWPETNVNSTLCGTTQTAGIPCVSLPTPFCEKDRATFVCGFSTSASAGPPATVVETTTTTPTSTPTSSPAFSTSPPAIVASTLTSGTTETSSSSTSSSTTFTNGNVTSPTNTPKPAKTHAVKSNGVTSGAAAGIAIGCLIAGAAIAALVFFFLFKRYKKRQQAQSAAYNHQLGPYNGTVAATPAEKSVPIATATAISPVDALLPQPAEDNAIIGELSIIRTKIKDHAQTYYHTAAVDPVMVDESEFQDVARATGIRSMALCDMLLNPRTRIATIRLFLSYAILSRCGGQGGAGASLLPPEVGLFADTLAGIDGSNAGQLALKSKWHSISATLLSSRYSSKTISDSDPRSHSIAATLTAVDGVLRPFVISPQDDAPRLRNLQSVIQRAASFAFLLFSQPSTFVFQWSAQGKLVVFPALLQTSDENARLLNPPRVFANMETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAV1</accession>
    <name>A0A6A6QAV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAV1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="35243" checksum="4346701B44B714A3" modified="2020-06-17" version="1">MERTRHTSPDDDVLLFDVEIRDSYEAKFADHQKLIQDKLAASQRLRSLRPNRAEIDAGLAEISSRDTSERLSKVMKVLQDFPGPWEPKRRKAADTTADTDEVMFDVGGEQVPLGEELHQQLAQASPTASRDQSPTKAGGKSQKKKEWPTLVPYNASSPDLLVPEGFQLMLLVKGDLETGEMRRFEELPDDTQLALLSILQPSFHAEGYSIFFKSDPKDVCLYRRMFTRMKASKWQKDDHDAVCENCIYARRPCVRLVSEGEKTKKGYATGGKLVFTPLLPKYRPGVERWEREEYWCLKEHISATRSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBH4</accession>
    <name>A0A6A6QBH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_567784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBH4"/>
    <dbReference type="OrthoDB" id="3798937at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="32051" checksum="973CCA23AF520CCD" modified="2020-06-17" version="1">MSYQTKIITPLYSFDICPQGKPTGSSRSSTLNSRKAPIFAVYRNEGHRVENNSIKTPTYLIENHVQPWLFRSQWTPLSLSENPQITSSYHDKTPTKQRRIMIQQRLFERFMCVKGSVRYTPSPEPSGSSVKPKLTSDEKELQLTNGLGHGQWRDSVLTKLLGRDMSKPLEWCASYNQWDGYDETYTGRFVKLAWDSRGRCVGGSLMLKSGQDILAIYKPRSSSWEKDGLEKVEDSHGMGSLGIMIDGVSGDALEHIILTCVAIEEQIMRSKGFGGSYHADWSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBJ8</accession>
    <name>A0A6A6QBJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_622951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBJ8"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="491" mass="55544" checksum="ED35074ECAA8081B" modified="2020-06-17" version="1">MPTRLKKQSKIAQTMDSVSSKIGGLACALCGKGFEKESSYKRHGYYCRSKQTGNPNSRKRSCTSCVRAKTRCDAQVPRCSKCEHSGIKCRYDKVTKRGSPASDSDILSTRSNSDSIATSQASKSPQALLVNKEEMLDGFMQLEDDGMSIDLAKWAPQIDPGFSIDMTFPNISEIFQPSVNDCIPPEGCIYLADPESLPFRPIVRRKMARSGSEMSSQFLIRIIRSYPEMMLRRETFPPFIHPQYRTSSGDIPETLANCMSVAQMFTTRTKESKNFMWRAIQMERDRVLTNLHQFDDRELWAGIQVFLIYTIMMEIDGELEKWSIHVPLLPAFKAISDAIGAQAFGDVTYDNPAANIAQSAPSPSVDEEQIWQDWLFEESKRRTHVLFKIIMMLIDIEGGLHCPRPSPVPEFMLAPLPCKKALWECRTSHEWRVEIDRSVQEREIFGLTETGELMVLREGYDGLKKSSASWEKWFAGVDGFGTLVMLTSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCQ4</accession>
    <name>A0A6A6QCQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_597465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCQ4"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="28526" checksum="5BCB98E764BAEEBE" modified="2020-06-17" version="1">MLIRPLLREDLPAVAPIVHDTFSNDELFTWLYPHQEKYPNDLRRFQLIRLRSRLVQLGSHGFVAESEAGDAEWNGAPEILGFAFYIREGNDEKAAKWRQDSIAKRLDRYLLSWEQWYEEKALDRASDPARAKMMHAATQYSFYSQLESYWYLGLLGVSPKHQRRGIGARLVAHGQKIAAEDKMPVTLEASVMGRGLYAKLGFLEIERLKIVDGLEGVAMLWEPEGTEGTWLVRGEGEKAKLKKKETESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCY3</accession>
    <name>A0A6A6QCY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_567215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCY3"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="211" mass="23334" checksum="774E5A63E8A34FF8" modified="2020-06-17" version="1">MNISGTLNVFRLIRDPALCLPHHTVSTFNHLPVPLSRAFAGKNGESKVDIRAVVLDKDNCFAVPHTDEVYKPYNDKFQELRKAYPGSRLLIVSNTAGTGSDLGYAQADILERNTGVKVLRHNTKKPGCRQEVLNYFRNAPDSGVTSVSQIAVVGDRLFTDVMMANLMGGHGFWVKDGVVEDKNLFARVEHKLAAFLMKRGYSAPNPQSGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDX9</accession>
    <name>A0A6A6QDX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_585508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDX9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="18703" checksum="B6AF64415EFBE170" modified="2020-06-17" version="1">MRRMRYFPTQPALCEAVVSFAVPDSRSGVQTCGLITARAARICHAARREGVLPGSVARGCEVRTSGLQAPCELALKPRDSIGMHYSASETSEALAVQEVHAMREWGARREVGWFRWTGARDWRPACVAGAVRVVLEVVVLRVGWATRARVGKKSDDDKTVGRDDGRGAAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE30</accession>
    <name>A0A6A6QE30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_167189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2489903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="237" mass="25702" checksum="B0F7042735CD89C9" modified="2020-06-17" version="1">MQGCKEYRRGKRANLFLLAVFRPARSPSVFLPLQLLTPPPPHHISGDQDVDPNAFMRSLLDLVGTTCNPKQFHVSTATRRHTPAVPLYNSLPISPSAFVGPAAEVGPPRRPVLQPVYKGVCEQHPPGPRPDDCCASGGPTLFLSSSPSSGCNYLRPRCQPPTSCSFLTSCADRVTLTATHPSECVDARLKGAPSHGPEGDSSPWANFTEIYRRHLHLSTTTVVRNFSVIVPGCRNAD</sequence>
</entry>
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    <accession>A0A6A6QED1</accession>
    <name>A0A6A6QED1_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2490394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="242" mass="26832" checksum="CFC03E3DC67B77C0" modified="2020-06-17" version="1">MQTSSGYKTFPFVASSSFLQRRREGFGGWFIKRQSETCHGVVVDSLPSAQSIHTSWVEAACAKSDNFDGDEVEGSEVCCEVFMEARWRRSGINSSHNLTLCSGVGESKAIDCIVDGGGIGVLFYLLSMIKSINMPSFHSLFEAFVASEKNIPREIVSTSIVIPRSCSHHCRVFDLVFQHEQQHPISEQLCLVAPTIDMLTGLTGVSFSRHSGTEHHRTTRTFYIVRTESAPTLHHSSPVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEE7</accession>
    <name>A0A6A6QEE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-dependent catalase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_552503</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004096">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="357" mass="41488" checksum="5160001AB4C49472" modified="2020-06-17" version="1">MADLSNRPYIHWNDPNVEKIPPNEAEDIQAVADMINLIQKTHYNKTRHAYGGTHARTQGVVKGTFVVPDDLPKHLKQTELFEKGGEYQCICRYSSEPGDPGLDDRIPQPRGFAMKLFDVHGKMFSGFDWPTQDIEFNSTPALDLADAKTTKEIIDLRINYGNDKPELYKHLEKREDTTLQKGRDGVRNTHLESTRQYSQTAYRFGDYVIKYCLVPSSETQKKMYDETVKPEDGDDILSRWLKSFHEDHDAEYLFQVQLCENLEDQPVEYAGKVWDPEKYPWQTVATLKIPKQDSFNYERKMFWEDHMRVDPWHGLISLQPLGGPNRLRRVVYPASSAMRRKLNGRKEFNVTSINDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGQ9</accession>
    <name>A0A6A6QGQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_543424</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGQ9"/>
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        <location>
            <begin position="47"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="190" mass="21464" checksum="7CE5FC0A050B6928" modified="2020-06-17" version="1">MSRRGSETAKKPDPELVAVIGDLQRGLEEKTRAIGEERAKQYHALREEYQRSHVTEENRGRSVDPAMDEAASEWSRSRLERKRSMTIGAPPLQRTHSKKQVPAVLRREASRNRSRTRVVDPAENEASFDAAIEPRLGKAGDGDGRSRERKRSTARAVIPGAPPRHRSTSRRKPEKKAGGDHHFDDIIDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH15</accession>
    <name>A0A6A6QH15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2426273at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24984" checksum="02A4B7A0D3CBD07C" modified="2020-06-17" version="1">MPQGVLFEFGTGSWVMSAPEERMHSKTVAAVLADIDFSCRILAAALDGRSGNGAGAYASLLLLLYRRMLEDEWCPFYVERMRFTLSIENQVRAFALGSVRCALDHSECNQSRCVQDRANGGYNPVHCVAGCECGLIRPPMENMIQVLKNGDIPVLALSDEEDDASKMRVYAAKDCSYVAISHVWADGLGNPEENAILRCQARRLHRHRLSYMEGGEDLEHTRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHG1</accession>
    <name>A0A6A6QHG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_585234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHG1"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="66"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="321" mass="36371" checksum="1FD3E2BDAE2B5C38" modified="2020-06-17" version="1">MHLTDIPRRLSKGLISPLIPLGPPPSHGYFPDGPSNPSVKPLPSRRKRALSLTCEENSDSDQVTFDQSQSPLYNKLPAEIRLLIWEAALGYSQIHVRPNPDDRKLEHMKCKDPSHSKQDCWRLFGWDRYTKLDFYDYGVPSLDGWSNVSPATEGLLALPLACRRIYSEAIPALYTLNTFSFAAFEPITAFSAAVLPHRFHSIQRLDIDVSFVFLKFDPTSSNWAGCNDKLIWERAWRVIASMKGLRELNVRLVDLCTSSNPMDLVSVLDADLEEDLWKPLKAVTRPKRFVVETSLGKNDSVELGDAPFTVVRLGEKRFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHN2</accession>
    <name>A0A6A6QHN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_565245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHN2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="143" mass="15187" checksum="3D10A8C310C314C9" modified="2020-06-17" version="1">MSATAEPSTTAALRKRLIAQTVISVASALPIGTLPGRRADPQPLQVQGLQAGLMSRAAATSFPHAYHERAEAHELPSELVIASSKGSEQLIVLKFLASVNGATAQGIRLSRGESWSMFLRVRQDAGSVNTHSMNRVAEIQETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI66</accession>
    <name>A0A6A6QI66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_565488</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI66"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="101"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2491789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="505" mass="54637" checksum="1A35DC9551073A4D" modified="2020-06-17" version="1">MAKVFDYAEVAKHNTAESCWVILYGNVYDVTEFIPDHPGGSKVILQLAGTDATEEYDPIHPPGILEETLKPENKLGTIDASTLPSSEKSPAQDTPEDSGPPDLESLLNLDEIEEVATKQISRKAWAYYYSAADDLASKSFNNTVYRQILLRPRVFVDCTACDTSTTLVGHKVSLPIYVSPAAMARLAHPDGEHGIAQACGLFGAMQLISNNASMTAEQIVADAQPGQLFGWQLYVQNDRAKSEAQLARIKKLDAIKFICLTLDAPVPGKREEDERSKNIGAILPVKSAVQGGESTSQTSTSPQTNFNPEIKPGGIGQSLFAGTAADLTWKTTLTWLAKHTDLPILLKGLQTHEDAYLASLHAPQVKGIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFNRIEVWVDGGIKRGTDVVKALCLGARGVGIGRPALFGLGAGGKEGVARVLEILKAETETCMRLLGVAKVEDLGMQYINTRSVERDIYDGPASLEKPSLWEKARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QII2</accession>
    <name>A0A6A6QII2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_564502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QII2"/>
    <dbReference type="OrthoDB" id="10646698at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="185" mass="21741" checksum="206CB392D41BAA7E" modified="2020-06-17" version="1">MRMLRYQPSGTVGFVVRVGEGTQDIYLFEGDTHHTTSLPICSCRSPMRQAYCDEPDAHYGILDNIRTCHYSPFGVFKCPNKWCAGHPWPQNPCYGEACVFFWHDGDAWEKTDETRDSVLQQAPETRRDKWMEDIDEMWSILRTEDWTVDGHYTVKLHRRMRQLTSMLKKRKENEERGRGMNDQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJH0</accession>
    <name>A0A6A6QJH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_492732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJH0"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="497" mass="53781" checksum="A8DB6F1D3C9BBE58" modified="2020-06-17" version="1">MAADLESAYEKPAMSEDGQQDQQSSEPDQTAIEQETKDNVVDWDGPDDPQNPRNWPAWKRMTQVVFAATFLLTANLAATMYAPGADALANEFHITSSTITSLTVSIYLAGFAVGPMVIAPLSELYGRLVIYHTCNVFYIGFIIGCALSKNTGMFLAFRFLAGCASSGPLTVGGGTVADVVPPAQRGKVMSVLFAGPLLGPVLGPIVGGFVSASIGWRWTFWIILILAGVSFTISTLFLRETNAAVLLGWKAARLRKETGNAALVSKMDRGLTPRQLFLRAISRPTKLLILSPIVLLLSLLCAFLFGLLFLLFTTFPTVFEEQYHFSAGVSGLSYLGVGLGMGVSLVVFATLSDKMQKALGDSPEPEGRLKPMMWVMPAVPVGIFWYGWAAEKQTHWIVPIIGTSFFGFGFLWVIMPTQLYMVDAFGPEAAASALAANAIVRLLFAAFIPLAGPPLYADLGLGWGNSVLGFIAVAFLPVPLLFYRYGGWLRERFAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJL0</accession>
    <name>A0A6A6QJL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_541440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJL0"/>
    <dbReference type="OrthoDB" id="3650883at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38000" checksum="90C984D3584DC849" modified="2020-06-17" version="1">MSASAPFPKSPSPVGSFRRQSLNLLNFAQHAPQRAKNNVDWINPAGPANKIRTPFPLFQSTVKSRNSKAEEVGDKEHRLEDLSSSNYLQFAILALPRELRDHIYSFVWPTETPEEIFLSLTHPPITPSLCRTSQQLRMETLPYFIQEQVFNVRASADLKDFREWLDGSSNKWNFNAYSAIRHLRFIEWSGRGSWLEGGNDGANFLKRCPNIRTLEINVPQDVNADEAPDTGFSYSAAWDVVRYFHNIGELMEYLHFGTVFQCEKLEKLTITATRADYMRVAAGIKFQFWFLKGFHKLGRNVNVNRRVITGDSYPSTARITYLGVKTNYSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJQ0</accession>
    <name>A0A6A6QJQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_593720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJQ0"/>
    <dbReference type="OrthoDB" id="3764174at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="247" mass="28735" checksum="5C61AAAEB52A48A9" modified="2020-06-17" version="1">MDRPLIILPDYLQEEVSHLPNMNELFEMEESVRPCTWGSLYHILRCGHKVRTTTSERCAENCRIFWNETDFAYPRCIEKELRSIIAAGGAMDIPDEDIIEDIKFAIEAEIVASRKRVATTVMYRDPIEDFYRDNFPELVEADTLMETTQMEDVQRKFLRTSARAQPWNPEIWQRYHRNHVADAPNPTRRYTLAPVPADNLMDSLTKDFQSFDTVVQDDEHNAQVDEIGDLFGRLEAKDSEPDVNMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJW8</accession>
    <name>A0A6A6QJW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_490411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJW8"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="203" mass="20978" checksum="AD7545FF959780B2" modified="2020-06-17" version="1">MNKLKSLLHKKDKSASTPSNSSPATQTSSSAAPTSGAGTGAGAGTSADAEGVILHTNLGDITIALYKDQTPKTCRNFAQLASSGYYNGVIFHRIIPGFMIQGGDPTGTGRGGESIYGGKFADEFVSSLKHTDKGTMSMANSGPGTNGSQFFITLGPTPHLDGKHTVFGHVVDGMDTVDKLGAVRTNAQDRPVQDVMIVGGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK25</accession>
    <name>A0A6A6QK25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK25"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="35697" checksum="CD4A1DF808FAAB6A" modified="2020-06-17" version="1">MLSLPLITPRDDSTLWPSHPTSRLSSLDSPVSSSTDPNNAPPPHHQQQRRPHSHHTHAGSTRSTLASLAADENSILQRKQNVRRFGAGWIRPPGVPKTYQATMDEAAEREEQEILARREQALADMAALQEAEELAAQREAGEEEGDGDEEERDLDDEVPEAEAEDSDEVQSTSEMGSEDGLEQTEAEMTFNEDSFIEGSMVQADVEQMLEMEEADMAGVLQDERDLDDDVPEAGSYQHTDTELEDESSEMEEMSFEGRRSGINRPQSGRRLGARSGAAARTSMFSEDGSSMMGGSSFVGSSPAAARGPGLGNAFRNRLMRPPPPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKL7</accession>
    <name>A0A6A6QKL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_551470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKL7"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2492584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="493" mass="56567" checksum="0EC3505261C3526A" modified="2020-06-17" version="1">MYFLTGVVLLLSYGLYRVLSIGRRHPRMPPGPPTIPLLGNAHQIPKTGLGKQFRTWADKYGPIFSLKIGPRNLVVVCDRKAANALLDKKGSIYSDRPFVYVTNYITHGDRLTMENATPAWREQRAIVSRNLSPKLLDEKHFRVQEAEAVIFMNNILKQPERMFDYARLYTASVASTLIWGQRTPDLESFWYKDFYELMDLWVQIEELGANPPIDEFPFLKYLPGNWKTRADKCQKLQTAMWTKARAIIDKRRSEGDKRDCFIDTKLDDYEAKGFPMSQHAFNYLFGVLLEAGADTTANQILTIILALAKYPEVAKRARKEIDAVCGKDRAPLFSDFNALPYINCIVKEGMRWRPTASAGLPHLCTQDDEYEGMLIPKGTTVFLGVWAMHYDEKQYPNPNDFNPDRYLGYPKLAHDYSRNMWRITAKLLWAFDISEPVDPVTGKVTSLDVDAYNSAVLLCPLPFKVKVVPRSKEHLAVIERELDDATKFMSQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL53</accession>
    <name>A0A6A6QL53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL53"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="92" mass="9675" checksum="2B98A86B40941350" modified="2020-06-17" version="1" fragment="single">MSSDATAVPLMQQSQAGATGQKEYQDCLPCRVMGGGVFVGLGAFTYLNGHSQLRQQQATILKSGSMFGMKSRQAGITGLAATFVGLGIYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMS1</accession>
    <name>A0A6A6QMS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMS1"/>
    <dbReference type="OrthoDB" id="10523414at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025456286" description="CBM1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32771" checksum="81A1C7AD18208731" modified="2020-06-17" version="1">MRTPITLAAAFVMALIWTTVLSQTTSVTSLFIPDYAIDAPSLASVVTSHDSTIVYDMSSSRLTFGPGFVEIHYTEEPVFSQSIYCDTRSVTEADCTLSFGGTDYPTTESEYPLTLSFGADPLANRAVTITAGLEKLGMKTVTTSWKKLGMGSSATPAPFPTAPSSLPTSTPACAGFLKCGIACCRDGYYCQDVYKNKCDLLPSFTWLQFSTTTQTASSPTHDGKISSTLASPALSKLSSNLNATAELTTILRTESNTPPTETHLRLTTSTAQGLSSMPATVTHVLGAGGRHFTIAVPAAGIAGLLLAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMW7</accession>
    <name>A0A6A6QMW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_563505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMW7"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="245" mass="27891" checksum="376F8EA96CCFBA8A" modified="2020-06-17" version="1">MADTSVVKACNSGTVLVPNCTDTNPVLFLQASQQPASTFLDLPSELRLQIFRYAFDPGDLISIRRNPAVLTSNSFKNDTRFANRSLRLATICRAVSQEVVEAYYSSDALPLKVEWAEYFSQTKQLLLPPRHVRRFVRRIAFYNSTENFWHSVIGQGQSLAPLQRLEELGFTHLKSVYVVIGDGTAEIINLCFQEPRRERSKLERLDETRQAFGGLRVRADSVSIFGLERHPEFTSELEKAVTLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN26</accession>
    <name>A0A6A6QN26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="300" mass="33337" checksum="C4C72F9BDCD37FB5" modified="2020-06-17" version="1">MASTGGRAAISSLASRSPAFIYGTAWKKDNTTKLVKEALAAGFRAVDTAAQPRHYREELVGNALRDVYKDGVIRREDIFLQTKYTTPAGQDRTNMPYNAADSLQKQIETSVASSLRNLRPSDDSEAGSYIDCLLMHSPLPTLTQTLDAWYVLEAFVPEKIQSLGISNVDLETLEHIHENSRVKLSVVQNRFYPATGHDVELRAFCKENDIIYESFWTLTGNPKLLGCNEVATIAKSAGVTTPIALYSLVMDLDIVVLNGTSSLQHMREDLEGVEAVKAWARSNQSEWEAVFKKFKSRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQN9</accession>
    <name>A0A6A6QQN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_562348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQN9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="179"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="331" mass="37687" checksum="6D53B8BD0BC3A27C" modified="2020-06-17" version="1">MATNTSSYKLNHSMQGLSLLDLLRTIRVKDPKISVKFYELLGMKLINKIENADAKFDLYFLAYDTPKAANHGNHWTDREGLIELTHNYGTENDPNYKIANGNSDPHKGFGHTCISVDNIQAACKRLEDAGVKFQKKLADGKMHHIAFALDPDSYWVEIIGQKPVEETESVTETDVETYRMNHTMIRVKDPEISLKFYQDVMGMDLKRVTERTAGGFNLYFLGYGAPAVQVADGHNPVADREGILELTWNYGTEKDPNFNYHDGNAEPQGFGHICISVDDLDSACARFEEKKVNWKKRLTDGRMKNIAFVLDPDGYWIEVVQNEKLKNRSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQS2</accession>
    <name>A0A6A6QQS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_527594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQS2"/>
    <dbReference type="OrthoDB" id="3939134at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="821" mass="91682" checksum="77D10937FC8F0550" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR65</accession>
    <name>A0A6A6QR65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_540127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR65"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="212" mass="23884" checksum="6082C6ACFE47300A" modified="2020-06-17" version="1">MGCLSGITAFLSCHSGDREVIKKAKRRRKEAKRQHRAACDERLAVAFARPEDYQQPASDLYRRIYREATSEARYDAQRDSYLANRERNSTATEFHVNEAWLDDQDRRANSHRHYLNSARPRGHVHTSSSSSGWGGNGAYGFASARIPDQECICPVHGRSSGSGSTLHHWQGYDARYARREGVRSCPHGVSYPVSPSRGYGEHAPGCRWSAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRL3</accession>
    <name>A0A6A6QRL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_461659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRL3"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="171"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="38478" checksum="36CFC8EEEB4A9462" modified="2020-06-17" version="1">MPSSFSSIPTINYSRLRTPTTKAAELIKLRDAIFVVGFLYLVESGLEPLIKETHEALPWVFSLPTEVKEKSNMRNSPAFLGYTQLGSETTAAQTDLREQFDFGTPVEATTAVNEPQWKKLAGPSQFPANSEVESLVKQYLTGMHSLSRSFLQLVGESLSLPPTTFDGFLGDMDRLKFVKYPPAAPGSQGVGPHKDSTGLFTFLSQDNVGGLEVLNKDGDWIEVSPVEGSLVVNIQQGFEAITGGICGATTHRVIAPTDVTRYSIPFFLGVRLDLTLDQLRESAAHITAKIPVTDDRKKRAVDVPSEFLSPQYSCFGEAQLRNRVLSHPDVGKRWYPDLYEKYSNEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRL6</accession>
    <name>A0A6A6QRL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_527522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRL6"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="319" mass="34284" checksum="C8797BDA8DC739D2" modified="2020-06-17" version="1">MANRSNRPSALNAPSAAAPSPEVDISGTGASSKVTARLPSGESVEVLLYGATVISWKSDGGKVENLWVSDAAKLDGTKAVRGGVPVVFPVFGPPPKDHATSALPQHGFARTSRWEFLGKSSSEDALDASSVKLDFGLYSSNLSDEAKKAWPYDFGIVYSVTLSKEGLQTVVNVRNEGTKVFEFQLLLHTYLRVKDISKTTVTGLAGVPYVDKVLDATTHTQSSPTLAITGEVDRVYASIPQNTTTVLEDGKPRFDVVRDNLDDTVVWNPWKEKAAAMGDFEPKDGFKEMLCVEVGSVQGWQKLESGDGFEGGQLIKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS02</accession>
    <name>A0A6A6QS02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_562563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS02"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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    </dbReference>
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        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="457" mass="50847" checksum="9608DBFCF81C15B3" modified="2020-06-17" version="1">MEDRIRQMESVITAAIASSENSSKLNTASTTTFEAQAEKFDTHSFVVNGDTSFQFVGVCFSLLMLQGSSNPLSIETLVAMAARISHAIGLNRWLDDCGLSERQLDERWNVSWMLYILDKDIALHAGRPPVMHDQDIGVALPKSMNAPLMMPSGLPHFYTFVYAAKLAMIESRVYSELYSARARSTPALQKLKAIGTLDAELQKWRTEIPIHQFLPVLALHYSYYNCLNTIHRASIHYGRWSELAEERELVKHDLGLNPRVYDSESICVIATRDAINLLDHFKQSPAPPMFWMSVSQPLGASLALFANILQYPDEPFAQSDLNLISSVTSLFGHLVAQGRLQFATGTLWIFRELYQIAKLYLSAPEARVVDPVSYAMILESSVSEGPRCVVDPRLRSSLSSVDEGVNLAGAELNIPTTVAANSCSDFNTQGQFSSHSYVDTNDDVLLDDVLFSPINIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS32</accession>
    <name>A0A6A6QS32_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_527887</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2494966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="71" mass="8011" checksum="153A62FDB35D9061" modified="2020-06-17" version="1">MRTRLISARVAGWALPSLPTQLQFPHPIIPRFLLPESQSEYDEHHPHEPDLQACEIRLPKSEIVALPAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSZ3</accession>
    <name>A0A6A6QSZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_510031</name>
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    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>FAD</name>
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        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
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        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
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            <end position="284"/>
        </location>
    </feature>
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        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="604" mass="65325" checksum="4D5D7559AA234FE1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT01</accession>
    <name>A0A6A6QT01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_385013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="270"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="444" mass="49671" checksum="406F13455E6A66C6" modified="2020-06-17" version="1">MYISLRRLRAAAAYSAIALSAVQAQNVIDQLSFGNKGGQLSPDGRGIQGWKVSGEGHTPNLMSDRIILTPPYPGNMRGAVWSNNPTPYSEWTAEFRYRASGPERGGGNLQIWYSKDGQQSVGMSSLYTAPAFDGLVMVVDQYKGMGGSVRGFLNDGTVTYKDHHSVDSLSFGQCNYPYRNMGRFSTIQLKQTADYFQVTIDKNPCFRTDKVRLPAGYYFGVSAASAENPDSFEAQSFEVSVPNGAQQQQGRTEPPPPREQYQQYPPPPQQQQQKYQAPPSDDIPQQLSDQLAANIKNQQDQFADLHNRLQIVNHQVNNIFQLLENLAKQQDQRHQEVMNRAIPTHDRVDAISRNVEKVERIVLAIQRDVEGKDYQQHLTDLQNAIKVTQTSLTEGLPLAMSSIVTGAKPRMGLIICVFVAVQIMVIGAWQVYKKRRNSAPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="KAF2495356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="99" mass="10881" checksum="E0FAEE784AB5A6C4" modified="2020-06-17" version="1">MTPKTSLALPAAAESAVSCSSTAPHALVPKPARLRFPDSHRRLHLNSRRLPKAALTDSERLLWCSHNPLKFMPSVTECRSRSRLAPPDTALASRMAHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTG7</accession>
    <name>A0A6A6QTG7_9PEZI</name>
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        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="313" mass="34367" checksum="2A8A3E234039304C" modified="2020-06-17" version="1">MGCGSCLMVTLRLFQALCAITMLALGVWINDTVTSAREKGDDVINAIFEDPDREKLVRNFFDSLLQTPKRVWFTIGAGTWTLLYLLLLTTTHLISRRRTRKTQSIPTSYTPPPSTSNSTPKRLHPLPTPLHLSLDLLTTFLLAAAFAAVASLALSLEPVCIALDFVAPETLAFVKVCPISKVEAVMSGLTWLLFAFTSVSLVVKHCCGCVKRRRDRRTKRVNFDPAASTAGMVPRMGYAAVPAPHVYAGDHLGQPMEVGREGDVRYDPYSPIDGRGKRGFVEVRVAEDEGGRKGEKEKRGLFGIMGMKGGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTH9</accession>
    <name>A0A6A6QTH9_9PEZI</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTH9"/>
    <dbReference type="OrthoDB" id="10453360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="197" mass="22562" checksum="82078F108C48793B" modified="2020-06-17" version="1">MYLRPFHSSATTLTTTQPYRTCITCGTYYTTDGPAAAFYDSIGRHDLPPLLCNCPPCAKAELHDTVALWDRAQKRGVGPALLERKILLRVQWNMYEKRRESVEVEEVDEVDCAKGVLVLEPEPPCGKIELGIRRVRRRAGGLWSGYWWRRTAPCAWSKRLLSRQLSVPFENDTRHNVLLSFIARKHFVDATFSYNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTQ7</accession>
    <name>A0A6A6QTQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch repeat protein-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_393241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTQ7"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2495569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="87706" checksum="3DC171460459EFCC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTX1</accession>
    <name>A0A6A6QTX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_393771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTX1"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057215">
        <property type="entry name" value="DUF7893"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF54">
        <property type="entry name" value="DNA METHYLTRANSFERASE DIM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25423">
        <property type="entry name" value="DUF7893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="323"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="465"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2495582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137362" checksum="D1D6122D7F9479C6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUW3</accession>
    <name>A0A6A6QUW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_485869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUW3"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496298.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    <sequence length="552" mass="59952" checksum="6F3FEB5D28EA4FFF" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </location>
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        </location>
        <ligand>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496039.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="232" mass="26136" checksum="0504277AEACB9D6E" modified="2020-06-17" version="1">MSDLDATTPRVFLARHGETEWTKNGRFTGATELDLTPAGVDQVASTAALLVGPGKLIDPARVVRIFVSPRKRTKQTFKHLFGSSEITITHDRVTLTEDITEWDYGDYEGLLEGQIRADRAERGLDKEKRWDIWRDGCEGGETGQQVTERLDRSISTIRDIQRPHMHGEMAADVVLVAHGLILRCFVKRWLGYPLDMPLQMMLSPGAIGILSYKKHDIEEPAFFIGMSIPFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496295.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="102" mass="10798" checksum="B9F0A37897C347E1" modified="2020-06-17" version="1">MGPSRSASPSASRPNSARLGRLLLSIRCATVAGPLRARSYAPPRGTQRLPNGSERPRAACWYQSPSYLAAAKPRAAAVLPNQPATDGELLHASSPVPPRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QV98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="219"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QVT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVT3"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="489" mass="54342" checksum="4DCE2EE8D560AD02" modified="2020-06-17" version="1">MPKAPKSPGGRDSQRHNPLTEDYLSSQPLKQKSGKRKKNAKDDESERFVDSKSSRKILRIGQDLVDEDEQEQNARKVPAANPAFAFDTRFDGEEEVEEEVGEYDDDEAWGDEEEEVEEVEIDPSDLETFNRFIPTDDNPIVWPGQEAEQSSGPGTNLADLILQKIADAEAGRGEEREIMGGGDPDDAIELPAKVVEVYSKIGMMLARFKSGKLPKPFKILPTLPAWETLISITRPEEWTPNAVYAATRVFVSSKPHIAQEFLTMILLPAVQDDIRETHKLNVHLFNALKKALYKPSAFFKGVIFPLLKDGMCTQREAQIISSVLTRVSVPVLHSAAALHRLCEMAAEQMSSDPDSAGPVNMFIRALLEKKYALPYKVVDALVFHFLRFRAATGGNANGDAMAIDSEEAIGGVAKLPVIWHQCLLAFAQRYRNDITEDQREALLDLLLTRGHYKIGPEVRRELLAGRGRGVMIEPEVGMGGDDTMMAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW64</accession>
    <name>A0A6A6QW64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_538992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="33559" checksum="7D486EE1E912175D" modified="2020-06-17" version="1">MASTFPCTAADEPSQIDTIIADRSIHSFAIPQDPCFPAYSIIASYMTGFLALAATVTSLATPIDHAYTHPLIPTARTALPEPSAAGTSLDAFDPAWLASAEMLPWELWYAVLHHARRNSWRDTVSHSALIWEPGVVWSELHMLGPSLIESFGAPAIYAPGDAEKISVPQTHAWTNVGGFVARLAAAGVWGVQFGVRFLKGPKWTLGQKAKVIMSNTGVGKGRHLDCEMPAAAVWMILAGELVWERRVAGWREEVELEGRFSGERWERWKGDFESVSRRGDVAVETREMAREAFQRMEELERGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWI2</accession>
    <name>A0A6A6QWI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWI2"/>
    <dbReference type="OrthoDB" id="3800763at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="397" mass="43203" checksum="316D790FD9549E16" modified="2020-06-17" version="1">MDFEERTNLLTICFAYKTKAQVLEYLERVPYPWAERAIAIVEERGRDRFEGNLAAHLALIPNRNSTEGISKKMDMSKAGGVEPTSVARQTRFGRVPAPSGESEAVSRSDAGSNDQPASSIASTHVGGATPSPEDLNPQPTHPIRATRSTQKLVSPPANANATASDIASRLFPTNPVGQPTPAPRTTPASPPPAPIFIIPTLSAGYPAHSVFVYARLVPLPALTTEAILAHPSFRQLYLGQDLMKATKPVLPHSVMVDKDRAKQYNALLSHLALGRDILYSWANNPVLCRNSKKAGYQLDDIQDWIEVIRTGREERMRELSGNGGAAGNGSAERRNVTFAQVLERVRIIEARDEGEEDEECDEDEYGGDAVATGDEIEWGVEPELEMEGVVPAGEAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX70</accession>
    <name>A0A6A6QX70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_484168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX70"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="530" mass="58158" checksum="541BEE132960760D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXM1</accession>
    <name>A0A6A6QXM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_560137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXM1"/>
    <dbReference type="OrthoDB" id="3694634at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="28062" checksum="9183FF050935F8B1" modified="2020-06-17" version="1">MASSGLFLLSQPLPPNTLSLGQLLPNPLSPSSGPFFSASTLGAQDLRKPHIQARYKDLVAFDDEGRLAASLSGRKVDPSRKDLVLLLADEMEYRSLQPNSAFDNICQDPAALSWMRSMAAQNQTLYFVVGLQELKNATFKSAVIQEGPLGVSVTEGPTAPKTSLPLHVRRDSSMDITDSSSTGVYGFEVRKVQCRLGRTDEPHLLEDLDLSWNYHRTGDGDLQLSIGMSKALQAEELRLLAAAMEDASDASYNSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXR5</accession>
    <name>A0A6A6QXR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_617031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXR5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25192" checksum="AAB8C20C8381AFED" modified="2020-06-17" version="1">MRMPLTGPIYSKYDSLSERELHHELRRNPNATLIILLIVTAVVASTLGFYAGRNSIKATDEGLLLPPGKVHQVWHHNETFSQKPTPQSEAAWNSLAPIGRGFVYHPVVSPIVSGITVFHQLHCVHGLRLAYYIITHQLESLNGSHTNDTFLNTIAARTNIGHIRHCFDYLRQSIMCAADTNFETVDQEHHTVNGWGSERQCRDYGEVVRWAELWRNDSSSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYU1</accession>
    <name>A0A6A6QYU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_484863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYU1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="41556" checksum="81257214E10622A8" modified="2020-06-17" version="1">MAAAIQTPPIPTSRNDLSTFDEARKGAYAYLQSRLTHKPAASNEPFEIPVIDISSSFSSSLLDRQAVADKICAACTTSGFFYITNHGVPLPTCATMLGEAKRFFKSLNPEQKELMHLRNSKVGMGWEPKAYTSIAGDTETKEGFNFGYEAALDKTGGDGLYRNIDGTNVKGNQWPREEELPGFFENMREYYSELLQLARHLFRLFALSLALPEDHFDSMTTHPGGTVRLLYYPPAKTPSPFSSSNSASSEIGLGAHSDYECFTLLLCSASSGLEILSPSAKWTPAPPVPGSFIVNVADFMMRFTNGVYKSTVHRVVNRAAEERYSVPFFFSVNYDQVVETLPSCVSEENPAKFPPIRAGEYVLQRFSNTTEGGGGYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZE3</accession>
    <name>A0A6A6QZE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_320340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Bloem J."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="39022" checksum="50754927C8584E5B" modified="2020-06-17" version="1">MSLKNLLKKKDKIKDEGTAPAASPTLSPNVPEFTFMRTTTTTQEEIAPPIFPGDAPPQQTPEAHRDHKRLSGRFRRHSNAAQNQSLDEGKKGDRRLSERLHLSRERSSSSVNVPEDLPTIDNTVAKTAEDEANWEKRATLLAKGNSVSRHSSEAALGEGGRGPPQGKRSRSVSVSDAGGDVNIQEAIRLHEAGEYDQSTVMFGKLADPNGANNALSQVLYGLALRHAWGCTKNEELAVTYLSYAASNSADVESLALAAGMKKGGAAKGELTLAIFELGNCFRNGWGAKKDPVAAKQYYETAANLGDTDAMNEVAWCYLEGFGCKKDKFKAAQFLRLAESKGSKIVGNTWIWKDKYNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1R2</accession>
    <name>A0A6A6R1R2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_604914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1R2"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="59"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="29313" checksum="B0DB36E72F792B77" modified="2020-06-17" version="1">MAPSQPKPLPAPESSLSAAKGRAQKNVFPPLKLHRNRLVNLNAPKNDARMIIAKRNSVESPLLRLPMEIRGMIWKYACGGNHIHITKTSLPGTSIKFFNSAYPHPENHESFCGVEEPGHYCRFYATNLHITNVQRTCRQIYDETWSYPYALNQFSFRSSVVLFEWLKQRSAIQKCAIERLWLDLFHRSHFSVSWTRGLSGLKVVKVYCKVLRLDDENWQAKGVYNGWLDSETVRAMEVLDKYLPKGCDIKFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R213</accession>
    <name>A0A6A6R213_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_615576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R213"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="106" mass="12103" checksum="678AA0EBF1CC90BB" modified="2020-06-17" version="1">MDERWDHQGFTFDDASTQLPRLLRNHNHSQTARMPIIPRSSYYDKNYKQSAALIRARQPFLLKNIATGAAIFAFTISVYAFTIKAVSQDEFSDVKVPDKPTEPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R276</accession>
    <name>A0A6A6R276_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_579855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5352492at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052159">
        <property type="entry name" value="Competence_DNA_uptake"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30619">
        <property type="entry name" value="DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30619:SF1">
        <property type="entry name" value="RECOMBINATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="1541"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="2303" mass="252090" checksum="17B9ADFAED1C3F59" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R293</accession>
    <name>A0A6A6R293_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_437867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R293"/>
    <dbReference type="OrthoDB" id="120613at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025487454" description="Chitin-binding type-4 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="212" mass="22300" checksum="3EA5F7F5E8001C01" modified="2020-06-17" version="1" fragment="single">MHSFTPLLTLAYLATTAYSHGFVTTPPARLAGTAMSAACGAQVYSNQASDNYGNVQGELQVAASQSDYNAAACDIWLCKGYKYADNTANVQSYTAGQTVAMVVDIRAPHTGTANVSIVDTKTNEIIGSPLIHWDVYATNSIPLSEQANNTNFKIEIPSDLGSKCATAGDCVIQWWWDARSIDQTYEACVDFTVGGSGSTPASSSSVVAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R319</accession>
    <name>A0A6A6R319_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_548373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R319"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1060"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="391"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1195" mass="134251" checksum="DC25BFEC8DD5CD78" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3H3</accession>
    <name>A0A6A6R3H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_481988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3H3"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="40661" checksum="565E90E21DCF125C" modified="2020-06-17" version="1" fragment="single">MASGPAVPETRVLAIASHVVYGYVGNKMVSFVLMSLGCNVSAINTVNYSNHTGYKQVKGTKTTAEQIQDLYDGLKQSDLNNFDVLLSGYLPSADAVQTVGKIGRELKFNAGTKPGSFFWVLDPVMGDEGRLYIPEDEVPQYKNLLREADLILPNQFEAELLSDTKITDLTSLGTAIQILHRTYQVPHIIITSLVLSATNKTLPSRPPSRMHNWPTSESNPSPQQEPEEEEYPNTLTIIGSTATSTHTARLFRIDVPAHSLYFSGTGDMFAALTVARLREATVAANLQNTASWKSPDDVAAAHLPLAQATSKVLASMQAVLAKTAAACAVEMEAYDERVELEGVGSGEEADQERKRKRGLRLSRAAEVRVVRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4J9</accession>
    <name>A0A6A6R4J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_536847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4J9"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="101" mass="11190" checksum="ED69858E6EB7FEA4" modified="2020-06-17" version="1">MAPTIGETHQNTFPRFDDGDVELRLSRLPSHVYVLHSVVLALHSPFFKASLSERWANNGDTAVIAPGSKIAWKYQLKFSDDDSAILTRDTGSTSEETRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5J7</accession>
    <name>A0A6A6R5J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_453839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5J7"/>
    <dbReference type="OrthoDB" id="5232980at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="228" mass="25920" checksum="C0E1BBF8CC098C45" modified="2020-06-17" version="1">MPVLLEYLTIEEEAQIYQQFEGICQPNSQVLWSGVPYGVAQKWADEHDMQTLTTAMGPLMDKADSLCLKKSKNGPQWSKYIKGASAVFAWYISSGEKVTTLSPPPPERFHPSGMTNYQAIEEPILKWAIADRAILRIEMVHPTVKGAENFSYQMWPIDEMKNWVAAFGTVAIKKNRWRVMGKVLHQMAIRKSITTNEKSDVGHSTSHYSQESELGMRMPIVREQKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5X0</accession>
    <name>A0A6A6R5X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_579910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5X0"/>
    <dbReference type="OrthoDB" id="5422613at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52926" checksum="7D8AB330EF26FB53" modified="2020-06-17" version="1">MFWSLSSSTSRLLSSMFFSCDSQLGRSRLAMASSTEPIDLTTERNLEPALLEVIGSAKAATLRQILIKVCMKSEVGSSLVREAILVPEDVDTTATASSATKKRKLDKPVARFAHCVQCEKDFDVTLNVQPGQERTCRRHDGTAECWNWMETRFQMMTILTMAMFLTSTLTGESVHFHSTSRGPAVSRRVGKQLSVCAVDTPFHILAKVRVLCIIGLDWGDIRLKITDGMRDEKEYKASLIWGYYVTRPDASFVYFDIIPLHNTPPPIDHSKYQSITFKMAAGPELIDAISSAQVSTLRSVLFHLCKDSSTASKVEQVLLVSSNELQNDAVKASMATNSKKRKHDDKISRFACCVNCKKDFDVVLNEKPGEEQACGYHDGSLEIDTDFFADDDEVAQDPYSIDVDTDWRVKEYPEGFQWSCCEQDGREAKPCVRCRHSQTVFNHESGGSLWYLGKDGTYTVDDNRNDGDGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R612</accession>
    <name>A0A6A6R612_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R612"/>
    <dbReference type="OrthoDB" id="3821346at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025683844" evidence="1">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="98" mass="11165" checksum="76BCB1A75885FA64" modified="2020-06-17" version="1">MPHGIVSCNVVRTIISTCDIFVLAIGLLEPCQATGMNPEQALDAMAPWLIDAEIFWERMFGMARRLHDYRTQSWQMMRGRDACEWKGWDWGCGGDADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6G0</accession>
    <name>A0A6A6R6G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_233533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2499992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6G0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025678276" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12598" checksum="FF0A6CAABD289DC3" modified="2020-06-17" version="1">MASKNWMFVWTVTFTWIHICFRLCIVSTSHSGTKNPPLAKRPAIAIPSAANATSHLYHIATYRAVPKCLKECPNHQNLTSQALPSTPRTSPTHSPTYLFKRRSSELAQLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6J4</accession>
    <name>A0A6A6R6J4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_547070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6J4"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF2">
        <property type="entry name" value="ALDOSE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="272" mass="29574" checksum="AC3E8B7E7EF5A143" modified="2020-06-17" version="1">MVMRAFGAHFPARVTQLPGLGEDGKYTLSADGIRAQFIPYAATLTNLSVKDKNGIERDIVLGYDNASYYPVDSSHPVYNGIPGPYVNRIGNGTFTPVRASVTYTLSKNKWSIKIEAASLKIVNIPLDAVDDFYSAPHQLGFADSTPAFVGHCGGGGSCDGYNGEWLVDAHTPDSAVKLTLASEWSGIKADLRTDQEGLVVYTCFWSDGSAQIKAGQGYEGGPRNITSGDCVAIEAQDWVDGINHPEWGRLDRQIWGPGERYSWEAEWEFGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6L1</accession>
    <name>A0A6A6R6L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_523027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6L1"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2500219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="116" mass="12928" checksum="5CA9BA89CEAF34AD" modified="2020-06-17" version="1">MSREMALQAYRHLLRSTRIAFQGDINTLSAARFEARRQFDSNRSISSGSEDAVGKIAQAQEIAKFLRENVVQGEKTDAEAENYKLRIHEHTERGNNDDIKTAGKGNTLAGVKCCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6N8</accession>
    <name>A0A6A6R6N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin-specific chaperone c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_522911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6N8"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tubulin-specific chaperone c, putative"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-CAP_CF_C-like"/>
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        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
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        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="168"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="39215" checksum="3748E62F784B1BFA" modified="2020-06-17" version="1">MTSQPQTEVGLKERFFRYFQHEVTALQEQMERLSSTALAGGERNDAVDHCLAGIARLSHEVKDASSYIPAYDQRTYAEAIKALNDKLQKTRLAFAPRSKFAFKTAHKNPSAISLSSAAELAAQKTPRVPGYPSDTSTGPSSFAPTPLDAASPVDEKPEEGLYSKNAASTKAPTTVITISNHTNAHIVLPHSTSHTTTTGTVSNLRRCVADMSTPTSSANGHPFAGLTLRNIKNSLIVCGQVAGATHVTSVENSVVVAATRQFRMHGSKNVDVYLHSASRPIVEECEGVRFAPLPASYITEANAQSTNQWDQIDDFDWLQAEQSPHWSILPLEKRVEERVWKDVVPGGHSISLEDILKAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7H5</accession>
    <name>A0A6A6R7H5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_614466</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="229" mass="26788" checksum="0FC75A2A1E1A3FC9" modified="2020-06-17" version="1">MSNGNFCRRCRRQFVNRHAIKQHLVTSSHHHLCDNCNYDAYDFNELLDHWRDEGCYEVCEQCESGVPPGTMAHHLQKHYACLICQEHCENQADLNQHANTHVYTNITCWGCPRIFKSLPAMILHLEGGNCDSDITVVDLNEAAAASPQWHYFISSRWRNILHGRRSLRRYRETPLPFKCPCCDMRFRYLSALIQHVANPTKANCEENLLSFPIKMLVLWLSLYQRHWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R880</accession>
    <name>A0A6A6R880_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_523370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2500592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="83" mass="9317" checksum="43116A54A4FD6065" modified="2020-06-17" version="1">MCASVQLANRELYVFLVRLTVAFEVVPARDIEDRPVLDALGCSENPSSLTTVPKPFKVGFKVRDRGALDKWILESEMRTAHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8U8</accession>
    <name>A0A6A6R8U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_238142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8U8"/>
    <dbReference type="OrthoDB" id="5329332at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="260" mass="29853" checksum="F00B14D2F35E1EB0" modified="2020-06-17" version="1">MVVIRTPKADILPAYTTCPLSVDILETVRKSFAIGAFAHFHPRVELLIHDRPNFHNKPHHEIRNILDAEGQTGPFLLLEERTEGQDAVWYITSPEAAKAEAEEGVESFKHHEGETPLLRMWIKVADVPLEHDNLEIGNSNILETLQSTGLEYPYDAHAEQLRAFTLGENFQTDHSFVPPAFIIAEDDEVEVSYDLKDRRHISLGRGPPDMVVRLKEEVAVREGLKVEWHPSSKEEDGTWELQMSYDLESERWRRHVPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9L0</accession>
    <name>A0A6A6R9L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_555598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="357" mass="40011" checksum="CA66C90A58B9D69D" modified="2020-06-17" version="1" fragment="single">RNSRFAGWRLGVLTGCILSTVVLCINVILFVVGATAEGGYVDGFATLHKGPGHRIGNLSTMYHVLINVLSTSLLSASNYTMQVLCSPTRKEVDRAHARGQYLNIGILSTRNLWSISKRRLALWWILALSSVPLHLFYNAAIFKVTSGNQYVAQFVNIAQTDVWNRLNSSTTIQRMNNTEWRKTYSSRYIAETGDIYLIVDQIALEYEYFKSPSHSLSDFSLSAPMSMSIDPEKDLSLTGKMQWQEGYWYIPNTIAYLNKTLESSGNYSWFPDTESTDNPNNTYHIQYSFVKPVIDPNTSKVQIGLIFMAIVIGCNFVKALVMLITFLDHRSAYLVTTGDALASFLARPDPTTVGCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAW3</accession>
    <name>A0A6A6RAW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_534167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAW3"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="260"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="632"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="866" mass="95447" checksum="247931345068726F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBR8</accession>
    <name>A0A6A6RBR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutathione synthetase ATP-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_522159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBR8"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="283" mass="31601" checksum="6240606618E30FAD" modified="2020-06-17" version="1">MPVQPFNINICDERPLEYALWAHDPPIPCYRADFPTEFLARTTRTEAGALLFYPPHSTQPVEISVAYMRAGYEADEHDEEGVEARVRIETSRAIKCPSVLGQLAGFKKVQQALAGAGVLERFLPAGSVERVRGTFAPMFPLDETEVGRWARKEAWRVETAGRYVLKPSLEGGGHNVYRGGIPEFLERTPEVEWRNWVLMEMMEPPKLRNVLLSAEGVHEGGVVSELGVFGTCIWRKRKGGGAEIVENRQAGWSFKTKADSVDEMSVVKGYGCFDTPCLVDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC33</accession>
    <name>A0A6A6RC33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_555772</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC33"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="392"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="488"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2501280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="569" mass="61998" checksum="51CF50B74D6A856B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCJ2</accession>
    <name>A0A6A6RCJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_200459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCJ2"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2501453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="695" mass="76631" checksum="3566608DE87C1DC5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD85</accession>
    <name>A0A6A6RD85_9PEZI</name>
    <protein>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="453" mass="49891" checksum="2BE3B76C6653B572" modified="2020-06-17" version="1">MDIKLSMGSVSCCCFRDAPTIYPSSFTNPQLSSSLQRTTFTPITLITLTEFTTVHQQTMEKPTVYSQGAIKNEPQRSTTTNCKQKPKQKKKPAKAAAAANQNATPAVKTAQDGDQTTLVNNTASRMSQKTKTESGPAKSGAKTTCVVTTTGPTASATSFEDCLEGPEVEVYHNTATGRELVGIIKLRLFKYLSGAAKTAFDSSPAPTGAGPDQYVISTTSNTAFGLKAILTWMKGCAAVGKVMPLSAFPREGSVPAVASEQRSISLLDLYRVLQTARNLDLQAHTRPLIKEIKAHIFDRAPDAYALSLIWKNRTEHLHLTNFTIRHVCRHWLTGSLGDWDAVESYLEKAPGLKSEVVLEGQQKEFHYGKKKKDERYEKVPETKASVSKVNKWTAKVDHRNVEVDTTSWDWTQGNILQDIKPSPPASVCGGVSYRLSLWESLDYHYWVDETHLG</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        </location>
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            <begin position="94"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="271" mass="29673" checksum="47B9089D65C65F7D" modified="2020-06-17" version="1">MAAAVQPFPRSCQSSSLHASINVKCWAGWHAHQRVSDVSQRRFRVPRNDPRCHQVRGGSSPRRPLEPGCWTGQVLALIPPQLALLRACPIEGEFPADEGDDEGHDDAALQGEPLHHPQRTATGGHGLAEHVSELRVALQLLAIAILAAVSRYQADPAESIPRDMHYPGAHPSPDDLVTYIQAGRRPKRRKDQIQLVARSPQPFPICVSPTPPWIAQAARIPKRASVSKAGCTACQQRQPPQQPAPMPPEQSQHLTSPSRIADTEMPPAHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="620"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="780" mass="90681" checksum="40879A5AA00388B4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REH9</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502826.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="207" mass="22727" checksum="21A0A37FD12A0637" modified="2020-06-17" version="1">MTSHVDTAVELLSNGRTSSIRPEPQFTPRSSFRKQRLGIRSTCRSVHSCCGQEVPTPPYIRHSAPRRRDSAFLLQVGAANQSIRLGVGRLPRSGRGVESRQPHVFAPGCFYSDRSPDRTGRVSDNPWCSEQLLVISSYAMSRQAGLGFSLPRLAASFYYSHLSPSPIHIKACFPAFLLSANVLALLSSGPELSYAIQPPSPFTPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFY1</accession>
    <name>A0A6A6RFY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8V2"/>
    <dbReference type="OrthoDB" id="2872121at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="15564" checksum="4ED10D8B580C24B5" modified="2020-06-17" version="1">MSGFLREEEQKFEGGGNNQGGNDNQGGYGGGNDNQGGYGGGNDNQGGNDNQSGGYGGGNDNQGGGYGGGNDNQGGNDNQGGYGGGNDQQQQQNSSGGNDQQQQKSSGGFMGQMKTTGEDGAINTEINQFATKEGVPAGADGFIDSAVDQEANKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8Z5</accession>
    <name>A0A6A6Q8Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_531846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8Z5"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2488785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="17986" checksum="DC4AE25BC2360002" modified="2020-06-17" version="1">MWCLVKYQAFLRKQTRFNPTRGGPFHFRAPSKMFWRTVRGMIPHKTARGAAAMERLKTFEGIPPPYDHKKRMVVPQALRVLRLKPGRKYCTVGRLGHEFGWKYQDVVARLEERRKVKGTAYYERKKAARRQLAEAQKTAKVDEKVASQLAGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q978</accession>
    <name>A0A6A6Q978_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell cycle control protein cwf14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_473637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q978"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2488564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="149" mass="17294" checksum="1072D89D36A67D58" modified="2020-06-17" version="1">MPPTRTHARSRKPPPEGFSDIEDTLLEFSNKMKDAENASHEGKKKYETLWPIFQITHQRSRYIYDLYYEKEAISKTLYDWLIKNGYADAMLIAKWKKMGYEKLCCVRCIQTKETNFSSTCICRVPREQLKDGQDIQCVSCGCRGCSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9N3</accession>
    <name>A0A6A6Q9N3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_472268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9N3"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="453" mass="50078" checksum="C6BFFF2E5AD566E2" modified="2020-06-17" version="1">MKEREKKRKRKLKEEEKAKNNIPTLTSTEEATSDDKVSKKSSKKQKRDKSTKPSTTKDDTSIIAAPPIPPPTALPPAVKLTPLQQSMRAKLASARFRHLNQTLYTTPSTSSLTLFSDNPEMFTEYHTGFAQQVAGWPENPVDGYVASILSRGKLIEKRDPWAQKNKGQKGQKPKPQPTDTPTTEKALKLLPRNLRGISTIADLGCGTASLSLALQPHLKPLKLAIHSFDLSKPAGAAHGLVTVADVAALPLKDGTVDVAVFCLALMGTNWLDFLDEAYRILRWRGELWVAEIKSRFGRVNRAGKVLAHSVGSQKKAVPFAKKPKPPTKAQNRQLAEAETQVDDQLLSVEVDGVELDAQKQETDVSAFVEVLRKRGFVLDGEEKEAVELGNRMFVKMRFVKGTPPVRGKNVVKEEEVAAMGGKKKMRYLEDLDKEEEDGGDEGAVLKPCVYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9W2</accession>
    <name>A0A6A6Q9W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_544540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2489125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6133115at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="517" mass="57083" checksum="8B2954BF0BDCEF4E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAL0</accession>
    <name>A0A6A6QAL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_519528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAL0"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="276"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="446" mass="50149" checksum="5D63EB7996DBA62B" modified="2020-06-17" version="1">MDIIRVIFSFTPVSYGFALLSLLIPVILLRVFQSQKGYATQLSPESCRRIGLRGRSNLADHQDSRYSSGSDPGISPDGSPLWKVKALFIYPIKSCRGIEMDHGEIIRTGMKYDRQFCFAQQVTSLPSSEENKDGSHTVKSEWNFITQRTFARMAKVETEVWIPDPSLPSYSPHAEFVKSEGCIVMRFPFSPDVDLSWGGVKALASMFAAKFCGQPEPSVELRIPFNPSSDRINEKGYTSEKMKIWKDAPEALNMGVEVPEDVMAKLKYSLGVTNPLTLFRIDTQKYREVFKCAPKKQDVGYQTIIGMADSYPLHIMNLASVHDIASKIPEGYYKEFNPLRYRANVYITGPPAFSEDSWAKARIGDCNYHISCRTTRCKLPNVDPKTAVRDRVEPERTMRSYRVIDKGSNSACLGMQVTPLVEGTGAISVGDEVKLLEQGEHFFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAL3</accession>
    <name>A0A6A6QAL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_472303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAL3"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="10">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="35071" checksum="DCA99AE4A753532D" modified="2020-06-17" version="1">MPYSHHSHSGQFCAHAKNTLEEVVQTAIARGFQSYALTEHMHREKEDFYPEEESDYTEEGLVQLTDAFYAEAVRLRETYTGQIALPVAFETEWIRPSTLGLIRSLVAKHPYDFLIGSVHHVHTVPIDFDKATYQKAREIAGGTDERLFEDYFDSQYEMLQALQPAIVGHFDLIRLMSDEPNAGLRRFEGVWTKALRNLEYIISYDGVLELNSAALRKGLDEPYPCLEVCEKFLRMGGRFSMSDDSHGVEQIGTNYRRLLHFIQKASIPDIHIADCGPQSGPDRRSPTPKFSSVSISQLEKHAFWAANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAS0</accession>
    <name>A0A6A6QAS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_544743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAS0"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025500642" evidence="1">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="483" mass="53169" checksum="8621DDC3215BD0C9" modified="2020-06-17" version="1">MFFLWAVLCVFGFANALPLQVTPRGIDLPVCIVGAGPAGLAAAKRLESKGQKAVIFEKQVEVGGKCQTYYDKGGFHPLGALLFSNATYTETVKIVDAANVPIYPFSAQGGGQNWEYNWTTGATMQDAPLSVQFQAALSGEIGKYIQLWNQVFAPISGIGYKKGVPHNLTVSTADWLSTNGFQYLPALIIPAMTPYGYGDFRQVPILYMLQYFTPDIVLFFAGQHTGYLVDFHNVFKNFAASLSTTEIHLNTTIEWIDRSGSTPVLRYHDPHPETYHNHTEPCQHPSHTKIQVCSALIMAFPPTLEALEGAHLDISTAEQAAFGPVGVNTYYSGAVRTRTPYGLAFNIEQPTPFTPPDADGEPVTVIKLSPYSDVATTWSWGAYRVPQTIQQAKELLKCTLSKFNKDPRNATDVAVPVTDADVVGFRKWDYFPHYDTEQLVVGAYDKFNALQGKQKTYYASGLNGFETIEFAVRAGYDVADSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAT4</accession>
    <name>A0A6A6QAT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor rrn11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_472359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAT4"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49624" checksum="7ECEC97317F17FDE" modified="2020-06-17" version="1">MQYFVPPFDSSRQTTHSLRASRYQKLHTSGRKRKRHEDDEDPPESPDDSTDAGATSNTQSPSARASVASLSAAETAQLRVAGLLPHEGFQAPKKPFPHAPLPSKLPGSRTTAAHVQRELAALKPPLYAVAAAKATQRVDGVGQQDTLRQTHIGNLTTMLHRCLLEGDYERAGRAWGMLLRSHARGRPIDVRHNGRWAIGAEIHLQRNRISRQSQPDEHVEDSDSIQSQTDRHPASTEEDIFSEEGFRQARHYYDLLILQYPARKMHAHAVNQGHFYPAMFSLWIYEVSQQSKIAKERLKSAPHSSKSHSRGSDDSDMDESDHKSDVIMVVEMKRAREIAERLDQLLGAPPFDKRPDLLRLREMVARWVGDLIYQDDPGPGPMDEDGMEYNSFSDHSDAYETFIDSVSRFEEGPLPADRHSEEDGTQDSHRATEYSALVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAY1</accession>
    <name>A0A6A6QAY1_9PEZI</name>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="274" mass="31786" checksum="71393237EA3329D0" modified="2020-06-17" version="1">MTGMFPEKYSTDLEKGPTDLEDLRTERSWLDHGEAILAVLIYIPVLLYDETLRSMRGSERLFLYEALEYSSDNDVDAVFGTNLLILFLHLFPWIFICFLAHIKAYRTICEYVVILPTLWMVLYLSRFVCAGAYGGVDNNSYKEWFLPVSIFCGIGFLVSHMWILLYTFRYKTFNRNEHSEGIGIWFSKVSFNACAPTMTLFGFVLCLGRTPNLIFWLRNFLVLLDVMLFASAIPESSLGTPAYELKETLFEELQESCGMKEKSGKIRLEKYEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBE5</accession>
    <name>A0A6A6QBE5_9PEZI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBE5"/>
    <dbReference type="OrthoDB" id="3772738at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2489384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="108" mass="11926" checksum="7D5E8BACE2698F4C" modified="2020-06-17" version="1">MQSRLSDVVGDRYSEIADIPRTRSLDLKRSQPWSNGSFSCVAHSSPVNAQHNSVAFFPPGWELAKKKYSYIWQCCACGWTGINITAATCPSCGTARCAYCQTTKVQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBL9</accession>
    <name>A0A6A6QBL9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_184434</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="430" mass="48277" checksum="B2F044E98097B637" modified="2020-06-17" version="1">MKATITQLKKDIADAKTRHDEASKDIKRIERDMSEFTNNKDSKLAELQSTLDKLKKTLSKNSASIKPLQAEMREAMVDSEQCGGDLAAAQEQLQDTQTTLATQQEEIDALVAEQARVKDAHDLASAHLSDEQAKLTGFDDELRALEEATRSKSALITEEGLEQQKLGHQIEKFHKEQESAAHTLKALEKEHDWIADECDNFGRSGSPYDFKGQNMGECKSTLKNLKERFQGMKNKINPKVMNMIDSVEKKEVSLKNMMRTVIKDKRKIEETIVSLDEYKKEALQKTWEKVNGDFGNIFNELLPGSFAKLDPPEGKSISDGLEVKVSLGKVWKQSLTELSGGQRSLIALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRTRFSEGTSIVQALTPADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCD2</accession>
    <name>A0A6A6QCD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_567016</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCD2"/>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
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    <feature type="non-terminal residue" evidence="3">
        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="146" mass="15979" checksum="E8E1B130CC3FF93D" modified="2020-06-17" version="1" fragment="single">IPQEPHSLPGSIRLKLDPPFLCTDAQLTACLRKVSLHTAVIALGGLDAPLAESALSHGQRQLLSLTRAILKKEAQGARVLVLDEATSSLDQVTERTVQRVLREEFKGCIVVAVAHYIETIVDFNEVVVLVLKIGRMVARGRPRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG18</accession>
    <name>A0A6A6QG18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BU16DRAFT_493630</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasmic vesicle</location>
            <location evidence="1 16">COPII-coated vesicle membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
            <orientation evidence="2 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG18"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="127"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="405"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="523"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="639"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2490946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="772" mass="86157" checksum="2617CAD4461C06D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG87</accession>
    <name>A0A6A6QG87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_142017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG87"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="558"/>
            <end position="578"/>
        </location>
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        <location>
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            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
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    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="320"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
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        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="757" mass="85561" checksum="D7F293B318A0BD17" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGC9</accession>
    <name>A0A6A6QGC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_621709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Motile_Sperm"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="2"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="295" mass="31504" checksum="A2224D7A4D01ADEC" modified="2020-06-17" version="1">MSVELDPVELGFKRPFTQEVSQTLRLKNPNTDPVAFKVKTTAPKQYCVRPNSGRIEPGKDVEVQVLLQAMKEDPAPDAKCRDKFLVQSVAVTADKEFHNIASIWSHIEQTSKSSIQEKKIRVIFLPADGSTATPARVNGVKHEDESTLLSPSPEAVTPMRSSATPVGSVSRPEDRPADNKHLGDAVASAHNPATSGERSTVGAAVAAVTNAVPTSTAELQAQLTDAKAQILKLKQQVEQHGLRQRKGEAVAQDSSNRVASGTTGMGVQHAPAGGVPVQIAAALCLISFLLAYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH95</accession>
    <name>A0A6A6QH95_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_594366</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3797007at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="936" mass="102727" checksum="7719AACD59960CA6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHK0</accession>
    <name>A0A6A6QHK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491559.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <name evidence="7" type="ORF">BU16DRAFT_584765</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 269.34</strain>
        </source>
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        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1814" mass="200730" checksum="EBA6A46E79177BF6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
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        <source>
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    <sequence length="360" mass="41856" checksum="7AC531FFBC2955B1" modified="2020-06-17" version="1">MSELSISRNGSYPTDWGLAILYFPASIGMIRAYIYNQLARTFYIVSFIWILRANNFHWTTFLWVFQASLFMAVFISEMLWLLLAVALLFSSKSTLTTPNSVYLIHTRTIARYPVNRISSLKGRLEMLLVFFLCLVLIGIRVFHGFPLAFSISFTSFAFCELLRSSIFAVRKFIQRIFAKPATTAQAPTPTTVTNDDALAATKGNQGTFPLQSFKDIGDTFALFCLALSIVQSFIWLYKLDRDYLQPFYTSPDKHYPVLDVVERAYDLPVFHFFDHLGAIIFFAIIAFLAYRHVEGNPWQPYLQAQERPRELDERGLVDPLRQQYEDFKLSRSLAAQKRRNVYRYPKTDFRDEPWYEYHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QHS9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Ezra D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="33639" checksum="3D86C86FEC2E4C5D" modified="2020-06-17" version="1">MRSSIIFSAAFAVGALAGPFKREDGGYVVTEVDVVEKTVTVVVTATGPPPAVTEAAVTFSPVGHHYSHSHFHHYSKPASSSAAAVESSSAPAYTPPASSAPAYTPPASSAPAYTPPASSSAPAYTPKPSSTPAPVSSAVYSVPAPSSSASYGGGVGPAHVTGDAEADLTEGEDYQNMVVFHHNINRAKHGAGVLTWDDDLAASALKCAQCSNTPFQHCNAGQNMAGSSPIANVSAGITEGWVNGEAPAFADFYGQANPTQNFEAWGHFSQVVWKKATKVGCGTVDCRNTVGNGMWQTVCNYDTGNVGGEYGDNVGKPISDVLAHWTD</sequence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF141">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025692261" evidence="1">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="247" mass="25263" checksum="36B3E799EDC38CAD" modified="2020-06-17" version="1">MYFYVLFLLASLLSVSRAQTPSGFTPSVSNQLTVMFNSTVVSPAGKQLSKATTQSQPTIGVSGESSGKTFMFVMLDLDVPSRTGPRQTLLHAMEAGFKASTKRAASSTSILTSSGKALAPYIGPSPPVETPAFGHRYVQLLFAEPDNFAVPASQTAAVSKRIGFDINAFMKDAGLVEPVAANFFVVEGKQEAGASGTAAASVGPTATGSGGISKSTLQPFEGGAGSMRVGMKGCLAVLLGGAAVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJZ8</accession>
    <name>A0A6A6QJZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_583719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJZ8"/>
    <dbReference type="OrthoDB" id="3909804at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025581614" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="29481" checksum="BEDDDDB15678770B" modified="2020-06-17" version="1">MITRFALPMAGAVLLLATLVPVEAIKVPTSCYVPNGDPRTNHRPCYTDTADGHSHCCDPINEVCLDNGLCFAQGQTNPGYLYRDSCTDKSWGASSCPGPCRKTYTNSACPIVGILNPSQDSQFCCLSFNATANECYGEDATFNVGKVIANWGPLEQVASASTASGTQSTASPTSATSAPAAATVTVKSTSGGHDAAIGAGVGIPLGILLVASLAGLLFQHRKHKKQLAQWQYGGQGGNVAGVAHQGGGVYPLQDPKAAYQHTPQPAPPQQAYEMPNVERTELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKB5</accession>
    <name>A0A6A6QKB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-dependent flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKB5"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
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    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="454" mass="49455" checksum="B3CFA4D8CAB5A427" modified="2020-06-17" version="1">MAPSNLNAPAPNIPYFTPQHRHSPGTPKELSSKTPTLFTPLQIRDVTLRNRIIVGPMCQYSAAASGPEIGALTDWHVATLGHYAIKGAALVFVEATAVQPNGRISPNCPGLWDDAQIAGLKRVADFVKSQGALVGIQLAHAGRKSSTAAPWLAEVAGRKSKRADKDIGGWPDDVKGPSGGESQVWDGVYDSETNRFWPPKAFTTQEVKDLVRDFAKAAERSLKAGVDVIEIHAAHGYLIHQFLSPVSNRRTDEYGGSFENRTRLLFEVIKAIRDVIPASMPLFLRMSSTEYLDDTDIGKELGSWVVESTIKVAKQLPALGVDLLDVSSGGNHPAQRIDGTNTKDYQVKIADRIRNAVHSDNLKLLIGAVGLITDAEQARDIVEQAGTVAPLDSSIGEEAEAAKDTTDAKDGKQPMADVILVARQFLREPEWVLKVAWKLGVDVWWPSQFMRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKN4</accession>
    <name>A0A6A6QKN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKN4"/>
    <dbReference type="OrthoDB" id="3801542at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52354" checksum="70D0468FFA19A53C" modified="2020-06-17" version="1">MSKSGFESEMPSVQGKPTKLEQPLHRPSGATSKIGPREFNAFEPSRYIYSNDVLIASSGLTDVSKNRSETPENVEVGYPDERSNISYRACSVDFRIMKAQWLFDDRSGVIQSTNGSHTSTSTSSAAQFTSENKKRKRQNRHGGRSGENDEDDIADNNDDNGNNRRNLDSGKRPRGSKKRFACPFFKRDPEKHMGRRSCTGPGYSGIHQLKEHLYRNHEVRPCPICYADMKTDEALELHVRSQVCERREAPPCEGINRPIKSRLENRKGWSKKSDIEKWEPIYRILFPNDEALAMPSPFYEDDELPLPGLLSAFEEYCRRELPRSVRMELDSKSRRGDDINSEIETLVRHCYDGIVTTFKGSGRSKTAQAVSTLAEPETCVLSQSDESTSVGSSTHDALENILGQVSYVTPDLTFDGFNTSGLEPSTQSFDYGTKTSQEGSDQPDYFGETFDFMRILDFPFDPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKQ5</accession>
    <name>A0A6A6QKQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_583934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKQ5"/>
    <dbReference type="OrthoDB" id="447346at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF14">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="147" mass="16315" checksum="92021EA6DD2AEDCA" modified="2020-06-17" version="1">MSSEHQAASMPREGALCWVEFLAHDVPKLKEFYSALFPNWDFKPSTKEYKAEDIAMVSFAGGSGLSGGILKLPADCNREEQPNGVGTTSYFLVESIEEIKPRVEKLGGTMCLPKTEQGKSGWFANFRDPDGNRFGVYEVNRANLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLX8</accession>
    <name>A0A6A6QLX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_81567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLX8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="79"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="577" mass="61894" checksum="468B314AFDBA641A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLZ7</accession>
    <name>A0A6A6QLZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_73232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLZ7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="156" mass="17032" checksum="5065241D89AC2387" modified="2020-06-17" version="1">MPCLGDKPQMAACAIAVMSEHRHETTSKPLHRTPQPAVRICPTNSTPRFADDSWTVPRMKTGENFGPFTAPFVPVVSGVTLQLGLSHESSPVGQRMQPRRVNGSCQQIRRRSGHKSLPSFLQTFLSFSTTTPTPHQLFAAPPQPTPATVFTQAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM41</accession>
    <name>A0A6A6QM41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_79795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM41"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="39620" checksum="8B2E8E4103649088" modified="2020-06-17" version="1">MAYYPSSALIPIYAMFLSIGIIFTTLRIYIRFYHKISPFQTRNSFSLDDFFILIGLIVVSTCTAIQFYNITHGTAGGAVSNATKNEAIVIEWKVEYAMMAIEKVAFGAIKLSLLFYYKRMFWSYQSFNRINNILISLVALWSVAFLLADLLLCGKHFELNFALDQTVSQQKCGDKGMVLVMFAATSVLTDIFVVGLPLPYIRKLKLERRKKRAVYFVFLLGGISTIAGLLRFIFLCVAYQLGRLKRDYRAPPEAKTPHVLQAIQPTFWVMMEMLIGLWAANLPALAPLLRIAQKGYQNSSWYGKLPSFSRFSGTTDSEEKKVKVYEVLNKDRSLVSWKSRAGSDDTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMF6</accession>
    <name>A0A6A6QMF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_528750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMF6"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="100"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="697"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="555"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="756"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="925" mass="103885" checksum="8AF248BE6D243E93" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMR3</accession>
    <name>A0A6A6QMR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BU16DRAFT_467544</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMR3"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
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        <property type="term" value="P:Golgi vesicle transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bet3"/>
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        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
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        <property type="entry name" value="TRAPP_component"/>
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        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="208" mass="23455" checksum="38AAF06CA1A72F0A" modified="2020-06-17" version="1">MASTKAARLGEETRIDKVSAELVTLTYGTIVAQLCKDFESDYLEVNRQLDKMGYNIGLRLIEDFLAKSNAPTCSNFREVAEMISKVGFKIFLNITPTITNWTSDNKQFSLLFEENPLADFVELPDDGRAQDELWYSNILCGVLRGALEMVYDTSASLTNSVTLSEIGLQVQMQVEAHFISDVLRGNDTTEMRISLIRYIDDEMPPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP75</accession>
    <name>A0A6A6QP75_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF7357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_56029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5368821at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
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        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="871" mass="97255" checksum="C7BD1E2C943464E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQJ3</accession>
    <name>A0A6A6QQJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative vanillate O-demethylase oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_550593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5390at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:molybdenum ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="4">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
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            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="549" mass="60691" checksum="36D05B34D8794636" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRQ0</accession>
    <name>A0A6A6QRQ0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_461127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRQ0"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42983" checksum="AFE28694A80F785F" modified="2020-06-17" version="1">MAGTNLRSQTKETAAGMKRKADTNSSPQAKQGKEDTQKKQKTIEQTMLGQEQSGDEQDKDVPKNENESDQKSEDEKEESSTEGGDDTMETETNGKAIETSPERAKAMPSNILEKGIIYFFTRKRVGIDDAESAADLQRTYFVMRPIPVGAKLGEGSIDESNTNRLFALPKKVFPKTPNDKFMAFVEKANTTMKDLKEKFFQGSTYETQTAGTRHNHPINTVGEGVYAITRVENSTHLVYMLTIPSEPGEVQEELGLRSQGSFAISIKNPTRKGPANASLPQGPEFPKEIIEEFRGLAWAEVKPNYLDYPNAQILLIGEGNNNDLGTAVEPTSKDQKNDDKETPLEEMEKLEHEDELRVQHLHGDDSVFDDLKMSKSEYPKVPTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSI6</accession>
    <name>A0A6A6QSI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_561382</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSI6"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="472"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2495072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="552" mass="59713" checksum="C9A6032E079F40B0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTI6</accession>
    <name>A0A6A6QTI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_561704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTI6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="151" mass="16452" checksum="62A2C43B217D4513" modified="2020-06-17" version="1">MPERTPSATIATSDVLADPPMETTKIVKSVDAVTDSSQSSHTATRENPPGVTETSHASHVLHLETQESPGPTRFTNGVSQMGTDMSLQHIVGTKSSAKARLSYSMSRWLAESPEEEYWHTCSRTDVSERRIEDSCEEEAAITFTLSGKPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUS3</accession>
    <name>A0A6A6QUS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_485811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUS3"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2496258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="420" mass="46725" checksum="D71BD4255ACC012C" modified="2020-06-17" version="1">MLQQRSSLLASSLASTFRRSLLVQTSSSAQRCRRAYSIHADASVGKNILDIDPSKLSIEKTTTPKTLLPPEELVFGRNFTDHMLSLEWTASEGWLPARITPYQNLSLDPATCVFHYAFEAFEGMKAYKDKNGKIRLFRPDKNMERFNKSAARIALPNFDGDALIDLIGKFVKLDERFIPEARGYSLYLRPTIIGTQRTLGVGPPASALLYVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCIVPQMQAASRGFHQNLWLFGEEEYVTEVGTMNLFAAIKNKETGQKELLTAPLDGTILEGVTRDSVLGLARERLEPQGWKVDERKFTMQEVSDASDEGRLLEIFGSGTAAVVSPVRKISWKGRLVECGLEDNQEAGPIAQQMKDWMEEIQYGDKGSEDHHWSHKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV80</accession>
    <name>A0A6A6QV80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV80"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="704" mass="77468" checksum="AD9BDDA032DD5D78" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVQ4</accession>
    <name>A0A6A6QVQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_572418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="4">
        <location>
            <begin position="45"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="370" mass="41412" checksum="653A7DD7B0C29FC3" modified="2020-06-17" version="1">MPLTDEDAALLAISTFCESPLSQDQEAAKASIHSILHGEGADPFVDIHELFGLYNVLYFRSLLLPQVEVLWSPRLTLCAGICELTKDNEGKYRRIRLKLSEPLLKFRPREDTVDTLLHEAIHAYFFITTSWQHSRGDDGTGHGVGFQLLADSINNHASYAITVYHTFHDEVDSYRTHVWQCDGPCRQTPPYFGLVKRSMNRAPGKSDTWWDKHQTDCGGSYVKIAEPELTKQQLKNLSSKARAGRQKNKIDSWVAPKAENVSSPEKARVTTSPPISPSPGTVEGRTLTLGAHGGLKRRMDPISETNSATQSVSREYPLPGNLPRSVKRQKRELDERLTSITINSQVECPICGITVVEENINEHLDELHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX49</accession>
    <name>A0A6A6QX49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_342135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX49"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="315"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="450" mass="51281" checksum="631A1B5FF1C39679" modified="2020-06-17" version="1">MNSKVDGVDGVVLAVTSGHGNGKLPENVAAKPQERTPRPKRPNYAQIHSRPLPLEIYPVPSFIPHNPLSIARIVLTAVSQYFWPPSSHLPNLYKGYFSPDTQAVHITDPKTIRALWEQGFYGKGTLSRSEPRWLDQEKRRRGLIALETSEEVTRQRRETRRQFKLERARKERETIEQQLKDEGKMPGGAYIPDIREESALIQTVEASIATDILLDAGVALPSPTSLPGTHIATTATQDDSIVPENVDEDIDEEVEDQEHLQLTCEEAFFLVYALGALEVSEKDSPMSSSKLLKLFAEHSTFPSGESQYLQPDGAFLLRYVVYHHFRSLGWVVRPGVKFAVDYLLYNRGPVFSHAEFAVIIIPSYSHSYWTENPDQKAASQQGVERDWWWLHRVNRVQTQVHKSLVLVYVDIPPPTQTDVAIEQTDIGKILTQYKVREFVLRRWIPNRNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXI0</accession>
    <name>A0A6A6QXI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_549018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
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    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYP1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="12">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2497568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="626" mass="68276" checksum="0F637CC3960CA64A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ56</accession>
    <name>A0A6A6QZ56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_525175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ56"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2497529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="27712" checksum="7AB6164CFE9880B2" modified="2020-06-17" version="1">MSGLRILVPIKRVIDYAVKPRVNRAQTAVETANVKHSMNPFDELSIEEAVRLRERKVPVEEIVAFSAGPPKAQDVLRTAMAMGADRGIHVVVEESEQLEPLGVAKLLQQVVGQEKSNLVILGKQSIDDDANQTGQVLAGLLNWPQATQASKVTIEGDSVTVTREVDGGVETLRAKLPLIITTDLRLNEPRYASLPNIMKAKKKPLAKKTLKDYEGDFSARLKTLKVTEPPPRKGGVKVDDVDGMIGKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZA0</accession>
    <name>A0A6A6QZA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 7">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_571287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
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    </dbReference>
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        <location>
            <position position="134"/>
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        <ligand>
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        </ligand>
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            <position position="145"/>
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        <ligand>
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            <position position="221"/>
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        </location>
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    <sequence length="412" mass="43842" checksum="EFF863D7E674F8AF" modified="2020-06-17" version="1">MSAGWFTTFTNCRYVLNGELVSDHLVISDELGTILRREGYIGGECVDLEDTIIAPGFLELQTNGVNGFHFTQFEDEASYEKKLESTAKYYIQEGVTGWWATVPTVGEAVFKKILPSLSPREYPSAATLLGAHAEGPYLSPSKKGAHNESLFTLPSTPPSSIYGPSLSTSVKLVTLAPDLPESSSLIQSLTSSGIVVSLGHSPANYVDGLVALKAGATALTHTLNAMAPLQSRDPGLAGLLGLPPWVHSSQPPSPYFSLIPDGLHMHPSTLSLLHRSNPRKSILITDSIELAGLFDGTYPGHAQIPHEQTKHGARATIAGTDTLVGGCISLQEGVRNLMAWSGVDIAEAVATVTENVAAMMGIDGVGGRGVLKEGRRADLCVLSEEGVVLQTWIAGKKVWDKEEAEGDADQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZJ0</accession>
    <name>A0A6A6QZJ0_9PEZI</name>
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        <name evidence="4" type="ORF">BU16DRAFT_506535</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="782" mass="86649" checksum="43C836F4E8D313C9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZM9</accession>
    <name>A0A6A6QZM9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="74" mass="7990" checksum="A08E8160893C69B8" modified="2020-06-17" version="1">MEGANENAMIRPSGLRKPNPIKMPQSPSRGLSEISESQNNSRMLPPPAPVQLNGSLKHKLPAGMARERIISSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZT9</accession>
    <name>A0A6A6QZT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_458896</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZT9"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025522243" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="12">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2497240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="455" mass="50139" checksum="C2444AA1C4390DB0" modified="2020-06-17" version="1">MISLFVLLLSALSPSPITALVRPLDVGKLPALGWNSWNAFNCDINETKFLVAANKLVDLGLKDVGYNYVNIDDCWQVKDKRNETTGRMIPDPDKFPDGIKGTSDKIHALGLKIGIYSSAGTKTCAGYVASIGNELIDATTFADWGIDYLKYDNCNVPAEWADECDACVPDSWASHFRPIKNGTCTDKTGLCPDGYDFHKSNTAERFRIMGDALKKQNRTILYSLCEWGEANPQQWGNDTAASWRMSGDISPSWSRIVEILNENSFYLNYVDFWGHADPDMLEVGNGDLTPAETRSHFALWAAMKSPLLIGTALDKLSDANVAILKNKHLLAFNQDAVVGKPAMPYKWGTNPDWTFNATWPAEFWAGDSQAGVLVLLFNPAGETVEKFANFTEIPGVTAGEMYEVVDIWTDTKLGCFGGGVVAHVDSHDTAGFLLKKGCGYGYGYKRGKRSSRIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZW6</accession>
    <name>A0A6A6QZW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">von Willebrand and RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_331647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZW6"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01466">
        <property type="entry name" value="vWA_C3HC4_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000014">
        <property type="entry name" value="von Willebrand and RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="363"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="553"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2498001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118450" checksum="CB318BA7856D0820" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0D1</accession>
    <name>A0A6A6R0D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_322264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="41860" checksum="D89D767430BDAC46" modified="2020-06-17" version="1">MTDGNPTPLHVELPPTSTNGDGPSEPGRTTPKDSKGWDGKLRIERHPVITNPEALSDPEYSDEDAPPVEQINADEDLLDDVEEDEEDINLVHFRISSIPALRLERFKKIVRLCLRQNQISVIDLPDTVSSTLQEIDLYDNLISHIKGLDNLHALTSLDLSFNKIKHIKRVNHLTKLKDLYFVQNKIGAIEGLDGLENLRMLELGANRIRVIENLETLTALEELWLGKNKITEIKGVDTLTNLKILSIQSNRLTAISGISALTNLEELHISHNALASLSGVEKNTNLRVIDISNNPIKSLAGLSPLSHLEELWASYCQIHDFSEVEAELADKDELETVYFEGNPLQLRQPALYRNKVKLALPRIKQIDATFVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0W6</accession>
    <name>A0A6A6R0W6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_440192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0W6"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8641" checksum="6A38FFB0B758D391" modified="2020-06-17" version="1" fragment="single">AAQKRNFFTSTIGFMGLVPEEAQVGDRICVLFGVERPFVVRENGPSWTMVGECYVHGLMDGEAVDGLPEDRVREFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0X8</accession>
    <name>A0A6A6R0X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_525588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0X8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="98" mass="11149" checksum="A745EED916F0F332" modified="2020-06-17" version="1">MAELVGWLSRAVLFRRCLTGLNTLFQLCLSRFDRCKSLLMYILSAKAVSYCPYSGGNSKGPEPIISSECDTSKHSRLLTDDKRPRKHVWATVRAIWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R154</accession>
    <name>A0A6A6R154_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_524621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R154"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="15943" checksum="DEC24A4352D81293" modified="2020-06-17" version="1">MQGHLPPGIELIKVDDFQEWLVDLRVLDSNPLYENEVYRLKFTFGKNYPIEAPEVVFAKDATHPIPWHPHIYSNGIICLDLLDNAGWSPVHNVESIAVSLQSMLTGNSKKERPPGDENFVKYNTQRPKDINFLFHDNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R175</accession>
    <name>A0A6A6R175_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_525551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A6A6R1P1</accession>
    <name>A0A6A6R1P1_9PEZI</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="368"/>
        </location>
    </feature>
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            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="542"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
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            <end position="135"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498688.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="542" mass="59325" checksum="14C4699D4DDD63C4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R247</accession>
    <name>A0A6A6R247_9PEZI</name>
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            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
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        </recommendedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
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    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
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        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
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            <position position="431"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="580"/>
        </location>
        <ligand>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361193"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R253</accession>
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        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498472.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
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        <property type="entry name" value="GtaA_central"/>
    </dbReference>
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        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF5127"/>
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    </dbReference>
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        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="340"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="712" mass="76924" checksum="26BDEC251EE3892D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2F2</accession>
    <name>A0A6A6R2F2_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Ran GTPase activating protein 1</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">BU16DRAFT_524558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
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        <property type="match status" value="8"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="340"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
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            <end position="383"/>
        </location>
    </feature>
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        <location>
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            <end position="424"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="424" mass="45703" checksum="DE5A04A4249E9250" modified="2020-06-17" version="1">MASTKIFSLEGKGLKLDTAEDIEPHIKALRENDDVEEIKFLGNTLGIGASEALAKVLETKKKLQIVNFADIFTSRLLSEIPPALSSLLTALLALPDLHTINLSDNAFGLNTQAPLVAFLASHVPLRHLILNNNGLGPAAGVLIADALTALAKKKAAARASGEKVPDLETVICGRNRLENGSMAAWAKAYAAHAGVREIKMVQNGIRQEGIAHLLKEGLSQTTALRVLDLQDNTFTALGARALSDVVGRWPELVELGVGDCLLSGRGGIMLATALEKGGNQKLEVLRLQYNDINAQGVKGIAGAVEKLPVLRRVELNGNKFSEEEEAIDALREVLSARMEKAGVEDEDDENWGLDELDELDSEDEDEEGDEEGVASDQEEEGVEVEEKAAREVADTQKAEEEPVAQKKDEKVDELADMLGKTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2I0</accession>
    <name>A0A6A6R2I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_524981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
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    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="91"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="549"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="754" mass="83312" checksum="6F80A11EF8A17498" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Q2</accession>
    <name>A0A6A6R2Q2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_456008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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</entry>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="13200" checksum="E65180678E05F7A7" modified="2020-06-17" version="1">MAFQSSTPSKPLPELINDYYAQKPSFSSLTTTYPDENSKPQSTSIMPVHPAEENATGSITDQVAKDSSDSTASTHESHNVDTGVNPGGVHANAHKANPGPVIAENIGKPESKEALKKRAEELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6G1</accession>
    <name>A0A6A6R6G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha,alpha-trehalose phosphate synthase-like protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_523812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6G1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="907" mass="102460" checksum="B3A876E0BF3D2F08" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8G2</accession>
    <name>A0A6A6R8G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_556531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8G2"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="346" mass="36695" checksum="8791DC094CB584B7" modified="2020-06-17" version="1">MSTTIVTQNGSAKTMKAQIVVKHNGPIEEQDVDIPTPGPNDLLVKLSASSLCMSDMAAYMGHLGERAPVCLGHEPVGIVVEAGPGVVGFAKGDRVGFMPFKGMCEDCEECLSGQSRFCPRKVGGMTELHGGFSEYAIAAPLSTVKIPKELTDEEAAPLLCAGVTAYNALKVVAKEQPGGTPLNIIGVGGVGHLAVAYAKAFGYRVTAFDIAEDKLELAKAYGATKVVNSLNVKDEEIVQTQTTIVISGAAPAYALAVKTTKNHGRIIAVGVPHAPLTFNVLDLILREVSIVPICQGSKQDLDESLKMAAEYGIKPTIQIKKIGQLYEGFQSMMKGEVTGRLVYRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R994</accession>
    <name>A0A6A6R994_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_522108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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    </evidence>
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    <name>A0A6A6RBY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_211831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBY5"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18888" checksum="7AA966DE390DA852" modified="2020-06-17" version="1">MSAYQNTFSTADLRSGAIEYNRSKGQRVKWAHGQALGPGRRAEDNHARPARMPVYAKPKDMGPGDPRQKARVAVKNDISYASGDSSADEGSVDEASAAPVPDADITYSYDAPRGPSQGSQILGLALAKAIERFEVRETDKLIKEEYDVLDVAEAATPAPKVNKDGVEEEDYEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC06</accession>
    <name>A0A6A6RC06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC06"/>
    <dbReference type="OrthoDB" id="3799339at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="377" mass="44525" checksum="D8C81F0E74C1B471" modified="2020-06-17" version="1">MPRPRKYYDDDESDDDGYAPPPRKYRPENEPRQPDRRSRGDRNPYEDDDRIPPPPVTPNPPRQYPPVADPPEAVDDERPSGRHQPRARRAKSPPQDDGRPPRETRDPYGVDEGEIRKIPRSGKAAAAKGPSGADDDDRDPAPRRRRRGDDDLDRESKGMALPVRSKTRDNSPARDDRPRRRPQSYALPDPYDSRGAPRERRQPSRRYDDEDDREPPRRRDRERSGYKSDGPDPRRRRSRYDEDDYEDDRNPPPRRRDDGYRSDRARRDAPPPKPRYDDYYSDHRDDRGARRGGRDRYADERDRRDRYERDPRDRYDRDPRDDRYGARDTPRSKKEAADWQRQAKTMFMKHGLPVIKKEGGRLLQKEMAKFLAGQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC54</accession>
    <name>A0A6A6RC54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_532457</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC54"/>
    <dbReference type="OrthoDB" id="10453031at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="355" mass="39877" checksum="164BC471C05F64BA" modified="2020-06-17" version="1">MATHDTRYNQVLGAIGTAPTYPLLQPVPADSILHKNIQNFIDLTSPQYPPQPAHGATYIASQPVAHAEDVATVPRSLLQLPAKFMTQVFEDAVGLEGPLQRRALGYSYLVADPPADNFLPTRFRVEDVLNPDSITDYLALSLSCQTLYAEVGKAFWKRKFPAGDWTRVSDTLLPLARSKTDSNFLHLIPAIVITSGSKQNVRESCDIILVMQGLKTLTFAGLGEIDPTVPVPPTFVARNTTYIDQLLCQESMWFWDLLEQKGVKVKFDADYEAAYEKHEAGWRRLHLLGKVHTPCRTATQREADSTSLSQYFDTELVRRRQIFTDVVHRAQAAREASHAQQAQKPQQQRPRRHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC72</accession>
    <name>A0A6A6RC72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_196515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC72"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025561644" description="alpha-galactosidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="44"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="287" mass="30886" checksum="A6415DFCAB7D5E71" modified="2020-06-17" version="1">MRSSTTLVWALGATLAMARPTHKTTTATKATATVWQPAAGSQLQMILSKTIDTSKSLVPDVGIFDVDLFDTSSTIIAALKAKNKKVICYFSAGSYEPNRSDSSDFTSSDLGKVMDGWPDEKWLDIRTANVKSIMAKRIQLAADKGCDGIDPDNVDGFANDSGFSLKASDATTFVKYLATTAKSKNLAIGLKNALAIIPDVVDSIQFAVNEQCHEYDECDVYSDLTNQGKPVFNVEYPDSAPKVSTSDRTKFCAAYDGVTLSTTLKTLDLDGWVEFCDGTTATTSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC92</accession>
    <name>A0A6A6RC92_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_534036</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2501350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="33393" checksum="B62C231AE00C8FF1" modified="2020-06-17" version="1">MGETAGYGRPRSVDEYWKESCHSLVSTPSNPIRKSSSRGEGGGGRGGGEEGEDESRRKVRFETTRPASEPWRMQHGTNPHRRLVHFPALTPRQPIPGAQRTPDVVDRCPLLLSLWPQPSQEHPARAARRAIHGRREHRRELLCGRPAAAAAGGIEAARKPLLAASFSSTASCCCLGDVALHGAQIHRPHARVPSCRQPHPCCPRRGPATAEGASIVAVCGVTGPRARPSCSNQRGPASGQPEASACSYTRLQLSRSEPTIAVQSAPLATAKHQDVSPARCCTGCPFRPWCRPAPNPHPPRRPLTTAAALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCP2</accession>
    <name>A0A6A6RCP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10348998at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="652" mass="73288" checksum="F55B5462C3783819" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCS5</accession>
    <name>A0A6A6RCS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_521203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCS5"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="101"/>
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        </location>
    </feature>
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        <location>
            <begin position="120"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="191"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="340" mass="36778" checksum="2B00CEA247E9EF31" modified="2020-06-17" version="1">MPDINSLPPPSRSTTASPLQPRMAHTIPSSDGAPRPATPPTSHSPPRSLVAAAAMNAGMQNEDSRRPSGSPMRREVERARRRSSVRLVVQREDPTIPSPGELQQMSPSSRTRAQGFPPSPRRERAPSLGELHQELESEQEGQVNRLLNMIRQEHALSNQRNNHAPPHSSSAVIDDGPPQPARSPSLPRSGFASQQNVSHPQASPLIPRSRSPLPAYNSLSRQSSLHNQSQSSSHAGSPAIRPVSSALGSQNESSEFLIGTPASARDESAFYQAETQTLTRENQMLKLRIRELERQMTELNPTSPITHTPVVTSHLGRSPSFGPNSGAPGQVGDTKTEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCZ1</accession>
    <name>A0A6A6RCZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CmcJ-like methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_612011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33420" checksum="082DB8066696988D" modified="2020-06-17" version="1">MPGAVPETDPQTSIYFLKRNDLYHDEKPYSLRFTPPNDFPRSNIVLEKHDVTIRDIRPRLKDLSFEKNGFTIMSLESKMSYDDYDDEEKLINVYLREVADSLCAFLGAVHVQIFEHTVRKRHDEFPISTGKPYRYNQPTSMAHVDTTPEWARDMVQKLNRDNADEVLKDRVQCVNVWKPLKGPVKDWPLAMCDPRSIKPETDLEPCDLVYPDYVVENRQLYYSPRHEWVYLSGQQPSEAWVFLQSDTTADVKSVPHTAFPNPLADKDAAPRESIEVRALVYYGGFDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD39</accession>
    <name>A0A6A6RD39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
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    <sequence length="427" mass="44762" checksum="1B734A519F3DCE3C" modified="2020-06-17" version="1">MKFATVVLFATGAMAAAKVHRHRHRHAPNALLNREANPDVVTVVVYMLDGVKITEEECQEGIKNGTLIWGDDGAPVVASSPAYTPIPTPTPTPTPSSAAVKVAAYSHHYVAPSSVVVSSAAPAPSVYSGGGGDESGNVDVPFPTGLPCSKFPEGYGAVKNTYMGLGGWIGIQNPGGTAMGVSGQLGYTDIATIPKGSCEDGSCVKDGMFVSYNCPPGYAKSSWPKMQGATLQSVGGLLCKNGELELADGAIAKTLCVKGTSKVTVKVQNKMEKCSSICKTDYPGTEGETAGVYIPSGETQELFCPDKTEYYFWDGKGTSSQYYVNPAGYEPQDACWWGAPNKPLGNNAPMNIGVGYNPGDENAYISLFQNLPTNPVDFLDYTVEITGDNLSGKCKYSNGQYCDGDNCNTGAGCLVASRGGEVLIVLS</sequence>
</entry>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
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    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
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    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025683531" description="beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="10">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="170"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2502632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="741" mass="80731" checksum="C8FFE26D0FDD2513" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE36</accession>
    <name>A0A6A6RE36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_20156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="2"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE36"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="100"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine deaminase C-terminal" evidence="7">
        <location>
            <begin position="456"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="662" mass="71169" checksum="C748723C1366E7E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REU2</accession>
    <name>A0A6A6REU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_588439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REU2"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
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            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1220" mass="133856" checksum="FA03027EDBD7DA48" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
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    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="56"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="161" mass="17381" checksum="9C33A4EF2C56751E" modified="2020-06-17" version="1">MPPLSPYSPPPTSLSIAQILASARTHLTRLTPAAAAAELAQYHSHLQSQPPSQTPPPPPVLLIDIRPAAQRATEGYIAGATVIERNVLEWRLDPRSDARLEAAGGRYDARAIVICQEGYTSSLAARELQRLGLARATDVEGGYLNFRQCIKALQAVAYTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF21</accession>
    <name>A0A6A6RF21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_521917</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="71" mass="7742" checksum="F1DEE46B6B688265" modified="2020-06-17" version="1">MLEASLRGLLGQTVVLMGQWLRAAARGPMENIASAGLSPGTRKRQLLRRRKQAASRPSSTRAMRVIPIACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RGF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_498694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="595" mass="67137" checksum="593683B55562E07A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RHJ5</accession>
    <name>A0A6A6RHJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RHJ5"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF8">
        <property type="entry name" value="ACYLTRANSFERASE FABY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="191" mass="21304" checksum="0B19F16E87D2429F" modified="2020-06-17" version="1">MAPQVALRAAGEGDIPHINAIHAFYVLNTVITFTITPATDDEALSKFRAVVSQGLPYIVAVDNVTADIVGFAYASGFRTGKSGYRHTVEISLFCHPDHRAKGAGTLLLRKLIEVMKHPEDHADFVTVARDEDARVRNLIACMAVDEQSGKNGLGLKEYYEKFGFEQMGHLKRVGHKFDRWIDTIYLQLSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7H9</accession>
    <name>A0A6A6Q7H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_545542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7H9"/>
    <dbReference type="OrthoDB" id="3800432at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025380913" evidence="1">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="30859" checksum="852924DDCDF51C0C" modified="2020-06-17" version="1">MLSYHLRSLVVCSFIFLETVLAVIAPGYTTDLKFALNPITRTGPTKDQIQFILYTTVLEYEADTSTFSLEQIAGIAQQAWAELPIVHAQWANSCSGKQKKFITNNIPNMISAIAIGKEIYISSTAKRNEPNVLLENDDQTLTRALAACRAEYFPDASDEVNSNLHRTHGNCGEIMASALYLQRNNKFPWDADLTGTQLRIVAYGSKSNSIQPPCDGVNNDDVKRIGCHEWTDWKNMEVVGQDVVPEKVTVSPTAYHVVPLNAAWKIQTGDELDPINPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7S0</accession>
    <name>A0A6A6Q7S0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_587119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7S0"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="296"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2488355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="492" mass="54641" checksum="6ECFFE706FC554DE" modified="2020-06-17" version="1">MMDDGSFDDMLFKAISNEGSSQESLTASTDDFNDLLGTTGVSQTTLFHSEDDLFTNYYTDHISGMARKTETIADPSHRAISNSQEPSTKVEEMSPSVRDRNWVIKTIELVFESIVDALLEKNDKLSISLKTRSGSTGRRIDPTNGIVTVDGGLQTRSITFPGSTAHEAWRFTVLVRILELVHDALTSNAVITKRDIYYRSPDLFVKQAVVDRYVDDIACTFGISRNLLNVSAAAKGLMVGNFSIRRLEGTAIDGLTNREVRPRQSYIKHPLTRSQGTLVPNLNEDDILEVSTVRWIVVVEKEATFRSLVHSNLWVDISSQGILLTAKGYPDLETRAFLRELTTVAPHIPLYAMMDFDPDGLAILSTYKHGSYSLAHENSHAASFAASRPLNLPQIRWIGVKSCHLTSNSVLATKASEKAVGQAGGLLKLTTRDRHKARKMLEWDVLAEDGPEPEWRAEIQRMLLLNVKAEMQILEEHPGGSGKWLKGELGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q869</accession>
    <name>A0A6A6Q869_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q869"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488580.1"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="853" mass="94342" checksum="82F5600A863C0A3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB06</accession>
    <name>A0A6A6QB06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB06"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="475" mass="52994" checksum="B19226B759950F76" modified="2020-06-17" version="1">MDPQTPVGEESAGTAIASSDQSNIPSPVPSSPDGPDGSYALGSGAYETLSLPLSLKRVKEIDTHEVYTTAEHEENIKVILNLAKAYVHTDRAILLRAWRADREALDNLRQEKRRNAEYDSWDARATRRRGRNNSGHDGPRRDGPEADLPGGESAPSSPDEGAGAETIRADSADDDAEGLQDADMEDLMDVDQDNSLPGGDTERTNRRSSRGKKRKERSGSSDILTPVSFYKRRHEKPRSKPDGVELTKMLVRIFDLAVEERELGLDSIRLETYKHVTEGSRWNDKISKDVQKQGLSARDLIKNEHNRRTVQRSSQESDPESDPESECHVVPCEKVVLDKQPAVQVGGLVRCLRGHPLDTGVHSSADMAKWILDGTVMQQEPGYNLQQRCVDLVKYAPHFLSQTVATGAVLALCVEYDDLVGGLDVFKKHGPQLTMIDTWREQKQAEFFGKAGYDLTESNMKIWQELGDRLRKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBI6</accession>
    <name>A0A6A6QBI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_519350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="698" mass="75633" checksum="024B01821ECA9BE4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBM4</accession>
    <name>A0A6A6QBM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_162560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBM4"/>
    <dbReference type="OrthoDB" id="5279806at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="45439" checksum="7BC1F33AFC93D3D2" modified="2020-06-17" version="1">MASLAAIPDLLLHIILQSDLDTLLHLRLTSRSVKDLITAYESTVVRRVARNTFPQSKRLLLEASSKGKYDLKWLLDCKLRQLAAIAVDKHRWEHKLRVADGAAAEDPVGEELRERVFKGFRILRLFSNVARDAESVPLDELPQIAIAAQNDHSKPFHVVQRAVPHFRRKSLITSTAYCISKRWSQAQESTRLALLSSDMIREWRKELWILETRENFLRQMWPEYACYFQDMFFFVKASFSHLDKQDKHFDWGFEKGSKRLDDSWVSWYILREGPRLFWEQWWANRDNPEVPPILEEIEDAWDGRPPVLAKMERESCRRLFETLDDLAQDAYPYNPIATVFRPQPWTFFAEYGLAFERRLRAVERHPEEILERVAFHVDMKPFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCF3</accession>
    <name>A0A6A6QCF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_597283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCF3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF100">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="622" mass="69899" checksum="BD606BF9BC173C5F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCK5</accession>
    <name>A0A6A6QCK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_531457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCK5"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="51220" checksum="BC94759020DBF6D7" modified="2020-06-17" version="1">MTTSKEPQKVLEGVFAIHKPPAISSAEVIRRLQAHFNPSALFRPWFVAERAKMRAANAKPRQFNHLQVKIGHGGTLDPLATGVLVIGIGRGTKLLSRFLECTKSYECVVLFGAATDTYDVTGKVVSKGDYGHITREKVEEALKGFRGKIMQKPSVFSALKVNGKKMYELARAGAELPEIKPREVEVLNLEMVEWMEGGIHEYEWPAEEVDDVAQAGAQKLMGANAEDLKLGFKRLRDDDDGDEDVQEVQPDSKKSKIEQMDPEPVMSGALPVESTSRPSEAPLETAANPISSTESKPILEPAPAEPTESGSQDHSPKPKPNPPAARLTMTVTSGFYVRSLCHDLGLALSSYGTMSTLVRSRQGDYTLGQNVFESGELVKGEEVWAPQIRGMLEESMGKEGWEATEVVVGENDAGGWTPSSGDHPEGRGIQKHFNGRGKNNWRGKGERRGNYGRGRGEGNKRRNSSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCQ0</accession>
    <name>A0A6A6QCQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_586331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCQ0"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="296" mass="31808" checksum="869F17B46CB60A66" modified="2020-06-17" version="1">MHHDIVVRIFAASRIAKQCIFSPPVCYSWNIPDSSLNLDFGDIYLQVSSDDSYSWIGLGTGDSMAESNMFIIYTDGKGNLTLSPRTSIGYFEPSFNSSIQATLLEGSGVLSNSWTANIKCGNCRISQTSWIFAALQGDSIDETDRSTNLKQHNPDGHASTTFNLLEAVGGENSNPFLNQSSSQSSTASSTATSAPSSTTSSTPASTSSSLSQTSEICVGLFFSWRKKQKARNSATGQTGKEWGKSELDGRAVPRVELLGERDAIEVPATPIAPVELLADTHYETKKHSKSAAVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QED6</accession>
    <name>A0A6A6QED6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_575299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QED6"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2490632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="565" mass="63231" checksum="96D2EA3AD93D5370" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEI3</accession>
    <name>A0A6A6QEI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zygote-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_518757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10063670at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475">
        <property type="entry name" value="ZYGOTE-SPECIFIC CLASS V COPY B GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
        <property type="entry name" value="ZYGOTE-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025448393" description="Zygote-specific protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="7771" checksum="1CEF2F0D74C2BA95" modified="2020-06-17" version="1">MKLRLSILALLTGAAVPISAGPIGYGICQAGCAGVVMACYSAGGATWGATLGATAPATIIGCNTAFGSCQAACAAVLLAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG73</accession>
    <name>A0A6A6QG73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_564979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG73"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17320" checksum="CA9A7FACBA1FB36C" modified="2020-06-17" version="1">MGYNTENTEWPTATPVPEVQKTIIDTLFNLLDDKSAGVGDKLADEIFTSDGILHGGAGTAKGTDAIRHARDNAWKIIHTRRHKVLRVYVHDAEAKDLLIVGHVTMGFPNGKENAGEFTARILFVAPETEGGKPKIKDYNVWADTAPLSKAIQEALADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGH3</accession>
    <name>A0A6A6QGH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_543466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGH3"/>
    <dbReference type="OrthoDB" id="3687364at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="448"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2491229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="56178" checksum="2800F81AB80B0C8D" modified="2020-06-17" version="1">MNPRAESSPALELLTQQTRIPGRAFIVTRTLTSRALSVRNRELPGEDDRGMFLHYLGSAGLLIEKYADIRVEFTMERVVSTGPGEPSIRMTRQPGSAMSDPVIIAHDNPHTVDSLIFHGWILDPEAQLGAYPVYKWGHMRVILVTGNPTVVFQYRDTAVMIVVSPEDRIQLRETISLPVPGTQNTRDVSLEWTREIKVDDFATELDQCAICYQDWDKDHRPYRVPCGHVYGKNFVTDSMDSELKECRLLFLCIHLPTMSSNMSESPGHIMMSDSHGTQNVALPDVRDGRVGFQTKRVLDNAITVRRAPRRPQQVWVFIRKDVTARLWFGEPPVTPLNGVDLLTTKVKLARGDKDVGFAQSDTEEMRALLEHTWVGSNEVFHITPSRAHGNDYLNVVYAKGNPTLVLEHKGRNMIVIAGLEDHLLIHCVDKEGNEPTQQAELFKRVDDCAICLEHYDEDHVAVRLRCGHYFGEKCILAVIGHPSSASGARCPNCRAWIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHD3</accession>
    <name>A0A6A6QHD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_129786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHD3"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53182" checksum="3ECBBE896B0F4128" modified="2020-06-17" version="1">MVLISHPSEKPNKLSIGGQYHFISIKNLNDTNDRKARRIARSHAVTRGLEKKRKLQQQSGHNFFAVSFENNLSRPVSERKRRQTLVAAPLSLSADAPDPFQMLAAESPRLQALHSQHKAQQTAEPVFSLSDELVLQNFRSVLRTGRDDHALLSAFMLTFAFAVTTSSIDRQYLGYQNEALSSIRQRMSSPDRATSESTLGAILLLAGVEARLGMPRQVQLHMGAIQQLLDVCRRKGVYLSDGIKRAIFWSDLNASVLTGSSRVVDHTTFSALLWHRDKSSPNFYILPPGFQSQSYLLSDEFVEVLKDISALQCIRDSTFFGTEDVISMARVDNHQASIQSRLVSLPNRSSISECCHLAAYLCSTMLRCKLWRASTIPSHLSLQLLCKLQQANYDLLWDDRPDLLAWLLHIGGAFAPTGTIRSDYVVLLHSNRSTRLQGLYTSWPELLAILKQFIWSDSAFMSQVKAFWEETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHP3</accession>
    <name>A0A6A6QHP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHP3"/>
    <dbReference type="OrthoDB" id="4128781at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="21376" checksum="C53B8C8DD74D1B08" modified="2020-06-17" version="1">MSDFKDEKTLTTIPELHKDLPGPANKDHDPKLARAEEEILQHYKDFAYFCNFDCKDHPNWGKKFYDLDEAMYFDLMGSVQRPGFRPHYDNITPYLADAQIAFKDLEITAVTETFGYATALQRYWGVAADGNAFDFTFRTTSLVRKRDDGNWKYVHEHFSFPVNMATQKADLTSGLKIEENIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI87</accession>
    <name>A0A6A6QI87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_129112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI87"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="260" mass="28228" checksum="50D4AA460A6FC2EF" modified="2020-06-17" version="1">MEATYRDLAATIQSRAAQSKKRRFLVAIAGAPGSGKTTIATETIRIINQTAAATSPSSTPTAIAVSMDGFHLSRSTLDALPNKEEAYIRRGAPWTFDVDALLAFVHNLRVWADRYPKTSTATPESTSTSTSTSESAPLAAESSPEAPLLVPSFDHAAKDPVVDGVTIPPSAEIVVLEGNYLLLNQDKWRDIAPLVDLRVFVDVDLDVARARVARRHVAAGIEKTLEDGFRRVDANDYINGIATRDSLVEWVDVRVRSVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QID8</accession>
    <name>A0A6A6QID8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_566138</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QID8"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="14">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2491227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="529" mass="59033" checksum="9DB22F25E7EF28E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIP0</accession>
    <name>A0A6A6QIP0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_529454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1688907at2759"/>
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        <property type="reaction ID" value="UER00113"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:argininosuccinate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:L-arginine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
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        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2492082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="415" mass="46932" checksum="08A9DBE1E7CE24D5" modified="2020-06-17" version="1">MTKGRVCLAYSGGLDTSTILRWLIEEDYEVVCFLANVGQDEPWDEVEKKALKIGAKKMVILDLRKEFVDELCFRAIQCNAIYEGRYLLGTSLARPVIARAQIRVAQQENCGFVSHGCTGKGNDQVRFELAFYTIQPTIKVIAPWRLPEFCDRFKGRQDLLDYAEKHGIPVTSTKAKPWSMDANMAHCSYEAGILEDPDQSPPSDMWTMTEDPLNAPDKPTDITIHFDKGIPVKLVTPEKTYTDSVELFTALNKLGYVHGIGRIDIVENRFIGLKSRGCYDSPAMTILRLAHLDLEGLVMDGQVRSLRDQFVTHNWSIYLYNGMYFSPEREFVENSLLFSQKRVNGEVRLRCYKGSAYVLGRSSATEKLYSEEEASMDTLDNFSPMDTTGFISIQSIRLKKYGLQKAEEGEKLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIQ0</accession>
    <name>A0A6A6QIQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_99136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIQ0"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="129" mass="14132" checksum="76FF51E05DC09FED" modified="2020-06-17" version="1">MSNGLRGFWTFLLLNGPFSTFASPIVISLQPLWVTIVRSVGRYRQLLEVGDLESLIASCQGHAAARLATGSAPECFVCLEPHVNALRAACCATSCFIDTLAYQHEWPTSLSESSTAQKIKFLFPLLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL20</accession>
    <name>A0A6A6QL20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNJ9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="133" mass="15225" checksum="63C9F250BE3DE3F3" modified="2020-06-17" version="1">MHLLFYKLPNINIRELENILLRGISPYNRVTTCLIDAPAGMPNLVEGYTFSYSNNMDNIINLVVLVLYLYLVEASINLYILIARRILKKKILSLSALLSSISVIKKTAARIIRVLKPFFNSLYRAIRINIIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP43</accession>
    <name>A0A6A6QP43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_528773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP43"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2493473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="292" mass="31154" checksum="14D7CAB4BF68B697" modified="2020-06-17" version="1">MVSAGEKPAAGADEYDYEYFNVSFPQEYVAHVEINRPEKLNAFVEKMWLNISTIFTRLSHNPSIRAILLTGAGPRAFTAGLDVQAAAQPGSIINPTNPSADVARKANALRRDILAFQACISAVERCEKPVIAVLHGISYGLALDLSLACDIRLAAADTAFSVKEVDIGLAADIGTLSRLPKAVGNASWVKDVCLSARVFGAEEALRVGLVSGVYKDKGAAVAAGAELAGVIAGKSPVATVGTKEILNYSRDRTVEDGLRYTAVWNMAMVQTGDVKDAMLSGLRKTRPRFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPL2</accession>
    <name>A0A6A6QPL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_528233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPL2"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="615" mass="66782" checksum="881510EB20AFD49D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPL8</accession>
    <name>A0A6A6QPL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_463846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPL8"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="93"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="495" mass="53291" checksum="981307F887BA0C91" modified="2020-06-17" version="1">MPQDYNGSKPGLDFEPQRPQLYKLPTVDYHIPRFPNPEDSASATECGAHPALGDTSQPSPWESEKKDASVLEAQSPIHQDEVTYPEGGLAGWLVCFGSFSAMLACFGLMNTIGTFQAYLSEHQLKHMSESTIGWIFSVYVFLSFFCGIQIGPIFDAKGPKVLIASGGIMLSASMLLLGLCTQYYQFMLCFGILGGIGTSLLFTPAVSAIGHFFLLKRGYATGIAAAGGSVGGVIFPLMLQRLFPRVGFAWSTRIMGFIFILLCVTAQLLIRSRLPPKPGQSVSMDLRIFRDRSFAFATAGVFFMEWGLFVPITYLTTFALASGAIDPTFAYQLIAIFNAGSSLGRAVPGYLADKLGRFNSMVAMLGLCTATTMTLWLPAAILEPETPAARATIKGLAVAYAVLFGFASGSNISLTPVCVGQLCETSQYGRYYATCYTVVSFGTLTGIPIAGAILQATAGRYWGVVVWTGLCYTASFGMFIAARGCQVGWKLGVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ36</accession>
    <name>A0A6A6QQ36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_69214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ36"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="600" mass="68746" checksum="8CC90D0F8F3C240F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQU7</accession>
    <name>A0A6A6QQU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_582599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQU7"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="329" mass="37428" checksum="04B702922A292515" modified="2020-06-17" version="1">MMSNWLPAPFKANTMAPTPTFRFLDLPSEVRIEVYKILLCDASYRADHGPFEHPYPVPQIIETIPHSIKTKILTVSKSIYREAYDVMLKGNLFVRITSQGLDLENFLLVNRIAIITRTTRCVSAFNGYVMHHHLSNAGYSSPEYDLMLLYRDLDKFCAALGEGHKTYRDCQHSLDIFNIFSEPELPRKHQELLLRPYTTHLHSFPHLQITGVDLDLCQRALESIRRLAWSTPADVNQYFTQKHSLAVTQLLGNDYTSSAHICRYAIAQLCNLKNSNDWGLLLDIGGPEFSQSVVSLGLDFYSTLSRCTLWAMRFAAGPKKQSVRKAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQX3</accession>
    <name>A0A6A6QQX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_527618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQX3"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="272" mass="29974" checksum="B90EB3754054369B" modified="2020-06-17" version="1">MASNSAALASFVESTPPGELQDVTKAIKSILADDPSVLQSLEPAFEKYNEEQFTTVKLPGGSEEVIVSSHNSLGGGRYYDVANQSSFAFDHATQKASSVQSHVLESPQSDLVKSLLKSLYQHTLEHYPKSSLGVYPIENDSAIAVVTVANKYSPNNFWNGRWRSHYIISPSNSTLTGLLRVDVHYYEDGNVRLQTSKPVSVTLSSTSATEISRQIALAEKKYQEDLNRAFGSLSEGAFKALRRQLPITRQKLEWEKISGYRLGQDIGGGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QR86_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="235" mass="25173" checksum="7AE79211255CF98D" modified="2020-06-17" version="1">MGGLGACHIIKVGETCRTHEASTRLLPELWDQRRLMAWHGAWTRHGGVRLGGGPPEREASQRSGYNRPSHSLQRSICRPMFLDTALLCCWPSRAPSGYGSRGIQYLASAGRRCCCSSTLSIRCRAASANSTALCTSASRTSRGSPRLGGGRRPAYTAAHHEAFWGREPGRVSTASAAAFWNHSRFLVAPCAGTQGRKRIDPTVPYHGGGTPLVLSGSEDDAVSSLAVPPQHSPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS12</accession>
    <name>A0A6A6QS12_9PEZI</name>
    <protein>
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            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_527873</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="167"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="626" mass="71613" checksum="0042028D5FE3566E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSS0</accession>
    <name>A0A6A6QSS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495154.1"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="186" mass="20864" checksum="F307149612751AA3" modified="2020-06-17" version="1">MVRFVNGEPKYVWYSQHSNGEAFQYRILKKDKSGKRPLAYCANGSHAMYATPGIHDHTIPNLNLPLPFLLVDETNAGPLYDPLLNAWYYTYHPAVSTPNPTDPKSPPTVTPASFTPFLGGTPVSWLYFQGRWGDEQYPDKDKRQKQLAGNRKYVGGPTGPEDKQLDRKNVCPDNGQQCILRGVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QST8</accession>
    <name>A0A6A6QST8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QST8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="29350" checksum="471A61E45989C40B" modified="2020-06-17" version="1">MSEPGIGDSARGLPNNLPISTARVVSSAGDGAGSPNQPAVPLAPDVQCTFIFAFLQSTRALCNSPCSLGNPQCNRRRARRHSSHRQPPVRLGPTSKAALPCSITCAEGIVRGLSTLPRRPWHHERECPLSTGRGFVATSHGAEHHSQQQREGSNDVETSRQAARLAGSNHHGCERGLAREAVPAARTQRQPAAVAGQKDGRFACGGTPTAPPRGKPVMRAVTCALSGDRKRGSYSQGGFSCAGLAACVSSRPGPGAVVVAWPTTIECREARRRFARRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSV4</accession>
    <name>A0A6A6QSV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_540521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSV4"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="418" mass="46455" checksum="9C2E195681EB6085" modified="2020-06-17" version="1">MPLPYFHRPSPRLDDSPAPSSISRFSVMHNNVRSMLNGSSVYSDSPLPSNNNTPKLPLLGFLRRPHSPPPLPLANSEFRRDSTYSQSPLRPQHTAGSYIRAISSDNVARGPVAPQMVHTRNESHSSYDSIDPETEHIAEIVNHNRRRRRRRRRTRATPERNAWIRKRAERGVCFSYVKSPAARTKCTALLISGLFLIVVLTTYLSVALTRPHLGQEVHVLFIMVILCTTIFFCHSLIRLCMLALRPESDLPHIPSMTGPDGFKPIRPIRVHLARDEEIGVSHEAAEVEAEPEKEKVQMPPPAYGLWRSSVRVDPNLLHWQRADAAEASGALPPTRPPSVFPGFSSHPTSRSGSLSNIHQQAPPPAEHADEPARRDPRPPSYVSDDGVTYVVAAVPRSVAPSVSGMSDVHPAWRPGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU47</accession>
    <name>A0A6A6QU47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_562094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU47"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="443"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="744"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="814"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2494437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="990" mass="111121" checksum="B2C1B02EBD30DA84" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU51</accession>
    <name>A0A6A6QU51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_527130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU51"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="54"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="33990" checksum="B8A231AED6E4DCE5" modified="2020-06-17" version="1">MAGDPQETWRRLQMSLKNAQQSGRQFGGGPGKNALGGVAGLVILGGLGIVASNALFNVDGGHRAIKYTRIGGVGKEIYSEGTHIKIPWFETPITYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPRVDALPQIYRTLGTDYDERVLPSIVNEVLKSVVAQFNASQLITQRENVSRLVRENLVRRAARFNIMLDDVSLTHLAFSPEFTAAVEAKQVAQQEAQRAAFVVDKARQEKQATIVRAQGEARSAELIGDAIKKSRSYVDLREFENARNVAQILQTSQNKVYLDSTNLGLNISQTAVDKASRAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUD2</accession>
    <name>A0A6A6QUD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_560871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
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        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="71"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="29265" checksum="50531C9A2C0F98EC" modified="2020-06-17" version="1">MSKKVALPDAWDDDWESLADKQDTLPQPENPPAEVKVTKSERKAKHQELNKQLWDSAEKTDSLLFLEAKSNVPLKSTFKPSVTVLSRKPPPKVLSRNDATSGIAGLNLDDDEDSEEEARKRRAESVAEQRVRTQREREEKQRKYNEVREKLFGSSATAVEESQGRASPSRQSRGKGKGRGGRDSQPSSSNDQSPARAGNNQKRQLYDPTYSIKPNSVYIQRKEGADSGPGSRPATPNELQPIREPRGPSSSGRGGFGFAPRGGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVR2</accession>
    <name>A0A6A6QVR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF866-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_460599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="160" mass="18344" checksum="3DD2972834B554CF" modified="2020-06-17" version="1">MLALALTADLSGVTDLRPDDTEDNPFFYTFKVQCTSCRETHPNWVSVSRFEMNEQSGSKGEANFVWRCKNCKREHSANIKEAPKSYPLSSPPKIQNIIEFDCRGLEFVEFKADGDWLATGLESNTKFTAIDLSEGDWYDYDEKANDEVSIKDLKWQVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVX7</accession>
    <name>A0A6A6QVX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_336238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVX7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025693338" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12318" checksum="71F2B0DAF20B482E" modified="2020-06-17" version="1">MHLSLHCCAFDAAQTFFLLNLNVCLRCCASCMRFQPTICLSYAGQSAGPKRRSPVHKTSLCFSASTPSSDIVAQLHHIFLHTVIILNPAATCVYCCLSRTLESSLPSLISLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW38</accession>
    <name>A0A6A6QW38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_377596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW38"/>
    <dbReference type="OrthoDB" id="3785457at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="52338" checksum="FCDC1348A4F2EC89" modified="2020-06-17" version="1">MQPDAFLVHMASQLKPLLTLIKDDSLRSFSWDMGTRMPKSILSHISTKQASITSFSMTAAVHQWPDQGEASPYEAFRLAQLRKISWIADGNSHLFALRRLLSSSSGHLQEIVIDGKNFDPLQPFSTVSHNDDLAYKIPQETQGEREVLFPSLKKLSLSRVYLGNVRVPALPWLPPRWVAPVASLDEGDRADTVLAFNYFQLRSLKLEKCLRVDHLLSVLSGSSMSMELTSFELIVDSRVIPRHDHYRLGTCVEAFLESFEGLKNLYLDYSRLPNFFQAISRHKATLEKLVYQQREQYDNQFLWKKELSMLDLKCLGVGLKPSDLLPCLIQLVLGPKISEHTIYRPSVQLLHIRDGVQLTCKFKGPKRLEAEFPRALPEIYNFARWAFGPAGLPNLEILAYGDFAHQGRQPNILLCKSQLESDGETPYRQLTKKDVRLWEVVRENSDFLETCPETSLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW47</accession>
    <name>A0A6A6QW47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_460863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW47"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="527" mass="59298" checksum="4EAD57BB3ACD59B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWI3</accession>
    <name>A0A6A6QWI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">BU16DRAFT_572521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWI3"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="124"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="332"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="507" mass="56456" checksum="396872F5A17FB802" modified="2020-06-17" version="1">MTTSKPLRILDSSHLDFRLFVDALRKDGDLAEINEEVDPHLEVAAITRRVYERRAKAPLFNNVKGAKHGLFRILGASGGLSSDPQYAYRRLARHIGLPPTASLEDIIDRMLSAKKTAPIPPVHVSSGPCKDRRILRDDVDLTKLPVPLLNKADGGDYIQTLGINIVQHPTEPWTNWSIARAMIHDKNRMAGLILKPQHIARIFEQWQKTGKDVPYAIALGAPPIAVMAASMPLPSGVTEAEYVGSLCGSPLELVKCETNDIYVPANSEIVLEGTISVTDRGKEGPFGEMHGYSFLDEELMQPLYKVNAITHRENAILPISVPGRATGPDETHTMIGTLASAEIRQLLQDNGLPVKQVFTLYESQVIWAAIQVDRTALRALRTNAAELCNKIGNLVFRNKCGMQIHRLLVVGDDIDPFNFNDVMWAFATRCRPSMDEYHFEDVDAYPLVPYMSHGPGTKLTGGKVVGNCLLPLEYEMEQNWVTCDFANGYPENVKEKVLERWDRFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWK2</accession>
    <name>A0A6A6QWK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_371136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWK2"/>
    <dbReference type="OrthoDB" id="4840564at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="478" mass="54681" checksum="1CFE03EC230B4D8D" modified="2020-06-17" version="1">MSLAHEPGFCHLLRLPNELLIEILTLAVDYQASQFCDWQGTSWYKTPWSLTLVCRRISLLAYPLLYHTISFQSCTLQSLVPISKPAKLLLRTLCANPTLGPLCKEVKVNIKTNSQNETLRDAEFIALAADFDAASIILGKLPNVQTINSCGGFSHRKNVYPFPMWEMLSQAFNSMPLVSNLTLTLAPRRRQWNGLMYLDDLIELDFPALKHLHLDGVSSFCIHSIRGVGILPEALRGKRRTAPFTKLSMRNFRDTSSVLSALLTWARALEHFVWETSRYTSERSRTCRMVHRALEPHYLSLKSFKLDNIIFNDNIIDLTQYVELQDLHLSAFVPLETIGNHALHLAAPKLRSFTWDLTRTNVYPEPFNKSIVDGLRTFVDVILSQGCPLQRIDIIFWPRPEFYTETRCLYSTRPTSDTGLLSCSTEDWDCMHQLASELELLGVALTYDKPRLVTKEEYEGTVKEWEPFGKVWQPGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWL4</accession>
    <name>A0A6A6QWL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_571698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3870463at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="422" mass="46950" checksum="F83DEEBC66F785F6" modified="2020-06-17" version="1">MDLTHVIKEPAPSLGSVSWIGADDYDEGDEFHDRATKFFASVKWDVLASHASTIRNGIPCDFGEKFSIGHFNMVRLITFEDGIRWIARLRLPELKAVFGDREGLDYINTMKVEIASMKFLRSKTSIPVPTVHGYSVDATIDIGAPYILMDYIHGTVATELRDVKECAAYPSFGTQAQDRKFMQQIADIHVQLSQVTFDQVGGLYYDESTDEFSVGPELETGRGPWQLSTDYYSALADHALKVCVADADEDVQSSASLSLPVLFKHLMSVYGNAGGTFRLANRDFGAHNLLVNDDFDIIGVIDFDGIMAAPLEVAAQYPTFAGLDQQPPGNVENRPAAIETYKKSEIRRREYKEMVTLSEARLGIASTTQPALSTCLESDAAFVYHGMFKYAGHQKFVNDKWMDGYSRMLRQHIKSGASSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWR4</accession>
    <name>A0A6A6QWR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWR4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="353" mass="40779" checksum="859C1B85183024FE" modified="2020-06-17" version="1">MPLSLSGSLEAPREDFNRQPANTNSVQVLASEIDPFPLLITEVFKDDPPELPRSEIKAIFIYRHATTVIQQLPPELRMEVLKHMFRNHCDAKPRPKVDNTHEHWIEFRELGEFYHSHIKSEVLPDTSLEETDFGDWRWIHPRYTGLLAAEALQAVYETNPFRHSVVEVEHWLVSPRWHTIDVAPGRFVRDLSIHISPKDLDKISLRDVATRLTELPRLKHLTIYLGGINGGWKVLLHKLEDRKILADYLRNPLPIQILKQLRDTMVSRSVEVSVFMLSLSHWTHLISGLVQGGQGQDYVLMDIGFHLADERPPHSDMPVRQIGFTAWAMLQLLGGHMTENEFLRIEALLGYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWS3</accession>
    <name>A0A6A6QWS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="178" mass="18761" checksum="69B3AF22351F041B" modified="2020-06-17" version="1">MIPLLFSFGPALAALDSAVGGLHAIFLQTPHHICQLARLAHLLYRKDHSLPHIDLSISRIPPSSTPLTSQLPIRNTGIAVAAAGPPNPTLEGNHLPYTTKNIQSITKDAEASPGSVEGGACRAGHTPLAAYTPAQRQQLRDNLGQQVPRSLPGPLGHSDELFNGVITKEKGGGAQGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QWU8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWU8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="152" mass="17165" checksum="5A44486D0B3DDA25" modified="2020-06-17" version="1">MSAGQVGYFFSYQTMNRSVGEEVGHIYIHLRVTVRSSANPFRGTFRGDTPRSPKCFDTVTPDNLVHIVIVVDLIHRADTVVEDILSIETAKPTGFVRRALVAIQLAMIIGLEYLFYLHPRLVRRQAPNIVPMNLSSSFCRDISSLATLRYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXF7</accession>
    <name>A0A6A6QXF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_459377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2496926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="267"/>
        </location>
    </feature>
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        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="522" mass="57505" checksum="6663F85A5FBE642D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXK9</accession>
    <name>A0A6A6QXK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_608015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXK9"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="612" mass="68671" checksum="10F9FA8152C09E71" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 269.34</strain>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
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        </location>
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        </source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="790" mass="85857" checksum="A3A5993C5CADBAB1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYD1</accession>
    <name>A0A6A6QYD1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_508237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2642"/>
            <end position="3197"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3464"/>
            <end position="3790"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3786"/>
            <end position="3818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2011"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3210"/>
            <end position="3289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2011"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3239"/>
            <end position="3280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3818" mass="432847" checksum="22BE2BEF6002A388" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1M1</accession>
    <name>A0A6A6R1M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">TMP-TENI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_525354</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1M1"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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    </reference>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    </reference>
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        <location>
            <begin position="28"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="137" mass="15212" checksum="5488A652F6424977" modified="2020-06-17" version="1">MSQKGGTYRRSSEPNITTQFTSSPPTRNHQDSKPKNEDPTSDKKPATDTIALRSDSLPQPQNQHDDKTDDQDWAVIDSPPDESNTHSGGGFSSHFDLQLGWGRWKFTLLSWDLNVRKEHTHGDGRGLGRAKSVIGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2E8"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="232"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="372" mass="40686" checksum="732B93F09EBE2E1A" modified="2020-06-17" version="1">MGGGSDSPLVESKKEVLLILIPAPESVAAPSIDKLQKKFPNLEVEYINAAKTAAAWDLDAGIPKDVYKSATFIATVAALPPSPSLAPNLEFVQFFSAGVNHVMKHPIYTDTKIPLCTSSGIHPPQIAEWVFLTTLVQSHKYNGLYELQKRHAWERTEESNRVRDLPGQRVGVLGYGSIGRQVARVAHAFGMDVIAYTASPRTTPESKKDRGFIVPGTGDPDGSIPSAWYSGTSKEDLHAFLKQEIDLLVVSVPLTPATHHFLSTAEFDILAASNPNLTYVANVARGDLIDQPALIDALKSNKLRGAALDVTSPEPLPADHPLWEAPNLVLTPHVSGNSIRYFERAFQVLEENLGRRERGEELVNEVDRKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2S9</accession>
    <name>A0A6A6R2S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_548778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2S9"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2497707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="194" mass="21657" checksum="BAA2D24151CA599D" modified="2020-06-17" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLRDDAAVCSKLAKQRMQPVRREDGERMAKELGAVKYVECSALTQYKLKDVFDEAIVAALEPPPKTKEKKKCRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R344</accession>
    <name>A0A6A6R344_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_455424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R344"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="148"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="414" mass="46786" checksum="110AA9C24C6FFCB0" modified="2020-06-17" version="1">MSALRVSEWQKLPVSLKELCINTTLRCGQSFRWRKSGEDEWSLALHGRILSLRQDSQHLHYRASFPSASLAPPTPPASTVPFAAESVNQDDDDTLALVKHYFNLTPNLAQLYDQWALADPNFRKRAPKFTGVRILQQDAWEALIGFICSSNNNISRISQMVHNLCLHYGPLIGHIGETPYHDFPTPMALTGPKVEQHLQKLGFGYRAKYIYKTAVMVEEKGLDWLQDLCNPENPPLGVDPKPAGELVEGGREGYRRAHEELLALHGVGPKVADCVCLMGLGWSESVPVDTHVWQIAQRDYKFGKGKHSSLTKATYDAVANRFRSLWGKEAGWAHSVLFTADLKTFSERLVAKAEVKEEAVVKTEVNGIKQEADTVRIETITEKRVKRPFVKEEHQVLEVKEEKVTRKRAKRTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3M6</accession>
    <name>A0A6A6R3M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_524494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3M6"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="26322" checksum="75356F8DA06E8754" modified="2020-06-17" version="1">MASRLARSAVATARLRPSLPIRAIPSITAQLTSARYASNVPVEDPKKKAQSILDSLPGNSLISKAAILSAGAGVSIAAISNEIYVVNEESIVMLSLLTIFWAVGHYGGPMYKEWAEGQTAKIKGILNAAREDHTSAVKARIESVQDLGGVIDITKTLFEVSKETAQLEAKAYELEQKTALAAEAKTVLDSWVRYEGQVKQRQQKELAEAIIAKIEKELENPNTLKQILNQSVADIERIVATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3T0</accession>
    <name>A0A6A6R3T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_299416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3T0"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="53"/>
            <end position="153"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="320" mass="34604" checksum="5EE8B9E026776B34" modified="2020-06-17" version="1">MSTTTPDKDNTFRKYAPEDAARYASFRIPYPPKLINTIISTHESTGGHLTTLLDVGCGPGTATHSLAPLFTNAYGADPGAAMIEAAQKDAPITASGAPVRFFVSTAEDLLTSIPEIKPGSVDLITAATAAHWFKLPGFYAAAAELLKPGGSIAMWCTGPQYCDPYTTPNVAAVQAAIDMLQEEVIAPFEVEGNRLCHDLYAKLDLPWTIKDADAKTQAALDDFDEGAFQRIAFNEGGELEPGQEFVRGMKHASLEMLKKVSGTASPVQRWREAHKEQMEKGEVEDCLDRMARVIKEAMGGRDWIDGGTSLVLLVIKKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R413</accession>
    <name>A0A6A6R413_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="31"/>
            <end position="159"/>
        </location>
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        </location>
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            <begin position="65"/>
            <end position="74"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="290" mass="31634" checksum="31B37C421FB20EFF" modified="2020-06-17" version="1">MSIRLHQHGQPGLLPHEGAGLVMLAGIFDKQQARRPPQRSSPTTLQRASPQSIPRVDGNRDTQAARRQSSSWLNDIQPHRKVSRSGASQTGNSQPPTPVTEQGMNQPRVGPVSFPWNAGVFTSTRDDLPSSTPQCPPPPPRLTPVKATRRQVPQHGQSGLLPREGARLVMPAGNGAFFFSGLVGLDSFPAMEPGRPCLRVMELLGTWPAWSTLTSTVPEHGVYVMFWCGGPDRLGRLMREWLGMAVTDPDHRTEHGVYVMCRCGGPGRSRRKTGVDVMAMAGLVCYDDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4D0</accession>
    <name>A0A6A6R4D0_9PEZI</name>
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        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_558358</name>
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    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02714">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
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            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="704"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498287.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="868" mass="95914" checksum="F297778E6890D8D4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4K3</accession>
    <name>A0A6A6R4K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trypsin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523796</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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    <dbReference type="Pfam" id="PF13365">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25536" checksum="5264D708D1931B9C" modified="2020-06-17" version="1" fragment="single">MDSKAPPRRQKHTSTSSTLAPEPTQRRTRSSSRKEQDEQSKSKEPSPSQPASSTISILPSIPTPIPPPPITLLSTLTTTTTGLSTRALALLRQKRALLLSKSTQHRLASAIAATLVFAQEAGGTAVCVHPSGLLLTCAHCVAEHPSELSLSARHWLLFSSGQVVEARCVAYDHQRDLALLKIVAASAPLDTGSAFPCVALAPAEPKAGAKLLCIGHPGSEDLEADVGGVPTGYDVLHVSYGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5E8</accession>
    <name>A0A6A6R5E8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_524047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5E8"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="211"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="516" mass="55030" checksum="6CF6453F72C536CB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5Q4</accession>
    <name>A0A6A6R5Q4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_285854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5Q4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="42"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="51781" checksum="74A675C6643EF0C9" modified="2020-06-17" version="1">MATTTTTANGAVHFTQNAPSNTATNPATPENTSQEEQAAILASVIALTALFSTTVEALTLVHPSASTHVQKLALTRLGIQQGRLLIFGDAVGISSPPASIATHFVPSHAGLSNPDPEAPINFGPRDARLDEPEMRKQVEERLDAIVSRPEKLGREELMSMYGLKAPKRLSGAGAVGEQAVDMNRLEAFREKYALLQDLSHKKARIPPRRGMSMVAQHWTVKDVEKFNAFIGMVKMQVDQLIALFGVEEQVERGMKIDIKSLGWHPDLSGAQMRKDWSKLKLIRQACEGNYPAFVQATDTALKYINQELRGNAKLPPLDYAAKEETPTAPAIRPESPKRPGLLKLFSGSAWSGKKKKGPQRSLSTAGLKKPLEDTPRSMSEDMQKESLADLEPVRSKSLSAMSGKAPVTIDSVLVQSSSNDSNVPVAEDNPDDAQYQLSQVETAKSLVDRHDMWDGPGRVPTKDIRWAAKKNAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5S0</accession>
    <name>A0A6A6R5S0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_524149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2499694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2544694at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2499694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="519" mass="57400" checksum="D610389A96250711" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R657</accession>
    <name>A0A6A6R657_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_536122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R657"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="110"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2499834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="298" mass="33183" checksum="55EF85E13A58CFB3" modified="2020-06-17" version="1">MKRRVEDGADQIHTGDEASRSESHFAIAPMSDEPSQVQPRKKRATLQTRPEEATVAQEIDHIDLVCSINALSASEFQFRFLPQESPLLSFTPNTGFGSDNPVNSLMISFKVSSEMSEPDLEGCFSLIEETSSEAYRKSVVRWRPKAKKEEMRDPDMRYLIVRVPDSLHEASSSADSHHPVHGFLSFMITHDDDYEYAVLYIYEIHLSASLRGCRVGAHLMHIAETVAQGVGLVKVMLTVFTSNVAAAQFYQKLGFSKDDTSPEPRVLRNGLEKPPDYLIMSKDVVSVTKASATEAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6F8</accession>
    <name>A0A6A6R6F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_534768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6F8"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2500141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="41351" checksum="8CFEEDBE7343794C" modified="2020-06-17" version="1">MTEVSSTRLYLGNLPRNATKAEVEAHFQTHGTGEITEIKLMNGFGFIEYKDAMDARDVVPAFHGSDFMGERLIVQFARGSRRTENFAHQERAAPRPRRTPYRMRISQLPVETSWQDLKDFARQSGLDVVYSEVGRDRDGTGFVEYETAADLKNAVEKLDNREFKGQQVRCIQDVSSPPPQPPFKPRQPYPPQGMDDRGPRDRFRSRSPPPGGRRGYPPAGGDDYYHDRRGAPPRGYSPRRDDYYHDRRGAPPRGYSPRRDDYRRRSPPPRDYYDSRDRYARASPRPRGPVDEYGAPPRRYPDDGYDARGAPPRRGYEADPYVNGHARPYDGRPPSPRGRPRSPARAGYDDNYVPRPRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R701</accession>
    <name>A0A6A6R701_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="10">AMPSase</shortName>
            <shortName evidence="10">AdSS</shortName>
            <ecNumber evidence="10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_523123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="10"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R701"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="156"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="270"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2500321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="281" mass="31621" checksum="17895E8B23D04379" modified="2020-06-17" version="1">MTRSGIRIADLFDEEVFEAKLRRLAYGFQKRFGDLLKYNVEDELSKYKELREKLAPYVIDQIPLLNDAKAKKSQILVEGANAIMLDIDYGTYPFVTSSNTGLGGVLTGLSLGWRSIKEVVGVTKAYTTRVGSGPFPTEQLNEVGEKLQGVGREVGVTTGRKRRCGWLDLVIIKYSHDVNDYTSLNLTKLDVLDDFEELKVATGYSYQGQKLESFPANPELLAKVDVTYETLPGWKKPTTGAKTFYDLPLNARKYVEFIEKTVGVHIKWIGVGPNREHMIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7A2</accession>
    <name>A0A6A6R7A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_241335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7A2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025628880" evidence="7">
        <location>
            <begin position="19"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="598" mass="64729" checksum="73799057835E6965" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7M6</accession>
    <name>A0A6A6R7M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_436142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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    </evidence>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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</entry>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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        <property type="protein sequence ID" value="KAF2500803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_trans_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="642"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="1227"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="1418"/>
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            <begin position="109"/>
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        </location>
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        <location>
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            <begin position="1440"/>
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        <location>
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            <end position="1462"/>
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    </feature>
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        <source>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50893"/>
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        <source>
            <dbReference type="EMBL" id="KAF2500803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1475" mass="164854" checksum="88FDEF7F257E1142" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBK5</accession>
    <name>A0A6A6RBK5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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        <source>
            <dbReference type="EMBL" id="KAF2500837.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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    </feature>
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            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="529" mass="59999" checksum="7B7AD880D48D97B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCH0</accession>
    <name>A0A6A6RCH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_532853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2502505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025577439" evidence="3">
        <location>
            <begin position="24"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="90"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="429"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2502505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="542" mass="58220" checksum="944ACBBDF35BB847" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCW9</accession>
    <name>A0A6A6RCW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_203507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCW9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="83" mass="9097" checksum="78BBBB28182C5110" modified="2020-06-17" version="1">MPLSLLTTIASLLLHQELDRRVYLSNLGKQPTQCSIVCLVPSSRSVVPALAHKQASSRTSTDLRCYKTQIETESAFSTSSAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDW0</accession>
    <name>A0A6A6RDW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2502624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="170" mass="19129" checksum="FCB1544213D68E4E" modified="2020-06-17" version="1">MGVPFYNLTVPVFVRAFANLSAILKIAEAHAKTNNIDPSTLLEARLYPDMASLPFQIQRCSDSAKLAAVRLSGAENVSMADTETTFEQLHERIQKTVDFLQATDEKAWEGKETFLVNFRMGPIEKTYSGERYMLEFALPNFFFHVTTAYDILRSKGVPIGKMQYLAGGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RE40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE40"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="135" mass="14543" checksum="ADB07D2E6A09D6E7" modified="2020-06-17" version="1">MPLSTNPAPPSLFRCASTRIADSPAAFHDCLEKFPGWLLGRAHRSASSEDPFIANRYSVLMSICGSTALVSMCQPRLVSTGHMAIASTMPASSLQPPASIHPSRDAVLIHGREPPAWPPARRTAQNCRLLELGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFK8</accession>
    <name>A0A6A6RFK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_532870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFK8"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="442" mass="49601" checksum="C44917135A8C1230" modified="2020-06-17" version="1">MESSTRGRRRRAGTRRKTGCTTVRLSHCQSFTCKARHTRCDEKKPVCSNCERLNLQCRASEFITRSAWCEPNVEPQVSTDVDILPDAQPIEPPESTWDLFDTSLPDSTGASCVSYAARPSPPKIMVPMHPKVPINLEPEMVQLLTAYQRGVAGWMDIFDHDCTYERTISQRALDSELLLRCICAFQAKQLSLLPEGEVWAPVAARYYVQALGLFINQVDPSAPSEEALTAIMMLSSYEMIAAQGYEHRHHFLGAGLVIKTRGINASSTGMDRASFWVYIRHEIDVALTNECTLSISPKDWNVDWVKIDVQEDEIANRLMWFVGEAIDLIYGEDPDSGIRQSLLDDVQKWKDALPVSFRGVRYGCSTEEGFTRTYFAIPAAATAALWYHTVMILLKAEPVPRELLDDEIEEVQANAFEIGNIALSDVSKSVRSFSALPLYFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFS1</accession>
    <name>A0A6A6RFS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_569089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFS1"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2503202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="16664" checksum="C1F0A23A8463CA21" modified="2020-06-17" version="1">MADVEMDVDPPQANSPEAKPASETRTQAGAVAVRSIEGWIIMVTNVHEEASEEDLTDLFGEYGEIKNIHLNLDRRTGYVKGYVLIEYPTLAEAKAAIEGANGEKLLDQTLAVDFAFVRPPPGKGQAGKGGRGGAARGGGGGRARSRSPGEARDDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGT6</accession>
    <name>A0A6A6RGT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neutral ceramidase</fullName>
            <ecNumber evidence="4">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_545914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="4"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGT6"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <alternativeName>
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        </alternativeName>
    </protein>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB58"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="193"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2489294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="643" mass="72656" checksum="7BBA31AA6C288B9E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBD8</accession>
    <name>A0A6A6QBD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_218339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBD8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="167" mass="18604" checksum="BDFB287A3578D48F" modified="2020-06-17" version="1">MQRAWQASSGGTGPCSVKNSSRRHDGAWRSRVQRLLGHREAGEEAGDRWQEDATKVFNNVHTKIAIPSLPLAQPSRVLCTISASCACSVVICEPGRFYPSLVVHAAASNHQLQRRHHCCWRNQLHRTQIPHPRLVRTAARRLLSSPLLSMPPRHCHPPACGRASCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBH0</accession>
    <name>A0A6A6QBH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_532017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBH0"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="226" mass="25247" checksum="16AF14D39EF8BA38" modified="2020-06-17" version="1">MSGWGMGWFGGGTAKQKDAPKKAILQLRGQLEMLSKREKHLQNQMAEQQAIAAKNVTSNKNLAKAALRRKKQFEHSHEQTQSQIMSLEREIYSIEASNINKETLDAMRNAGKAMQQIHAGLTIDKVDQTMEDLREQHAISEEISEAITQSVGNTGIDEDELDEELAELQQEELDNKMLDTGNVPVGDQVHRLPTAAQGELKGKAPAQAEEEDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCN1</accession>
    <name>A0A6A6QCN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="392" mass="44087" checksum="8A3E3BC77C25EF36" modified="2020-06-17" version="1">MAWASLLFNFQSHHQIRTLPRTRNCELLSLSPPPYYNPTSKPTPPPQPPAINPTRACRMSPRSDCPQQQSDRSTSAVGRPPSPAETTENHNNSLPDLPQQAMANRSTADDVRGFVALSDDGILSDDGALSDDGILSDDDYFDDDDAADMAFTHERNSELSDRPMVKEFFNKLPNLSTLADPETRSWLGDFPSDIWEDAIPLFTDGDPKEAASTDYQLHPCYTRLKLRKAALQPHPDIFRLCTRSRCIYKKVVLGIGCLFVNIQTNNGRKSKWTGYEMFVDQNLRLLMVFDSGSLKHAMKDWFPFGCRLSLSRPQNTSNKQHNCFKILEEAPFGWAVVSDSLQSIHQVSFDDVNKMVADTFQNTTGVIQADQLEIHYINTIFPDVRPKSASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEF5</accession>
    <name>A0A6A6QEF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_516647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="290" mass="31241" checksum="7AC413727F80F074" modified="2020-06-17" version="1">MVQTSDLKASKLFSVQDYVCIVTGGGSGIGLMAAQALAANGAKVYIIGRRLEALEKAARSHEPDQGAIIPLACDVTKKEDLTKLYEEISKKEKYINLLICAAGISGTKVEPNEESASKMKEKLWKEETFEQWNETYNTDVTSVYFTTVAFLPLLQAGSESHGHLSASVIVISSMSGIMRHAQGHFSYNAAKGGTVQLTKLMSAEFQKLKIRVNSIAPGYFPSEMTTQSSGEDQKSELPDETVQAKGHVPAQRAGSDEEMAQAVLFLTKNAYVNGEIIAVDGGVLNVVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEJ5</accession>
    <name>A0A6A6QEJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_596501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEJ5"/>
    <dbReference type="OrthoDB" id="10358509at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="255" mass="28153" checksum="F869194CAC0E631A" modified="2020-06-17" version="1">MTTPTISLMLPPCLPPHPSTTLTMSFRRRPQTRARPPKSTHTHGTYASPITLSSSPSTPSTATLQADTPIHVPPAPSDLIPVPTPLPYNILIGLRAPLFVNRAADPTTLLPELLRLAALRPQVLDYTYVGAHIPSNPVVFLCIQDFYGRGRSSVGFFSPMVEESWWEEWGDGAAEMFFTECSDAELAASEVMVAQIGEDWGKRGGGEAERVEAGSQGRGGARWDYRRLQRVVETFWHARLDEALVTRRPWMCGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFV5</accession>
    <name>A0A6A6QFV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_142557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFV5"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="193" mass="20927" checksum="4B752271C64DB529" modified="2020-06-17" version="1">MSVPTFSCPACSYITISRETVPKRVHWPTSSPSPTSPLTKSSTNLLKTITMPPLTPSAITLPAFKELLSRYPAAVPPKLHDLDTARFTTLPATVAKRRDQNSGDTWLEKAEVLQLVEWKLKHGTFRPTLLKLVASNPAERIEESTRNAFAALPDTAAALPLLTPLSGIGPATASLLLAVAAPERAPFFSDEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGD8</accession>
    <name>A0A6A6QGD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGD8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="31230" checksum="63C4D38A9D8E3A3E" modified="2020-06-17" version="1">MPSESTRNNGRSGMPSQPSHNTGRSYQESSRTTRQDRRHPDDPSRLLDEAQHSLREWDRTLASMDRIQGEFDAIQGEFDAILAECNASAAKSDRDYVAFVKELAELEIERQERNRPGSRRPQTSHSQARPTFAVEPDRARGLRDGLAREVARVAGVSQRTTVDSRSTLTQATTRRQDEPSRRITGSSQQTTGDSRTTRAQGTTRGKHEPSRRIAGSSQQTTGDSRITHAQGTTRRHDEPSRRIAASSHRTARDSRPTRTQDASRRQDESAHRNGGSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHH6</accession>
    <name>A0A6A6QHH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHH6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="67323" checksum="A5B317A051DDA174" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI12</accession>
    <name>A0A6A6QI12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase UcpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_102195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="268" mass="28155" checksum="1BDBA89D63839A88" modified="2020-06-17" version="1">MSFALKGVAYITGAASGIGQATAYAFARQGVRSFALLDRNPPTETIKTLESLHSSLSIKAIELDVTSEAAVNDSVAATVKEFGCIDYAVNNAGIGGKMALTEDIPLDDFQRVMDVNTKGVWLCQRAQLRQMMTQERPTNPREYRGTIVNMASMYGIVAANANVPSAAYVTSKHACVGLTKADAVTYAAHGIRINAICPGYVATPLVGSSTAEVLSDKSGVMAQELAKVPLGRLALPEEIGDAIAFLSSPASSFMVGSPMIVDGGFTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI99</accession>
    <name>A0A6A6QI99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F420-dependent NADP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_530152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI99"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="34155" checksum="A26B5CCE12A4E03C" modified="2020-06-17" version="1">MRIAIAGTGDVSKLFVEEFLKASHEVVVLARGPREWFTRPDVALRQTDYSVSSLTQYLEDCDGLISAIQDNEMTNVNVHLAMLEACKKSPKCKRFIPSEYIGDVEKYPEQPEFYFANHQPIRDALAAQKDVEWTLFNLGWLADYLVPQKNRYIRNIDDAHPVNFNDKTMIIPGTGDEPITCTAVRDGAKAIAHLFNAPAWEPVTYISGEATTWNQVKDLLAKHGNQLKISYRPKAELMDIVSNPTSHTPDDLVTAQFGMWSASGSTRVPEEKAAAHKEKFFAGLQFQSIEEILSAVEKDAEFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIF0</accession>
    <name>A0A6A6QIF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_529379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIF0"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2491992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="335" mass="36113" checksum="17D27239CFBE0EDB" modified="2020-06-17" version="1">MASATQLPKTMKGVWIEKTGGTEVLQYKTDIPVPELKEGEVLVKNEYIGINYIDTYFRTGLYPPPNFPYILGREGAGTIAALGPKTPSHLSLNASVVYMNQSAYAEFTPVPATAVVALPPSISPETAAAASLQGLTALTLIRDAYAVQRGDWILVHAAAGGVGLWLVQLLKAVGARTIATASTEEKRALAAKYGAEVTLEYFDYGDVFVKKVLEVTGGKGVSAVFDGVGKATFDASLNSLARKGSLVSFGNASGAVPPVTISRLTAKNAKLLRPTFFNYISEEGELEKYSAELWDFIVKDKMDVRIHEIYPLEDVARAHQDIESRKSTGKLLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIK0</accession>
    <name>A0A6A6QIK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_529325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIK0"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="422"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="596" mass="67096" checksum="5D9356141DC36528" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ64</accession>
    <name>A0A6A6QJ64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exopolyphosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_467867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ64"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="6">
        <location>
            <begin position="268"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="433" mass="47725" checksum="D91C8AA976B34FE9" modified="2020-06-17" version="1">MSIPRRSLRTFLITAKDAIRTAVDNSQKITFVIGNESADLDSLTCSILYAYLRSSCPPPHAFTPLFVPVANIPASGIQLRPELLALLPHADIEEKHLITLDDIPELSSIKSRLRPENTKWILVDHNALQGTLGSIYSERVGGVIDHHDEENKVSADTADEPRIIEKAGSCTSLVTEYCRGAWDAISDTKLSSGAAHAQGDEAVGDGAVRTLWDAQVAQLGLASILIDTSNLQSKEKTTGHDVTAAEYLEAKIMACTQVAGGFDRTKFYKEIDTAKKNIGGLKLQDILRKDYKQWTEGGLKLGISSVVKSLNFLQEKAQAEANGRSTADAFYSAVREFADEQELDMYAIMTTSTSPEGNFQRELLLWAFTADTVATAQKFETNATGELGLESWHGSDGRSHDEDSEKDWRKVWRQRSVQHSRKRVAPLLREAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJJ7</accession>
    <name>A0A6A6QJJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_574278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13679">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="672" mass="74182" checksum="26A0656A708D855D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QJL8_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_541384</name>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="165"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="201" mass="22135" checksum="FBC8ABB19F7E498E" modified="2020-06-17" version="1">MASLDHHQAMCEMERQSREEPSLERPSHSDRNGDGEHQKAFKRNGVPNHLDQQQSGKTTLSGKVLYPSLSRRTEPPTTSLHQNACRDGPPGGGCRRYTPVTNFQITCTNLRDQLANDPPLGQALQSIQAPALSPPGGSQDSQEQPSSTHDLYNDHRNTPDSDSKNHPFNRSTVQGARHSVGSYGVDRTSLQNSKDDSGTRR</sequence>
</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
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    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QKW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_620030</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="123"/>
            <end position="141"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42932" checksum="F998AEFAEC37D2BF" modified="2020-06-17" version="1">MRQLGATRLQTMVPFPGRIGHALSGASMWLSQSHAVGRMGLHAGSQTAATRSQFTSVTRGVGLLDDAGRSVGRQRGVGGGPSRWLESDAIYSLLTHAVVNVQVAAELVPQIWRNWRTKKTDGLPGLMVMMWASASVPFGVYAVVQNFNIPLQVQPQCFGFLSLVCWGQTLVYHSGWRVWTTTLTVGVLACTFGGLEALFICVLRGPYARGVSWPLTLMAIVASVIIALGLIPPYFELAKRKGRVIGIDFIFLTVDWSGAFFSLMALVAQHTFDYLGGILYIICLLLELGIFASHISWLYRTRHIRRLAKKAGKTYDEYMADQRETAEPTRLETGDPTFRINEHDTEPPESAHETLRRPESCMTKEPDVGADLQDYGTVDLEKGLQREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLI6</accession>
    <name>A0A6A6QLI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_95446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLI6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="189" mass="21111" checksum="6B87259B96975834" modified="2020-06-17" version="1">MYHLHSPTTRLACGRYTRQSFPPGTLQHHGFGFPLRRITDVAISEQCSQLRLTRPEALASETRMSAISSTTTLSAPPATQPGSHHAQFSKRAVCRSTKTSIHDVQIFSISTPAAAARTPLRRPSRARVDHHTSKKARAQDVVLPLLFVDMLDVVAPYRGILLGFRHQMLVGLVWRVRVGWASNSILRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLY1</accession>
    <name>A0A6A6QLY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_71796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLY1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="16756" checksum="C2CAAA3BAC2B070C" modified="2020-06-17" version="1">MEPSNPPMQIYDFSKPSTSIRSSPAPSSTQPTSHVTPSTQRSSDQLISLLLRRPSIRHPTPTAGHPIQHASTNAPSRSPTKKPSPSKSGNPRAHMYPIRNVTLNSACVRKRAPLIQALPHTIPPLTPHNACSRYARDEKRAQASKQSNHPNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM66</accession>
    <name>A0A6A6QM66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3648838at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="489" mass="56680" checksum="12D76C4C7200E538" modified="2020-06-17" version="1">MAEVMPLPNELWMHIFSFLSPPDIKQARLSCRDFKAWSSGFLITRVIFARRRETLDTFKQIIEHPIFRLSVRELVFDASFYMDCTADDYFRQYVSLEPIRVPLNSPFYQQVFSGGTEYRQRYLEERGIRLGEDKRLLEQTFSTLPQLRQITFADFLYTIPEGSNCMQHVLDRFGAGRYVMPPSRLPNDITFEGYGDDWWYTPYNDLLDLIRLVSKSTATITSISIPRPPVQFHRLSGTTGPCAYSSGQRASYIQPYSLPIDFFTLSDPDYAALSTVFQRLQHIRFPIGAHFHKTAHLTAPNPPRIAALLANAKHLTHLMLEGPRQHQFRGLRCRERPLICESCDPKAVEMFSFASLFADKVWPRLTRFDLRRWAFNTDHFEAFVMAQPTLKELRLCEDTLLGGTWTEVCTALSRRICLSGVEFSRLSYSLQVDQLVELTENDARDVEAVLLGDRPNAIEREKGMYPTNRMRGEPRYLRKAFHWGVPRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM76</accession>
    <name>A0A6A6QM76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_528512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM76"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="641" mass="70951" checksum="7A80310F7E901FC9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM94</accession>
    <name>A0A6A6QM94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_563416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM94"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="99"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2493244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="53349" checksum="8DDB3A52AF0F97CD" modified="2020-06-17" version="1">MTTPQAPSQSPSTRLQEHLTPSQQIEELSDSEGFEDTMEPATTQPLPSFPKLQMFESPLRDELVTDSSEIETETLDDILPFLDGNPYNFELNSFGVPKLQRLEHIIFLHKALRTYPAQFAAMDAARPWLLYWSLQGLTCLNEDVSEYRERVTYTFSAAQHPMGGFGGGHGQLPHLAGSYAAVLSLIIVGGKEAYDMIDRKTMWHFLGNMKQADGGFTMAPGGEEDIRGAFCAMVIVALLNLPLELPPTSPARIKGDETFLTKLPEWISRCQTFEGGIGAAPTNEAHGAYAFCALGCLALLGSPEEMLNKHLDVPALLSWLASRQTQPEGGFQGRTNKLVDGCYSHWVGGCWAIVEAAVQGSKDGVGARLWRREGLARYILACCQGQKGGLRDKPGKYPDAYHTCYNLAGLSAAQHRYVYDYEKNSGTTAAPLSAAFNWTVADVVEEEGKIWDREDTVNIIHPVFVVPWGQAEAARKYFEGKAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMF3</accession>
    <name>A0A6A6QMF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_619643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMF3"/>
    <dbReference type="OrthoDB" id="4152607at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="471" mass="53225" checksum="605B88FAE4DA8617" modified="2020-06-17" version="1">MVPPQLFRAYSMSGSRSTKGFCANTIFQPPTDRHQHRDCRDSIYDMNQGEITVMLGHHLAWHDRNDDDLTSFTNSFLFAVEHALGSRNKQFDCHIAVIDTAKAMTVPTRTSAGGQPIHIHPALTVYVEAKVGAYAFWGNRDGGRLHPRKFTHEFVTVGVVKYTEIYHHISMNDLIKKGLFKIYPEFDIPEGFKTTGLYTRLIALREALYCSSKLKSKVIPADVECAQTTSDSLEGDLGNTEWAEVSLTVGFQENATDPVPEQDLEFAVDVSKSMAILQPGECLDDVKAPLNLVLAILSLRLRERGSPRLINYIRVNYERQDLESLIFPNISHVADNLPEQIQYLDLIRDACDALSVEMIPDNILSYGIGIAGHEKFLEEDERLKRKRSHNLWKKKVDKPKKRKKEQTSDEQQLKRQKSDLATPDRAVRSSELEIEQVVQDEATNEMAKTPTSEHDAAELIDKASEGNNENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMR6</accession>
    <name>A0A6A6QMR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyadenylate-binding protein, cytoplasmic and nuclear</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Polyadenylate tail-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_464892</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMR6"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 269.34</strain>
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        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
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    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPH4"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="18646" checksum="21EAFC6261EB5F66" modified="2020-06-17" version="1">MATVETLYLPHYPSYPIYISLFKNVSNAKFLRQQLLEANAAFEYAFLDGTMILSPRHLHAATFRALNDSVYNRLKSRNIHSELVFSLSPNNNIADAYRRFGIQDSTTSLLAIKIPLSNPEITAESVSKHLGDAVEGESVAFGEEALKGVTDVKALRKGVILGMMALKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPI5</accession>
    <name>A0A6A6QPI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_539718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPI5"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="246" mass="26642" checksum="70875F62405EDA99" modified="2020-06-17" version="1">MPGKTYLITGANRGIGRGMFNHYVAQPSNTLIAAVRDVPGSQNLLTLPKGQNTTIILVKIDSASKTDAYDAITSLRAQGINHIDVVISAAGIAKLNTIEDMPLAEYEEVLMVNAISVMLLYKAALPLLRKAGRPARFVFISAAGGSLNKMGKYPYPNASYASSKALANVLVVKMGMENEWLVTLCIHPGLVQTDMGNAGARAFGLDKATLTLEESSRNTAHIIDNATKEEHSEKFFNETIDRIHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPN2</accession>
    <name>A0A6A6QPN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_64435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPN2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="188" mass="20106" checksum="792F77E79873E713" modified="2020-06-17" version="1">MPYPTATIRPRKFSQTGTPTQFPVNTPPLVSQRRLVVSAPHATGSSQALQCNRASFLCRYSATIHAKRGQTHLTDTTETPSATISPPSWHLSRPPPTLAPPSCVTLSCTLHTCINHAISKIKKLTPLHRVGHPSTRITITPSALTTNPTAPATIPPAPHPHCLTVLPSFDPINPALPLPGRPSSTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPV1</accession>
    <name>A0A6A6QPV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_527545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPV1"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="76"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="646" mass="74410" checksum="770597EB83457F25" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ57</accession>
    <name>A0A6A6QQ57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_512506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ57"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48714" checksum="E71A17E1BEA98059" modified="2020-06-17" version="1">MILVNKSLDTNFRRISQLFYKKSLRSLQEKQTQEPAEILEQTAPEEPKEQSTQHIKHDSAVYTDDSAPLPTNLPAIHKLPVEIIQEIASYLSRHETASFCLSSRFTCYAVGTQALHTLLRAAYNSKFDRRANTMILERAFPSHWLCAWCDKFHRHDHAGGPQHFSRETKRECAQFNSFLRCGRGFTLAYHHVRLAMNRHLCGPEYGIPLDEFTFLSKQTAKILRVDCQMETSTMARIVANQFLLHAACTVTIPLRLRPQPGIAIEITRAMPQVVVGHRSKEHRHRDLVWVIQLFLSMMPPQEFFQSDVKYCGQCSTDYQVTCCYRGLPHSNLRTIEIVVEVWRNLGVGRSPFDSLWRAHGETQGQKVVAKASSWSPVDKSQAGVIKEAFQKEGEPERLGQFGTLHGDALLPKIWDEMKNAGSHYGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQD0</accession>
    <name>A0A6A6QQD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_550501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQD0"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="156"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="263"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="422" mass="46384" checksum="B2DBC6368E8C8DF3" modified="2020-06-17" version="1">MADCITSNIPSADPSWHTDKHHPYYKDSHRKLQKFIREYIDAEVAPNVEQWEKQGFVPEKNFKRHASLGFLAAAVFPLPKEYLKGVKLPGGIDAEEWDEFHDAILIDEMARCGCLGTVWGINGGATVGGAPLSIYASPEQKQKYLAPLLRGEQRHCLMITEPDAGSDVAGLTTTATKSADGKHYTLSGQKKWVTQGQWASHGLIAARTGNKGAKGISVFIFPLNSPGVTRKKMENSGVSSSGSAFIDLDEVQVPADNLIGPENKGFEIVMSTFTHERLWVGITALRLGRIALEDSYKHALRRETFGAPLFSNQVIRQKIAKMTGLLEPVHFFMENLVYRSVRTSPLEFSPLAALLKVQAAHNLEKISREAQQIFGGLGYSRGGGGGRVEQISRDVRVLVVSGGSEEILMDMVAKSQRRLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR25</accession>
    <name>A0A6A6QR25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_539872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR25"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="253" mass="26513" checksum="C942763BB6A64F1C" modified="2020-06-17" version="1">MSYSDLKGKTYIITGAASGQGRTTALMLAKQGANLGLLDLQKPEDVLAEVERIGAKALAFAANVVDYAAVEAAVKATSDKFGGIDGAANMAGVIGTQGFNGKGYALDTIEDKDWDWMMSVNLTGVKNSIKAELRHIKDDGSIVNAASIAGQRGTPWNAPYGTAKWGVISLSKCAAQEYGPRGVRVNAVAPGVIDTPLAKALGSQEQIHDRLLSRTALKRIAQPEEVSKVILFLLSDAAGYITGSTINVDGGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS40</accession>
    <name>A0A6A6QS40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_511617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2494976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS40"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="50" mass="5849" checksum="D5404CFB7355FCF2" modified="2020-06-17" version="1" fragment="single">MLVEYRLPCTILRRKLKDPLEECTIQHGRRFNGLYIGPGTILPRTNRATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSX2</accession>
    <name>A0A6A6QSX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_583011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="204"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36721" checksum="B1954996DBB3AC42" modified="2020-06-17" version="1">MPSAKPNPKSRNHRVPTSVSSFTILPLTLPPLPALKSQPSTPHYLYIQPHDPKLPEPDTERSLFIANVPIDATEGAIRDLFADQLGGGRVERVVFEASVPSYAALNTNQADGTRGERRGKKRKRGVVSEDKVGVVEDAETALPRVWERGLCVSGSSAVVVFVDRASAKGAWVALRAAVKGGEEVVWRGEGGLGEKRYRNHHSLTFPPRATLQKSINAYLTAFTEAEAMRDRLRAKQRAVPDEDGFVTVVRGGRIGPARMEEAQAAKEKAEEKDKKRVAKDDFYRFQTREKKKEREMDLRRKFEEDRKKVQEMRERRGKVVVSGSFESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT73</accession>
    <name>A0A6A6QT73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_512435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2789670at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="512" mass="57894" checksum="4D7749015745BE07" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTG5</accession>
    <name>A0A6A6QTG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_461280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTG5"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2495695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="34861" checksum="61798916A2628757" modified="2020-06-17" version="1">MTSAPTVQPKFLPSRHDLGLVAVGFSGGQTKAGVDAAPMALIEAGLIQQLEEDLDFKVTYDGQVHSYTDIMPKEDPDYRGMKKPRTVSAVTRALSEQVYEHAKSGKFVLTLGGDHSIAIGTVAGTAKAARERLGKEIAVIWVDAHADINTPETSESGNIHGMPVAFLTGLATEKNEDMFGWIQDNQRINVKKLVYIGLRDIDRGEKKILKEHGIKAFSMHDIDKHGIGRVMDMALGWIGSDTPIHLSFDVDAIDPMWAPSTGTPVRGGLTLREGDFIAECVAETGSLIALDLVEVNPSLDVKGASDTVRAGCSIVRCALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTZ5</accession>
    <name>A0A6A6QTZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3431 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_527378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTZ5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025497166" description="DUF3431 domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47763" checksum="BDE973FF1730F9D3" modified="2020-06-17" version="1">MLAGPPRLLSVVSVAVVLLLGWWYLSLVHTTSATPPLKTDHSPPPKSPKKNTGFRASVDPLDFSIPLIFTPGTPKPAGSNYSRILVLPKTQKEDIFWIHAELPDIPLAVYQVDNDTAEFRVPKNKGREAMVYLTYLIDFYNDLPDTIMFFHSHRYAWHNNILMGLDTAQAIRRLSDARVARLGYMNTRCHTDPGCPDWIHMDRPVVDFDDFHKPEEKYYRKGVWDELHPGAPIPPSLSAPCCAQFAVSRERVQQVPIERFIHYRKWLLETSMDDQFSGRVFEYIWQYIFTGNAVYCPAVSSCYCDGYGICFGGEKKTQHWFEVMDERNKYYEELDGHNKEKTKAEEEGKAFEFTEEVKARMKELEAKIRSMDDEMNKLRDAAYERGKEIRNQEAERETYDDTHIWDKVEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV89</accession>
    <name>A0A6A6QV89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phenylacetate 2-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_509328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV89"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="516" mass="57889" checksum="6B6711294B58FD75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW79</accession>
    <name>A0A6A6QW79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450 oxidoreductase OrdA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_485581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2496130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="525" mass="58758" checksum="4373223DE77A90E8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWP0</accession>
    <name>A0A6A6QWP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWP0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="222" mass="24519" checksum="5CD4F7C20D866FAC" modified="2020-06-17" version="1">MDVAQVCSLSSVAGTAFLTFNLVFMSEALLLSLLPIEKLSTLSSAVEATREALHPSSMLEMSSHTILHQHLLHLINTRSISTTAAIIQQTQSLYSKRNTSHSQLIPHFGTMQIHFLKVVTPVLAFFPCQVGYIKIVSEDSDIFGTTTAYELFDVPTTISFPSRFNGVHCLVDTRGTSIFAAPAIKFESLPPIDATYCHWCQDRFFCAAGKTVFGAMMMYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXI3</accession>
    <name>A0A6A6QXI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Interferon-induced GTP-binding protein Mx2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_608235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
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            <end position="18"/>
        </location>
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            <begin position="720"/>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="808" mass="90306" checksum="1708696116D82A66" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
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            <name>heme</name>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QYK6_9PEZI</name>
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        <submittedName>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 269.34</strain>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
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        <location>
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            <end position="123"/>
        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ13"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="168" mass="18418" checksum="8C532E13FED286A6" modified="2020-06-17" version="1">MEDPDRDWKPSGRPQSTIARNFSAELDSLFKTDGDLDTLDRTVHQKKQIVSTHTQELEALEAKLRETEERLNKAKTSPPAAFSRKNSQRRTPIQGTFAEADKARAPEPSSPLSQVSNVPQAGSENALPGPMPGAMPETPLSNNSREYVMVDSHDGQANGEGESVRPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZI6</accession>
    <name>A0A6A6QZI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_580280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZI6"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="134"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2497659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="586" mass="64455" checksum="05E06F4E6EC0C552" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZJ9</accession>
    <name>A0A6A6QZJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_580486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZJ9"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24940" checksum="B44734B1A213FC3B" modified="2020-06-17" version="1">MTITELALLRLLPPTTSTTPSLLSALANAKTVMESYTHHRFHILQQVEDPTLLYILGEWDSLTQHMEGFIPSATNQALLTSLHGIVEVVSLTHYDVPLTQLPVPDAVEKKGRRGNGNGKGVVSIARHFVKAGQKGKFEEAFEANKGELQEYVAPGVCGWGWRVDREKEEEGQGEREEFVLFSPWESVDAHVGFGKTEAFERYAGFREWIDGADVKHARVLELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R059</accession>
    <name>A0A6A6R059_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_483521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R059"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="234"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="869"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130205" checksum="CB2DC56DB5CA4EA4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0F8</accession>
    <name>A0A6A6R0F8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_559723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0F8"/>
    <dbReference type="OrthoDB" id="3690497at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="639" mass="72169" checksum="7702D717FBF4B83C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1G0</accession>
    <name>A0A6A6R1G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic oxidoreductin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BU16DRAFT_524707</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1G0"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025340943" evidence="20">
        <location>
            <begin position="22"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="97"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="421"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="133" mass="14955" checksum="776FAF0CF9AD97B4" modified="2020-06-17" version="1">MEDIMVGDQREKLASPSLAFHRCHIAQIRSVIGLFGILCGSGHLVRSYGDQISVSTARMLFHISSKSPLDSCPVSRRPPRLVQELYMITETTKHSPNLDCLMSRGVVIKDRDSKKQHDIEQGPYMATSWLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R312_9PEZI</name>
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            <fullName evidence="9">Purine permease</fullName>
        </submittedName>
    </protein>
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    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000324">
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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            <end position="104"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="220"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <sequence length="579" mass="62150" checksum="2D728B33A668FD15" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R374_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2" key="1">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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            <begin position="11"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R386_9PEZI</name>
    <protein>
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    </protein>
    <gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
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    </dbReference>
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            <end position="157"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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    </protein>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
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    </dbReference>
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        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="765" mass="85291" checksum="261D1FE05B6B537A" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <name>A0A6A6R3S1_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="405" mass="44240" checksum="5AA66445113209AA" modified="2020-06-17" version="1">MKRTGASSMHAAVKGLCTVCVTPTHPIPRLASESVSKPATFQGSRRTTPRPTDWATRDRRTLVEQSQWQQREHPTSAQTVVSPQICLSANAGTYAGTERTSVSSYATLFDGEEYRETLPAAPPAPPAPQIPPRLTGLASSLATQVKRRSRKVTPLRSALVLRLAWHARQSAPGEAFRSSTASSKTGAINIRQAAANSTSPLRWRRPRSTQALTRPMNGDAFKGKAHAGTRQAHGMPFVLRWPLEGFEEWLDRKLRVPQALTVRVLAGKGLGIVELYPSPWSRRRFRFMPCGDNSPEAPNFGISRHGCGGRSYPTFGTPRRHGTIGDSKCHPPLAFAPCCTFTWKDGDEPSAAETGPAWNVSMATRELVSLTMSISPSGCDIGPNEKRDKKNSYVGKQTPNCSEQM</sequence>
</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2499488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="20043" checksum="17831F390B83319B" modified="2020-06-17" version="1">MRDAETLKREKTSSVNATQRLIGRTVELRHQVCLWARRFETLMPPPEEVQSGMADDLFPTVYRFADHVVASIFNCYWATNLVILEALRAAQYEKDYSADFESLIDNICKSVEYISGTGLLAPYYLAFPLKVVLMIGPHVKKMWIKRWLDRFVESYQVMAYEMPEGLKHVWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R4G6_9PEZI</name>
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            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2498653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016810">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
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        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
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        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4X2"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="382"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="496" mass="52050" checksum="11FB85328E672E29" modified="2020-06-17" version="1">MADTEMGDAPDVQSKVQIRLTTRHSDIELPEDPGVLLVSTNLRRYALSSLVNNLLNTAHPIPFEFLINGQFLRTTIDEFLTANGISAETTLNVEYTRALIPPLHVASFEHDDWVSDVDILSATSKAGKWGGSSSIPSGQERILSASYDGLLRVLDMSGELILVSDQPNNGGRISSLKTAKFLSPSKIVSGGLDMTVRVWNYFESPSEGRTGLTPALELYGHRLGVESLAVHAPSSRILSASSDTTINFWSSKASDAPSAPAALLPNSTAASAKRLKLSKPANLKTVAQRGPLATLAGHTAPVSSVIFAPNDATVAYSGSHDHTLRTWDLPTSTLVDTRTTSHSLMSLAALPTLNLVAAGTSARHVTLIDPRASAKTIAALTLRGHTNAVVSLAVDPESAYGLVSGSHDGTCRIWDVRSVKTTAGDAGGVGGQVGESAYRIERESAEGKKVPSSGEGVKVFGVAWEKEVGIVSAGEDKQVQINKGSGGSASSSGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5X4</accession>
    <name>A0A6A6R5X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_535529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5X4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="149" mass="16880" checksum="11971045B1E33398" modified="2020-06-17" version="1">MSSSTGTGKPMEEHLAAAAGEQLQAEDNAHALAGWMEGLALRPKEPPKPRKLKTMAKTRVVLRGARFRPREEREEKKAEEEKKEKGEKKEPKRGRYGEKKRRALKLHRRNEAQRKREEGEEGQERGEDQEGQEGKEATAVVEKGAKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R645</accession>
    <name>A0A6A6R645_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_451880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R645"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="571" mass="64609" checksum="BE9F9D08B017B690" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6J9</accession>
    <name>A0A6A6R6J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_273631</name>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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    <sequence length="307" mass="32925" checksum="358CC59E44BF5DC3" modified="2020-06-17" version="1">MTTTKPSIVLIPGAWHLPIIYSAVEALLREVGYTDTCAIQLPSLGGEPPCAERESDITLIRSTVTERLQQGKDVVVVAHSYACIPAGEAVRGLPSKIRADDDATTEGSFAQMTHQATQGIGMQTTTSTATDVNLSLGASIENPVTSPTGHVLALVFLAGLLDPIEQYAPWSRPDEPYVRLSPDVSEVKNLFYNDLDAEAQDYWYEKLAAHHSYGALTTPCTYVPWQGDFKCVYVASEDDQAVPLAVQLAICGQEGAVINVVKRKAGHSLMLSQPKTVVDIIERVVAGQEIEKGGDEGEGVEGKGTDA</sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RBE8_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
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    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="431" mass="48760" checksum="6FE876CEA87A7C00" modified="2020-06-17" version="1">MADQLPAELTQEVFRFLENFVPNERIDILDAESVEAIKNTRLQSRFWSQNGWRTFGKVLGQAPFFATKVSMAELDEFSQIPAVGERLTTLTFCGMGSRNLLFQNPELDLEDRRTKDFVACHAAQISYTTSSRPYSSSAQTLTSEFEKDLARILPRFPNLRHLRYLPAVEGHLKGYRWSDVPSDGLYIPEGTEDYRPLILDRIAKVLVHNNIRLESFSGPLKGNTNPNRDAVPASLFRFCTQSEPLARMLNTVQTLAINLRFENDNSPNHDNEASNIGHLLQSLHSARTLELACSNTDDAEPLWTQLHLAASLTELRVSFTAADSVDGHSMVAALRSLPNLRRLALGYVNLADEMEWDWVFELFRTTLNLDKLLLVEPLEFGAPSRIDWNSAGRVDEYPALNEAAGEVKVVQDRRGQLGWPPSDYLAFRNFE</sequence>
</entry>
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    <accession>A0A6A6RC84</accession>
    <name>A0A6A6RC84_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC84"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="16356" checksum="1081E915ADE0A0CD" modified="2020-06-17" version="1">MLAPTRGRALNTPALSTGANHNNEPSVVAAAGHRGVRPRRLDQAERWMPAPWLTPPSPPRPIRSTAIAQLLGPHNAAAITASRASDAAGACANHGVGNMQTDRTSGPLVSWPCRIKPATKPACEFDSSDLLLIREIHFVSFVRRWASGVDAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCE2</accession>
    <name>A0A6A6RCE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_498240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCE2"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="170"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2502538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="490" mass="53366" checksum="D30D6E3383435CC5" modified="2020-06-17" version="1">MGGGMSLLFAENGLEVSISDPSEETMDKVLKRAEEEGLGGRLKKFKDYKSLCASLSSPKLLVFSLPHGDVGDKVLEGLTPYLTSNDIILDCGNEHFANTERRQHKCRSTGIHYLGIGVSGGYQAARQGPSMCPGGDEEALRTVMPLLERVAAKDKNGRSCVGAVGKGGSGHYVKTVHNGIEHGMMSAISEAWGVMRAMGMGIEEIGNVLKKWNEEGEFRGTFLIAIGADLAHKRDEKKELVLPTVADKVVQDITGEEGTGIWSNTEAIELHVPAPTLNVAHAFRLASAYLGGREKAKKVAGGGWPPRKLEFGKGQKEAFVEDLRKATFATCLASYIQGLTDIDAANKKHGWEIDYAAVLQIWKAGCIIQADYISEELLAPVLNSGNPKSLNLLFNDRVVRDIRNSMDNLRKVVAKGVETDQVIPTLSASLEYFKIATGTNLPTSFYEAELDYFGAHMFDKKGEEGIGGPTEGKHHFEWKPARTKDGQEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCM1</accession>
    <name>A0A6A6RCM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCM1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025344038" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5577" checksum="875626849DAA357E" modified="2020-06-17" version="1">MSFATATCWGFNCILALTWPALVEAFTSNADNEACEVLCGYDTMVHEKVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDM9</accession>
    <name>A0A6A6RDM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="225" mass="23787" checksum="13CD5D9C6E5E1378" modified="2020-06-17" version="1">MESVVPACRSSQHSVFDSHSTTNPSGLQLQESYGTYRAPHSSSSSVQRCPSAQHRDCSQCAPKAHSAGGLLHSRLQLLCALSLAVPLPTLVKHAQLKIRPSRSLQPSSCPAPHHHQTLLLPPIARAAGLHRPHRLRVPPTPRSASGVLLLGAPKHRSPPGGYCTSPPGRSTSKQPTADIATTRLDPERRLDLAGGPPPFLGPSAGDLCQPSAAPTSVRDRADDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RDP9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">BU16DRAFT_448997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="230"/>
        </location>
    </feature>
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            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2502522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="47474" checksum="89FC0EAAD2002B76" modified="2020-06-17" version="1">MRFAIESWIWYTVAVGIIVARLISRSILFGSVKRLQYDDWIMGLFVLGTYTTLIVMTNIAAKSNSNLLPPGFPLQNLTSEDISDREYGSKIVIVVEQMQIAVIWANKACLLILYYRLTRMVASKENMAIKLLAVYVALAFFVMEILYFGVWCRPFHEYWAIPTYNSQCDRLTDHRITNAVFNISSDIMMLCIALPMFIRSLLPLKRKLILCCIFSLGIFVILAAILNKYYSFKSPYSTSTWISWYIREASTAILVANLPFTWTLLRKLFNLGAFDGSAPPPATYHSSRTAGGRRTQRKRDSHQAPVSKEKATLEGSQNSEVSKDSKEARSSGSRLGPSETPTTMQSDHSDLPLVPEMSSHPDSWDVEAQRATIAPPKKVHIAPSIASSGISGLSSTKRQTGGGGGGGGGRSARDRKMRAKMAEKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDR8</accession>
    <name>A0A6A6RDR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX-associated-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_475065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
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        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
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            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502711.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="73811" checksum="0AAC706D3B0EFA97" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDV1</accession>
    <name>A0A6A6RDV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_498718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="48826" checksum="90619324D6DE51CC" modified="2020-06-17" version="1">MNPAPITRFLPKRPIYRCLNFPRTPVRTPQRCRYNSTRDALTKDYNGSNADAFMKDPLRREEIERRKLIQGRNRAALGAALCMLLPIVIIQFYDLDDLSNKKKESKSTSSSNSSWFPSDRADAPASATRDFQGKPVVVTDSNEELVPTGTSYVPFFPRSIQLPTTSGSETAPSSEEYTLLGLGIRKVSFLRVQVYVVGLYVKNSSLPLLQSALIKHVNPAASALIPGEKDHLRRVLLDGESSERVWDDVLQRRGLDGIEMALRVVPTRGTDFKHLQDGWMRGLTNRTQDTQRRQQQLLAQQQQEQAKKINLPKPVDPSEFADESFGESMRAFRSLFAGRGKAAKGSVIIFTRDAEGVFRALYQSQPQDQNVRKGKKDGEFVHLGEVKDERVSRLVWELYLGGKNVSSEEARKSVVEGCINLVERPVGSVEGMVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE43</accession>
    <name>A0A6A6RE43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_554731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE43"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="480" mass="50906" checksum="01A06B63B414A7C4" modified="2020-06-17" version="1">MALNRENVEYTLRTIFRRCVQCPTNQSPSCPDCPSGQICAQTPYSCGACASTTCIQQTVDPTNTAPQKSSGPNVGAIAGGVVGGVVFLLIVVFIVYKFCLKGRRQQNQEGEWREVDAPAEKNDQNDFASRRSARASTHTVASMASSVLTRASNIIQIAYIPGVTNRSGPGSPDLLVPPVPPIPSATSPSTALTSPYSMEDQHFFLPGELRDSTYSGLTDGRSSYARTSITPSLQRSSVATTIYRNNAIVSPLPAQTIVRGKAAVVSVKSSGSSSPSDTPGYETPPIPQIEQKHLAAPMRIQMPGMGSSSSLSPSGSIRSTGTLAKPTALNIVRKAKPALVTTPSSSSTTSSTTTTRPVTAVSVAESESTVGHSRARQSGSLDSDSESDSDDHSRARRSLLREESNPRDSEITVIQDTPGINQGPFADSASPDPPQRQFSRSSMLGPSGLETITEDHSSKRTSKTSHRTQSPFSDDNEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REJ9</accession>
    <name>A0A6A6REJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_521502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REJ9"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34398" checksum="6ADAB6B52EE3188E" modified="2020-06-17" version="1">MAANKVTKSKVAKKTSQYKAAKSPARKAATGRVSSLPSREPTRRNDIRRCRIMNTPFNFKGLPAEIRNMVYGHVLEECDHMTTSKKQIRRITNTNILMVNKQLHHEAADVFAKGSVVTIRPFNRPEGVTPVSKTEENALRTFLKVEFKQLDFGTYGRYGYHGDYGYYCSKDHVVLRMGMLAGLKERLTVFVDGSTVMEPHCKRYAIVDVSDLFWVSDSAELERRKDVLEQWLECLRIMRSDTHTQWKVITSAPTTRLCSWANSQSQLQPSPTFDYYWSHLAEWNAVETAYNEGGFTIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF81</accession>
    <name>A0A6A6RF81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_30061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RF81"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2503124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40257" checksum="FA4B7E4E7F4FF8D4" modified="2020-06-17" version="1">MKMSPASRNWEYHIRCLAAAIILRGPNHAYSKINFHLLASSRLLLMLQTLSAREPNDWQERLPIRSAWLGEIKLALGEAENPKFSTDYELYRSVDSLMIEVTTVVSTMAQFDQLLAQRSTAPGLNTKGSNQILIDLYDTAEDILSRTEVRLARWNTNICEISFSSWLSLYHDMATNPISGLFWSNINEGEFRSYLDSVLTFRNMLEYHSVTMYWTIIMSLRLLLSDMLTLMVWTNVDGMPANSPQRIEDHRIKLMKYALNVLQTICYATHMENREVAPFVFATAFQLTVAVLERECKSLREAAGNHENRVMRCEGLKSLAVRYLDWAVQNKIPVTIDLDSLRKWEFASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RH18</accession>
    <name>A0A6A6RH18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_612360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RH18"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="116" mass="12845" checksum="04E58AB555CE84C1" modified="2020-06-17" version="1">MQTQPITKNWYSAFTETGLHDWLQANGVGNGPLSFAGVTTNNCILATLTDAFFQRYLVRVIRECVGAVNKKSEVEAFKEIERYYGSTVRAESMIQSSSTDRVEEAEADVADPFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RH82</accession>
    <name>A0A6A6RH82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_521480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RH82"/>
    <dbReference type="OrthoDB" id="3945172at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="125" mass="13401" checksum="1C9D60DABF141E94" modified="2020-06-17" version="1">MAAPSPSEFLTFYRRIALSPTLRRPLTTTRPLATRPFTLSTRLQIDSSAKTDKFPDDEHATSKKDRLDVQSDSAHSGKNSKATGEGGTATEQSDSQGATAKAKKEHPEAPDTVIGMQDERGGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7Q5</accession>
    <name>A0A6A6Q7Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_601197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7Q5"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF6">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="31157" checksum="24542401A2ECBE57" modified="2020-06-17" version="1">MSNPTSTPTPLTWLVTGCSSGFGLSLTRLLLSTPHIVIATSRDPSRTLDLVRLVTSAKPLNRWLALDVTSPSSTTFVADLEASGVHIDILVNNAGYSIFAPIETVKEDEIRAQMETVFFGPLRLTQAVLPGMRARKSGTIVNFSSGAALEGQPTMGVYAGAKAGLDGVAKVLAKEVAPFGIRILTVVLGTFNTNMGNAAVFGEVGLPEGYEGTMTDNFLQIMKSGTWPPNGDKEKAMKAVYEVVVGQGVGEGRETEKLLLLGSDMVARATGVREQLEHAVEVFGDVAKGCDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q826</accession>
    <name>A0A6A6Q826_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_568342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q826"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2488465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="541" mass="56484" checksum="2FBF21FFC97702CA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9F0</accession>
    <name>A0A6A6Q9F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_472855</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9F0"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2488892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="39909" checksum="9FA4D186AFC89517" modified="2020-06-17" version="1">MQAEQFLSNKSPGFPKKKCGVLGATGSVGQRFILLLALHPHFVLHAVGASERSAGKKYRDAVKWKQALPFTAQIGELVVKKCTPEEFKDCDLVFSGLDSDVAGDVEMAFLKAEFAVFSNAKNYRRDPLVPLVVPTVNLPHLDVIKHQRKQHSLQKGFLVCNSNCAVIGIVIPFAALQSKFGPVDQVSVVTMQAVSGAGYPGVSSMDIIDNVVPFISGEEDKLESEAQKILGGTNADVTGFVDQPMKISAACNRVAVLDGHTACVSLRFAKRPPPSAEEVKQAMREYVSEAQTLGCPSAPKNAIVVMEEADRPQPRLDRETDRGYAVSVGRIREDESGIFDIKFVALSHNTVIGAAGSSILNAEAAVLKGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9N2</accession>
    <name>A0A6A6Q9N2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9N2"/>
    <dbReference type="OrthoDB" id="10571752at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="236" mass="25904" checksum="B39413595C23E8E8" modified="2020-06-17" version="1">MIVTGKYVYKKYKKRKQAKEDLLAADSAHHDEMVNAIQDPSLPTLMTGDASNPTPASYQAHPPPYSDVEQAMFAQTQPQYAPFSPPHPPPSPLSPSTLSPSSPSPYLHQQQSLAPTEIAVRGRWVWQPDTPQIPTPVATDSSYMVSLPGQPLKHQAVELEHERAPAELAIGKTFAFEKEVENGPVELPADLPSSDDSSDGEDRSTTTRPDMEKRAQSDPPYAMSSKLDQYGPLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9N6</accession>
    <name>A0A6A6Q9N6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_520144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2489035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9N6"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30997" checksum="DE5FD758D1C2A41D" modified="2020-06-17" version="1">MAPVIHCIRHGQGFHNLGAGFYSLHDPHLTPLGISQCETLQATSFPDQSNISLITASPLSRALHTAFLTFSPALTSGRKCPPQILALPDAQETSDDPCDIGSDPSVLRGIVAENNWPVDLSLVKDGWNVKTLENRYSPHSSAIAARARDARVLLRQKIRELVRKGDTDAEVVLVTHGGYLHFFTDDWEDSYQYPGTGWHNCETRSYSFEEDVMADADGEARLTETTESRRKRGKTYPMYSREKQPELFELGMQRWESQGLQRPDKLRKVPDMSVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA04</accession>
    <name>A0A6A6QA04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_622749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA04"/>
    <dbReference type="OrthoDB" id="3692147at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51286" checksum="0B58D770F98849F9" modified="2020-06-17" version="1">MSSKPETSAAEEHASNFLQVALRNACRLPLRLLALKPHRTWQSITRPGEPNSRQASSQVPAATIHRDKRTYTDRKQQAAALHNATEASIHQLPTELLLMTRAYLSPASNMAMHQTCQKMMDIFTLFAGTFPLDEFNPESVWLETPQSARVWCNACERRHASNLFSATQRTRPPLERRCVGMNEAIRICEHQWLTFSQIAKSVHGEWMIQCEDATHNFTHWPDHWRPTFKICSREHEAQMKSWIPIITIPQGYTVSNHRLAAVLSESTEPICMHLSVYDPIIFNLVSKLIHARDTGQLKWYRSEGTPCVHDPPVGSITSTACCQWHVSTNENDFLPSQGAWISDWWKMDCRRQYVWGCPCEIKVFLRRLPGSDVEEVIMEVCRKWTHKSMDQDWMDMIGYGPGGVIGRPRSGMRGFHAVPGSAKPVQVSWAELMQREGLDQEGLDQEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAY5</accession>
    <name>A0A6A6QAY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAY5"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="517" mass="58501" checksum="624E21882375F3CC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB41</accession>
    <name>A0A6A6QB41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine palmitoyltransferas-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_161237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB41"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="253"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="679" mass="74463" checksum="8B06940EC05EFE81" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBJ2</accession>
    <name>A0A6A6QBJ2_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_472225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2489511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBJ2"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="124"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="53363" checksum="B771C680D707A4AD" modified="2020-06-17" version="1">MDFKPLGSYPKTGINVLIVGQGLAGLTAALECVRKGHDVTLLERSPTYNSAGDMFFMGLSATRFLEHWPKLMEEYNSFSLSNAWLELRTHTGAVLGPPMPVTKIQAPGLNAGVPPGKFQMRPLIYRMLVDEAERIGVKTVYNARVVDYFEDENSAGAVTEDGTRYTADVVIAADGVGSKSQKIVGGQVRAQPSGRAMWRAAFPREVLDEHPEVKDFIPLKDGQPVVRTWVGPSTYAMTATQEDLIIWTMNHDVTGSESESWNDTIEAEEVVKEMDKLIGPLRWAPLLRELVKCTPSKSIVNFDLLWRDPQPTWSSTTGRVVQIGDAAHSYLPASASGGTQAIEDAVHLASCLQIGGSKENVPQSVDVHCYLRFIRNACAQKMGFANAELMQNTKLDEAKIDPQKARPRLAKWVYFHDPEAYAYENYEKAVSGIKQGIPQDENLEIEPNFPKGYRYDAWSIEDIQEDKKNGKPLNLGAGDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBJ5</accession>
    <name>A0A6A6QBJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBJ5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="195" mass="21038" checksum="41597380536306FF" modified="2020-06-17" version="1">MSSQQAAPPVATRFESSIGNESKVALFELGSTSPSRPAPVALDDRQQSQLNTMGYDHLRYPAPHFSNPWRSGPAAPSSQMYPASGLEKFEGVSQQHVQRPTSLLLPFHNLPVTAPPLGSGISLSDGTFGSQNLLHASQDLLNPARTYSGNSSASPNAASYAPTSAPKYLMDYSNNSRKPYAYQQDSLRQLLRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBV5</accession>
    <name>A0A6A6QBV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_586057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBV5"/>
    <dbReference type="OrthoDB" id="10315494at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="26385" checksum="AAAC1D04B2B88661" modified="2020-06-17" version="1">MPCRINMDRNPHHRHPVHWPTHNAHRGFSLYKCEVFCDWCPAGGKKGFHTSSALWRHVTMAHPTVPNLPGPPVEVWVFPEIIDCHPNSTWKPPEMPVPYPPVDVLGWPNRASPVNLAAYADIFWGAVGELAIGNGEGMQILRDNEDKPAEYQDVVEMQIYLRVGKGREGYEKSIEIDGNKMELLGGMARIFWEVVWKCDKNFEKGYSLVQAAWIREQDRYRNELRRLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC19</accession>
    <name>A0A6A6QC19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_495373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC19"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="673" mass="80987" checksum="7B528309B4EA9195" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC84</accession>
    <name>A0A6A6QC84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_553330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2489067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="39137" checksum="7C1A1EE441996E10" modified="2020-06-17" version="1">MSDLVRDSRLRTIFPPDARQGEVPTLTAHVFEESGHHLQERLIERKEVWKRERFVARGAYGSVWLERCVKGSRVDETRAVKQIMRSPQQASGSKNVLDYDRELESFAKLSHQNYNRCFVQSFGWYEWENALLIAMEYLPLGDLQDHLSESSQLFEPEGQQVTSQLLEGLSFMHQNGYMHRDLKPKNILIKSKPPQPWWVKIGDFGISRRADTEFSATTAIQGTLGFLAPELHGLVGLSSDRGRHILGASDMWALGETVFRLLTNAVSFPTLRDLISYARGETPFPTKPLLDCGISEAGVSFVCELLIVDPGKRATGDSGQEHDWIVSQRASRDGSRPPSFLFSGLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC97</accession>
    <name>A0A6A6QC97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_544402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC97"/>
    <dbReference type="OrthoDB" id="4456803at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="28380" checksum="334BC23AF6CE2C1B" modified="2020-06-17" version="1">MSGDVSDDASMEGAGYPLFVTANLPVEVINSFLFRAMEERWENNDPSSERVGNPWVLIQTRDQESFAEPTIPPVEPSESGFIGATIEELSNFVETTFGDDGRGHYIQNDRFGVLDARTREDNTLEFVVKEGLSPLDLAQLRIIDGNYTRHDEAMVRYSERKATQEDLAVLVHQIRDIPQHSSDQQPLETEVSEEDITTFRKLFIKQNVGSNMWETLNDEWVRVRLDVATAGQNTAGIYQIGPLAFLQLPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCN2</accession>
    <name>A0A6A6QCN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCN2"/>
    <dbReference type="OrthoDB" id="10580918at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="27580" checksum="7A5E1FA37DFD3B62" modified="2020-06-17" version="1">MPAKTPQRSAARKTAKNKPKQARKAPPRVPSSSNAAPFPGYRVPTTRQQSRSALDEASDNENNIVPPAQRAPPHPYMEDISVPMPDISKLDLQSTQSPGHEERVPGAESTPRGLAGMNPPPRPPVSTIIPPPPCPHHCPPSTTAAIFRHAPSNPALAKEIFSNLDRVLAREAQEPVKRFLVDIAIDMVIALENDRTIEIERQGMEPAEVDGRIAWAKWAVRAVHEGLFHAWSVECGGVVRQVEGRRREGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDR1</accession>
    <name>A0A6A6QDR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_420858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="150" mass="17096" checksum="EBE33963F8B1ADBD" modified="2020-06-17" version="1" fragment="single">GSYTDRRYFGVLMVPVAEHSLTDFLASSEQHVRHRITLGTFFGCLASALHYLHQNQIRHRDIKPDNILVKGAGVYLTDFGISLDWQQLSRSTTDEASGLTYNYCAPEVLDPDQKRNSRTDIWSLGCVFMEILVVKRGLRIEDLKTTFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDV9</accession>
    <name>A0A6A6QDV9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_596099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10684145at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
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            <begin position="310"/>
            <end position="407"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="892"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1172"/>
        </location>
    </feature>
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        </location>
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            <end position="377"/>
        </location>
    </feature>
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            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="618"/>
        </location>
    </feature>
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            <end position="857"/>
        </location>
    </feature>
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            <end position="934"/>
        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="1505"/>
        </location>
    </feature>
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        <location>
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            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1607" mass="175257" checksum="BDEA1F8590224BDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDX2</accession>
    <name>A0A6A6QDX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_622318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="611" mass="68376" checksum="643B4DE2CA0EBD64" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEJ8</accession>
    <name>A0A6A6QEJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_543855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
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</entry>
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        <source>
            <dbReference type="EMBL" id="KAF2490197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="90712" checksum="EA368FFF5F1466EE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFR3</accession>
    <name>A0A6A6QFR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_585677</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFR3"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="202"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="407"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2490463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="578" mass="63020" checksum="9498C2950D444F28" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFV1</accession>
    <name>A0A6A6QFV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tom7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_530862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFV1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2490367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="53" mass="6072" checksum="6E0F70C7613C6400" modified="2020-06-17" version="1">MVSLSEESKERIARIIDVSRVAIHYGYLPLILYLGYTHSEPRPSIIRLFSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGC7</accession>
    <name>A0A6A6QGC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="27"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="370" mass="40870" checksum="F0D830333FD66B16" modified="2020-06-17" version="1">MGALQTIIIWVGCYFIVPYLTFLSPLARTLTSVLAPYVVPKLIDFVKSILYPNSSIPIRPVPAPTKRALNLLFASASLALLLSLPAFAPENIFVATQSRLQIDTDVLFKRLEVLRPLTPTDITLRAKFVNTESRLAYLAFGPDTVAHCTVCGADDAWGYFAYHLPKLLWPHLLHAVVLGAATSDVFAGLEGARWRKQGWIAALAIVVVEVWYTATYDMTRNKKVKRMEDLANVFWRVRTLRLLAVAGLDGLLGLALWLTSTNRWLARPPPVAVRVQAATKNVEETLMKMRALGVLRNAVVRDKVLRGEVEQYWRQEGDVMGELVQDPEVAVVINGVVEEINMDKVQTDAGAMADGIMGGLVPGSGHVKEE</sequence>
</entry>
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    <accession>A0A6A6QGQ6</accession>
    <name>A0A6A6QGQ6_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_565294</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10471045at2759"/>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIL4</accession>
    <name>A0A6A6QIL4_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_551947</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10250282at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="44477" checksum="3E2117702994AD9E" modified="2020-06-17" version="1">MPQKLKLAVAQARTLSSTVDTLHALEETTRSASQSGVHLVLFPEAYLGGYPRTCSFGASVGARDPIGREQFLQYFHAAVDLGDTPVGAGDDWVDKKLPVAKDTKYRGDGTREELERIARETGVFIVTGLVEKAGGSLYCGVVYVCPRYGVLGKRRKVMPTGSERLIWAQGSPSTLRAVTTTIQGVKLTLAAAICWENYMPLLRHSLYSQNVNLYLAPTADARDTWLPLMQTVGCESRAFVLSANQCVKRKHLPPWVQGTTATPHKNEPPRSTEVLPSHRRRRSTVTFTEDKHEICWPIVEKDAEEQDDSVSPKENASPTGSISSKSYGASTDDEEFLCRGGSCIVSPLGEVLAGPLWEVTDGKLLVVEADFEDCERGRLDLDVAGSYSRNDAFKLHVEGLDLNPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIS2</accession>
    <name>A0A6A6QIS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIS2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="277" mass="28976" checksum="9AB2A4AEE1EE57D6" modified="2020-06-17" version="1">MAVLKHSPSSHVGPNKPISNTPTTTTVSSSARSLSSIQLPRGSGALRGARGRGAASAGRGRGNAGAGRGRGDAGVGRGGGNAGAGRGGGDAGAGRGVARARGGYSARGVAEGCPYTGVDSAPMCIHAHSYGKREKDWMLPEFEMRWSALQLQRERMEKKKIAAATVQARHTAQEHAEKQSGRIPTPGTAPSTALQASIARSSFSTSVAMQTSKDVINAEKRRAEREAEERAKQEAEKETTEEKDEEEGVEEEEKAEEKEVKGKGKASQSSIVPPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIY6</accession>
    <name>A0A6A6QIY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_514917</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIY6"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="475"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="792"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2492182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="965" mass="106109" checksum="BE2A057F7F3D0D48" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJB2</accession>
    <name>A0A6A6QJB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_529549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJB2"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="355" mass="38091" checksum="E2C744BB60804B7F" modified="2020-06-17" version="1">MMAETNITVIGAGVLGLTSALVLSKHANVKITVVAKHMPGDYDIEYASPWAGANYLPVGEPGTALCRFERDTWADLDRLAKNVPEAGIHHQPTVLYKRSKDASSVMSQKDPWFKNTVPDFRVIPSSECPAGCEYGTTFTSVCINTAIYLPWLLGQCVKNGVVFKRSILSHISDAAALHHSGTPASITINCTGLSAGKLGGVMDPTVFPGRGQIVLVRNEPGVMGGLSGTDDAADEITYIMQRAVGGGTILGGCLQKDVWESQPDPNLAVRIMKRCVGLYPKLTDGKGIEALSVIRHGVGLRPMRTDGPRVEKEKIEGSWVVHCYGHAGQGYQSSYGSVAEVERLVESIVSEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJG1</accession>
    <name>A0A6A6QJG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_574462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJG1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="317" mass="35026" checksum="2BBF006404760489" modified="2020-06-17" version="1">MAYIEKVAIIGAGGRVGGAFAKELLRSGKHTVTAMTRKGSKSVLPEGVQVAEVDYDDNSALTSTLKGQQFLIITLSVTAPGDLHGRIVKAAGEAGVPYVMPNMYGSDIQNPAIMNESLNGKMYKERFADFEGVDTSWVALVCGFWYEWSLALKKPFFGFDIEDRSVTFYDDGKTRIDVSTWDQCGRAIAALLSLPESGASPCVADWKNKPLYINSFKVSQRDMLDSLHRVLGTTDENWTIDFEPTDQRVKRGLEDWKKGNRLGFATASYARVMYPNGDGDFGSKWGTSNELLGLPKEDLDEATKRVVKMVENGWSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK96</accession>
    <name>A0A6A6QK96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_592160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK96"/>
    <dbReference type="OrthoDB" id="4161727at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="82404" checksum="18A8597DF84A8989" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKG2</accession>
    <name>A0A6A6QKG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_574467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKG2"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000922">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="28814" checksum="30376236178B810A" modified="2020-06-17" version="1">MPSQDVILVTGANTGLGFQIIRALYSSDESYTILLGGRSLAKAEEAIDVAVKEFPSSRSKLFPIQVDIEDDDSITTAFTEVQSKYGRLDALVNNAGAQLDQEVKAGHMTVRQMWNASWNVNTVGTHIMTSTFMELLVQSPNPRLLFITSGTSTLAGSENLAIFVNKSPAKGWPKDEFSIPAYRSSKTGMNMMMRDWYRVLKEDGVKVWCISPGYLATGLGGSQEANKKRGAGDPAVAGDFIKAVLEGARDSDVGKVILRDGVQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKU3</accession>
    <name>A0A6A6QKU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_490853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="23869" checksum="30B9CA31D4E7D95C" modified="2020-06-17" version="1">MTTPLPKSYGLLLFPGFQALDAFGPLDVLNILSVTHPLSLSIIASTLSPVPTNNPVNGKLSPNFGQSVVPTHTFADPPADLEVLIVPGGMGLRNPAVVEELAQFLKGAYPKLRYVLTVCTGSVPLAASGVLERRKATTNKKAWVWATSPYANVDWVHKARWVVDGNVWTGSGVSAGIDLVLAFVEEVYGAEKAKELAIGIEYDRHEDPSYDPFADIWKITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMA4</accession>
    <name>A0A6A6QMA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_563665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMA4"/>
    <dbReference type="OrthoDB" id="3934814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="293" mass="32595" checksum="B866C415D7A3C78D" modified="2020-06-17" version="1">MTKGRKRRSDGIASLTVNSSLKSLTEFDVDTDDASPQSHRRSKHADYANPPSSTQDTHQPVEYYKPTITSKQKPVQPSKQAQDPKPKDDEIASFKRKIESDRKDLEALLKTRMADALAKEEKHRNDITAQVLKIFQEASKAQSDTDKPKSHAAAAGGKPAADFFANLRSAAVIVQRSHDMLSDYDDMALRIENAVPEADKALPETLRGEEARTKRVLGIGYKIAMKKMEAALSMEGDAEGDDEEEMDGDAWKVVKENFQKVYAQKVPDVAGTVRYAERGVMRMAKGLPWEKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMH9</accession>
    <name>A0A6A6QMH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_528628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2493319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="394" mass="42858" checksum="C93E722B404A6DCD" modified="2020-06-17" version="1">MAHSNLSSPVSSPSASIVATIFYKSATPQHAHAHADSTSHSPRDALPPTTLHHLTDGAIPTENLSSYPLEPPTPGPSPLDHLYGSYISQSCLTDFLATLGKLMPGFQENSVQTRSLDAPAPGSKGCRVMEITFALPPSSFLTLDALRNDEVVSRFEREWNVEAVFQYNSVYRRHKRLAVFDMDSTLIAQEVIDEIARELGVEDQVSAITAAAMNGELDFEASLRKRCALLKGVPSTVWETLKPRITLNCRSGELVRALKRLGYKTVVLSGGFTPMTGWLAGSLGLDYFYANNLVVSEDGKTLTGELTGEIVHAEKKRQHVLDIAMKEGVLLDQVLVVGDGANDLPMMSVAGLGVAFNAKARVQMEAPARLNSQSLLDILYLLGISKEEQEVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNB6</accession>
    <name>A0A6A6QNB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_490357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNB6"/>
    <dbReference type="OrthoDB" id="2688021at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="16121" checksum="424B5ACCBA25B051" modified="2020-06-17" version="1" fragment="single">MTYIDLGSRVSTPSTENLRDPLSSSLLPDSDSKLPQFDIALGTRRLCFIGLAFSYLLSLGLIIGGSWLLGTKGGESDDPIWITIDALNSSAVIETLTLIFNASVTVITECLGYIHATSLRWALYHEGRLHHNSNIRLLTSSRNSTPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNE2</accession>
    <name>A0A6A6QNE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNE2"/>
    <dbReference type="OrthoDB" id="10401161at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="180" mass="20544" checksum="A6CA9E85BBA3BC25" modified="2020-06-17" version="1">MSSREFSQRNGKDPAKDKQRRSSQDKGKMPSKSRADEVLRQPEPAKKLPEGHPEWLKPTPYDFSGGPTPKDKRLHGEGYGEILSGVAARFEKESAEIRADASADTTTTPDGKRPRSESPRRIPEQWWRCCRCDELHAYDTAGVCYNHREDDYHLRCEECAGTSWRNPETLTPLLKQGKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP89</accession>
    <name>A0A6A6QP89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_573339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP89"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="429"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="637"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="802" mass="87500" checksum="6B63FD8F466006E0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ92</accession>
    <name>A0A6A6QQ92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_70931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ92"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF51">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57323" checksum="130BD0EF535F5FB0" modified="2020-06-17" version="1">MGPTRPSSFDNLVSLTKRVFHRSLYFGDDRSESSLALDRGHSYKDREFDALKWGPILSIPDEAALEVALAYRRRLYPELEDTDEKFPIAEPSDITAIVKLHAEGFNNRAFIIRYNDGWDVCVRIPACGWGDNWSEMHAKNFLSQACTVRYIRENSQMRIPDMLHVNNTLKNAMKAPYMIMTAVDGRDASHVWFEDDGLTPAELEAKRQHILKTLAEGVSALRHLKFDKMGTLHFPGGFPISLEKRISTPYVGESYNRNFGWLPDKTGTHKHDAITPPYATSQEWLRYRLDQWWKETCAKDKKGASAQKHHEHKGIYMLFAMMFDYFPFAKADPSSPEPFVLAPPDFDWQNTLVADDGTVTAFIDWDRAETLPIYLGWPCYPNFLSADWRVMYEWPAKNVMSPSHLASYREDYARYMKEACGTSSDAWRYTRKSHFFSALEFAVGDAKLMEEVLFKILELLVPRTRKDEHILRLGAEGYVEAEEEWLRAKFKELFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQS0</accession>
    <name>A0A6A6QQS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Snare complex subunit protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_463069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQS0"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10797" checksum="CC7A4CCBAC24B851" modified="2020-06-17" version="1">MSDAYERERQNNSRLDDLASKVTALRGVTIDIYDNARDQGVIDSANDNFSSFTTTLKGSATRLGRMAQSGNKVAIFKLAGMIIVAVVVLYWIWSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRA8</accession>
    <name>A0A6A6QRA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRA8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
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            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
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        </location>
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            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="443" mass="49268" checksum="F4293BAA77777C50" modified="2020-06-17" version="1">MAGGNEEVAREAVPQPEGVSPQAPSPSGPLPTPIVPKPHDPIDQSSAVEPEKPLQDSPDVQAKADQADATPHARASSDATPSSPPRVVAPPPVMSQHASAHFASSSIDSSSALPSQNDDRPDEPPEYQEEYDTADSDLGDERASLTETINSQNYQYVYENGRRYHGFDNAAYLLPNDEREQERLEGQHQMWIMALGGKLHLAPLPQNIGNVLDIASGTGNWAMDFADEFPSAKVIGTDLSPIQPNFRSVPPNCSFIVEDSEGEWIWEERFDYIHSRTLGSTWRDWPGYFQKAFDFLNPGGYLELHEFTFPFGCDDGTATAESPMVQWSMYCNQAAAKAGVDMEISARMEPLLREAGFVEITKTRLRLPFTGWSEDPREREYGEHYGKIFDWGVTVGMFTRRLGWSRERAEVFLMEARKDAANIGVHAYIPLYIYTARKPLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRX0</accession>
    <name>A0A6A6QRX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_527035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRX0"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="222"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="738" mass="83707" checksum="8B9E88A334458742" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSD6</accession>
    <name>A0A6A6QSD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_509638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RidA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="135" mass="14494" checksum="5C995B367D16C484" modified="2020-06-17" version="1">MASKQVVSTTKAPAPLPQFSQAIKYNGMVYCSGSIGVNPATKKLAEGGIQSETRQAIQNLAAVLEEAGSGLANIVKVNIFLTTMDHFKSMNEVYDEFFGTIDPKPCRTCVAVYQLPFGAVVELECTAFLSPEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSS4</accession>
    <name>A0A6A6QSS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_393239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSS4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="13508" checksum="6368367D262F2501" modified="2020-06-17" version="1">MWSVLVSSHIVHLSVRRSELACHGLEVAGYAMCWSVVVLRNALYGYSSLLSSISVDSFRGLLRFDVDTWGEDSISAYGRKGGCGCVQPYQGARHVRDQIFCQTGTTRYGRYWDMCLSVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT90</accession>
    <name>A0A6A6QT90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mo25-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_550370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT90"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="583" mass="66082" checksum="5F1922FE0D6DABAF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTH7</accession>
    <name>A0A6A6QTH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_528356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTH7"/>
    <dbReference type="OrthoDB" id="2999773at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17356" checksum="53B989BD9697A55B" modified="2020-06-17" version="1">MPHPVHVLIFPGPGNRVPAHWALFVPSTPSSRTGKVIEVVGTPYTGYGLQFKRNYSIDTETRRHQLLQIGEVDAEHVEDMDGAGETEKVMLDIDARDALEREAKKVTAPGVGKQPIVMFEYENCQSWLKEYVAWLVKRKMLGEEAIGVLAEAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTP7</accession>
    <name>A0A6A6QTP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_487093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTP7"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="38793" checksum="E7D355C7AA4185D6" modified="2020-06-17" version="1">MLEFRTQGYNGYSVKYSPFFDSRIAVASSANFGLVGNGRLYILGLTANGIVAEKWFDTQDSLFDTAWSESHENQILTASGDGSIKLFDISLNQFPIQSWTEHAREVFSVHWNLVAKDTFLSSSWDGTIKIWNPTRAESLVTLPTHSCTYSAQFSPHNPSLLSAVSSDSHLRVFDLRTPASASNHLTLSVPIHTPPKARMGVAPPVGIPPSEALTHDWNKYRDSVVATAGVDRCVRTFDIRAPGAGPVAVLPGHEYAVRKVSWSPHLSDILLSASYDMTCRVWTDGSAMGVGQQGAQGQQDPMVFGNGRELGRMGRHTEFATGVDWCLFGAEGWCASVGWDERVLVWDVRAIMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTZ6</accession>
    <name>A0A6A6QTZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_487300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTZ6"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="298" mass="32622" checksum="86E2EA5654FAC6B3" modified="2020-06-17" version="1">MASKLAPLVFRRAPRVFRQFQTPQWRSFTAKTPSRSDSLQVHRDSSDNNPSIPFKFTAQNEEIIKEILSRYPSQYKKAAVMPLLDLGQRQHGFTSISVMNEVARLLEMPPMRVYEVATFYTMYNRTPVGRFHVQCCTTTPCMLRDSDSIMKAIGDHLGIHHGETTKDGLFTFTEVECLGACANAPMVQINDDYYEDLTYDTTVSLLKALQHAAQATGAQPGEAGLGGEAGKGAVTGDDRNVKSGSEINKQGRAYEAGGVKVPTPGPLSGRKSCEPAKGLTSLTGEPWGNETLRTDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU77</accession>
    <name>A0A6A6QU77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_460886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU77"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058997">
        <property type="entry name" value="YycE-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058998">
        <property type="entry name" value="YycE-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22659">
        <property type="entry name" value="YycE-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22658">
        <property type="entry name" value="YycE-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="144" mass="15792" checksum="648D93DB8EADF473" modified="2020-06-17" version="1">MPPSSVSISSPAPPISKSHLRIARPTNDISAILPFYTEGLGFTILSSFTAHAGFDGVMLGHPGAPYHLEITTKDGHDAGRAPTQDNLLVFYIPDETEWKEAVTRMKKAGFGAVTSFNPYWDVQGKTFEDPDGWRMVLQNAAWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUN3</accession>
    <name>A0A6A6QUN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zf-ZPR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_459604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUN3"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="41"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2495906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="515" mass="56654" checksum="90B4C9031BF049A8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUN9</accession>
    <name>A0A6A6QUN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_357935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUN9"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2495834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="24023" checksum="B1D45E91A2C7A1B0" modified="2020-06-17" version="1">MASANFRDSMNSLGWSRRDPDIPVNTSSQSTPILNRLQSLNPFGSGGYVRLPTAGEGPGAPLPAPTRREEEEGWFALSRWDRLLVFGGLNLAAAAMFATCFALMFTPLFIVKPRKFAILWTMGSLLFLASWAVMMGPLQYMQHLISGPRLPFTAAYFGSIALTLYFSLGLHSTILTVVAAIAQLVALLWYLVSYFPMGSTGLRFAARFGGNRVAAWMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUT8</accession>
    <name>A0A6A6QUT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_437140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUT8"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="81" mass="8931" checksum="E80B86633D9ECAA7" modified="2020-06-17" version="1" fragment="single">MSATAPPISPTRFAAALKDLPLSSLHGKAAELRNSIIHLQHSNKELQPFATEGDEVCKEAIAENEEVMGRMEHRILLLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV47</accession>
    <name>A0A6A6QV47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_373629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV47"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11728" checksum="B564BA10C93E2FA2" modified="2020-06-17" version="1">MCSHAETTRDAPNEPRTPTTNPQMPSRLLQLPGELRNMIYTHLLSSTWLTFGGLLLGHRHSYTGVATKCAPNPLSILRTCRQIDLEASSLCLGHVLFNFEGLEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW18</accession>
    <name>A0A6A6QW18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_460559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW18"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000042">
        <property type="entry name" value="PAP2 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="411" mass="44891" checksum="8F65F6EE87358D54" modified="2020-06-17" version="1">MRTMDSILPSKRIIASYVFDWIVIIAIAGVGGGFNSISPNHRPFSLLDLSISLPYVHKEKIPTWLLIVVGLVIPAIIVFLVCLIFVPGRAVSRGTPKALIWRRKFWEWNTGWMGLALSLATAFMITEGMKNLFGKPRPDLLSRCNPKVSQVSADRLGGDGMDLSPLWVLVSSSICQQTDKSILDDGFRSFPSGHSSFSWAGLLYLTLFLCSKFAIAIPFLPPRPYSQDPTYTNLSASKTALPGYHSRGSTHDSATSSSKKPQSEDTLPPQTLAHSQHIVPIRNQAAAPPVYVLVLALIPICAAIYISSTRFSDFRHHGFDILFGSAIGIICAYFSFRWYHLPIRQGAGWSWGARSRDRAWFIGVGRESYVGTEGWAAESAGVNAAGEQHAVLGGGLDGAKDVEAPRGEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWW3</accession>
    <name>A0A6A6QWW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_429875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWW3"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="253" mass="29439" checksum="020909C69B2D81B0" modified="2020-06-17" version="1" fragment="single">MGRAEVGSTKHLANKMKSKGLQRLRWYCQVCEKQCRDANGFKCHVQSESHVRQMHVVGEDPKKYIEQFSREFQHDFIQLLRTSHGEKAVNINHFYQSYIGNKEHTHMNATKWPSLTEFAKYLGREGICNVSEDEKGALMVAWRDVSPAAVKRREQLREMELADAETERHEERMMKRMLERARMEAEEKKEREARAREEAEARGEVKEEAPKVEMPAGPVKLNFAMKKTLGQPGKMGLGQMKSKSIFKRVREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX25</accession>
    <name>A0A6A6QX25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_341033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX25"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="41186" checksum="6D94A7326128D784" modified="2020-06-17" version="1">MSTVPGAIAPPPGVTPHFHGPMNDKQKQVATTASVTMALSTLFLVLRLYTRGVIVKSFGSDDYAAIIAWAFAITFASLSFPAIHSGFGQHFWNIPVTDLHPFLKLIGTIAILYVWATTLPKVSLLLLYHRLTPDKTFRLAIYVLLFIILAFTLSHTIIVAAGCSPLDSSKSGCLNTLSFAAGVINIICYGFVMILPLPLVWSLQLPRRQKIGLGLLFAGGSLVIIASIIRVRLAKALQGKRDVSFAEGDIGIWSLVEINVGVICNCLVVMKPFFRRHLGNILGSSGADSENSPFSFNIGSVFSRFNKKQREPRSYRLASLDRASRPGDAGLQMPQRAQRSITVSHTYEVSGNRGEFDTESTEDMMKSVGDGRAAKDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXY2</accession>
    <name>A0A6A6QXY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_571909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2496972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="1113"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1235"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1206"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2496972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1438" mass="164593" checksum="910C4ABBBC3E0BD2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXZ9</accession>
    <name>A0A6A6QXZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_525030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141830" checksum="9589B0E42A578740" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYC0</accession>
    <name>A0A6A6QYC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_548632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <end position="42"/>
        </location>
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    </feature>
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            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="571" mass="62706" checksum="039F278F70818F62" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYE1</accession>
    <name>A0A6A6QYE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_366320</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025530696" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="23262" checksum="D4C452908107C125" modified="2020-06-17" version="1">MHLTLRKTVLFYLTSLISPSTALQPRQAITTPAAEFSSAAAQLLSLYLPTSVQSAIASAAAAASITGDPSSVVEAAFTASATPAWFSALPTQYHSNVQALESAIEKLRGQASTGVPGAPRVIVTTVQGGSTVLTVTGGATETGDLSASRTGVVSSAESAASSALSSGLSSASSVASSARSSASSVAAEASASLSSVLSSLSASVAAASSTSTSSGFAAPTRVPMAAMGVLGMLGAVMAL</sequence>
</entry>
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    <name>A0A6A6QYG4_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">BU16DRAFT_315584</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FUCOSE-SPECIFIC LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2497495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="28560" checksum="22C872FE454AEEF0" modified="2020-06-17" version="1">MPPDSSSFTALNVPAHQVPDWMGSFTLVAPPNTDLWRKPPSRDTSTAPILYTALRSPFIAAEVTVSADWELEWDQGGLVIFAGAPPGRIGAQTAAAAAAIAAANTAPPSTPAAAAPPVVVAPPVVAHDDPPPAYVTPAPASKWVKVGLEFCNNACHATSVCATSDGADWALTSLPPHHARRLDLRVKIERIGYALWVWYEDEVSGWKKLREVTWFFWGVEDKAVRVGVYASRPANFGATHYERRHGGPSVTQRNLCVDFEGLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYR2</accession>
    <name>A0A6A6QYR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_560090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYR2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="210"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="5">
        <location>
            <begin position="467"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="638"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137824" checksum="5079396A5BAED735" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZD4</accession>
    <name>A0A6A6QZD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_457164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZD4"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2497838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="333" mass="35841" checksum="669A6756929AF828" modified="2020-06-17" version="1">MDPYDMEGGAINVRFINADSTRANFLIQNFDLATANSLRRVMLAEVPTIAIDVVEVLDNTSVLADEFICHRLGLIPLNSTNVDDLLASRDCDCDGYCEQCSVVLTLDAKCTGNDVMKVYARDLVVSDGRPNEEIGLPVITDPDGFGSIIVKLRKGQSIKMKCVAKKGIAKEHAKWAPSAAIGFEYDPNNKLRHLDYWFEEDPKKEWPVNEHNANIDGVPQEGEPFDYDAVPTRFFFDVETVGGLEPDQIVLQGIKVLQRKLAGIIGDLTGVDESNGVDGFGGGQSPQMNGAQGYGAPDQGFTTPYGNTSAWGGGGGATPYGATPYGGGGGNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZS9</accession>
    <name>A0A6A6QZS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_330595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZS9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="15163" checksum="E34896E19BDCE753" modified="2020-06-17" version="1">MSAARMKTFLQGLLCTCTVCIRHMHPMRVLVTAFQPELNGLWRALAAEDQVGRRSYWSLQAFTGQRGSSTSGYGGSASGARAYSTGLFLAHALGLRPFSSIAASRGRRHSTGQRLFPRMIVQLAARHGSIGHYRAPIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0A7</accession>
    <name>A0A6A6R0A7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_548835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0A7"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2497792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="421" mass="46460" checksum="115E9DA28CBE2F59" modified="2020-06-17" version="1">MALRNPLLQLSRRAPTQFSSQFPPIASAFAPQRRWNADVAPPAAQNATGSKGPTAIVFMNMGGPSTVDEVKSFLSNLFADADLIPLGRLQNYIGPYIANRRTPKIQKQYAEIGGGSPIRKWSEHQAAEMCKILDKSSPDTAPHKPYVAFRYAAPLTEEMYQQLIADGFGAGKGGRAVAFTQYPQYSCSTTGSSLNELWKWRNRLEGKRATGEVEPEGAIKWSVIDRWPVHSGLVEAFATNIEKTLATYPREKRDKVILLFSAHSLPMTVVNRGDPYPAEVAATVYAVMQRLGMKHQYRLVWQSQVGPQPWLGAQTSNTVESLIKKGQTDMILIPIAFTSDHIETLYELDKEIIGEAGQEGIKRAESLNGNPIFIQALADIAKDHLAAGQACSLQMGLRCPGCVSERCLEQKKFFAGQQKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R380</accession>
    <name>A0A6A6R380_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arabinanase/levansucrase/invertase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_304005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R380"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38193" checksum="8A810F5101962DB2" modified="2020-06-17" version="1">MDSLSEVVALSSFLTVAFRDSPNSPLSLVSSGPKAAKEQQICDSPPACFNYIFTTFGGENGKDERTLDVYTSADGIHFAPYVMGAYVPENSLLRDPSIILHDDGWYYVVHTTSWNGDDFALIRSKDLKTWDHVVTIKIKLTDEDLKVEDNKPRVAQSWAPEFFRDPQTNNIHIIISLRLPSPIEPKPDFEMKTNFAPYIFTATSRDLKSWTPGKQLDVIGLTPADSYIDMFVIYNGSDKATPYHGFMKNEVEKHIEHLAAASVEGPWEFVQKGDFAGWGIKEGPAVVQKPGGGWRMWADDYHGHVMYADSNDLWNWTKMVDMPDGVSRKVRHGTILRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R432</accession>
    <name>A0A6A6R432_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R432"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="186" mass="20638" checksum="C8EF81D967744EAD" modified="2020-06-17" version="1">MPCPMLGVLGGFRHRRRIQPSQGPRTANMQFNGYDWQGRQLERRLNASGVRRMDSTLSAVQDLRNETVDCRPKHFPTTSPTSQPWAARGPSYSTKPTIAPIVLLRFSWRSQRIELLPEVNGRSRGTSVVQSEKVEDAVTAISKCTGYQYGSRPLGISHVRYTNISSGGEAMEGTEATGGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R539</accession>
    <name>A0A6A6R539_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_536178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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    </evidence>
    <sequence length="223" mass="24863" checksum="3E2FD59F11EB937E" modified="2020-06-17" version="1">MVHASVVEGGYTPMHMKIAENFPDAAVPGIEELLRRGADPHCVGFTSSSYGGDDSERLDTATSLAMRRSSSFFKWRQIVRDLGLNLDKFVADELEHAPLVIRGWTASSLSKLFELDFEPLEIEPDLCTQCGRVVYHTFDKDETWWEELLDELKASETGMNTDNAPSTPGAQSGLCERDDEEVHDPSSPVSSASTSSTELDEDLCWKCGIMQRTYGDDYDRGRL</sequence>
</entry>
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    <name>A0A6A6R6P5_9PEZI</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        </location>
    </feature>
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            <begin position="363"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="381" mass="40297" checksum="AED51EDD19DC19CE" modified="2020-06-17" version="1">MATTASRPPFNPVDTTSAALPAHDEVESPSLSSTNALARFEFETGHGREGTKILMVEWEDSPATRNVRGDWHVSWEGKSTVLSADDQPAGDIHRMYFLLAPGAAVPPLVVLTHRPRLPAEASEVVWHTNPLPAIFPPELGANARAAGKKGILHTIWAKKRLQVLSREIEKETRENVEGIGLEMASQEKEWIESTFGIAPKPVGLTISLAEAGGLAGLGPASPRTPGGGRLMEKLRGLKLGTSERDLSIGGRESGGLELSANNPLSPESSDVAVSSFAAFKGANPVALAAKPPQRPVGGVGIAPPQSIVAQQEKQQHDPGMASLNATFAAPSFESRGAPLPDDDREDGLFALPISPRSPEMTKSPFSFAQGETTKTEGELAS</sequence>
</entry>
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    <name>A0A6A6R6S2_9PEZI</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
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            <begin position="253"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="343" mass="39509" checksum="773117B373C1B20A" modified="2020-06-17" version="1">MSSDTDSIICNWEADPRDELFIDLARRNIPNQPFFRSVVNELNESRSRLILPALTKILKAFGWPTAMSGTGEHRRITFRGCLLETVQIFHRGRSSMAHRGVTILTEDARIQCDVGKKEGRYQFLAFLMNHEAAERKLAEGKENKFREVEEDLKKWTVWREARKYPGKLRLSRARRTRATHYVIQEAEDLTTTSHRQEALPGFNPWATFRPTKLSFCETNPDISDRAVESSPPSNTSPSKPPNPHTSPSSMHSSARRSKTPSKPHHRSQNCRIQKPNHSRMTKKSISRHGRDSILKDVSNWTPCFEDTVRPLISAPPPHHLCHTRYHWQTPLAHLELSGRRCQI</sequence>
</entry>
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    <name>A0A6A6R6W2_9PEZI</name>
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            <fullName evidence="2">SprT-like domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BU16DRAFT_578125</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="20772at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_ribbon_SprT"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="701" mass="77120" checksum="037ACD670D27FFF9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Glutathione transferase omega-1</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="31712" checksum="1F8BFDAA6934B497" modified="2020-06-17" version="1">MSDQKRTQQHPDSDLYPEATGLATATVKAHSTEHSLKLYAGWFCPFVQRAWMVLEEKNIPYQYIEVNPYHKPASLLSLNPRGLVPTLAYNNQPLYESTVLCEFLEDAFPSHAPALRPADPYTRARARIWTDFVGSRIIPAYHRFLQYQPARDGPEGLSAARAEFLGFLKEWTKATDPAGPWFLGGEFSLVDVALAPWAVRLWVFDYFKGGLGIPEEGEGGEDEAVWARWRKWSKAVEERKSVKETMSEREHYLPIYQRYADDVAQSEMAKASRAGRGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R783</accession>
    <name>A0A6A6R783_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_557918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R783"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="62" mass="6937" checksum="3FA427B76366D90E" modified="2020-06-17" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRITYTRRFVNVTMTGGKRKMNPNPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R798</accession>
    <name>A0A6A6R798_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_268787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R798"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="50310" checksum="E77BE3CE769468B7" modified="2020-06-17" version="1">MADEKNAIHSAAPSSPTHSKEYAIGDTEAVVFDDDDEHEVFKKNTDGVNFRTVGWVRASVIFLKIIFATGVLGIPSAMYSLGAVGGALSVIGWGALNTYTAVVQGDFRNNHPGCHSIADMAKVLGGTALKEVTGALFIIAYVLCTGSGILGVSIGLNALSTHAACSVWWSFLATVVVMAAASVRTFHKVAWLTWAGFASIFTAVFIVVIGVTTRDRPASAPQSGPYDFGYHVIAYPTFAAGMTASATIFVSSAGTSAFLPVISEMRQPKDYRKALFACMGIVQAAYLSFSLVVYKWCGKWVSNPSLGSAGPVIKKVAYGIGLVGLIVSACLYLHVAAKYMFVRILRNSKHLQANTVVHWSVWLGCTLGLASLAFILAEAIPIFSYLLALTGSICFAPLAIMLPGWLWIHDHGSWRRGGVAKMVVYYLHFLMIAIGAFLCVGGTYGTVLAIKAAYANGTVGTAFACADNSNSVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7E3</accession>
    <name>A0A6A6R7E3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_523887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2499407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="170" mass="19003" checksum="E88EF14990C80011" modified="2020-06-17" version="1">MSARPSYRLFQASRTFFRQPLLRRRINTAAQPEAPAQTGFAKVWNSPVGPKTVHFWAPIMKWALVLAGVSDFYRPVEALSLNTNAALMATGAIWTRWCFVIRPQNIFLAAVNFFLFLVGTTQVTRIMLWKRSQEGQPITEEAKALAVEAKDGVTAKTQEAVDAAKKYAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7K3</accession>
    <name>A0A6A6R7K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_524282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7K3"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="14">
        <location>
            <begin position="261"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2499840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="415" mass="44939" checksum="8C696CD9BE55102D" modified="2020-06-17" version="1">MATLGALKKHKVTIVGSGNWGTTMAKLVAENTKIHTDLFEETVQMWVHEEQVTIPKESRHFDPTSELANKPQKLSELVNKLHENVKYLPNITLPPNVIANADIVDACKNSTILVFVLPHQFIARACDQLKGKIVPYTRAISCTKGVDVSEKGIRLLSESIGVRLSIYCGALSGANIASEIAQEKYSETTVAYDPPPLDSRAPTPKGSPTSSNVDLISPSNPNPSARSARLQALPSDYPPLSHENVRKLFHRPYFHVRLVSDVAGVSLGGALKNIIALAAGFVDGLGWGDNAKAAVMRVGILEMVAFGKAFFEDSVHASTFTEESCGVADVVTSCMGGRNFKCAKMAIEKGISIDEVEKTQLNGQKLQGTSTAYEVNSFLKSQGMEAKFPLFTAVYNILEGNVKPEQIPDLIESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Y1</accession>
    <name>A0A6A6R7Y1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_276966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7Y1"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="339"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="339" mass="36444" checksum="F546B84AE962D038" modified="2020-06-17" version="1">MPGYRLPPPGDWARGGQPPLDPYRGGPPPPYGGPQQPAPRQRTAIACRYCRRRKIRCSGFEASEDGRCTNCLRFAQDCIFTPVSAQTQAFVPAHTRPWQGVGQAPQLYGAYGQPLPPQTHMQEAYAPPRAQGYPLPSPTGPYSAPGPYASPLSSVYDDRGARDAYNSRKRPLAEPHTPTLPRPNPASVSSQLPLHRGPGSEYTYPDPTALTPAAVSPASSSASYHSAPQQPQPNPYYTTQPPRRSSPQSAYSYDPSRTSSSPHTQAAPSTPGGTPQQAFAPENALRPLPPRSDGRTPPPPTSSSSTRPGMRISDIVGDSGQGRSSTDSDMLNQLNRRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R869</accession>
    <name>A0A6A6R869_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_557124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R869"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="125"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
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            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="438" mass="47756" checksum="0053956C4917AA10" modified="2020-06-17" version="1">MGKSPTPSPTSAPVGALKASSQAAAVPAAPTQLPVSPLLRPALGDETHDARRPSIQFIPHIQVGLPQGLPKAGRLQRRMSSPPPPPLFQPRVSFDTFDRPADFIEENSFTLITKHKDYEYTKRSRTFLCGLDSNDYSEYALQWLIDELVDDGDEIVCLRVVELDSKVAADSSIETGKYRKEAELLMKHIQTKNEDNKAINLILEFSLGKVNKVIDEMINLYEPAILVVGTRGRSLGGFQGLLPGSVSKYCLQHSPVPVIVVRPSTKRDKAKQKRKADGRHAYKDILDKAAPTTGHILNMNHRNSFIEEENLPASDDEAGAVAAAIGYKPPRETVHPLAHVQTAPGSLDSPELRSEHEGDFSPDDFRDQGVVMKSPHLQNLESPPLSDVSSSDDENGPEGGVPMDPEDSPDESAKPAASKAAERTSAEFVEPDDTPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8Z6</accession>
    <name>A0A6A6R8Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_452514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="3"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8Z6"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2500892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128976" checksum="4845A0E771B7E8FA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R909</accession>
    <name>A0A6A6R909_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_193721</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
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        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="288"/>
            <end position="418"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
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        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="424" mass="45421" checksum="4473ABACDBF6C06E" modified="2020-06-17" version="1">MAAYDSDSSGGEDNFTETNVLLGYASQEPTGDTVSHLGGVPAWLDDTTAPSGALAKCKVCNSLLSLLLELNGDLPEHFPGHQRRLYVFSCRRKACRRKEGSVRGIRGTRVTKVKEEKKKLAPEPSSVQESEKKAVQSNIGESLFGVKSPGASSGPVNPFANPFASGTASKGPVNPFATSKPTSTPEPASSTTTSATNAALTSLPATFAEKARIAPPTTPSESILPRPHEPWPDQAAFPEPYPRYHLDADYETLDAFPTPAIPETARMDVDEPSASSGGDKELFESTLDKEFQRFADQLAQNPEQVLRYEFKGTPLLYNRGDAVGKLLAPASHSQGGGKVVVKGGSASRMPRCKNCGSERVFELQLTPHAITELEGKSMSLDGMDWGTIILGVCSKDCVGSDVGEGEVGYLEEWVGVQWEEVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R9L1_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BU16DRAFT_569310</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="613"/>
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    </feature>
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        <location>
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            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
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            <end position="600"/>
        </location>
    </feature>
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        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2501072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="613" mass="65462" checksum="0B78DEE6FADF03BD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA34</accession>
    <name>A0A6A6RA34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_534279</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3792384at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="13516" checksum="5674D5699D86E56A" modified="2020-06-17" version="1">MATDPRPPAYQSRPPSESNSTIIPIEVPINELPPSYADATQSETAPLLSGPPPTYGTHERVYPSPPASVHSSATSSAHEAGIRSLPEWVGQALVVLCFLGILYAFWRVIEEEGEEPFTTERWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAG0</accession>
    <name>A0A6A6RAG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative TfdA family taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_613615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAG0"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="42"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2501778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="40424" checksum="9B4B00F14F246357" modified="2020-06-17" version="1">MAQAISNSNAPIRSTHAKSKAVKEAPRVPLKYSGSLDRFKSFDITPIIGREFQDVQLSSLLSDDRKLRDLAILVSQRGVVFFRDQDLEIDQQKVLGEKLGRLSGKPETSKLHRHAMTDKKAKRVVDGEPKPEEEVMVISSENAKLAHQGHKSTLKPLASTLWHSDITFEHVPSDYAVLKMTVVPETGGDTIWASGYEAYDRLSPAWKRFAESLTATHHNATLKKAAKEGGGDLISGDRGSPDNGGLDFEASHPVVRTNPVTGWKSLMAAGHQVHDGRFNNVTPREDEILKSYFLQLIAENHDLQVRFKWRTNDIAIWDNRSCFHTATFDYDANRSGNRIVSIGEKPYLDPKSTGRRFALAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBH6</accession>
    <name>A0A6A6RBH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_520954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBH6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="75" mass="8457" checksum="74A9005749FD8662" modified="2020-06-17" version="1">MSTQSPPSLSFVLIFSQLAKPIPNTPSKRGENDVNARTRETITEPEHHYPTLHSLKAPRAVARSKKSQRNHFHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC41</accession>
    <name>A0A6A6RC41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_533981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000142">
        <property type="entry name" value="Regulatory protein ral2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1530"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1593"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD10</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="488" mass="54317" checksum="6F8A1B88961C6000" modified="2020-06-17" version="1">MAVTFGTNDLLEYDAKHSVLICRECKYAIQKSALGSHLLRHKIYRRERQRLLSSIAELQLVEPDDVQLPPAGFPPVAGLPVISGYRCTATGCESLCASSKRMRRHWSESHGVSDPPDSCARSVNLQTFFRGTKVKYFEVASPEPLVTGEGMVAQRHDLDLVPTPASVPPPGPRYDLDLETLKYFHHFTTATSLTLPTGNHEPAMYWQLDVVARALQQRWLMCGLLAISASHLAVLPSDETTKQVHRERSEWFLQEFYAGWGDVLQSPSVAGLEEAKSAGAQMICIQRCCHWTSEIPALSQGLIPEPTAFDLQSFTTTVQGCADPNLALHSAFSSDDMPEGSSDAAVSGNVPSALLDRFRALPYRMAEALEKPDNALDFFATLSAIDALVECCSLSYASDDVEAVWTGMASWSRPRRLSDHFNQMVWHRNPAALIVFAHWLLLVERAERHCWFLKGSATMLLRQIRGYLPDDSSVHRLVGDLIGREDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD57</accession>
    <name>A0A6A6RD57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_10818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD57"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="192" mass="20403" checksum="D6E82BEDA469904C" modified="2020-06-17" version="1">MTSTLAMQFASFRLASRAIPRRTPLLKAAPRCAIHGPEYTPLSTFIFSLPLPLTVTIVASHRATTLHTASLTLIRRHSPPNGPQPRPPPHHCCAVHGFHGLCGTAALKLQFTRTIAPQLAPLHPPVPFLSSAILPCARSLPVQLASRSPVRARSSKPARAAATSPKPTTPRRLSTSTLSTSSLPPAPAASHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDF2</accession>
    <name>A0A6A6RDF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_521446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDF2"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="78"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="429" mass="48332" checksum="43449658776050ED" modified="2020-06-17" version="1">MSAFQSSLADLDHRDRRPGQEKRVEKSAAALTDVPSAPLSDSRSLSPAAAEKIAQIAAACSNEDLNALIDLATTKDGLVEDNLRRTAWPLLLGSNNTPLDNQVPWTSLPPHRDEDQVKLDVHRSFVYYPNNESDKQLDKRKRELSDVITEVLRRHPILCYFQGYHDIVQVLLLVLGAKDSPAAVTRLSLLRIRDFMLPSLDAAISHLHLLHPILDTVDPALREHLSHTQPFFALAATLTLYAHDIQEYGDIARLFDFFLAREAVIPVYFFAVVVLARKEELFEIPPDEPEMLHSILCKLPKPLDLELLISNTTSLFDRHPPKSLPYHAWRRVSSYSVLKTTQNPSSVARQTLEEGHALFSKQEVEMRRAKAIHKAMNNVKRQAWLYRRPAGAFGLAVAVGLVAWWLGKSPITGVGRLSESLRRIMAFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE53</accession>
    <name>A0A6A6RE53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_588034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE53"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="261" mass="28130" checksum="F0B941F1C96A9A15" modified="2020-06-17" version="1">MSRPSILLIPGASALPEFYDSVVDPVKAKGYDIRGLHMPSVGLEAGAGRKGSSPSMFDDAALIANEVEKLADEGKDVILITHSYGGVPATQSTKGLSKEERHEKGKSGGIVRIAYITSLVPAVGTAAMSVLADLPKNQQLDFRIDEQGWMHHVDVSRSAAVTFSDISKEEGEIWIKKFPLHSAVSFTNELTHAGYKTIPVSYLLCEGDLCIPAHKQKAGIELIEKESGKKVDVTYIKAGHCPMISKPQEVVDWILGVAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REJ4</accession>
    <name>A0A6A6REJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_521824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1081"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="716"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1433"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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        </location>
    </feature>
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            <end position="518"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="855"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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            <end position="947"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1110"/>
        </location>
        <ligand>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1501" mass="162701" checksum="44CD7E86587A2389" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REY7</accession>
    <name>A0A6A6REY7_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_611982</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <begin position="145"/>
            <end position="340"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="184"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="432" mass="46983" checksum="DB01E355492EC4D0" modified="2020-06-17" version="1">MSTASSCAPTLSAGLGLPLYTSSSLKRTASPCTDPRTPPCSPKNTEQIWDEYERCARERSKSRETSFSSLHLRALESQRFSSGTVLDIIKSYDPYSSPKAPAASPASSVAPSPRIGTPPSFSQRKNMLQGTSLTRTMCKACENSATSPSTLCEDCKPKETTATSKPHIEDTSRPLSTEQRTSTAVHLGKRQKLHTPSNSRSSAASSTSKSIQTSPKRSAKANQRTLPIRLSSLDYSRTHDRPSESPELHHDLPSSKTSTPASRIPRKPVPQPTTPVGCSFPLLLPTFNHSNITSPPPSTPPSTASSRHNPNSLLASSPEYHLSLYPSTPTTIGTTRMSTSANTPLHRASYSLQNTVSVWEDDDDEKVGLVDYLRRGWRGSRSSFGFVGRRESGSATGAGVGVILEREVDGKSRQRGRWRRWTRCGCFGCKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIA4</accession>
    <name>A0A6A6RIA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_521792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RIA4"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2503197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="836" mass="95610" checksum="35970619745257B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7H3</accession>
    <name>A0A6A6Q7H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_231075</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7H3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="16">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="15">
        <location>
            <begin position="271"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="17">
        <location>
            <begin position="589"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2488330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="750" mass="81060" checksum="796586A7AC6DE378" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8D8</accession>
    <name>A0A6A6Q8D8_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
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    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2488552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="375" mass="41430" checksum="0CD2AC79FB6EA6C6" modified="2020-06-17" version="1">MLFSQIVARSTFILGRVYEALAGSPDGGNIPPTRDYFYVGGHYENITTGNSTNQYMIGHIYVERLTPPKVTQPYPIIFVAGSGQTGTNFLTTPDNRPGWSTHFLSLGYVVYLTDQPSRGRSPWYPGIGSIAAFDTHKVETLFTAPEDYGLWPQAHLHTQWPGTGHPGDPVFDAFYATQVQLQADKLISEETNAKAYAALLDRIGPAHLITHSQAGAYGWRIGDARPNLVKAIVALEPSGPPFENAFPFEGRERTWGITDLEVTYEPTAGPNATDLYTVTIAAKDEEHTSCILQAEPAKRLKNLSRVKVLVVTAEASFHQPYDYCTVLYLRQAGVEVEFLDLGEVGVRGNGHMMFMELNGEQIADQVGAWFERQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q8F6_9PEZI</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8F6"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5025345806" description="BYS1 domain protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18325" checksum="0B2DF26A0BD57F3B" modified="2020-06-17" version="1">MRFTFLLPLLLAPSTLAADLWIYNACGSNPLGAIPIYTVGATTRFEGMSLWEEWTHLPLHHDAVTGGVSLKFGDFEAGQPHLELNYNVDDAAGRVFYTLENVNGALFDGRLVELRVPGCPGVSWLKGSGEGVGTLSCEGGASLVLSFCGTDYWPRRGVGRIHRRRPFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q9D5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
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        <name evidence="7" type="ORF">BU16DRAFT_473612</name>
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        <lineage>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="88"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="399"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="620" mass="68944" checksum="8AD5BAB7A87EF6AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA33</accession>
    <name>A0A6A6QA33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
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        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="7" type="ORF">BU16DRAFT_531887</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA33"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025411980" description="D-arabinono-1,4-lactone oxidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="538" mass="60173" checksum="F4D2242F792BB9E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA47</accession>
    <name>A0A6A6QA47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_518954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="485" mass="53738" checksum="8643B7FBADC1E88D" modified="2020-06-17" version="1">MADEIAQEYDVVVLGTGLTECVLSGVLSVKGKKVLHIDRNDHYGGSELAPPQLQTELIFNSESASINIEALFKKYGNYTKGEEPWKKYGRVNDWNIDLVSKLLMSNGELINILVSTDVTRYLEFKQIAGSYVQQGSGAKATVAKVPSDAGEALRSSLMGLFEKRRARNFLEWVGSYKDDDPATHKGLDLRSCTMKDVFDKFGLEATTRDFIGHSMALYQSDDYITEKGMAEDAVSRIRLYVNSMARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTEVEEILYDGSKVAGIKATMKERGEEGEGMKFTTKCKKILADPSYFPGKATVTGHLLKAICILNHPIASTDNSDSLQLIIPQSQVGRKHDIYIAVVSSAHNVCPKGYYIAIVSTIAEGDSNHHLELQPGLDRLGRIEEKFMGPPIPLYEPLESGVNDSIYLSKSYDATSHFETTTDDIKDIYRRAEGHELVVEGLRDGQNLVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB47</accession>
    <name>A0A6A6QB47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_163146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB47"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025427393" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="23330" checksum="C4EA8B873C3E8925" modified="2020-06-17" version="1">MILPALAPLLLLLGPLALAQTTTIPIFGLDDRGSGNNVYTVIINWSGSILAVNSTATTFVVTSTLVQHVTPVYQGVTARWTYYSTIGIPQTITQGPSTYEYTTSYGNKGMEDVTACRLFGTTEARCNFTGASWYGTHDTKSFTWKANQTDKDGFWGHFAPVTVSGGLEKIGASVSATGIATRTSTGAFSEPVKTGEAAGRMTKLELAAFSAILTIVFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBI7</accession>
    <name>A0A6A6QBI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_220785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBI7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="175" mass="19733" checksum="CB745205DC87B2D0" modified="2020-06-17" version="1">MHGTPDKPPTTGSRRCMAACRLPSRSRLKPSFDMGGLMENWSPSCRNRWAPRCDILRLPPLTQLSASHIGASTPVCSRHASHAHAEGEHRVVDLRSYTEYSSTAAEKRRAKVASGYMHARDVASLVLHQKLNLRWPRWEIRLPASRRWKHDGRPIELRSRQTLSNAFSADDCGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QBM7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_622931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="191" mass="21502" checksum="FE82C1017199A73D" modified="2020-06-17" version="1">MEDVPTEEELILMRELAELYEAREANAEGFRENKDQFSKGHGTFAAIQQRYDNETRRRLTLDDDIESEIFEKSKRLRAIKVSKDRSYLRPFNNKSSPFKFKSEPVDRVQAHSTVSDGVQASVSEHPTESLAQSTSPDTCRRGLHSSMQATPEAECFGNTPILRSTSARSGLVNPNSLGTLNYYNSAPILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCF8</accession>
    <name>A0A6A6QCF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_437842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCF8"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="34250" checksum="DCFC54A57E1E0944" modified="2020-06-17" version="1" fragment="single">LHNEADRQVFQTEVNKRMDVPNGYLKVGVLMLRWQKGLDQFPKHDQEIDDLREVFEDLFHYECTIVELHNNKQPMLQLRSAIAKHVEKYDGPNNLEISATNDFDLPRGGGKYQPTALWSCADKQLLDETDGGPESDVLCLMDCCFASNIQKCSTSHRRAVQLISASSKDMATPGPGENSFTTALIVALRHLLKKDGKTGFPTQKLHQEILSKRPEPVAMLFDRFNRHAKRIKLAPLVKPNREEQHKIEVFYQEPEKSSLNIRFSLKQSRLSECQIKAFARELPVACEKAEIPVRKIDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCI5</accession>
    <name>A0A6A6QCI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_531241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="110"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="688" mass="74812" checksum="887838E8E5C4C64E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCK1</accession>
    <name>A0A6A6QCK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCK1"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41561" checksum="6D892F13B7E0C632" modified="2020-06-17" version="1">MRGIDSPSVETEETCRNNSPSITNYTWDHQIFGPECSYVSDLTTDFGPVEGNPLGSHVDASSISGEAQSQLASNAITLSEQSLQSSFSIPASLSYQDPSSLFERRKFSEPELELTGDLALHILRSYPYMMANQGSVPPFIHPKYQYLSESDTARPNPLDAALNLAKMLLHGRRMNKSLIWGLIRIEQERLLNEYPSFSKWEVLETLQALVIYILLRIIEGRHDYTNFDTQLLASINAICRHITSKYGNLISPDELRGRMISWKDWVFFESRRRIIHAQITTPSQAMPEYPYSPAPSPITMWRAENEFDWTVDYTEYLHKNMMYGMLRNGDLVKLKEAAGSHHDRWYAYADSFGLLVTLVANMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCK9</accession>
    <name>A0A6A6QCK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_166657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2489881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="132" mass="13986" checksum="38EBA736ED85ED72" modified="2020-06-17" version="1">MSVAVRIWRCVPAPADGWKVGMKTRLGSGLAFITSLGTTSQQASRSHNPGNSINTFFTSAAPFHQQLHQRQSTLPTKTPPLNQSQLPWVLCGLNTLVADTPAEESSSTSMALAARLSDSPLADSAASARVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD32</accession>
    <name>A0A6A6QD32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose transport protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_470272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="543" mass="58679" checksum="5C8A3303A99EB1A9" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDC7</accession>
    <name>A0A6A6QDC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium transporter ALR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_152708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
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        <property type="protein sequence ID" value="KAF2490428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="668" mass="74504" checksum="D7DFE2AF8A2012AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDG1</accession>
    <name>A0A6A6QDG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_169329</name>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF384">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="463" mass="50690" checksum="4F19939F959799A2" modified="2020-06-17" version="1">MASNPPPQLPPGMTSSLRGISETYSFHASPEAFIASRVLAYQKEHPSLGTSQAIIRAKILNRNVAVVSSHAQITHILKSSDGYTAGAAYAELMAPFFPSPNLLLLEGEEHVHIRQAWEGRLEGMFGKVEGLVKRLTKEHFAPLANGEEVELYETLKTLSWKILLGVFISLIPEEDEIDVVEKHQETLLRGQFSLMPISVNAGFWHSPRKRGIDAKTRLQEILGERLKEDPARCPFNLSSGEQIDEAANHSVLFTSSLAAKAIASFMTALFLNIFFFPGSKKGFAATLANTADGGSCKKALRSIVLETERLSPPIVGIMRRSTQENTVPSPHDQPDGLIPSGWDVWLYFVGGGRDPTIYGDSWGRFEPGRYLDSDVSPAFAFGAGSKTCLGQHLIREIVTAVAEACLDMRLNLDGDVTASGVRARLGWTENDEVSPEVWAADMKQLPTQHPTKPVRVRISSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDP4</accession>
    <name>A0A6A6QDP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase-like protein DCLK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_531474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4062651at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="297"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="615" mass="68481" checksum="66E3BFA87849A44A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDQ6</accession>
    <name>A0A6A6QDQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDQ6"/>
    <dbReference type="OrthoDB" id="10455813at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="343" mass="39486" checksum="BD98A82B61DE48A4" modified="2020-06-17" version="1">MCECKAPPTPTDAMEVGAQRDTPPESHVLAAAILDLLVPKELDDLELRPDELRETWPEVADDMYAFRLNAVRKLATTCDRYNKRYLCHNTPLLSDVQLVAFSRAREAEFFKFFLRQEMEYKPTSVAWYTEQIEKENSAEKNERAKWTKRVETFKTYWESVKLLEERLKPMSLVDRSGALGLPHIARRQLKLHKNFKQLREKALTRLYKQHGPSKLWGFYDLPQWPKSKEAAVVHSCVTREGQVFRWFMGLQDRLQTEKGYLEGIDEEITKVRAMRKEAEGKLKEIGGVAEPSGTAVEKTRTEEEAKKKEDRGTSTAVKVELAPGVKRGAPEDAEGLLKYLKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDR0</accession>
    <name>A0A6A6QDR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_544466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDR0"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39182" checksum="F9585E9B3D4A1E46" modified="2020-06-17" version="1">MSKPQASSTSSRLQEGSMTLCQGESRTKLELKLTAIDTSTLAIGLAPKTAKAALYFLKTLYLFSKSDIPTYVVPCTLFGTLSTLSGSSLISAPVSIPTLLLRVPTVALWAWLFCVFFNCSNQRSPDSVLEDTINKPHRPIPAGRITSSQTGLCMVIGVPSVLLFNYFLLGAWEEMAIMYVVMYLYNDLHLGDNFFWKNFLIATAGNGVYNAGSLRLASGTARASYFTSDASELLTPTAMKWIALVSSAVLITMHSQDLRDLEGDRARDRRTLPIVFGENIARWSIAVPVLFFSLAAAWFWNSGFIGYTEICVPGSIVAYRIIFLRDTKQDRKTYTLWAVWLMALYALPLLKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEF2</accession>
    <name>A0A6A6QEF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEF2"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="556" mass="61788" checksum="47374D97A6B9D876" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QES7</accession>
    <name>A0A6A6QES7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_493378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QES7"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="26602" checksum="093F6B709BCB0220" modified="2020-06-17" version="1">MPYDLKSRNVLITGGSRGLGAVITRLFASEGANIAINYVSARAPADSLAADISKEYGVKAIVVQADCGNLADCARCVQEAVEGLGGIDVLVGNAGWTQFGTFADLDALTEEEWDKCWAVNVKGQHALLRAALPTFNANPDGGAFIMTSSVAGVSQGGSSMAYAITKAAQLHLMKCLASTQGPKVRVNAVLPGLLMTEWGLKYSPEMIKSIEDRAALKMATDLVDCANAFIMLAKNSSMTGQKIQVDAGLVISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFQ3</accession>
    <name>A0A6A6QFQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_145477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFQ3"/>
    <dbReference type="OrthoDB" id="10366072at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="19852" checksum="237893C608D52B8D" modified="2020-06-17" version="1">MPSHQRPELQPRPASVATVSILSGGPTERFEMYPGRIHFWGPHDAFLFQCPRLQLPTDPSIDVDFPRDATVYIEPSDIELSEDVVSVMHDEGTSHRIAMSKARGEMDQSPECVLQALPKRQYRIFSRDFPSVLIEWNNVMVEIEAEGEVCLRRWTIFPKPEKTGQSKIKENATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFW3</accession>
    <name>A0A6A6QFW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_492295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
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            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2491298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="35936" checksum="2BD39C026574A8EA" modified="2020-06-17" version="1">MSEASKTAAEKLAESTQAAPTSATAQQSDNVAHALAGAGGGLFSMALTYPLITLSTRAQVESKRAQSSTLDAARRIIKREGLVGLYAGLESALFGISVTNFVYYYWYEWTRAFFEKAAIKAGRASKKLTTVESIFAGAIAGSLTVMFTNPIWVVNTRMTARKSQSDEQVLPGAKPAKAPSTIGTLLSIIRDEGPMRLFAGVMPALVLVINPILQYTVFEQLKNTLEKRRRVTPTDAFYLGAFGKLMATSITYPYITVKSRMHVAGRDGPKEDMMSTFRRIIREEGWAGLYGGIGPKVTQSVITAAFLFAFKDALYGMTVTARRKIALKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFZ4</accession>
    <name>A0A6A6QFZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_470413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="122"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="680" mass="77265" checksum="226ABA54870E9424" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG82</accession>
    <name>A0A6A6QG82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG82"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="132" mass="14196" checksum="76130D34F5DF1B60" modified="2020-06-17" version="1">MAQTVQFAEVLEMVRYIPTDEEALVGATVPASPGLERADDGLGPRGCLLRRKWRRYGTMLVLLIVGGLLFEIPGFLKFVRETAVKDDKKHQSAPAAVATDTDSAVGGGPAQGMKFAYHVKLSTPGLGILLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGW4</accession>
    <name>A0A6A6QGW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_468728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGW4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="521" mass="58287" checksum="021BC89119DAE47D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGZ8</accession>
    <name>A0A6A6QGZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_468627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGZ8"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2491379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="232" mass="26670" checksum="875A59787E0DB29C" modified="2020-06-17" version="1">MEEYAPLASLSLTHVHYNPADRLSYVCAWLALVPQGLCIVYATLIWSNREIEILLMFTGQMACEGVNWGLKRLIKEERPREMHGKGYGMPSSHAQFVTFFSLTLTMFLLFRHVPNPTETHTPFSFFQRLLLSIAALISAAAVAVSRIYLNYHTPKQVLVGCTAGAIFAILWFGITTYLRRAGWVDWGLDTFIARQFRMRDLVVEEDLVDSGWARWEDRRLKRRALANGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH23</accession>
    <name>A0A6A6QH23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_542477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH23"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="79"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="547" mass="59550" checksum="601B9F9AFE07C4E4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH60</accession>
    <name>A0A6A6QH60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH60"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025332675" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="133" mass="13354" checksum="96E8DCD7F480EE5A" modified="2020-06-17" version="1">MRFSTIILPVSAVLGLATAQSCSGGTEPTYSDCVAASNLIDTSSTYEAGAVVSYGGCAATVEDSSLGGKEFQVLAVSIISACGTSGSAQSGDSVVSVAPAGAKIRRDLDDVKNIGDKLNGGDKRAVRSAKFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH64</accession>
    <name>A0A6A6QH64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_529918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH64"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
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    <sequence length="846" mass="93624" checksum="635682BC3BA6CABA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHW8</accession>
    <name>A0A6A6QHW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_574142</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHW8"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2492005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="40922" checksum="C5EDD2B1191670F8" modified="2020-06-17" version="1">MVVGSVLVAGGTGYIGSFTALALLEADYKVVIVDSLYNSSEEAINRIELISGKRPAFYKLDVTDEAAIDKVFDEHPDIDNVIHFAALKAVGESAEIPLEYYRVNVGGSVALLRSMEKHNVTNVVFSSSATVYGDATRFPNMIPIPETCPIGPTNTYGRTKSTVESIITDQIEAQRNKAKKAGKSGEEWNAALLRYFNPCGSHPSGIMGEDPLGIPYNLLPLLAQVAIGKREKLLVFGDDYSSKDGTAIRDYIHVLDLAKGHLVALNYLREHHPGVKAWNLGSGRGSTVFDMIKAFSAAVGHDLPYQVVERRPGDVLDLTANPSLANKELNWKTELTLEDACRDLWKWTKNNPNGYNQSPPKEFLEELAASRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHY3</accession>
    <name>A0A6A6QHY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_142711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHY3"/>
    <dbReference type="OrthoDB" id="3946796at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="659" mass="70986" checksum="A59A58F7A88772BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ28</accession>
    <name>A0A6A6QJ28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_491316</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ28"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
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        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
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            <begin position="29"/>
            <end position="187"/>
        </location>
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        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
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            <begin position="185"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
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            <begin position="240"/>
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        </location>
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        </location>
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            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="40247" checksum="AEBC635E0AFCC3AC" modified="2020-06-17" version="1">MVQENTTGNPLAAGSLAVFMAASLPKGASPPLKNPWDAIALAVHAGMIAVGFRLVGLGEDHRIDAASDAQDPEPLPSEWNATSSYAFRYRHAQSSMQYLVKVNRLGSKAVVLAMAVGADKTTTFEVTVKDYVSESSIQSTAFPSDASTESISNTLRDVFISVGRLGDFGALLKISVIQKLAPGLNKEGYEDSTETASASSNNQRRSPPPRQPQAPQYDPLRDDPQQPPPARPYPFNDPLAVPPRRGPLPDPMPGFEDEYEINRPARGYGVPGGRFPNLGDNDLYPQGLGPNDPLRPHFGGGLPRPGAGGGGMHPTFDDPMFGGRGGVGGGYDPMAPPGARYDPTGPGGAPRDGRGGMGGPGFPGGGGMGGRPPNPFGGYGDGDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ61</accession>
    <name>A0A6A6QJ61_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">PEP phosphonomutase-like protein</fullName>
        </submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="27845" checksum="05F5B4FB2FDDA7B9" modified="2020-06-17" version="1">MSSSPLNTLAQTLKSLHRPGDPLMLTNTYDALTTRIIAANPLAPALATASYAIAASAGLEDDALDLPTNLAGIRAIAAVANEFKKPLTADFQDGYGDRLEEGVRELIQAGVVGMNLEDYGREKGALYDIATACGRIKAVLRTAGELGVPDFVVNARTDALLHGGSVADAVERGRAYLAAGATTVFVWGGRARGGIRREEVKQLADAFGGMLNVSLRLDEVDEKGGKNLTRRELGELGVARISVGPGLQAKAMAAFKREAEKVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJD9</accession>
    <name>A0A6A6QJD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BU16DRAFT_552093</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
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                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="418" mass="45148" checksum="55BC5A781D3D8914" modified="2020-06-17" version="1">MLEDKYVGLALAVTSSLAIGTSFVITKKGLNEAADKHGFEGDGYSYLRSPTWWAGIVTMVLGEIFNFAAYAFAPAILVTPLGALSVLIGSVLGSYFLNEKLGLLGKIGCAICLIGSVIIVLHAPPDTPVESIDEILNFAIQPGFLIYCLITAIFAIVMIYKISPKYGRKNPLIYLSICSTVGSVSIMAIKAFGIALKMTFAGNNQFTHPSTYVFVIVVIVCILTQMNYFNKALSQFSTNIVNPLYYVTFTTCTLVASFILFRGFNTTSAVNTLSLLCGFLIIFSGVYLLNLSREDPDGNKHLGNRLTDAPPADGISGVYTRRSMQARRSSIENGFRSPYLSGGSARNSFSEREGLVRSYDVENQSFGLGELVEDSDEGEAGGKRTSFDEVLPDANSNASGSVRVKKQSVRGGMKGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJH6</accession>
    <name>A0A6A6QJH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_583740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3781081at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="229" mass="26424" checksum="F864AD24DDB0F93C" modified="2020-06-17" version="1">MIWRYTISTSAGRILIDSWAFPHSPISTLSPTFIPPICRVNRQLKEEVLQALLTLSKFRVTSCGRIPFMKWLATFPNNDGFAAVRHLDFSDVFSGYWKSQLSLTLQCVGLRTVEMTFPLQRCVVPPGMATGRFPMQRPVEEGVEEIVEERQLGELLRCEKLEWVVLEFCTSEFLRLLTLDERERLDDNITAVAEWLEEGFWKRGMNTFVLKRLTGEMYYGTYYTVDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJR6</accession>
    <name>A0A6A6QJR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_593821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJR6"/>
    <dbReference type="OrthoDB" id="10402872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
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    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20213" checksum="913667AD64F80D25" modified="2020-06-17" version="1">MNAQPAKRDSNCVSEKRKEQNRQSQRVYREKKKKRLQNLERLAASQKWAEIAGSSSASDTFPSEQSTLYLPRPVGLIESRMTRRQPLDLQAPISVKDQVLGGAERVPIDNSATPAVEPPSKPFAPHLHDYPGRSHQALPSSFSIMNSPRQTDSPIDTASFDTYPGIPYGRFNTFKIPQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK17</accession>
    <name>A0A6A6QK17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK17"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025617018" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13371" checksum="63F88F579C8E3BB7" modified="2020-06-17" version="1">MKAIVLLLSWLILQITALVGAAPHDRHLHSLAHLRRGAVGGVYICKDVNLKGTCTYYDALNQCINIYGPMDDNASSVVPIHGSVCVFYSNAGCTGRSLTTDKPVYSLGIFGWNDQISSVKCSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKS7</accession>
    <name>A0A6A6QKS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_592254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="529" mass="59770" checksum="DBE000EEAB9E98E5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM12</accession>
    <name>A0A6A6QM12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_465305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM12"/>
    <dbReference type="OrthoDB" id="3937708at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025439740" description="Expansin-like EG45 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16784" checksum="19F9AEC1D5461438" modified="2020-06-17" version="1">MSSLKTLACRVGLLLLMARSAMADCESFGMDFQDGGSYFQNSLSSDPFTFVSQFEALTTCEGCDNDTATNVFVDPNGDQYLCTDTALQPDDTDELSTCPLNKNQLWSGAWSVLILSNNGNDDPIAYERDFELSVGPQNTSTVCFPIYVFADLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMT7</accession>
    <name>A0A6A6QMT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMT7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="141"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="424" mass="48464" checksum="9D9DBEB8AE7B7A1F" modified="2020-06-17" version="1">MPSIPSLPNDIHTRLYDEGSYRLSALVAGAHVESQCLGHSTLVWYVDKQPSPEASEEKRQVRTEMKSYSTFPKTFHYECKIVSGGTIKFDGKRDPSYMSVSMGTKYNGNLLEMPAHPSTLVKSSVQNLDPADWMRVIRQQHPGTHKLSSLTIPGTHNSFARVGYVEASPIFPDFVREFAECQTYGIREQLLMGVRFIDLRTSGTDLRLRHGRIGLKGHLREALDAIAEFLQQHSHETVLVQAKRDMESLTGDRQGETPETRRAVEDAFSSYPCSYVETREPSLDECRGKMVLLSTDHATKGINLSPIRDGSPNINWDYEDVEQHWKDVARRLEWNVNNSSTDDGFWYHCGCNSYWFPPGNVLSNVVAIEKHGYRTPRDHSNHLNWRMSELIKNQYWDKPNRLGLVQLDFAYPTLVKQLLLTNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QND1</accession>
    <name>A0A6A6QND1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_619117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QND1"/>
    <dbReference type="OrthoDB" id="5222339at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="48935" checksum="2E2AF0EDA75D1F1C" modified="2020-06-17" version="1">MESLLPKRRRMTSSGAAAATPARADQTSTPPQPSQASLQPHTYTSVGSNNHSYPSFIPSLITTPLPGFEKRKMEVATPLASQNSTHAPPSTDQTRSLPGAPSVLQNLLSIDEFEKQHEAAVAAAKAQAQSTPTPQPIPISTRSSANTQLFVQRCQALAIPQPIFSFNGDASLPSWNCTLTLHAAGSPHSLTTTSPFTSKKEAKEAASTLGLALLSSLEASGTLSTPSKTKKRTPTPTPITITPEEPQENFTGILMEFCQASKIPVPTFAEFKTGTCFSAELSLASHRPEDGPFGGRAVLHPSKKAARAAAAREAVLWLRAQGQLPAVHEPASAKKQRKTAGGSEDAAVQLPAHPAAARVLALASELGLPQPEYQWAAPSALAPGLFTVSSLFPGSGVGGEDGVVATARHVFGKKAAREECARLTVVELEGVLERRRGVLGKVLGNEEGKREVEMGEGDEEYHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPL5</accession>
    <name>A0A6A6QPL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_573330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPL5"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="104"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="355" mass="39321" checksum="A93A5E619875CD17" modified="2020-06-17" version="1">MTKTLDMSTSKIPKVGNRTTLAPSISSFLKHNPSLHLGGADAFTDERRHHTEVFGIHALPKEKVHPIHEVEFTAVRGPHGTIPVRVLYPKSGEERRKKGEAAALVYFHGGGYTVGTVDEFENGLRQLAEESGVQIYAIDYRPAPEFAHPMQLDEYDAIISWLRSSEGKSRGVSSSLICGGGDSAGGNMTAALCLRRQDHKLPPLAAQILLYPEARLPFDTPAASENNSALYLECNGIFSFAYHYLPRGIPPAHRYIPPGMQEIKDLKGQPKAVVCTAGFDPLRDVGVEYARKLEEAGDVVVWRHFERLTHGWLQMGPWSEEAENAIKDLAREVKKLVYDVTLSTTSRLYRPGLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPR4</accession>
    <name>A0A6A6QPR4_9PEZI</name>
    <protein>
        <submittedName>
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                <person name="Goodwin S."/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="669" mass="73222" checksum="B40A50CA11FD34D5" modified="2020-06-17" version="1"> </sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="426"/>
        </location>
    </feature>
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        <location>
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            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495240.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59320" checksum="294F8EB0BBD93969" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTM6</accession>
    <name>A0A6A6QTM6_9PEZI</name>
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    </protein>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTM6"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2495464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="103" mass="11921" checksum="CABE35B81F573E75" modified="2020-06-17" version="1">MSGYDKYACTYRCDYQCPNFVWRNGDACAYCQAIGHRSNPPRETVIEKEMVGPDGRPHPNNPVTRGYNSYHCINRLESDCTNMVRRRDDICARCIVDGRPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUQ3</accession>
    <name>A0A6A6QUQ3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_539924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="87"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="730" mass="80817" checksum="BD80FA55CA476AE9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWS7</accession>
    <name>A0A6A6QWS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_538720</name>
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    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWS7"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="234"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="407" mass="44118" checksum="10B2997F74CF408B" modified="2020-06-17" version="1">MPISHPQPQDAQDEGPDETLTSGQPTRERAWRRVYHNNKGVFLILLAQVAGSSMDAIARFLQLGDGGMHPFQIIVARMSVTFVLSSMYMWLTKVHDFPLGKKSVRGLLVLRALFGFFGLWCLYCKIPLFHIIPYSYRNGGRLLKVSLDSVHYLPLAEATVFRFLVPIVTAWACSLLLGAVFSWKDLCAGVLALVGVVIIAHPAALFGDKANSTNMGNPVDEVTTTQRLIAIAISVLGVLGASGAYTMIRVIGDRAHALVSVNYFAFVSTVGSTLILLITPNIGFVKPQGPREWALLSLLGVLGFILQFLLTAGLQLDKSSKATSILYTQVVFALLFDWSIWGVLPGMSSFVGGAIVIASTLWSALQKPQKAVKDTPKTAAVDEETALLGAQIEDVEEAAQRRASTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXG7</accession>
    <name>A0A6A6QXG7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_580943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXG7"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="405" mass="43584" checksum="342364ADF0D43A9C" modified="2020-06-17" version="1">MMLEGDLSTVGGYCHLGLDWGMLRDSMPPFEDGIAERLKVGWRTTEENAPKELSDGLEPVDENIPEGDPKEAVAVEDTSEGESVDEPDCSMDADDGEVDLKVPMLEIEKIKTDDDIAATTVVLGATPVVSKDAEVIGYIDELEDEPLWGAELDPVSRELDAMIIDGNNIEVVTAVLVTDEETWGATELVCVELYIEVLATEVLIVEEGIFEDEIGDVLELEPLVPNDIVSVVGEIAVNTSDVEVLRLGELVPTDAVSTVLSIDAEFIEDNGAELLREELPDRDAEEELVIAVLVLLMPKDDVEGVVCIGVKALLGTVLIGDTEIVEGVPLGDAVLELLVVLDERRMLDVVLRLSAEIEETAANESAGSAGEKKVFHHCPSNTSKAGATFAIQSRFSGESWKSGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXK2</accession>
    <name>A0A6A6QXK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_356312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXK2"/>
    <dbReference type="OrthoDB" id="5410873at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41411" checksum="510A46E5C8ECEB09" modified="2020-06-17" version="1">MVCPLLGLSDELQLMIVELVVAQDHGREDLVSLSSTCSTYRLLLAPIIFDRVTLLNDAESAASAIALANSHHGQYVKQLRFEGSLNRDGYRRVIEQHTEGLDINKLRTIVQEAREKLFPESVYRVLSDLQHWFSKLDILTIRIEEQNAAWYESSPLPVGVRDLFDHPDLFKATIKRRKIHNWGQLQAKTYEALCENQNHNIKTLQILDLSRECDALDDPKFHKFLERIRTVGISHVLACRKRHGSAHYFETTRYLSRRFIDHLPSVQHLKLKGPVYGAWSYEGLPYDWTKEATLPLKVTQMPQLKSINLSRTLVSQEMISFFVSHQDTLEHITLQNCYAYTPTQRTVSGRILGEGCSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXS4</accession>
    <name>A0A6A6QXS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_526002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXS4"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2496942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="187" mass="20388" checksum="663F7475799F963D" modified="2020-06-17" version="1">MASRFSSTTQHRDARSALFSTYDRSTSPSKSKSKSPAGRPTSGYGYGFPPPAASNGSPAFSAYPGGGGGSPNLSPGMVNYRPATPNSRGQYSDAVLSELESQNEDQLAGMSAKVRMLKDITVAIGDEIRDSTALAEKMNDSFDNTRVRLRGTMNRMLRMAEKTGVGWKVWLGFFAAVIFLFWYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXU2</accession>
    <name>A0A6A6QXU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_458611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXU2"/>
    <dbReference type="OrthoDB" id="3220769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="392" mass="43711" checksum="8ECB415604DCE937" modified="2020-06-17" version="1">MDVWRVSAEGNRTVLPSLTYYNNVIENCAVGSIEVDLEALDRTANQLAYGEYGAVIRAYISCTIESADGQTHFNLTTTYDYVTKAASLSGLYHFLASNFLDRDKEKRSSLYWGESLMSMYWAYTTKLMQNIRQNATANDEAGIRKGTISFTPNNGSTSDITSPDYFKVDYRFVIDVGLGSFGILWPGLYNWTTSVAYLDSIHAKPNIWIQADSLAKSAYSTILTDLGQTSYQPNILTNGDTLQYFTSNFSVAMQNYANAQPGPVTQDFKTLKATTGPLGATPSVISTNYICQIPKLKSAGNIFVSVLVADLVFLQALWKIFTLITDWLLFRKHPDRNQCQGCANHTSESRAESLPENGTMDYEHIELSTLDGPKRRSSYHSRQTSSQQLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY55</accession>
    <name>A0A6A6QY55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_457660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY55"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35249" checksum="370EA30DE7594F89" modified="2020-06-17" version="1">MESVRWFLGSKRKAEDAERSTSSSTSSTSGKRRKSFPSGIKLLHASENSVVDIIFVHGLTGDREKTWTAKGAASPWPHTLLAAKVPNTRILTFGYDAYVSDWKGMVSKNRIGNHAMNLLSADTRPIIFVCHSLGGLVCEDALVQAGQRPEDHLRSILHSTHGIVFLGTPHHGSGLAQWAEQIARSIGVLKQTNPEIIAVLKRDSEVLARIQDGFHTMIRSRSKEGLRPIEITCFYEELPLPSIGEVVPRHSAILPGYIPIGIRSNHMDMTKFESEDDPGFTAVAGELSRWAKDVAWHADATSTTAALSHQQDQQRSISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYE9</accession>
    <name>A0A6A6QYE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_616104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYE9"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025667885" evidence="3">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="357" mass="38434" checksum="7F66937B4223EFDF" modified="2020-06-17" version="1">MRVNSRLAAFLAASTSLLSVSAGPLLAKRASSTTESSTAPSVALAVSTLNDGTPTTFEAALPTSADSSESAEATAAVTTTAEETQTPTSAVASSTVSPINPSHDFPVCHDTSAAPFCLPNNESSLYVGNTYYITWNPDYFPINSTITIKLNYANMTQEQAWSSDTVDNSWGVTTITMDKAWMQGYSEYNLTFYALMFESDKPEQTSVPYDGPTITLMDKPAYHYTPPEHTKAPNKLGLMIGLPVSLGFVALVVIGLCIGMRKHRSIGIGNIMGRRAGYGAGKSRRQRMGLGKKGAIKLEERDLSGVPQYQDEVASPPPTRPRGHFREDSLGSLVSEDGIRPAGNAFRQEMDRQKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYK2</accession>
    <name>A0A6A6QYK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_525174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="161"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="35382" checksum="5B50A66EE5B60134" modified="2020-06-17" version="1">MASNYTCSACLSALVKRTKVVAPARRAPHKPSHLLPNTSLRAFASEIQLPRKSNSKPTSGAPAESDKVIEGAESITAPPKVASPGKSPLPASTTARLASELRKRASGTTETYIAYGATQPLFLECSRAGNYTVPQIDEGGVAPKNDAGEDLGVGTGWWYDSLGLTPTFNTWAQVTFLHMYLLTVRFRLFPKAHAPAWHQHLLDHFFHNAEDRMETYHGMVARGVRNKYLKDLWIQWRGVLAAYDEGLVKGDAVLAAAVWRNVFKADPAADVKAIAEIVSWMRREVRRLGEASDAEIAAGWTFKGDPGEEAPAVELKSKLMKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QYZ7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_320971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025570214" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="435"/>
        </location>
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            <end position="195"/>
        </location>
    </feature>
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            <end position="391"/>
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        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2497675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="50615" checksum="5B77FBED2C3C7D00" modified="2020-06-17" version="1">MYGSIKPVSALVLAFVFVPRALAADALFQSYCSSDNTGSDSDAKYWTWQSNGWCHDQCVSSYAFAVVQGNNCWCSNYVPADTTSVDDCNVNCPGFPAEQCGNAADGLFGYIALNNKPSGTLGAAVSTSSSTSAMVSTSQLTTAVPSSAAISTPTPEVGAPSLPTSTSPISSSPSKTQASSFSQQPSKPAHKSSSPSTLLIIRSTSVVIVSSFVVLSTYLTIPFVSSSTPPSSSSPQSHDDPETVFRTVTETPSQVVSSTFISSSSSSSSSQKTSAAPLTTTTQAPSRTTTSSATSWTPTPVTSVQIVTVSGSVVTKTVTGMSTQPAEIVQKKHSTSGGAIAGAVIGSLAFLALVGAFLFWFFFWRKRQSDKTKDSEAAGNPPQRNTSTMSRTGLLGKSEKPSYPPVITNLKRSSTQALDQSASISPASDRRNSRPLFYDQRLNPSALMDLDNGSHTSILTIEDNRDYTRTLNVRNPDPSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZM0</accession>
    <name>A0A6A6QZM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_571348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="17763" checksum="AAD4BEC2F4813300" modified="2020-06-17" version="1">MASPTVAICKFVGTISLGLLTGVSASLTSLTLPSLFNLPSAVNARDALTYLSTRTRTVTAYLRNTALISLFAAYALSPRSSRHPYLFYTSLLALASGSGVDLALAAQDKRAGGSRSRASIADLNVETPEDLNGEQVRQAVEGMRYTEGVRTAVSGIAFAMGVVGIWGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZN0</accession>
    <name>A0A6A6QZN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease-like protein</fullName>
        </submittedName>
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    <gene>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Bloem J."/>
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</entry>
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        <source>
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        </source>
    </evidence>
    <sequence length="594" mass="66939" checksum="DFD45723D8D51842" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_333636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2B8"/>
    <dbReference type="OrthoDB" id="3518533at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7907" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="203" mass="22365" checksum="86212A38FC5F05E7" modified="2020-06-17" version="1">MSPSIITSNMASPTPSSHRYYFLKTRSRTGAAKYDSLYIRLHGNGVDDVVLTAAPPVFLRAYDELATSAASTEPRGGTAVKFISTKSGDRQWSLALGRPREFVGWEPVQIVAAAEDDGEREGEAGARWVQKEGPSQEYEALEWDVGSSEGDGKGVWKGWMVCEWVHGHPQLFWVTGMLDSRGKELDLPGFCERVELVREGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2H5</accession>
    <name>A0A6A6R2H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_548293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2H5"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="552"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114176" checksum="AD8116BF87779A41" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2W5</accession>
    <name>A0A6A6R2W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_604320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2W5"/>
    <dbReference type="OrthoDB" id="10610359at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="268" mass="28956" checksum="45F066F46EF72B77" modified="2020-06-17" version="1">MSVPLQTLHNSAPGAQSGGNNGAQTAGNSNTGFVQSSQPPVNTTIGSQSQSTTNSTASASNVTTTPSGKKSLLRWWSHPNTCVRIGGYVAIFGLLLTIVAFGRTEYFSQRQDVYGATQIDLTKKADRIQTWKDCNDKSLVSVRAEQDPSAKANNVKGIMKNSTICAPYRGLSYDDAVKGGIPSISKRALFYNATSTAVASMDSWLSERAFLYKYGARHWIGLTLQECWSQLGIQRQYLATSLIAVIIIRAVKQSINQPGPSRLIELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3Z8</accession>
    <name>A0A6A6R3Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_453914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3Z8"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEHYDRATASE (PRPD), PUTATIVE-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2499054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="476" mass="50852" checksum="6F2FCBD2EEA1873E" modified="2020-06-17" version="1">MAAQASDYDRVLQDTLDYIHHAPITSASAYDLARLSLLDALGTAIANLSSPDPTYRRLVGPMVPGTTVLCGFRLPGTSFELDPVKGAFDLGALITHPHGSTSGPPTTTPGHPSSTLGALLATADWLSRTRTRPAPASPEPPTGVSLRTLLTVQIEAYELYGCLAAHNPTLSPALLANVAATACVSHLLELSEEDALAALSNAWADAGALRVPGSGRKSWEVADAGARAVQHALLAQRGQPGVPMVLGAEGWGVQDAVLGGMDVRLPGVYGSLEKNAYFQLVPAAWWAVSAVEAAVGLVGMLLEMGLSVEKDVQNVVLRTTRAGKRSCGGGSGVGRRGDLGYVVAVVLLLEGEMVEEEDYEDDSAWARDPRVEALRGRMIVVEDEEFTRGYDDERTRSAANGIKLLLGVDAEVPEKVVEFPVGHPKREDTALMVGEKFRKNMQKGDFGDDRVDEMLEMVEVDDIEVADFVDLFWKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4H9</accession>
    <name>A0A6A6R4H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_536830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="47330at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="13235" checksum="DCDE1AC0D15330EA" modified="2020-06-17" version="1">MSLLRSSRSASLPALEVKTAPHHWVGHCHLTAKQTEVCEHIAKEKYDWAFGARVLGDAVADIKSNLCISYTGLGPDEEIFEGTNGGPLQRFEVQLRPKEEGSSEIVVLPKGQIVLPVEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4U8</accession>
    <name>A0A6A6R4U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="438641at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="104351" checksum="91C04AD1DF1E7B84" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4X0</accession>
    <name>A0A6A6R4X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_504855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="531" mass="57049" checksum="341C0F43FB780F94" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4X5</accession>
    <name>A0A6A6R4X5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_524261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4X5"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025695455" evidence="3">
        <location>
            <begin position="31"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="408" mass="40247" checksum="3A91C9D37A3F033C" modified="2020-06-17" version="1">MRLSKGPGLGPLAALLSVLLVLLSASAVQAADTGLPNLSTVAAPSGKGASSTQASSAASTSASAAAKTTVGSSAASSAAASTGSVETFQVTSGPAISTTTSLSVFHLTGLPTIAGAGIPTVIVPDLSKASFMQKSNLPDGTVFICVGAALGFMGMAILAWRGLVAWSLHRSVKRAAMNQHLAITETKGAYANAGSGNRKSKSFYAAVGASSTMSLDRLSAAPPPHSKPPRPFSSVNTSGTPPKPTPSSSLFFSPTAGAGLHSAANRSSSYLPAGYYASGAAQPAAGGQTTHVGGAGGPPSSLLSMGPTAAGYSRARSVGISPPGSPSLPPSRGNPYDRPPGSRGESVGYARSSVAGTLGGGVYGHGGLSTSNLSLNLPGGTQVPGGRAPSAYLEDLFENHGNGPRERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5Z6</accession>
    <name>A0A6A6R5Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">BU16DRAFT_534631</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2499991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
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        </location>
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        <location>
            <position position="1748"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="1749"/>
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        <ligand>
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        <ligand>
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        </location>
        <ligand>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R646</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499680.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="290" mass="31954" checksum="117F6D17CD92141A" modified="2020-06-17" version="1">MPSFDERNAYVKKEGDVFFDDGREVELLHFIHNKPDIDEIRGSPQRVLQAIDEFARTKKYLMNVGEAKGKIVTDLIEEAKPETMVELGGYCGYSCILFGDAVRRSGSSGSRYISLERNPEFAAVIMCLVALAGLSDTVKVVVGSSDASISRLHASGELKHIDLMFLDHYKPAYTTDLKLCEELKLITPGSVLAADNVITPGNPPYLEYVRSSVAEKREAAKQGPVVGDGVDPRFPGRTAQQYAKRLGQAELEHTSKGNPNLVYESRINHSFEPTGEPDGVEITRCTGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R745</accession>
    <name>A0A6A6R745_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_523097</name>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="79252at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="181" mass="20384" checksum="AB3FD858D9DC51DF" modified="2020-06-17" version="1">MGVNHRAISQPPTLFHRPPVAMAASTINQYSMQHGVAGSPSTHQLAMQHDSTTPQTSIQRPEQMIGVTSLGPDSDPRQHTPSQPNIVRTPSQRLSPRVEEWTEQLRILYAKRLQIGGLCRAIARGDSTPRNYAQLKIAKREYVDKRDELLGYNCTEMTRSIDKDFPLPSKKPVETDWVDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R861</accession>
    <name>A0A6A6R861_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative SNF2 family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_454571</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
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    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="344"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="950" mass="105591" checksum="533453655F0D2F17" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R875</accession>
    <name>A0A6A6R875_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_255118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R875"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="208" mass="23429" checksum="C0E1CBBAEBCC1DC5" modified="2020-06-17" version="1">MLTRPLSLPSPHFVESCGALPFHLPTRTIALVYYKRKDEYLLAKGRRNISESRSAAALREVREETGLTCTLLPVTMETRAPPADEKAEETNAGDRVRVEEECVEPFMMSMREVGRQGKKGQQGSRHLKIIWWFLGEIVEGEGQASGESFDEGRWDGPEEQFDVVRVGVEEAVEKLSFEGDREVLRKGVELVKGTYWSKEGDSREGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8A5</accession>
    <name>A0A6A6R8A5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8A5"/>
    <dbReference type="OrthoDB" id="3692147at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="35250" checksum="E72AA0662E3384DC" modified="2020-06-17" version="1">MASKMSQHEAYLHNYNESRLCQLPPELLIKIGDHLSPVSMIAFRQTCQQMRKTCDLGRGTFPLNECNYTEMSALETGFFRRSLPTRLWCSLCGTRHPTHCFLEEQRQAPPLARRCPEVRLCQHRSFTRPELKALLWMKRIPGLLPGLPNLLFRCSHHSPKFDGDHQQMCGASIFNNQDTWDREDSFCLRMHYFLAMIPESLTGATADKATVKAYHAKISAALNAIALPACHHLRVNDPTILAYALLPRPHRADHEISRLVHCKAGESCIDSPCGIHVTYSLSWGERPTLYTGLKTYRHWSPEDSAEAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8G7</accession>
    <name>A0A6A6R8G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_614563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8G7"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="14"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2500871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="511" mass="56248" checksum="49B2B021DA0CE8B0" modified="2020-06-17" version="1">MPSLFFKNRRVYLLTSVAYMGSLLFGYDTGVMGSVLALKAFKKDFGLPTESTGFANARNAYVSSNVVSLLTAGCFFGAIAAAFLNERFGRRYSLMGFALVFLVGASVQTAAHHHLGMIYGGRVIAGLGIGGMSSITPVYVSENCPPKVRGRIAGLFQEFLVVGSTFAYWLDYGVSLHIPVSTRQWRIPVAIQLIPGGFMLIGLCFLKESPRWLMKQGRHDEAAASLAHIRCEEPGSEEVVKELAEIRAAIEEELNATEGVTWKECLLPGNRYRFLTGFCLMFWQQFSGTNSIGYYAPQIFQTVGVSKSSASLFATGVYGTVKVVTTGLFLILGIDRFGRRKSLLAGAAWMATMMFIIGAVLATHPPVVKSDTVSSASIAMVVMIYLYVIGYSASWGPVPWVYLSEIFPTRLRAYGVGMGAATQWLFNFVITKITPEAVNHIGWRTFLMFGIFCVSMGIFAFFFIKETRRLKLEDMDILFGRVTAEQRAEDVERTLAVEKKGAIHLEEAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8J5</accession>
    <name>A0A6A6R8J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_238841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8J5"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025718072" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="381"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2500180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="536" mass="56309" checksum="894DB6C860AED135" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R955</accession>
    <name>A0A6A6R955_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_613105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R955"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF32">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="57"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="388" mass="43630" checksum="89256BEE703C6CF1" modified="2020-06-17" version="1">MKFASPDMSKIYQNAERDDIDLRSLHFLDEALVSIKELSNPAVRNQDLPDFSHCTRIDTHTHPVPDWYRKLSPLAAGRDTPSWSPSAHLKFMHENDITRSIICISTPQANLFPDDETRTVALARLLNEFCFEVVRCYPDRFSFLAVVPLPYTDRAVKEAKYALEELGAVGVGVMTNHDGLYPGDQRFAGFWSYLGRRDPIDGCQKREIVFVHPTDPVIRVDGAQKIPISSSGGKLVSSNPAPFRSGLGEFYFETARAISSLTASTTIHDNPSLHFRISHGAGAFPCIADRFLLGFPELEKNARKMYSERFWYDSAGPVYPHQIKGLLAYDIGVGQMVFGTDYPYGIGFWDVKANINGLANADFLNNEEKEAVFHENAEALWKGKIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB47</accession>
    <name>A0A6A6RB47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_535249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB47"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2500687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="376" mass="41600" checksum="9BE80DE3A7FB1E74" modified="2020-06-17" version="1">MATQSRAVAILVGNIVPQVFATLFSLARVYSRAYILRTWAIDDWLIVFSWFCGLACTILSCVATKYGAGHHQANVSIAAAQINIKIGFITLFFYHSVLASTKISICLFYLRIFHPERRSRYLIYACIATLVITFIAFTFFNIFQCSPIAAYWDFGLKAAGGHCTDPIPAFYAAGIYNILSEVFLIAIILPRVLVLKITRRQKTALVTVVSVGWLVAIASIIRVVRISKLLHEEDKTWASYDTTIWTAVEIDVGIVCACAPAIKPLLNQLIPRFMGTLTPNSSGWNRYGRKGTYDHRLSTRKGNVLGSGIEMGSKRVQRITSETDLTGHGKNEFSEVRIKGGAESTDAESLEEVRGGDDGTIMRTTSVLVTTGYDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCU6</accession>
    <name>A0A6A6RCU6_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_576568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <begin position="1"/>
            <end position="33"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="414" mass="44681" checksum="EDDCDC4935A6FA58" modified="2020-06-17" version="1">MSAPTTLPASPHNAFRDREATGTPNKCPARRTLGELTPKALNAAKTNNTAVEQLETLKNRSPLKQVQTLSPARQMDTENMSELHYPGFGRKRPITEVDGAVAREESSGYTYRPFDERDGSIQQAFRPSVIARMREDPSTYLVSFEGDDSEEIVPEPEAPVSQETNVSFSSLVNYNPDGSSSQARVSPPPQEVPEPSPPVNTSNTAAPTERKQRAEALRLRLRMAMYKVQTNQTEIPLANLKLPASSATTKPLSANSPKPSTLTTETSISTTDSSLTSTSTVPSITFSRALSSPAAKPPTKLQLLPAPILLPTAYSSRFITEAGIFPSSPPGSISPSQTHIHPPDLSPSHSFVTPIAQRRAFEQLSSPPGSAERVGGVNTGLRLNRRFEEGELTSSVVKGRAASGLIELMNSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD07</accession>
    <name>A0A6A6RD07_9PEZI</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_611952</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Lipzen A."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="755" mass="81624" checksum="CE851027E749A525" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD37</accession>
    <name>A0A6A6RD37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
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    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFS0"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="46"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type B" evidence="18">
        <location>
            <begin position="836"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="486"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="766"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="868"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
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        <location>
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        </location>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502590.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114068" checksum="F93E804107FA87B7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFS3</accession>
    <name>A0A6A6RFS3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q883_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">HET-domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 269.34</strain>
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    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAC7"/>
    <dbReference type="OrthoDB" id="4192220at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="497" mass="55068" checksum="6A2D2E61BC59E57C" modified="2020-06-17" version="1">MARSGDALNSIDGSSALVMATPVFELPNELMLEIFDEVRRTSTTPNSDLLSCMRCCHDWNDLIINILYEHVSLLYRLKAVSAVPLFLKSSKYDQTTSLNLTIHPTLLSGFRIEHKNAFKSLDGLLNVLPGMKRLETFSLTMDSELDRTQFQHIPGSVISKLVLALPASVVNLELDSRGAEANRHGSGSAQTTSHDICDAVAQLFPRLHTLALGLDHICEMILGAFNDAIGGTETSGKPIKTSNQTTIFPLRHALLYPYRNYPSGTPPPRSYCPADVLAKKASSFCHLHQFPHLQSFIVIQRQLAEYTPHPDRDLFWHMWIIRNLISNTTSLIPYNEVNVTGCNPLFTVRDTSGNDHLLSRSDLHTAMAGGQCPWTTGHSGVRVPPEFGNTAQRAKIGVEARVPHGAIRRISDLDLGNGKKIRLRAALDRETAEAEVGASMGTWEWEATTRCPLLKAHCTPGLMDKVRCLAVTLPPGWEWQWDQHADDGPKRKPVFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAW1</accession>
    <name>A0A6A6QAW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAW1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="158"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="37648" checksum="1E5F50ED6668A86F" modified="2020-06-17" version="1">MASISSKLMPPLFRKHGEPQLPLSREEGEKLLSLALGFKFNRLGPTRGGKAYSRHDREAFAERHPTIPKNAVLVSVDFESLSWLPSLHPLYGKITEVESAFFDCRKADEHQSWEWVGEDVTAKHYIVGEYAHIRLISMTGVVIHYTPPTSLPTARSTTPAPETKYRTIILIAHAFENEDNYLRHQLEISYSDVDVYAVIDTQILLCGKRQRPPGLRELLVNRYGIMPETLHNGANDAVYTVAMVLFHAVDKEDNWKLTPTRWLANLKMRIEKEAGVGAAKNDLEKALEKLTVEGPTIQTIERTAHAPDTDPAKDAERIRAARLARLGGGAAQKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBR7</accession>
    <name>A0A6A6QBR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_183215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBR7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18407" checksum="0284529B5BF559C8" modified="2020-06-17" version="1">MPIPSHPIVHETCCWWSCCCFVERVMHTIAAAPRIGARASNNRRQTRGCWSASQASTQLANVSEVLCTSSSLSLVLASRRVGAVDAGFYLVGNGMHAKRQLGVWRGVIGGGCGDSSEGFCGSCGSWGRERGRKAKEANGECRRNGGSEVCEGELGAMGKGAFLCKRAGRGAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCG1</accession>
    <name>A0A6A6QCG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_165247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCG1"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="392" mass="43024" checksum="3FB3063836B44860" modified="2020-06-17" version="1">MCRFLVYKGKDEILLSKLILDPSHSILTQSYDSRLRLDRRRPHNGDGFGVGYYTSPALGPEPCIFTSTIPAWNCINLSRLASKTTSSLIFAHVRATTEGNLSDSNCHPFRYRSLMFMHNGGIGGWKHVKRRLAVSLSEQWFVNVQGSTDSEWAFALFLDSMERAGVSPDDERAASEGFGHIVLRKALLKTIERINAFIAEIPEALRTEDTRSLLNFAVTDGHSVVCTRYVSSCTDEAASLFFSSGTSWLEDLPASSPSASPSPPPSDPPAKTFRMARLDKSSSTILISSEPLTFDRDNWVTVPTNSVLTIHDQTLMIHPVRDQFYSANPAHERSAKFAETKGQMVTGPDKSVLIGEVGNKAQNGQLSPGRAGGCGDAKVDVVSGAIRRLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD42</accession>
    <name>A0A6A6QD42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_586086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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</entry>
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</entry>
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        <source>
            <dbReference type="EMBL" id="KAF2490311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="106" mass="11703" checksum="B143731EAA33FC7A" modified="2020-06-17" version="1">MASISSSRRYTPPALMKNAHHHWSLTVICIISWAHNTSQPYIHPVSVLNHHTMETPSSLLTPCHQILQSHKTMGRNLARYLEPHRGAVFAALIAAGGVRGEVHIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE58</accession>
    <name>A0A6A6QE58_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="142" mass="15900" checksum="E85CA3E3ABB1EFC7" modified="2020-06-17" version="1">MPLGKDTKMAVSPRRNLPKVKQPMSEPNKAAREGNLPKVKQPMSETDPSTIRRTSPLRTRVPMAKPVRPGPIVAAVEDRRAGPLFGSSCATRRKRRTTDWLGAGKHQTRTRKIYCSTRLSGMQGGKRRRRMESRRLVLGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEJ2</accession>
    <name>A0A6A6QEJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_530928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5578329at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13438" checksum="615B8A3646D61208" modified="2020-06-17" version="1">MSSNILADRDTNAKLAQSPEKEAGKDKPKSMEFHRQVLESRMKSGQAQQTYISPSDQILSPATQKVNAYRNKHAMKKSKPQTLFAKTSSKNLEAAKSASMSNMFEDIPKDNATSDATSEDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFC3</accession>
    <name>A0A6A6QFC3_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_530341</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2327445at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="34192" checksum="1B009D2C33B5451D" modified="2020-06-17" version="1">MFGRKKHDCPGSLPSSDAHLSTQQVHRATRTRKIFSILTSVFLFISVIFVIMVEVGQTYNRSVLRDIYFIKLDLSHIIPAAVPNSVLINSIARTLGLHDFYSVGLWGYCEGYNGEGATNCSPPKMLYWFNPVEILQSELLAGASINLPADLNNILKLIRIVSNVMFGFYLAGACLSTVLIFIVPLSIYSRWASFAIAFFTFLAALFTTVATVIATVMFIIFRNVIKGVAEINLKASIGINMFALMWVAAAFSIFAWLIQTGLCCCCASRRDVKTGRKKGNKHAYTDTPPSETEKPKARRRFGFGKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFG5</accession>
    <name>A0A6A6QFG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_574823</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFG5"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="89"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="355" mass="40266" checksum="94E8AE56F46C81F7" modified="2020-06-17" version="1">MPRLDHSLESRKYYDSSRRNALGLGGLQITSFRKIARKSISSIQSLQSLSLSKKKKPSRSKPKKSRDKPTPSQTRPLPTNISDLPPSSKQPQSPLFRLTPELRQQIYRHVLGTSNIHLTLRHGGQLLRHTRCKCPSCPGTVKYRDRVHPAWTLDWQCDSATYDYGGALASPQLLRTCRAVYAEAIEFLYSANVFSFRSQKTLARFLADVAPEKLALVRVVHLDVVPCQNATSLGYHHEMECAFSAIRVAARLPGLRELEVRAHAAEKSVQPAGVGYHREDTLPYQLLAVRKRVFERGGLEGATRLKVYLPPGVDAMVKWMREEGSYEVEELEEWEWSKGRDLYQWKVESEPGGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHY8</accession>
    <name>A0A6A6QHY8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_446103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHY8"/>
    <dbReference type="OrthoDB" id="2350934at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF24">
        <property type="entry name" value="MYB DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="108" mass="12943" checksum="0AD0D342945A1898" modified="2020-06-17" version="1" fragment="single">KRQSKWGQEEDNLIIELRGTGMKWEDIAKHFPGRSAIACRLRYQNYLEKRAVWDEEKKNKLARLYARFKDQMWQKVASEMQIPWRSAESMHWQLGEQEMSARANAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIE0</accession>
    <name>A0A6A6QIE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase,short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_118904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="285" mass="30040" checksum="34CF72FBBDCDFE8B" modified="2020-06-17" version="1">MAPLVWLIIGSSSGFGQEIAVQALKRGDKVIAAARSVSKLEVLKEAGAEVIALDVTSDATLLKETASTAHGFYGKIDILVNCAGYNAAGAVEECSPDEVLASFNTNVFGPMAVTRAIIPYMRAQKSGTIANFSSTMAWTGAGGQALYSGVKAATSAISECLAAELKPWNISVISIEPGSFRTDFLAGGHLTLPKAPLKEYDETPARQVIEYMGYINGKQLGDVVKGTRVVVDVLTKSGSAVGREIPVRLALGPDAYDTIKGKCEQIMVLLDEWKGISTATNHADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ08</accession>
    <name>A0A6A6QJ08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_593984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ08"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="22968" checksum="E0D65C85A92D7BEF" modified="2020-06-17" version="1">MSNRNTSSPSGASSNDAASSGPYNARLRTAAAPLGAGQIDLSSVPLDPRIPRGPAPGVAQGAPPAMTQDNSFPGASNPDGISKNNQGPAQGLFQAPRVNSSSHGNATAGPSNSARSDPKPARQLAAPVVPSMMAASAIASAAHQSGLTTAPREWEDPANTQLVFMPWGQAVMVYAPPPRPLTPGQTMPRAPEEEKESNEKMEVEYLLSLAEGRDYEEETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJA2</accession>
    <name>A0A6A6QJA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJA2"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="400"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="481"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="778" mass="85750" checksum="D2ACBDEE088A8D2C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJD3</accession>
    <name>A0A6A6QJD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Translation factor GUF1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_110541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJD3"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2492332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="663" mass="73759" checksum="9BB1DACC8FC771D5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK28</accession>
    <name>A0A6A6QK28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_467943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2492376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK28"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="34816" checksum="F3DA61280364F12A" modified="2020-06-17" version="1">MVRVAIAGGTGGLGRAVVEEILATKKHDVFLISRTEAFKDDPNVKVLAIDYDSPEAIASVLKSNNIDTIISTLGIFQEAQQKAQLNLVEGAVQSGTVKRFAPSEFGLDYVQNKKDGVAIPSEAMRDLKTGTVDKLEASPLTYTRFVCGFFLDYFGYPHYPTYLPYMGIILDIANGVAAIPGDGEQPVTFTLTRDVGKFVAESLSLESWEPTSYIVGDKVKLNDMLKWAEGATGKKFDVHYDDVAKLKTYQVTELPSNVPRYAFFPKEMMFGMLAMMGLGMAEGHFDFKGPTLNEKLPQVKTTKVKDFLEEYWTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL72</accession>
    <name>A0A6A6QL72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_564305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL72"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="350" mass="39326" checksum="6AA82E89BBB7673D" modified="2020-06-17" version="1">MSYRNRNNRQQYQGASSTFREHDTAYNDDGYYDDNSYDDAGYAFKDAAGHGSSAEHHKQPDEYNQGPTPDQLDKAEWVHDRWQGDDDDRPYRKNDRQAFKPLDSYQPARGPKTTPGVQVTIRGFPHDVSEPEVRDLAEKFGDALEVKLIFDRMDRSTGVAHITYKDEDTARAAVTDIHGAKAYGKPVTATITARNFAQKRSLFERIEHPMAQDRDTSRGRMNNRTERGYAAGPRNDTRRDSSNRAYNNSRRSSEDKGARGGRGRPAMDRYIPPHRESGVLRPRAGGNRVERKPAAQGRRGGRAERPKLTQEQLDKEMDAYFASKDAGAAAAAETAPAAAKADDMDLDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL94</accession>
    <name>A0A6A6QL94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_594085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL94"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025533395" evidence="1">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="32297" checksum="72523DE96E71218C" modified="2020-06-17" version="1">MFLEHLFLALTGALFLSTALVSAQRPSSTPICDYYAETILGANTEANQRLLMVLLLHTTVLGNYTTPNTGIAVHGIAAPGTFRGQKVNLIKYFTGEIASTNNGTTPHGVPILLLDGGGAAPLLKNVSSYNTSSLQYHIFDHIEQYFGTLLGCSKQGGSALPAYQGRASMYEVHKFMDLSAAEMGWFNLQATLAIASLGFSKQDVGIVNDTLYNVFSQRCSPAVSLVPKNAGPQLQSLCINEDCPLDKNATCALYPNKGVGVAPEVVNATNASASGTGTVTGTAAVATSTGAVFPSRTVTAASIIKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMC8</accession>
    <name>A0A6A6QMC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_620204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="377" mass="41161" checksum="4A40624CC61E70DE" modified="2020-06-17" version="1">MSRPQLETSRSHTPEGPAPEASLFSLQLEENVDGVLPPAPTPPKAVPNAVTRPDFRASRNKYYVDHVPPSPRARGLPSPWPEGHPLARKPLRAIPGLAPRAPLRDLQPAEKEGVPLRAHTPPRAVPNAAPRAPPSQPPVTNDTLVEIPGPNLHRFLVDPTFTDISLHYGPHSTPAHKIILCSQSQWFAHALEPNSSLTTLRLEGYWSWSIRALLSFLYARSYTPIYHALIAHTAAHAPVMAPPEWHARVYHTALHFAVPGLITHAVANFRAACAHIMARARRARVRGEEEVGVDGVVKGVGFVYTLPSSQPTTHDELRKACVEVVMEGFSRLAKEREFGELVAGNEALGRDLKAAFREEGVDMAVVRGKGSGGLRMG</sequence>
</entry>
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    <name>A0A6A6QNH4_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10639882at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="242" mass="27926" checksum="CC9429232EE6D9C2" modified="2020-06-17" version="1">MSNRNAKGSRPRAVDENVRSIRNVFDDYSMVSLRAEEKFSAEQKIRLLEDEAERQLVLLEGLREKIDSSDSTSSRIGAANDKLSQMISDARVKAVTEAKDSRIDDLEREREYHKGQLQALTEDETFDTQAEGAQASEVIRRLRHQRDQARNRAAARLESLKRWHEVGREAGLELRRREKMVQTQNQEIEDLVRTIELLGGETALIRKTMAMDPVKDDDPEWLQEDLSFWDPGAEFEDEPVEE</sequence>
</entry>
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    <name>A0A6A6QNQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24648" checksum="650A61C943EF28B3" modified="2020-06-17" version="1">MSLRETTTLAHTAQCKLHMAINRPDRKDRDWRFVLGHAVVLDNLMLRLVEIEEGIEKGDHSSDVKFKGAGGVKSAHHKPSPLAAEKRARRSPPPQRIDESSSEDEAVEEDDDDDGLGLMRFPSGSARPPQEPALVPSDDDSSSSDEDLDDLLQPVFNDPDQEVLKKVTGEKGNEEMAQLYNDVSGCPCHGKRDDAPVVKNFWELPLEGNVEMGGKRMGVVEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNR0</accession>
    <name>A0A6A6QNR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_61800</name>
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    <organism evidence="4 5">
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5429634at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="127"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="483" mass="53160" checksum="7972039AACCF53F3" modified="2020-06-17" version="1">MAGAYSYDSLPPLYESQDLADGREYSLDLASTLYSPDPRQSGSDSPLSKNVDVKDGASIHSTSTGYSTSSSSFEKLKHGLGLKSLRRKAVGSWRLSKTKRACETEYVRVGKGWWQDQLLSDRSIRGMAALTAMFAIAMIVIMATNAGAFRNRPNRNSTSVGGNEQSCKSVQRTNSALLIIINIAATMVLGMSNTYQQMVTSLKVGDIKYVLSKYGDTRVGTNSPFAINHKREGKLNAWLAWLLLICTSLPVHFLANSLIGPSLVFTPPKAVEYNATTITGYRSYSYSDNSITAENSFLCWSALRTGISRFPADSYGRLGLFDQMDDSSYYSSSATNYGRIVVAYDKGNCSSLVNNTNVIQAQSEYNRTLEYTQFEVGSCLLGTNVFCDLHEPSTGACRLNIRMQAAFILGGCLVIKAIYMIAVNLIARGKVKRQCLTFGDVIVASASDPELRVKDECMVNAAESYRRYILPQHYSPAQNWTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPC2</accession>
    <name>A0A6A6QPC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Bloem J."/>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="214" mass="24801" checksum="1486A9FD36E3DE9D" modified="2020-06-17" version="1" fragment="single">ELPVTMVPVLRRASRIAARPYRQTPLDFVDDLKPSWALNVQTFMKMPVGPSERPIQRIGDTWLPWLTWTERTCLCLATMVYSAIHLSGWNFHFPTRTEQILWRVSSLILLGATSVFWLLKCPAIIWRHHGGQELFVRFFTRKSNPPASQQKCLHETPFEPRELPLVWEFWGIFPVAFIYALARFYIVVESILSLRSLPLTAYLTVDGSSFIPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS85</accession>
    <name>A0A6A6QS85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_550743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS85"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="644" mass="72531" checksum="81EB6C228ACAAE45" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSJ0</accession>
    <name>A0A6A6QSJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_573078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSJ0"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="43894" checksum="058C9D8441848581" modified="2020-06-17" version="1">MSLRMYGGSGNPQLYTMVTTRTLNVLYGVSNLCALIKNFKLDGVARMNAGFEVMLCDLVVAGVTQLEEDPTLPQNPKRVPPFGFGNDFAPQNSWEWIRSGTWYYGTSATDAGSTRETRIQLDLCGFMSLLRPMPQQFEWTSPWGVRGNDTYQNGWGLRRGHRLLGISREDISTMKKWLKPITTAHALTETITNQHRSRAREISVALRNGPQDSDSIQPIIKTIHELSYAILYTYLQYPSAAKISSQEARNLTIARCSSVYTENIKPSSLNEFEVIIKESIRIVMAELCSWEWHLFEWSEKHTTNLIDPENELELCYIPMWPVIHAPGKHQGGFYADDSYTEEEMYDFWRPWCLNRTLFDRGGGRAREPAHQIPDAPNNLPVLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT48</accession>
    <name>A0A6A6QT48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_510143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT48"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="740" mass="84112" checksum="744D2F8CD73AAE0D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTS6</accession>
    <name>A0A6A6QTS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527383</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2495636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="112" mass="12538" checksum="8E923FBEDEFE65B8" modified="2020-06-17" version="1">MAYSVWLVSYLGYPRDHHGIFVETGPDQTGFLFQPAKKPENSTTYVPDSKTYLGTVSEANYARIQPVVETFPPPPKQFHGGKKIDLAAPIRRCQEWTADAIQGLRDQGVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTX8</accession>
    <name>A0A6A6QTX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="204" mass="22296" checksum="5B5CDD72D12E47DC" modified="2020-06-17" version="1">MTGLKSRLFSSISSIQPPNNPPSRNFSVRTSPKDANVTFVHHVGDPIEAPPLYSIVTLEGLKQSLLVYRGIPHPHPRSMIGNANFHSFPSTTDLNLRGEPIPMKMNQLSGNLSLEHYPFGKLRWKWKLDRYTGTGLELTTASGSKLAQLKSAGIHRLREKRLEVLVVCDERFVELVVLSAMAAKTISKAQVEVGSEVAGAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU11</accession>
    <name>A0A6A6QU11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="123" mass="14091" checksum="34746B2F64259722" modified="2020-06-17" version="1">MPSQRPLPSWSLLALALLFFSSSYAQKTKLWINQVPAYSNLPPRPIIILTAKQLYIKKTPQYGSSYRARVFSRELVIRFMDMMDEDLKQPMFGPDDSFGITFAPQATPCFFVTGERCSLFKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QU79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_560912</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="17735" checksum="71E9661D225DC64E" modified="2020-06-17" version="1">MAASSEPFYVRYYSGHSGRFGHEFLEFDFRALGDGRSASARYANNSNYRNDSLIRKEMCVSSLMIAEIKKIIKDSEIMKEDDTKWPQKNKDGRQELEIRLGNEHISFETAKIGSLVDVTESQDPEGLRVFYYLVQDLKALVFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUJ1</accession>
    <name>A0A6A6QUJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_357165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUJ1"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="520" mass="57554" checksum="00B7B9E1ADB61696" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUN8</accession>
    <name>A0A6A6QUN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_538510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUN8"/>
    <dbReference type="OrthoDB" id="3736456at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="43674" checksum="1DC01433E39EDBC9" modified="2020-06-17" version="1">MPKKQTVYRPSRLELLPLELREEIYSHLGLPIRHRYPVTCRSSDRDQDCEDPFHNGHFDPKNDRFIRSLLTSITFVDPGKGWEPGYGWGSAEFARVLETSSHERYEDGDTLHLSEYRAIGALVCTNKFIAADVYTLLFSKVEMIFNFQLSNKAVFNYHKGWPRGDFIPCEGEKKNGHYPPEGKTQVVPYRMQLSPFPFLFMTHVTLTGSLGRSFHEEIPHPYLMSRRQRRDKLAKKALSIRYVAQNCPQLESLTLSFSHYERDQGRLKKSYFEATQLALREVARMCDCLKTVKIQVFRKTTSTEHGVVSLLDRDDYQWTEKRFKTKGVPRWVLDDELAEWASGVLTEFWRYEGEVTEHYRQEQLRQARLGGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUV3</accession>
    <name>A0A6A6QUV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_459626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUV3"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2495922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="563" mass="61745" checksum="546415032045F027" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUX6</accession>
    <name>A0A6A6QUX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_608575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUX6"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="236" mass="25870" checksum="67A4BB5FA5D6D042" modified="2020-06-17" version="1">MNDERKSKYALHAACREGHGTYSNLSEQANPKLDSLRDEDDRLPLHWAVSYNHLPIVTMLVQRKNFDVDAQDGSGWTSLMMATSRKDAETIVDLLLKKDADVNMKTINGQTALHFAASKNNLDIARTLISHKASARVKDKRGQLALHRAAAAGSVPMMKLLLEAKSPLNATDMDGMTALHHAISEGHGDAALLLLQAGAETDKKDMDGHTAIELVPDAKTRKFILQAAEREGIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWH8</accession>
    <name>A0A6A6QWH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_460309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWH8"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025482599" description="agmatinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="44397" checksum="45CC1D2B398D3685" modified="2020-06-17" version="1">MRLLTSILAFSLPCTIIAHSTHHREHQETFSKDRLEELQKKWDTDWGFSGISTFAHLPYTRCLSHPETSFDIGIIGAPFDTAVSYRPGARFGPRAIRAGSSRQTSFRGFNPRAGLNPYTSWARIIDCGDIPVTPFDNALALRQMSEAFIELGERPPTPESLESSSTYQHKPKLLTLGGDHSIALPALRALKKIYNQPIAVVHFDAHLDTWHPAKYPSAWIDPDDESTPSFFNHGSMFWIAATEGLIANSSSVHAGLRTRLSGDDEADYSDDSQQGWVRIATDDIDDIGVKGVISKILDSVGTEVPVYLSIDIDVIDPGLAPGTGTPEPGGWTTRELIRILRGIESLNVIGADIVEVSPAYDGGTEATAMAAAQIGFEILTSIVRRGLMDQAKISKAGDEKRAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXB3</accession>
    <name>A0A6A6QXB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_396480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="396" mass="44793" checksum="E41C8CF0797AEC9D" modified="2020-06-17" version="1">MGNLFILLIQSNYRSAYFIDYIFRATLITCRLKANIDRTALFYTLKQHNNQALLTAFSIMLLDNKLREDAVSADRTYHNTEAAYGLPNDSIEHKRLELQHFNLLELMGGRIIHAPLGPDITHALDIGCGTGIITHEIASKLPDAIVTGIDLSPIPAIRPKLPNIQYLQGDFNELVRAGRSTPEAAKFQPETLDYIFSRLLVMGMPHWQSYVSSVAQLLRQGGWAEIQEWACVWYDAPASASPEAFLPHDVSYDSTNEVNEDALRSDEHSTDPYHIQPQPTWSALINEALRAKSLDPAAGNNIATYMHRAGLTDITTRRYIWAFGGWEGLSEEAKTFSAYADEVLTLLIESLLQRFGAEMDVDPREIENCIREFREDVRSGKRRLYTWYSVTVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXD6</accession>
    <name>A0A6A6QXD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_343343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXD6"/>
    <dbReference type="OrthoDB" id="3925521at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="32815" checksum="98DBB6F2227FAE4D" modified="2020-06-17" version="1">MSLSERNSSFVAASQDALRSLKMAQNYGTTSPQISNIQQQHPNNTYSTPSNSYPQPPNTYAQPSYPPAPTQQPPPTQPTAPLTPSETAQLQLLRKYAHILPLPMFPLLAATGPTNADLEYRQNLLTLVSDTQSPQLAPAQKIALHTLGTMTGTNFFTMDKALNGLGKALLALDNFTAQVRHAITLERWVTPPGAGCAPLIVDVWRCCSVSAPEGRGGVCARVSRDAKLRFTDKKVREKKVKRGKAWDKGTHAPISDLRVVGEDGGEVGLEKVLVMRRAMSTNEFSDFYTRFRKQWVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXN3</accession>
    <name>A0A6A6QXN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_526365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXN3"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF4">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 20 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="427"/>
            <end position="480"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="383"/>
        </location>
    </feature>
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            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="480" mass="53069" checksum="1385E7A6C49AED59" modified="2020-06-17" version="1">MADALCGPANPLQNFQKHTAVDRTLQQDRLISRQSPSQSFRSTSNQNVGLLDPEFDAFQAGHAPPLHPDFQHLPPHLSHAQLQPRFSPQPQAGGWASDFQRLQISSPQPQQNQHFRPQAQAPAAQSSWHQDFMSQQAPGVAQQSYQSPAQNMNMYGGMPGYGMGGFAGSTFGQSAFGGPMQEQNMSVAEGKQKADVGQFDESAFERAFAEAQAEMLQEEAAVEKVSSQLPTETDPILLGIKDKRYPVYLTMKLRSLISTGATMEAATYLSHLEQTEQEGTLFNDISEAKWCIDTLDIVANGQHADAIPEEIETRAAALIQKINGRLMSMFPADLATSLDNNWPNLWADLEAAGYITHGRNAQQPFQQEQEQQPRSEEQIRNEQDQMAQTAGKLLESVADNTSEKFQNSTFLELMRRLRDHEVRVEGDKVVETGSIDTAGNHPSSPGQHIPPTEQDLDLGRDFVSTMNGHEPDLGESRAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXV1</accession>
    <name>A0A6A6QXV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_427420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXV1"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="10947" checksum="DFE6EAA62080E41D" modified="2020-06-17" version="1" fragment="single">LPDIGHACGHNLIATTSLGVFLAVAEALEESNLPGRVRLLGTPAEETIGGKITLIKAGAYSDVDACLMMHPTSSSHFPDHSLGDAFDKTLATSTSSATFRGKSAHA</sequence>
</entry>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="328" mass="34596" checksum="BD2BDD3CAC23A514" modified="2020-06-17" version="1">MSSPFPTRQIARLGGHNGAVHAVTYSAGSSQYILTGSTDHSIRLFNPSKAASPSSTLDPSLPTPGLIQTYDAHGYEVLDLAVSADNARLASVGGDKTVFLWDVSRAVTIKRWSGHAGKVNACAFGGAEGSVVVSGSYDGTVRLWDAKSQSYKPIMVLSEARDSVSSVAVMGAEIVAGSVDGRVRCYDIRMGQVLVDVIGAPVTSLTPTKTTDSLLVSSLDSTIRLMDKPDGKLLKAYKAPEYTNTDYRIRSALGLSDSIILSGSESGHIFIWDLLSGSVLHKLRHSPATSSPPNPKKDVVSAVAFCPTRKEWASAGGDGNVIVWGMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYV7</accession>
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            <fullName evidence="6">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_12"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1214"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="164"/>
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        </location>
    </feature>
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        <location>
            <begin position="264"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1538"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497302.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1612" mass="177938" checksum="C27114FC2FB99064" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ00</accession>
    <name>A0A6A6QZ00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ00"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="82"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="37112" checksum="CD0382F626529D20" modified="2020-06-17" version="1">MATTIILAMPPPKGQEPSFYGRTPVQQRFILTYSCTFAAAFVVLGLRLYTRGCIPKRFGWDDLAIVLAIFPGIAIFDCNVRSLRRVYHRVNPNKWFRICVYIIAFIITAYSLATIFIVGAGCQPTDAANENCLNQLALRQAILNIATDFAMMVMPLPMLIKLQMPLPQKIVLGFVFMIGSSVVFTSIVRITYTMHLQNKPDITYYEATTCVWSSIELNFGVICNCLTVLKPFAKRHLPGLFSSLDASNSKSGSHPLSFFCRFRSKQRDPASSGFKLSSMNGGTENGKGDIVVTSTYRVEGKKGRDIESESMEDMITPIEARTEQRAEGWKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ79</accession>
    <name>A0A6A6QZ79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_536985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ79"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2497314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="14925" checksum="EFC7AF896F1840A9" modified="2020-06-17" version="1">MARGSCACKKLTFDNTGEPIKTVLCHCLECRKLTSSFFTTNMLVPATSFSITGAPKHYVFTQEAGDEFTTSFCGDCGTTVCKETQAEGFKGLVIVEAGALDVGSGAEDVKPEAEIWVKHRVAWLKEGEGLAQHQEMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZB4</accession>
    <name>A0A6A6QZB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_458721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZB4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="381" mass="44055" checksum="85DC989F4E7BFC33" modified="2020-06-17" version="1">MAESASPIGIANLPNQRHKIVAKRGAAFTIMVAGESGLGKTTFINTLFSTTIKNYADHKRRHNKQIDKTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESYMLQEQQPRRSDKIDLRVHACLYFIRPTGHTLKPLDIEVMKRLCTRVNLIPVVAKADTLSPADLAKFKSRVRAVIEAQGIKIYQPPLEEDDEAGLQHARSLIAAMPFSVIGSEKDVQTNDNRTVKGRQYAWGVAEVENEEHCDFKKLRAILIRTHMLDLIHTTEENHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEEALRKRFTEQVKVEEQRFRSWEQKLISERDRLNKDLEQSHAVIKALEQDVDSLQGSLNRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R050</accession>
    <name>A0A6A6R050_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_323455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R050"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2497732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="40452" checksum="DA1F901473A62629" modified="2020-06-17" version="1">MVSVGGLGWTVIAVMIVETLLATTFLTARFWARIRLLGGLRSDDYLLLATAISLAVVTVLCAFAAKKGFGQHSKALTVDENVAATKLLIISQTFLCLCVWFSKVAVADFLLKIVTQKWHKMVLQFCMVSVTILGAVTFVGFYTQCSPLALAWDPRVKGNCSINVTVLGTVNAAYTTAIDFILAGLPWLFLRKLQMKPKEKLIINLSLSVGIFAGVCGIIRVTKAASLSAKSDYTYETVQLQLWSTTETTVSIMCLCFPVLRPLWRRYVKGLSKGDSSGPFSSRERGYQLSGRTTTATNNKNGHSFTVSATLPGGTKHSKQPDNDSADSILGEDFRIHSTGQHALGGIKETKSVVIEYDDRDTERSQSGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0F1</accession>
    <name>A0A6A6R0F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_330958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0F1"/>
    <dbReference type="OrthoDB" id="3757673at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="24742" checksum="2EE018650ADEC484" modified="2020-06-17" version="1">MANFTGGDSPLSVTGSIVGIVALLISVSTIVQAIFIYLTAYRDAPAELSRITSSVSNTVDENSHRLRTGHVPGPIGVEIGKGGYSKGRWTAMLEEYYDAHLELDEELSKIKRQGERTSSLFNWNRILWVFKRKDLEESVRRVETLRMRKMAVALNALVDDVSHLKDVLERIESRIPQGPLRLPPARPPVEDYDLARPLRMYSTSVLGESATDIVRTSMDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0I1</accession>
    <name>A0A6A6R0I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kynurenine-oxoglutarate transaminase 1 mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_525125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0I1"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="40"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="429" mass="48042" checksum="33DBE16EAD19855F" modified="2020-06-17" version="1">MSATAERRDPFKPAARVASQNQDVWTIVNEAAAASPIQPIVNMGQGFFGYNPPQFVIEAAKASLDKVECNQYSPTKGRPRLKKAIANAYSPFFGREINPDTEVTITTGANEGMLSAFMAFVEPGDEVIVFEPFFDQYISNIEMPGGKVVYVPMHPPPNGSTTTSSASEWKIDMHQLEAAITPRTRMIVLNSPHNPIGKVFSREELLAVGELCVKHGIIILSDEVYDRLYYVPFTRVATLSPEIERLTLTVGSGGKNFYATGWRVGWLIGPENLIKYVSAAHTRICYSSVSPLQEATAIGFEEADKHGFWEQSKREMRAKMTKFNAVWDELGLPYSDPEGGYFVLVNMSRVKMPADYDFPPHVASRPRDFKLSWFLIKELGVAAIPPTEFFTPQNAHIVEDWLRFAVCKEDSVLESAMERLRGLKKYIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Z7</accession>
    <name>A0A6A6R1Z7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_298219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
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    </dbReference>
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        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="60"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="334" mass="37645" checksum="CBE243B8999E56C6" modified="2020-06-17" version="1">MDKVSQLFKDAMGVGKQPQEADDVVNRPPVRHALRLRSNGLVDLSTPGDEIAVISDRNCRQSPLLRLPPEIRNRIFRLAFGGDGRHIHVYDRSLDPTSNPSSTAASTPEPSKVAKFLGCSGSQKKKHEEELKHSPIGPLTNCMYDDHEECFKKPDAKSLQLLGFRGVLPWEAPQLGHDRMTLIARTCRQIYNECALMPYMLNVFSFSPGVIGTWMQRRIPAQKAVITTLFAEHLACSYNVMRCLWGNASAQRALSRDSNYDRRLFQGWTALKMVYISRPVVASVYGRRCLCHGDLVVELEEDMQDTIARRICAKRIDDILSIAPPGLKVELLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R215</accession>
    <name>A0A6A6R215_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_524547</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R215"/>
    <dbReference type="OrthoDB" id="3707610at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="52" mass="6002" checksum="4D124C656BADCEF4" modified="2020-06-17" version="1">MDDEHFNDDLAAWACFRLDRLQPGLRMIHLYDAHGVLTKGVLFVRIEKSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2K2</accession>
    <name>A0A6A6R2K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_558650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3552169at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="130" mass="14407" checksum="918902EDCA49E1D0" modified="2020-06-17" version="1">MSSEQGPQIEGTSEQGERIEASTEQGQRIVAHSKIIWGDGEYHFDIGTIHDKGFYMAYVYKGDTIGQDGCPALPCDSPEQAWGELDRMLGVWARQVQTGLPMTREDRLDILGGAGGRNWLAEKILKILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3K4</accession>
    <name>A0A6A6R3K4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_523815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3K4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="2"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="380" mass="41047" checksum="696502B535AE9CD7" modified="2020-06-17" version="1" fragment="single">MITVALCLSVFCMALDNTIIATAIPRITDQFKALNDVGWYGSAYLLTTCAFQLIFGKLYTFYSIKWIYLSALFIFELGSLICGVAPNSTALIVGRAIAGLGGAGIFSGAILIVANTVPLIKRPTYMGLIGGMYGIASVAGPLMGGAFTDHLSWRWCFYINLPFGAVTGAFIIFFFQAPRKGKKDESTFAQQIRKFDLPGTALFLPGIICLLLALQWGGSKYAWGNGRIIALFVIFAILMAGFVGIQIWKQEEATVPPRVFKNRNVWGSAIFGASLGASFFIMVYYLPIWFQAIKGVSATKSGIMNLPTILGLVIMSMISGGLVTVIGYYTPFMLASTILMTIGAGLLTTFETDTGHAKWIGFQFLFGAGVGLGMQQTLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3Y8</accession>
    <name>A0A6A6R3Y8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557375</name>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3Y8"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16571" checksum="7AC4FA88AC693EB2" modified="2020-06-17" version="1">MSPYPTATDITSIFKNMETGNYAEVFKRVSPNVDWTVMGTHPCAGRYTTLAAFQEGTLKRLGAIMKEPGIRLKVRNVIGGGEQAWAVVELMADAECKNGMVFENTYAWCMRFDEEGLVVQVRAYLDSTMVKQAVEENEGACESFRAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4E0</accession>
    <name>A0A6A6R4E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_547733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2499389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="302"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="593" mass="64524" checksum="C2983F0F01C086DD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4I2</accession>
    <name>A0A6A6R4I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_454249</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000100">
        <property type="entry name" value="3'-5' exonuclease/helicase (Wrn), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="53221" checksum="6189A1847256D84C" modified="2020-06-17" version="1">MGDNEPPSDDEASSDDNASDSDSEDVEKHIPLTYQIPRETLRAAMNTSKSNVDGSSWSYTMYRGPNDEKIDLHYCRNMEVAETVAQYFVDEQVLGFDIEWKPNASAAAGIKGNASLIQLASENRIALFHISLFKGTTADELLPPTIKTILENPAILKTGVAVKSDFTRLRKFLGVEARGVFELSHLYKLVKFSKDEPEKVNRMLVSLANQVAEHLQLPLNKGAVRESDWSKPLLIDQMRYAASDAYAGVRLFDVLEAKRKKLRPTPPRPQCAELGLPIALAEGVVVRKYKSRKVAVVLDEEEEEESDDYQSALEEQEAIEESDEETSSSLDLPEDELSDEVSEEELVAPPTKRVGHPPASSPTSALELANFWLDAWHAAMPMHRQPIATSGQMRAYALWHEQNLSLAEVAAVLRDPPLATSTVSNYILSAVMLEQLPFKEERIKVLLKTMPSKVVTQRYWRILRTLGVEDVGDLETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4Q6</accession>
    <name>A0A6A6R4Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4Q6"/>
    <dbReference type="OrthoDB" id="3912861at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24756" checksum="83BED9AB40D0D50A" modified="2020-06-17" version="1">MDLKVLRTYKSKRVSLYGQHPIQYTIALLFTTSKTFQLDDHFSHPRTYHPPPTDPRSAVISGCIVDGKSTVFYTDEHGFLKTLQNAAKTDSEPLATAGRAAYRDDLLTLNDQNVKSLTRDIAAISFPLLNSFTRSRLYYIDTNSTLQELQKEGSENWKVGQLGTDLGVTVKKHSPITAFLSVNSDSIKVYYYKDGAQANKPWVAFWNGTQKKWFTEFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5M7</accession>
    <name>A0A6A6R5M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_501593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5M7"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="234" mass="25159" checksum="A6599E1C14958F1D" modified="2020-06-17" version="1">MASPSTMCAACLRSARRIMLKSSTSSRFLRPSLPARSYTSPPAATPGVPLYLDFLAPAYKSRQLIALQSPRIAQSKAVQSGCRSFATTPAPQRAIHNPRKDENGEEMDIEITPRAANRLHQIMTNDSNPNLALRITVESGGCHGFQYLMSLTKIPSSLPESTSSSSEDESLSEDDTVFAGPHDTKVVIDESSLELLKGSKVDYTMELIGSQFKVVGIPGATSSCGCGTSFDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5Y1</accession>
    <name>A0A6A6R5Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_535689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5Y1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="36365" checksum="C25BEFB567D9DED6" modified="2020-06-17" version="1">MSTPPTTNLAWIIPPPSSPQSLSLTLSSPLPKPTPGPHQILLRITAISLNYRDLMVATHAYPLPAKPSLIPGLDGAGVIEATGPDSAWAAGDAVLVFSSTWYAGGFENLDFMTILGSGDMDGTLQRYMVLDDARAVRAPRNLSGVEAATLGTAGATVVNALLWGPARVRKGDVVLTLGTGGVSCFGIQIASALGATVIATSSSDEKLEVAKKLGAAHVVNYKKTPEWDVEVLRLTNGRGVDQVLEVGGAQTIVKSLKSTRAGGLVTVIGALSEGSPVDILPLILMGAKTVRGSMAMSKDMVEELVKIVEEFDIHPVVSKAFEFDEAVKAYEALREQKDIGKIVVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Z3</accession>
    <name>A0A6A6R7Z3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase with different specificitie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_248485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7Z3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2500502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="260" mass="27317" checksum="69EFE12688A4084E" modified="2020-06-17" version="1">MTDTINKRLTLQGKVAIVTGASRGIGAGVALDLAKRGAKVTIAYTSPRSSQPADDLISQIKALENGAEAIKVQADLSQVESADKIVAATRDAFGPSIDILVNNAGVEMAKPILESTAEDYAFIFDVNVRGAWLMVKAVVPHLRAPGRIINLSSVGGRCGFENFSLYSASKAAIEGMTRGFAAELGPAGHTVNAVGPGPIQSEMLDQIPKDLVDMQKKQTPMGHRVGTVEDVALIIGMLAEEQSQWVTGQTISASGGFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R885</accession>
    <name>A0A6A6R885_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_577997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2499953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R885"/>
    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021641">
        <property type="entry name" value="DUF3245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11595">
        <property type="entry name" value="DUF3245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="28649" checksum="1B0E5022D0F4D1E6" modified="2020-06-17" version="1">MPAVPSEADVVYNRMAVVHAKHQKLIASWLPPKTPEELANAKSEEELEREEKAIFAPVPEVLGVGAPIPKDVADGSFKRKNLSSNDKLLTQLLGNKAAKAHLKSKQTSKHAVPTQKPASKPVKGPSRQDDSEDEEEGRSSMFKSKRHKSSKISPEDDTDHDADSRKKDFVKSSNPDQPIKLPSSHSSTTTSTSKKRTRDADHDGSSDSSEETRKGTGTKKRSPPKREGKQDKKHTNYLDEVLSERKKKKKKKNKDLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R894</accession>
    <name>A0A6A6R894_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_186195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R894"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="193" mass="21104" checksum="5D5BA5243FE0B1E5" modified="2020-06-17" version="1">MQSQAPDVQHGLSWCSADVIPACSRSSTGLAEKALGHPSLKVGLSKTVNRMPTERQASCMHPVRHVARVWLLPETKAAFLADFSHQPLETNKETKESAKWRWPKLQGRGHDRQNRCMWCCGLHSGLGQGNGGSLCKSAIYTLQARNVSRLSLFHWSNGPSFGPHCPLHIPTADPSCHSGGEGVMRLQSPLCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8K3</accession>
    <name>A0A6A6R8K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_256671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8K3"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025523598" evidence="5">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="500" mass="55125" checksum="2E9572A38A34250D" modified="2020-06-17" version="1">MKLSQSYWFFISIFPTVALGGIQTALQATGGVIKGCLELQRLLPSQTFFADSPEYQTQQSHYWTSQQATDIHPRCRVTPYSTDDLRSIVKVVGRHQATFATKSGGHSTVSGASNIDDGITVDLAGLNSTELSVDDSSAWVGIGNTWFSVYRDPTLTSAGLSVTGARAGTVGVGGFLLGGGFSWHSGRNGWACDTVLDFEVVLANGSVVSANENDNPDLFWALKGGGSNFGIVTKVKIPVFKQDSMYMATTSYEGNDLPDVLVAMEDFTAEAEDPDAGLFMTIACDAKWGMCYNVMMFVNTASNTSSSTFEPFEKIPSFENGSEIMDMGDLSKMLSDQPGTKFRKEKFTLTFRNHRSVPLMLYLASRIHHYVHDPAYLRGARVIAITFQPLTSRHISSSGNAFGLDAEKEPLILFSAEVHWESSTRDQHFHDEFQSLESLFRKEAESSGLLHPFVYLNYAASWQKPFESYGDRNLKRLKDVRGRFDPDGVFTKLQPGSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8M9</accession>
    <name>A0A6A6R8M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_502783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8M9"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="393" mass="42944" checksum="E1F89B6E8EEF4396" modified="2020-06-17" version="1">MAPSPKIRVALIGLNAPYTSAPTGTNWTAIAHLPYLRESSKYELVALQNSSAERAAKSINAHGLDPRKVKAYGTPEEVANDPNIDLVVSSIRVDRHAGSLIPSIKAGKDVYVEWPVEANYSIAKELTGLAKSHNVRNVVGLQGRFSPIATTIKALIDRGELGRVTSSTIITTLNYTGPTILSSIDYFTDIKTGGNPFTIDFGHVLECVKEVLGEISTHHSLLINQYPEVDVVDPATREVVEKGRKNTVPNQVVFDAVLKSGAVLTYKQHDAAGVPPGATPRKDKGRLPVFDWRIFGSKAEVRVTSYDSIFPNIGSGGFKIEICKAEDGAVVEVELGADEFGHLPEPARNIARLYEAFAAGLGERNEKRKWYPDFEYALKTHELIEGMYKENGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R951</accession>
    <name>A0A6A6R951_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_522016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R951"/>
    <dbReference type="OrthoDB" id="5335493at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="42242" checksum="E4E81CBF44B00276" modified="2020-06-17" version="1">MYPGQHTRTVLIRWNERPGGVPRYSINLAKFVRPLHLQVKIDGQWMLFMQWIEELPCQKKEFVGELGYIRQQQWWASNGQRFRLMDLPKELRLCVYEQAMGTDIYPQLSPQGLVSLGKGYEYPWNYRRKDEVQGPNLALLRVSKQVSEEATKTAWEGSRMSFAQQNSMAFVIPGLKNLVPRFSVLTHISLCFQTSEYIQFFEVQVQPWSGIPGYFNHNTSARAVLSKTNLPNLKELGIKFASPENPSNSPWFRSSSFFPNPLWGWYTSDTDAPVVCHKVTVDWIMAYAKASVEHIPLVYVEGYIKTSLKEKWNATFKAQRNGTYSDISSDLLAIQSLTLEDMPPRCKCTTQCERHSLGPWEFDFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9J6</accession>
    <name>A0A6A6R9J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_613377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9J6"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="320" mass="35027" checksum="D3D0529892287BDB" modified="2020-06-17" version="1">MGQLNSRSQAPLEDPALGGSIRHIEELRLFELGDARYLAVPLARTVQLPSIAETPTGKISVTVVLTPQGQIPNQTWVDNNFKEWYASDDVFHHDFLANVVFVSAETEPAGLTQMSDHMRHTWNTSWCTSVPQTSVGPEVSSGPYVFWNGQLCKAYRLYDDTNQAFIVGTKPKTSTGFENLRVSGDFYTTLSLAVPSRIPQDRSAMRPLDGLRFAVKDVFEIEGLRTTAGCRAYYSLSKPASKTAPTVQKLIDAGAQLIGTLKLGSLITREEPTESTDYQAPFNPRGDGYQSAWSSSGGSGAAIAAYDWLDFTISTDTKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9T8</accession>
    <name>A0A6A6R9T8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_555652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9T8"/>
    <dbReference type="OrthoDB" id="5362656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="338" mass="36970" checksum="19F43D1BBDB9980D" modified="2020-06-17" version="1">MANHFSFPSGFHLLIATHKRVFSWSHDGLVPVFRSATNGILAARQSGDGRGILAIADSQIVILQNVRPGMSREYKLKGEDGELRVLQFSSDSRTLFFTSTLSNAVQTYSIDYSRFLEPAQTHPSPPTVVATSSNSELLLVASDSPPTISIQNLSTRSAPLEFLPLASLSRVVCASFHPSHSTTFILGFADGTLAVYRIPTTSGWLALRPPSEIGRYERLHKASMGGIVAAEFIYGYDARVVSVGRDGKCRLVDFGRGTVMLRTWHISGPATSLSVLPVPKLSPPRRRHRRDADTEWKVLIAIGREDGKVLIFNTIGLLEREVKVGAGVFGLQWVEDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAQ6</accession>
    <name>A0A6A6RAQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_451404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAQ6"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="863" mass="96691" checksum="57A6B0C18FF8D145" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB67</accession>
    <name>A0A6A6RB67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_557163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB67"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="138"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="458" mass="51305" checksum="13E338188200DCC3" modified="2020-06-17" version="1">MATHSPSLRRPAELLDQHFVSEDPESQWKSRTSYTDTDIQDISSLLDHVKPTWSKFPRAYVVLRAISKLDQLDPLIASGFTDHCFPVTETRTLPPQLPPTTRAEILSAQGMILTKSMDIEKGERGRHMHFGPGELIPFESKEVLGLGRYGEVDRVISLISHKEYARKQISRRLAFGDKWKREAVAAFAREVSILSSLHHRNIVQFNGSYTDTSSYCLLLSPVAEMSLSCCLRNPVDASSPTSLTANVTPWMGQLSSALSYLHGKRIRHADIKPDNLIIKQRDIFLADFGISRAYSYGESSTSSGPTNHTARYCAPEITLQERRHYSSDIWSLGCVFFEMAAAKKSWTTQNLEAFFGQTGTCEPYIRQNLPALKAMLVRLRMGSPFSWSLHWAEEMLKLDPRSRPTAAQIAAAAVDHVKEGYPPSEGLVEQMEVDQLGGRTQATIVLEDMYDGPKSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBI5</accession>
    <name>A0A6A6RBI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_545663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RH60"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="251" mass="28420" checksum="42E8A3DB3956795C" modified="2020-06-17" version="1">MNQNVTIRSARLKDQHVMAYVCGKAFFNEDLFGRVMHPHRDKYPDDVNLFWLRHLREKWWDWNNEILVATVSDDGGMEKVVGVAIWKREGSGSKKLSWASPYRILPYLARLYNAVHTFFYPNRAANPAVENILTDSFPYFSHHFTTPASRQEQYFLDVLGILPAYQGRGIGARLVRRGLEAADREGVCAAVMSSDGNDGFYKRAGFDEVVGWATEGEGNPLAKEKTTGGAILFRWARVDGQPEKTGVQNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RI74</accession>
    <name>A0A6A6RI74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_612715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RI74"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2503167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="995" mass="110073" checksum="7561CB8774477C57" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7U2</accession>
    <name>A0A6A6Q7U2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_587124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7U2"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025607761" description="Dipeptidyl-peptidase V" evidence="10">
        <location>
            <begin position="20"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="492"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2488362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="701" mass="77054" checksum="96936E2C21E28715" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q806</accession>
    <name>A0A6A6Q806_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_226967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q806"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2488445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="30106" checksum="80BA4E45A1221890" modified="2020-06-17" version="1">MADNSQPVPRGPPTGSLVFPGALRDRLEPLLAQALIDPVAHYQHLTLTFATSLDSSIALAPGTQTALSGGMTKGMTHYLRFKHDAIVVGVGTAVADDPGLNCRLRDAGGYGGKGLRGQPRPIVLDPKCRWQFSASSKVMDLAAQKKGKAPYIICTKEPPEDRRALLESLGGKFIILDPFSDDGKLPWKQILHALRREGLNRIMVEGGRTIINDLLEPQNHELVDSIIVTIAPVWLGQGGVVVSPPQRSDDNGQPIAAVRVSDSKWEIFGKDVVLFGKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9G7</accession>
    <name>A0A6A6Q9G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_223891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9G7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="145" mass="16308" checksum="AAB2EB0701BAAB3C" modified="2020-06-17" version="1">MTRIDERTPLLPINVVEKEPLPTDDRSYFSWEIWEPKKLSRQEYALIASISALAGFIASILNLSMKNPLLLCRFGLYQLAHLLPACLYIALPNCVVFLIAAPFVVQSSQVRLYRCGGVFCYLLVSFCAAWAFGTSVRTGNSVCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAB0</accession>
    <name>A0A6A6QAB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_435375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAB0"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="41078" checksum="08242F9CB41E7CFF" modified="2020-06-17" version="1" fragment="single">FFNPPPHTPALATGRPGRHHATGNDSFSTSKKRSRHDISDSYFPSSDLWDHSVGASIDRAGNAKSPPPLANEKYHLAGGSETPQVLANFQREIDDYHNLGGQRRGYWDTAPADMDGQSVSQSTLRNLITMVGGVAGKLVQYCVVPFRGFHAGGGQGYDIQEGLAGSNVWEKLSLNTPDLKTFSDASTLPGRFPAENYGDLSIAPVDESRPRTIKRLCTDDREWVMVQDSGDADSRASSPRLSERRLPALSTPISPSQIPRPVSRASMAHGSSERPSRIPLSRRTSSARVSLVSNTGSPAFRKYSRQSYGSPAMFQVQQTSPLPAESQRLINKVKRDEMEEEMRLRKMSAQTKLMLRQAKEALGSKFEIEDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAP9</accession>
    <name>A0A6A6QAP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_568402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAP9"/>
    <dbReference type="OrthoDB" id="3690055at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2488527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="220" mass="25754" checksum="D0156972849BF7DF" modified="2020-06-17" version="1">MASTFMAYLDSNLRVQSDGLSGGVLEKQIFLDLLHNPLPNLPAPRDPNCSICHDTMTDPKHVKVCNHAFCWKCLERWLDECEKNTCPMCRDSNKLFNTEFEIFVANLLPKRQERYQGPWPVDIFQDRRDDIARAGGLEAFRVIFDEYVRYKNAGGTHLNNNQNWSLTSHFWVSNVRSLVPWNEAYESFRRGHDLWNLNYEMVRPVDLRGRHGSIKLMMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB14</accession>
    <name>A0A6A6QB14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_160469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB14"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="247" mass="28231" checksum="DBFA10AA9C3DB094" modified="2020-06-17" version="1">MVWVKDDFFGSQSSHSATGGSGFSMTWTLGRSRRYCRISTLTSFELIIFVAQSLHLLHRRSEIELVLFELCGQTSHFSFLTLDDRNRPLVRSASGVLLSFVIGLASLLAILSVSFTLIFKVLVSIAEVPLARLQLILCRVHVRGPGLLPHLLVPFHVQHFPGLNREAFLLERYSAWSVLYSTDYKPYDLNQAWFRDLTTKHEESGMRRFTFSILKQRSKRRTQKQEESQSRLTPRPFSQIGGIVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC90</accession>
    <name>A0A6A6QC90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_161236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC90"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="130" mass="14545" checksum="D34C43574A4252E0" modified="2020-06-17" version="1">MMPLTAPTQRRRRAVGKASGGLGERAAAWRFLNFNCSSITRSPRILLHALLVAPNNSRSSPARSLPLGLHRRPPAAATYRHLQLLIPSRRRSSWPCSDTISATRTPRDHTPLPLQTLLVDDQSFYTLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCN6</accession>
    <name>A0A6A6QCN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_168630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCN6"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000270">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="497" mass="55997" checksum="2B706FBF314117C2" modified="2020-06-17" version="1">MPHSLTSEESTMPSKPVGEYPKTGIDVLVIGTGLAGLTAAIECVRKGHSVRVLERNATINTAGDMYFMGLSATRFFKHWPELAKEYDEISLHNAWIETFKHTGEVVITPKKVADRLKADGLDPKTPPGTFQMRPLIYKMFVRQLERLNIPIEFNRRVVDYFEDEKTGKGGCVTEDGKRYEADVVIAADGVGSKSQKLVGGQVRARSSGRAMWRAAFPIEHLDQNPEVKEFFKMMPGNEPIVRTWLGPSTYALTLTREDVMVWIVNHDVTGTEAESWNHTIDKQEVLDGLDKMPGMEKHKWAPIFKDLVNCTPPDTIINFELLWRNPQPKWCSPGARVIQIGDSAHSYLPASGNGATQAIEDAISLASCLQVGGTENVPDSVRAHIRFRFIRNSCAQKLGFSNAELLQDTDWDKVKLNPRRAAPRLPKWVWEHDPEAYAHENYAQCVKSIKADVPMENETSFPPNYPKGYTYKPWNIEDIMEDMRNGKEIDLGPGDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCU6</accession>
    <name>A0A6A6QCU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_531277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCU6"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="25497" checksum="EF2130CEA56882CA" modified="2020-06-17" version="1">MPLFWKRNSFTLFVKGADSRLAIGFLPQPRPQTQAHVKPVQHLRLFSSLDPEYSKLIRRWSLCFDTGYSGNTHETVTWEKYVWDSAKRIMPPRITEHALASQYLPHRFITKIATCETDAQSRLSYKHSAFAHLCAFLNRLDFAPTFRYLDLGVGENPGTDLAKESFPAERCQHVYMYKFIEYKPGEELFKLLPQLLQTGTPLVPRSKEDRAWDWLELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDH8</accession>
    <name>A0A6A6QDH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_597214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDH8"/>
    <dbReference type="OrthoDB" id="10666416at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="807" mass="88196" checksum="49BF4BD8DC58BCB1" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEV5</accession>
    <name>A0A6A6QEV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase GliP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_595397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1583" mass="175019" checksum="D58FE6B5E8641DA7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEW6</accession>
    <name>A0A6A6QEW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_469260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHC4"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="434" mass="48401" checksum="563DA19DBBF91BAD" modified="2020-06-17" version="1">MAVTNQNHANYQARLDFIQHLLHDRLDLKEDAEIVPIQYDPECPFKYNNSVYRISLPLPLPLDKSTKDKARQPGCVPIPAGTKTLIMRLSNPIAEGMNPETRIENEVAIITLASTALSSFHPHVVPSIYGWASAAPPSSQGWILQELMPGTPVNEAFKTLDLPQKQKIFAQMAQLLKALQDYEIPASITGFGGVTIDENGRIVSTAMTSVGLGPWPSYEAHFIDRLALALRKADANSYIKGWRANGVRDRLDCFVERGVPAQFESLSSKRDRVIVHADFTTNNLLFDAASERITALIDYDFACILHPSYEFLRSFDGAGGQFRGWSGDEASEQTAMREAKLRGFPSPIPPTVPDGVKWDVAKTWEDELEKLDVRRPRTIAGIDSVADVDTTLRSILPWRVTNSDVLWLQSEEVIVSCRNENEEQLVKLLGRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHH1</accession>
    <name>A0A6A6QHH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_516138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2491652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHH1"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2491652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="317" mass="34212" checksum="1D0BA2D95C0E497D" modified="2020-06-17" version="1">MSPSPKDVASKAAEVVANNSSAKEYKKESTPARVLGAGCAGIAELMVFHPVDTTAKRLMSNYGKVTSAAQLNTIIFKDKAGASVPGRFFSLFPGLGYAAAYKVLQRVYKYGGQPFVRDYLAKNHGNEFDAAFGKGNGKAIMHATAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRGRGLIAIIKDEGFGLYRGWGWTAARNAPGSFALFGGSAAAKQYYYKLTDYNAASWSQNFVASIAGASASLLVSAPLDVIKTRIQNRNFENPESGFRIVSNMMKNEGFSSFFKGLTPKLLMTGPKLVFSFWLAQTLIPAFNKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHK4</accession>
    <name>A0A6A6QHK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_467962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHK4"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="47031" checksum="803934BC8BC06E5B" modified="2020-06-17" version="1">MSNFAPPISRDGFVYHGALYADVGNLNRHPRASITELTNMLRPKLSSSGKSKTTETPKDQVGHWYFAQLKHYGLPMCKDKNAAKVRLLNALNSGGLEVPGEVKRLEGALKREYDAANRKAKAEMAKAEGTTAPRKRKAEDGGEEVAKKVKGAEGGLGAPVSDGLAKKDSNPKLNANATKNGATSKQTARKSGPKVKDEANAKKEPVVKKQPAVKKEAGVQKEPAIKKEPSIKKETAVKKEPIVKTEASVKKEPSPKKEPRLKKEPAIKREQQNGNDSPTYRLNAFYNLTCPAISDDWPYQSEGMNLRLRADQDSGCLWGNIQKFGPWSGVIWVDIPPGPIFETELQFRWRMREDGTGELLFRRDQLGTLMFSDDGNMQGRIYGLHGEVTVFWGSRRIGPAGGGSAQQFKAEWDGFVQEAYGRERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHL0</accession>
    <name>A0A6A6QHL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_120948</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHZ7"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="273" mass="30535" checksum="E604FC8BFA25CA4A" modified="2020-06-17" version="1">MRFLCLHGRGTNSDIFESQLAPLFSRVSPHHTFDFVDAPFDCVAAHGISQLYQPPYLTWHTQYEPQHVEPVHDFLRTVIEEDGPYDGVIGFSQGAALAASFLLCHEHYAQIRDPGRRHKPPFKVAIFINSVMTFSPSEHIGSNISQHIKSQEEKHMAFIEGVDSLGAEDFTPTETYTTIDGDSIYGFPKDTFAPRISIPTLHLYGTEDQFLEHSEELVGLCRGDRTEVLPVRGGHELPRTNPAWDKFAALFEMVAMTAALMDPSSRRGSATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI00</accession>
    <name>A0A6A6QI00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pex19-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI00"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="32422" checksum="E9868976895403F7" modified="2020-06-17" version="1">MADKAPEKLAEAAVESAPDPDEDDLDDLDDVLDEFAATKLDAKAPAPAVSGPGRPGGVPEPAVADEDEFALQLQAGMADLLGELETSPELQKQFEDMVKDLGGAAASDAGAGAGASAPGASSSGDKSASTKAAEESFQETIRKTMERMQESGDQASAAAASSDPDDIFAQMLKEMEKGGFGGEGSDDDFSKMLLGMMEQLTNKEILYEPMKELLDKFPDWMAKNKEKTPKEDLDRYEEQHRLVTEIVARFEMSGYSDSNAPDREYIVERMQKMQAAGSPPPDLVGDMNAAQEALGEIDAGCPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI04</accession>
    <name>A0A6A6QI04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sister chromatid cohesion protein-like protein Dcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_529441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI04"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="343" mass="37323" checksum="31BE61FAF8657CD2" modified="2020-06-17" version="1">MATQDDSGIPFSVVHDQQQFRLVELPPEILALIDSPNAPILSIKSQAPPTASTASSSKPAYAVLCTPTQTYQLRQVQTSNSVFATKCVLTSHGDSMPVPGVSAIATCPTTLELHPVTGTAIPYLKDALPLYDLVDDEMVDAAGNGKSKLKVFSDVPLSDAQCEWGWRELIAFEFAGSSFRPSAVTLLKLWKSINVAALAEGIDLNKQFLTEDLLKAIDDEGYPVDLFHALLLRLAADDHVGDATWTSMDRQITVPFVGRTLLASEPSNQDLHTAIFIESWKDNLPELWRDDAKLDTIKGLYILPTSTTISIKGGDDEGSGEGSKGAGSASRKWHERFARARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIL5</accession>
    <name>A0A6A6QIL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_529443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIL5"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="97"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2492071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="571" mass="64285" checksum="7B6FC05BA7B8F4FC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIL7</accession>
    <name>A0A6A6QIL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_516383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIL7"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="398" mass="43779" checksum="4154775EE11F387F" modified="2020-06-17" version="1">MAPKEIRWGILATGGIAQTFTKDLTVDPTTRGVTKVKHVVVAAASSSSKKRAEDFLKECNWPNAKAYGSYEDFVKDPNIDVIYIATPHSHHYQNAMLCLEAGKNVLCEKAFTVNAAQAKKLVEKAREKNLFLMEAVWTRWFPLSIYVREQITSGRIGTVYRVQADLSMADDPDKTYADGKNRMVNMDLAGGAQLDLGIYALTWCFQTLYHTQPASERKPPKVQAAMKHFSVTGSDESTTVLLTFPRSEKLGGDAHAVAMSSIRVATDPAKKNVAGPAIRIQGDKGEIQVFPPAFRPLDTRVILSDGTVEDKHWAQPGPGKGSGFYNGFGETIQPEGEGQGMFWEADEAAVAILEGRKEGSFLGLEESIVIMETMDEIRKQGGLKYPDKIETLNYPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ15</accession>
    <name>A0A6A6QJ15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-coumarate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_107039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ15"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="452"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="552" mass="61908" checksum="309CA680261E3438" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJN0</accession>
    <name>A0A6A6QJN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564765</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5353310at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="81" mass="9392" checksum="145BBF705B0967FE" modified="2020-06-17" version="1">MAVVRDPAFWRRFSMAVHLDEEAQNPQARPELKHSDSWLARQKTKSSRRTFICWIFWLVFAGLVAGIVIVVLFLKAKGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKA0</accession>
    <name>A0A6A6QKA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_468421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 269.34</strain>
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        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="PCF11-like"/>
    </dbReference>
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        <property type="entry name" value="Pcf11_C"/>
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        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pcf11_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="69795" checksum="3B2E0C77E14D07E4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKF7</accession>
    <name>A0A6A6QKF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-beta-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_515424</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="287" mass="30757" checksum="E5BE8AA1057C75E6" modified="2020-06-17" version="1">MTNKVALITGGASGMGLAVAQALAKRGNWTLHLVDLNAEAGAKAAADLPNAHFHKTNVTSYSSLASTFEAAFKISGSIDFVFANAGIVERDDFYAKSDLAIPPEPNQLSIDINLKSVVNTSYLALHFFRKSPHKGKDGVLIATASCGGLYPSEFCPMYSAAKAGVIHFIRSIAYSYHANDGVRTYAICPGTVRTGLMTGEEWKSFPEEYFTPISTIVSSVTALVDGGALEDAFGVKLPAEKAYSLIVEINGQNHYFRNQVPFCDDQMASVMAKTSMEAQAARIHGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMT5</accession>
    <name>A0A6A6QMT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_491715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMT5"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="287" mass="31376" checksum="BCF08EE75E22AAE2" modified="2020-06-17" version="1">MSFTTTATIASFGGKLLKLTHKATSTNCDMALNLYLPPQAAKSGTKVPVLFYLSGLTCTGDNCAEKGFFQHGASEKGIAVVYPDTSPRGLKIEGEDEGWDFGTGAGFYVDATKDPWSKGYKMYSYITEELPKVLFSSFDQLDSSKVSITGHSMGGHGALTLFLKNPGMYKSVSAFAPIANPINCPWGQKAFKGYFGEDQQAKWADHDATELVKKWEGPLNLLIDVGTGDNFYKQKQLLPENFIEAAKEAGNDSGVTLRMQPDYDHSYFFMASFADDHVAHAAKYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN79</accession>
    <name>A0A6A6QN79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_563738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN79"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="402" mass="44888" checksum="07085034B36B2481" modified="2020-06-17" version="1">MSGPYTKIPSSAKGHPQPYTLAVPEDDLKEFKTLLQLSRLGPVTWEGKQGDRPDGISLLGITRAWLSNAKDYWLESFDWRAHEKHINSFPNFKLGVKDKDGDESAIHFAALFSEKKDAIPVVFLHGWPGSFLEFLPMLSLLKNKYSPEELPYHVIVPSLPGYTLSAGPPLDKDFTTPDAAFIINNLMIELGFGNGYVAQGGDVGSFIASELLSQYNECKAKHLNMMIITDPPENAEVSDVERKGLQRTQAFRQRGFAYAQEHGTRPSTIGHVLSSNPLALLAWIGEKFLDWTEEDPTLDTILESVSLYWFTDAFPRSIYPYRGLVSGQKQPDPTDKPFGFSYFPFELSPVPKAWAATAGNLVFHREHSKGGHFAALEQPSLLLQDTEEFVAQVWPGVSQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNL1</accession>
    <name>A0A6A6QNL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_550872</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNL1"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="17">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="18">
        <location>
            <begin position="139"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2493955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="274" mass="31482" checksum="889802BE28330577" modified="2020-06-17" version="1">MANSKYEYVRAFEQPDVLLPNTWIVVRIDGRGFHGFTTKYKFKKPNDARALELMNAAAEGVMRELPDLVVAYGVSDEFSFVFHKDCTLFERRASKLTTTIVSTFSSYYVYLWPKYFPDTPLTPPLPSFDGRAVVYPSVRNLRDYMSWRQVDCHINNLYNTTFWALVQLGGMDAQAAEKELTGTLSADKNEILFSRFKINYNNEPEMFKKGSVIFRDSPLSHPLDDAGFPQPLSKTATEKDRKRRVKARIVVAHIDIIKDEFWAARPWILSGKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP03</accession>
    <name>A0A6A6QP03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_562918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="473" mass="53212" checksum="328704596AF10D5B" modified="2020-06-17" version="1">MPFQFIDSNASIDRATRRRIRSHVAMGKNVGRKIVRPSRIKAFERRPETSKAIIHIPKISEHTYDLECTKDMVPGTPKLIGDWLSVLSFPEQPPGSKHLVQRAFSFISAPRHVPELSDAIDSTGASAMWVQFMFLDEACFHCAVAVSTIALNNLVTKQEEPAEALRHLSCTFRLVNERLSGKDTVSNTTIAVVLLLTQYERIQNRYCQGLVHLEGLHRMVELRGGICKLTRDAPGIAKKIFSAELEYALFLGSATRFSIEDIIPTSTAVVGLASSFKHQDSGRHHPNVLDTKLFKQLSTELQDLLVDMVYLAQLLNDASDGCRSALNSQIFHDTLILLGYRLVRIRPLGGPRSTSPLINIVHLGLALFLMTLLRRLDRRIVEIPLLSQLAHSAAKEELEDEEESHELLLWVLFIGGVSVFKQIDDAWLDPKIVRTRDALSLHTWDDVRRTLIKFPWVGAVHDNPGQLLYKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQJ4</accession>
    <name>A0A6A6QQJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQJ4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="63" mass="7029" checksum="974CBEB9E122490E" modified="2020-06-17" version="1">MGLRFADRRQEQSFPFIFAAAAAQLASALFGLPPRPILYTKYADDGLRFWKIGKAVGMTDHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQP9</accession>
    <name>A0A6A6QQP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_582560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQP9"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="225"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="39581" checksum="24970BE9FD713012" modified="2020-06-17" version="1">MPQTPSAPLNPHERPPEQVKNVYKTYQKMKPKELAVDPDIIDFTRGLSEIQRASINVIEEIDPKKLNEAFRDFEGIESSSGDEITTPIRVYEHSNMPGLHILPSLLPPSTQRLLLTRLLHRDLSNPTHLTNIHTHYTLAYPPPTAFSPTPSLFTHPPTSPLPIAVPLDPSIHRPFPAHPLLTRKLRWLTLGGQYDWTAKRYPLSPPPPFPPDIAALLDSVFPETRPEAAIVNLYTPGDTLSVHRDVAEGSERGLSSVSLGCEGVFVVGFSGEGEVGTGGTVLTFRLPSGSAVYMSGTARWAWHGVPQVVAGTCPGYLANWPAEERGKDGEDAEGGEYEAWRGWMANKRVNLNVRQMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS08</accession>
    <name>A0A6A6QS08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_383239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS08"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="302"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="692" mass="78251" checksum="57734D177274F88C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS33</accession>
    <name>A0A6A6QS33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutathione degradosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_527632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS33"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M20"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="entry name" value="DUF3425"/>
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    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="222" mass="25525" checksum="17830212F3A2024D" modified="2020-06-17" version="1">MSERLQMFMKQKRQMIQEGWSVEQVLGPLEMYPTVNSCNSMTDSHSMTPNVCEWVVSMMSWMNIGRHPERMAMTLLGVLFLTWAIVPSEKNYQAMPPWMRPTPTQIIVPHPAWIDMIPWPEIRDFFIRFADQSHGMEVLQTFVSSLSVNWNSLLSNVAVEIPNTNMLALSQSFEVYIRDLGNWSLDPAVLHVYPDLAGMACFAPIASRSSRLDKMDGQYMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU94</accession>
    <name>A0A6A6QU94_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_355974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
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            <begin position="100"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="707"/>
            <end position="716"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="755" mass="85418" checksum="5002B99E4822F283" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUE3</accession>
    <name>A0A6A6QUE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein YmL11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_460057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37288" checksum="345C21A0885DAE89" modified="2020-06-17" version="1">MPPRIRLQTRQLKVRIYHHQIPSQPCFYASLATATTPAPPIEQTIHSVSPIARFPPTQPPSHKPPEVRKSQLHREYQSLLKSSPLVLIFQHNNLRAVEWMGIRRELAIALRKVDAELAATGHKDLYADAIKIQIIQTGIFASALRVVEFYNPESTELPTQHPSNPATATLAHGLSRQAHEAASDRKKKLDLAPLLSGPVAVVSFPAVSPQHLKAALSILSPSAPNFPAPKRKANPSYHEPAVQNGIQKLMMLGARVDGKAFDQEGTKWVGGISGGLDGLRGQLVGMLQNVGAGVTNALEGASQSVYFTMEGRKYMMEEAEKGPEEKKGGEEAKPEGEEAKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUX2</accession>
    <name>A0A6A6QUX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_561039</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2496205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3791583at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="150" mass="16801" checksum="074C6FB2C59F0BB9" modified="2020-06-17" version="1">MSVYKEVNTPASYINFDQLLRTKSTPPTFYQYHNLSYHSKKIQLRISSQSNTQLQVLPHNQTHNTTKPKTKMSSQNMSAPKNSFDSASTTSLLSASSSEKPTKSTSSAKKIYKAVVQHAKEHHQSVNAAFDTYYGPGLRNGRYAPTTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUX8</accession>
    <name>A0A6A6QUX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_538601</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUX8"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2495996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="20936" checksum="1B2CC289F28B7609" modified="2020-06-17" version="1">MGLTFSKLFDKLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVNEAREELQRMLNEDELRDAHLLVFANKQDLPNAMNAAEITDKLGLHSLKLRAWYIQSTCATSGDGLYEGLEWLSNCLRKSGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVA6</accession>
    <name>A0A6A6QVA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein rad10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_526823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVA6"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="39420" checksum="93455B09F154CAF0" modified="2020-06-17" version="1">MDDRGAQSPSIPPPVTPVQQPKPQALPQRSGPSALLVSPRQKGNPILNGVKAVAWEYSDIPADYVLGATTCALFLSLKYHRLHPEYIYNRIRDLRGQYQLRVLLTLVDIDNHEESLRELSKTSLHNNVTVMLCWSAQEAGRYLELFKTFEHTAPTAIRAHQSTSYPDKLVEFITTPRSINKTDAVGLVSNFGSVRTAVNAGPDEVALIAGWGEKKVQRWCNTVREPFRVKKAAQRGLDREDSRTGRPSAPTQAPRTAAITNDFAATSIGTAAPAMESSLNTEHASPNQSQREEIPEVQPGLTLDEDEDEVMRQAGEQSGPLQGAESRRPVSDPPAERKSGDEELSEGVMAALAKLRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVB3</accession>
    <name>A0A6A6QVB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_572293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVB3"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="11">
        <location>
            <begin position="234"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="343"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2496064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="511" mass="57989" checksum="F83EB34E8686FD19" modified="2020-06-17" version="1">MPPMVVIPIRSETLRILKVQHHNVASVICNRVNNQKEEQYLVKWSSKKPTSYPVFSWHTPLELVNCLELVQDYLEAKQTHSSRKRKSPDTDTEIDRRASPANRLLSSSRASSTSSTERSSSSSGRTINAEIKTYNGVLEESKGAITAKSVTQPDIPRISVADIPTLDMVQTARSSSTYTAENMIRNEILQRLRALPGAKVHLSNVHDRSAPSLRFKFIAESVLQEGVFKADPATQIGCQQCRPHMGRNIGCEYTKKCDCLEYASVDEARLSDEQKKEYRTIREEGGSTIGLPKKFPYYADASDRTGCLVPFYLRSRNPIYECNDSCACGPFCRNKNVQRGRHVELEIFKTKKRGWGLRAKQDLREGEFIDTYRGEIITDEEATRREESGGKAKASYLYSLDKFAESEGLSQEELYVVDGEYMGGPIKFMNHSCEPNCRQYTVSYNKHDCKVYDIALFACRNIPAMEELTFDYLDKDEEEDDDDEAVESSQPSQESVPCLCGAKKCRKWLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVG0</accession>
    <name>A0A6A6QVG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVG0"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="250" mass="26084" checksum="CA1376A5C7EA58A4" modified="2020-06-17" version="1">MAPPSALPFAKKVIAITGAARGIGLAIARYLAERGANLALADVEREQLEASVKDLQRDFPDSQITSTVVNVCSSSEVDSWITSTVSTFGELYGAVNNAGIMGKWGNIDAIEDQDWDRLMNINVGGVMRCLRAELKVLVEGGSIVNTSSVAGLKASVMLAPYVTSKHAVIGLTKCAALEAAGRRIRVNAVCPGPIETPMLVEVMKGPALPGPPLARAGKPEEIAAMVGYLLGPESLYTTGACIPVDGGFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVR1</accession>
    <name>A0A6A6QVR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_581641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2496356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="503" mass="54509" checksum="2FDFA2233DE7E403" modified="2020-06-17" version="1">MAEATDPQPLPYVPLQPFNNGSIATGGDSLLYDLNVFYNAGDIAWMITSTALVLLMIPGVGFFYSGLARRKSALSLLWLSVMATAVVSFQWFFWGYSLTFSHKAGKYIGALDNFGFKDVLAAPSVGSVRIPDLLFAVYQGMFAAITVALAVGAVAERGKMLPCIIYMFVWTTVIYDPIACWTWNPQGWVYKMGGLDFAGGTPVHISSGTAALAYSYMLGKRRGHGTQELNYRPHNVTHIVIGTVFLWVGWFGFNAGSALSANLRAVMAAVVTNLAACVGGMTWCLVDYRLERKWSTVGFCSGVIAGLVAITPGSGYVPAWSAVVYGVCGGIACNYATKLKYFLRCDDALDIFAVHAVGGFVGNILTAFFAADYIAHLDGFSHIDGGWLNHHWIQLAYQLADSISGGVYSFGGTCIILGCLDGIGKFVPALKLRATEEEEILGIDDVEIGEFAYDYVELTREVKVTDDEEDDLSQSDDQHNMAGGPQHEKNHDSVDSAGHFLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWB4</accession>
    <name>A0A6A6QWB4_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="247" mass="27713" checksum="322B6F94DA096DA9" modified="2020-06-17" version="1">MANPNRTVYSGPPLSGPGILWINSKITAPDKLSPELFKTWYEEAHIPDIIGAKKGSVLAAWRYQCANPERPAPYLALYSIPDLAFLQTAEFRAVPMVHEMLPEGGPIHKFANFDTRYYKKIQVFEKEGKTRPGMSRPAIQPAEGMEEELDKWYREEHLEQVSNEPGWIRSTRFELVFKVGDKGVANSEVTPKWLAIHEFEADGLLGDMPRPLNPVSDLTKKIVGNAIKVDAAKFTLIRGIGDELAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXN5</accession>
    <name>A0A6A6QXN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_538033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXN5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="350" mass="38096" checksum="8FDF8E1F76A48D99" modified="2020-06-17" version="1">MLIPKEPGMFTLSCRSPWRGAAWASVGREERQSWQGLGAACDCFNGCCNSRKHWVTCDATARQSSLSGDRSLERGHDSALKHRGGGIYCSVWGSLSRATRSYLILCNSPGALNSAGSATKMLGGFERAECCAISTSTAASVWPIPGGGTLPIPSARSCRLGSSIWISLPSAQARLSAGRDRMTNAESVYSRTVDEQLYKRPARGHAGSFILCTHKLAMRNNSIERFDCCRVRDPCIRPPGHHEGRRTVSAQGSAQRHPAGPAALLLDRRCVGRVMPVAGWRAAEQRPSRPSRRMANGVADLHRRHFLPLDLAMRVLNAATRSESDKTGRPMGAMVWRDPPGYGPRVIVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXR6</accession>
    <name>A0A6A6QXR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reduct</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_560529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXR6"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="403"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2497221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="652" mass="73425" checksum="6D297B342A2A0D53" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXU9</accession>
    <name>A0A6A6QXU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_526089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXU9"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="232"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2497039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="533" mass="60368" checksum="74C638668FB0EDB8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXV8</accession>
    <name>A0A6A6QXV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_560399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXV8"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31401" checksum="FD090A81C57AFA0A" modified="2020-06-17" version="1">MSSMLWWSTTREIRRRRTHLSRILYPIDFIPENHTEQVDLMEHFLKDVGHSMKCTHRRISIREDWRKSAPVDEKDLTKYLYYGSEHGWYYAAYHSFDEFGRKYNDENGHGPFVTEIFRWYWSLGKEVSTEQHQEIMDHFAVFKAWFNNHYKLNDLQSPFLALHIDTATPRYRDVYPGDTNPAVPGLRPTNLSAILGAPELAIPISQTPYQTRITGKEEQLPMVVGLMGPPSTDKKLIHWTLQALRKSGRATKVMTGPAAFETSSKKRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYM4</accession>
    <name>A0A6A6QYM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_459324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYM4"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="443" mass="49568" checksum="8FED32561D597EF3" modified="2020-06-17" version="1" fragment="single">GHLQTPSNVTRICRAILPEDRNHHPQIVYYQSGVGNGSTYLERLVGGGTGEGIGEHIREAYGFLANNYTPGDSIFLIGFSRGAFTARSIGGLIGGMGLLEKAGMPWFYLIFKDWENAGVKGYKPSILHSIPDFHIAAPPEDIKGYLSSYKSELLKRGLTRDVEIQAIGVWDTVGALGIPTTPLLQKVGLPDFLHEYRFLDTSLDNHVRNAFHAMALDEQRASYAPTIWEKPPYCTTNIKQVWFPGVHSNVGGSYDDTGIADITLAWMMSNLRHWIDFNPNYIREQHLLNQKYNSSQKPPLTRGWSLGKIYDSCTFPTSLGGREPRKPGTYTRTNYMTGQETSDPLEATHEKMHISVRARLLMEGKGYEDVGSYAPHSLSTWDMRNVDQYSGHATANGFDGKGAQWIYQGENPAFQGKVIFEDRLEEFELELLRMDPIAAAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYP4</accession>
    <name>A0A6A6QYP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_560552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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            <end position="19"/>
        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2497242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="265" mass="27056" checksum="73B07DA62D360BED" modified="2020-06-17" version="1">MYARSVLAAFAGLAAMASAYTTPVFQSTGYAVRTPGLAEIVPVGTPYKITWDVTKPEQKTVTLILLRGPSTNIKYLSTIVEDTPNTGSFEWTPAATLEPDTTHYGIQLIVDADGEYQYTSQFGISNPSYSKSSSSSSAVAPKTSSESKSAYPSSSSAIVSAASTPCSTSKAVVTPIYSANSTSAYITGTGTAYSTFVASTGAPHHNSSIIYPSKSMTVPSSLLTYTTGSAPSGTSASVPVGTGAAGHVKASLGLAGAIAGLVMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYW8</accession>
    <name>A0A6A6QYW8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2497645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="19238" checksum="990F2EA05950FB4D" modified="2020-06-17" version="1">MTVRHNKAKIERHVSQIRTTQKLLEFALSILTVKSLWRHDPQKSESNKATEMAQIKSTLSAWKDNAQKERENVLAEAQEVDENVDLDPDIADATAKELRLQAEICADFVAASDRASETLESVKLDQQIGNVNVGKGAVSHVGMPKSVLELQLVSRQHIGNVTVGDESKSEVGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYX6</accession>
    <name>A0A6A6QYX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_525016</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
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    </dbReference>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="356" mass="39597" checksum="F89F5D43F95E4AA2" modified="2020-06-17" version="1">MAYNFVRSYIDTFRERTAQISHQSTFRNTGQITPEEFVLAGDFLVFKFPSWSWADASHPSKRVSYLPDGKQFLVTRGVPCHRRLDDNFAGEAGQDETLVRDGFAAGEGEPDDDGWLRTGGMAASQEARVRDVRTVDESGNLGEAGEDEDEIPDMEDDDDEAIIREPQSGAGTAAPLRTYTLYICYSAHYRTPRLYLSGYGPSSEPLRPQQMMEDIVGDYKDKTVTIEDFPFFEAAIKTASVHPCKHASVMKVLLDRADAALKLRLAKLKAGKDVSKLDSGMEGLVDDTKLLKLTERAKHAEGEDGGKDKMGDEWEVLEEGADDEEVAIRVDQYLVVFLKFMASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZN1</accession>
    <name>A0A6A6QZN1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="392"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
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            <end position="289"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2497464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="567" mass="60638" checksum="21FF1EF05950FC22" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZV0</accession>
    <name>A0A6A6QZV0_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_526269</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2497250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="472" mass="52763" checksum="C19AE1AFD6ACBFFD" modified="2020-06-17" version="1">MPSKGVQVYSYISVPGYSIEYTVPAQAVTHTINNNFTSTHLEVESHNIPGHLNFTGRFEWKVVRDGEVVGSAYNDINTFTGNLEGGTMMSTQHFSPIMTDEVIITYCFYDAGHGHIGLTNRDQCYVTVCSTANRYWMGTLAPAGSPQAQKPFSRFVLAAPHDNGMNSMTTCDAIFSSANMDMISQLREIIPQVEWLSHISDAFILEHLPEIVYGTAITQKKEISVMLALGARYFEFRPAELLPTFQRLSKLPNKFYFQHACIPGIAFDDFLAQQVAFLDANPTEIVTLHLRYDNIVKQCRRPTAQEITDLLNEACSRAQNAPLTWGDRTLFSRPIESLRANGTRLIVVNEAEKYDSWTAEAYATLVPDPILARFEGMTTEGQESTDLTILQCQATSQSIKEVLVYSVLSANAATSCLTSTKASNDMVLLPWIRQNAVDRLRAERTIVVMNDFIDGATCDTTILLSRRRLEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Z7</accession>
    <name>A0A6A6R0Z7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_454993</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2498166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="31364" checksum="5761B6E63DAEA2D0" modified="2020-06-17" version="1">MASADPLDSALDLLRRLNPKDVKQNVDYLCQLAPSLTEELLESVDIPLAVKQCLKTKRDFLCCDYNRDGDSWRSPWSNEFQPPLDDGEGIAPSDRIRKMEVKANEAFDVYRELYFEGGISSVYLWDMDDGFAGCVLLKKAVSPSPKSNGSWDSIHVFDAQDRARTAHYKLTSTVILSLGNEAENLGTMDLSGNMVRQVEQDMAVEDDGSHVANIGKACGPIRETRFMVEDMELKMRNLLQEVYFGKAKDVVGDLRSIPPLSETNRDRATQREMINSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1N3</accession>
    <name>A0A6A6R1N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1709-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_525443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R2U1_9PEZI</name>
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        </submittedName>
    </protein>
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    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
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        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="303" mass="32125" checksum="4BC06B526069FF26" modified="2020-06-17" version="1">MSPPSGANDSKTPPIVSLLAGGVAGGIEAAASYPFEFAKTRVQLRSQKGVPTPKNPFLVVSQVYHSEGLRALYKGCGALVVGSIAKDGVRFLFFDAIKNSFADPVTGTTSPLRNLLGGMTAGVVASITAVTPTERIKTALIDDARTEKRFRGGLHATKVIWQEGGILGLYRGFAGTTLKQASATAFRMGTYNILKDFETVRDIPQTTATNFANGSVAGVVTTLCTQPFDVIKTRSQSAQGASTVEAVKSVWLDYGVKGFWRGTTMRLGRTVFSGGILFTSYEAVASVLNPMFAVVKEKLPIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3A5</accession>
    <name>A0A6A6R3A5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein family 31/32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_523711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2499215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="79235" checksum="694B199972F8D149" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4B6</accession>
    <name>A0A6A6R4B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_535931</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4B6"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="41293" checksum="62846DE8EBCF0D4B" modified="2020-06-17" version="1">MAGEEQGRSDRLGWILGNQGPRALPGCPMVVLRSRGEADRSSASAVGANRDRANWHAPAQIGAAGIASNCQEASRGCSTVLAITWQEVRNRTVNRGNGCCLTVRRLTKIRRPPAGRPALEGGLVAGGFQGWLHWVTGQNYFCCFLTLFAPSASCFRTWGQSLKCASMSAGQTRKLVLRLQRNVPRVHLGSTPGSRESARPTQPWQLLRLPRRLRLGEAAERSPSAAPPGTVVKLRELPRPSLRPPAVAVNSPGRSCTPRPPLPEMAAPSGEHRSSTRRLPSLSHLHLPPLHHHWALSLLAARPAATLRPTCPVGCQQAMLQEAVISTARRTPFDVPGLISCPAYHAHAPRERRRHWMGLEDLISPVLKAERPRVARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4C0</accession>
    <name>A0A6A6R4C0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_536329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="28024" checksum="A2779E7049FA3B5B" modified="2020-06-17" version="1">MLNPVMLEVIKRLDTALSEYQGAITQTNQSVASPPMRDRRTVTDNDGSVTLRRMTEKEVAEHERNGGKRRVATPPGMVEIETDNSRRRVTLRRLTEEEAERERNRKQTTPIPGESLRVKVDGDGGATLRRLTEEEAAAERQRARRERRDKAGVVSDGNGLEPFGCGLDGGTREKVTLSRIVELLALLELHSDFWWTARGLKASSSSLRSISITGCCDVGEAKLAIIDIPNCLKRGLFSDGIESIYADNHRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4P3</accession>
    <name>A0A6A6R4P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4P3"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
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</entry>
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                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="261" mass="29016" checksum="E7F1A9B685479FB8" modified="2020-06-17" version="1">MTYAISAAFATVLAGTHSPTDRCPYERRLLFNTKGCSGIPRSSFFGKLKRKAANMIQKCGPSSPQTRTWPSRTRRASIPRRCSVVSISGDWVGESPASSAGELVEASPGSEHAREEVPTHGLGAPPKGAGEEVYERSSTENKKRRSFSRATPSKGEDESFHLVRFARPRAPKVPWEPKILVGPPVMEVETDFWAEKKGGERRERKTFTDSWGSESEEEEESDSEGEDTRDVRNSQKKRRSIAAEIKQAMRETWTKAEELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R658</accession>
    <name>A0A6A6R658_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_579980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R658"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44851" checksum="E687E91E29944F22" modified="2020-06-17" version="1">MDNDNSSNTSTIDDHHLHTPPEETYIVDPEGDLRVSLYNFEDEEKATYLVSAPCLRRASRVWRSMLNDSPLDLKLSLPMLQVGDFDINEVNDLPQMDETVLLLFNIAHAKFDTLPETLRQIEIWTLVLLCHKYDTVELIRPFLRAWVLPYVPRVYSFHNIEIWPFVFWAMGYQNAFVSCAGAYATSYYSGLDDMSLQTLMPRSIYKALSLSTPMEALRGHLERVRERLFYKIQSTCDRYIDSLSSQKYPKANCVCGVEDSAFDCDSIALGSLLIIMRRDCLMSPNRGYFNSKISITEVMKALTRADLTTGRALSYETHIGCDVNERFHKDIECCLKNVDFLSNNLRRHFATFKLRKSEKNLPQWEAPEVLHLERKVEGDTEGNAPEKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7B9</accession>
    <name>A0A6A6R7B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_547950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7B9"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2499760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="267" mass="29798" checksum="62171DC9731DF928" modified="2020-06-17" version="1">MATETFLARLCEQAERYDEMVTYMKIGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSEKHVGTIRDYRQKIETELEKVCQDVLNVLDESLIPKAESGESKVFYHKMKGDYHRYLAEFASGEKRKVAATAAHEAYKTATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDGAEAEPASEAPKEEKAAEPKEAPAAAETTEEQPPAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7K1</accession>
    <name>A0A6A6R7K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7K1"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="31750" checksum="91654E8590C111A5" modified="2020-06-17" version="1">MAPDLNSVPASPRPAANSVSAPQQSSQQSSATTSRRASQIFPMSPPPLPLASPGGTILAASQHGHQPFPPLSPSLTGPFPSVDASGVPMRHPRPLTAAELHMECEKEQEAVVNRLTRELSNLRAHSASVASTASSTSNNPGLLLDTSDPATTHGPTHPTASRRHRSSSSVSRTSAGIPLNATTVGIPHQHRYSGAAQQERDARSASVVSTPRYEEVAHYKLELDDAKRENDMLRRRIRELEGLVRERRGSTSGSEVSRRGRSGAGERVAADREAAVNNGDGSANAPQEEESSTVILPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7U8</accession>
    <name>A0A6A6R7U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_453751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7U8"/>
    <dbReference type="OrthoDB" id="5387895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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        <location>
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            <end position="440"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="440" mass="48933" checksum="04EB8061F92F3C0C" modified="2020-06-17" version="1">MVVTTRARAARGQRSPTQQHATASSSDVIVSAISGIRYDVSALEEEVRQRVEAALGDDHHIRINYCVEREGDENEPDGYYAFRISDQISIRVGTDHPGYQVPKCSCGGNIGGIACKHIFWLEDQLANEDPETFRTGLIPLTADGSKIKNQSPSKVIDDIGLDEIAERKDWVLQDDAEDPEEEMTEMLSVFEPSRALASEMKEVSGQSSPGSHKSISPHSRIYKEFTDLITQYATEDIGMFYRIREIITPGFQAEVFFEKMSDRATESFQEIDETLARGPTAIDFCDIPTIAERLKRLVKGIEDGYAERVSGSESPSKQAAIKAAAALIDILEGVVDHNQDMTWTRLGDDDEPIQARNLFAYLIGAPLDSSSPFVLDVLKDLPQDVVVEYQKSRLDSIRAKLLSNHAPPPYMTLFRKIISQESKKRSNPEMGGSSAKKPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8G0</accession>
    <name>A0A6A6R8G0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_523518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2500756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
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    </feature>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2500756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="41293" checksum="8DBCC9D63F02B7CF" modified="2020-06-17" version="1">MNGVVVPRDHQSQAPRNSIQRCHECRRDFRHASHLRQHLENSPRHQIPPLSTYNHDANEQADPAPRKGSEDFTNIYSCTRCSAAFTEQELQAHKCSDSESDDDVNWESNDGSHECSECNEAFADLDDLIEHWSLRGCRICCDGCGDFVPKAQWKKHCRKHHACFHCHDHHSSRKLLLKHVRSCKPTNVDEDLAEISKLLAQSVLEDRDAPDFVCPYCLDRHMNETNLQQHLLTHLPVDEKCWGCERLFSTVPGIIIHLESGACPSATNKEELNGWAAEVFQWRNFIEKDWVRRLRNRVPVAPGDRPFYCDGCDTTFGSLSALFQHCANGSCSQGVSEGPLERLSHWLVTRLKQCQKDSRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8H2</accession>
    <name>A0A6A6R8H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_501602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64980" checksum="1E983C8FE37977C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8T4</accession>
    <name>A0A6A6R8T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_598634</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43640" checksum="CA2EB60B7FD480AD" modified="2020-06-17" version="1">MSKHVRHVHLRSYGEWNDRCSDRYLNMLSLLVRFPGLKGLELAILDDANGAFRSMVDDAQHSPSHFLKNLRHFSLRIDRTATDTELLPTLTYMFGHPNLRPLKVRSIRFKCFEPEHQNDLRTPLENLHLEACQIDEHQLAKILALPRALESFTLADEIPMEQNTSANLSTAAVVDHLAAHRDSLQNLCLWRDLDDQEANQNKIFTGQTGAILAPFNALDNLEIDLDTLIGTFADPDQLRKLADTSAWPAMLRKIAEDLQTTDELPMLRDLELIELHIEIYDVNEELEAIAMAEARAADDLDEEGEDEEQSENEDGTEDEHGTEDEDESDDADSASDGLSQPKVLEGNTDFKSIFKQTGKRLQVALTVEKLRYGDRGEHQRYLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8W7</accession>
    <name>A0A6A6R8W7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_536171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8W7"/>
    <dbReference type="OrthoDB" id="10479060at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58114" checksum="D8D8A23581B1AB3B" modified="2020-06-17" version="1">MNKPLLKLKVRRTEIAYEATTSAASTLDLPIHVVHTGTRTLTAHVYLRRNSSVALVIYHSNVATGFVDTKCPPNRLHSLSFSLHQLSSQHHHNYRHFRLPIMKHFLVNILPSFSKSEPTPLPDEASPALHIPELVEMIFSNLSQGDLIQCSQTWRDRRQHPATQPVATMRLASPKIVRKMLAAYGFGAPGYQAPVPADICPILLEGASDFNHVFSNVDTATTWDTPTTWYVHPREKIICISLAHDLSKRLLDHGFQCKTASCRDMFVMIPTRTHLVVRCRFYSPTRGTRFWHMTARSREWDMTAKISNPDGVHIGDLLDCLRDMEELANLAKTLEWNIGTALAAIYLPRLVPFLLNMGPHKLRRVFKYVRKFPSSYYGAKAFPCGTIDGYVSTLRYGYDILTHGNPYAKWQKVWVYAAHYLSQLDSWGYYLFLIYALCRMMSIRYGRYKVRGQPGSMQVERAMEMIVTFVIMSVYYYFTGALENPLKGPWILGEEARTAFRRRYKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R959</accession>
    <name>A0A6A6R959_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_190162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R959"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="104" mass="12242" checksum="700E7410B379805E" modified="2020-06-17" version="1">MRVCSYSARPRHRNSRIRHFRTCERDILRLAYSRCREHIRRVEQACVVGAYSQLCVSQHALPRVWALATHVISFTEYKDWSQPSSVDWKKGLSRKLMTAVIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA23</accession>
    <name>A0A6A6RA23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_522252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA23"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="237" mass="25474" checksum="CCAF3B8F45A5D1BF" modified="2020-06-17" version="1">MPTILITGAASGIGLAFLKHYLSLPAPPRIIAVDHHEIPPQEEAQYSPHTLDVSSEASLQDLSSRLKNTPIDLLIHSVGIRGLVPSAVAAHPGDVPATESIDAMDAATMIRTFETNTLGTFLVIRALLPSLRLAASPRVVVMGSRMGSLSYNTTGGGYAYRASKAALNAVVKSFSVDVPDVWFLLVHPGRVESGLVDWKEEGAISAEESVGDMMKLLEKEEMESGRFVDRWGVDIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA54</accession>
    <name>A0A6A6RA54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_534216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA54"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43368" checksum="AF97F973760AD0E9" modified="2020-06-17" version="1">MGSWDFYCACCGGGFKLWSALPPAEEWARIRKLLEEGSKQEVPRKKDENEEDGEEEEEDEAEDDDEGWLDCSICSHESTDWMKHLRLLGHNPHGKVGRGVFLTGLGYAQDYGSTEVEPGNHPNVLTADGPDVQTYYSAWDGKLQLSVYVNVLSTGDELIDFPLPFHDQCLQMIRRVISGKPDGEISIDTLYDAMGTARGGLGTERDPRPYNNSSLFLNYYQFAGAAREQYWGADRGYEPWYNDPIDIPAISKFLKNLPRAAPPREVKASDPAKDPFAKMPLELLVEIIMQLPQESLLPFFLSSRAARLASQSQWVWKKRILVDMPWMWELDEKKDYPEEVDWHAVYAKLDRLSFPEEWEGLKVSSGYALVFFDTGIILYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAR9</accession>
    <name>A0A6A6RAR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_500694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAR9"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2501534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="458" mass="50077" checksum="05A7AD6B3D897C26" modified="2020-06-17" version="1">MPPASARIPPLVRDKVSDHAKKTLDIVEKFVNEECIPADAVYSAQLGQGEARWSLPPIMNELKEKAKALGLWNMFLAKGHYKEGAGFTNLEYGLICEQFGRSRTASEATNNSAPDTGNMEVLAKYGSAEQKAKWLTPLLNGEIRSAYVMTEPLTASSDATNVQLSIQRDGDSYVLNGQKWWISGAGDPRCKLYIVLGKTDPNNPNRHKQQSMILVPSNTPGITIKRMLSVYGYDDAPHGHAHLIFKNVRVPANSMVLGDGRGFEVMQGRMGPGRIHHAMRSIGAAEEALSWLLTRANAEHKKPFGKLLSQQGVILHWIAKSRIEIDAARLIVLNAAAAIDTGDAKSALVEIAEAKILVPNMALTIIDRAVQTFGAQGVCQDTPLAGMWASVRTIRIADGPDESHLEQLGRRENKKAGEATDRIQTQLDKADELFRKYGTAPSGPCTPLNMREMVPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAW9</accession>
    <name>A0A6A6RAW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAW9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="66" mass="7734" checksum="307596C3F58982CB" modified="2020-06-17" version="1" fragment="single">MPPRNSRFWRNLLERVSNSSQMIIFVVCTLTAVLWAALLGMMIMTGRDRWNRGDGWNRVFRGFMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBC0</accession>
    <name>A0A6A6RBC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_449861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBC0"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="164" mass="19402" checksum="EEB8E697E05C3A02" modified="2020-06-17" version="1">MSLGPSEANVDSLTAEQQENFEDIEKQFAVKVVQHMEAYWSILEKMRGSTLRLTKLDNEIYEHFKEEFPDFDAKATINEDEMKSKAGKERWRNFINTYEEKVADYNFGTMVRANPKFEYAEKDEVIFAVRMQFYAIEIVRNREGLNDWIYEKAEAEKKDKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBK4</accession>
    <name>A0A6A6RBK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_476565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
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    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="20090" checksum="F2D43EBD1F7C23C6" modified="2020-06-17" version="1" fragment="single">VIQRVKSASVTVDGTLISSISKGILVLAAISKDDTAKDVESMAGKVLKLKLWDDDEGGRWKRNVMDIGGEVLCVSQFTLLASTKKGNKPDFRQSAAGVKAKELYQSFFKQVQELHEPDKVKDGIFAAMMDVTLCNDGPVTIQIDTDPPKMENPSGLDKVDLDPDLVGNLTKIVKEFQIPAELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RH37</accession>
    <name>A0A6A6RH37_9PEZI</name>
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            <fullName evidence="2">Argonaute linker 1 domain-containing protein</fullName>
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            <taxon>Mytilinidiaceae</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="519" mass="58525" checksum="9466ED81F69B60B4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8H7</accession>
    <name>A0A6A6Q8H7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15819" checksum="597BB5AF89674DB9" modified="2020-06-17" version="1">MDDALFVDNGIAARRPITFTRAERKIFFGGIFVSGAAGVFFFCWCKLGNVRSDAGVHLEPRSQPLSHRRMKSTSRLVLDFVPEAVYRASRYFNKRKTVMRHPRVKLYICALFRSLTYIHSQVSAPERSTAPPDDFVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q9C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="63" mass="7393" checksum="88E486CC9279D98B" modified="2020-06-17" version="1">MTFVAKRIRNLTFIALNIIFTVGLMLYTHFIFQFFTMLEYLECDSQVHGKQRWGWANGGDFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9F9</accession>
    <name>A0A6A6Q9F9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U-box-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_471806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9F9"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="306" mass="35226" checksum="7BD7FD4CE87860F0" modified="2020-06-17" version="1">MAGNDYAAEQLKEKGNAHFKKQEWAEAEACYSQAVTKNSKNPLLYTNRANARMKLERWQDVIDDCLRSIELLQENMKAYFYLAQAQLAIHHPNEAFTSALRAYELCVTSEKQTSNAFLISTLVLKCKKLKWENREKDRIARRGDLIAEVEGKLEADRKFHLSEIDGYVSDATMGKIEAEEERERINETYGKKIDDLRTAFAISDPEHMVKREVPDYLVDPITFELMHDPVVTKNGSSYERATIIEHLKRSETDPLTREILRVQDLRPNLALKQACSEFIETNSGWIYDCTEGEESPDTRWAHLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9K8</accession>
    <name>A0A6A6Q9K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_471995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9K8"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120969" checksum="8140E0386ACC5798" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA60</accession>
    <name>A0A6A6QA60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-binding loop region of homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_545130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2489001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA60"/>
    <dbReference type="OrthoDB" id="3946230at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.10">
        <property type="entry name" value="Homing Intron 3 (I-ppo) Encoded Endonuclease, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044930">
        <property type="entry name" value="Homing_endonuclease_His-Me"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46722" checksum="1558FFF2E9078138" modified="2020-06-17" version="1">MKRNAHPQYSDAKEEEVLRERVLLSMRETSAVVISSDEEEGQVSAGGLQKRRRGGSHRSDSSHDEEERLPRKRLRAAHDGVLRKSKAQQQGRGRSKILHSPTKVPQVGAYATPESSQETVAHSVLTAPYKPQWCEPEPTLRSESSQREYEYESPSILETYDSQSLLAADARQAIGFQAGQSSSQQSTSWHFLQPSPAVLATPTSSQEVSDPKAPGIPIKERKLYVLYKLPSVYKTKLLHLVQPYIDELPQERSEDECWLYTGSRFPKNCRTLHIHFSFWVDGKRAAWSMNVGTAVMLLKGQLNPVDKYILMEEEGSLSHRCGNWTCLNTRHHCIETLSNNQSRNKCFRLPACEHEPPCLKDLKVEPVHRLRPPSPETIRMRDSMKKYLQAKRTVPSSNELSHRFAQDEPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAD4</accession>
    <name>A0A6A6QAD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_575685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAD4"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="72199" checksum="F8E0B8CACCABFBFC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAM8</accession>
    <name>A0A6A6QAM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_520428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAM8"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2488673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="389" mass="43570" checksum="8AEBD9B3C522A582" modified="2020-06-17" version="1">MPVWDVFGRNKGKKPQKDEAPQGEKKPEEEYQHEPTEPPVPLFSTAGEHGLKTLAESDQDTVDIVFVHGLTGNRETTWTYNKTLYWPRDLLTKELPYARILAFGYDADVIRVLNTAGSNTIRDHGKSLAQDLSMRRIRTQSSDRPIIFVAHSLGGLVVEQAMLIARGSSQLYVKSLLPSTIAIAFIGTPHLGSSKADWARPITRLSNLLRKTNKEIVAVLSPGSEMLANLQQEFHTMIEDRRRNDGMWIDIFCFYEELSYPGIGDIVPRQSAILPDYPNASIHQNHSEMTKFSGEMDAGYIRVRDQLWLWADAVPKKKPEVAAAPVQSQIQSEDEPEPNSAPEEVDASQPREEDTRKTPQNERRAVSSGGGAVFIGNVNAGRDFTYNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAQ3</accession>
    <name>A0A6A6QAQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_544617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAQ3"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="259" mass="29715" checksum="6BA9BFDF24D29F29" modified="2020-06-17" version="1">MLISDANLDAMHTFFDDLWREVIPTLQPIHPPFAKKDTKGFKVSRNPRAGYTQLAEGDEDLWAYQNRHQCDKAAYVMYPVVVKVLGDEVEKVEIAYLWVEPVRLIEEWIDMDGERRRRHTVIVYTLKDGRKRVIDPSRSQFGIKDVKKSYHEYLDAYAPATPPDQPQLMTFGGYATFLRRGLGDDKSWLQELFFYKLLAANVTITYNKWEREYIQGGISAVDVLGGGQVEAKEGLSKAMKEVTLRVREMVDAGKASMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB45</accession>
    <name>A0A6A6QB45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_471864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8062037at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF81">
        <property type="entry name" value="OS08G0157400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="438"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="510" mass="54405" checksum="745638BEC5C63471" modified="2020-06-17" version="1">MTSQLRRRRSPLQGREEDQAAMLSRLLSVAAAATAASLMGDDHRAVSEARNVAGDGEDGTFDSFLQALQSGRIASALRQSSNENEDGANTPGAGPAPLNFFRMFRFGSSTTNRRNEGHMRSTSSRSSGMGSPESRASDDDGPDGRMVPIIIVGIRSINPGSGSPLDDNIPPFLDALSTFPTPLASPSGENTIDGILRQPQNSTRFSHRRRASLGGMNTFPAGYDSQRHHRSPERPRPWSTFTDSPSGPLPPPSTPASAGLSAVSSGTNTPALSAASTPPSVHSTVPSRRGSLARRPTGSSLEATAEEPQSQQRTPRQRRLSESDFTRFGSGASRRNGVVEPDHTPGEGARSWIIYVLGGSYPENHPILTTPSLFTDSPTYEDMLLLSALLGPAKPPVASEDDVASAPGLYWIRGTAGNLVAQSTDGFESIDISPEARCLVCLCDFEVGQEARNLIKCGHLFHRECIDQWLTTGRNSCPLCRGQGVDEKSADQSEVADADTLPNLRPSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBJ4</accession>
    <name>A0A6A6QBJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sister chromatid cohesion protein Ctf8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_544765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBJ4"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15767" checksum="73FA02A47B883FC1" modified="2020-06-17" version="1">MPSVPLHLPGANSSTLPAPNPLPTLLQTPSGLALLELQGTIHAPTAEESVPSADKSLAEIGKLVFPLYSELTGQEDTKWMKRVYLYVGKHQRMTGEVKKLGKPLGVLARRKAEDDGEELEILEVVRYKIVFSSRPEPVGGEVDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD53</accession>
    <name>A0A6A6QD53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD53"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="78" mass="7720" checksum="596328C6D17C6938" modified="2020-06-17" version="1">MSNPFNFQPSADRGRGGRGGCGGRSGSGGFTAGHGGQGRGSRGGSSGVPTGLAAARPAPTCLTRGRSGYGFRDCRDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDA4</accession>
    <name>A0A6A6QDA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_530784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDA4"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="147" mass="16691" checksum="5A4FAD562080DE2C" modified="2020-06-17" version="1">MASSGVTVAPECIQAFNDLKLGKSVKWIIFKISDDWKEIVVDEQSTEDDYSTFREKLLNAKSTWKGKEGLGGRYAVYDVAYDSGEGQRNKIAFISWVPDDSPQHPRMMYSSSKESIKRSLNGFHADIQANDADDIEYDNIITRVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDQ9</accession>
    <name>A0A6A6QDQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_531022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDQ9"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="769" mass="86056" checksum="B481F86674AADF8A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE62</accession>
    <name>A0A6A6QE62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_566328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE62"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="30320" checksum="6CA04532A61799CB" modified="2020-06-17" version="1">MSDERPEAGVCRHCDGRLSELTSTGEFLEGIRAANSDKEANELEERLLVNHRTLCECGDRLETEYREKEMEGLATEMANQARHFANLENLENQFDLASATEARRVSAMRQQARDNNRGAEEDEATIQYYQRQVRELRSSLGSLLQSFGSLVQGHQALVELHQSALEDIKSLQELAVPGVISAANYRQGLDPTALPASHPTARSSLLSAMPNITAQATSTPLVRSALHPLSRPPAASPGYPQAAPHIAGLRPKTLAPDKMLSQALGSRTSDADIADRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEP5</accession>
    <name>A0A6A6QEP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FolC bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_469128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="495" mass="54459" checksum="47AB39824D10A58A" modified="2020-06-17" version="1">MIQPGLERISLLLKHTQARTLHPWKAIHVAGTNGKGSICANASALLRRADVRCGRFTSPHLIDRWDCITIDDVPVKHKLFREVEDSYLQYNASENIKASEFEILTATAFDIFGRENIQVGVVEVGMGGRQDATNVLQAPLVTVISKISLDHQSWLGNTIEEIAREKAGILKPGVPCIVDHTNDEAVKNVIKTVAEEVGAGPILYTDSIEDEMKTFPGWGEIFDSILPHQRVNTISAYLAVRQTLQSLGLPKLEATEVAPGLKNVVWPGRLQKLQLEPVIKTETPILLDGAHNADSARVLGTYVDDKGARSYPDASFVTWILAITEGKDADEILRPLIKPGDAVVTVEFGPIDGMPWVRPTNSFKLLQTVRTICDGLSSERSCGKELVTALLHANYTASHVGSRKAMPSPNRPIVIAGSLYLASDILRLQRDYDPTDEHIMKQRNAFTRFLSFKEPYESDEEDSGPESDYDPERGPSIRGASTRGRGRGRGRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEV0</accession>
    <name>A0A6A6QEV0_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_622135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004197">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEV0"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
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            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="176"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="617" mass="68006" checksum="9E9A6905EC7D44E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF60</accession>
    <name>A0A6A6QF60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF60"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025660512" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="16804" checksum="8915B9307CC645C0" modified="2020-06-17" version="1">MRFFATLAFFATAGLVAAQTQSSAVMPKPTTGTCDAQNIVDACVSGIQPQITACGGNDWICLCQQYTNLLTCYNNCPNDPKGATVQTQVTSYCQAAAPYISASLSAAATMPHWSSSATASATANSATTGTASKATGTAAAASASSTGVAGVVVAPVGGVLAVVLGLVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFT3</accession>
    <name>A0A6A6QFT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_145876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFT3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="22431" checksum="58708C785DF2176A" modified="2020-06-17" version="1">MSSKATRLGSIAATFTQSADTSTVGFRSVGTEAPLQPTVLSRTQLAAVTTLPFAIAPRTTTASASCNISATDYAVAKPNFLSGLDTRKSDTITPNGIPKTNTVAPSASDNANGLYAISVFSRVDLLLDVSSCTSFAAHNRGALIGWGPFRRCVVGDEASGCSQVLAGGEGSCQAIAVRATAGTCYLLYKASTSSDLFSPIIIIHLIHHVHGLQLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG46</accession>
    <name>A0A6A6QG46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_530540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG46"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="63" mass="7387" checksum="1EA6105AE7116665" modified="2020-06-17" version="1">MRDVEASRRRREANERYFRRVNAGVLEVVEKLEVVARMMKGVELESKEIWRDSESVETGSMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGQ5</accession>
    <name>A0A6A6QGQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_115587</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGQ5"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="13">
        <location>
            <begin position="43"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="12">
        <location>
            <begin position="321"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2491279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="498" mass="55202" checksum="CAFBABEE6B667B57" modified="2020-06-17" version="1">MGEISGLEHLAPVTAAGTPFSPTFGASAAGSFTTEPRTGDPYRYQTGFGNRFATEAVPGALPPGGQNVPQKCRYDLYSEQLNGTSFISSRQSLQHVWMYRVRPSVAHRPLQPMALSPDLEACFAPQNPNVHYTPLTYTWGPLDIPEASQSINFYQGIKTMGGRGDPTIREGVAVHMYAANASMINEAFCNNDGDMLIIPQVGRLDIQTELGRIMVRPGEIFVMQAGIRFRVLLPDGPVHGYIQEIFGSHYELPEMGPVGTNGLAHPRDFEMPVASFDIDESKWTIVHKLTGELYCYDQAWTPFDVVAWHGNYVPYKYLLEKFVALSSSMKEQLDPTIYTVLMAKSKWDGVSLTEFAVFTPKWATATNTFRPPYYHRNMATEIGGLICGKYGGSAREQEAGGLTLEHSYMPHGESYEAWVKATTTPLEPMLVGVGSIGFMLHLSSHFSVTKFAMERHNTIKLQKPEFWDNMKGHFLENLAEVNKVLVESGLPALGTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGZ5</accession>
    <name>A0A6A6QGZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">BU16DRAFT_493562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2490903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="28726" checksum="07F4A098F940DE5C" modified="2020-06-17" version="1">MYELLLFGQLPRARHEQLLKILAGVAAMQPQRVLERHVVYRPQREPDEPGSNLRRGASQGIVQKQVKQTVARDLYFTQMVQTLTEEDFKEQKSAAPWTLQFNDVPDTGDKGVTVRMVSSTDFVEGDPHAYMVGFGNKVVSEYYVEGHRYVHKNILILLHRVLTEPGPQSAEQSPKPSLPTFDSLSSLDPSGTYILQASIRVVDNGSPALIDAGVEELKAFKDLLKGCVELDAPDRLLLDTRVKYQPKSFANLPPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHJ4</accession>
    <name>A0A6A6QHJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHJ4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="151" mass="17764" checksum="0B7132206B389D1C" modified="2020-06-17" version="1">MKRKKEKSEKNIITAIKALINNGEELTEDEIPEWHRPEWREWMKRRARSVERREGYITMNDQTSRKRKDKMNVSGSAYRAVPGLSWNKTNQGQEPLDRITEEKMNTDGVRRVQDGEKETKALRTATERSRIVATKVRSKPHINDLKEGPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIL6</accession>
    <name>A0A6A6QIL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_541875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3783962at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="30327" checksum="9BB23D84052505EF" modified="2020-06-17" version="1">MRQFSIVRFCASFVFLTSHLAISELNPISKPTAGEVLVAGTSYTIEWKPDIGSTVELQLWDDTYLGYSREFGDLCYNYLINPFCGQIATNVSNTGKYEWHIPHPSSYPRNEPYFWIKMFVNDFYHPELGNTDPVLSYSQNFSFAAEPGMSASSASLAMESSTSSVILPDQPTSTIGGFSTPFLSPPSASTVALLSASEASTADGTSSSSATQISSTSPSMTETNLSSQITTPGLITTTTAGEVSSTMSQSASAATATSNSGSVDKLIALPVLFQVSFLFCAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIP9</accession>
    <name>A0A6A6QIP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_565232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIP9"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31841" checksum="7C889AFC3A6A6283" modified="2020-06-17" version="1">MEGLGSQCYGFRESREPVEDLRQSRGSQRREPLDESHRRWESSRAFYQQALIVFSEDSGLHNYKPSKPSIDAPQVYSVAGLEYNEQSPPPFDECDIPVEKRILGLRKTTFWLLLTLALVVFGAAMGGGIHLPPPPTVTATRIPITITITNIFLCTRHLQTPRTLHYSPNRHLLPAASHAFIEHLLLHDTDGACAFRCTNGTSMSGYGVIAAIVTYSLQDCMDACSSMNHLTRQTLCVEFTIGADLGYAITHLQPAADCWLVASSTSSGGCEKCASGRLCKDEVGCEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIR7</accession>
    <name>A0A6A6QIR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_529341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="62952at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="338" mass="37765" checksum="F28D171ACAFDE31B" modified="2020-06-17" version="1">MPSSDPSTPLQSSSEDTVMTDSPDTSSYSPRESHPPLPTPTPRAAPPTMPSQLLALPRELRDRIYTFALTSASPFWYPNPTTDHNIEPNLLLTSRQVYAEAAPVLYSSNKFLFTHPSDCNMFRVVASPCSEHITSVCFRIREKDLRLWISYLSSSSETRSLHADLPRLKSLWIFLRCGSWGSPAMMFPAIQWAAQQPNWQNPFPPQHQHQNQPGNQPGNQPGNQIPVPPPPPGPPGGANPPAVVHNAGAAHLIDRFYRWDRDQGLENLVLSLQGKTHDAEVKIVAIQRLLRQDVRTLARSYPDDLILDKQGDARTRFKRVRGVEISLELSAVEPIQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIV3</accession>
    <name>A0A6A6QIV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_529521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036:SF2">
        <property type="entry name" value="OS04G0481300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036">
        <property type="entry name" value="OSJNBB0011N17.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34406" checksum="AB1722FAC1076332" modified="2020-06-17" version="1">MTRSSHSALIKPNYRPKPMPSPFTRRIRPAPILTISSLMAIPVALTAMSSSTPKAASTSTSTYPTIQYKPRHTTWPYTPADFLRQDLTPDTSFYASPRFVTHIDDHAIAALKRYYAAVLPRRGRILDFCSSWISHYPPSLESAVESGELVVVGLGLNARELDANPVLGKPGAPGRIVRDLNEDPDVSVAVNSGELFDAATCVVSIDYLTRPVEVLRSLAGVVRPGGRVHLVVSNRCFPTKAVRRWLRIDEDERLMMVGDYLYFAEWTDIEIVDLSGGEEEEESASGVAGLMRWAGMGGHDPLWVVRGVKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJR9</accession>
    <name>A0A6A6QJR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_565349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="799"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
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        </source>
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        </source>
    </evidence>
    <sequence length="276" mass="31236" checksum="661E672062BBC38B" modified="2020-06-17" version="1">MGDGQNDDAYDPWSVPFTLKPLKVGVCGSYEDGYQLAARLGDFFTILPRLWEDSVISHPPRPIEKEMLRCASTVVADCIREGAWLSVDDDDHGYELSKSEAGIRWAKVCARLFHCVHHNVDAKFREDFQEAMLFSTELEQLGVGTSDYSSVVMLCELYLLSDDLDHQIWWEELREVGSIFCVVLAKRDLWAYNVDICLDFFEYIGSAIGHDEDGRFLLRELAEKIRSTRGSKPYTEQQDGRIKQIVKRMLDTAAGGMELMEATGATENVTMSDAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="42"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="380" mass="43127" checksum="88192A9C8155DCC3" modified="2020-06-17" version="1">MPDFKKLARILSPRGIQTADNDGPSRFPPVPSVAPSAFTSSYILLRRLKEGESGDISLYTHQTSLQSIVMKPVKSVHPKQPLEYSILEICKHSPNIITVLGFCPHVPDPGTDAILLEYCKYGDLLEYQNLFVDNSVYPTERTMRVVFRQLLQALVFLHNGVGSGTDTSKWKPIVHRDIKLENVLISKLNEGPEGLLRDILEIKLTDFDLAKRYNKRDCIVPRGAGSPVCWPPEQTLQKRKAKPRGDIWAVGAVMHALAHCTYPLKDVVEYKEEFLRNYGGRYPADIGAEERNNTLRERWYWEALVPREVTSLEDAIDGYDGSGVRVDRNLPLWRLRVAEWRQVYSPEFSNLVASALKRKEERKTALELLGGMSNILNVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL75</accession>
    <name>A0A6A6QL75_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">BU16DRAFT_97163</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL75"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="410" mass="44435" checksum="4969D3989FBE0923" modified="2020-06-17" version="1">MVAQRSGDSVRRREIVDPFPARQQSPRSTDSKEQMRSMDIMERWLTETPKEEPWTPVGCTVGGSFQREFEPKPILRTAFENHGNARTNGRLARNGSSITSISEAFLRSNRAVSTIIKSPKIDRVPRITPSPNAPSMIEPTQTVVSDDSLLLTGGVATAQGKAGSLQAKSAPFLHVMGYVISNSTGFLEAIAIHQAHPGVHLPSILPVNSSERPLFQLDSVPGLIVVLCGPRFGKRFSSICPSSYLFQQCPQGSSSSSSSSTRTGSNFISSSPGGFRGSRSGLLSPGSGSCSKEANDDPSEETPPPPPPAPSATGASETPLFACPRQKHSADDCFYSVQGFRNMSEVTTHLKRTDHTIVYLCRQCNVYFLNASTFARHSQPPDALEPERHVAKSKPKCGSSYTCCFIRMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLI4</accession>
    <name>A0A6A6QLI4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_489674</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="30343at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
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    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="24420" checksum="8C4DE76229D811BA" modified="2020-06-17" version="1">MSSSKQGAYGAAGGAPGGDTSFRKTWDKDEYSAKGRDRDAKDREEGKARYEAHLAGKKYHRRASTPPDARDTEARAGRLDVASMVGKTTLVPAGSAVGKRGKGAGFYCEACDLTFKDNLQYVEHLNSKQHLVNTGQTGEVKRASVEEVHQRLLWLKRKREEESTEQVIDLEARLEVSKEREDKEREEKRRKRNEKRRKTKDGMGHVEIKVENDGVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLS6</accession>
    <name>A0A6A6QLS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_466381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5346581at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="329" mass="38034" checksum="D4C985D059211C0F" modified="2020-06-17" version="1">MWVADPHAPKVSVNDLGLEHRAALTEFLMKIFSTETAQETYAQIIEGLPLLRVFEECPNVTKREDLIAHEHLSSDSITIWKKFEDNFKVDILQFDAKTVQAYQNTVIGSREYKLRLLEMIAVACHSIAALLYKEVKGDAIPTERSLYQPPPITYPPSYDGTIRKPVARPPYLVLPTDFYHMSYQAIEQYPDGIANVVGYWAELRIFGGVVVFDRGESGEECKDAFLHPQPHRRMMHQLHDHQIDQLDNFKSVKREGSLEGVETMLPPLPFQNERYSRRLDEWEALGQHIFRDMYERRWDAPPPQRCVRSGEDVPELQDAVQKLRNEGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLW2</accession>
    <name>A0A6A6QLW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_563306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="267" mass="28046" checksum="CEE2E279D3CD3844" modified="2020-06-17" version="1">MAPQLLTGKVCAITGGVTGIGRAIALAYVSHGARIAINHLGDESSSKHFESMVAEITSSNKDIKAEDVLIEVPGNIGTQEVAIELITKTVARWGRLDVFVSNAGICQFAEFLDITSELFTSTVSTNLTGAFYAIQAAARAMSTQSPRGGSIIGISSISALVGGAQQGHYTPTKAGVLSLMQSSACALGKYNIRCNALLPGTVRTQLNEVDLADDGKRKYMEGRIPLGRTGEPRDLAGPAVFLASEELSRYVTGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN78</accession>
    <name>A0A6A6QN78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN78"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="80" mass="9001" checksum="05B5BBB092EF4B49" modified="2020-06-17" version="1">MGVPFEAFLPYGIMLGVRCPTRRLPEEKLEAHANADVRRLWSRSGAAQVHAERQQEEQTRTRCMGQAKYDTTSGAPRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNI4</accession>
    <name>A0A6A6QNI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_618936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNI4"/>
    <dbReference type="OrthoDB" id="10399786at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="435" mass="46423" checksum="04759F0ABC34093C" modified="2020-06-17" version="1">MEVIHARNPDRFLGYAGIHNGLELQQHILSLPGEDLDQLASFLRAIAQGKCQPSTSTIASQSSPIEEAASVLSPRRQGSNSVIADHCSTSLASNAASSKSPVREKESSGHPVPLAESPLRDTTSDTVKTKQSRPVWKGSVQFSLTEEDDGTFTAVAKGISRCDTGDTDSSISQPSASSPRSTLPDEDKNPNSTKLVTSNKPRYHHTPSFSINAQTIPTQGHKQEKFAGLAEALSNLKRSIPGTLGHSSKMASMALSILPSSGRGRGFFSSIQGPKSFIVGEEDNDGGPVYITDFESSLLPETPPGCDYPAAAAIEIASPDVENGEKYKSVGGQGALKAPQDLKGVKRSTKSKCSADKGAAEQVTNIARAGTLRLQDAVDAFVLQPGATDWDYRVRNPLKSYEDASKPITQEERDRHIADGFGPTYAEFLRMDPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNI6</accession>
    <name>A0A6A6QNI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_619162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNI6"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF61">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="329" mass="34888" checksum="DE92CA06A43E1E93" modified="2020-06-17" version="1">MSADVATQPLNLPLYATTEKCSGGTYIVTGANTGLGFEAAKHLVALGSAKVILGVRNLAAGEEAKAKIEAATGITNVAEVWELNLSSYDSVKSFAKKAIAELDRIDALIENAAVAGSQRVIAEGHLQSITVNVLSTLLLGVLLLPKLKESAKQYGIVPHLVIVSSGVSFDYKDGWAKIKDDPLVKADAFEDAAIMQQYPLSKLLEVFAIRELASLLPLSRTGVVMNLVCPGLCKTDLARNAPPAFRETIAAMHAKSGRTAEDGSRTLLHGAVAGPESHGCFLSDCKIAQQKVPSWVTDEEGSASQKHTWELIASELEATEPGCVKNILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP92</accession>
    <name>A0A6A6QP92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_511901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP92"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="280" mass="31259" checksum="8CEDBB4F2D9A8CF8" modified="2020-06-17" version="1">MSTTTPASASLPPAPWKSLFHKHMSEMKPPQFVLSTVTPAPPNSNSPTPYLPRARYCIFRGFWAELPENKHNEAERNPRVYETDCPAFTTDVRMEKVKDLFMSSAGHAESEAQVQGSGGGGPVEAVWWAEETGTQWRLKGRAFVVGPDVEEGDGEGRSGVRTLKSEVGKRMRVIDESKESEWSWARELEGSFGNMSPGMRGSFKGPPPGQPVNKPYDKDNLELGSKVEDLHNEAARKNFRVVIIVPDIVEQTDISDPNTARRHRYTYGANGQWTTEELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ94</accession>
    <name>A0A6A6QQ94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_424028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ94"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="16599" checksum="3E06F708DC0EEE15" modified="2020-06-17" version="1" fragment="single">RKKVWKTKVKTGCITCRIRRVKCDEDKPDCKRCTSTGRKCDGYEPPKAQKQDSQAVVRAARPPKSTRLSTSLLPGYARSTPAAFMDPAFASETSAESRSLKFFQLYTAPEMAGFFDSTFWVQDLLLAANEHQSIRYAVTALGALHQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQN2</accession>
    <name>A0A6A6QQN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_72944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQN2"/>
    <dbReference type="OrthoDB" id="3800261at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025504009" description="Chitin-binding type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="60380" checksum="317AF9D9C8911895" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRW4</accession>
    <name>A0A6A6QRW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_540128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRW4"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2494886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="39761" checksum="A2B13D8A1CBF87C6" modified="2020-06-17" version="1">MCPVCKSARYLNPDMRFLVNPECYHKMCESCVDRRFSQGPAACPIAGCKRTLRKARFRTQTFEDIKVEREVDLRREVASVFNREEDDFETLQDYNDYLEQVENVTWNLINDIDVEDTRRKMDAYKEENRRQITRNHSNAAQEAISRKAREEEDHELTRLRRADARREDELERQEKSDARKGIINKLATTKGDAASIAREGRRAELKKSSAQRVALDKKRDGDVFAAGTENGDAGSGFTFKGLKKRVAPPPEKPYDPYGGWSAEKEYFSQQDFYDWDYLSNARTDPRHSAGGYDINDYCARALCDAFSGFGVFIEDEVSGRDLGSTPSMATTAAAAVGGERVDAKMEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRX5</accession>
    <name>A0A6A6QRX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_550662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRX5"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="31370" checksum="C6EE9B71CB988CED" modified="2020-06-17" version="1">MKQRLFSSLRSLQHENPLGLPRSGAPPTVPRMQRGLPQQRSIRDVRKVIAVSSAKGGVGKSTIAVNLALSFARSGHRTGILDTDIFGPSIPTLLNLSGEPRLSSNNQLIPLSNYGVKSMSMGYLIPEASPVAWRGLMVMKALQQLLHEVDWGGLDVLVLDLPPGTGDVQLTITQQVKLDGAIIISTPQDLALKDAIKGVALFNKVSVPLLGLVSNMSAFICPTCSTSHPIFGSPAHIAKMCEDQKLRLLGEIPLHPSICVDADRGKPTVVAEPDSLRAKAFESIAKTAGELVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS05</accession>
    <name>A0A6A6QS05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_487698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS05"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="451"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="540" mass="57082" checksum="909ADB13EC545D2D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSE1</accession>
    <name>A0A6A6QSE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_527686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSE1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="542" mass="58957" checksum="47EC81992ADFC558" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSF9</accession>
    <name>A0A6A6QSF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_461453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSF9"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2495351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="38460" checksum="FDF31AF55E754858" modified="2020-06-17" version="1">MLIGLCGGICAGKSAIATYLIEEHRFRRISLARTASTPAVEKSASNAHVPTPKSDNDDGDASFPDVDALLDFVTLRWRERWVTTDIWDENVVDALMRRPFFLLVSVEAPVSVRWERFRSRCASHKLTPPILGEFVLRNDAHLYTPITGLAPLLHRAHVKLLNSTTSLTSLKTSLAALDLPNESRLRPSWDQYFMQLADLAAHRSNCMKRRVGCVLVREKRVISTGYNGTPRGLRNCNEGGCTRCNEGSHAGADLGTCLCLHAEENALLEAGRDRIREDSILYCNTCPCLTCTVKITQVGISEVVYNQAYSVDTKAASIFATAGVKLRQFSPVSSQELVPVRSSPHMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSK1</accession>
    <name>A0A6A6QSK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_527253</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSK1"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025332939" description="Coatomer subunit zeta" evidence="13">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2495391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="199" mass="21944" checksum="99BA842F3E0B9C13" modified="2020-06-17" version="1">MAPNLSLFSVNAILILATDDSSRVLTKYYDAPHPPTGNPSTYPGQIAYKTVKDQKAFEKGLLEKTAKQTSDIILYDNRICVFKTEGDLMLYVVGGAEENEILLYHVILALRDSLNILLKNSVDKRTVIENYDLVSLAVDELVDDGIILEIDPVVIASRVSRPPAQDMTSMQGIDLSERGLMNAWDFGKAKLAASLRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSK8</accession>
    <name>A0A6A6QSK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_388657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSK8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19056" checksum="1617EDF7A278BEAB" modified="2020-06-17" version="1">MLSRTKFQIPGLSAVIKLRISKNYLIVGTVPGEFTMLDLRCQHADVEICEHRRTLQVGRCWYSDCWGDTFATGYENRHIRLWDLKGGSSLLSLVTRINHPLSCSSTQQPSSVAHATANSVYGICRPAHASTPSVDTTQALGPSKPIAATCLHPAARTAPCGSGTSTTPSAHTYWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSS6</accession>
    <name>A0A6A6QSS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_572641</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSS6"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="346"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2495219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="393" mass="44088" checksum="609CFB1DD836A416" modified="2020-06-17" version="1">MGIKSLFQVISENAPDAVKTGEIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMNETGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKSEAQASHEEAKETGTAEDVEKFSRRTVRVTREHNAECQKLLKLMGIPYIVAPTEAEAQCATLARGGKVYAAASEDMDTLTFDSPVLLRHLTFSEQRKEPILEIHLDKVLEGLEMDRTQFIDLCILLGCDYLDPIKGIGPTTALKLIREHKNLEGVVAAIGKSTKYTIPEDWPYADARLLFLEPDVRPADDPECDFKWEAPDLPGLIKFLVEEKGFSEDRVKNGAAKLTKNLKTAQQSRLEGFFRPVAKTEEQQASLKRKNEAKIEEKKKKQKQAAKEKKATKAKPRQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT43</accession>
    <name>A0A6A6QT43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_618132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT43"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="214" mass="23870" checksum="07D6A7CCC18F6A9F" modified="2020-06-17" version="1">MSMVLEDVWVCQSCGDTNTLVLAPKRCPTCREIRFSGSKLEQDGTVRPLSQPETNRRSDLDAVWPGQYLALQKLPFESVRALGHGGFAQVDAFKMTDGPMRGKILARKVIRATGPQSQQGKQSVRNEIDLMKKLRHTHIVSFTFTYEQSLSRGKGLIFGIVIGTVADIDLAEYLDDMEDSIKNGGDPAWLLETQTASTYGTMYTPQAKYRRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT65</accession>
    <name>A0A6A6QT65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_561648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT65"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="621" mass="68237" checksum="DC86E1C6065C6EDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTT5</accession>
    <name>A0A6A6QTT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_561877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTT5"/>
    <dbReference type="OrthoDB" id="3796591at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="74983" checksum="6B29F57C49A60AC9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTU3</accession>
    <name>A0A6A6QTU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BU16DRAFT_485260</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTU3"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="290"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="528"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2495928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="724" mass="81189" checksum="3A66BAA4A2DA3143" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUQ8</accession>
    <name>A0A6A6QUQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUQ8"/>
    <dbReference type="OrthoDB" id="3599804at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18692" checksum="16B15EBA83B907D5" modified="2020-06-17" version="1">MSATSSPASSSVPRTMNMNNASTTEAVVKSFEGFLSFVIGLSIFGASTFAVIVSDIANPSTISENPQFTRKTVRTFLGIAWLFFILALGIVALAMSLLAVQREHTKAGFDGPWRRTWERLGLLASSFIQLLVTVAFLFLSLVLVAYAEAVGWVAVAFTSATAVFTVLSLAVQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVP7</accession>
    <name>A0A6A6QVP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_458090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVP7"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025470321" description="N,O-diacetylmuramidase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2496588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="223" mass="23638" checksum="E8D75478F89D19D6" modified="2020-06-17" version="1">MKSLFSLLAVGVGVAEAVVQGFDISHYQTNVNFGAAYSSGARFVIIKATEGNTYQDPSFSSHYTAATAAGFIRGGYHFARPDGASGTAQASYFVAHGGGWSGDGETLPGMLDIEYGPTSACYGLSTSAMVSWITDFVNQYHSLTGRYPMIYSTNDWWTTCTGNSKAFSANSPLVLARYGSSPGAIPGGWGYQTIWQYSNSYAYGGDADTFNGSLDNLKKLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX86</accession>
    <name>A0A6A6QX86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_459362</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </source>
    </evidence>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="119"/>
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        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="292" mass="32833" checksum="7B9C013E416937C2" modified="2020-06-17" version="1">MQSQFVAGGLRAQLPAIKQLFLRGQYRQCAAAAQMLLLEKSREEPCMHVSFLHFYAALSHHEISRNMRILNDQRQSSLELAEKHYLAALDSLSMFTTTTELETIDEVSDHSGDEESMAESCNPSNRSSINHKRSSLDSNVTDDTSVYSDDESDSAFPPTPKMFNRSPPSRNFLDDLTLPSQKLFRNPSLTSLPRPQIEQYNVNLTSFASMLHSHIYAVRSLQKAQAAEDSGNSISQGWHAVPNTSSRPRYSGTAKNGSKSGNFVRGRAKLLPRQRFDSRRYEDLCRKALAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R2Y4_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2499138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="19533" checksum="568855DD0ACCCB57" modified="2020-06-17" version="1">MLKEEGDEEWQTKGMKESAIEIGQAIDNDLKDFRWMWFIVAAESSKAATVQVVPVMVATHIELSAIQLPEQLSIHCLVMQLPFSLGTLHVLGLRAVLYKPMWVQTWKRESKNIYPGIENLALMLIKQIPALSIAGSCRSLKDFILSSDFEALVYVNHPDMSLNHIQYVTRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">60S ribosomal protein L36</fullName>
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        <name evidence="6" type="ORF">BU16DRAFT_263301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499205.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3D5</accession>
    <name>A0A6A6R3D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2499006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10252171at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="YTH_domain"/>
    </dbReference>
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        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="702" mass="77880" checksum="D8512D02C84F89AB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="552" mass="59384" checksum="A81C764D5F45D7CB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000799750"/>
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    <sequence length="400" mass="45611" checksum="8989EC1E3D065FDA" modified="2020-06-17" version="1">MVTAKKASASKVVKNNVKSCSDVTRDRVRSSLPRMFGTEMVTLRIGPQAEPFYVHKNLLTHWSPYFRGAFDGSFVEAETKSIALEDVQPWLFKIVMGWLYTQTLVLDKAAEELSDLKLAETSPFDQTLEEDVDPNRYAYVCLKRVHNIAQRNEFCDIIPKIREEMISLAKLEVRQTYNLEFLQQEMESLATMKHVPFSIIHGLKAMPTIFDIATAGADMLPGPIGPYIRGRAKEIYRRWYRVVNTRHGDDRDDTDSQQFSYNTLVDMYIFADKYDMPQLRRDIIDKVHFKNSHYPDSVPYLYAVLKAFESLPKTSGLSRYFFDVYVGDWNGQAILGGSGVKIGHLLPNDLLSSIATRRSKELFLLPGTVLSPMPYETSLCSYHEHPPNDEPNPTATVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R567</accession>
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            <fullName evidence="4">Secretion pathway protein Sls2/Rcy1</fullName>
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        <name evidence="4" type="ORF">BU16DRAFT_275143</name>
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    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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            <dbReference type="PROSITE" id="PS50181"/>
        </source>
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            <dbReference type="EMBL" id="KAF2499542.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="930" mass="104340" checksum="C31E5A812EEA88F0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5C7</accession>
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            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_535890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="293"/>
        </location>
    </feature>
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            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="831" mass="93942" checksum="13EA3630E4C909EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5P3</accession>
    <name>A0A6A6R5P3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025681144" description="Protein BIG1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2499879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="33870" checksum="C18B96BBC0318209" modified="2020-06-17" version="1">MALRSLGALALASASAVSAFQNTSPFFLFSTSDRLQLFDNANSQLLSANALNTYLKQSLAECAPSGTSETYIVVHQAGASTSDYQDDKSAPYLSGWLDGSDPQIKQKIVVPEVVGRTYPLIETVQTTLNECGGTAEWLNHKNVTDNTGKSYAGRVREGPQIITISYPALSAQNSADKLAEHDALLSDFIHNYMKDEQWTVIYVTTPRDAPEELATQAYEMDEPFPDNVNIELKRDVDSHEKERVLEGGLFEKYMFLSPANANLLGLFMGLTAAVPLFLILYVGISALTSLEVSYFAFSKEMGPVAQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5R2</accession>
    <name>A0A6A6R5R2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_452978</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2500088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00009">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="317"/>
            <end position="583"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
            <begin position="825"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="917" mass="97372" checksum="C45620F1BA326A70" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R643</accession>
    <name>A0A6A6R643_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligoribonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_452252</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="270189at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="187" mass="21105" checksum="28F028A0DCBCD1E7" modified="2020-06-17" version="1">MPWSKDPLVWIDCEMTGLDPETESILQIACFVTDYNLNMLEKDGFEVVIHHSAKTLDQMGEWCQKHHGDSGLTKACIASEVTHDQAATCLLDYIQKLVPKSGKALLAGNSVHADKAFLAKSPYNIVLDHLHYRILDVSSIKEAARRWAPNEVLAKAPPKLGLHEARQDIIESIEEARFYRDTFFKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R734</accession>
    <name>A0A6A6R734_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_253527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R734"/>
    <dbReference type="OrthoDB" id="10639407at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="18287" checksum="91D9DA4B1F838958" modified="2020-06-17" version="1">MLSGLLVSWRALLADGRAKAALFAAGGHGGAGENMASCFKMLHLVGKATRDPVTFLCCGSTRQQSAVPITARPFQHFVTFVEFRVRCAKQTDGLSASLSIASPVVELTLFARPAPPMLQSDMQPDISSCRSSAGCRSRLHSSIYCRNADARALTLCSSVYCSAINNIICDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7L2</accession>
    <name>A0A6A6R7L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_245103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7L2"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="333"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="823"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2500362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="886" mass="99149" checksum="CD7B07A007113901" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R864</accession>
    <name>A0A6A6R864_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_570144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R864"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="38573" checksum="1BCB671E81035A41" modified="2020-06-17" version="1">MFDFIADGLNTTITILFPIFASYKALHSSDPALLAPWLMYFVTLTLAHLLESTFAFILDWVPFYAWFRLFAHLYLVLPGSQGASFLYQTHIDPFLRDHERAIDDFITSAHERAKSAGFTYLKLAIEWAKVNVLGLPPQAPEPEPRRGVSYAQSLMGRFNMPSARADTDFYGLISQTLSGATAGFGGTTREAQAEELSASGNLVPPGLDEEQRASYLATQRNRLMVLLQAFDREQGSLAEERESRDGGYRGLAKSRSEVEFDRIERDEVEREGLGGRPEAGYRRVSGQPGGWMPWNWAGKKPVEPEDLAYGDVHAQKPSSREGGRSSGYDGARSSGYDGGRPSSGFLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8H1</accession>
    <name>A0A6A6R8H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroflavonol-4-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_535254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8H1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="38335" checksum="0690E1D183832182" modified="2020-06-17" version="1">MASQTLYQGSLILVTGVNGMIGSHIADQLLARGYHVRGAVRDVQKSAWLTEFFGQRHRGAQLSLVAVPDITVEGCYDEAVKNVSGFIHTASPLSGSTPEDTIPIASAGALNALKAAAKELGLQRVVFTSSSIAATMARPGVEFSIDATSFNEEAIAKAWKFPADEPPEMHGLYIYGGSKAQAEKDVWEWLRENKPHYAFNSVLPNCNIGKVLRPDKQGFPSIANWVRVLLFDPETLKGYEKVMQPQWYIDPVDDALIHIAALIYADVTDERLFAFAEPFTWNQVLAIARKQFPDRTFPEDIEGQEPDLCKVPNQRALELLKRMGVEGWTGLEESVKELGEQLVDFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8P1</accession>
    <name>A0A6A6R8P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_578232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8P1"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="41066" checksum="DFDE8D577BC9DC4A" modified="2020-06-17" version="1">MPMQLRPRPAANAATVANTQSQSKKRKRNDNDSTQPAKKRIVKTQGTKKMRAIAVKPAPWKPTGPFKFLELPRELRDMVYDKIFEDLPERHPWGNLVHDASEALFYPWRGSPMLAGLLGYDDVPIALNGPTAVLRTCKQVNEEAKEALYRDRIFIATFNEMKRRFGSRRQLHYDHPFQHIPSSAIDCRWDFASIRRLVILFDMGDGMAGEVNDDDGPNFEYSGDILLSTASFEALRTMPNLKELRIGMTYDSAAAPQLLRFFKGGDKAPYLLRNMMRSLIASIPKTVPVEWGLAEQDYRDMFWMNSAKDVREMQIFQWGTVEGKVLKGLADEFEGLRGTDIDYYADDADVEGSETSGKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R914</accession>
    <name>A0A6A6R914_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_556428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2499937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R914"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="182" mass="20061" checksum="3B51A8E0DC8E4F6E" modified="2020-06-17" version="1">MGASVSRFYSLIFAKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVIDSTDIDRLGTASEELAAMLNEEELRDAALLVFANKQDQPGAKGAGEISEALRLGELKDRNWSIVACSAIDGRGVDEGMDWLVQTVQSEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9H6</accession>
    <name>A0A6A6R9H6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_197728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9H6"/>
    <dbReference type="OrthoDB" id="5226911at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="447" mass="48585" checksum="EBF19AADCDE2E36E" modified="2020-06-17" version="1">MAHHHSDVSNCVDSIVHAFTDGFAVFRRLREKRRRKKSRKAGAGAAGVQLDARDGAELRLSNSLRRGPADIQTQYERSYGVVGERFAKGDAIAHASLAETLLKLNTGLVGIIASFLNHDRKDNLNLDYKSLTNLSDASRAEAIDTLNLLYQRLSQSNIALYQPKPGCPRCGSSKHANCGAVATRNSSEKSRKKQGGSSKSGSTTTSRSRSNTPTITRVPVKSSSQTQLAIVRPRNRRTGSTSSASSAIPSTKSPSTASTAVNTPMASPLASPEFRKVDPFAYPAPPSPPEYPSAKPTANSRRKMSSSHPDRPQTWPYAQPEPAPTPQMPAAKPVKATTFPVTAPPPPPKPKHLSPDATSKPLSAIPRRLDKATPSSYSFASDSTKLGEIPMRNWTVPFDYEVSGRLNEEALARGWPVEPREERERERPKRRLFGFLRRGSGDEKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9W6</accession>
    <name>A0A6A6R9W6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9W6"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="49358" checksum="27F492FD33A4DD8B" modified="2020-06-17" version="1">MAQSSAYPGLSFVNSATSKDLELDQETDSGFSHFERSCLDDEAPETEDSKSNVEEPIWNQPTEDIPDPTSSTDCSESESDSNLASDFQVDYDASSESLGIGADTPWVPSGPFRFLDLPRELRDNVYAELLTSENLNTRGTYYGYDNCRLHVWDREDAKRLGRVWQRENESDESDESEGSSVSSNHHTQIIFTAIMRTSKQIHVEAKKALYDLNTFSIDLTRLIPRLLNEAEHPDQTLPNNYIRLADHEPYQLGDELPGGLNYNCDPSAICRLNLQLHLWDAEGMSDRRTRPGLFANRNAFVGPFDVLAKLSLQGFHQMKSLQKVRISLAYDEIGVPTLVRWCKGDGPPPMRIRSFMRDLVAAVPEKVQITWGMTNAEAQKIVEESKWKGARMEAWWGFVAGDVLRKLADEFKCLKGMDAKFADEHAFEEIEEDLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA60</accession>
    <name>A0A6A6RA60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_204796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA60"/>
    <dbReference type="OrthoDB" id="3672650at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="48005" checksum="5FFFC4D2547CED87" modified="2020-06-17" version="1">MTSAEDPLPSKPRELLSLPREIRDEVYSWLAPQSPDHHRRIWLHLPLSRDDEAPYPRPTECNSMDASTPGLTKKVASAIIDVNDRIPKLYITRYAESDIGSDWTYDSSAYNDNAPESDVEEPSSDHDDSGSDDENVDEEFKLSRKNTEARVGPTEAKTCILDILLINHQIHQEFMESFSRQANIWLYVRMENTAEDPCTFTFDQRFWTLPYLRSVRRLFIIAEWHSRLGRNMWDYVYGPEDHPSYEIHYPEGRNRVEPLPQKLILQPKISKYDFPFTQNNFDMGVFPNQPPPLYRTVEIEDLPQPVSAHYIDRDCTGKEPSPPPRDMEALNAFCLDSVAAYKELGNIVDSLLERTTNAMGLDITIKTNCYEPLHSSVKYLAKTIIQDDVVARRIEETLVEGDWQDCLGWTDWEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAB5</accession>
    <name>A0A6A6RAB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_197075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAB5"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="247" mass="28159" checksum="75C6ED54F1D37716" modified="2020-06-17" version="1">MPPQQTQGLKRKLSQYGFSELGNTTVMVQVGAEAEAFSVHDTLLCSRSKFFAVALNGKWKESDDRIIKLPDDDPNVFRDYVAHLYFGKPSLDHYRPSNAPADYNAVSKLYVFAEKMQDPQCKNDITDWMLATVNPKEGDMLYYPAPSSIRTFYSGTLASSPARRLLVDMFTNHTVGSWLKDRNLDEFPVEFIWDLAVCMGQFRPLPSYDPLKRVGTKRYHEPVNQESRKENNETHTHELSPINGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAH4</accession>
    <name>A0A6A6RAH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis PhzC/PhzF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAH4"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="34838" checksum="0D0E932EB98146A3" modified="2020-06-17" version="1">MPLPSSHTRDLEYSILDVFTSTRFAGNPLAIVFLPPTADYNPSQSELQAIASEFNLSETIFLHQPTDSDITQAIQRARIFTSTREILFAGHPTIGAAAYLLLQNPWQHALKALVPGAGPIPISLVDGKAGFVKAVVPHTYHEHSQRCPAEKLLALHSTLAPFVGAEQTFPVVSIVKGMTWVLVELASLEALAAAKLGNAAAMIMGDGGLLDDGWEYAAPMGAYFYVRGPQGEGGEEGVETVRTRYMVRQIEDPATGSAASALTGYLSLKEEGERGGKREWNIVQGVEMGRRSEIGVKVKVEGGKIEEIEISGTAVVVSQGRIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAK2</accession>
    <name>A0A6A6RAK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_547327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAK2"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32627" checksum="480DF322DFA5C0D4" modified="2020-06-17" version="1">MSAGKESASFDAIIQESRKRKKNEALASEIFGRGKKGSGAGIGARKNPSQTPSLASRVGITKRSASAAPKPNVNGKWGHDLHAQNNPRARVAQLSRTASTSRIEQRSNRFVNDLRSDEPSPLSAQANIWGNATNGASGISIRGMAGPYTVIASNFAPGTTAADIEAVMAPIGGEMLGCKLASKEPTVIAEMVFVNREGADNVIDTFNNKKADGRLLYVYMKYGPPSQPTTRTPTGPSAQAQRPDRDAMDVDEQDRGRLRYDSQNNARDEDYSDGRYGFNENGAPAPPTQPRQNFRRGRGAYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAN7</accession>
    <name>A0A6A6RAN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_522385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAN7"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="330"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2501416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="51651" checksum="94E0AD0617B9D0D6" modified="2020-06-17" version="1">MESSALLHYPLPSDAGLKNQYVGRKISEVAAPAAIIDRAVAKRNCEAMLEVAKRLNVGFRAHIKTHKTTELSRLQVGNTGPASIIVSTVMELEQLLPLLRILQVEGRDCSVLYGMPLPPSNVQRLMSLAKKLKSLTINVLIDHPDQVEHFSQTSFKEPDTRIGAFIKVDTGYHRSGVAPESATLKTIVDGIMTADCLVLSGFYSHLGHSYGGNSAAEAIQGLIHEIRSTKEAVDLACEGLKVQNRLTISVGATPTATAVQNILMKSDPAADEARKVIEQVAATCHLELHAGVYPLLDLQQLATHARPTEVPGDLGESSNAVAPLSVENIGLRMLVEVASLYDDRGTPEALIGAGTLALGREPCKSYPGWGIVTPWEDSTAADDDRQLFFQEASPVYDEIGRTGWIVGRISQEHGILVWQGDQQNKRKLRVGEKLLVWPNHACVAGAGSGWYLVVDSDEQDPDRIVDVWVRWRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB01</accession>
    <name>A0A6A6RB01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB01"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="7">
        <location>
            <begin position="109"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="200" mass="21542" checksum="CE6C85C533BABA6F" modified="2020-06-17" version="1">MLNTPVTLFTAIPSPRTVQLTMTVLVPMNQYPAPVQSPDMTGQPPVYHQDPNAQFQQQYQQGQPQAQYNQSPPPQQGAYGAPPQQPQQAYAAQGHQQSGMSIGQQQTGTVYQSATPIANLGRGPAPADCPACGQRAMTSVSYEVGNTTHAWALGLCCLVCLGCIPYLMNSLKDVQHKCGRCGVLLATWHRSGTTEVHIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBG2</accession>
    <name>A0A6A6RBG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBG2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="369" mass="40551" checksum="BA6CFCC2EBEC8E48" modified="2020-06-17" version="1">MGDNFRSSSAASGTRFVDTSRLFSPHNHWPALQCLWDTQRVSLSVAPESRPSITFPHHPPAVKSQPSGHKAEILRHHRAETAHDTVIQLPEVLHEHPAARRRTAHWECYESIISRRPFAPLASRLSISAPSGGLSRPPRRTEQTPFIRACLANGVLLLDANRPIRLPSLRVTSLDLLKRAPAERLPCEGLDHTLSVRRLYTAVDYDLAASQSATPLPNPPRQPAQPRSAGLLAHELPGVDRDPPPRAHSTELDKRASVEQNRRSSLTARVPTGAGATALMPFLLYATRKEVLTFKGCRGRCFVRSVADGALPSAAFVPAVSGWGLHPSLPTAMQPLRGWCERGRCAPLFDDETHVVSENKKVEIREGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC39</accession>
    <name>A0A6A6RC39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_427321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC39"/>
    <dbReference type="OrthoDB" id="3943268at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="141" mass="16097" checksum="20E0B90E57651E23" modified="2020-06-17" version="1" fragment="single">FIEYLALAIYLTSGSPLRGEEVVLITYKNTIETGLRDLTIEPRLGLIRLNSRWHKMQNTTNIGSKSTRYFGPKLSNILKLYLLVVLPFYNFLSIKALGITTISPYLLEYNNSIIKSSSISNLLVKETKNFFKVGINISNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC55</accession>
    <name>A0A6A6RC55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_554339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC55"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2502269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="393" mass="42826" checksum="704C5865ED114888" modified="2020-06-17" version="1">MYYGLGNKAGRDFIIVILVFCGLSAVAVGLRLVSKRMKRLPLQLDDYLIIFSLLCVFCSVGICTASVTNGGVGRHFGTEVPLEDLKYTLKLLIPLQGLYGIGLGCVKTSLMVLYLRIFGTARKFRLTIYIAIVIVWGWAFSIVIEAFLLCRPFPSNWDPTVPGKCGNRNAAFVAAGALNMLTDIMVLLLPVPHIWGLQLQVGRKIGLMATFGLGIFVSAISIIRMKFLLSLNLEDATFSLPDPFMWSVVEPELAVVAACLPLMRPFFSKIARPWFGGSSSRGTKNSRSGLNSDGTKKQFSRLNDSNASRNKDYALETIGGGALNKISSEPSGYTVGVEGGKPYRIYEDGRSKTGVEESMQTLDDSDSGKSHVKIVGRGALPGGIRVQTDYRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC71</accession>
    <name>A0A6A6RC71_9PEZI</name>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="16615" checksum="AE1D83B28E956836" modified="2020-06-17" version="1">METETRHGHSHFLSDQPRRCENPTRFLPALDVSLLLCIQSLSNDIEGQFQLPSLLMSLLRDPPCDLLQLLAAICIAFFRFSIILPSFPMSFPAHDTFLCRPCYYTSTLHLGNTRSHCRRASRRLVITVASFVGGVIFSGTGVRQPIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCH5</accession>
    <name>A0A6A6RCH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_199391</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCH5"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="76" mass="8226" checksum="255B433270CD467E" modified="2020-06-17" version="1">MSPDLARHHIRLPCAVSRCQIYTSTTATASCSVASSSTMDCHCIGSAFPARGGKLRPAADVRRFIRVSTQFRLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD46</accession>
    <name>A0A6A6RD46_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
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        <name evidence="7" type="ORF">BU16DRAFT_532745</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Labutti K."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNF4"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="282"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502384.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="34805" checksum="7EEE7DEEA2C2BB3F" modified="2020-06-17" version="1">MSDSDPPPPSVHPRRRLPNPNPNFSTIRPLPHHSSSYHSASQSSSQPETPPFNDDYFQDAFSDFASAPAYSRLPHFDTILNPTNSSGTDRFFSPPAWPSPRRPPSPRAPSPTLPSIPAFSMSSARLPNGYVDLTHDPTSPSSPPPNPRRAPKRNTTLHSSPELNEGPSTKRQRRNDTTSSRIPATRDSPIEEIDLVDDDKTVLQNALQKQRMEQVKAQERPAEKPLKMSNLTCVICMDTPTDITATSCGHLFCHTCLMEALIAGENRSGVPEPRRSQCPVCRKLINRTKTTDIIPLLMMRGLATQPRKPATPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RDA3_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="239" mass="25787" checksum="0F41E7A003B1AB3F" modified="2020-06-17" version="1">MSPQEPTGSYMQWHATPSAGYEASNQSPSSSTHPQNPYDSSHGTAVTSYSRSLQPATSGQPYYTAATTPPVYSHRVAQSTPTWPHTSTQSYQTTASTPASHGHTRSQPYLSPGGHNPSSASPLAPPTYTYQEPHQQPQSYPVSEQPVHPFSVAPSYTSSNSYTPSSSATHVSDPQSHAYYSPYSYQHVPSIQLPDNEQHPDNYAVEERNANYSNSPSPSAASPGQLESKTPSRTNSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDC1</accession>
    <name>A0A6A6RDC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_612305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDC1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="295" mass="32649" checksum="0A3AB60B404D647D" modified="2020-06-17" version="1">MQTADSTGNTFVVHPSGQRTHYVEDDVDDPGAGAQKPKETVLIQHGFCRTTAHWQHWVPALARRFRVVRRDLRGHGRSSYPLESDGYDFSIDTILLEIVQTLDALGVDRVHFIGESTSGMLGEIFAARHPERLLSLTVISSPTHLPPQALELFAFGHASWPEACRAMGSRGWAEALSKVPGTVSSPDPVYIKWWIEQVAVSSGEGLAAYAQFLSTLDSRSYLKDIRVPMLIQAPANSAATKLPDQRWLAEQVPSARLEVVNGRGHEIYVEMAEECQRLFVEFVDGLGELDTSKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDK8</accession>
    <name>A0A6A6RDK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_554699</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDK8"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025513133" evidence="15">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="17">
        <location>
            <begin position="116"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2502651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="470" mass="51764" checksum="5986B0F8DD81F63A" modified="2020-06-17" version="1">MKYFRSLLLFTSTLSLVQGDLLASATKALPDCAIKCLVSAISVSSCAVTDVACIAHDQALELKVQGCVKEACTIKEALVTKNFTSSAFGAPIRDRTKDVSITGVTGGALALVVVGLRVIARLPCLGGQWGNDDWAILVAMLPVIPLTCLSVILANDGLGKDLWTVPFEKVTTILHLYYFDEIIYLTAIALTKISILFFYLRIFPGKNFRKCVYGVMACCVLYIVGFIPPVIAQCRPINLAWKHWDGEHEGHCINLNVEGWISAAVNIAIDVMVILLPLQQIVKLKLSRRKKYGLIVMFTMGVFVTVISMLRLKWMIQFANTENVTWDYVPIGYWSTIEVHIGIICACLPALRALQFRIFPSTAHASQYAANYYDTSKRGHSGYNTQASNASIIHSPAMKSERDKDRKGAREFVPLDDLCVESMNLVVAGKGGRPREIRTLGRAESDGGTRIVVRKEYSVAVEEGRGGVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIB3</accession>
    <name>A0A6A6RIB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_555218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RIB3"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9A1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="37930" checksum="369841C7390CAB51" modified="2020-06-17" version="1">MAPSAITPQSSPKLVAAPIANVVSPKYSDWRADLQKNGFAVVKGAIPKERAIQYQEDAYAWLKSFSTELDLNNPDTWIKQNLPVQSKINTFHSYCVAHEKFMWDARMEPGVLDAFALLWGTENLLASFDSLNITLPNRKDVPRKPAWEHIDQSPLRRGLHCVQGILNLSPSGPEDGGLVVYPGSHALNDEFFDTNTDESTWQPLDRYLFDEDQLAWFRARGIAPLKVCAEVGDLILWDSRTVHYGAEPSEKSEQIRTVIYSAYTPARLASPEQLALKAQAFESYSGTTHWPHDNIVPRDTKTFLEDGTRDPRDREQPLTLPERSDKLLKLAGVKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9S5</accession>
    <name>A0A6A6Q9S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LuxS/MPP-like metallohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_532358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9S5"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="233"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="418"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="813"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2488343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1105" mass="125940" checksum="1EA3BF5277651E9A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9U8</accession>
    <name>A0A6A6Q9U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_520083</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9U8"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="814"/>
            <end position="904"/>
        </location>
    </feature>
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            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="929"/>
            <end position="1022"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
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            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
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            <begin position="935"/>
            <end position="995"/>
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    </feature>
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        <location>
            <begin position="996"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115382" checksum="C2BF05F42317385E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA99</accession>
    <name>A0A6A6QA99_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_220059</name>
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    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="329"/>
        </location>
    </feature>
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            <end position="374"/>
        </location>
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            <end position="406"/>
        </location>
    </feature>
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        <location>
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            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
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            <begin position="81"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="581" mass="61852" checksum="8AFEBEDCC4AB9851" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAP6</accession>
    <name>A0A6A6QAP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_520189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="1460" mass="160269" checksum="1008DA1E139CDA00" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="840" mass="93821" checksum="CA07C3C4BC2C481B" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
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                <person name="Bills G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
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        <location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489007.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1395" mass="159632" checksum="EDD3EE6D575BDDEB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="8">WD repeat-containing protein-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_575463</name>
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    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCU7"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="38417" checksum="5728F934B084CCAB" modified="2020-06-17" version="1">MAAGSATPSAAGPPTQKVSEVISSFRPSRRFRPDDSKTSVTSLDFDDSGELAIVARDDDTLHIYNCKEGKHAKELKSQKYGVHLARFSHHAQSVVYASTKVDHNLRFVSTHDNSYIRYFKGHTDTVTSISLCPSSDTFLSCSADNTVRLWTLQSGNYQGMLKLHAPYLATYDPSASVIAIASPPTHSILLYDLRNYDKPPFATFDMQALEQRFLGRAGGGWSKLEFTNDGKSLLVGTTGAGHFVLDAFSGEISHFCYRKGGPSGRAAPGEGAAGGAPTGQGDVCVSPDGKSVIGGSGEEGLLVWDISKDPAADNVLHPTTDLPGQGRAAVVGYNQRHNLIVSADKDLLLWQPDPDAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCV1</accession>
    <name>A0A6A6QCV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_566256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCV1"/>
    <dbReference type="OrthoDB" id="10581514at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="439" mass="48762" checksum="16B287BD2F8A933D" modified="2020-06-17" version="1">MERRLSNTLDVLDSLQPFHTTPLNSSEIDAKVRARKNSGGAVESKGWAHLEKDKSSERENFPKGFPAEEGAFRAIEPITAWEHVLVFENGGSRTSTSTSPEDEGGKSYDPFEGGDMDELDGDTLNELDEAQDKSQVKPTNQPEGDVQNSPLSLPHTPPPQEPPRGLEADHPTQPQPTPRLRFFNPLTFLSTTNRAITRASLHVRAHLIGLNRANTLLRNNFAHFGNLLHLHAELFAAARREWLLTRITGNQADMLAINAETIHNLNGQIDGLTSLLDPLMESHRLREQLLARLREVETRNQQMEAQKAGERQSMLMAQQTILELIQENRRLAEVNEEAVQGFNRVVGENAGLRDARDEAEDRVQELEGETEGLRAENLEAWNGLAEMDGAYAALRETYAEAAGGLKKMVEEMREGPLDWTVREGFGGEGEGSGKKSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCW7</accession>
    <name>A0A6A6QCW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_434105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCW7"/>
    <dbReference type="OrthoDB" id="3943216at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="398" mass="42718" checksum="58B514CDBE1E5271" modified="2020-06-17" version="1" fragment="single">TFIDPIDSLDLQARDSPCPNSYESHNGLNFTMYCNQNNPWNDAQGPVQTDTMEICMELCSRYWGPTGEGCFGVVWNTGNSCWLRNSSTSTQGLYPEAGTHSALVPHAELKSVNTDCPFDNLSIQTVRNVENFTIHCDQVIGGFDACFDEYDVSGCYQGPYEGFWHADSLQECMEICADSHPLCQGVSWNPSQTIGFANCWPKTGWNNLQPATANMLIGVLHSAALTSIEPVNTTCPADKSYDTQGKTFSINCAQLNTGTNITSIHRANITACVDACAKSDKDCVGVVFDSTMAAGFQNCYLQNTTSVISSNANTTFALLSGTPLPTSNPTNTTVPTSSSKASSKAWIAGPVIGGVVAIGLIAGGIFWWRRRKARPVSGTTATGYKGAPGYGYSYAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD12</accession>
    <name>A0A6A6QD12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_531318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD12"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF79</accession>
    <name>A0A6A6QF79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Survival motor neuron Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_565862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF79"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22193" checksum="85C887F9B7A81484" modified="2020-06-17" version="1">MAPIVVDVDFNDRRAWDDSALVSSWEGALAEYKRYHSIHLEGKRVEDVLSSEELIELRRELGHEKEEVEVDKKPKKKRIRKPKASENDYPVADESVVPGETNGTKMEDQVRFDIPAAQSQALANFMEPTTSGQQQAHESADSSVPLHSTAAPASMPQVLLANVQDENMKNIMMAWYYAGYYTGLHEGQQKTTEQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFA2</accession>
    <name>A0A6A6QFA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_131633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFA2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="269" mass="29645" checksum="93C67BB63BFF1C91" modified="2020-06-17" version="1">MPLNYLDGSAGDRKTRRQEVRDFQPARTVIPSQAERAAPSRSLDTTREASRSHHENSQSRNTTREASRPHHESSQSQSRSRAHGSNSQSHARVREVLPSTSHPSGHGLAREVRPSASYQGSQPRRSERDRLPSSSMRRTVARAPTSNGDLKLRFQSKEEAVEYGRKLMEEGGKFADGFEIIHTTYATEDGKEVPGSKKRTKAEYDGSGAQLSYGVYGGSSATDRERTAQSKPSSSKYGGSSATDRERRTTQSKPSSSKYGGSSRYGSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFL0</accession>
    <name>A0A6A6QFL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_543433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFL0"/>
    <dbReference type="OrthoDB" id="10534768at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="387" mass="44164" checksum="15977BD5C2DE41C1" modified="2020-06-17" version="1">MAYASFELNLIEGLNDIPHDGPALILTNAECIFSRGEFRQLCRKATAISFLRRIELKISADGILSARDYLEDLGANLSCRDLEHLKLWLYTSKDLKTFRDRILLREPARYLLPTLAEVEGMVRQCAPNLATLSILIRESRGVTARASFRRHQDDGEWVQVRYLKPKKGFARLVKAVKKSIDGEVSLPLAHTSTMSAPFPSGPPPSNAEDNLDFIERCIETNVPVQVCTLSGYLRATGVHREQLSAFVKVYVDHDPRPYTRLLPLRHCCRLGKAELHYVLDQQGEQQIRRQQGHNRIHFRSLLPAPDDVERLIKSRSCKRLYEITVHMSGGEGVDHDSKTRAMRRRVFSDKWIVVRNPTSFLERNLSRARGAKLAIMNNLSEKFSHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFU4</accession>
    <name>A0A6A6QFU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_517833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFU4"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
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        <location>
            <position position="118"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="135"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
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        <location>
            <position position="167"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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            <position position="311"/>
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        <ligand>
            <name>a divalent metal cation</name>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="38774" checksum="CFF8ED6F6B6CEF1A" modified="2020-06-17" version="1">MIALGLEGSANKLGVGIISHPSPSKPPLILANLRHTYNSPPGEGFLPKDTAKHHRAWVVRLVKQAIRQAGVKVEDISCICYTKGPGMGAPLQSVAIAARTLALLWGKELIGVNHCIGHIEMGRAITHAPNPIVLYVSGGNTQVIAYSHRRYRIFGEALDLAVGNCLDRFARTLMIPNNPAPGYNIEQLAKKGKHLIDLPYAVKGMDASFSGILAAADILAAQISEDLDDAKRLKAEDGELVTKADLCFSLQETVFAMLVEITERAMAHVGSREVLIVGGVGCNERLQEMMALMAKDRGGSVFATDERFCIDNGIMIAHAGLLAYETGIKMPLENSTCTQRYRTDEVFVAWRDQDTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGJ1</accession>
    <name>A0A6A6QGJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="584" mass="64791" checksum="EDD3F2BF95196112" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGN9</accession>
    <name>A0A6A6QGN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_543431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10464538at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="168" mass="18557" checksum="3B25A28C1B217761" modified="2020-06-17" version="1">MASSANPSAPLTRGDPLSVEAVLLAASNRNLLTQQQAAVYLATPLAKGLQTVKVKILIDDLTCARDYLRLFESMNSKYIWELVIQIEYPADRDIMTLDLLPFREPKGPMTQLLATIGPNLRRLTITLVGFKIGIVQTTFADYERIGEGAWELDTKTLKHPLLPSTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHQ3</accession>
    <name>A0A6A6QHQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_552233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="249"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="46053" checksum="7E99C07BB0937A97" modified="2020-06-17" version="1">MSEADAWLAGVEALVEEATIDDDGSLSVVDSPPGQEVVRAAPDGGLRAWLVAAGSFCIWFSGLGFANSFGVFQEYFMTHQLRGKSPDDVAWIGSLSAFLQLAIAVISGPLFDRHGAWIIRPAAILFVFAVMMLSLCSGYWQFMLTQGVLMGTVMGFLMFPCIASLSQYFDKKRAAAMGIAVSGSSVGGIVFPIAFSKLLNESSLGFGWTVRVMGFVMLPLLIFSCVAITSRLPPRTSTFFIGSAFKEVNFVLIIVSLFFMFLGMWTPLFFIPTYAVSRGVDAAIASYLLAIINGASTFGRIIPGILADKYGKLNMFGLGGIMTGVVILCMNKAETTAALVVYSIAFGFSSGTIVSGASAAFSVCTNDPRDVGTYMGMGMAVASLAVLIGPPVNGAFVARYGGFLEMSVFSGVMCLVGGFTAIASKAATPEGLLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI71</accession>
    <name>A0A6A6QI71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_445732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI71"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="2">
        <location>
            <begin position="53"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="47308" checksum="33B75694B4A4BD86" modified="2020-06-17" version="1" fragment="single">KKPKKPRIAIPDYHLTAQVRDPETGEAIWPAPQTQIDRAKSFIQECVKAQKRTLIVPDKDADGLTSGVILHHTLTHLGLSPELISVHLVAKGNNVHDEAERTAMASYEPVFIFVLDQGSRKAPPIIDTEHRGLIIDHHFAEAGGFPENAVVINACECPPVVTTSLLTYLLCTQLHPELGAHLDWLCAVGTHGDLGNNLKWKEPFPNMNDMFNFHSRKAINDCVSMINAPRRAASYDVKPAWDALLAAKTPSVIVNSPTLKAARFEVNEEVEKWAHTAPKFSFDGTICVLRINSKAQVHPVIATRWAGYLKSEKLEVVMCANEGYLPDLVNFSCRITRSARAREEPVDIIRKLRDFAESSEAPDGLKERLGDNYARGHKEASGGVVGKKEFEELMEVMRIGEKPPKGKPYKGPKPISPNQTNLLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QID3</accession>
    <name>A0A6A6QID3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">BU16DRAFT_584697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QID3"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2491413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="351" mass="37289" checksum="1B7A334FBF742ACE" modified="2020-06-17" version="1">MAQKDPPLDETAWFSEDYARFYGGINTNTVHVYFYHSTFFDLASLNGTLWSQANRHYDQQHLLESRKAFEDAVKGVQSGGTQFLIVGEPESEDGTWVMQKQLRTVQRGLPDTIEVLGTYFIIGIQIFMAPSVGDVLAAKTLNITNQMSSFFTLASSLSLFTPATGHTYFHPSLKPSTDAKKLAIAGGVSRATTPGLNPTQDTASVAQTATGVAATSSAIGGTFIEPLFLQSLSLSTRYATEYADENPLQGEPGAFVFSSTNERVAALNEAAAQAALKAQSAAVAVVSAQQRERESAVSTAAPTPKPAVGEGSGSGRKGSKGGTDPTRVRRRKSKGLASPITPKEGTGQALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIF2</accession>
    <name>A0A6A6QIF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_529576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIF2"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="51"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="380"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="577"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="98262" checksum="4AE132CBC0C94604" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIK8</accession>
    <name>A0A6A6QIK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_529436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIK8"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="193" mass="20729" checksum="2DA311E3ACB0610E" modified="2020-06-17" version="1">MAKSFRAHLGIPDSTFSTTDSALLIIDAQNEYANGALTVTNASSSGAVIASLLKKYRDANGKIVHILHATPEGAPLFTPGTALAEEFKEVKAEKRDGEEVIWKQFPGAFAETKLKELLDGWGIKKVVLVGYMAHVCVSTTAREAHQKGYEVVLVEDGIGDRDIPGASGQEVTKITLLELNDVFGTVLKSSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIW3</accession>
    <name>A0A6A6QIW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_529533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIW3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17076" checksum="251FA15DB5BB13B3" modified="2020-06-17" version="1" fragment="single">MLNTNLPRGSYSPSPSRSTPPNQSSSRAHPLPSTARSLKRFLKSNEPQTFSPAQLPLHQPCCGHKRVVPVAEHGFHIARHAFEHDGGDGDEGAVFGRGGEDAVLLCEEERGGERSRLGAGSGADDNINLKKRIQHKNMLRVQIALHKRRNLHNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIY1</accession>
    <name>A0A6A6QIY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_529358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIY1"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCTHYDRLASE"/>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
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    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="293"/>
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        </location>
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            <position position="89"/>
        </location>
    </feature>
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        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2491966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="35304" checksum="2798DEE34274BA85" modified="2020-06-17" version="1">MSGGWNTIESDAGVFTYLLNNLGAKDVQFEELISLDADSLRQLSPIYGVIFLFKYPTGETRSDTPKDGTFDYDAAENLFFAAQTIQNACGTQALLSVLLNKTDEVDIGPSLTEFKDFTSAFPSDLRGDALSNSDLIRDVHNSFARSSPFIDETQRAATEDDDVYHFIAYSSINGKLYELDGLQPAPISHGPCTPSSFPEAVIPVLQRRIERYPANEIRFNLLAMVRDLRIRARDIGDVETLQQEEQKRTGWQWENALRRHNFVGFVGELLKGVVGSKIEEGEGKYEEWIEEGKAKTKKRVEERSKKGAGVDEMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ97</accession>
    <name>A0A6A6QJ97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_467223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="706"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="3">
        <location>
            <begin position="874"/>
            <end position="957"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="699"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="Pfam" id="PF23395"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2492104.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="978" mass="109176" checksum="02095A78CC9866A8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJE2</accession>
    <name>A0A6A6QJE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="322" mass="34735" checksum="150844686EA81512" modified="2020-06-17" version="1">MATATHSIPSDSPFDIPLDDMAALAASPGFQVLQHYLADKTDNSFCEHHSAFPDTHPTWLLHRDLLHALNMPVLQLFRRASALAHAALCTQKPEDLELAFHGDARSAFLWLQCFVTDEVDWCCTRGCPACVTAATISTESHIRLTVASSLLSISPASSAPSDALPISEPAGPTTPSGLSLPPLPHILPALREALAQDPFWGPEYWPYLLSRANSLSAGIQALIRECGELEALVSSPSPTSTPSEQRAALLRYGGLHGDGEGSGTKLKKSKLAKRQLRMKGEELELLQRAALQCWGAVAVPAALRKQTLGRVGERRVRSLTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK78</accession>
    <name>A0A6A6QK78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bet v1-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_529817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="150" mass="16518" checksum="C5B57B1B816F3342" modified="2020-06-17" version="1">MSIPTSTSVTESAVIEAPLSSVWHLIKLQDFSKFWSKLDKSEYVKGASDETDIVKWAFKDGTVLEMKQEEHSSIDHYITYSIISSQPALSYTSVVSTVRLYSVTSGKHEGQTFVTWTGNFSSDADAGVIEDAKFKRREALADLAAAAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKB1</accession>
    <name>A0A6A6QKB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKB1"/>
    <dbReference type="OrthoDB" id="3789787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="438" mass="49202" checksum="7C890967F1D54134" modified="2020-06-17" version="1">MSDLKDLELNDPFWQGGSAPFWPVGLSTTPYNGGQSGGFIAPNQDLQLATQILELDRIVRLQTDRIAALEAKVDCMEEASRMPSASHLYRPGPSVHQPQTPTAAPVVASSGPVSGETPGGIVSAPRSGTRADTPRLRHAPMLVPPGGANRQEYRPMLADYFGDVEKWVQQYATVPLSHIETTEALYKYTSQLITLAGVGDAAEQVLLASNYQQFAILSKVNHYICSKTMDCDLIDLFSSELETYNSVLCQHWNTATEYATCQAILRGRAELYWQMQEDPQYHQWRAGFVDKLTGDLMSILAPAIRHKSMEEARSKLAQFFIRAVRISIRMRMDQMSWVFNFPQQDDPLTQSMVFRNPDVSPLEVRANTQRHRVFFYITPKIQCDKYPARGPIGSEIVHGAEVIVKKVAISMWEPHPTQTWQPMSSGYSIVRKQEHARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKI1</accession>
    <name>A0A6A6QKI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BU16DRAFT_529025</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKI1"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="155"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="487"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="511"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF2492742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="566" mass="63286" checksum="E70DCC7E5FC55DBB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL55</accession>
    <name>A0A6A6QL55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_90487</name>
    </gene>
    <organism evidence="1 2">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="393" mass="43906" checksum="314BC1CD9087C061" modified="2020-06-17" version="1">MSNVVVGTIYQQIIEKVIQASQNDFEEFGVDQATLTEMREVWQTKLTNLGIAQFPWSPATVVQDRNTPTVPSNAPKQEPLDSPQIPSMPTQPVQTGYGGTRIKTESGYDSPVSATFQQQPNGFAGSGGYPNPQLTAHQRRDHILEQRYGVQSSNLSMGQQGQPGGNMPQPGQQQHQQQHPQQHQQQRMQMPGQQMPGQGQQGQRPPHIAQRQSGLYSAQNDGSGDALEEWSTLYAGLKAEPEDGPNGRHAADRLMRDQVEAMAQHQDSGLMVPLDELAKGRKRKATRRVRKQASPSEASPSKAPRIAQLDGEDDDEDKKEERDEDAINSDLDDPEDENDGGDDSNDENMDYMLCTYDKVQRVKNKWKCTLKDGILTTNKREFLFHKANGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN90</accession>
    <name>A0A6A6QN90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_465134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN90"/>
    <dbReference type="OrthoDB" id="5371169at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="79" mass="8237" checksum="75DBB040B4646AF1" modified="2020-06-17" version="1">MSSPLHDIWEAASASPYQPAVSKDSQFVVGAVLLFTAFILTGVFGLNRSIVTLPVLGVPASLAFGFGAVYMICAVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNF2</accession>
    <name>A0A6A6QNF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sec23/Sec24 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_619001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNF2"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="394"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="648"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="744"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="872"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2493772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112439" checksum="AEB7A762B79F1385" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNM4</accession>
    <name>A0A6A6QNM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_64929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="1"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNM4"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="490" mass="53560" checksum="B8594B09D9E9AB61" modified="2020-06-17" version="1">MVQHLLSLVVPQKHVKLVKTALEQQGKLNRAAKIRSISDDNASLGSGGRCSIPTTISTGEYTHFKENSSTALEDILGDILRDLDIGTAIRNISVTISDAETQEEHPINRNPLIAGIETWLSGLPPDLLSSLALTPSPLLSSFPGTYSVYPPLLLFPAHAFASPHWQTLLAALQTHPSQLNHLYASLAASVNTTHIALNAPIPPQNQGQLTSNILRSPVSLTPLYNSFGPAPTPSTQTVPSPADFEDAFWCSARQNGIAQTWAPLYTMFSRGNVSEKARVLRLPSVRSAVEDGSCGEGGTGRGCTAVDMYTGIGYFAFSYRKAGMARVLCWELNPWSVEGLVRGCGINRWSVERMVLAPDEEGEERGEVPEAEFLVFQESNEHAGGRIRRLRDRLPPIRHVNCGLLPTSRGSWRTAVVAVDPSFGGWVHLHENMAVGEIGKKAEQVTREIEQISRDEGRGDVKLEHMEKVKTYAPGVMHCVLDIWIGPRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPJ9</accession>
    <name>A0A6A6QPJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPJ9"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="431" mass="47497" checksum="2C33E2D556847087" modified="2020-06-17" version="1">METIGLRAQFLQGEAGSAKSLRQFAPTMTLDSKVKALVQPGPDIEWDPSVSTYEKRVATLAKQGLPRANEVPAGFPAKVDAPWVWSGADLDESKYIVKLDGTEIAEVEKALEHFKNLPGKLGVGDVSQETFPLPTLRPMLEGIAKTLHLGIGFSVIRGLDPKRYTPFENAVIYLGITAYIGEKRGVQDAGGSMMIHVKDLGSQIPNSELRQAPYARNPQPFHNDVCDILAMYVQQQAASGGESMLASCAKIYNEIAENRPDVIHTLADPSWIFDKHTTPAFWNKRALLFNFAGHGPGFCFSRRPITGSPTSPRSAGVPAMTEVQAEAIDMVHFTAAKHQVSMRLQPGDIQLINNLACQHARAGFTDSASEQRHIIRLWLRNENLAWKTPDGLKATWAEKYGDASEWRKVAKWSVEPGASRERVICRKHSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPT9</accession>
    <name>A0A6A6QPT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_529182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPT9"/>
    <dbReference type="OrthoDB" id="5329488at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025553121" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="25958" checksum="CF3C3EF0C89BA9E3" modified="2020-06-17" version="1">MSLRSLVVLAATCAIASAHTVITYPGWRGNNIHTNGTEPGSVDIIPGSLGITFDNGTLGFPYGMQWMYPCGGMPTSRNRTKWPVGGGAIAIQPGWFPGHSLALIYLNMGYGNEPLNMSHAMLPVFQIAGPTNVEYPGTICLPQVPLPANFTPAIGDNATIQVIEAAQHGASLYNCVDITFADPKDVEEVTPQNCFNSSGANDKISFNNVYTSALQSAGFASVRLNTYASTLAPSLFSLAAWIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQR5</accession>
    <name>A0A6A6QQR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_46992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQR5"/>
    <dbReference type="OrthoDB" id="10429110at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="257" mass="28306" checksum="D82CEBE901F70133" modified="2020-06-17" version="1">MAAFSRTAPRVFATRSAPTASTIRAFPWSLNRGFTSQRLAADQPSISRASRQVELEILKRLQGPENTISGAVSHDELTNLADLADLGRIKEIMDNPGGQQPGFALFRARHTVLRAISANSRLKVPILSPAQVEAWSEVVALDFDREDDSVKQTAQKTNKGFTKTIWEELLKDPPKPGESLRDFSARSMKQLDSHLPREEKSSKPTPDLPTLILIGFLAIPCTAATVALLDWLGILEPFKVNPAIKDTKPKTYDPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT88</accession>
    <name>A0A6A6QT88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_462070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT88"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="18307" checksum="FA8A48C557801FAB" modified="2020-06-17" version="1" fragment="single">MSDTISCELKISTELASRPFYKALSYTWGSLLPARQILVNGEPFTVRENLYQFLRTIHHEKPTFFFFIDQICIDQSNVQERNHQVNFMGQIYHEAIQVVAWLGPAADGSDEAMFWISRSQSHTSHYRRNDPVSLNYLFQRAYWKRIWILQEIMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTM8</accession>
    <name>A0A6A6QTM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_540752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTM8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="263" mass="27068" checksum="C07BD46FE543D5B2" modified="2020-06-17" version="1">MPAPFTAQTANCNPVLHAFNGPQPPPSALSSTTGGRSCFKISAGLDDAATCIRAGCVSPAAVAPRAPDLAAAASTPPAIARRRPSAACLGSARGPLSPDSFTALQPAFVAASRGAAGRRFTMHAMKLQKCAMYAPEPHAGGAGPSSARHHSINNLSNRANSTPARAMGDNKNKESAGKWANGAKPMSNSGQPCPSASCRQSVASSRMTRMHSLPSWPHLTVVGQGTPACQHQHVAGLFPALFGADRPQRLPRLGAGSAERVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTU7</accession>
    <name>A0A6A6QTU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_357865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTU7"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12527" checksum="EB1F01070E36ECB4" modified="2020-06-17" version="1">MSSFGGPGGGQKVFKPTPPERGSFPLDHDGECKAMMTSYLRCLRSHRGMNDPECRGLSKSYLQCRMERNLMAPDSMKNLGFQDLDAATTQDKSPTTTSQPGSSNTDATTQPTSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUM5</accession>
    <name>A0A6A6QUM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUM5"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="486" mass="53333" checksum="A0D769B64D4741C2" modified="2020-06-17" version="1">MGPKFFQDWALWEKMTFVLACAIGVTIFAGFCKLTYANWRLRKYDQADTAKALQTLELLEAQNSEEDLKTDEKEDVPFGIRAIESGIQIDGVWISRGNTPIGSVASSFDESRATSSRSESAQLEVPQQVYGSSSRSSSKAPSSAFEQAVSAERIPSSRSASSSSASSTYSLHHADIQPEIHDDIPLRNSSALLALEGLDSRKTPSLVEPNSSSSSTSSATSSHDSDETDYMAIPRLQIRRPYEPAYIKPSISPVLAVDSKWNLDLLQSHRLSHVAETGQLTPRIRRPVGSSGEWSSIVVPTRNNEVALSAVEQFTPHQKSSSLPLPAALDMFPIPPQRASVPPLTKEGQSLYPASQIISPPNTYRPRGEQSDPEINGLSSGFPSARQANDSQYVQHTYQPYESPVRVDETEQQLNPATQQNRRDAQVLRKVNSGFEILRPGTFTFADEPTLHDTGSSSGEKRQSRRLRKKRPGSSDYGASSFADNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVU8</accession>
    <name>A0A6A6QVU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_539062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVU8"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="24561" checksum="2BAAF2B456DB58F6" modified="2020-06-17" version="1">MHRGAAATDPRDKIFALHGLASPGQTHGIGPDHFFSKKQIFLNFTRRMLERGENFDILSLAQGCRDCSLPSWVLDAQPDPSSSIDAKQSFAWSADMLPSLGHPRFKASNSSLSRPIFSNNETELGILGMELDVVVRVATHPGHRVFPGINLSSSFRQTLCVDWRNNSRHVLEDECRGGRSLDGCVPFSALRQSTVVLSSDYKTGSRRRILDLLYYVWAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWC3</accession>
    <name>A0A6A6QWC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BU16DRAFT_560076</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWC3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="1048"/>
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        <location>
            <begin position="50"/>
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        </location>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1092" mass="118949" checksum="3A563B37B64B0C61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWM9</accession>
    <name>A0A6A6QWM9_9PEZI</name>
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        <submittedName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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    </dbReference>
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        </location>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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    <sequence length="448" mass="49870" checksum="0B898636A89D0C0B" modified="2020-06-17" version="1">MAKRRVKKRTQPAPSDNGAVDRSPKSMVIRIGAGEVGSSVSQLVKDVRHLMEPGTAARLKERRANKLRDYTTMAGPLGVTHLLLFSRSDTGNTNLRLARTPRGPTLHFRVEQYALCKDVLKAQRRPHSGGFEFQTAPLLVMNNFITPEAAVAAVEKNGVEGETKQGPPPKHLEKLVTEMFQGLFPPISPQTTPLTSIRRVLLMNREPLTKEENGTYTINLRHYAITTKVMGLPKSIRRLNAAEKLKGSNKKRSALPNLGKLDDVADYLLDPDAGGYTSASETEIESDAEVEVLATSARKILSKRDRAAAPERPDGHKSGSRGGKGKVEKRAVKLVELGPRMKLRLTKVEEEICGGKVLWHEYVNKSAAEVKKMNATWEKRKREKEERRRVQKENIEKKRKEKGGKKGEEGEDEDDEDEEDYDMDDDVWDEDAEGDGDEEMEDGDGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWR8</accession>
    <name>A0A6A6QWR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
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        </location>
    </feature>
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        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="179" mass="19151" checksum="4472EFDD94DCEC64" modified="2020-06-17" version="1">MDVYYFYTFSTAGWMALQAAPLILSPTIIVAMLSPEVRDPSILEVYFSRSLGFSLITIGILAVLLTGSVPLSSRLTEAGGTTTDPSDPKAPYAVPTLMVTLVFHTTIAFYTYALWTQTGVTSFALGTTFSTLLAVIGGWVILFGSSSGRISRKTGADKRTSGFPFKNAEASKRSGKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX71</accession>
    <name>A0A6A6QX71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_347857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0V9"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025420318" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="38506" checksum="D03A14244F56F71C" modified="2020-06-17" version="1">MRFLEASSSLLAFVALSSFATTALAKPYPAHLPELARLHNVTEQPLELRDCANPCGYYGQLCCASGESCFTDASNQAQCGAAVTPAVTAAATTGGQWMYYTSTWVETGLVTHTSVYSSYVGATAAATPTGTCTGAQSPCGSICCDSGYYCLTSGQCALVGAGSSGGVSGTLTPSAPLRPTSSGLIIVTATGTPTTTVPFSSPIATGVNGTMVPVASGGGGGLSGGAIAGIVIGVLAALLLLLLLCFFCCARALFDTILACFGLGKKNRKHTHEETYIEEHHHSSAAGGGGRRWYGDRPGRPKPPKKAGGGFGNALGIGALLGGAAIALGLKRRHDKREEQKSEYTGSSYYSDYTSTTQVLMIDGHEIHAIRHGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Z8</accession>
    <name>A0A6A6R0Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_286852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Z8"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="285"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="387" mass="42055" checksum="D35DEED4E89E5BA5" modified="2020-06-17" version="1">MQPLYPSQEILQNVFSASSPLTLHKTSSTPKPRSKYEAPRGVFNTWSAIDDAKNKAGQLSNAAIQELGKGSAKAQAKAGNIEMYSMQYYAACTFGGLLACGTTHTLVTPLDLVKCRRQVDSKMYKGNIEAWGKIGRAEGFRGIYTGWGPTFFGYSAQGAFKYGGYEYFKKTFADLVGPENAYKYKTVLYLGASASAEFIADIALCPFEAVKVRMQTTIPPFAKGTFDGISTITGKEGFAGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYSYLPGTKADYSKSAQIGVSFTGGYMAGILCAIVSHPADVMVSKLNANRQPGEAFGGAMSRIYKDIGFGGLWNGLPVRIVMIGTLTGLQWMIYDYFKVFLGLPSTGGPAPPPKELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R143</accession>
    <name>A0A6A6R143_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_536531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R143"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="415" mass="44034" checksum="539F169F7BC80186" modified="2020-06-17" version="1">MTHPEHPIDTPPRPASPVHGFGTLAVHAGSPHDPVTGAVIEAISLSTTFAQTAVGKPVGQYEYSRSSNPNRDNFEKAVAALEHARYALAFSSGSAATANILQSLAGGSHVVSVSDVYGGTHRYFTKVALAHGVQVTFSPSLELDIAELIRPTTKLIWIETPSNPTLSLVDIRAVASVAHQHGILVVVDNTFLSPYVQNPLDHGADIVVHSVTKYINGHSDVVMGVAAFNSPELFEKLSFLQNAIGAVPSAFDAWLAHRGLKTLHLRAREATTNATAVALALEASPHVLAVNYPGLASHRHRAIALKQHRDGMGGGMLSFRIRGGHEAAERFCQHTKIFTLAESLGGVESLVEVPSAMTHGGIPREQREAAGVFDDLVRVSCGIEDKDDLRTDVLQALEKAVVGGIVKNGVNGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1G2</accession>
    <name>A0A6A6R1G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_559412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1G2"/>
    <dbReference type="OrthoDB" id="3685234at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="506" mass="57450" checksum="EDA0DD9BD8A1D109" modified="2020-06-17" version="1">MSTFSGLFIPVELVYSILDLLPSQSDLASICRVSKEFHSVVSPRLYQSPVVDCGIYINARNAAVWPFLRTVVRRSELGACVKKACFSEHYYEWTYYKMEKETPDIGSEDLELTGTLIVDANLPNPQDWIQAVKDGDPDALIALALCRLSNIEVFEASINSSRQRTFIGIIFEHALNSIRSFPTCFPSLSNIREISVSPKGVFTPLEDAYPLFKIPNLQQVEIKIREVSEWYALHAREISDKSGPNWVWSPFRWPQPNVEFPTIKTLILRQSHLSVTAMRILLAALPNLQELDYDFWGKGTMDYYEPDEAKYPGWLIFGCSPNQRLNFSDGFQPLQDQLEVLRISATVGTGTDDFFDPPPASESSVSTLRQLKALRILSVPLSILLGWDPLAGGTLTQILPPNLEDLEITDTFCDNWDYYWLPQDILPRICDYLTSSSATKLKRLSLGRHSNGHGWREGWRDNDIFDPVRQLCGERGISFIYDLSCHCDEPTKCKSASLYVEDLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Q7</accession>
    <name>A0A6A6R1Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA methyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_456235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1Q7"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="52318" checksum="B3727FDBCB32F6EE" modified="2020-06-17" version="1">MAVPFQCVQACRPDPQDHSSWVLLAASGPRIYSCHSSGATSVWSSQKISEPPVHADEPQEPPGKKVKLSKQAEEPPNVSKLVVTSDYQHLVAVTAEDKCLRVFRLDLTGRLEPLSERPMPKRPCAVTLIENDATILCADKFGDVYALPLVPSPTDADDIFVAAQEKKETSASFVPTATPLTVHSGRNRKALEDQLKQKLQPKTKGPLKFKHDLLLGHVSMLTDILYAEIAGEKAEAKPRTYIFTADRDEHIRISRGPPQSHIIEGFCQGHREFVSKLCLTGSGDLISGGGDDDLIVWDWLNSRMLEKISIKQPVLDFFKAHPQHARPPQESEGDLKVAVSGIWAIPSSSSRDSVLVTCEGVPALFLFKIDSEKKVSSLQQTLPLVGNPLDLTLLESGQSTEVIIVSIDHTREPGSTTMLRQKEVNVILEQLNDQAQGDGLLGREVEVANAENPGKQAALQDIFYGIENLRKRAGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1T2</accession>
    <name>A0A6A6R1T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_301923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1T2"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053105">
        <property type="entry name" value="Class_V-like_SAM-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="136"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="35357" checksum="8964174142E972AB" modified="2020-06-17" version="1">MSSGNRVIWHKGDDPKASFPVTPTAKVVKTTKKKGATTKKKAATTKAPAQMDYYRFKKAEWRANRPTNWPVTPPGATSTWPPNTVADLLVADTPEGDPSRPLCIGPLLWQRIDCGDVQNCRHTFWEWIQGGIDWESRFELRESPIAGIGVWTKVRWENNDILGCYTGTVVPPQFSDREAATRADGGSKYIVKMAIGPKPPRLQVRHSAAWPKADIDAEWFGNWTRFANHSCNSNAKFVPRRVGNHLVMVVQAKKRIPVGAEITVAYGKEYLDAMGTLCLCGHKDCKDRAKHKVIKAAADAKAAKAVSRVAKAATRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R267</accession>
    <name>A0A6A6R267_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_558836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R267"/>
    <dbReference type="OrthoDB" id="10392230at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="14"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="273" mass="31210" checksum="9E3041E18C1F7311" modified="2020-06-17" version="1">MQPRLSLAHPRFSKLHEHLATCPESMVLPRYGKLSTEIIYEIIDDFDEKCKEFEEARDQLEEFRRRVVHVSSAANPEAQIQATEKEMKEIESKLKRLKTERRDLWFMYHNALDSYGKTAALPDPIKFNHGNFHEEVNNCDPDAEIHSVYGSLGSIIDRDLCTLKGYPPMDPFSNLIIFHILDRLSKSKRFQRFFKDKSTQKLGVVAGVVTKATHVINSILLPLFLAGSIIGLFFVESMIARLAVIVALLLVFSFAAIFFVRSGRNDMVIFMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2D5</accession>
    <name>A0A6A6R2D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_309538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2D5"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="100"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="456" mass="50463" checksum="771150EEFE6B92E2" modified="2020-06-17" version="1">MGISPSATLVFEALRLLLFIYSTSAIIVRLPVHRDAIVYTLPCFPVAKEQSRRHTSKGTFDTPRLLANDQAQKVLHGAPNSYSAAAGPLHECDVVYHLLFTSNVTLGTPPQPFIARVDINWADMFVPSAPCMRDPDRDCAPFHKLNSNQSSTYIATTTFSAIDYEGLGTSGHLAQDTLSIGNISITNQTFEAADDWRSMYGHGWAPLDSGLGLTRFRAPRRHPESGYGNWPLRNMIDQGLLDRNVFSLRLPRTGNDVGELILGGVDDKQPKPIIKLPLTNKTFISEEQTTLSFLASSGWQADISGMSLQCDGQSDHLFDVDLQGVIAVFSNSFDFISFPFDIARAILDTLGIEDEALPDPPCERLSDLPNLTFAFGEQGEITLAPRQYTIRVQSPYGGERCIIPFTSWAHNDVPDEVEGDYVVLGTAFLNHLLTVFDMDGETISCRFRVWGLVRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R366</accession>
    <name>A0A6A6R366_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_548148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R366"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="41863" checksum="FE7FE072491E3B30" modified="2020-06-17" version="1">MCSYTGCFPKYEYANSSHDDDDALLARLNALKRTHVEVSSSPSIASPSASTPPLKDEDDLAARFRRLGGTNASPGITAPTIAPGAATYLEGVAEGLGRDSKHNDEDERSLEELLKELGSGSQWDIGGKDQGDLGKLVQEARRILPELNQTREHARGNGESRGGDAEVKDEQVPHEGKNGEDDEVEDAMDETEADEYIAQILADLALRKKYGGGEDQDDASNNGGEHEHPDSKAANPEKTSDDDNKNPKEATSPSRSSGGDLELPAAPSTQPISPAQNADEDDDFTRAKTMEDALTARMNALSLPSAPSFHPSKKPIKVTKSIPFKDEEIETWCVICNDDATVRCRGCDGDLYCRKCWAEGHIGESAGYEEKMHKWVKYEKKKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R524</accession>
    <name>A0A6A6R524_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_273424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="37196" checksum="F6825114F55238B4" modified="2020-06-17" version="1">MITIEPGFVIRGRTEEGHDVHLWSFMYQQRGPEIIVDGDVSQSLFIATKYSDEEKLSMHDSPYVNKGQNIEDYAKPGTIKIAEGGPETTWTHTDRKYICTPPNWRVEGEHAGVHADINYKEISKGFFHLGAFENLKKEGGVAGYVMHGTAEGTITVKGKAYKFKGYGVHERIIQSGVVPDRTHYMGGRGLNWMHGWSEDFSWYCFKGDVGEKNFTGVINIKGESFPVQGANGGIEETLYWLDPKSKLQIPYRWKVWMETEKGRLESTVYGYARGYYTWIRKHGTMVVNQYQADAESKFTLKDGTVIESKQMNMIEHMRTMYRQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5C8</accession>
    <name>A0A6A6R5C8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">BU16DRAFT_480549</name>
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    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
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            <end position="48"/>
        </location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2499676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="272" mass="31083" checksum="86A5D8570A2010A6" modified="2020-06-17" version="1">MSYLVYEFLARTPELIVQRRIRLDQYANIAQISQLIVHLIILFCNFAASIPVSKLAGKSQKGSVAVLARIARSLYFKLGVNVGRGYGTYGQWIFGLAWTSWLGFLCIAETAPDYLHLTKRFGLIAASQLPMHYLLAMPHPYSPLQLLSKRSYALNMSVHKVTGKIIIAFFAIHISLYSIFFVQIDMFWTSIRHSNIVVALISAAILFTLGVTSTGLFRRRDYWWFYKIHLIGSVLILPLLFFHVNHIRIYLFESAIVLVMNAVLRMFSSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R5Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_604012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="136" mass="14825" checksum="CD1569E7D40C9A63" modified="2020-06-17" version="1">MSKMAPRLHYVCHAPATREKWVLAVQRKRLRGSFEAVARARRAASVARESCQSHGPRRICRLQFVLCRTLERSLQLPPSALPQCGRGSVSFLALQTAFLSVGPSRGCRDQTHRASRGCSAEVNRPAGAVVNGAGCN</sequence>
</entry>
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    <name>A0A6A6R6K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative DNA repair protein Rad18</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
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    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="735"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="942"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2500398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130939" checksum="5F90AC66CCE40477" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6Z0</accession>
    <name>A0A6A6R6Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BU16DRAFT_523984</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6Z0"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="46"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="168"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="584"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1121"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="926"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2499503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131503" checksum="059391E20949B873" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R707</accession>
    <name>A0A6A6R707_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_523063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R707"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="167" mass="19470" checksum="94D52439C1AC2245" modified="2020-06-17" version="1">MALPRRDLCRNQEKICVYLRTLRCPGLATEISQNNSTLRRRTRSTSFEIKDIELGDHSMGLGALFMAGTLPQNLQVLDWMAVSGVDQTIDGKGWLYFVGRTYDWENQHEWKRLVFIGRFRIPDNPSEATVKALLRRKRSKLPVDLLEQFLAGRDLPLAYYKVRHLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R758</accession>
    <name>A0A6A6R758_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_276028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R758"/>
    <dbReference type="OrthoDB" id="5230947at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="70" mass="7353" checksum="4B0BF2451C2E3F26" modified="2020-06-17" version="1">MGAVVSCIESIFRTIGNVLMTIVHAIGAVIMAIVNGIVALFDIIISCLTCGKAGGRRNRMKTGGHHTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7L7</accession>
    <name>A0A6A6R7L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7L7"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
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    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="356" mass="38057" checksum="01485763B2B85941" modified="2020-06-17" version="1">MATTLPPTSKSLTFLAPASPPHVISTPLAPPAASELVVKVHAAAINPVDIQLYNSGLLGWLAGKKEKGIGRDYSGTVVAVGASVKGWKEGDEVFGLITRPTGEGTISEYVHPVVGKDPLAKKPTCWTHELAAAVPLVVLTAFSCLDWLPADKKKNGFGRVVVAGASGGVGMWCVQLAKKLYNCHVTGICSAKNADFVREMGADEVVDYTSEFVGQALLEGLPAGRQYDLYIDCVGGTEIFEDLYTLLHPNAAYVTIVGDKTRRTAMGGPLTYLTNPAQVLRFIKGLIWGPRYANILLYAKSELLEQVAGLAERGEAEVVVQEVVKGVLEDGSDAWKKIYDFMEGGRVRGKIVAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7T4</accession>
    <name>A0A6A6R7T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_523428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7T4"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
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        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="244" mass="26675" checksum="B3EDD0E86E71E10D" modified="2020-06-17" version="1">MAFRPLLRQRAAVPAMAAAVSAGLILYPNSVAYAEEPLSDDTILSRKPIYDDTPLSHDPTPRPSEPSTPTDYRPTPTDRLAGQIKYARLAFYGQATKAEDAVNDALTKTLSLEHSFTSTIRGLAPPKGSNEKLLPGAIYVLVASMAGSIVTRNRNILLRGTVPVLVGLGVAKAVIPVTMGNVGELVWKYEKRFPAVADAHLKTRARVEKFIDTGKAHTQMSFYRVQDTVAEAREKMEDWVKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R896</accession>
    <name>A0A6A6R896_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_578708</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R896"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="511"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2500839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="775" mass="84943" checksum="BD67F74FD6EB03F9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8B4</accession>
    <name>A0A6A6R8B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_557988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8B4"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="24003" checksum="0C0989C73F32A450" modified="2020-06-17" version="1">MSSKPVALILGSGPRVGAAVAKQFANTGYSVAIASRQATEGKIAEGYLSVKADLSNPSSIPAVFDAVKAEFQSAPSVVVYNAAAFTPPAGDDLFSIPAESLASNLNTNTVSVYAAAQEAVKGWETLAKDAKKVFIYTGNKQNTGIGPILLTVTLGIGKSASAYLIGAADAQYSKLGYRFFYADERNADGSQKGMQLDGDAHADFFAQLASGEGEVPWHATFVKGQGYVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8W2</accession>
    <name>A0A6A6R8W2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_522173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8W2"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="708" mass="79087" checksum="311C2F7689B12A30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9A1</accession>
    <name>A0A6A6R9A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prenylcysteine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_522368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9A1"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025636464" evidence="9">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="10">
        <location>
            <begin position="152"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2501395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="563" mass="61756" checksum="7736A8A9433F03ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9F5</accession>
    <name>A0A6A6R9F5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">BU16DRAFT_570025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9F5"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="331" mass="36053" checksum="F045D19234DD6B99" modified="2020-06-17" version="1">MATPKSVFLLGAGYIGQHIIDLLLATNHPVAALVRNAEQAAAFKKAGVKTILGTLDDSELITEHSAQHEVTINTASCDHLPSVKAVLAGIRQRVLAGQPSIYIHTSGTLLLADEAKGAYKSDKIYRDDVPADIDALPPTAPHRHVDLVIVQAAREFGDRAQLAILIPPIVYGFNPVHKRLTIALPQLVRFALKHGFSGYVGEGRNVWSSTHVAALGRAYTTLLSYIETAAPSALLENPYFFTGGQEISFREAAEHVGRILYKLGRIPSPEPRPFVESDFGDVFGPVTPFILGANARNHAIRLPKLGWESKEKDIWSSLEEDEIPFILAVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAG4</accession>
    <name>A0A6A6RAG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_523506</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAG4"/>
    <dbReference type="OrthoDB" id="10679276at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="117" mass="12968" checksum="E9417625B672BF1D" modified="2020-06-17" version="1">MVELMMGQVEEERALADGRPERGMVEQMSMLSPPLESLAEEDEDEGQDGTSMVSPLLESLILETAEQNATEDEVVKGVMVVEREVEDVEEEGEVPNKIREDAKEEGSRLCNNALPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBM7</accession>
    <name>A0A6A6RBM7_9PEZI</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_532580</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
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    </dbReference>
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        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502195.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="557" mass="63574" checksum="482666CAFB6F8F6A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBT9</accession>
    <name>A0A6A6RBT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_555717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2501223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="152" mass="16448" checksum="28D9824CB24CCDEB" modified="2020-06-17" version="1">MASPTAGQAAGLRRLGRQQENEEEMHDAAGSRKDSYSVPCAPATPANGAARCDEEGGNGLDCLAGLVNTLVSVYTAQNRQWSITAKVTVCVTGSCTLIMGLLFVAYNDLVLSRVKRKHEREMQLNETDEHEDILHTINRKAHEPALDPSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC45</accession>
    <name>A0A6A6RC45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_426007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC45"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="229" mass="25966" checksum="0CF06FE0E98D8DA6" modified="2020-06-17" version="1" fragment="single">HDHIILTPPRPTDGPGMIEMHNDPAIYMNLYSPPFPFTQESFEDFYPIMSGTTQKAWEEYLEVVKWREERDRAVAERKEVEGSEKWVSAGLPVTCIRVAKEVVTGEEKMLGDFTIKRRRFAKIQDPEARAKRKAENDALPAGDPAIEWELGFYLSSTLHGQGVMPAVLRTMIQAFFIPFMNTHQISGGFFIHNNASRRVFEKNGFVFTGAVPNVFEIAESKAGAKGKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCG2</accession>
    <name>A0A6A6RCG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCG2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="487" mass="55026" checksum="689DE30C0F9A4A1F" modified="2020-06-17" version="1">MPTWPPLEDIQITLETLMRQSADFLLDLQRNGEDMRTFVQEATAGTPLSSDVAVIDQIFHGIDEAVLYRQLHTIAATIDSGDWYDLFARSTACNEEVVTELWYWTVEYINRLSDDLLLYQTTSIPNQSRLSLVVRAIANARVGAGLYPETLVHALQETKNVDHSTFAIKTTAERLLCLLRIHYTLSDRLGQLPDNQPLSLLSPAARPPPDFLEANLKELPSANEQLWHQIQVWRRNEDVYAAVPTAVHPAIYPTAASVTDLHERKKAIRDTKTAFAELPFANYDDQTENDDDEDDIVEPNGVLYKVRRGKHLEDLHSILKFGDGSGCNPNLRWEAIVAAFEAAGWEISSVKGDDPAWFRLYVGQAENVYARITYHQRHYQTGKSLHSRHWKQEGVSSTFVLLGRMPAEILEKCSKKEIGLALNVVEHLLAVKFQAISEIKSGKYIACKSPCDKCVNTAPGRSANARKSTYHIPVDEEISWIKQEYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCS1</accession>
    <name>A0A6A6RCS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_545742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCS1"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="398"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="567"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="672"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2502351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="730" mass="80300" checksum="2E63F9F149FE6C22" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCV4</accession>
    <name>A0A6A6RCV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_17115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCV4"/>
    <dbReference type="OrthoDB" id="2151982at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20810" checksum="E3E690FA7034AB0E" modified="2020-06-17" version="1">MAATLTGNTGQTTLPPLDNNNLIHHPDSCLGLSLPLIERIARILPHNPRTIVSIGSGTGLFEALLLQYEPELILYGVEVKSDPPVNKYIPERYAETVGGTWDLCSLAENAAAWLFVYPRDPKLVAQYLERYADSRSLEIVIWLGPREDWTVFEPCFKRTSMRAEMSQDGPLRPYEMMVIYRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD92</accession>
    <name>A0A6A6RD92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_8662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD92"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="99" mass="12088" checksum="9BB5C7A4A7BD3C35" modified="2020-06-17" version="1">MILALFHYSNSPQSSPCQMLSLTDRPANYASFPTLNHPGNYRTHHRQHPKHRSLYIRGRPSRRWGCSRRRPARRNRCRSHRRSRRLRRCRRRLRRRTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDE9</accession>
    <name>A0A6A6RDE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BU16DRAFT_474665</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDE9"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FADPNR"/>
    </dbReference>
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        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="934"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2502426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123024" checksum="CC63B4A75329B98A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REU8</accession>
    <name>A0A6A6REU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_22929</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2502902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="13517" checksum="942722AF4044D546" modified="2020-06-17" version="1">MRPGCPATLQAPRFPALLPFPSALEWASFRLPSSIRNPDAWLHCHRNIFCQLPLLCAIYSFWTITAQRARSEAPLSPLILQRFGFLSSGRHFKGHSRTLNGSNYGAAEWCHGPQRAASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFC8</accession>
    <name>A0A6A6RFC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_611870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="46853" checksum="64F33439612524C2" modified="2020-06-17" version="1">MKKTLLLCFIHGFKGGDDTFGNFPSHLKAILQHALPKVEVLAITYPKFETRGDLKECVARFKEWLQNKVIDLEVASSTPSPTVDPSVHTILIGHSMGGIVAAETLLSITREQPIHSPSASMSNTTSSTNPSDSTHSLPDASTLMFPYITALLAFDTPYLGISPGVVAHGAEGHWNTAKTAASWYTSLSSAFTSAAPETSAVEASKMLPAAAATSDATVDVAAAPLWQRYGRVALFAGAAGAVAAGGAAAYMKRDDLSSGWQWVGSHLEFVGALARGAELEARLAAVVKLNESQRIGFANIYTALGRAVETSAASNAGGYSYAKQISGPSRTFCNLPKKDLETGKFFVKSVNDKARDEAGAHMGMFEPRNNPGYYGMSERAKELVCGWVLGGSWYEEATGWGRGVALEEEGVVVDLEQEDGDEGVGTEEGGEGFVDLKGSVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFI7</accession>
    <name>A0A6A6RFI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_449758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFI7"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="24046" checksum="4E1F85D821CC58D7" modified="2020-06-17" version="1">MPETAPKVLSRLLQDDAESQSPKLQTVYDRQGFSKQILEFVEALRKVVNGDKRRVKRQEASPEPHGERPDMSRGVLDDIAVRQPSSLGYQPCTAVESTQLAKMPGNSACCPSPRIDHNSHDTRVFGDDMIHSDYFGISTNDSGQALPHPTDLSVPQACSPWLDTQSTVNTASGDIDLGFYTQAFSALSASGSNPDFPPLAVSKFQASFPDDQNRYAGSNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q984</accession>
    <name>A0A6A6Q984_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_545518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q984"/>
    <dbReference type="OrthoDB" id="10528610at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="28668" checksum="AB3F4110BAFC691C" modified="2020-06-17" version="1">MDHSCSRKRTRPLGRRTLSVDRGIAELYGRKPEGSSELPTDKDSDVESDVVQREIPRRNSAPSLPTATWKVLDGNSTYNPAALRDSWVSPHNSNTTRRFETQVPSTLEACLKTNLPIPTATQDSGVYTTSYPFIRGALLTNGFDIRTQKHEVTFYEPYYGPPEHAIRADAMDVSSDRTVPSPVKMSPQTYNPNWRQREEYAEKRKRQKEQRAEAQRKQWERKKERAIRVATRWGSAEQWRWCTKPTVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q986</accession>
    <name>A0A6A6Q986_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_429771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q986"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="97" mass="11068" checksum="3FC66C2249B9C605" modified="2020-06-17" version="1" fragment="single">DSSDQYVALSYVWGQTRTLRTKKDNLAELQEPGAVSDHDPSIAMTIRDAIKFTRDLGFQFLWVDCLSIVQDDANEKHRQIREMDIVYSQAHLTIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9S8</accession>
    <name>A0A6A6Q9S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9S8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="27683" checksum="9E8A344B706A98BD" modified="2020-06-17" version="1">MSQPKPTLVFVPGSWHGPSVYSKVLALLAPHAFKTVVIDLPTTQSDRSKNLTDDIVAARTAIEAETTAGRDVVVIVWSYGSVVGSSAIQNLTRPKGEAGKGKTGGHVIGMVYIATGFNQTGSSFLGAFGGKPPPIWNFNEETGFVDLTAVPPRELFYHDIPDEEAKALIAELRPQTIVSLTEASPLAYSGWMDVPIYYLGTIEDKGLPVEAQRVFVQMARDAGAEVTAEEAQSSHTVMMSQPETTAEFIVKAVKAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAC6</accession>
    <name>A0A6A6QAC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_471928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAC6"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2489154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="402" mass="46058" checksum="43E8B32428066476" modified="2020-06-17" version="1">MVTKRGKAAEQSKPFKQIIEEANILQEIKDSLNLSVAARAKQSPDWASEETRKKILPDWNSIKEDEDDFGEPLVDTSIANLIINKEYLVPESAGGIKLHESTRKSLTKVQDFHPDGIYSFELLRRHLQSITTLQEQYRWMLKEHGELRRNTATLDDAGGESSESHQSSDSLTASLKQLLERILIACHTMEVWSPENAKGQYEFAQDEATQDVVKNSKYKSVEDAIFQAWATLEESFENNVETAFAGYANVQLVYSPSPAVKADGVLDLGSLVQIMWKHPVRTLDGKELKDVPDLLLTDVQIAKDWSGKAERIARYAPHKLRDDNPTFLFVRLFFTTVEIEQICSAQGVQLENKWLDHCERMLLASLPYGDEDRRLRALRVPLTNCMSTWRSFWYPRRTERPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QAX0_9PEZI</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="147" mass="15564" checksum="45AD2EE3803C4ADD" modified="2020-06-17" version="1">MSTTSSGRARHLVGLVMRNMQHPRAPSSPRLHRALASVKVCAIPCITTSSTFFIHPRRNSAALLPDPKPQGPASSLLARPIPADHRPGAPAQKKQLCEPPVDARKARGSPLSPSAFSLTSQPPCNLHLPLSPIIGTANCVPARGEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Elongator complex protein 6</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
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                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
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        <source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCX0"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="302" mass="34398" checksum="965FDBD6E284CB7E" modified="2020-06-17" version="1">MADMLGGGGGVMGQFPLEQWFFEMPVCTRWWMTAALGASVLVQCHIITPFQLFYSWKTVFYRSQYWRLITTFFYFGPLSLDLLYHIFFLQRYSRLLEESSGRSPAHFSWLLTFASALLLCIAPMFSMAFLGTALSSTLIYIWSRKNPDTMLSFLGLLVFRAPYLPWVLLLFSVIVHGTVPKDEMCGIVVGHSKFWIVRLKMAWGLTKAVWYFMNDVYPPLHDGHSPLDPPAFWIRLFDGRPEPPPQIEEDQDTAPEPIDRDLPAVQVGESKAFFKKASQAPAALYSPGARPASEWNVGTEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD72</accession>
    <name>A0A6A6QD72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_566722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD72"/>
    <dbReference type="OrthoDB" id="3677589at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2489613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="280" mass="31062" checksum="B9CC1CA78FE1EA69" modified="2020-06-17" version="1">MVFESTAPEELAKLMKQFGLTPADIDLEFEGVRLTLDGAWTDPYEAGHLLFTAELLAYIIIYRFSRGMNVFNVEAEARNFLDVRLNDGTISEEACFNLSPEDMCLTIGVLTGDAGDGDPLLEGWKREDGYRAVERIVLAALKIAAVETLPFTEGEGIGTMEVWDDNDVVEFERGHRDGDGPPEDLSPVTLEAVGEKIDISGFTRAISCPLPPHMSCVICQLSLAGAEEGEERPIRTVCDHYFHFNCLSHWLNSAQDNSNLCPTCRTDLGCERRQRRPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDC3</accession>
    <name>A0A6A6QDC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_544359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDC3"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF10">
        <property type="entry name" value="TIP ELONGATION ABERRANT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46145" checksum="DD5058B41AAED047" modified="2020-06-17" version="1">MEVAAGAVAFEAATTTLEGGAIAGYAIAQKTMPLKATFTQIATSPQTSDRSSLCRLGHTVSVVDGKAYIFGGTTTEAICTNEMHILTLPSKSSETGTQYKCVPALSVEHQKEVPPPRCYHSATVHGEDILVYGGKDDDGLSLQEESKLWKFNTKTLQWSCLQYAEDEAGSGHAIYGHGATIQDDQLVIYGGVRSTPSEKQFRSPNLITLGLKVFTKRVAKHAMEPATCFPANLVAIDDAVYTINGDDELSTNVRQINLEAAMASRPATLEGDRGIKEIAIPSNPLAPGPKGPRDGAALIPVSTGHGRHYLIYMFGTTPSQAIVNANSSTPGKTSQASSFCSDAWTLQIPSSDLSLSGAKDKARDVLGMDSGSWSWSEVEIKTDTGESEHEGKLHPGPRAFAGYAAIDDRSILVWGGQDAAHNAVGDGWIIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDR6</accession>
    <name>A0A6A6QDR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_530781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QE31_9PEZI</name>
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                <person name="Bloem J."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="694" mass="78712" checksum="0D8393826E1DBBAF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QEU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">BU16DRAFT_531041</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
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        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
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    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
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            <end position="145"/>
        </location>
    </feature>
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            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
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    </feature>
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        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        <location>
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        <ligand>
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        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2490556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="329" mass="34309" checksum="A81A69F99ABDD239" modified="2020-06-17" version="1">MKVAVLGASGGIGQPLSLLCKASPLIDELSLYDVVNTPGVATDLSHISTPAIVKGYLPAGDGMKDAFTGVDVFIIPAGIPRKPGMTRDDLFKINAGIVRDLVKGVAEYAPKAYVLVISNPVNSTVPIAAEVLKGAGVFDPKKLFGVTTLDIVRAETFVASLSGEKDPSKATIPVIGGHSGETIVPLFSQASPKVDIPADKLDALVNRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAEKIIKAAKGEKGIVEPTFIYLPGVPGGEAIQKETGLEWFSVPVELGTSGAEKAINVVSGANDYEKKLLQACYTGLKGNIEKGVEFIKNPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFM6</accession>
    <name>A0A6A6QFM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_585190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFM6"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="35127" checksum="A41CC4E3FF042047" modified="2020-06-17" version="1">MVKVAIAGGTGNVASEIIEAIQATKKHEITILTRKENPTSLPGLRYVTADYTSRPSLLSTLRGQDVVLSFLVVHQDEDSIVQKNLIHACIEAGVKRFAPSEWGVSNGSGIPPYAHKDEIAAYLAEINKEKKVLEYCLFQPSLFMDYFAHPHALATHLYTWPFFVDYQHRRAMRLDAGTQPIVLTAIRDVAAVVALALDYPGEWPTVGGIRGSQTSINELIKLGEEIRGGKFAVEEVSGEDVENGVLKTSWVPWMDHPVVPVAERSEAYSRAFTVMFLVGIKRGAWDVGGQWNERLPEYRFKGAEEYLREAWKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG12</accession>
    <name>A0A6A6QG12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_517714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG12"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="107" mass="12444" checksum="DA60E2EC5257738D" modified="2020-06-17" version="1">MAVPRSRIVDLLRVQCRIFNTTFNPDRLRLGTKILSQRLRGPAVASYYPPRIGTTQDLRKLYPEYDVVDEEEDDWIEKLKVAKLKGKNPPKKKRTAGESKKFGKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG88</accession>
    <name>A0A6A6QG88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_553014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG88"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2490643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="53571" checksum="19299E7DD05B0D7A" modified="2020-06-17" version="1">MEYDTKTPPYHTSNKTSFAYFSARDRWPVIITQAIDDVYRATTAATDPDTVTEGKGLINALAKLKHELQHDRLLTPLPDDGYSDIVSYNKELAALENPTWFNVPWLFSECYLYRRMSTLFALSRKWKSYDIFARQKLSTFKSSRPAVVELATHYRDIVAKLGTGNNLAGEELEAAEKVLFMEMCEICLWGNATDLSLLTNLSYEDIQKLQGSSARKDAQANIVANDLNAAFAILRDAQKKDKNAERRVDIVLDNAGFELYVDLILAGYLLSSGLATTVILHPKSIPWFVSDVLPKDFQDIIQAVQDPQRLYAPTADDDDNYRNTYKPLPAKEKEDIEFLFQNWTSHVAEGRLLIRPNRFWTEGGSFWRLPTSDPSLFEDLKESELVIFKGDLNYRKLTGDAAWDPTTPFPTAIGPLGPGSGMRTLALRTCKADVVVGLPEGEDERLRNMEGGGGDSGARKWAWSGKWAVVQLCDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGY5</accession>
    <name>A0A6A6QGY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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</entry>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="31052" checksum="AD2621E1EF0051D0" modified="2020-06-17" version="1">MTGPPPLPYNLREHKKSIAIHWSITVSVACVLQIVLFYGLWFGTSIDRHTVFTITQVILGIFAIQGWAVRLWRLLKKNTAATPIGSSRRYLDFFQLSFIGGFVVSTLELVIGSLPERPNVRLMAMPGSSLLFYVGAQLLLVTLLHMGTYSSPVRLSSTARGSVCRPAVYYLIEDVVAVDGGGGVDYREALNVRYEASPMFRRLLLRLSFFWSIGALAMATIVTILVYAINEGVAYGIGWGIPFVWAAVWAIITTKWAQMALAEEERWFRQSAPGRNDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI05</accession>
    <name>A0A6A6QI05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_101966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI05"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="345" mass="36462" checksum="A64FDB888E34767E" modified="2020-06-17" version="1">MSLPTTYRAAVLETFGSPFVMKDLPLKLPSPGEILVKVIATGVCAGDHAVQHGQIPTPLPLVLGHETIGAIAAVPENEDHFTVGQRVGAPWHGGHCGFCRQCKHGVFQMCTTQIINGVSRDGGFAEYILLRREAVVHVPEALDPVKYCPVLCAGVTVFNGLRKMQIGPGSLVAVQGIGGLGHLAIQYAAKMGHQVVVLSRGPEKEAFARQLGASHYIDTEKSESGGVVELQALGGAALILTTAPSGSVIAPLLGGLMHGGKLLILGAAGEVTFNTLPMLFKGLSIHGWPSGHSIDSEEALKFCENHGVDCMVESYPLEKVNQAMEDMMAGKPRFRAVLKISDTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI39</accession>
    <name>A0A6A6QI39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI39"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="184" mass="20199" checksum="8DAE6F0D5696A57E" modified="2020-06-17" version="1">MFEDVKELQVAIAGLLVTACLLSHPGLCKAIIGFLAAVIDKTILAVQSVILILFTIIAFLATIGILQVTLIVVASIGFVVFVALAALAALSLILIFLCIIANFGSGHFPHQATHRLPEKSLPNDYYNSLVISESPRVEFMSLDSRKYKQSKLQKFHEKHMHLPLGTYAPVEVKKTRDQSDKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIR4</accession>
    <name>A0A6A6QIR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_564761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIR4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <end position="34"/>
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    </feature>
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        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2492305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="515" mass="57440" checksum="5E6F205B55C1C800" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJS5</accession>
    <name>A0A6A6QJS5_9PEZI</name>
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        <submittedName>
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        <name evidence="10" type="ORF">BU16DRAFT_114896</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 269.34</strain>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <dbReference type="EMBL" id="KAF2492482.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK31</accession>
    <name>A0A6A6QK31_9PEZI</name>
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        <submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <source>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="273" mass="29295" checksum="DF90FCA35F50A62F" modified="2020-06-17" version="1">MSDKQLVGKVALVTGASSGIGRACALSLAKQGASVVCCDLRAEANPQGFEPDLHITTPDVIIGLGGKAVFVAVDMGDLKQVEKAFKETIDKFGRLDILINCAGYWASPFRDFVDETDELWQKTFDVNTLGVAKACRLAISLYKKNDLDETWGSRGRIVNISSCAGHVAIKGEVAYSASKAALNHITRAGAIDHAKDHININCVAPGITATGISRVNFEDENIINTWKKINPWPRLGKAQDIADAVMFFCLPCSQWITGQLLPVDGGFTLGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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            <end position="319"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="327" mass="35990" checksum="BDF93F6DED8E9E7E" modified="2020-06-17" version="1">MPYKRAESVVSDPAILDAPHCPPIMSDGNRDRSIWRPADGNGDPNRELFMRSFLNKWGHPTWKLFIGDVADEIEPTKNEPPRHVYLDDKAAYTILNHKAYTARERYQYWAFDFNRQGMIRTNRPNRGRPVYQDEHQLSFASAPQLNRPIKYIFSGGLSTTQVPVRTNSTHSQNAAQSRSSHEPTSYDLSGSFKHPEGRPGLSETPFNSKPEMAPLVAASENGADRPSFCAASTANTGGLAIPKAAPKAHNPASNTALWASTDSEQVQDSAAGTRVLSKSLNRSTLKRSLSQAKMTQATPDTIKKRQKRSAGSGSGSSNSIYCSRDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM82</accession>
    <name>A0A6A6QM82_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_583270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2493100.1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="608"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
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            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
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            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493100.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="68782" checksum="5807DBCCE73C7229" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM99</accession>
    <name>A0A6A6QM99_9PEZI</name>
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        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BU16DRAFT_514107</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="893"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="27">
        <location>
            <begin position="125"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="26">
        <location>
            <begin position="273"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="97"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1139" mass="118973" checksum="C301A97D59CD3024" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMH7</accession>
    <name>A0A6A6QMH7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">BU16DRAFT_465092</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the isochorismatase family.</text>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QMS3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="32927" checksum="39BF0709E6C21A59" modified="2020-06-17" version="1" fragment="single">MEPTADEDKDRVRRFVLAGMRTACHPRVARMIASSHLRQVMELAHNAEQRSSAPLPGSSLLHNRTVRGGQGTSERSRRGSTFVGQRPFGAASTSSPRPTMGQLLEDDDSETEEGAEGRPAKRSRRRTRTSSPGRLSPQPDAPTLETPSGTTPPLKVAIPGRRIDQKVFDKLPRRLLVREGKERDISALDEKDKDWLNNAINLQFKADRTPPWLISEEKRGRCLGSLSLRRAPVVWTEGLERKRACVACKTRPCVVIEAEREQDGTEKEEGEYLLVLPGGDPELPWRNRGYWVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QN55_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">DUF1365-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_491912</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="684" mass="76979" checksum="9226A236E0FC7B65" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNT8</accession>
    <name>A0A6A6QNT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="4">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_488702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="4"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNT8"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2493902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="990" mass="109141" checksum="D2F27985B4CD2C03" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP77</accession>
    <name>A0A6A6QP77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_465403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP77"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="836"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493513.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1214" mass="137688" checksum="D1C91729C2C50CCD" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lutzoni F."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="130" mass="14686" checksum="825F66DFCFC105F9" modified="2020-06-17" version="1">MADIPDDSTFDDPCTAEDRYFNDPRTTKEIKSVTDPKTQKTYDVLVLKGGTKWQHEKVAAIAVEWHTHGLVNIPFNLDRNSREGTADYDILIAFDPRMGNYSQIGNMSREYAHAGIPSMNLCNISSKTNF</sequence>
</entry>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="417" mass="46995" checksum="0B5E2E87B28EBB33" modified="2020-06-17" version="1">MAAKHFRSRSTATIFDEILMPAIAGSYGQRLPLPPLLKYRSPFGPRLYNSLNQAVAYLTEERQHHSTGEQLPSSHVSVAISDGATSRMSRLNPNDLLQQPLHWTAQHGLHLQQDGRPPMPITITSLMREYSTNGQHVSFGPSSQDQRRPTFEPFEPGYQPAMSSQYNQIQYPQAGYGQPTMLSRQIPTFSRQPVGNEEYGQEEEPAQQQHEAVSGYDQHGQVVLYGPARPQAAVVPLRAPPLAAVVPLRAPPRAPNIQQFVFFWYEGTPLPRQKAGLTKAAFYTLQFLDKSVRTMMIRYVCPRPNLASKHKVTHPSGPIHQSRATPMSKLLVVNKHGETVEADHITVSYKNAELVARRKHITAHGYVEGPRSFEVIDATSDGWPHDDDARHRREHKDRWPRIMDSTTMDIDLSNPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QRJ0_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
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    <dbReference type="PANTHER" id="PTHR47804">
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    <dbReference type="PANTHER" id="PTHR47804:SF1">
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    <dbReference type="Pfam" id="PF13515">
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT07"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="383"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="904"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2495309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128547" checksum="B229EBDF845ABA1E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTX4</accession>
    <name>A0A6A6QTX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_526399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTX4"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="52"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="556" mass="62068" checksum="1360A30CCC70B795" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU85</accession>
    <name>A0A6A6QU85_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_549623</name>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5575144at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="33"/>
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        </location>
    </feature>
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        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2495955.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="658" mass="72119" checksum="0936807A70789938" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUC1</accession>
    <name>A0A6A6QUC1_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUD0</accession>
    <name>A0A6A6QUD0_9PEZI</name>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025712110" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="43"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2495796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="528" mass="56548" checksum="211EF3FECA9872E1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUG3</accession>
    <name>A0A6A6QUG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_365276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUG3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="154" mass="16782" checksum="5488D00CCD98FA17" modified="2020-06-17" version="1">MEFEMENSLRVRRSGLMADGGDEVRELTRRVQRGGVNGPGAIHDAVPNATIRQSRNGMRHGGVHASAERASVQTALGRAQPGWWCRARGLRGVTAARKEEQWRRRRWRLVACGGDDLGVVRCVWLRLTRSVEAAEVASARSAGGSLQAVESAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUP7</accession>
    <name>A0A6A6QUP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_510602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3914029at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="25294" checksum="7BE7BB97E14C1DD8" modified="2020-06-17" version="1">MSKDGALPCYEESTNAHLHSQYHTSNTSDGQHIRDRVRAIREEQIASVINEHVYPLISQQATYGIGSINIALMPSDVVLPQEDKVKSDTEYDFETSDGPQVEIIGFPEELQRIQLEGHVNRLEFWKQRGVVEELERALNETLDTSSQSTVTTGDVQPPLPQRPAKKGFFGRTSSSATTETSGPLPKEKNSLKLTARLEEICLRTVSAFGLYETITRQSIIIKFSAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUW0</accession>
    <name>A0A6A6QUW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_391565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUW0"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="233" mass="26676" checksum="288ADD45D33ECAF9" modified="2020-06-17" version="1">MASPSRNEDGSARTIREQLQFCKHQKWGFIIYRCTYSSNADWKLFIDRLNEKAQEGLEASGALDLAPTLDLTVFQDKSRYNGASKDDIRKDFKHWVKSDEAAAEQPPTGAGVANKNMFGQATRYTFPVYVDEEAMRSVIDPAPDKWPHSAYIILIDGDWELRDPETFDYEAMGFDLDEDCMDDGEEPIEGCRLEDVGWLKAMVLDLIPGKYAGLEQPGQWAFYYRRPPGMWTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV79</accession>
    <name>A0A6A6QV79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_582262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2495633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV79"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2495633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="634" mass="72142" checksum="1B21CB35697385E1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVW2</accession>
    <name>A0A6A6QVW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_526958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CSTF_C"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495067.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="301" mass="31981" checksum="F68D7D317A86E406" modified="2020-06-17" version="1">MPPAPNDKAGKVVFIGNIPYGGTEELIIDTLTRVGQVVNFRLVYDKDTGRPKGFGFAEFADADAAASAVRNLNDYDVMGRKLRVDWSNDNGAGDAAPAGYTPAPLPTNGQELVQPPQASSLPPLPPGTDLQPGLSAPDAISRTLSTLPPAQLLDILSQMKGLVMSDPAKATELLRQAPQLSYAIFQSLLLLNLVDTSVLTTIIDPNQAAAPTPAPPPQPPVQQLPHGFPGYPPAPVPTPPVYQPPMPAVAPPQGAAPSKEDLIRQVMSLSQQQIDVMEPATRQQIMMLRQTLMSGQRPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW09</accession>
    <name>A0A6A6QW09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BU16DRAFT_560743</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2495883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF4">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="548" mass="60000" checksum="46DF3F2334678A77" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWD4</accession>
    <name>A0A6A6QWD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_460545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42344" checksum="442DD4702E796CE6" modified="2020-06-17" version="1">METEIYRHPIPEPSDNEVYLLRVPKFFGIEPTAWHHKTFQPPTTDHHSKGPASQTFSAYNTALTTLRWRRSPSKPSELQSNARILRWSDGSLTLQFASDAVNQYDIEGNALAHPQYNPKKPTPTSQRTKPGRPVPHYDAAHDAFTYLAAANNEVLLVTNKFTASLGVNPVADTNDEAVEQLQNALAEAAKKRNPHTEMGGLNVMDIDIDPEAEILKAQAAAKEKAKQARSREKAQERERDRANRTLGARGLRTAGELSAKDLEGGGRAQGGAKKPRPKTGLRRDWSDDEDYGGRRHNREDEYDEEDDFIAASDEEDMGEASEEEEELDEPEERPRRKEADSPKRNRAAANDAGDEEEVAANVARTKRRRVIDDDDDDE</sequence>
</entry>
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    <name>A0A6A6QWK0_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="131"/>
        </location>
    </feature>
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            <begin position="176"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="211" mass="23581" checksum="29CDC4373F0ABC78" modified="2020-06-17" version="1" fragment="single">METYQGHVRTPTDAILLFEACRLGLLPRVQRRLSEKERQQIKSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGIHLPPLPQGTSAARRARERSNQQSDGSKGESDEDGPDGYRYKPDGLMKQSFSITTQNGQHLHLISYYARSHPTATDLRQPSADATLRHIRPPKNMYPESTVNESTGGVPAVTRGPMPGSPYAHSP</sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="18701" checksum="F491B7986268B269" modified="2020-06-17" version="1">MCYLNITIHNGCGHRAPSVSDPYTLCNEALVRLAEATGNIADSMPPPPPPRPKRTSTSISGRFTSLKALGRTSSTSSTISKRSVSDSVTSPISSSFAWKASPSSAIAARCETPEVRERVNSGMDVCEECRRWVEEMRFLVKRYDQSGSVKGCKAFDEFLRDRENGHRYY</sequence>
</entry>
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    <accession>A0A6A6QXW2</accession>
    <name>A0A6A6QXW2_9PEZI</name>
    <protein>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2497295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="257" mass="29250" checksum="36A1EF6C97B4CF55" modified="2020-06-17" version="1">MGRPNYRGPSRQQRNRKIHCGDMGLPRWSENRMKSISATQRVVAAVAQLHRFDFRWNDISSSLSSSSLYLDCGEYTRSCSSIPAQRHVVWRGGLGSFDPAFNVLLFLLQSFSRPLSRPFSEEFQFALAYQILATHPGTEEAPLTVECPLASRVLLLLSQRLKQHFEKGEEERESVLAEGYSHGAQLPCSAILHALGKTREDCEKQHRQILATSRKEPGREAPRNWGITEEASLKKMKDVQKMKWKNIGIAWAEVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY06</accession>
    <name>A0A6A6QY06_9PEZI</name>
    <protein>
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            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2496523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="296" mass="32350" checksum="D235BE6CDCAB71C0" modified="2020-06-17" version="1">MRVAWTRLIRFIATDGRLLRGEPILPDPDFDLGTTTEHSKLQAKVIIGEDPYDNSGVTRVSDEIVTVKKLLGPLAPNDLDILRCVGLNYAKHIKEAGRTPPPFPFIFFKPTTCIHDHGEDVIIPQIAQDDQADYEGELVLVIGQDAKDVPLEHAMDYIAAYTAGNDVSSRKLQRDPNLAGRVPQWGFSKGFDTFAPLGPALIASELIGDPKELLLQTIVDGEVRQKEYISDLLFDCAYLVHYLSQGTTLRKGSVIMTGTPGGVGAGLKPPKYLVPGTVMEISISKIGTLRNGVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY67</accession>
    <name>A0A6A6QY67_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2152680at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="573"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
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        </location>
    </feature>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="573" mass="62795" checksum="0903A4BD9DD23A79" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYN1</accession>
    <name>A0A6A6QYN1_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_580206</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="462" mass="51467" checksum="74F188CC084D0CA7" modified="2020-06-17" version="1">MGDGGTTVAFIIAGVLGAIVAWIGVHYCRRWIKKRHVDMEREDYLKETQAAQDAERGRDRKRKRRPREKRDERDVSEWQPPVRDVRMPEDYIPQPPLEELPPQPLQPLEPPQPTMPTMPEPVHVDYIAEVDELPEVIAGLQGRRVQERECRSCSTDSSSSSSSSEAARRSRTSDVEDVGPRDYMRNHRPNPRPNPRPPPRMPPRVSRGFNFNGMPPMAQDTGRGGQRGRGWRYGTTSPRGRIPVLNKPDRTKWRNAPMKSVPEETPTQTGEIDVRRPPSTATSEKVAELPAPPQTNSQETGQPAKPPPEASEVDDVPEAISERVENATFVADVRGPEPSPVPSEAAIEHPFEPVIPETVIEMPPMPDPRYLHSPPTPTSLISSFHTCHYASSLRGPSSDFSRVYRDGREGASSVGTNGDNFRHSLDPNEAYMHPDLPPNSSMEAVIGRPPSIMSSLDGYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZD0</accession>
    <name>A0A6A6QZD0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_559543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5423818at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2497815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40392" checksum="E47515F92EB9FFC1" modified="2020-06-17" version="1">MSVIALDPYLYGGIEDETFGSNLCIFKWPEPFSVTPDATPRIEELYHPGAGRQLSPLSLDLPLSIPDLLTPQNPRSLVRRSMGKPLAQTSADILLRMFGSFTSMMARKETFPPFINSKCFSNIPGKENEIPEALVNCMSLSRMFAERTAGTSKLLWRTIRMEHERLWFQHDSFNNWELLAAVQALMIYALMRIIDGETEHNDFDVPLMISVNSICQRLADRIGGGDYHNIISDQKAWHDWVFYESRRRFIIIARILNLLVDMGHSLTCSSLPGFILVPLPSKKVLWEAPNEEVWQKEFETTLRAREIFGVTTEGRLVRLVQEMNRITATNAEWEEWYAGSDGFGSLVMLAASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZY3</accession>
    <name>A0A6A6QZY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_537596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZY3"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="490" mass="52898" checksum="B1022F16015FBCC3" modified="2020-06-17" version="1">MAFRVSSRRLCVALTTPRAAVVCPISSRYASSASAAVAQSNLPRGLKDSIAKEASLPNSDPAESSQTARLVNDQLPFMVPTYVRPPPMFEKGEGCYLWDVENRKYLDFTAGIAVNALGHCDPEMAKLLGQQAQTLIHTSNLYHNPWTGTLSKSLVEKTVESGAMHTASKAFICNSGSEANEAAIKFARKVGKVVEPSGEKYELVSFHNSFHGRTMGSLSATPNPKYQKPFAPMVPGFKYGTYNDIDGINNLVTDRTCGVIIEPIQGEGGVNVATTEFLTALRKRCDEVGAVLIYDEIQCGLSRTGLLWAHGSLPAEAHPDILTTAKALGNGFPIGATIVNEAVATKIVTGDHGTTFGGNPLGSRVAHYILSRLSDPELQKGVLEKEQIFRKHFKALQKRFPSIITEVRGKGLILGLQLTQDPTPVVTAARERGLLVITCGTNTLRFVPPLVISEAEIEEGMKIIEDAMAAVFEEPGKIEGTKGQQEMQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0G2</accession>
    <name>A0A6A6R0G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0G2"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="29902" checksum="8463F571D5D51EE3" modified="2020-06-17" version="1">MSNYNDNDSYGSNQRGGDSSNYGQDSGRTGGLGGGDSYGQTQDSTRTGGLGGGDSYGQGNDSSRTGGLGGDSYGQTQDSTRTGGLGGGDSYGQGNTGGLGGDSYGQGNDSSRTGGLGGDSYGQGNDSSRTGGLGGDDTYGSTKRSDNDSYGNDTSSNQYGSGTTGGAGFGNKSSGNDSTFDSSDTKFGKSDETTPYSGSTDYGSGTTGGAGYGNKTGGRDDDDSNSNKKSDSTMGKLMEKAGGLLKNDGIAEKGRVKREEKGFGDNDNSYGGSNQDSSYGSTNQDSSYGDSGRGGNNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0R6</accession>
    <name>A0A6A6R0R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_456471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0R6"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="33241" checksum="A5F543776B4330F4" modified="2020-06-17" version="1">MTTPLPDQILYLIIRFTASIPDLPLSISSPRTLTTLSLKRLIRTHLPPAHASSRLRLIYAGKVLADTAPLSLSLRLPPPPPPRSTAYNDSSQSKGKGKEPVRDLPPDNSPRLYIHCSLGDALSPGDLAAEASSALTSETSLAKQLSKTTKHSASGSTSSATGGGRRDSAATTAAPQGFDRLLSTGFTSTEIASLRSQFLTNISFTHTPDNMPSGAALRALEDSWLDSSAHEAPAGDATAAAATATEGEAGWGAGFGVDDGGLDDMLFGYLTGFFWPLAAGVWGMREEGVWTRRRQVAVVMGVVLNCAFGFLRWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0S0</accession>
    <name>A0A6A6R0S0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_617050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0S0"/>
    <dbReference type="OrthoDB" id="5600418at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="652"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="809"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="875" mass="99982" checksum="C7EC3EF27FD744E0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1A7</accession>
    <name>A0A6A6R1A7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BU16DRAFT_570833</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14 21" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 20" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="26">
        <location>
            <begin position="886"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="27">
        <location>
            <begin position="1623"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="1915"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="21">
        <location>
            <begin position="1438"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1805"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1974"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1833"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1890"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1900"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1978"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="2023"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="979"/>
            <end position="986"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF2498319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="2081" mass="231313" checksum="A3CCB92B0ED74F96" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1P7</accession>
    <name>A0A6A6R1P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO/MBR-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_481675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="188" mass="20754" checksum="39E43B255561A396" modified="2020-06-17" version="1">MTSYVPSLTLPASIFEHPASSILLPVVLGTGIGFSTRPDKKHHEHLALKQPPFDPPPQVFGPVWTALYATMGYTAYRAWNAGITSLDLNKTILAKQGATLYTIQLGLNLLWMPLFFGLRRPIEATVDIVALTGVTGYLAYIWGQVDPVCGWLLAPYLGWLGFATYLSAGCGYLNNWDFKGMYKQPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3B2</accession>
    <name>A0A6A6R3B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_614593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="420" mass="48522" checksum="EF090BE8D2175747" modified="2020-06-17" version="1">MSLGGGCIPLVPPKRSKKIAVLSLAYDIALYNRNFAQLSYRIRKSNLRRARPSLRKISKRLNGEHGPLHRIPKHTPTNLKTIKKLGKHDSPPVQLPSPDASKEEVRLFIHMVLTHEVHQIYKHYPEFIVATVYAWLGNGQDFRNLEKDDFFALCPDMISVPAFAGQMKKRKLFWGKTKVKPFRVQATFKCTEAIGEALWNSFRRLLAAEKKQKNLEDRQRKQDGLQDTADSNQDAPTHRQFEPDSVSHAKATTKRKARVQRVSKCTAFIEKPQNKIDEQAMIAESIRKERFEHLKRAQVVGEQSITRKTRVQRRRYEVKYHSRNYVPEVPTSGSERKVTYAPPRNFAESAIVDAFEECRKFYKDETIVPNPLPPKGSFGRLFNIETSEEGRDITVTYGNNVGLSTFRMWKNVDRDSQSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R3P1_9PEZI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4932428at2759"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2499388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="163" mass="18853" checksum="6E90ADDB77F7A859" modified="2020-06-17" version="1">MANSNQQAEKDQLISALRARRINTLLELRRIEKAFALLGSPDVTEPMTSAWSYYVNSHNLLTELRALTKNYPFSAEVLEEAKRRVYSDPNSNRSWNFCWLVLSKVQTDGLIPYYAQYQASQPTMWGNRQPTSESVAQLTNAFVAEWNWALGHMLRNWEQPPSR</sequence>
</entry>
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    <name>A0A6A6R4P6_9PEZI</name>
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        </submittedName>
    </protein>
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    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
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    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24320">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00106">
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="337" mass="36914" checksum="4C5DA1A128EC5AC3" modified="2020-06-17" version="1">MFENLPTYLNVLTYQCLWIPEPPMSEKNVPDLGGKVLLVTGGDTGIGYHLCRILYSKHGSVYLASHNVKRGEAAIKRIKAAYPASLGRIHGLYLDLEDLASIKASVKAFTDRESRLDVLWNNADVMTPLVGSKTKQGHEMQLGTNCLGPYLLTELLKPLLQKTAAIAPLYTVRVLWAGAASIVFFAPTGGVQMDAGTGNGKDAKPVPQWSQIQNYAQSKAGNLFLADGFAKEVVGSGIVSVCFNPGSCFTESGWHMSGSELLQRLILYPAEKGAYAELYCGLSPELTAWHNGKYFAPWGCLSRTRKDIDEEAPVTNVERNAPDEFVEYCRRETAAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R576</accession>
    <name>A0A6A6R576_9PEZI</name>
    <protein>
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        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R576"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="199" mass="21776" checksum="A992221CD0B0B2EB" modified="2020-06-17" version="1">MLGILETRSKKRKGILCLSGMSLSPFEDRYACHQYRLREVSARGSFRCICRCVTAYVAVACQTGCTRRILSCCFLLSNTPLVANERRFVNALGINSTIAAPWGSGWIWQITAPTKARSVPRLGTSGRRTTCPWEMALKMRSFQVAGSAKNFGAMAGPLNAPSGKAPAVNRTLTMVPGRTDVDTDSRVQSLQIVPPNVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R589</accession>
    <name>A0A6A6R589_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3799856at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="498" mass="54397" checksum="BCB1C705566F115F" modified="2020-06-17" version="1">MTPATGKRRARSLSPTEAGPSRNVRARQQSSHELTPGRHVDLPTRTSTAQRSRSVFRGDADPYFPPNAINSITTSSAEMSFYVKYLCRGFPDDELYKEAVQGLINITLPPDVLNQLSLDTIIAQMVAHGASEERMQRAREVIERELIDKSAWLLAKQLDTPEKAEVGLAAVTAATHRLYTQPNESDYHAFDRIAKAFASLRDGVADQSNNIATGSGLFAPALDESSDLRRIRRDTTLEPSPIHTAINGQAKNNAAQVKEEAMTDAGGLTPRPAPAALEISDSSDDDQSDADSSSSDSENGNHHGSGSDKASDSERYHPVKVEEFGNKDLAGKPPTVWNLATVVFPEDRKEDIRKGIINYFHAHKSNCPGFKVKKICQKQGQGAFYGAVTVRFEEPVRWHGKQIQLGNSEHLMITGGTQECSGCGAAGHSIWDCTTASAAYCAQGIGKSKKPWIKQVAQKYVPSADIKKGDEKGKKVKEDSKLQSKKDKKKKGKAKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5H2</accession>
    <name>A0A6A6R5H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-acetylhomoserine ami</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_277252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5H2"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="52406" checksum="07B5EA8AAA649771" modified="2020-06-17" version="1">MVSGHLGQVTKTPEFETLALHGAQEPDPINGSRALPLYQTAAYNFTDAADGASKFAWSKDGYVYTRMGNPTNSVFENRMAMLEGGVGAVATASGHAAQFMAITSACEPGQNFISTMNLYGGTFNQFRVYMKKFHITCKFVEGQDPNNIKKAIDENTRAVYVETIGNPQFNVPDLEAIANVAHEAGIPLIVDNTFGMGGYLCKPISLGADIVTHSCTKWIGGHGTSMGGIVIDGGHFDWSASGKFPGFTEPADGYHGMRFWETYGLKALSAKLRMDAMRDLGPCMSPFNAWLFLQGLETLALRGQRHVENTLAFAKWLQAHPCVAWVNYPGLESHTDYARAKKVLPKGAGGVLTFGVAGNISEVAAVVDNLKLCSHLANVGDAKTLIIHPWRTTHQQIPDQEKIRGGVTPDMIRVSLGLEHIEDIKHDFEQAFVGAGLKPAQGWIPTWKKDMESKDWNEGTLYAPAPGAPEGVKEMAARAISASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R630</accession>
    <name>A0A6A6R630_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R630"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="27764" checksum="12AC7DB02E35669D" modified="2020-06-17" version="1">MKLMITSNDVAHMEAKAYYRAMGYIRIGSDSRNNLLISLPSSTIRQREPKFLPTNSNSTAPAAPYFYEGNSCNRHHRTSISNAYPMSPPTAPAPIPFKVLEVDNLCVPHYMVERYDDRCMIYEIHFKCNCVQVNHVWRCKKWTAWARGSNEEHECGDDLEDFETLNLDMEETSRGIQKHGCAGKDKGKLCGCTDKLNPGVPLEERGCKKLTRELKEYQWAQTETVRRAKAAGVVKTYFNMPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R713</accession>
    <name>A0A6A6R713_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7626 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_556848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R713"/>
    <dbReference type="OrthoDB" id="5321209at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056043">
        <property type="entry name" value="DUF7626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24625">
        <property type="entry name" value="DUF7626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7626" evidence="2">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="574" mass="63786" checksum="4655EA824AE1132B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7N3</accession>
    <name>A0A6A6R7N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_614157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Goodwin S."/>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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        <property type="entry name" value="F-box"/>
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    </dbReference>
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        <property type="entry name" value="F-box domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="214" mass="24410" checksum="6EA62A770C58C2DF" modified="2020-06-17" version="1">MEKMEASAAKRVLGVTELLEFILLELPIQNIFQAQRVCKQWKEVIANSSPLQQAMWLIPRDPSSPPAIYEDEEVTITTWRGRVYDPPQVHRLITAKHLNPFLEPHSSDTEDSPGWMRYQVFHPRARDISTVRLIANRRLDFTMPNIGVAASGADADHRATWEDMQVASPPCTRIEVCYGPVMAFDVRDETGVRLGRLVTELAMLQSHSEAWYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBP5</accession>
    <name>A0A6A6RBP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_554278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBP5"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="751" mass="82955" checksum="0F34FC6E190FFBBD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCH4</accession>
    <name>A0A6A6RCH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_522407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCH4"/>
    <dbReference type="OrthoDB" id="3742224at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="62"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="804" mass="90831" checksum="1B5C41D03465C9D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCN9</accession>
    <name>A0A6A6RCN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_546706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2501503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2501503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="202" mass="22414" checksum="308B867E4EF03EFF" modified="2020-06-17" version="1">MKITYIGELCAETSLKTSVNVFMRGTVAELMAVSAGIIVKGAKAKDPNGTVQREVVQDSKTGYNVYVHHNYSKVQGGFVALLMADEEYPARVAHQLLNKVAEEFIVKNPKKTWENATTPTTLPFPELATYIETWQDPNKADALTKIQKELDETKIVLHKTIESVLERGEKIDDLVAKSDTLSASSKLFYSQAKKQNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCZ6</accession>
    <name>A0A6A6RCZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_522546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCZ6"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2501610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="444" mass="48372" checksum="AB56603F89E8F3F4" modified="2020-06-17" version="1">MQGFAPAFVGGFSDSTGRRPAYFICAIIYAAANIGLGLQNNYAALMVLRCLQSAGGSGSVALANAVVSDLVTSQERGVYVSYLSVAPQAGPSLGPIIGGLLGQYLGWHSVFWFLLICTGVVFVPCAIFFAETCRAVVEDGSVPPPKWRRCYLNTKLERRLMAEGQPVLYEKRDELERKRKLRFPNPLETVKIVFTKEAGFVLAYVGILCCAYYATVALIPSQFGTVYGFNQIQIALCYLPLGCGSLLASFVRGRIIDARYKAHAKRLGFPLEYNRQVDLSDFPIERARLEAIMPNLALGCACFIGFGWMIEYKVNLAGPLIFLFVIGFCVSASINTVSVLLIDIYPGKAATASAACNLARCWLGAGATSGVAPLIGKIGIGWTTTFFGLLAVVFSPILWYVMQNGPKWRRATKLRKERQKAERAAKAATGNENDQQLKDRVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDI9</accession>
    <name>A0A6A6RDI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caib/baif family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_556282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDI9"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="451" mass="48785" checksum="B6FE9BA022A51E01" modified="2020-06-17" version="1">MLLNTLSRSSRTQLRAQWSLAPFTRQRNAPWRGIAAVAEAPDTSTLPLAGIKVLDMTRVLAGPYCTQILGDLGADIIKIEHPTRGDDTRAWGPPYAKHIKGEHMDGPGESAYFLAVNRNKKSLGLSFAHPSGVEILHKLARECDVLVENYIPGALKKYGMDFESLSKINPALIYASITGYGQTGPYSSRAGYDVMVEAEMGLMHITGERDGPPVKVGVAVTDLTTGLYTSNSIMAALLGRAKTGKGQHIDVALSDCQVATLANIASSALISGKKDSGRWGTAHPSIVPYKAFKTADGDILIGGGNDRLYGVLCTKIGKPEWTTDDRFITNAVRVKNRVVLEGLIEEETKKRTTQEWLEVLEGSGMPYAAINDIQATLKHEHVLARDMVKVVDHPTCGPMKLVNTPVKYSFSQPSIRSAPPTLGQHTDEVLRDLVGLSESDIEGLRSEGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDK9</accession>
    <name>A0A6A6RDK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_24257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDK9"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="309" mass="30851" checksum="47CCF2603767DF03" modified="2020-06-17" version="1">MLWEATVDSLNVQCSQDYAYWIKKSLISANSGTTFSDKCPTTTSTAAPTPTGGVSPNGLCGPSNYGYTCQGSGFGNCCSEYGYCGSTSDYCGTGCLPAFGTCGSVSTTKTSTTSSTKASTSSFKTSTLSTKTSTLSSKTSTLSTKASSSSTKASSSSTKASSSSTKASSSSTKASSSSVKTLSSSTKASSTSTKASSTSTKAFSTSTKASSTSTKASSTSTKASSTSTKLSTSTKLSTSTKLSTSTKALTSSTKASSSSTKPLSSSTKVSSSTKISTTLTTLKSSSTSKPASTSSAKTSSSRVKTSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGR3</accession>
    <name>A0A6A6RGR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_532976</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGR3"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="68"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="299"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2502637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="748" mass="85069" checksum="BABE1FBF87467D8A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIE6</accession>
    <name>A0A6A6RIE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_34174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="95" mass="11211" checksum="15ED77C469E08BC5" modified="2020-06-17" version="1">MRSSRWSMQAQPHRPPTRSAPHVFRQRHCIMMLFVRNSFPRPTITAIEIIYRSLVCISHLTVLCRSIDSRDRLATSLLYLMSMHVYFIHVKAVSR</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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    </evidence>
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        <source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="146" mass="16119" checksum="41EA0859AB7D8307" modified="2020-06-17" version="1">MAKVLSIIIRAQPPNPAIPARLVPKPQHRVNLPPSVAATATARLSHGPFRPSAAFASWPELVGLFGQWWKKREIPHDVEPDDWGVQDGSPPSYNRRKTAGPTRGLSLTEFDSAIEEMEDQMEELSAYRCYSEHAVGLGAGRLTIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9H6</accession>
    <name>A0A6A6Q9H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_224036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9H6"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="19350" checksum="FDD1B5E40AFA990D" modified="2020-06-17" version="1">MAATTLEAPQKILLQTSDNVELKVDRDVAERSILIKNLLEDLGGEGSEAIPIPNVNEAVMKKVLEWCEQHRKDAPATQDDDSDSRKKSTDIDEWDQKFMQVDQEMLFEIILAANYLDIKALLDVGCKTVANMIKGKSPDEIRKTFNIQNDFTPEEEDQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAZ0</accession>
    <name>A0A6A6QAZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamylcyclotransferase AIG2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_161585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAZ0"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22456" checksum="833FB4C751A6E6D4" modified="2020-06-17" version="1">MACRISTPNNSPQQQSERSASTVGRFPTQAQTTGDQYNSLPDLLQQAMANQFSAYDLRGFVALAEPPMFLFGSIMFPWVLNMVLELDDPRQMAQLMTPGNIRGYEAYEIEHAYNTTIIPSGHPGKQVKGLVLCGLNEVGVEAVEDYLGLDPPSYLRKELADVEITLSGGEKRTIGAVCYPWDGARTLLRPWPRDISTGSISNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB25</accession>
    <name>A0A6A6QB25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_518253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB25"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="109"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="39328" checksum="EBDC996FA75E027A" modified="2020-06-17" version="1">MSDPQVQNVSKIGIASITLRAMAAAVVRLGTSPFKGKKGASSYFKDVTFAMMRSQLGALNLAQFRYMNPWTSEVYIQFAKDTGFAPDTITLPSGTQAHWIGNKNAQKTIVYFHGGGYVLPANAGQMKFLADMKDACIAAGRDTAVLLLAYTNAPEAKYPTQLTQAIELLTHLIETEKRDPTNITLGGDSAGGNLTIGVLAHLAHPNPAVPTLSLPSKFHATFLISPWVSFNTFISSFETNAEKDAFDGRVLRLWSAAFLGSDSPFAGDFYSEPVTAPASFWEGVANVVDEVLIWGGADEVLIEGIEEFMARFRKGFRGAGGKVTTAVTERSAHEEMILDVMFGYKEKGKSHVVVEDWVKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBD0</accession>
    <name>A0A6A6QBD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_544696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBD0"/>
    <dbReference type="OrthoDB" id="3938895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025634577" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17632" checksum="60B7413D43D4B08B" modified="2020-06-17" version="1">MLSITLLSTLLLATSAFAIPLSKPISKPLTPRAGGPAFTPIPATCPVYTVLPVPLSSSPPRYAPLASVDTSNQVYAAYWDPSSTNDTDVYIGCLEQCNGFSGCKAAYIAWDVPTPAGYYGTPGGDLMTGCLMYNRTLVVGDFGVAKEGTHRDGRMGNLSLHTIPAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBF5</accession>
    <name>A0A6A6QBF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_586411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBF5"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2489336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="288" mass="31905" checksum="0CF9678670B4D96A" modified="2020-06-17" version="1">MTKAADIQAGPMAHTGALVTKTVHKTPSPALDPRKVTLPRPFVVAITGSGRGLARSEDELQAVAQTISEIVREMDGETKFSIVKCDVTVEADVKNLEKIIKEEHGRLDVLVNNAGFLDVAGWKPLTEGNPEDFKKTFDVNIYGVYLVTRTLLPVLFGSEGGAKTVVGISSMSSHFASYSISYGMSKLALNRFIEFLSKEYEKEGLMAHALHPGGVRTKMSTSEAVPTDLQKFLQHDASLSAWFLVWLTKEKRDWLSGRWLASTWDVEGLEAQKEDIVKEDKFKFRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC88</accession>
    <name>A0A6A6QC88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydantoin racemase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_553186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC88"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="245" mass="26068" checksum="961D6369A94CFD3F" modified="2020-06-17" version="1">MTNKTHERRSILIINPNSTESMTRGLEPLVDSLNFKETNHTFFTSPTGPTSINDETDAADSARHALPHLLPLLPQHSGFLVACYSKHPLVPLLKSKSPATPVTGIFEASVATALQLIAPDERFGIVSTGKVWEGILSEAVADLLGAGGSARFAGVETTGLTATGLHDAPAEEVRRRMKDAVKRLLRKDGARVGAVCLGCAGMAGMGEMVREACVEELGEEGRRVRVVDGVQAGVAWLEGAVRSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCC8</accession>
    <name>A0A6A6QCC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_162294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCC8"/>
    <dbReference type="OrthoDB" id="3942886at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20233" checksum="5E51AD79E001916D" modified="2020-06-17" version="1">MPPPRRLEAGASRRPTSTLPSLSGALHTVAASYFAIPAALVLVTVFLGCIRWAVLQHLQRKRRKARITPTPPPEKHPAPPPTASPPPSQPTVTFNPIYPWTSPPQPLPGPYDPRLYPAPTLRRHSYPDPSPTSPLHAETTTLSYTRRVSTNSIPPRHAVLHGTITTASTGATRGWRRNHWVVGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCR6</accession>
    <name>A0A6A6QCR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_166449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="312" mass="31782" checksum="25B453663FAF5B21" modified="2020-06-17" version="1">MLSLRKSLLLALPFVALVLAQASPEPIPEPSETKDVNVDQNKVFQELLNALPEESLHAALHNHHPKFKDGVWEHDRTAVERVHRENPSLATRLISAAKVDLMRRQAGNATAPPASSTPAPAAPTSTAPPAVVIPVSITTTDAAGKTIVESSSVLSAPTVSVAVAVTTTNAAGETIVKTTPAPGVVLTKTDAAGSKFVTTSAVGFAHTPGQVLTETNSRGSTFVTTYTPAGGLVSSIVLITTTGKNGQPVTLTSYAFVGAGATSTKTVGAGEQTGTNTGKPGLQTGAAGVLSRQWGVEAAAVIGGAVGMAWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCU3</accession>
    <name>A0A6A6QCU3_9PEZI</name>
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            <fullName evidence="3">OsmC family protein-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_147368</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4139202at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21142" checksum="ECA6419783E2824B" modified="2020-06-17" version="1">MTQAQSLREQQAPIKSSYRDTPNAALITLKSTGSLDSSSITCKLDTGSALKSAAKVAGLHPKAGGPDPELSGELCSGNMLLDALVACSGVTLKAVATALGIPIESGTVTAEGDMDFKGTLGVDKTAPVGITDIRLAFDLQFGLKEGGEQVTDDDVEKLGKLTERYCVVLQTLVRKPSLAVRVLGKGKEENGIERQVGWGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDB4</accession>
    <name>A0A6A6QDB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_518730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDB4"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.150">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="349"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="557" mass="63515" checksum="BBB9239BC022A732" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDP3</accession>
    <name>A0A6A6QDP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_147821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="130" mass="14833" checksum="669DAE94A736428A" modified="2020-06-17" version="1">MKDSFFVEADGRLLFCGRTHRLHAQFLFSGARSQKCQLDDLFLKALPRISQLRISSRFWDSRPLLALGHCPLNMDVWLWCLASWVLLLLLVVVRPARGKQAARSRCLSRFPAAQADLLRRLPLSDGVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE06</accession>
    <name>A0A6A6QE06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 269.34</strain>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 269.34</strain>
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    <dbReference type="PANTHER" id="PTHR33112:SF13">
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="691" mass="75414" checksum="9B202EC4F303605F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BU16DRAFT_530675</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="39401" checksum="D5BD9ED9F7217911" modified="2020-06-17" version="1">MPTAEAPVGLKTTTFSEFTKNTANDDSYNPSQGKRHRGGRNKNKSKWPKPQYEEEEEPTDVDWDAVYVQGQPTSWNQWKTSSEKYRSVFEWKQKLKSTSFSSESRASEETPSDDPTAKRQRLSASITPHSTQRSTSSSEEPAMHAGLGATFPQIQPHTAQMTDNEHDASISQPQSSKLPGKAGFAKRMMEKMGHVKGQGLGPEGKGIIESLYTQTDKSRGRGGRGGQFGGANRTQIAVIKGGRRAKEEEDDPRDKPSPVIVIFGLLDGVTRGDDEARNDGGIRQEIGDYCKIFGILEKVSPVWGTGHAQAPVFVKFGSDIGAHVALDHFNDPTKAGAFQGKGTSAKFYNLEQFELGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG86</accession>
    <name>A0A6A6QG86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_530588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU004196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG86"/>
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    <dbReference type="UniPathway" id="UPA00196"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2491016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="67872" checksum="79AACF07F71549E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGV3</accession>
    <name>A0A6A6QGV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_543017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGV3"/>
    <dbReference type="OrthoDB" id="9979965at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31399" checksum="21676BA934EB0666" modified="2020-06-17" version="1">MTTIAPTGKRRPHLSYSSHPETVEFIVGKDERIFTVTRILLARYCDEFRTAMTNGLHMKEQIRLPELSSDVFRVFLRWLHAQNTPGVAIDIFWAYGEAEWQNRNWIDAYLVKLYVFAWNYGVPRFCRAVLDVFYTRYIPMHRALPYSTMLTAFDHLPSHAPLCVLLVDIHCKRWVPRNDEDGKTMEEDLYWMDYMGVKGIDRPLQLCHYHNHPDQRVEGICKTKYGISDIKNPEELEEVGVDILRNWTGKPANFSRPGRGVEIPMVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ40</accession>
    <name>A0A6A6QJ40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_467649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
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        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="779" mass="86356" checksum="F7929502D6C72618" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QKR3_9PEZI</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="346" mass="38409" checksum="FAB31104C4686776" modified="2020-06-17" version="1">MDNHLQAQTSASNATSPPATPSTPEPFFPNGFTPYPFIPPFFRNPFDNGHRPERVPSIMKSAAPGRHYQQSPPKRDRIKRLSFSIPSEYPWEEPSIPLPSLAEFHGLIPVTYTVNVRPGLLPPPGFPLHSAIRVEDENVHALSVAAEERLRLLRKEVDERASQMLAGVAPDQLAAALQEAFDSDTDGRRPVYRRRRRGGVESRRRVVKEPKLRNPHKDAELEQEQEAPALDAYGENSPPNLQQVPNTTTPERVGGKLPRDALLALGRLVISGKKASRTVADGAYERLKAEIPADLKGLVLKPRAREREREMKEVTWWDQAPAPAEPGGGDAAQVDDEAALFDTEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM25"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025519192" description="glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="100"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="47296" checksum="4705A66E477246A8" modified="2020-06-17" version="1">MLLQNCFVVAAAVVTTCAAEHVHHRGLNSRAVAFDWGNTKVRGVNIGGWLVTEPFITPSIYLANSKTDEVHDEWTLCAKLGAAGCQKVLKPHWDSWVSLSDFQKIKKAGFNIVRIPIGYWAYKNYGGPYTSGTAPYLDNAIGWARSTGLKVLIDLHGAPKSQNGFDNSGHRFDTGNPTWGAGDSIAQTHAVLAVIENKYAKAAYQDVVVGIELVNEPLMPVIDTNGAITKKFYRDGYNNLRKISDTPVILHDGFFGPAYWNGFLTPSDNNAQGVVMDHHEYQVFDKNLIKMTPAQHRQQVCDAAGSYDGADKWTFVGEWSAALTDCAPHLNGFKRGNRYEGTWDGATRTGSCAGKTGKVSSWTQSQKDDVRKYIETQLDTFESKTKGWMFWNFKTEGGAGEWDLFQLLDGGLFPQPITNRKFGKFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMC7</accession>
    <name>A0A6A6QMC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_551281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMC7"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60685" checksum="CDC45269C844CE91" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN30</accession>
    <name>A0A6A6QN30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN30"/>
    <dbReference type="OrthoDB" id="10443259at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="210" mass="21922" checksum="936843CABB180A1B" modified="2020-06-17" version="1">MSSWNPANMVSKLNPSSMSQQQVEKQLNQASEYAQQSVDAQKGAEDAKRRVDEAVDPETKEKALKELRECEKKAKSLGKAAQRLQSGAWQGGFGGGGIGAGVGMGIGAVVGTLVGGLAAIPTTGLGILIGAGTGVIHGPWLKLPDGKQIKIPGGEKLNLPDGEEVKVENGEMYRVSDGEKIEIPEGDEGSVREVSQKARAEGLSMLIAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNA7</accession>
    <name>A0A6A6QNA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_541284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNA7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025338761" evidence="5">
        <location>
            <begin position="22"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="538" mass="58903" checksum="7E40690D84559D84" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPC5</accession>
    <name>A0A6A6QPC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_573503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPC5"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="13339" checksum="E6687084487FB114" modified="2020-06-17" version="1">MPIAAREVVVNSAQNSAGIQTLLDAEREAQKIVQKYRTKRVKDARSEAQKEIEEYRSQKEAEFKAFEKEHSSGNQKAEEDANKEAEAKVKEIKGIGSKTGSKVVDQLLAAVTDVNPKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPE2</accession>
    <name>A0A6A6QPE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_464565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPE2"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="29076" checksum="BA223199F616DBA3" modified="2020-06-17" version="1">MSIKKPFTLPERFLEGPAPAIKVSKIDFAKSTIPEYDNLWAVILDDVMTPAECKALVNAAEATTDGKWERAMINVGNGRQALYEDTRNCGRIIWDDKEIVAKLWARVEATVPELQYLENWPKVTGIGPQKRKETWRMTRLNERMRFLKYSSGEFFRPHCDGTYETPDFKERSYFTLHLYLNDASSDPKGQSLQGGSTTFHAFDMKRRIDVEPKIGRVLLFQHKFLLHSGDDVTRGTKLTMRTDVMFEKDRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPF0</accession>
    <name>A0A6A6QPF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_619419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPF0"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="150" mass="16977" checksum="98FD7A1DAD7668CF" modified="2020-06-17" version="1">MRFYDIHHHCALEQIQRDEIASRITALHCMHFTTPSLFVNIRITQADTKDIAAYVGGERVGINYIHVHIRPRKSHPDSEVREPYNSLIIEIAAIWQDVLGCSAYRETGSLENPADLHSVFTLDDIAAGYEQGFLLPEAGGDTRWVEENMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPG9</accession>
    <name>A0A6A6QPG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_428785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPG9"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="15273" checksum="40D233C9134429C9" modified="2020-06-17" version="1" fragment="single">RAFTTSPAALAKNRLYANIRRPDELHTLLLLSASSNVPLITLWSASWCSACAAVRPVLKELLETEGVGEAQGGLGFAEVELDSVEIGTLGVDYMINSMPTLLAFSRGEAQVETKLTRPEEMKDRERLREWLEGEARRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPM8</accession>
    <name>A0A6A6QPM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_563816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPM8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="701" mass="78356" checksum="29E17D2B3EB94438" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ89</accession>
    <name>A0A6A6QQ89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_464435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ89"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="572" mass="64319" checksum="5F1B90AF205812AC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQL4</accession>
    <name>A0A6A6QQL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_562334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2494695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="87"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="51911" checksum="73B43D3B18D2E90B" modified="2020-06-17" version="1">MPSHLLLRRAQRAFAELRIRRQRSLATPLRCSPLSTLQLAAPENVVVPCRSNGAVTLSIYRSRDLTQPTPVLIYLPAGLALPGQSDDYEDASISALLDSSSSTVVRINYRLSERHQFPTPVHDVLTAYDWILHNLVKSSTTGPTNGRTASRLARLGVYGELVGGGLAAMLALTECKLGASRIGAAAINNPVVDWVFPDELAAIIKPEPRPGHDHQDESYEHNSLMDWWAQQEAEEEATPKSPKRVPKVAKSSWKDYAHNPALPTSALLQSREVFFKKKEDYFDRFASPICFFRSPKGELVYPEHEDILASSSPPTSDDDSPSLDPDLSFQEILSEADSHKPRPAPALPTLLRCRAYYRGFPPSHLDLDLPFMHITTGSESPLLDQASEYSGMVKRAVAHQFTSNRHTRDTRDSQEIDQLKAKAQEIADRKVSLKVQDGLGLLTGSSSSERWKNGVEEVGSWMKARIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQQ7</accession>
    <name>A0A6A6QQQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_527731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
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    </dbReference>
    <dbReference type="Pfam" id="PF10602">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="228"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="53542" checksum="544402F4B1C9A9D3" modified="2020-06-17" version="1">MGDPQFAKYPNLQLSQHVFQLTNPSSPKASKQASLKSLQDAIREHKMAPLYRHLAHPVEGVLNATGEGTASQPAGHRRPSSSAATFLATKNPTLEVSLPWDEKLYEELKTENEKELEAIQKEEDEAAEKAGETEVQTARGKRAECYTRIGDKEKAIAAYEAVFEKTGILGTKIDIVLAIIRIGLFFGDKILVKKTVERAGTLVESGGDWDRRNRLKAYQGLHLLTVRSHAQAAPLLLDSLSTFTSYELCNYSALVIYAVLAGSVSLKRVDFKSKVVDAPEIKAILGDGDEKSSALSGKTSAGAGAGDEEMQDGPASSATPHAAVNLTTIGQSQAEQQDAEAPVDFTGLATLVGSLYNGNYKDFFGALASVEDAFLSQDRYLYEHKSWFVREMRLRGYQQLLQSYRVVGLTSMANDFGVTIDFLDRDLAKFIAADRIPCTIDRVKGIIETNRPDDKNKQYSDVVKQGDQLITKLQKYGQAVRLRGSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR09</accession>
    <name>A0A6A6QR09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_618807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10666015at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="28556" checksum="DE2E0171B548ACE0" modified="2020-06-17" version="1">MKGFFQKAKDQVASLLQKDPKVPPPVPATRPSIFGDGTQKDLKIPPPKSIHTLPSTNQMDPPSPSEDADDTIEVNRDSLEMFGELAAGEWLSESPDGDNGSRQEQVEAILSEALERIQQRIPDGTMFSVPDLVQEIRDAMGEIESDREDEEHIRDLEQQLEASKQRYRYLKFMHDWDEEDIPKAKEAVVKAKKDYDAAQELFLEEERKEPHGEKTLAAKKECYAAYDRWMEGREKVAKLEEELEEARKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRZ2</accession>
    <name>A0A6A6QRZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_592078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRZ2"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="524" mass="59646" checksum="BF8FF92F76D83636" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSC8</accession>
    <name>A0A6A6QSC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_385864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="32"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="522" mass="58405" checksum="6ECDEB107EDCA0EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSF4</accession>
    <name>A0A6A6QSF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taud/tfda taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_549967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="369" mass="41166" checksum="297CFE45D40E0FD6" modified="2020-06-17" version="1">MATTTSTTTLEDSDLTLEVFDIPDSRIVHGKAFPLGLHPKDGAVPADIDSAVGYLENIAKTGTFRSLLSQHGVILIRGLPIKNAQDFSKFVTAFQLPQPHREVGLAGKRTTVTTNIKTANEEPPDVKFYYHSEYGRSAYFPGVLFFFSEKVPEQGGQTPLLSSLELYDRLAADLPEFLKDLSEKGIIGRQYFPAKDDPEAGHIGWNWKDSYGFEIKDGDSLEVQREKVEAVLRDTLQAKAEWQPNGALHVLQHLPAIRRIGSTGKPTFFNGFAGVYGRGRDNNALEPPYRGKDEKYHLPTTYGDGTPIPVEFQERLLEISDDIGFLTPWQPGDVALIDNFTVQHARTPWKGDRSLLVSLWDGHEKFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSK0</accession>
    <name>A0A6A6QSK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_461096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="29"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="747" mass="84173" checksum="100C72892E138678" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSU1</accession>
    <name>A0A6A6QSU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bli-3 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_462146</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="434253at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="207" mass="22134" checksum="1F114E1DAC721CAE" modified="2020-06-17" version="1">MSFSNADTGNKAADPYKEKNIEVASLKDKVEDLVAFIDKSKFCMMTTRIESSGLLASRCMALAAKEGGGVDLIFHSNTESGKTDDLASDSDINLGFLNSSGEWASLSGKATISTDRADVEKYYSPALKAWIGDLGDGVHDGGPSDPRICLIRVKTVTAQYAISKRTVIGGLVELAKGVATGEAPSVNRLRYLDEAEIAQCELQLKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT12</accession>
    <name>A0A6A6QT12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mandelate racemase/muconate lactonizing enzyme domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_572568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT12"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DgoD-like"/>
    </dbReference>
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        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enolase C-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Enolase N-terminal domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="381" mass="41885" checksum="7820A8A8966E30BA" modified="2020-06-17" version="1">MGKISTIEYFRVPPRWLFVKITDDAGNTGWGEASLEGHTQAVEGCLDAWIERYIGFEADEIEHIWQMSWRTSFYRGGPVFMSALAGIDIALWDLKGEKLGVPIYQLLGGKCRDKLKVYAWIGGDRPGDIEKQALARKAQGFLSVKMNGTEDIGWLDSPAALNDCVERLKAVKALGMDAGIDFHGRVHKPMAKQLAKALEPHFPLFIEEPLLSEHIGGITQISQLTSTPIALGERLHSRWDVRPFLEAGCVDILQPDISHVGGISEVKKIAAMCETYDVAVAPHCPLGPIALAANVQVDAVMPNFAIQEMSLGIHYNAGSQDLTSYVKNPEVWDVKDGYIELLKGPGLGIEVDEAQVRELSRNAKAWVSPGFIGPGGEVREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTB2</accession>
    <name>A0A6A6QTB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_610325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTB2"/>
    <dbReference type="OrthoDB" id="10481623at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="604" mass="67203" checksum="9B8760D9178C56AE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTG0</accession>
    <name>A0A6A6QTG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_459729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTG0"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="322" mass="34123" checksum="8519B4F6EB16C918" modified="2020-06-17" version="1">MDFHKPVNPSNLFSAERLVVVITGGGSGIGLAIAAALHQNGAKRIYLLGRRREVLDEAVKTLTSSPAAPRATSDDVATIVPVPCDITSPGSIKAAVAQVESTDGYVDVLVNSAGMIGPKHLDFYEQDSIEGLRDVMLRDWDLWETTMATNTSSVIGVSAAFLPLLEAANRRRGWETGKLTRARTQTLSKKEEDPQAKVDGDDQRLAHIITIASVGSFMRKATAGLAYNASKAAAAHLGKMMATMFAEWGIRSNVVAPGPYPSDMTTKMATAFPPSELPAGRMGSETDLAGLILFLVGKGGAYINGTVQVTDGGRLGVFPSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTP4</accession>
    <name>A0A6A6QTP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sister chromatid separation protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_572778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTP4"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="13">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="12">
        <location>
            <begin position="327"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2495484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87380" checksum="42D3AA698574CADD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTS4</accession>
    <name>A0A6A6QTS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_527335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2495532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="517" mass="55942" checksum="16CE6F4CC78901C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTW6</accession>
    <name>A0A6A6QTW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_358575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Lophium</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="162" mass="17268" checksum="559ADCA509DE90C7" modified="2020-06-17" version="1">MTFFAADSLTALQHPSPTAAVHDSTYQLAGAATRCIPLLPPASDDCDSGARPPSRCPRRYKPGTPAALSPRPAQFTASLRPSTLHRRAEGNMWLAVHAVRRTPIDRERAMYGQGPIPNRPGDRPTLTSASASESAGSSVQRLSSGSPCLLKAGAREGFYRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU28</accession>
    <name>A0A6A6QU28_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_617440</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03357">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25311" checksum="B48F8EC416684A7B" modified="2020-06-17" version="1">METIRGLLWKPTPEEQKRKCNALVRSNVRKLEREIQGFKTAETKAKALIVEHSKRAQRASPNSGAAIRERDATREFARSLITIRKQNSRLLTGKAQLQSVQMQVNEAFSVRKIEGSLRASTGIMKDVNSLVRLPELTGTMRELSQELVRAGIIEEMVGDSLPDSELLEGEDDAAEAEVDKILGEILKDRLPASAEKPVDSVPTVPVTEENNEEELKEMKGRLQALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUP3</accession>
    <name>A0A6A6QUP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUP3"/>
    <dbReference type="OrthoDB" id="3762912at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="409" mass="46270" checksum="E32755979EBFFE6F" modified="2020-06-17" version="1">MATYRHRNPTRPSPATVSVTMEPDQLNRDLTSAEIRILTAASLISPSPNPGMRTVSAAALYPTTSTKTLELPEHMTSVAAMEHVGFTPAAATQVFNNYYTCPDPDNYPYGLISHAHDKVKHPRSMAQVGLRTEFQDALLDPTFKDVLRTNTLLYWVQATLSGRYRMLSDLSVRLKRLAERLEGNSAAARCRGVEMPEEVMRRPPPRPEGECYLLYKGQAARTVWYAGEEWEKDGSFNMRQLASLPVPPGDFNGRIPAVYFNLEAETAELYRAWAARRDQYCETLMIRVELPKGYVDGLKQEEVFYGKNWKDLAWVHPSLHGTRFREYREAELIKGHVCTGVQKKRWMKVEEVQEKISKKNAMKVPERDEEVMAVQWAFLSAEHEGLGVASAGNVFVDVIPPECLFGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUR9</accession>
    <name>A0A6A6QUR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_508612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MPAB"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="49144" checksum="A52804B40E918257" modified="2020-06-17" version="1">MASISEKWSFDLSFITERLPSWPISALALVFSYSLLCRTLRFRRMKQQHAKFPYKTRESYSRMTATDAFEISKYISTLEFPFLSEKAAAFALFRTYGIPTISKTLCETKQFSEPVFASKRYADTGVLINEFAGNAPDSDRSISAISRMNYLHEGYRKAGKITNNDMIYTLSLFVLETDRWLRSYEWRPLTDMELCAYGTLWKNIGDSMDIDFTALKHGPNSFQDGLEFAHDIKEWVEDYEEKHLVPDSWNHKLANETTNILIYNLPGFLKGPAKRLVTTMMDERLRKAIKYPEAPAPYHITKNIILATRKFLLQNFFLPRPYFLRVVAFTEKPNSTGRYESTTYETEPWYVPETFRNRWGLEAWVRWLAGRPIPGGGKYKPEGYHMHEVGPKKMEGKGLEHYEAEREKLFAAGKGGCPFAVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVX8</accession>
    <name>A0A6A6QVX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_549843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="594" mass="65320" checksum="16780E9DF6C5DE41" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVZ0</accession>
    <name>A0A6A6QVZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_365211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVZ0"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="411"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67785" checksum="1EE5FF90B7881003" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVZ3</accession>
    <name>A0A6A6QVZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_526870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVZ3"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="160"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2496376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="460" mass="49967" checksum="F1D316DBA015E75D" modified="2020-06-17" version="1">MAAALSRKAVSAPGKVLLAGGYLVLDREHTGLVFGLDARIHVHIEPLQTSQGVVLSEIIVKSPQFLNANWEYGYRLTEGEGGIAVTQLRVSVDDPLLRNPFVETALSYALTYISTSLPHHLIQPASISIIADTDYYSQPAKRSASNSRFLNFDVPLWDAHKTGLGSSAALVTAFTGALLAHYLPKSRFDLTTDTGRQRLHNLSQAAHCAAQGKVGSGFDVASAVYGSCLYKRFSPSILQSHGEPGTPLFSKKLKALVDENGVKWDTEIVKSAVDIPKGLRLVMCDVDCGSKTPGMVKKVLQWRKEKPEEAEKIWSELQKRNDGLAAELVRLSKSNSTEYSELRECIARIRALIREMSEASGVPIEPEEQTQLLDTCSKIPGVVGGVVPGAGGYDAVSLLVENKPDVIESIKKALADWKVNEGVDTGAVTIGKVSMLGVREEMEGVRLEDPTMYGEWVEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW63</accession>
    <name>A0A6A6QW63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_538546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW63"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="37971" checksum="82C538B4CD6AA501" modified="2020-06-17" version="1">MAESTHSWLPSIPYPPAQEGRWSPVTSTLNWCEEDYYATIYSAEIVNTLTNLLFMYLAAQGIRGCLKNGHDGIFVVTFIGYLLVGSGSFLFHATLKCMFGPIQDPMQLVDELSMIYTTCLMCYATFSHGKSKLYSTVLAVSLVSLSLFITLYYHYLQDPTFHQNAYALLTATVVFRSMFVMEVNIRPKFKAKAAREVQRATAAGKAEQRRQDQRDKDILRQMWKLIGCGLSIFIGGFAIWTVDNEFCLTLRVWRRQIGLPWGILLEGHGWWHIMTGIGAYFYIQWGIWLRHCLNEKQDNYELHWPSLFSLPAVVRQQNKPSNGQVGSTTKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWQ3</accession>
    <name>A0A6A6QWQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_458074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWQ3"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="117" mass="13152" checksum="F947F9E100AD079B" modified="2020-06-17" version="1" fragment="single">VIVHEGNGFCYACPIFTYSNRATTKPGCRPAEHAIIYYSTLQSPMHLRGETGMTKLPIGVLPSQPESRPMSTASRIRFSKVYPIDWGVEVKHLGQVIDEHLPRLIEYYREEGGTVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWQ9</accession>
    <name>A0A6A6QWQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_431394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWQ9"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="165" mass="17897" checksum="F9838C1EDF6FBBAA" modified="2020-06-17" version="1" fragment="single">QNSKSLRRLATDHASLHTAGLPPNYLFPPSSNSSHDPTADLTHLDVLLAGPPGTPFASGLFALHLSIPPTYPVHPPTATFRTRIFHPNVDEATGAVCVETLKRDWSEKLKLRDVLVTISCLLIQPNPESALNAEAGRLCAEDWGSFERRVKVWVGIHAGVPKGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWV0</accession>
    <name>A0A6A6QWV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_526673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWV0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="176" mass="19840" checksum="B46085D880274B68" modified="2020-06-17" version="1">MKRSRNDFRRHQARRRLLGDLKGHLSLAALRRAGWPVQRTCMSFDPWTQTETHAQNRQPILPSHPRLVPWELPRLAAQKPMLPRNLSHELPCQSPNRCRQLQVDAAAPLARLPSGGCRVLHLELYRGLAGLRALHVLVLGRTSSPTDFRYVAAPIFFCQGAKTAVCIGAVQYLATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX58</accession>
    <name>A0A6A6QX58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_460873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX58"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="601" mass="68016" checksum="8675E14A455CE9EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXV6</accession>
    <name>A0A6A6QXV6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_485214</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="206" mass="22293" checksum="A42C24C4402B5B90" modified="2020-06-17" version="1">MAAKIAIINTSTRPVRVGPSVTAFVKELLEKADSSANITTVDVADFNLPVFDEPVAPAMVPAMAQFTKDHSKAWSAEIAKYDAYIIVANEYNFGMSGSTKNAIDFLYNEWIGKPIYIVTYGIMGATNASEQLKAVLTGMKLKVVETRPNLGFHGAQAGPDMYGAIKGELGEASKKDWETEKKEELVKGFTELKELLASPPKAEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
    <gene>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2497114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1700" mass="190851" checksum="D82A459164ECC358" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYW4</accession>
    <name>A0A6A6QYW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_457272</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYW4"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="426"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2497429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="630" mass="71361" checksum="DC6710DE46FE8C3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYX0</accession>
    <name>A0A6A6QYX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_606245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYX0"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000286">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF87">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
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    <sequence length="395" mass="43758" checksum="1A219D9CD9788611" modified="2020-06-17" version="1">MRSLAHTVTLALLRVGLVHSLSAQTPQMGWNSWNTFKTNFDQSTLQTTADLLASTGLKDAGYTYLIMDEGWQDLERDSSGRQQPNLTKLPDGVPGIAKYVHGKGLKLGIYSDAGIYDCGFYPGSYGNEELDAATYASWGVDYLKDDNCGGFYANTESPYTRFAVMRDALKTSGREIFCSLCQWGHQFPWYWADLVGQSYRMSGDITSIYSDTGKDCPVTGCSVLTIIRKMRELSRFQKKGAWADMDMLEIGNGNMTLRQQQTHFSFWAALKSPLIIGADVSKLAADSLSVLKNEEMIAVNQDSEGEAMHYLPELSVEKQSQVWAGALSRGRTVVLVLNEGNVTSAIEVELAKIPGLNAWKLYQVRDVWGVKSVRNIKGVVNVTVEVDETKVLVFS</sequence>
</entry>
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    <name>A0A6A6QZQ7_9PEZI</name>
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            <fullName evidence="2">HbrB-like protein</fullName>
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        <name evidence="2" type="ORF">BU16DRAFT_525512</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Bit61/PRR5"/>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KAF2497935.1"/>
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            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
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</entry>
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    <name>A0A6A6R1C0_9PEZI</name>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="36313" checksum="DBDA32755F01435A" modified="2020-06-17" version="1">MSTIIITSEVVIVPTVSSYSPSTVVVFITAITTPASTSSYYTSPTSSTAATTPIVTASDTTRPSHTPSPGLSIGAKLGIGISIPLAVVAIAFGIAFFFHRRHKRANSTPGSGDTETTYANLADKPLPLVAELQGHSTVPSWRAPDARPVIHELPGTPPTATGYYRPNSASSSVHELRQVDAAQKPDARELQRQASLAASEHVPHELSASGSRQATNVPPLPTGSPTVAPDPLVSSTVQPSRSHNTTPPPTASEITDHPRRPTSPIDDNASVHVSRHASAIASRTTNDDAELAQIEEAMTRLRNQKKLLQELRDVERQEADMERRRKELRMARDRGGGGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R1F9_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="38048" checksum="AB26E53867F0B3A0" modified="2020-06-17" version="1">MPSRSSRAHLMAYEWPFTQQDTEGWHESDAGEAISGMISPTVVPDAKASDLLATAAGSCKSPPRPRPGRRGVTDARRDSGVVLAASVSSHESSRCAYGRIVLFVAIRVARCGSCPQTGSNAWCRPPAIGEQRELQCGPASLKLPGQAAVGETRPRGEIGSGWARAQQVKIHQQQRSLAMFRQASSWSACPRAIERRGFKVARADETTRPPGNGAPKLRVVLSSRSSTLEPKRRAKRGRDERCAASVSTRSSMAGSEFSRPGPARQDTQANHRSDGRPRAGPVHWTSARSRTTLPLPAPVLPALWALNTGGNGARGPCGREDGKRRGLMASRFAALAAPAGSGLSGHLSAQQGTGAVARS</sequence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R1T8_9PEZI</name>
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        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_558555</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1T8"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2498499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="506" mass="56274" checksum="C37AD09737BB1FD8" modified="2020-06-17" version="1">MGKKEKSSFQLKTPKGTKDWQGTDMVIRDGIFSKISEVFKRHGAVTIDTPVFELKEILAGKYGEDSKLIYDLADQGGELCSLRYDLTVPFARWLAMNSSVKHIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGEYDSMIPDAEILRITSEIFESLGWQGKYTIKINHRKILDGIFEVCGVPTDKLRTISSAVDKLDKSPWDEVRREMTEEKGLDPEVADKIGQYVNFKGARDLLTKLTEDTTLYGNASAKKGLDDMATLFDYLEVFGVLPNVSLDMSLARGLDYYTGVIYEVVTEGSAGDSTAKKPAKKDKKPADADEDRSSDPSVGVGSVAAGGRYDELVGMFSGKGQIPCVGISFGVDRIFSITKARMAKETELRPNEVDVYVMVLGSKGGLLKERMEVATLLWDAGIKTEFSWKVKPKAPPQWKAAENGGIPYAVILGDDEVRDGKVTLKKFGLPEGHPEKNGVLINRSDLLAELKKKLRALSEPELEEKVAELTVQDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2D4</accession>
    <name>A0A6A6R2D4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_524910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2D4"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025408776" evidence="3">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="245"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2498875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="370" mass="40734" checksum="44E402FE5CBEC6E0" modified="2020-06-17" version="1">MKLILSILVCIAAIAVYHQDYMLSRLSQLTRTITPTKATSQLTKSAAMSSSTTFAGLPVIPPTDEPLTTINPRKIAKTFLAIEQSEGAGARVRRSIGTPRLRNFSPFLMLDHFAIPPGAGFPDHPHRGQETITYLLDGAVDHEDFAGNKGTIEKGDLQFMTAGRGIVHAEMPRQNVDGAPNVGMQLWVDLPKALKFCEPRYRDLRAKEIPEVNVQDGKVKVKVISGRSYGTDSVKELAYTPVWLLDFTVQPGGKVEQALPKGWNAFAYTLSGNTIFNSGNESRPVEQYHNVVFEQGGDSITASVEEGAETESRFILVAGLPLDQPVVQYGPFVLTSRDEVMQAMMDYQGFSNGFERAQDWESEIGKTMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2G6</accession>
    <name>A0A6A6R2G6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BU16DRAFT_548411</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.700:FF:000001">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF58">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="22">
        <location>
            <begin position="47"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="452"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="520"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="836"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="625"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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            <begin position="903"/>
            <end position="970"/>
        </location>
    </feature>
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            <begin position="1151"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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            <begin position="1430"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1591"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="903"/>
            <end position="919"/>
        </location>
    </feature>
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        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
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        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
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            <end position="1197"/>
        </location>
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        <location>
            <begin position="1198"/>
            <end position="1210"/>
        </location>
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        <location>
            <begin position="1241"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
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    </feature>
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            <begin position="1325"/>
            <end position="1342"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1464"/>
            <end position="1506"/>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2498739.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1635" mass="178448" checksum="470F0AE36E22E043" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R371</accession>
    <name>A0A6A6R371_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_604258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R371"/>
    <dbReference type="OrthoDB" id="5410873at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="425" mass="48240" checksum="361029B5037F5150" modified="2020-06-17" version="1">MPSSQHAYNTAKASMACPLFDLPDELQMMIVHELSDDDNDALINLSSTCRRYRSLLAPTVFRTITLKNTVTSATSVLAVSKSQHAQLVSRLTFVGTLAELDFAVDHDEYRNCTIKNVAKMVLDDDHLKKIIPRQLYEVLGNLTLFPNLHTLTVGFELGHWPGDPWTDIIDLLDGLCAYSDKGFDNNADDKKYTRHGQSDPDSIAFCRGYIRFCENLSEYFFDHLEYAETLNIIAPESGRLGHKDGGPLTLNTSHLPHLKFLYLEQIFITGELGTFLLARTDSLEELQFQDCYGTVTNRYSKNTTGLCAWHRIFDRISDSRPKRLERLEIRPWQATSFQHITRNGPTRPVLSLVENRSLAHETLESDPERAVFPYGNFRFGLFRNSFYVCDDSATTEFLNGDDQEAYDRLKVILEANKANCTAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3S0</accession>
    <name>A0A6A6R3S0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_558999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3S0"/>
    <dbReference type="OrthoDB" id="3795368at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="42623" checksum="47DFEF961C94A8EA" modified="2020-06-17" version="1">MIYMKHKVPSLAEGDDRNLKDHTTDPVSKQKARAHVSLTFITFDKPTVRIMGFRPIRNPLPKDYIGVMKAGEGAQGYTYFCVPKHALESSTNHEQKAETLKGQLCVVKITKYVHDTREVTAMKWIKELRDAPTNRFVGLFDEGGLDETAGRWLAMSPILGPSLREFTMPYSQPRKSLPMEFVWHIFHQVFEGIGYLHSRDPPVLHGDFYATNIMLDPIHQDFFGFPNVVIIDFGSAKILHPDALFGLIGPKELHARDAWSAYDLIYRLTSMSIEKPVVGTLADQWEQFTEALDDMRLATGLTGSTQEDIEGWETYLFLEKWKKVAVEARGKTPPEVFEEIASGLKTTEINEKLDASLQAVVKRHGGGKPGIHQISPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R468</accession>
    <name>A0A6A6R468_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_579658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R468"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="108" mass="11857" checksum="E7CC0AD3BD71C342" modified="2020-06-17" version="1">MTSRRIISDEKTYLDKDDDKDNSQPSNIAPAVPAAVIWKLLGFTFAMITMPIGTYFLTVNAVFKGNSTFAGALAAIIANVVLVGYVVVAMKEDQSERLEEEEKQKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4L2</accession>
    <name>A0A6A6R4L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_454289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="640"/>
            <end position="686"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
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        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499685.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="779" mass="85899" checksum="A9800DDE208CD8BE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4U6</accession>
    <name>A0A6A6R4U6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_557876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17047" checksum="4AF028ED345EC364" modified="2020-06-17" version="1">MASPTATSTGPVDSPREKKTDSPSSAKYSASCHCGAVCFTVTLTPPLAQQQPVTCTCTICSRNGYLLVYPLRSDLVITQGADDLKSYSFGRKRNLHQFCGRCGSSVFFDPRMAEHGEGPDRMGVNVRMFKDIKLDELNLRHFDGLNLFPFIDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R568</accession>
    <name>A0A6A6R568_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar ATP synthase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_524152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10263003at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="25948" checksum="42381DD43F3FB99C" modified="2020-06-17" version="1">MSQVHAMSDDQVAGELKKMTAFIRQEALEKANEIRLKADEEFAIEKSKLVRQETAAIDSSYEKKFKQASMSQQITRSTVANKTRLRVLSARQEVLDDLFLQAGKKIPDFTKDKAKYQKIVTNLILEGLYALNESKVQVKARKADYDIVKKAIPDAQKEYKKNVEKEVAITIDESDPLPEGSSGGVFVVGTGGRIDINNTLEERLKLLETDALPSIRVTLFGENENRRFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R597</accession>
    <name>A0A6A6R597_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ethanolaminephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_524726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R597"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="48103" checksum="24DE44919DDD14E8" modified="2020-06-17" version="1">MSLPLPVTTSPNMKPSSKKAAHECVSDEALAHLKTYKYSSVDKSLISRYILKHYWNGFVELLPLWLAPNMVTLLGFFFILGNVALLSIFVPDLVGPGPSWLYYSFAIGLWMYSTMDNVDGKQARRTGTSSGLGELFDHGIDSLNCTLASLLETAAMGYGPTKTGAFTALIPCLPMFFSTWETYHTHTLYLGYFNGPTEGLILACTIMILSGYYGPEMWSTPLIAHFPSLEPHIGQTTFRDLWVPILISSFLIAHLPACIVNVSKARRAQGLSILPLFVEWTPMVIFVASTAAWLGSPHSNLLTDNHLVLFCLTMSLVFGRMTTKIILAHLTHQPFPMYTVMLTPLIIAGVAINFPYFPIIGDLFAPISAQTEYMYLWCYFVFAGIVYANWAVLVIGRICEYLGINCLTIPSKSPVSEKSSISNGGTNGSLGKGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5L2</accession>
    <name>A0A6A6R5L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS drug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_455181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5L2"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="565" mass="61488" checksum="6B06466E7C6D5211" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5S3</accession>
    <name>A0A6A6R5S3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_284424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5S3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="26118" checksum="8CD57193C984F9F6" modified="2020-06-17" version="1">MGSQPYLPSTSWVRPNSRGITNDPTDCRLCSKMKRNSFLFRQFQPSSEYSILGFCICHLRRVIEPSHRLQRITLLESQPCRATPYDISDYPPPAANIHDSPTLSWVRTYGLSRISTWPRRVTLGGGLDHWGGRYLSERRPIALLRSNLKLSGELVGLQRCPAVVIDHLHLHLRIFFHSIGPTCSAQDLARWPREELSTERCLHRSRRNHRSRARGMNHAARQGSRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6R7</accession>
    <name>A0A6A6R6R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_478866</name>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="768" mass="85656" checksum="370D09B0FEB01199" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8Y5</accession>
    <name>A0A6A6R8Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_535415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2500882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="466" mass="52232" checksum="14CE08F24A0A1205" modified="2020-06-17" version="1">MVSIETSLPIVWRSNPHGNEYERARVGRVFNARRPKRFPRAVVEATTESQVVEAVRLAIREKCRVSVRSGGHSWAAWSVRDDAILIDLGRYQHLELDEGKKAIIVSPSTTGRVLNGLLSTRGLMFAGGHCPDVGVGGFLLQGGMGWNCKNWGWACEQVVAIDAVDAWGELLHCDTEQNSDLFWAARGAGPGFPGVITKFYLRVRPAYTNVLNSLFFYPISEYRRAMDWVIKASPTFDEDTEIVAIGAVAPPETGISGHCVLLNFLTFKNDEEEAKSALLPANTGRPQGFALELTNQPSSLADQYRIQAGANPEGHRYCAENAYIKNDADVPAVMEDAFTTAPHPKAFCIWYAMAPCSRRPLPDMALSTQSDHYFALYTVWEHESDDERCQSWVSNTMRKVERHSDGAYLGDSDFQVRRTRFWADANAERLMDIRRKYDPEGRICGYLDIDDASGVKGLENRHEWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R911</accession>
    <name>A0A6A6R911_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_195605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4524197at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119007" checksum="C48AF27D6B1ABD7E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R999</accession>
    <name>A0A6A6R999_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R999"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="59" mass="6411" checksum="E1997DB5AD7534AA" modified="2020-06-17" version="1">MRADTAALAGAGRLSTFLLFLHTLGIWTHPRLLQGPGTASQLGLQQWTVQLVVWAQKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9B7</accession>
    <name>A0A6A6R9B7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_569845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9B7"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="382" mass="41842" checksum="BCEB6A4234F2252E" modified="2020-06-17" version="1">MVGVLSTSQTFAPFTFAGQKNTQTLGFPNDAEFPLALKPAGSWQPTLQESVTAIEGLAKSGQISSLAQKHGGAILFRGLPIKTPQDYSEVAHAFGFRAHEEVGRPPLRTVLAKNIKTANEGPPELPIWPHNEYGWSTINPAWLTFSAMVTPEQGGETPINSSIALASALEKQAPEFVQTLLNKGVRYVYRYGVQEVKSNTGTSVLGAYGQTVLPGDDAETVRRKVEAEVRRHSERFEWHEDGSLSVTHVVPIIRKHEKLGLTTFFGNLTSAWGRSKHYRATEPPYLGSDGSYHPIPEYGDGTPIETKYLDLALAIAEDSQVLLTWQPGDVVLLDNHAVQHSRSPWVGNRTVLAALWDEDGKIGDFEEGIEILKSSPRVPIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAG7</accession>
    <name>A0A6A6RAG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_522499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAG7"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2501541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="259" mass="28512" checksum="BA1C754E4265B5C4" modified="2020-06-17" version="1">MAEVASAQQPVPLDTIPISPDGDKSTSGTDNSKSNGSADTVDDAPVTVFHDPDNFNVKHPLMNTWTLWFTKPPSGKGDNWNDLLKEVISFDSVEEFWGIYNNITSTSELALKSDYHLFKKGVRPEWEDSQNKHGGKWAFQFKDKKAINIDALWLHVMLAAIGETLEEDGDNEVMGVVVNVRKGFYRIGLWTRTVGKAGDGKNGTAKARTPEQGKEVLMRIGKKFKEALGLESSNEVVEFSGHTDSAHAGSTRAKAKMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAP0</accession>
    <name>A0A6A6RAP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_207772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAP0"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="362" mass="41905" checksum="4B89880A5AC9DBB8" modified="2020-06-17" version="1">MHLRTFQSRAISYRTSMLKRYLQQMKIIHGKMASPEGLEYRCMPRPWQDRRREWRNAAYRKATGESFDGEVVEIGGVDEMKKAQEENKKFLEKTPAEALSWRWSVTKMANYLVNTYKDEAACRDPDNFDMYIDMYFAGYGLQEVIENQLVAFHEEYKKENCDPHRLFVRMEAMAIWLFTSDLCYWTGLDDGARVSATMDIIGRALLTSLNALERADLLGPFSKVKNIPMVLSMFLDFADDEEGTTAMQFDMNGDESPQTWPYFVVAYINAHGIDIEGKGLYGIDSIADGYDDEEVADFEDLEPGPDQWGFNAAFETFATYWGVFSGQSNEYDIVAMEPEKRIEYAFDRQDPLDRMDPDHLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAQ1</accession>
    <name>A0A6A6RAQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_569681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAQ1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2501779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="365" mass="40931" checksum="9396CCAB09A6EE32" modified="2020-06-17" version="1">MAPSLETPEATPVSKAQQRRKPLKPTRLLDQFKQRDLTAVIGTEFHDINLVDWLHAPNSDELLRDLAYKISERNVVVFRKQDALNNDLQKELVQRLGELSGKPSTSKLHIHPTVNIGASDGATKDKEISVIDSTRGRIIFKGVQDRETIKASNTDQWHSDITFEPVPSDYAVLRLTKLPRTGGDTMFASGYDVFDRISPPYQKFLESLTATYGQPKFGKAAAINGYKLFTEERGAPENVGDDLSAIHPVIRTNPVTGWKSVFSVGHHVQHINGVTEQESKALLDWFLRLIVENHDLQVRVHWDNENDVVIWDNRSTYHAATPDYQGLGTRTGQRAVSLGERPYLDPESVSRREDLSKTTTAGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBB9</accession>
    <name>A0A6A6RBB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein HSS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_546817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBB9"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2501656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="679" mass="75236" checksum="7A2B531051377CCF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBY1</accession>
    <name>A0A6A6RBY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBY1"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="47404" checksum="04E0BB4C40BC3E38" modified="2020-06-17" version="1">MPSASSMVSSNVQSLEDPSRPADHAITHESGTSSGDDGTALSFLVHGSAYIPMFDVITQYLEPRDIIALRGVDRALAANDVFSAAQSSQWNIDTALSEFFKSPVGFRSALGQVQAVVTGEFVLRFLDRRAPGERIDIFMSEEEPNKETLTAFLQNEGYDQHGGHTHQAPARNRLWTGVDRYVRKRPTGVHPTKLYVKYTVGPPVVSILKGMQYTTALANVITATKAYVPFAEYTIKERRSYLHGMLHDSDEEMPAALSVASESGRDLRDHIVAASSIHGSTEKPTPARCYRTLADGKTWVIPFPTDGLVTPKEPDFVIEATDFSVRVDTNDAPGHDRFIVALDALDFVGLQYSWAGLQLRSVEVMRRLRYLLMLEIGKLPKEDWPVDLMDFMFRGLHSRSGDFVPPTWLDDMVAEWAGKIAEGKQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBY6</accession>
    <name>A0A6A6RBY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_613187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBY6"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="260" mass="27722" checksum="584CBED230225BB2" modified="2020-06-17" version="1">MSSPNRTLLPSPFPDEATSNPRSPSPHQTQDAVPEPSPNEPYPEAEADASYVEPTSTTLLPPPSFSPFFTLIEDAATGEHYHPSLHYLFADDDPILLTAASMRALGVDEAALLSDPQQPDSPDDPDDIRESPLPPPLPGVTERYLVVDVGADGQAITDAQSLSTEWQVTETAVRAAPSWDEEAGGEGLMLVVGGVEVKQVGKRVGAPGEARLAEARGAVGGNVLAGLEKIVGQFDGELEVLRRVVGEKEVEREGLERRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC00</accession>
    <name>A0A6A6RC00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">BU16DRAFT_545719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC00"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2502315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="126" mass="13610" checksum="153DFAF662969886" modified="2020-06-17" version="1">MLPLGLLTAAQGHAMLVELKNGETLNGHLVSCDTWMNLTLKEVVQTSSDGDKFFRIAEVYVRGNNIKYMRVSDDIVDIVKEQQAKDQAARAARTGQDQRGGHGGRGDRGRGMGRGGRGRGRGRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCX7</accession>
    <name>A0A6A6RCX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_599591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCX7"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="76"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="37879" checksum="F0520CED6D7BD77E" modified="2020-06-17" version="1">MTAYTCDPLYDYPRDFSGYGEAGLDPKWPNKAKIAVSFVINYEEGGERSVMSGDGMAEQNLRENPAGPPRINERNLNVESEYEYGSRAGFWRMFRMFNEYKMKFTLYAVAQAVEKQPEVARRCVEMGHDVASHAYRWIEYHDFSIEKEKEYIKKGIESLKGLTGYAPRGWYYGRNSPHSRTLVPQVYEEMGEELVWASDTYADDVPYWIDLPTEASKSDEEAKGCLMVPYSYDCNDFKFHVIGSGFADPDGFFAHLKNAFDVLYEEGENGMPKMMTVGLHCRIAGRPGRFGALKQFVEYISKKEGVWVATRTEIAEAFKKEYPYKRGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD26</accession>
    <name>A0A6A6RD26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD26"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="196" mass="21511" checksum="96052DA9441DAD07" modified="2020-06-17" version="1">MNSFTAGESSTRKENENESENPGLPHGTWVSEPPINEVERIGVETHPIERSSTIQRVPNETERSVEVAEDGDGDESGDDEERDPAARRPSFRHSAGEGEEGEERNENELEGEINSISIPPSNAIGAARGGEGLDKPLKTKRVLMGDDNEIRRQMEASARRGDEEAGATVNPDVEDGGREGREGTKKRKCWEMCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD83</accession>
    <name>A0A6A6RD83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_521355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD83"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="110"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2502639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="509" mass="55472" checksum="4B47254D4C25C754" modified="2020-06-17" version="1">MSNIAPSAARQALRVCSRRYPSNSLSRFAHRAAATGCHGRSYVTETKPVNATINVDTTIKAEREAFMKETGSSPAREIMPTTGLSADVMMSPTAGILKQATIMDEGTRPIYLDMQATTPMDPRVVDAMLPYMTGMYGNPHSRTHAYGWEVDKAIEQAREHIAGLIGADPKEIIFTSGATESNNMSIKGLVRFFMRNGKKKHVITCQTEHKCVLDSCRHLQDDGIDVTYLPVQSNGLVDMTQLEAAIRPDTCLVSIMTVNNEIGVVQPIDEIGALCRSKKVFFHTDAAQAVGKIPLDVNKSKIDLMSISGHKIYGPKGIGACYVRRRPRVRLDPIISGGGQERGLRSGTLAPSLAIGFGEAARICKEEMAYDTKRIAALSKRLLSGLLSLEHTSLNGDATRHYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGSSDESAHSSIRFGIGRFTTEAEIDYVLKAVSERVSFLRELSPLWELVQEGVDLNTIEWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDB3</accession>
    <name>A0A6A6RDB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_521420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDB3"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="555" mass="61287" checksum="56849609C1F38F71" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REH8</accession>
    <name>A0A6A6REH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REH8"/>
    <dbReference type="OrthoDB" id="10372044at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="305" mass="33830" checksum="E45FF1F7E4479798" modified="2020-06-17" version="1">MSSSNRRSLFSLPNSPFVENYPDDDAKASTNPPTSPSLLHSTTTSPPIAAAVSSTTQTSTQTFTSAATMPTAAQLFAATMPPQYHEHGTLFTLRGYAYWRKPRSGHSNARCLDASASQFINTDVVKAMIKCERTEHILFATSPSAGRLVTSLELFRNGNRNVNAVTNATQMVDLSAETDRVLRDGDAEVVWSQMLEECRGEWGYQRVTVVEGWEFREFAKKGKDCPIREGWMPLKVKQWDDEDDEDEEEEEDSDGELGTYRFDAGGLEELEGETMVEGGEEEAAEGAEEGGEEEKDEYVVEPIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF98</accession>
    <name>A0A6A6RF98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_612652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="84" mass="9452" checksum="82C26E0C95842BCF" modified="2020-06-17" version="1">MAGGKIPYPKHVWSPAGGWYSQPANWKANTAIMSGVVIGITAIAWSISAEREFRNKMPEQGRFFPSRYWSKQIREHEAAKENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGA4</accession>
    <name>A0A6A6RGA4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_19080</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="KAF2502790.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="74729" checksum="2BF5B12EB8A9CEA6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q8Z6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF14617">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9Z3</accession>
    <name>A0A6A6Q9Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_221418</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2489042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="252"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="501" mass="57208" checksum="E8B3E3EBD8A64523" modified="2020-06-17" version="1">MSDDDDFMQDSDQEEYDFEYEDDDEEQGGDVDIENKYYNAKQMKGDNPEEAVDEFLGVPALEEEKGDWGFKGLKQAIKLEFKLKRYDKAVEHYQELLTYVKSAVTRNYSEKSINNMLDFIEKAAEDADAHRCMEKFYALTLESFQSTNNERLWLKTNIKLAKLWLERKDYRQLADKVRELHKSCQKEDGTDDPSKGTYSLEIYSLEILMYAETRNNKRLKALYQRALKVRSAVPHPKIMGIIRECGGKMHMSEENWKEAQSDFFESFKNYDEAGSLQRIQVLKYLVLTTMLMGSDINPFDSQETKPYKTDPRISAMTDLVDAYQRDDIHSYEKILQNNKDLLADPFIAENIDEVTRNMRTKAVLKLVAPYTRFTLAFISKQLKISLLEVQDIVSFLIVDKKLHGKIDQHNGTVEVESHTDMDRVQAMREWSAAIGSLWATVLNEGEGFKSDESGSQYSSIAGGEGQASQRMSWNPNVAGSKAGKAKGKGLSGRLPGAGSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB80</accession>
    <name>A0A6A6QB80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_575972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004201">
        <property type="protein sequence ID" value="KAF2488727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB80"/>
    <dbReference type="OrthoDB" id="3829627at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="19594" checksum="F191CEEC2FEA1C84" modified="2020-06-17" version="1">MTRHLATLRESYQIPLVRTSSKLVVKRTPDGRSLPRTSTTQGCSPWRPAAVMSTTWRKNYSFKWIFKGRQERTGPHKSAGLYQPLNPSSGQTDFRDRLTRVQLLFTRNLFPLQSSKFSFEYLLLPPRSALEAVQPGVTPKASSRASTPAYSLGYRSHPSGGVWVARLSAIHFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCA4</accession>
    <name>A0A6A6QCA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_531606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCA4"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2489283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="243" mass="27698" checksum="ABD278FB7A180EA4" modified="2020-06-17" version="1">MTALRRPPQPMRLENLRASCLRRPVRRSTLPRALFVRSFAAQRSLKAASPSSSTPSSGRKHVTVVNDDGRVRWGALSKTEKVARTTQQTFNLGIVLLGVVMTGAVFALLYTEVFSLDSKTAHFNRATDQIRRDRRCVELLGDSKHIKAYGEPSWSRWARNRIIASSTEKDRWGTEHLRMHFYVEGPKNQGVVNIHMTKKPSQDEYEYKVLAVDVKGHQRIYLENADAKDTGKSSSKFLGVRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCI2</accession>
    <name>A0A6A6QCI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_447233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCI2"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="221" mass="24925" checksum="D312287DF12A14DB" modified="2020-06-17" version="1" fragment="single">NRKERRAAAKKAGVPFEPTTHEPTISEKSIEMLMAHPDRSGPKGKSLFDLAAERQAEIRAQNPGKYPDEPSNTPEGETPFDDDPIGPFGNALLYSISLCMLHFTLDVIVYSQYREEVVWREITTRTLTNFPVFMIAVWLLHTRTAMRVPWLRNLFFLGTSVGAGCWLVYSGNMNGYYYVMKTAPPIGTMWVWSVVEMDLGYALASVASVVGYVVWNGFEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCU8</accession>
    <name>A0A6A6QCU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BU16DRAFT_531272</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCU8"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="240"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="808"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2489830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="927" mass="102256" checksum="3EB2B87D781F3593" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD70</accession>
    <name>A0A6A6QD70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_531719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="299"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="824"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="866"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1069"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1153"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1287"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1443" mass="159020" checksum="1A20FD90C452215F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD71</accession>
    <name>A0A6A6QD71_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">DnaJ-domain-containing protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="28517" checksum="F8828B01E25F7D2F" modified="2020-06-17" version="1">MLPNPYSVLGVPQDVDEKTIRFAYRRLALKYHPDNARNIDQVAMSCENFKLVLDAYKILIDPEKRTALDHGNPPSAPFISIDTVNTLCSEATAFWDTGIKGMQSCYKWEGEARKSAKAATEEEGTASLSEQLTPSAAFFRCTDAEYNAARERVVGAFCGAVIFASNTIFELEQAQCALREAAHAFDNCADRLNTMLLSLGDHNKWPDRVVNCRNNAKKAREIEAMNHAAEMRWRQTMQAWNTSADAWKVRGQEE</sequence>
</entry>
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    <accession>A0A6A6QD97</accession>
    <name>A0A6A6QD97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_168287</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10410002at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36323" checksum="7E226752188B8858" modified="2020-06-17" version="1">MSDFDKKKSLIVVLKIGSEKLSHLQSPLDGAQIGSAGLSHFPPSPTTEAPSGFVERAHSCDNCHANRINKCDPAGTTTCHPCQLRGIDCTFNPARKLARSCLSCTRAKTACMAGDFTRCLRCLTSGSRCYMRDYQETINTNRSAKRKFLHYDPETGAACDEAPQHGPNASLHMPKRLRFTAPLTATNFDAMEPLFDDDAALLLALDVPEPSPPSTAYVSSSPPGYISPYSPRPKPSQASAPSSRSSSPSPCPLQLISPVLVPAEPPTRPPLSPLGEDEVAPLPPLFTTGYLQEPCPVGAEYYTPGCVYPEPYYMQPAYAWAPYAYPVVWGSFGCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDS4</accession>
    <name>A0A6A6QDS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_566233</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5358429at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="38119" checksum="D7DDDAAE7D14CDC0" modified="2020-06-17" version="1">MNHGKRPREPEGNNVEEIPRLRAPGIEVLHTAFKKVLISFEGHEVRLGVRLAPNGTVEIGFKSNSASTRWIKDETREEAAFLNRLVLRPVSTQRRCFPFMKLPAEIRLMIYELVVNQYPNTVTKDEWFHGSTLRPTIDGTCLPTDISFGPMRKLLVMNKQMRAEVSVMLFRTFQLDFNFDYVNYRYFDEKGRCDLSITRDVLDAIGPLGRANIKKLRIRWWDARWESVQDRSDPAFANVAMEVADLLRQCGKLEQLHVVIPKQKALGKTGLKPRHFSKTCAFGELRAVTNVSNVRIHSPGDALKEWLLEGMTGSKVESDFELWSWWIRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF75</accession>
    <name>A0A6A6QF75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
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    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF75"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17442" checksum="4CBADB93675F52EC" modified="2020-06-17" version="1">MEMKWREDGEEEAHLSGFSSLDTLPAFGRFPPNPHERNSLARLAFLLELSNFPFLHLLGNVYYFESTQSKAQQSPPQRSSLFFPLAHFPFCTTHHSTPHAVFVVVVVDLLFHGLALFYMRIPQGVILFILLCCCFVLFLRVSYPHLSCAVPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFA5</accession>
    <name>A0A6A6QFA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_566195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="690" mass="75026" checksum="616194D9ED7FCC28" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
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    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="352" mass="39584" checksum="39DD653004ECABDD" modified="2020-06-17" version="1">MESHTKFPNCESPASRITQENNEDELVQDSTNLFDSRYVSVHPAGNGFSGDVTFCFLRKALKAVVDSHYKVQLPDYAVDLLKAQLCVVKTLHNPATARTRRSLLKELDVLQRIKASRGKSKERLPYLVDAHISDQPWMVTAAVRGPTLESFLVSLTPGLRIPERLFWHLYIQLSDAFRFLHALKPQAIAHGDIHSCNILLEQANNSLPNVVLVDFGCASIGDLEDYQEDSSGSSTSKSDPQACKLANISPFSYDVLMLAMLLDSLIADVEWICPHARFLIPFPAYLEDLVLYKPAEKLRIESLWAKFGIHATIRRDYLAWDKLKRLQPALDTCPVDDECITRVVEEAGLYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFM2</accession>
    <name>A0A6A6QFM2_9PEZI</name>
    <protein>
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        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd00829">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
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        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
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        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="270"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2490909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="459" mass="49604" checksum="4B8E1C4256E4D202" modified="2020-06-17" version="1">MVKQTAPVYVLGVGMTKFIKPRGKVDYPELGFEAGVKAMLDAHINYDDVDQGVACFCYGDSTSGQRVFYQFGMTGIPIYNVNNNCSTGSTGLYMGKNMIAHGAADCVLVVGFEKMFPGSLQTFFQDRANPTGTSNLIMKETRGVTKAPGAAQLFGNAGREHMEKYGSTIEDFAEIARINHEHSKRNPYSQFQDEYTLDQILKSNMIHEPLTKLQCCPTSDGSAAAVLVSQEFLDARPELKDQAILIAGQCMATDTPDLFNRSAIELIGYSMSELAAKTALAQAKTSPDEIKVCELHDCFSANEMVTIEALGLTPKGKAHELIRKGGITYGPNNKVVINPSGGLISKGHPLGATGLAQCAELVWHMRGWANNRSIKGTKAALQHNLGLGGAVVVTVYKRADGGEATDVSDADIAKKTGLGYNPAVVAKGFTHEQVNTVRSKKARSEWALQDTETKVESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFR1</accession>
    <name>A0A6A6QFR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase ucpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_530531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFR1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="27109" checksum="063DA3C5759DAFE8" modified="2020-06-17" version="1">MASRGRLEGKVAIVTGAGSGFGAAISKSFANEGCKVIVADINREGGEKTVAEKSSHMAFHEMNVTKAADWKATMDAAVAKFGKVDILVNNAGTSYRNKPTMEVTEEEFQRTFDVNVKGVYLGCNAFIPHAIERNEGGVVINIASVGATRPRPGLVWYNASKGAIWNATKGLAAEYGPNQIRVNSICPLVTGTGLFSSFTGMEDTPENRQKFIFNVPMGRIGEVEDVASACLFMASDEAKFITGVNLEVDGGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGE1</accession>
    <name>A0A6A6QGE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_515854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGE1"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="460" mass="51911" checksum="0F3E8C938887B8D8" modified="2020-06-17" version="1">MVTGVETAGLVLGSIPLILAGLEFYGKGIAVSKRYWKYREGIKGLAVELKCESTMCLNSINMLLIGVVKPREMADFLKDPRGTRWKDAKFEKKLKDRLGTTYESYIDTIESMDAAVSKFLQRLKLDGSGKPQFYDHSAFKEHYKRLCFSLKKSDYDDVMQSIRAANLGLYRMTTQTISLGNLNSANAKSYRQTMPKFNVIHDRAQGFYSALSSGWKCPCHADHSVNLRLESRMEDMPSDDESDSDNENMRDPFHVLFRYSHSHSGLSSPPAASPWIWEEAEVRIKLQQTLSPQPQPCPAGGTKGVRFAAQAKKAVKAALDPHPNLQPIQNLCAAISALQKPQRDVCLPFLIEEYAKQKYGILIYPHQDPPMNPESWNDGSIDSGDASVDLRTQWNTADRIVDDLYSEAGDKFSDAVRRCIRCNFDCRASNLHDEAFQKEVFERVVSQLKENFDFLHPSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGM3</accession>
    <name>A0A6A6QGM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGM3"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="424" mass="48203" checksum="CA9128CA3357008F" modified="2020-06-17" version="1">MATTSSSSAPKDASTGLTKLPFPPLTKQHILNCSFHSWHPRYRAITPKARLVPLSPPFLSYLRADGIVLPPDENDRTDWSDSDSGIFSSTDNASEAEDDEDDDPSTQWRDVHEAVRATIEELGGKVVPKLNWSAPKDATWIAATNSMECRTPNDIYLLLKSSDFVTHDLEHAFDDCEEYAPGEEAGSQKEAILSSESIPYHLVLRKHITLNPSVEFRCFVRRRKLITICQRDLNYFEFLFKMQDKLRDRIQEFFQVRLQDSFPDENFTFDVYVPPPHDRVWLVDINPWAQRTDPLLFSWLELLTLPEPSEPSTPEVVSLPLDSQSTYKEDPASAKSAGEDQGDQIDSESEDDEDVEELFAPEFRLVHRDDPEAYGFTTPQYSAHKLPRDVVDASRGGEGSMREFANRWKEVLAKQTEGDGQDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGN0</accession>
    <name>A0A6A6QGN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="46"/>
            <end position="230"/>
        </location>
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        <location>
            <begin position="46"/>
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        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="26011" checksum="819A23D7A2F5B94B" modified="2020-06-17" version="1">MPSSFRTDEEEARRVEGIIAKGNRDLAEIDARHARDMVEMEARHKANRVKFEKESDARKAEMAEERRERAKESIAKRAEIEQDRRDIDALLGRVREDPLESRLGGRSHTQYGSQRRPAPSYTSSQQSTRRQPQRSTSGLPHQSTSRQTQQSTTRQTHQSTHRQPHQSTRTAAPSSVRGLRNEFLNGVGRGTEGSQQTSGNSQRTRETSRRTGNASRRDGGSSGFWDGDDV</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="6">Rho GTPase activation protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_493521</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="183"/>
        </location>
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            <end position="429"/>
        </location>
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            <end position="26"/>
        </location>
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            <end position="766"/>
        </location>
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            <end position="510"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2490877.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="87574" checksum="DC90A0FFC7C96EA3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHN9</accession>
    <name>A0A6A6QHN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
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            <name>heme</name>
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    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <location>
            <position position="462"/>
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        <ligand>
            <name>heme</name>
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        <ligandPart>
            <name>Fe</name>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="549" mass="62375" checksum="34B8E9EF9AFA7B04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHY4</accession>
    <name>A0A6A6QHY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_564496</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHY4"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2492025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="121" mass="13131" checksum="C59B606D3CE5E594" modified="2020-06-17" version="1">MSAIASLVFCTDCGNLLDSNTGVGRTILTCDVCGASCKDTSSKVVVTQSKPTAFPSALRAKRSEVQTLTEADMQTSAAIKETCKKCGRDEVRYYTQQLRGADEGTTVFYTCECGYKWNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIH7</accession>
    <name>A0A6A6QIH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_128447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIH7"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025399715" description="Peptidase M43 pregnancy-associated plasma-A domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2491780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="295" mass="31226" checksum="4278332E642C7787" modified="2020-06-17" version="1">MIFQPLLLASLALAAAATEYKHFDCGTDVDAATKEFMSTLNDLHTDEKAGSPAARAAHLARDDANTPIKVDAVFHIIATSDKKDDITSDMPQKQLDALNTAYAPYKIAFNLLNITWTVNDAWAVGAGADDLAMKKGLRQGKYSTLNLYFQTDLAGSVLGKCTLPSSIGPGTPAPSVYANDGCSVQAGTMPGGDVDGYDQGMTAVHETGHWLGLLHVFEGNSCAGTGDFIDDTPVQSTSTDGCPTGSPGKDSCPTQPGMDSVHNIMDYSTDACYTGFTVGQVARMRSMWGMYRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIP2</accession>
    <name>A0A6A6QIP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_620924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2492429.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="117" mass="13428" checksum="FFA25FFDB6EC74D5" modified="2020-06-17" version="1">MPPRADFSFSRARRHQVQPQPTPPQQFVDPQEDSDLTQDEDEDDELVEGADGEEEEEEEEEEPLGKQHASPLKCDISSTSLFSARAIFLSYVDLYSYRSYHILFSTRKTYPSPLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK88</accession>
    <name>A0A6A6QK88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_515473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK88"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="359"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="879"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="909" mass="100548" checksum="F292902949C66023" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKD7</accession>
    <name>A0A6A6QKD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_514017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKD7"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="248" mass="27290" checksum="C16C7846EBF20ACE" modified="2020-06-17" version="1">MGKITTILFDCDNTLVLSEELAFEACAELANEILESKGETDRYTGPSLLKDFVGQNFRGMMTSLCKKYNFTLTDSEFDAYVDRELGKVIETLEKKAQPCPGVVSELDALFAKKHYLLAVVSSSALSRVVASIKKTGLDKYFKDNHVYSAATSLPKPTSKPDPAIYIHACKDLGVTTAECVAVEDSRSGATAAKRAEIPLIGYVGPYEAEEQQTMYDMLKNECGAIYVMRHWEEFPKALEAVEAAVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKI2</accession>
    <name>A0A6A6QKI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_491642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKI2"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000860">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
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        <property type="protein sequence ID" value="KAF2494416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQI2"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_H"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="93"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="269" mass="29823" checksum="0720E7F82B4EC3CA" modified="2020-06-17" version="1">MNVHTLNERGDGVDSTEHPLIIGYNAALQDIPGLNTAPRAPPLSGIPLTTAEVFRPSAEADTPITLFTHHASEHTIRYCHPGAHRLVRRFVTDPREILIYTSGSCFDQRDATESPKLIAGCAFVYKPPPYPKTSCQFRLENRGPTEVHPLTKRRAELRAALGALAFRKWSGEGWLKVVIATDSNYVVFGATEKIEDWAEEGWKTEADSPVEDVDLWKMLLAEINTLAGNGVEVAFWRIPRELNLADSPAKEAEMGEERTEYSMVIGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQJ2</accession>
    <name>A0A6A6QQJ2_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_45244</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQJ2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="17529" checksum="E5204D9AE5EE647A" modified="2020-06-17" version="1">MRDSRLWNSRRVHPLLPRIIRHHIIGLINSYSRPASVPLLTVLVEYSNGWSQGKELGTPEVQRRSQAAVEHTTFAMHASGETLLGSSFSNSKVTLFLSGTRSAEGDCATVIRMAPQPSLGIHLEYSDKLARMVTSKPELYYSVQNLARITVSLRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQL8</accession>
    <name>A0A6A6QQL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_583242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQL8"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
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    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="598"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="555"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="93051" checksum="04F6A2980AF26687" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRM6</accession>
    <name>A0A6A6QRM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_461405</name>
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    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRM6"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="25217" checksum="12A1E2F6078C88D6" modified="2020-06-17" version="1">MRSPQSAIRDDLAQLPEIKKWGWVIYRCTYGDNATWAKFRDRVEAHSRKRIAQSDAPNIAERLEWTWVEDSSALDGASTAALRERFRAWVADEVARQPGNYQPTVIPRFRYFIKIDQEVLGSLAESNFRETHWSDDAFVKFVDGNWEPLAESQQDGEQEDDGWEKEVLEPIEGCTEEDVGWMRIAPHMINADFYDVLSGDENQWITFYERPPSIVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRY4</accession>
    <name>A0A6A6QRY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_462679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRY4"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="477" mass="52734" checksum="DB9BBCD119A65F9C" modified="2020-06-17" version="1">MSHHHHHSDRYEQEQIDKDEALAARLQAEESQRGPSNYPGQGRQGGGYQSQDYQGEYHGNPPQGYQGGPPQSQYHSRPQHGYQGGYQEGPPQGYQGGPPQSQYQSQPQQSYQGGPPQGYQGGPQHGPQPEYQGASQYQGQTHYQGGPPPTAQHPYAQTPQPLHRKSLLIGINYVGSKHALRGCHQDVTNMAQFLGQKGYSSDQRSQVIMRDDPNTDPRGPLFPTGKNMLAAMHWLISEPNTCNFLHYSGHGSQVKDPDGDRESGFDDTIVPVDFEQNGQLDSDKLHRTLVSALPANSTLFVIFDCCHSGSAIELPFVYRSDADGNVSMIDNVKTGMVLLQEASSLISGGFSMAKVVKAKELFAGANTFFKQLKHSGEQQEEGVGEENFVEDWKSEHKFVTMFSGCRDDQTSADASIQGSSVGAMSWAFLETMKRNPNPTYLNSLQQTRTVLGESHYKQVPQLSIGFKELDLDQPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS22</accession>
    <name>A0A6A6QS22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_462319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS22"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="528" mass="59677" checksum="02B41CC2B0788F42" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS70</accession>
    <name>A0A6A6QS70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_550170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS70"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="638" mass="71069" checksum="954ED28A5CAC9656" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSR7</accession>
    <name>A0A6A6QSR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_527084</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSR7"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2495209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="37133" checksum="B625C7FAEAC14DF6" modified="2020-06-17" version="1">MGLETPIQHDATPNGINKPESKTARPSMDPNVHNAVLGSLLIKPWYPSFYPEELVGREVERLYVCQWCFKYSKDLINEFLGHLKVCAFKDTPPPGAVIYTKDGYSLHEIDGEENKLYCQNLSLFAKLFLDTKSVFYDVTTFLYYLLVAHDPTPPVPVTIPGHSNSMNGQVVGFFSKEKMSWDNNNLACILVFPPWQQKGLGQILMGASYELSKREGRLGGPEKPLSELGKRGYQSYWSHTIARTLLSAPQKKTLTVTDIRDQTYIVQEDIIATLQAMQVLDHKKRGGAENVINKAKVRAWAAENKVDLNPPVDAEGFVEMEEDEYGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSV3</accession>
    <name>A0A6A6QSV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_394138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSV3"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="421" mass="47957" checksum="5F93B01649A9139F" modified="2020-06-17" version="1">MAAPGGEFFIQKNFKKTAAHHESFKQLWETKWKAPASMGVYPFMFGTTKDFQPIVDELVKQDFKEPYDWDAYAQVYFPKAEELTKIAQEAEKAGEIEKASEYYLRSSAVYRISRFPAPRSEKQKYAWKMGKEMCIKGLGLRPHPVHEVMVPHKHAIEGEGAHIPIYHLLPDTATAEAPAPLLIIMTGLDGYRTELSVWMEGWRQKGVGTIVLEIPGTGDSPALPGDPKSPDRQYESLLDWIDTQDRIDKKKVCVWAFSTGGYYAIRLAHMQPHRLAGVVSQGGGVHHMFDPAWLEQVNHLEYPFDLANTLAYKYGYGNDIEKFKKEASDKFSLLKDGTLDKPECARLLLVNGTEDEIFPIDDYYLALQHGAPKEARFVPDKKHMGEPDAFFIILKWLYAIFDVADKNPISQMKTMPFQPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU31</accession>
    <name>A0A6A6QU31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_560868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU31"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="467" mass="52667" checksum="FACA947D0C3083E1" modified="2020-06-17" version="1">MVHPRELDIVVYGDHRRVYRPGDKVEGVVFFFPTTQQHIKSLALDFSGRCITKTTRPQYVRPSDGRPPILEGLKRLEAEATLFRFEQNLLVDSTITAKKHSWPFEFTFPSHTRDRYPKWADSSKFPKDVHQLPPSYHVYMDEPGREATITYAVTANVSYGRRQHKSDKATLHELKFFNDSNLRSHFIAPTPMPHVLKEQRWTSPALRPAKHTLKQKLEHVVTQNPNLRTPSISIVPTIYCPPSISPRQDIPLKVSLQHIRRRPAVDPEHIDCIFQSLNVSITTYNRTVCEGGIQDVTEQRRNCVTRRDINTSIPLDDSPFSIVSNLRLDDNAQCIASFATFTASRSYRLVIEMAVKCGPRTFIINSSTPLEILPSPSLSRPAAVAQPRESFEQLPAYEPRPALPSYTESTGSVATLGSLASSDDDSGSEEEDSLDDGVSTPLSPPITPDVDENDRGEWIREDKTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUB4</accession>
    <name>A0A6A6QUB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUB4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="215" mass="24389" checksum="A2F677B3233786CA" modified="2020-06-17" version="1">MPILASLTHPTDPRWHGVLRHGPRILISITLFTLFLWVITIAQMGWLATANNRYAKCWAAHHTPKTHFCTMDFPPRIWSRGHGDPASDFFFWCLGMVLVFEAIHLPLSLVLLVRHSLHPVATLVLSLIALGMWTWQVTFEMFGAWGIEWRIVAAFEGLLWTSVAAGWLVVGCYIAYVVFACMAVHRWRVGGKGRANRVPGKRLNEESELVDFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUG1</accession>
    <name>A0A6A6QUG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_560885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUG1"/>
    <dbReference type="OrthoDB" id="3941746at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="378" mass="42230" checksum="89EF53B0B7570105" modified="2020-06-17" version="1">MEMVEMTALPQGGSTGSAAASGVRNVNDKIQNTALPSPGLQHGDATSSPAQAPHDTNVNNSPLGSANQQRVLSTLPRTCEGDDHRNGETKIQFDAPDPLQNPPGFIPEEQSPFPFGHRMLYQKEPSCARNQLVYAHNYFFGPHYFSSYQEVRQITPSQYVTPNPNGYHRVRRLKVGKKCIQRIKEIDSIGYYIIVGIMNERTGIPREELGWVHGTGDLFKTIHGLARRLRNLPRRLLSLKRVAGFKVYACHPDAGYHENVEMDHKTEMILQSFYHDYNLKSAKKDYEDRWAKWVHKSFNSCSLDPGDGKLALQLVLRWSPLKITAYVSTPVILSLAIGIWYMKHTGDIQTAWTISSYIVTAAGVLIALLAAVTSLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUP8</accession>
    <name>A0A6A6QUP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_360268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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</entry>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
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    </reference>
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    <dbReference type="AlphaFoldDB" id="A0A6A6QW85"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="448" mass="51795" checksum="12BABC6FB147C399" modified="2020-06-17" version="1" fragment="single">MGLERMQDKMEQWLQAPDPSTNYNKALQQRHEGSGSWLLESSNFAKWKTQRNSFLWLFGIPGCGKTILSSTVIRHIEEVKSSKSLLYFYFDFNDTNKQTLGNMVRSFISQLYYKWEDTRTQLESLFAACSDGRDQPTCEKLCKTLLDMLQLVDEVWIVLDALDECSTRSGNPTEGLLSWITGLRNPEHGNVHLIVTSRLEEDIKSEICEWVHKDNLMPLRGDSITADIRAYVRTRIREDKGLKRWRSRPEVQNDMETRLMEKADGMFRWAACQVDALVECLDYDDLQDALESLPDTLDETYARILKAIPPRHKPKAIRILQFLSFSERPLRIKELVDAIAVHPKAEPHFDCKWRMPNPQEIARYCSSLVAVVTTKARRKNEDDEDEKDRENLELRLAHFSVKDYLTSTRVQGNFAQAFQEAAARSSIATVCVAYLLDMDQTLSMHELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWJ6</accession>
    <name>A0A6A6QWJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_336344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWJ6"/>
    <dbReference type="OrthoDB" id="3946002at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="444" mass="51944" checksum="F73F9E7D2F8F8431" modified="2020-06-17" version="1">MAGSRNSQIDQWRPEESSIRDRDRERPLQRRDSRERELVGRRGRDDHDRNTKRHHDSDHPSSSKHHRQHSRDRSLSRTRPRRHSRARDSPSPRGNRDDRYRPTRGRLPSEERPSHSHKHHRHQSPPSAKRRRSITPSPPRDSTKRTKRYRSRSGERSPSRSRHPDSSRRATDRAYSPRPPRSDRGIERRSSPDTYKPSSIRRRSRSVDSRYRPPPPKPRKRSPSPDRRPARRDLSPRRYSPRRHHTSKRRSPSVEDRGRAHKGSERDTHRGRENSARPSRSFARSRSPRYRRSLSPPRAKNRLSPPPRRDRERSPRAYPSRVSPHRRRNRTRSPPRTRPPARSDKDREPAKPVRANNNISRRGSPRPASVHNADTQKSSDRDAKMRDPYQAQGRPPRPPADAGSNYSHSPPYMTPTHISPPQGQSPYNARGGWGGQQHYGSQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX00</accession>
    <name>A0A6A6QX00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_458009</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX00"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="58"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="295"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2496951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="570" mass="64105" checksum="2A94EB1C87EE2FD5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX67</accession>
    <name>A0A6A6QX67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="TRI12"/>
        <property type="match status" value="2"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="42"/>
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            <begin position="1"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Culley D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="248" mass="28174" checksum="0FC1566355F36EAC" modified="2020-06-17" version="1">MASAPAAALLLGISGPSSSGKTTLSRLLRDILPQSFILHLDDFYLEERNIPIREGVQDWDCIESLDLNGFREALSHIKKHGSSPPTLVSKEDQNAVGEHRVPAELIEELKQRVQALVAEKSWNMPIAIIDGFLLFSNEMADIRDLFDVRLFLRTSYRTAKTRREARTGYVTLEGFWEDPPGYVDQIVWPNYVKDHSFLFQQGDVEGELDEDVCKRAGIHGMPREAEASMEQCLEWALQKIEDAMSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZJ2</accession>
    <name>A0A6A6QZJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_537500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZJ2"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025706556" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="15">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2497908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="642" mass="69526" checksum="6A31E86ED186BCE7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZL6</accession>
    <name>A0A6A6QZL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_525745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZL6"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="306" mass="35004" checksum="8CC1686BA0310975" modified="2020-06-17" version="1">MATRKRNEWLDAEESDDDEQGYDSAEESKTKALPGRATKRRKVDDDSNEEDVSDHADEAEDQDQIASRVEEDKEDIMPTEKPTKSKSKTLKTLSQKKLRAAEKARASTGVIYLSRVPPFMKPSTVKHLLSQYGEIGRIFLAPEDPASHTRRVKAGGNKKRSFTEGWVEFIDKKDAKLVAETLNAQIIGGKKGGWYHDDLWNIKYLKNFKWDKLTEQINNENAERAARLRAEISKTTRENKMFLENVERAKMLDGIAAKRKKKADDHDTEDRGFVTSAHNRREFRQIKVKSKSSTDQGEAIVPLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZP8</accession>
    <name>A0A6A6QZP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_318309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZP8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="10293" checksum="BD52E48EB9A5C25D" modified="2020-06-17" version="1">MHMSCRPSKIDLSRQHPSLPKRLISLNCRCAPSCSSPSLFPCATPLRRRCLFHQTCLLLRLPFGFLSAFFLCRLCWTSVLLQPSIDMVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZT0</accession>
    <name>A0A6A6QZT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_506102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZT0"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="320" mass="34747" checksum="24FC708AE5029369" modified="2020-06-17" version="1">MASLAAPRSAVRYLSRAVPSVTSRRSSKLATAASTRCLHQISTAPSITSSSTRHRPTTQRWATSSYTPAAASGRRTMFIQTEETPNPDALKFNPNSRVLPESISSAFLEYLSPRSTLAPPHPSPLAAQLLNVDGVTSVFLATDYITVSKDSATPWAHVKPEVFSLINEFMLSGQQIVNTVEDRAGESGQGGTEVDSLAYDENDSEVVGMIKELLETRIRPAIQEDGGDIEFRGFHDGQVLLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVQGVQQVLDQEEEIAMAEFAKFEEKLRQQKGPDAAPSTVGKGSLDTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0F7</accession>
    <name>A0A6A6R0F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_548624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0F7"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30494" checksum="42A1857A5AFBCBC0" modified="2020-06-17" version="1">MAAFLKLLQTFLYAVEFCCAGIILGIYSYFLSVLADRNLGIPTWEKAVEGLSGAAVLYLIFAVLLTCFLGGKTFFAFIAILLDILFCGAFVAIAVLTRHGAGSCSGNVKTPLGNGQSKSKNGFGANGFGDKHDDSSNVTYSVSLGTACRLNTACFAVAILGALLFLISALVQVFLARKHKKDKRYGPGPSNNYTSGSGGRRKFWQRKPKNTVARDSELGTVGAGVPAGLMADKHDVRPSHETGYTGSTVAPAGPYENSHKVGGYHTAPTGGAVNPYGYDNTHATPATNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0W0</accession>
    <name>A0A6A6R0W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_293458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0W0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2498408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="380" mass="41411" checksum="266FA25B95EC8721" modified="2020-06-17" version="1">MAMAVDNRQQSQLNTMGYDHLRYPAPHFTNPWVSGPAAPSSQMYPASGLEKFEGASQQHVQRPTSLSLPFHNLPVTAPPLGSGISLSDGTFGSQNLLDASQDLLNPSRTYPSGYSSASPNAASYAPTSAPQYPMDYSNNSRSPYAYQQDPARRSSHPSVSSADLLENPVESQRQRQSSLVDFNRINSQQAQRNSFSDALDASRGMVAMSQDITPRNIYGNQGGSRSSSDSYGFPSTHSAHSSISSASTYPSYYNGSVAESSVTDYSSASESVEPMTSRTLPRPSALIGTNLPPAPQSMMGQFSSKVSSSSQKKHKCKICDKRFTRPSSLQTHMYSHTGEKPFACEVEGCGRHFSVVSNLRRHRKVHKGERDHDHPSPEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R258</accession>
    <name>A0A6A6R258_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_299861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R258"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="445" mass="48279" checksum="AB811E70F066A97F" modified="2020-06-17" version="1">MSTTTSAPAPSNTGGGNNSSGPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRAARAAADGEPIDLSAMTRPHRRRREKKLMSMEEVNERFPLTKYKAWRYSRENQGLPAAGGIATAPSRPASVKNVDSANEPSGESRRSTESTRPTTALEIAREDLTAPTTSSPPVPSPNVEPVVAESASAQEVKAKEEEKVPTEKSGDVTEVKTIDSTTPEESSDNPKHDDADDSDDDDPIRTATAPELLAEPGDTCAICLDTLEDDDDVRGLTCGHAFHASCVDPWLTSRRACCPLCKHDYYVPKPKPEGETPEVTTGTRMAGLRLPTSPASTWMGNRGQFSRSRVVFIASNRDHQAAPTGGLMNMHNHRPTRPNRGADAATPTRPQATQNPSWRTRLHAMRNANRPSMPNPFARNRNNATTEPANEVAAPTEIQPTPAQLEAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2P4</accession>
    <name>A0A6A6R2P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2P4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="142" mass="15668" checksum="C35B0FF2CBD9C0E2" modified="2020-06-17" version="1">MPILESIDVDTLEVNPGYEYSKEDIEFFQQYSDEVLSLDQGSLASEEPEPAIATLKPTETLSLEPIINEAQREDEVVECLHPETDEVIGPSQRSTALAEPEAAISIAGPAEIPGLESDVTEGQSEDEVVDFLYPESDENVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2T1</accession>
    <name>A0A6A6R2T1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_548435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2T1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20654" checksum="2BDD9A9BF17C4F4D" modified="2020-06-17" version="1">MSEGGGSIFGPLSLSSLITRIAELSEAINSMFEWYRRSKVCYAYLEGISAEDVDHCGVPEDCHLIQGQESVFSDSKFAQHRWFRRGWTLQELIAPSRVELYGEDWAYLGSSLKLLDEIVFITGIDEKVLNSNQKQKMEFLRRASVAQRMSWAASRMVTRPEDQAYCLLGIFGVHMPLLYGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3C3</accession>
    <name>A0A6A6R3C3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_558346</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3C3"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="68"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2498273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="175" mass="18937" checksum="335D503AF8583929" modified="2020-06-17" version="1">MSTIAHEVSATQTLETDALIHGLSTVEIRALTTKCLEAREMAYCPYSLFRVGAAILLKTSSTIISGANVENASYPVGTCAERVAMATAVIQGHRLGSFKAVAVATDMDAFCSPCGMCRQFLREFCELDMPIFMHNASGAYEVKTMGELLPLSFGPDALPPREVLEARREEKPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3D9</accession>
    <name>A0A6A6R3D9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_523750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3D9"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2499245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="81" mass="9317" checksum="F3CC9EF5445A7477" modified="2020-06-17" version="1">MPSEISDLKQFIEICRRKDAKSARIKKNKKSNQVKFKVRCSRYLYTHVVKDAGRAEKLKQSFPPGLLVTEVAKKNPKGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3V0</accession>
    <name>A0A6A6R3V0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese and iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_479743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3V0"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="341" mass="37811" checksum="16945EE6150C4A0C" modified="2020-06-17" version="1">MIIQPTLRLPRHLFRSADRAARCFSQSAPARAHKMPELNHDKDMRRDGIRGLYSPDGIAIAWVEYHGMLLNKLNFMTAGGEEENWEPKKLLIHYARDPTNAAIFNLASMAWNNHFFFKGIFRAPSPKKKDDPPPTPPPMPTTLATTLASEFGSIQTLRDEFLATANSMFGPGFVWLVKTKTGYNSSFRILPTYMAGSPLAGAHYRRQPVDMNTQNGDSAASLGLSRAELGKMGVPTNSVGAFGAQSASYAKQPKLAYGGVDVTPLLCVSTWEHSWLRDWRVGGVVDPNDPDGVVGPTGKENFLAAWWDRIDWKVVYDLMQDSATSRQGSTNNDRAFAFNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R400</accession>
    <name>A0A6A6R400_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_265952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R400"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="346" mass="39797" checksum="6E405BD1C1E0D301" modified="2020-06-17" version="1">MFGPFELFNVFRYCGLGHLSLPGQQFRSRLQLRRWRCCVRDNVSQIVYIQLHIPERAPLQWIQERRIPVRWPNDEQQSDQNDIMHHIFNLTLDGELFLAPIGKHPQRVLDVGTGTGIWAIEFADRFPSASVIGTDLSPIQPSMVPPNLQFEIDDCCEEWLYTKESFDFIHIRLLNGAVANWSSLYAEAFAHVKPGGWIECVEGNPITSDDDTISPDSVYHQWNQVTFDGGKAYGKPIIRSSDEVKDALSGAGFVDITERRFKWPIGGWCKDQRLKEIGIWNRLNFEQGMEGWCWYLCTAVLGWKTEKVQMMLAEMRLMLRQKGVHAYNEVTFIYGRKPPAKVSADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4K1</accession>
    <name>A0A6A6R4K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_578841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4K1"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="374" mass="40755" checksum="A44CF20C88E9AE60" modified="2020-06-17" version="1">MRYIRFLKPPRLQGTTLSALITITSDLGDSFLAEDVILVASLCSADADGEIALRKVLKWTSGMRSLPVAFDTGHTDIEWPAQLHVSLKGSPESDHFEVHYSLNADLPSLVSAWSGIIDPPSGLYIAEKKVERRFMPLNNRTLSIWEETGESIARHLWDAGIALSAYLDRVVSLQANGLDILERVLSSATYKKLRVLELGTGCGIVGIGLAQSVPDCEVLLTDLAEAEEIVARNIEIMKPAMSSSVSFTTLDWDEPLPRDVQSKALDLIIVADCTYNADSSPSLVRTLSALVNRSPRAIVLVAMKVRHSSEAVFFELMTDAGFAIGCQTALQVPGDEEKPTETVDVGLDAIYCAVSGARRLTIDYLADDSQRYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4M0</accession>
    <name>A0A6A6R4M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_557983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4M0"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="187" mass="21167" checksum="7823984D0EBAB088" modified="2020-06-17" version="1">MSLPTLFPRPHFRPPSTALHLKPTSLPSFQAPLSDLFTGDWFILRSSNPFWKDKRNVRLHYNPAPSGSHIEDTACYQTMISDTVKIVVGKDTPVDGETGTYTWQGKGLLRVARGRWEILSFTARDGGDWMLVFAHKTLFSASAINLLCRRKEGLSKEDLGEVEEWLNGVEDEKFQQAARGVFDIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4R9</accession>
    <name>A0A6A6R4R9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_570435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4R9"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025654001" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="426"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="541" mass="57297" checksum="7126785EA814CB0D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5A8</accession>
    <name>A0A6A6R5A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_535980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5A8"/>
    <dbReference type="OrthoDB" id="10445120at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="151" mass="18203" checksum="B8677D25EE2A1115" modified="2020-06-17" version="1">MSKHRFTEKTLELEEFVPKRWFFEIYEDKDPEEICARIRYVTDRAIERIDLGGRQRNFRTEVGWNKENEDPGTGRFRRHFLNLLIRHRFERRRQCGKRIRKANHTPLHHHFPSKTPSCYTPGLIREGAGKWVRHIEGIHGYTHNVLSQVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5J5</accession>
    <name>A0A6A6R5J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="9">DMRL synthase</shortName>
            <ecNumber evidence="4 9">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_282087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 9"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5J5"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000007">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499746.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="19129" checksum="47B0F5E7F8570DA4" modified="2020-06-17" version="1">MATLKGPGAPKSYDGSGLRVGIVHARWNNKIIDALLSGAKKSLADAGVKKENIVIQSVPGSYELPFAVQRIDLPSLTKEPATKGSTAPFDAIIAIGVLIKGETMHFEYIADATTQGLMRVQLDSGVPVIFGLLTVLDEEQGLARAGIAGVGGNVGHNHGSDWGSAAVELGVKRKGWAEGKMID</sequence>
</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Alfaro M."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24883">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="186"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="475"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="705" mass="80354" checksum="604D39BE335E7FBE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6P6</accession>
    <name>A0A6A6R6P6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_237126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0050684">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
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            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
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            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2500136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="626" mass="68896" checksum="60A7637A2C5D64A7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6T2</accession>
    <name>A0A6A6R6T2_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_601702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10382691at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="38488" checksum="432B87DC386E0A2C" modified="2020-06-17" version="1">MSDFYPPLPPGALSTQSHRTSQTAVFRHRGREYITVSDDEVPRDVGRGLCIRCWEPGHDDFYACQGRCAWCKDKIKHDNVACPLCIKGSIWWRNRIGFEPRGFDDTYGGRHRGLNDESYKRKLDMAAMLLEDARAPTSRKRRTPSSASKTASASEEKTLFAYSDWPDEEEVEEEDEASLNTRETSTDSLDHPVHYQRSKSPPIAPSNAIIAPKRRVVPRRSTDSYRPPKRPHHHQTSARTHDYDEAARHRRELEDLEDRAEVLKAKLKEGIRAADAPLAREERRVPLKEEEDAEGRTMGQLLAENRELREQVAKQQRLIAVLRAEREAREDLLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R742</accession>
    <name>A0A6A6R742_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R742"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="35793" checksum="E2FF752EC3D3DC37" modified="2020-06-17" version="1">MKEKIKIDKGEFRFGSLITIHDHTSWTWKHWGCVTPLQIGHWKEAVEGDLELVDGYDELEEEYQAKVRRAFEQGHVDDEDWKGDVEVNRPGQKGFRVKKLKEKAPKKSKKSKKDDADEDDEAEAESPAKPKKRGRPAKTAKTEEDSDDEAPPPKKSRGKAKKVKDEAAGDEAAPAAKKGRASKKAVKDEVMDESEEEAAPVAKKGRGSKKAVKAEVKDESEEEAAPAAKKGRASKAKAAVKDEEVDEEATVEDAPKPKKSRASKKTKAEPIESDEIMEDVEEAEPPAKAKRGRKKKGEEAGAAEEKAVPQKRAKKASRKAPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7G9</accession>
    <name>A0A6A6R7G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_524148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7G9"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2499693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="178" mass="19927" checksum="B298E49EA9D7A439" modified="2020-06-17" version="1">MSDSPLLFSPELISPTVLAALPEGYTCRPLTRTDYANGFLDVLRVLTQVGDISEAQWDERYSWIEKRADSYFILAIVDEKKRVVGTGALVAERKFIHNLGMVGHIEDIAVAKDQQGKKLGLRIIQALNFVAEKVGCYKTILDCSEANEGFYVKCGFKRAGLEMAHYYEPPKPNVLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7H8</accession>
    <name>A0A6A6R7H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7H8"/>
    <dbReference type="OrthoDB" id="5558646at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025499044" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="246" mass="25489" checksum="F1ED17936FCF197B" modified="2020-06-17" version="1">MKLTITALLSLPLLATAHTIAQRVSVNGNDFGQLVGIRSPDSDNPIQDVNSGNMACNTGFHSPVSSKVIDVPVGAKVGVMWGHVIGGAQSAGDPDNPIAKSHKGPVIFYMAKVDNAASSGTSGLKWFKVSQDGLDSSGQWGVDRMISNSGWTYFTMPSCLASGNYLLRAEIIALHSASTQGQAQFYMECAQINVTGGGSANPSTVSFPGTYSATDPGILINIYDNSGNPTGGGKPYTVPGPAAFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA95</accession>
    <name>A0A6A6RA95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pyrimidine monooxygenase ruta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_500979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA95"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01699">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019914">
        <property type="entry name" value="Pyrimidine_monooxygenase_RutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03612">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="368" mass="40562" checksum="D4BE82EA64E51C7D" modified="2020-06-17" version="1">MAPNLDIGIFIPIGNDGWLISTTAPRYMPSFELNKQVVQKAESYGFDFALSMIKLRGFGGVTEHWDHNLESFTLMAGIAAVTKKIKIFASTAILTLPPAICARMAVTIDSIAPERFGVNIVTGWQAAEYEQMGVWPGNKYFGYRYDYAQEYVQVMKDLWGSGVSNFKGTHFTMEDCKLSPKPTGKIPIIAAGQSDRGTKFASEFADYNFTSGKGINTPTAFKETHLRLIEAAKSTGRDVGGLVLMMCIPDETDEKAWAKWNLYREGTDYDALAWVTGQTSQDKQKDARATASRLTASDPNGDLVNMNGGTLVGSYESIARMLDEIAEVEYVKGVMLTFDDFLVGIDQFGKYIQPLMKSRSKVNGVNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAE4</accession>
    <name>A0A6A6RAE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_614441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAE4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="20148" checksum="E26C39A8785A3467" modified="2020-06-17" version="1">MGNSSSARCEEHPPPYNAILAENSTRVEVQEQPRSTAIQATSSGNVTSMNLTISSSHPEPFIQIFRLTYCNINTTTEKYGNIVPTSCNLCIQQGSTGHITNANTCNINVHTYSASDIFNPVSCNIYIWNDANGTIDNPRSCNIYFQGSSKNFTISNPKGGALFFGENHFTNKRTCKFCCQPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB81</accession>
    <name>A0A6A6RB81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RB81"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="473" mass="53424" checksum="0CB994096C5BB5DB" modified="2020-06-17" version="1">MPTKSVDPEFEAMMNRAAMALQNLPIMSGSHLSPIRSVPVTQNQTLPPSVSSDRQAATTSAFVSDDIDTLSGSQTEDLTKRSPLITFLTESDRYVPMFDVITRCLPVSDLLNLKRVSKELQDVYAKAQKSQWNEARAFGNFFKDPTGFRNKLGEVAGLISGIFVLRFLARAGNGNMLDLYATYGPQADALEKYLLDVEGYYVSDEETAPVPSNLNVSRSRKAQTFRSSRDKRLFIYLNHTNSSPMLDILRGDVYSTAATSIMTATKVYSPFANMTFKSDKAYIIRALDQNAQTHLKDIEHARREILDLRFKDRGIAKYRRLNDGDCWVMSLDTCNIATPAVPDYVYDHTDFLFTDSNHRLSPPENIGSSLHYNCLLGPLLHPGLKHTWLGCVEADNRKDAIMRRLDAVVWAQLWKLRGRDRPVNWDEMLRTPLLVREMTGYTGKTFDEKLPEWIKELDDLSPVKTDGPSTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBF8</accession>
    <name>A0A6A6RBF8_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
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        <name evidence="7" type="ORF">BU16DRAFT_555580</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <property type="project" value="UniProtKB-KW"/>
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            <begin position="8"/>
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            <begin position="521"/>
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        </location>
    </feature>
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        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="677" mass="73280" checksum="08F61ECA4C0378BD" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A6RC61</accession>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="98" mass="10592" checksum="04A3D5F15D901071" modified="2020-06-17" version="1" fragment="single">IMHRRPSPLPDADPTCTISIRKRPSFETNCTFFAETKTRTQYTDCGGCALTTKYYGLGLPCRVSTTVEGVAHVTETACDAAGPTEQSSLAFFTPTPTP</sequence>
</entry>
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    <accession>A0A6A6RCA6</accession>
    <name>A0A6A6RCA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
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        <lineage>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="17416" checksum="E2803FCB72C8048F" modified="2020-06-17" version="1">MLELTLLQNTKTNPWDSLTPPPKHRRTRCRRGRHILVPRRSFYPHMPNLSPKDLEDRERGRVDHSEGQGSRRHLRPEQGYHPRRLPMPLQSDITSAVAGAHYITVWDGAFFFYQWNVTRSDYQKLVVVSHRGQEQVKVAVQGYRRNPP</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502738.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="16453" checksum="9E23EB6058089FCE" modified="2020-06-17" version="1">MGRARLRPAHLHPQCLRDKTSLDVGKQDSTSIKPPSVQSKLPLAPADPALETLTERAGVRPPHLIFLTTPGFAPMSQHPYHSNRIAPQLAASAIPPRSAHSRRPLFEDEDEDEDEDEDEDEDEDENEETHYGDLPHGNMRPPSSAQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD53</accession>
    <name>A0A6A6RD53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_7191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2502394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="504" mass="54251" checksum="844F383E5E74200D" modified="2020-06-17" version="1">METLDAGSRQSVGLPSINYLESDKIKRDEPGFQRKHSAAAMASPSYPFPGPPPPYSNHQSTGASSTGALSGLISPPESRRTSSENEKEQRQSARQSLPSIHEALGDGQPLSYPAPPPSAPVSAPQHYQPSPATSGADVRPRTYSSDLQSQGPSNPYAHPRSPYTTPAPPSTSGPPPPPPPQVESLPRPPFSSSSHNPKLPTLHPLRTQSPPINASRPSVPYSPYSQQAPPSTYEPAPSSAGPMNPPYGGYNQYSQHYGPYSAPTPGAPGPVYPPGAPYSAQARYPPPSWRNDDMSRVEENKRAGRTGPPPYGDSVKRHLDTFDFEASLNEMLDGGNRVMHFTKHYMDRSHENQRSGIQPGSIPGLNEVDELMKHTQRIQDSLGRIRDVVVSQQTALAEQARDPYKPMNGYDHEPNPYHEDSKGGGGFAGSDLKKRRGRAAPPGRCHSCNRAETPEWRRGPDGARTLCNACGLHYAKLTRKMGGKATVGSSNLRPKSLGPGSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD75</accession>
    <name>A0A6A6RD75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apses-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_521348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD75"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000291">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="482"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2502629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="669" mass="75702" checksum="9ECDE68222EA49E3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD86</accession>
    <name>A0A6A6RD86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7165 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="497" mass="54579" checksum="F1381792A8BD147E" modified="2020-06-17" version="1">MTIVATALRQVDGPSPVPVNKPARRKWKAKTLSKNTPTSVPAAPAPAPAPMEGPKAAESAPMPSQPAKATDSRPEPTKQADAPHRSKPTARDEVVLSPPEFTRLKTGQKVSIVVGDPGNQYIAIEAAYAKVLSHYSQYMKQVLATDHSPRLIIPRGDKNVLLFIYRWMLAGEQNSNARNALKFEDLRLPDLIALYYHCVFLEYHSLKEKTCARLEWKLKSVIPTIEQLSVILAYTPAVAENAVQAVARLFFRPVCYDFSAYLKLASEDPEFGRALDDAIAQLKLSLLRQHNNRPQRRGRSNQTRTDIVSLKRQWGSQQNTNLQQSKNVQTNGNPRLDPAGAVTEPASKAEEVMNTTISRRRRAKRSIPKAKDLAPAATPSQENSIATPRVVLPTVGARKPHPRKAPKPTNGEAGDTPDTPATFVKATPNHLRAGRAPGPRAPLKPVGQAPNYNNPGVSEHRGRTRRRAVEVHRNGEGITTSAREAKPGEMTRTGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE61</accession>
    <name>A0A6A6RE61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_521746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE61"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2503138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="345" mass="37953" checksum="617CDBAAC66E5B98" modified="2020-06-17" version="1">MSSWLHKKRKGELQELASQANVPDEGLLKEDLITALETRLAQNQSTYSKNPVFSDYYKRTGSPLKRERPSPPDAGTVVVSKPRRRQTKLIEREDSQEEATPRKALATRTPRTVSRITSAIDIPASPSQLANVAEQAGTAIDKKARDLWKLQKTRTEEVVEFLRENFSSVVAVQSFVSIIEAAGLQYSTLEWSHPKTPALASLGLKSREFPFPNLWLLLTSDFWAPATLWSLTSIFLPLVASYFVNLTLRSNTQHKTNKKTYTADPLTFNIVKALLAYTIYPLVAVAKEKGFPPVPVAEYVVPAWGPFSSDTVTTISKSVPGGPAGLLIGAGVGVLAALYDAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REA6</accession>
    <name>A0A6A6REA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_533298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="953"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1259"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="571"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1339"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1528"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1587"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1590"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1600"/>
            <end position="1614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2503009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1740" mass="194758" checksum="DFEC4220D9001BC1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Bloem J."/>
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    </evidence>
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        <source>
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    </evidence>
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    <sequence length="1397" mass="154147" checksum="1B322081330D073B" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A6A6Q8Q0</accession>
    <name>A0A6A6Q8Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_586905</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="695" mass="79581" checksum="0199CF184B1B97BF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9M9</accession>
    <name>A0A6A6Q9M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_218365</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
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    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="948"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="14">
        <location>
            <begin position="189"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="15">
        <location>
            <begin position="783"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2488942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125980" checksum="3AC3F92E5EF58A61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9R7</accession>
    <name>A0A6A6Q9R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_531488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="139" mass="15873" checksum="31517D10501A193C" modified="2020-06-17" version="1">MASTNYREAFQLYDKRGQGRVTRDSLGDLLRACGQNPTLAEISDLERNVGTDFDFDTFSKILNRPGGFREPADINDYIRGFQVFDKDNTGFIGTGQAKYLLMNMGEKMSESEVEELFRAVDVNNDEIDYKEFVRGIMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA97</accession>
    <name>A0A6A6QA97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_532063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2489041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA97"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="41472" checksum="38E1B35C8164DA0F" modified="2020-06-17" version="1">MGGDLNLKKSWHPNLWKNQKRVYDEEHKALEERKLIDKLKKERQEERAIEELQKLQEAHGGKTRLNRVDWMYSGPTQGQTGTTEEMEGYLLGKRRIDQLLKNDENKALEKGAAAPVEGVVGNANSARDTAVKVRDDPLMIIKKQQMEAMLKASKEAPRVAHKRKDENRKRSRRHDDDRKERHHHHHRRRSRSRSPRERRPDERRRSRSPYRRRSDDRRRSDSPARDDRDYRRRSPSPRRKSYNDRKRSRSPPRKTYNDRKRSQSPPQTKRKDDMVDRLAKMQADATAVEQERKDRVRQREEEDAMEDDKHKKSDGGRKFMADLHRKTGEMDLGERLGRSRGNYIKNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAC5</accession>
    <name>A0A6A6QAC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_567371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAC5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="328" mass="36343" checksum="AABDAEA1D0F446E6" modified="2020-06-17" version="1">MSRKCEVSFSSASKFFQLFCDVRKILPFSRTMPVYGFSLPSQCPICHPRRASACRCEDKPALKRVLRAVRVVHAIGLTVLEGVNCEDILRVNFKTENNGDRFLERHLRPGSSPVIGFDIYPLPAQLQETKNSFLKRAVLSTSQCDFLVAVLGEALAALLGQDVDESAEVLVNAKSIYRPRLVQGHVVKEQGVTSHNALAFWLKIEDIPVIFDPSSAQFGNNKPVYVLPRMGEGASDHFTAVLGIRALGTTLRDVAKNDPQYAEWAAAIECLVHSAVFTGPSNFSPRWPDYVSQLDLPEDEFEARLAAALLDLSTRAVPAFLGQWRSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAH8</accession>
    <name>A0A6A6QAH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_180468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAH8"/>
    <dbReference type="OrthoDB" id="3864188at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="339" mass="37516" checksum="5EEED845CD1D8657" modified="2020-06-17" version="1">MGRYKHARNAFQYLRDWQHEHDIVEARIWSDAAEAYMEEGGGADTIIQGYTTPEKAASWAQKRDAARKRFVDMALYRFEKYVQVLIPSVPDLAPTPNALNVPVPPNVTVAPAPGGVIVKHNSQEWPTVIELSDGTFAEIGCPHCKGNAIADPQTGALKYLKGIHGISNHMFSSHGSNPNRDTAAIKQMTLRQLTPVEIVALNFNAPGAPKIEKIPCLLPSEGTGSQLPPFSAGDIEPFSQEFDKLGRSDSAGSSILSPHNQGSKDMLDALPTSAPPRPGSSGRKKRPAPPKRVNLLMKHHKEDEMGTDTQNDKMWLERDIKNYRDDIMSWTKSEPRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAJ4</accession>
    <name>A0A6A6QAJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_586984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
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                <person name="Gonzalez J."/>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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            <end position="389"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="415"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="647" mass="70339" checksum="9A33ECE312BE6E35" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    <sequence length="447" mass="49419" checksum="F9D71E16916C1693" modified="2020-06-17" version="1">MDVQPSSRDASGEDAEDPILQEVTATKRARSSKTENGAGAVDGTAERSASRASRKSRHSTSSEDSEKQAALERAAHGESGEAGTMRMEDPPKAGLVDPVGYTTNPPPEGRPVRIYADGVFDLFHIGHMRQLQQAKTAFPDVYLIVGVTGDKETHRRKGLTVLSAKERAESVRHCKWVDEVVEDCPWIIADAPEFIELHKIDYVAHDDIPYGADEGDDIYGPIKEKGMFLVTQRTEGLSTTGIITKLHWCLADTFRIVRDYDKYISRQLKRGASRKELNVSWLKKNELEIKRNMIELRDSIKTNWTTTGQELGKDLRQFWQSSRPASPARTPTTEKTEDGAKSPTFTTASPSALSRLNHLEVPRGSSSVGGRESSDFTAGYNLGLIGGVRSWMARSRRNLNDSRPDSPESGEGSSDERSIKEPSRAQSRGRKGKHVEPADAQMEDPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFG7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="93" mass="10397" checksum="DA0DC1435CE4B95F" modified="2020-06-17" version="1">MLVLFCILTSRFQRAGVFGGITLGLPWMGGDSGWFGGWNSLISSLRRSSLSELLCYFFCRLFLCSVQISHIQISYYLLARRGAMPGLSIDHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFL2</accession>
    <name>A0A6A6QFL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_565886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFL2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="226" mass="25981" checksum="BF2F607917E16DCF" modified="2020-06-17" version="1">MSLHLSFCGRWRPYSHRTSPERNLKEPDLTLSSKSFPRPAILALWLQIPEIQQKINYRSKPPPHYESHSPGPAILRATGCIIEVSARITIEASLQALANPQEAAYGANTHPDVKAEIETHTRRSGWGHYMHDKEMARLWTHQTETRGIAVMAVDAARLSDPFRRAFLRPDGFHPLFIGGWPWFWMVEQGTYIRSTKLCSPIDEAHRHCPNMVGIFTVPLLRYNYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFX4</accession>
    <name>A0A6A6QFX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_531005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2490523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFX4"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2490523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="189" mass="21792" checksum="4D4DAE7E6426DB87" modified="2020-06-17" version="1">MVRKLKHHESKLLRKVDFTTYKSDGNHREHQILRRYAIQKPTDYQKYNTIAGSLKQLAHRLAALDPADPFRRKHEDLLLEKLFDMGIIGTGGGGRGKLSDVEHKVTVSAFARRRLGVVMTRLRMADTVQAAIKFIEQGHVRVATEVVTDPAFLVTRNMEDFVTWVDSSKIKRNIMKYRDKLDDFDLAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH54</accession>
    <name>A0A6A6QH54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH54"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="385" mass="43453" checksum="579BC1448D633891" modified="2020-06-17" version="1">MAHKREEYHSEAARQSPAGKDKRKEWTLKSKRPSMRKSIEQERSKSETVPANRAAVHTVPFPTSCKTLIRPLSSSYSLPSIAQSTPPPLEPLARPLDASDATQSDVNYIDLDSTVGPLVSAIKKRMIEAVSSANAEIIEGLAARDKCIEVAESKSNLDRPELDNLNQKIKEDEKMYRTLIVSIALDKRKRQTLEENIQLNIKCQQSAREEHKKLEIRIHRELEKRFATLKRRLDLDDGEKPSGEGGHHPFKRIREQHPIKIAQCYSHNKTEPEFNEEAEDVCLGEPREAFQDATEYATNYGVNNDANGGAEEDSKEAIDECSHEGVEELPFKEVVGEFLEEDISQQDLDNVGVDERSASHFMPKEEDEDPDYQPSSGTDDSEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH76</accession>
    <name>A0A6A6QH76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_530568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH76"/>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19169" checksum="EC00B2D1C6560EAF" modified="2020-06-17" version="1">MKVMVDDSKPDGHIDRCWTETTYDGKPGSMKLEVPGHWHKYHDEYMEVLRGRMTLYLEGTGSVVLAAGDERLKIPRWHVHSFAAFEGEEAVLKELTDPSGEFKAEFFRNATQSGSMNITDALRAFWEGDAYVSLPGNIKLLDQAFIAVAGTIAKFFWPAKRTYKAYPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHA5</accession>
    <name>A0A6A6QHA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_529965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHA5"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2491444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="25562" checksum="C1A990620B47ECD9" modified="2020-06-17" version="1">MNLFRLLGDLSHLISILILLHKMKTSSSASGISFKSQVLYFVVYVTRYIDLLWTFYLPKSLYNTVFKILFISSSAYTIYLMMTDYKPTHDPNLDTFKVSYLLGASAILAILFPYHYNFTEILWTFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGAYRALYIPNWIWRTVVVEKPTPFWDPISIIAGIVQTILYSDFFYIYYTKVIQGKKFNLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHH2</accession>
    <name>A0A6A6QHH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">BU16DRAFT_530019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHH2"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2491529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="246" mass="26245" checksum="F2DCD47D0ADB20A5" modified="2020-06-17" version="1">MAVRAQFENSNEVGVFATLTNAYAIVAVGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNRKGLLVPTSTTDQELAHLRNSLPDAVKIQRIEERLSALGNVICANDHVALVHPDIERETEEIIADVLGVEVFRQTIADNVLTGSYMALSNQGGIVHPKTSVQDQDELSSLLQVPLVAGSVNRGSSVVGAGMVVNDWMAVTGLDTTATELSVVESVFRLGEGMGPSAINTTNKDTMVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHQ2</accession>
    <name>A0A6A6QHQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_127310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHQ2"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="36884" checksum="461F4148BC385C98" modified="2020-06-17" version="1">MDGDSSVPWYIPLLVRAPTSIALKPPTSPTLRPPTYPTYPALDLSHLPLPEKISHHYHQPTNQMEASAAHQALGITELLEYILLELPIFEKFQAQRVCKDWKTVIDNSSPLQKAMWLAPQSLYSPPNKDTDPADSIQTSWNIMMRAMKSGPISTEFSPLLWGCRDLQMCGIALEAANTKLLAVRDHPFSTRCQEALDGKCKMTWEDMQVCNPPCTSLVVCTVEEPSLAGWIMGAQSRASFKRLENESGVRMGEVVRSLFEQRRNPQYEVPQEVDNRLVEAMFRYYMYSRLELGFALDCEGITGFWQDEEPAPSRLQSMFCDFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI51</accession>
    <name>A0A6A6QI51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase Gst3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_103473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI51"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="42156" checksum="C94092535E2EB9E6" modified="2020-06-17" version="1">MNVILARLRLINNHIQSPTSTIRALSTSMSEDKKNILNWVLPGDKSGEFKRQQSVFRSFISKDPGAEFPAEKGRYHLYVSYACPWAHRTLIARNLKGLQDIIPFTSVHWHMGAKGWRFATAEENVPGENTTPDPVHPDFTHLQDIYYQQNPDYQGRFTVPTLYDKKAQRIVNNESSEIIRMFYSAFDDLLDDKHKALDLFPQNLQKEIEEQNEWVYNDINNGVYKSGFATTQEAYEKAVHTLFSSLTRIESHLAASKTAYLHSAPHVTEADIRLYTTIVRFDPVYVQHFKCNIADIRSGFPALHKWLRHLYWDIPAFGETTQFEHIKKHYTKSHAQINPFAITPVGPLPDILEKEEEVAAVKAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ21</accession>
    <name>A0A6A6QJ21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_564858</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ21"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2492405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="329" mass="34491" checksum="8BD3591EC70E7050" modified="2020-06-17" version="1">MAFTPRGDRGGRGGGRGGFGDRGGRGGFGDRGGRGGSRGGFGDRGRGGARGRGAPRGRGGFGDRGGRGGRGGARGGAAGAKGGQKVILEPHRHAGVFVARGKEDLLVTKNLTPGESVYGEKRISVPSSDNAVAANGDAAPATNTEYRVWNPFRSKLAAGILGGIEDIYMKPGSKVLYLGAASGTSVSHVADIVGPEGTVFAVEFSHRSGRDLINMATHRTNVIPIIEDARHPLKYRMLVSMVDCIFADVAQPDQARIVGINAHLFLKMGGGVIVSIKANCIDSTAAPEAVFAREVTKLREEMIKPKEQLTLEPFERDHAMVCGIYQRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJE9</accession>
    <name>A0A6A6QJE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_551811</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJE9"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000266">
        <property type="entry name" value="ALG2, alpha-1,3/1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="215"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2492090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="461" mass="50600" checksum="87EC7D1383AE106A" modified="2020-06-17" version="1">MAPKPQNIVFFHPDLGIGGAERLVIDAAVGLQSLGHKVTIFTSHCDPRHCFDEARDGTLDVRVRGNTIVPPTVLGRFSILCAILRQLHLIVQIGLFSSELRTLRPTAFFVDQLSAGVPLLRFLLPDVRVIFYCHFPDKLLAKQGGLLKTLYRGPFDWIESWSTGCSDTIVVNSKFTKGVFAEAFPGLKNRRPTVVYPCVDTSSADEAEDLKPLWSNKKVLLSINRFEKKKDVGLAIRAFAGLSEQERSTSRLVIAGGYDARVAENVSTYNELCNLASSLNLKHATAKTVISAMSIPDDITVLFLQSVPNAFKSTLLATSRLLVYTPRNEHFGIVPLEAMMAGIPVLAANEGGPTETVISGQTGWLRDVSKVQDWTEVMRVALEDGTGEERLQEMGKWGRERVKGEFSKEKMAQRLENEIEAMEEVDRPPIASTSSIVLGAGVQGAVFVVALWLAAKAGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK12</accession>
    <name>A0A6A6QK12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_542253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Bloem J."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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        </source>
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        </source>
    </evidence>
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</entry>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18838" checksum="A662E4174EBE2C66" modified="2020-06-17" version="1">MFYIMYLTGLCTRRHWPDPLYECYRTRHGFGCTVRVNNREYTTDVDYETDELARNAAATRAYMICRNFSVNDGMYPGQRQGQGGVIQGLPVAIGTGRRNTYSSNTDYDSGSSTYAETGSGGNSPRSSDCGLESASRRSSKSSTSGSCYCGRGTIRAYERCNSCLRESGYN</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <comment type="similarity">
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    </feature>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="7">
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
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        <ligand>
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        </ligand>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="442" mass="49068" checksum="F65C03999A8C9261" modified="2020-06-17" version="1">MGQENSLPLVDEDTPTQTLENRSVEAVGRMLKALEKRGEEGERGERVVVMTGAGISTSAGIPDFRSPTTGLYANLARLNLPYAEAVFDIAYFRNNPLPFYTLAQELYPGKYRPTITHSFIRLLHDKGILLKLFTQNIDCLEREAGVPGDKIVEAHGSFARQSCIECKTAYPEQGMKDAIREKRVPRCVDKACNGLVKPEIVFFGEQLPAEFFANRDLPTQAHLCIVMGTSLSVQPFAGLPALCREETPRVLLNMEQVGGIGSRPDDVLVLGDCDAGVRKLAEAAGWLEELEALWARTAPEKAAWRLEEVRRAKEEEERKSNMTADELMEEEVAKMGREVEETLRLEKEQHKWLEEHYAGKRAAMREQNSWLEEHVGGKAAMIGTEGTENAAEDGAAAVRRDSHPEFTEDSGPSDEKVMRPVDEDSGGGLGHVFPFLAKRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QNL8_9PEZI</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
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            <dbReference type="EMBL" id="KAF2492497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29439" checksum="3AF9FF476D0BC820" modified="2020-06-17" version="1">MDIVRASENSPPSLLLSLPAELRLCIYEFVFIPTHYAGPKLPDPSDKASLRLSLLLTCRQIKEEARLIAYSRTSFHIPNLIEPLLDRIFLLREPLRNRLRYVTITLNLSIAPKILSFMDPWLMELPLKQLTISISKLRALPQESAIISSTVEPESIEDARAYSYIPASSLRFEIQMKNFKRAICRGLTEPSNVKQITLLHDGCCCGAKFIRFHSMLCLLTESEDKFAKRWDVSLDEARHAIDIVAASAMHSVGASSAHASF</sequence>
</entry>
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    <name>A0A6A6QNU9_9PEZI</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="363" mass="41044" checksum="F49B95FF17EA5574" modified="2020-06-17" version="1">MAFDGILSLLIWQFFIPRFVVGFVQSTLYSIFIRAGDPKPAVGSAKFVKHRKQILMTLYTAYFLFSLYEITHDIESAGNLYKDLGVPLDVDDRKLQSRFRRLTIQYHPDKINSSADRDAANSYYVHLLEARDTIVDSVKRFAYDRFGPGVLQCGKKCLTTRDYVEHSLQGTLLQYVAIIVGLAGANALGYFNEGAYWRYLAVLALMTMETRIALRPDHPPALVKIFNPLLTTFSQHAPYLPFQIVTLLRRGTYTLAIYLQLLIPLYRIQPQQTNAEGEEEAIHKQLDRLTQLAKDAQVDASRLLELEVIPFKADDRLRGDVKNALKGYLVNNMIHGKPEVRNAMGMSLAKRRAGAPAGARGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
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                <person name="Cannon C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="618" mass="70403" checksum="6EC531A24145C854" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPX4</accession>
    <name>A0A6A6QPX4_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Baker S."/>
                <person name="Barry K."/>
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                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1474"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1565"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1595"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1626"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1638"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1654"/>
            <end position="1672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1688" mass="184325" checksum="89398C52C74FD3D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR00</accession>
    <name>A0A6A6QR00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_589537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR00"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="579" mass="65101" checksum="57DDD762C12C9F87" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR50</accession>
    <name>A0A6A6QR50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_462380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR50"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="546" mass="59066" checksum="29B0B7B5CE428B7B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR55</accession>
    <name>A0A6A6QR55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_618845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR55"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Lutzoni F."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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        </source>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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    <protein>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
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        <property type="protein sequence ID" value="KAF2494037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="60"/>
            <end position="248"/>
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    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="602"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2494037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="89001" checksum="FAD0FF5454F9702D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT49</accession>
    <name>A0A6A6QT49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_396704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
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        <property type="entry name" value="Znf_CCHC"/>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="386"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="388"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="545"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2495688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="637" mass="70536" checksum="91CE8E1886844CD7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUL3</accession>
    <name>A0A6A6QUL3_9PEZI</name>
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            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
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        <name evidence="2" type="ORF">BU16DRAFT_617404</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26971" checksum="3CA39CDCC6ADE586" modified="2020-06-17" version="1">MNRFSDYKDQVTANIDRLAKFRTGWLTTWTLRVRCDDKLKQCPEKEDPPDDPCDPPGDGDPTPKKPTKIAYVATVDPYIDHMFFCPSFFLRPKLDDRIATTVNNLVQANWLDNYANRATTVAHELLHISWIGSPIDSPARNQLIDIFMPDGNWKAYRTVDCKYLAHSEIEPDVQHVNNVNNYMWWFLANYIIHKYDFYPSGSTWLTTLDPPLSPPSVANLAITNSTDVEIGWGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWW9</accession>
    <name>A0A6A6QWW9_9PEZI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_561138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWW9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="231" mass="25728" checksum="4778246BFEBAD786" modified="2020-06-17" version="1">MWRDGLWGSKTLNVTRKAGRQSGLSNPKGQETTWEIDRKASDAFPSNAAGWKHVSCACPESKEKSLGTTWWWLNQAATMLESHWPRAASDMIGAAGVVRYALDEMESSPRGSQSGCWLVLFLAQALAEGAPHVVIRGRSDSGHHLLEEGGSHRRAMRRLAGNNMRGVTGRPRCSWRCSSRCRRRKAAICHPFTHGVLAQHYAFLRHDGVNTVPLLHRYYPDAALKRVDSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXV0</accession>
    <name>A0A6A6QXV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_581236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXV0"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="29528" checksum="FD9737ADDC551AF2" modified="2020-06-17" version="1">MDQRIAPKQVPLSTLLGELAVFKEEWLKSPFSNQLRGLLLVRSVWNIDRAVVVGLGNMTPLLDYDDDENEYRRRRKQRLTQLTIFLDIVDILSTAQGGRQIKIYASDPAFERIDKAFLKKLGIKVVKEAEEHVTSSTFVYSPFCPWYVGVAAIRHSPQLYLGVSIQLIMDLHEPRQEPQYGFDMTEEQAATTEKFLQTRVMQSFPGLEHYPDSEEGMQWAEFKKLAPELVALTSQALWGAFSFYWPKSGPLPPVTTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY03</accession>
    <name>A0A6A6QY03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY03"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="29631" checksum="6A573286CA249A51" modified="2020-06-17" version="1">MPPQPSQSTILHPLTTPALLNRVLASQPPAPATLVICSTRLAFLAHLLHATSTPSSTYPDTLTPTLHTLATSSQVKLVFCPSVASLLGWLSVYKGTKGVADTAAEADNGEKKRTIRGAEAGSTRKLYLVDPLALHSHTPSFSAQGLGRCFAAAVEAAGRAGERLVVVECGGKKSIRVGAEEAGIEGGDADMDGGEDGGVGGREDSTEEGGRAERDEDPWEQEVPILNTTMRRLGAGSGERGWAGRTVKIRTVAERWFRFEVVEGGMEIPEEDGERMDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYV9</accession>
    <name>A0A6A6QYV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_606206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="224" mass="24431" checksum="CD3876D389AC83BE" modified="2020-06-17" version="1">MYHLVKGLYLYATSKEEYSILLLGLDNAGKTTLLEQIKAAYTSTASSTGPNLKTVPTVGQNVSTISLTEPPLYLKVWDVGGQHALRGLWQSYYASCHAIVFVIDSTDVGDADIASLGAGTAEDGEKGRLEECRKVLESVLQNEDTEGVPLLVLANKQDREDCVEVVRIKEGLVRKVFEGESGGSVRDSRVLPCSALTGTGVQEAVEWLCSRVRWNKEARPPVMR</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        </citation>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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</entry>
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    <accession>A0A6A6R0D6</accession>
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            <fullName evidence="6">HTH araC/xylS-type domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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            <name>Zn(2+)</name>
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        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="323" mass="35385" checksum="E36B53B3F55873DF" modified="2020-06-17" version="1">MPYMPHPFPPFIQTSSLSRSTLSIIKMSSSFTTSSSRWAALTTRDPAAYSAFIYAVKSTNCYCRPTCPARLARRANVVFYPSAAEAARDGFRACKRCKPDAGDEIMLTRLNSRKDAADIAFEKACSIIVAAVAKGNANELGLKDLAKAVGLTPRYFHKVFKDRMGVTPAQYVKLKQGEMATVQGLDLPQEESKEDRQRVQNGGEEELGFDFDFTDLVNEEMMSGGESSLSPDVPTPPLLDGSLDGILPDVFADAAGEKQMPFYSALFTFDETGLDLLDLGTFGGVDEIEHAWLNMEDDKSLNSLAPYDFNSGNYADSNPFIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0P7</accession>
    <name>A0A6A6R0P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_615400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0P7"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="283" mass="31070" checksum="10B7B0AEFA9EB9FB" modified="2020-06-17" version="1">MSLARAMTKRMRRSDAPPAVPTRSASARNPGQHIDRKKISMPVALISTTNMLSYNAPDIATMRHASNGSTSTHLSGDDSDHTTSTTRSRSSSNHSRETLTDASSVGSSPTSPEPNHLSCYFPPTNPTRESISSGKVIRKSESMDSMPAATATLSSPPIPQRALSHSKRAHERIANKRSLQNMKPPSSIHARDSSRSLREQRMSVDMFKNTPDEHPFGKELEQLNEVVEEFGGVARDAEMDEDMAVMAKLGLASFRATDYLSEIQPLFNSLFETRFLAAPTAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Z1</accession>
    <name>A0A6A6R0Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_605982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Z1"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="375" mass="41443" checksum="A1E7853F719BFAF7" modified="2020-06-17" version="1">MASSVSQQGQLDLLRREYLQLVEIEHIRWPDAALLKTADTQAWIYEKLIDRDMLQSPPPDRYQVRFLKSLVSKIESAIEDPEEEVRHYLHFLSAFSYPISLHEISEDLIFRLSTLLSSKLPSDAFAAQQRVFVTYAFPNNPSSNEVPDERTVTILESRSVLASAGSTGLRTWESGLHLGKFLSTAEGIATVRGKNVLELGAGTGLLSILCAKHLGASRVTATDGDEAIVDSMRDNVFINGVDAGASSTSVECAALKWGFPTDATAFEEDYGLGKLDVVLAADVTYDKRLHLPLVSTLSELFDIRPSLQVLIAAAVRNEQTFEAFVNACKRNNLGLADNDFEMVPIELQDGPFYSAAPIRILTITRSQERGDPFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R104</accession>
    <name>A0A6A6R104_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_316267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R104"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="202" mass="20635" checksum="E14D92FAA72D60F8" modified="2020-06-17" version="1">MPTASAKAPSSTHSSAKAPSSTHSSAKAPSSTHSSAKAPSSTHSSTKVPSSTSSSVKAPSSTSPSAKSPSSTSPSAKAPSSTSPSAKAPSTTPTSTTQAGPVAIFSSLLFSGSAVVASLCTCIEKPLTTTVTSVPIISNLVTATGISSVTSTSTANAIGDNRFLFLFIPVRAKQWLVLQLRIGHGLHLLRICLYRRRSLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1H8</accession>
    <name>A0A6A6R1H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_548177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1H8"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR034098">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00006850"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2498389.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R269</accession>
    <name>A0A6A6R269_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2498858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KAF2498858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="173" mass="19331" checksum="B4BCC17EAE2727C0" modified="2020-06-17" version="1">MLSPRLPHRVHVIRYTPHRLHAMTWRCLAKLIGARRSRDEGADKTPTSNFTPTLLSPLPFRSSVHVGLRSFFSLFSMIAAGVLLTECLEGLLRGPSTQSRGFFQVWHHASIQTTRACIARGLLVLYREGGPAIATQTVLPGAITDWVGRPTSFATTIRRLPRHRRKTCIVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2D9</accession>
    <name>A0A6A6R2D9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_558909</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2498871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="200" mass="23367" checksum="C964D7EE828682E5" modified="2020-06-17" version="1">MDHCLRKALPQVLLACQLEPGSMLRLAHSLHCEWIFKEAAAHLVGLGNIAYERQRIKMNEKGPLTNLETMLTTKYISFCTKLKDIDFDLLKAAPMEEDDIWEVLLTSHFRMWFTSELVEGYGSSLDRSKYASVYRQIEENDWYKHGRWNNFVESLPGFTEYPYDLDPLLFTRRLADILKSILMVYSTQYRTEHSGMVVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2G5</accession>
    <name>A0A6A6R2G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2406 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_558608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2G5"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42550" checksum="0145C9B093CA4761" modified="2020-06-17" version="1">MERPQQRQRSATTFSFKSDKSHSSKNQEKHHKESLRESSEEKRRTHLHSKSKADPNAAMSENQPMAEALEKPTLQSLRSFQHTDVYGNPIAEPDLSNPTRPRWERPLDTIKSFEAAIDNEYKRRRSVLRAESSPDVNNGYQSRRSSYHGGGYENSRYSQAGGQVGSQVGGYYGSRAAAAARESNYADSQYGPMGGAPPRSRYSQRLQSDPALNRYPPAQGQGVYPNPTPGYQQSRDTVQTERSNGSHSDPWANSTDPSSENSSIERALPVQKPVQNIPDGAEYGFNGFGGTPQFQGPILEEYGNGNNATYAPRNGGPPPTNGMHFQPGAANLPPPVPAKTTGPIKLGGNYSEQPPQVDAGARPNTLQRQNTDKRKSWFKRRFSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2X1</accession>
    <name>A0A6A6R2X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_301382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Y7</accession>
    <name>A0A6A6R2Y7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Midasin</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">BU16DRAFT_571476</name>
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    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <text evidence="6">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
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    </dbReference>
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            <dbReference type="EMBL" id="KAF2497757.1"/>
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</entry>
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    <name>A0A6A6R3C6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1146" mass="125722" checksum="5EC443812ECC4CF2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3W1</accession>
    <name>A0A6A6R3W1_9PEZI</name>
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            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_453820</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
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            <dbReference type="ChEBI" id="CHEBI:64615"/>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
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    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
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    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6R3W1"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004144">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2499239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3W8</accession>
    <name>A0A6A6R3W8_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_579713</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3W8"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="18">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="577"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="581"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2498620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="673" mass="73907" checksum="C025ADFE37EFABB9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R460</accession>
    <name>A0A6A6R460_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_558598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R460"/>
    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007011">
        <property type="entry name" value="LEA_SMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04927">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="35396" checksum="E96DB6D776D141B7" modified="2020-06-17" version="1">MERLTRANEAASSKTAGLDMKSFTDLAMMVDAKLDAATDGVTLEDLKLFEDVVAKMQKKMEAAMAASEGVMESAGAPNTRLEHELKREITKVEPKIGDGTITEEDANRLHSLETRAHGRTQKGGVTAHAQSIAAKKARSRGSSVSREAAWVPNYLPAAMVDITTPNPIAFLPYGVPPALAEGTSAKDTRPRGFSTDREPAMLRSLSSRSSSDIASLLRAGHESSRSAPNMAKILTKLQAQQAKQTSFREAAAAIEPKIKEAPETITKEEANLLHKLEVRAHGSTEKGGITAKAMSLARKNEAAKVEAARMSAESSKNVSDNEDEDLTLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4E3</accession>
    <name>A0A6A6R4E3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase Rv2170-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_524724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4E3"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="1">
        <location>
            <begin position="272"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="364" mass="40079" checksum="81BED9D677F1AF70" modified="2020-06-17" version="1">MSYTDKVYEHPATSPLLLQALRSYLPYSIPLYRRIQAQIQSPTAHVLATFPPAEQESSTAPQWPKCFAACFFDRSSRPETEMWVFVSGEVPEHASHGVESASQGSDETENAEKLSCPTCTSLFLSTLRHASTFPLPPIRPENQKHLDLAATATSLQSFKGLSLSIEDVPPVAYLTHLLIPTVLTLGTLNSKLLPVLTERHLVREEFPGLNAPCGKFILKVSSTPTPKPLPEGLRWGEVRAQDIATVQAGTAIPRAAATLLQLKSLAVFPSNSEKPIAWVFLGHDGSLSSLHVKPEFRGRGIAKSLASKLFRDNVSNTAEDEENQDDWAHADVYQGNVQSESVCKSLGGKPWWTVYWVRLDLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4E4</accession>
    <name>A0A6A6R4E4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BU16DRAFT_524094</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000333">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative (AFU_orthologue AFUA_1G02140)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="43"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="142"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="756"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2499628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1561" mass="176292" checksum="F5E2DFC223E207AA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4J4</accession>
    <name>A0A6A6R4J4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_456317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="272077at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="587" mass="64359" checksum="540EE2344CF5BD69" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4V3</accession>
    <name>A0A6A6R4V3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_455939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="43656" checksum="A92DD5E0F1E4A434" modified="2020-06-17" version="1">MASPTTITPLPPRLPDSSTNPPAHHIGAPPRSFKNPWPSYGSPGVSGALKARWGPHRNFVPVPTDTSQLVTVRTDPDFGALLPASSLKATWIGHASFLVETPIQPGSARGVRILLDPVWSQKVGPYGMLGPERFVGLPCEVEEVGEVDAVLISHDHYDHLDSPTLRRVRERGEGRVRFLVGLGLRHTLVGLGVGIRADEVVELDWWGGVRVEVEGVGAAEVVCTPAQHGSGRTPWGFSATLWCSWVIREVKGRSTASSTASTLEDGLEKGALGKALYFTGDTGYCCVHSDAELSSAQAPVPPCPAFTEIGQLFGPFDLALLPIGCYLPRSFMSSQHSSPDDSISIHKDVRSKKSIGMHYGTFRGNLSAHHEPVTEPPMRWKKACEEAGLEWGAEIGLCDIGETVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R583</accession>
    <name>A0A6A6R583_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_524104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R583"/>
    <dbReference type="OrthoDB" id="5398396at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="156" mass="16951" checksum="08F2B9B71B16A953" modified="2020-06-17" version="1">MGWFTGSNSRSSHSRPGYARSSAGSSYSTHRGSTSSYKRRPRDGYIQYMIHKFKRLLRQVMDYARRHPYKVFFMVMMPLISGGVLHKTAKQFGIQLPDFLKGNSAHQSRGGGGYYGSEGYGREEIGGGMGGMGGLSSIASGLGGVGGMVKMAQAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R588</accession>
    <name>A0A6A6R588_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_524719</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R588"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="79"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2498627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="32630" checksum="2ABD58880E3E66B2" modified="2020-06-17" version="1">MRWPWSQNPHNVDDSDRKRPVSWAESLNTTDWSQYTEARTVVPSVLLTITTLTLIRLYKSYLRRIPSVNYIKPDLFRRRSLFGKVTSVGDADNFRFFHTPGGRIAGWGWLPWKRVPKRRDELSAKTLHIRIAGIDAPEMAHFGHPAQPYSKEAYDWLSAYILNRRVRAKIYRRDQYDRVIATVFVRKGLFRRDVGLEMLKSGLATIYEAKSGSEFGKFEEKYRKAEEKARLATKGIWTQPSLWERLRGQRAKDMESPREYKTRMTASDKTEVKKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5R5</accession>
    <name>A0A6A6R5R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_454697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5R5"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="232" mass="24503" checksum="7F9ED45A099DD42F" modified="2020-06-17" version="1">MAANPVVLILGAGPRIGAAVAEKFASSGYKVALVSRSGSATKSGEGFLSLKADFTKPDSIPALFDAVKTEFHAAPSVVIYNAAALTPPPDKDSVFSVSAESVASDLNVNTISPYVAAQQAVIGWETLPKETKKTFIYTGNITNVSILPMPMMLDLGIGKSASSFWLGLADVLYSAKGFRFFYADERHGDGKFKGMALDGAAHAEFFAQLADHEGTVPSHATFVKGKGYVQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6A8</accession>
    <name>A0A6A6R6A8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_452060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000051">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="281"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="535"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="723"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="679"/>
        </location>
    </feature>
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            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="861" mass="94779" checksum="E456DC6E35AA77AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6G8</accession>
    <name>A0A6A6R6G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_272871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="423" mass="46464" checksum="A3FC6221F2133CB8" modified="2020-06-17" version="1">MPAWVDGEEASTSNVSSFSELPPFSACPGARHGTRRAFSTSVASEPQARSTLPSSTSVSAPSKTFAALKRCMMPLVRWVVFGVWRAIARGGRRSGEEGHRASCAMAGISASSMSEWAQHQQLRGWPVNQGHVPGDPSYAHLKTRQADGPSIEGLGTCSLRTWSPYRATPDPTDRRWPSLPVPVPADCELVGRYVLQFTPIRLAPPVSPHVPTLPMYRSHSGATITATDTNSFRSGSRNRWGNCCKIFYKAPSPPRPRSSFLSSQSPQTTTDTLFRAIFRFFCTVSARFRSSFSQDPSKQPRFRHFFSQKLPNNHHVCPIRRQNRRDRGQLPPPCPPNVAPPPPPPATPPRPHRGRVARRPRPTVAHGLGPMWPRSAPFRGPNGPLLPHPGWGLRLPGLGWGQPVPELHGAGARCALRGRRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6Q7</accession>
    <name>A0A6A6R6Q7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_247291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3691873at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="157" mass="16939" checksum="9841BDE1A8C18AE1" modified="2020-06-17" version="1">MPPGKTARHMLGQEAPGEDSERRAAEFRQAGAMTCWNDRQLASWFRHSLGAGEHGVEFWDKGVSSLSLSADARLSVQPGARSNAGSPIPNLAHNGSLCSRRSAATRAPVEPVKTINKELITADGSGKRDRTKEMDPGLWSAEQRVDRASFCAALVEP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
    </evidence>
    <sequence length="347" mass="38404" checksum="8C8E7C53BE1DB6CD" modified="2020-06-17" version="1">MSAAPDPKSISDADEAVSQGSLERPSPSHLSSNEDDEKSISLIQAVEYDDYDLVVEKLKTPQDLEVEEFGRTALNNAHSLPIVLALLAAGANIQKISHEGRRALVGLSPETSEEPLSTISSEQFLSGCNRLFGTKNPDRLDMPFWDAMIRSGKNAWVAGNYFKDKFGVKRDFPGTPVWCAERFGQSITRLPDGRVIQIGGEHEDSYDPDFCIYNDVWEHHPDGSFVVYSYPEDVFQPTDNHSATLMGGYIYVIGCLGYGENPRYDHTPVYKLDTASFAMEEVEVVGEAPGRIYKHAAVVVSEHEICVSGGKVSKTEEGPNTDNDTENILNISDSTWRRKTPDHTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA28</accession>
    <name>A0A6A6RA28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_613535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA28"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="57"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2501685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="48608" checksum="376C81FAB09C8302" modified="2020-06-17" version="1">MSLPKVPPEVLQKMLDAPAHAPPAGVIPNFIDPPSLHTTSLVIVIVCLIIPTIAVWMRLYTKGKIVKSITLEDYVLLLGWVCYVGAYYVCAFLIIDYLPGVHQWDVQVKAISKYLYYLHIGTLMYGITILFIKLSILIQWIRVFLTPASRGPMFWAFHALIWANIIFYVSCTFIEVWSCNPRAKIWTPLLQGGKCLNTNAIAVSSGVFNTISDIAMVLLPQRVIWKLNMSRGRKIGLSAIFLFGILACIASLVRLYYCVRVFESHDYTYYTLLMALGSFPEMTAGFLVICLPVLPKFVRSMFGEDILTRVGFTKFRSYFYTSSGSGNAASGSGRWRNLRFLNSPSVTGKEKSAVEATLERNDSGAAVEVDAEKEKADACIVRTVQIAAEDGPRRSGDFEARFQATHPWAKEEVPGAAADAFDERNIGFVGEEDSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAD8</accession>
    <name>A0A6A6RAD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_577760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAD8"/>
    <dbReference type="OrthoDB" id="5241710at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="223" mass="24653" checksum="2EA6E03D053B0C3C" modified="2020-06-17" version="1">MAPTNVERTHTLRLITVLTFIPCLGLSLGGAIACNGIIIGMGILPLFCSSLSGLVHMTHKGRTLALRRPDRSVFIDVVIGCMFLGVLIPFWIVERRRLAWMIKQVDFIIVETYASALLMVNAAIHFYIAFTQMYAAVSSAGFLACRECEECRRKAGRDTEQRTHDGAQYSPLLNPDEEPYRDSMDTVTGDATEDPQAKLSVEAVEEVRPSSARGEEEAMLAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAG6</accession>
    <name>A0A6A6RAG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_522599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAG6"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCR5"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF4">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2502668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="35570" checksum="7549D7905BBF5DD0" modified="2020-06-17" version="1">MPSSNHESGLTDESATVRVTLLDGGSFSTADMSKLHANAKPDSFRLYDWCFHVFHPSSGRHILWDVGISSDRSAYTPLVLDVQWGSANPVGPGNTLHEQLEALDVSCEQIDTVIFSHAHWDHCRPIQSEFPKAKGLFGGGTKTHCSPGHLDNGVATTKSLWDGRFFDSDGYASENWAEITGEWKQFGPFERALDFFGDGSFMVIDAPGHMPGNLAAAARLNSNGDAPSWIVLASDCCHSRELLDGHADFAYFDVPGGKACLHDDVNAAKDTLRRLQEAEKGHGMHVAMAHDVEWLRQGSDEVLMSILPTENREHFLQAVRAGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD59</accession>
    <name>A0A6A6RD59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_449318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD59"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
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    </dbReference>
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        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
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        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="168"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="571"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2502619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="934" mass="105221" checksum="3A2DA4554EF1C8C6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD63</accession>
    <name>A0A6A6RD63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_612009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD63"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025519505" description="DUF7580 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="212"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="585" mass="65710" checksum="08A0BE37A00C0FEA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDJ3</accession>
    <name>A0A6A6RDJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_9643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502462.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19565" checksum="FCEBF15477774750" modified="2020-06-17" version="1">MAAKRPRDDEDARASKKHKKGFSVGPANLPDGVHKRKVQKIKREIIHKSKIKKDYAKLKAREQAADPPRSVYEKFDDGEQVEVAEPTVEPTLEPHPDRQVLLDRTSPEPTQPPERPQSRTPRKRPRPQPFSREAEQARLKAREEAEKQREQKLAERERYRKVKRLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDL6</accession>
    <name>A0A6A6RDL6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">BU16DRAFT_521213</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
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        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HMGB"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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            <end position="883"/>
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    </feature>
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        <location>
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        <location>
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        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502496.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="892" mass="100973" checksum="C4CFFE95E4F7D5D7" modified="2020-06-17" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDX5</accession>
    <name>A0A6A6RDX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_554810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:outward rectifier potassium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    </dbReference>
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    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="463"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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        <location>
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        </location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2502771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="757" mass="86183" checksum="D8A031584A3CE81F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE86</accession>
    <name>A0A6A6RE86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_554117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE86"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="33207" checksum="C72B10846EED365E" modified="2020-06-17" version="1">MSTGHLTFAFESLSPTSSHSQNLQPFIMSAGHLTFAFERVHAEVCDASDTSCLPFSLTVHGLIALDMEADAMEEGKHLQSQLNVLEVKHSQLLKAEQNLREQRNDLEVMRQKVIVYERARVELKQTELRKQLPEMQLTATSCSLVWESSSRSTRPLQTYLPSWGLAASIFSGLNLLLEGTVFRDGKLHPATRYNKVSGATASRGIASVGMASEDWLIPLRHATVERIHRFEHEAGFYSGDGFDKNHAPDLEEGHYNFQKGDQGHGKEYQGQESYEDTAGNSGDGAGLDEMNYDGDETGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE98</accession>
    <name>A0A6A6RE98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_521629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE98"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="376" mass="41386" checksum="32CEDC7BA7595F7F" modified="2020-06-17" version="1">MAKDPVPATSLPGEINTASRYAQPHTQRSSSPPILTPQPSRSLHTNLNRLITSRLPLCLPPHTSSPHLYTTGLLHFAHVYLTFESLWHDLTLSTHQSTPTSPLLSFLLVDPWDADTDSDPENASPGPSPRMLAFLASLRPTGLARSSRLRKDLETLTGLSSTDLAVSLCQFPGAKVQEYCAHIRKVVGKKPHVLVAYAWCYYMAVFSGGRWIRGELRRGGEEFWRKGGAQSGGETEKEEAVSLNEAGLSFLCFPGLEDGEDIKAEFKSRLAAAEELFTPQEREDVVQESQEIFRYSVGLVEELDELLATNAEKVAAVEAAQQARETARRKDAQAISSSGLLHSRWLQSPEVSTVVLSLGCVAWLAVYLFMGSDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFJ9</accession>
    <name>A0A6A6RFJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ash2-trithorax family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_555151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFJ9"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="5">
        <location>
            <begin position="205"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2503132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="591" mass="65406" checksum="A8A4C7BBD1A77207" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG63</accession>
    <name>A0A6A6RG63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_589070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503352.1"/>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="152" mass="17144" checksum="9D787F8AF000148F" modified="2020-06-17" version="1">MPTSSHPIYGGTGPPTSRHDGVIAIIVFSALTTAVICICFLKCVLIRRKEVAKTKRQAQELYHEFGYERGVRNRPLVEMLSQQMEALEQTEVPPPPQVQVLQQPQEAHLREEIREETPATSSREKVVQATSSQGRDSELPVYEEDMPPVYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9H7</accession>
    <name>A0A6A6Q9H7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_568040</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9H7"/>
    <dbReference type="OrthoDB" id="5425374at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="14047" checksum="2CC6B60E59DF6F64" modified="2020-06-17" version="1">MRISTGITPARMLFGQEYILLIDLAIPTWQALPWNTVRTTADLLELRARQLQRRKEDVKEAVARTIRHRLNNKEEFNGRKHIREAGYAAGDIVLLWDSVREKDISRARKLSPRWLGPFRV</sequence>
</entry>
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    <accession>A0A6A6Q9V9</accession>
    <name>A0A6A6Q9V9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_213190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="407" mass="39923" checksum="A1ABE61D913A8B55" modified="2020-06-17" version="1">MPVIEQIKNKVENILHKDSNTTGTTGTTGTTGTHTGATGSHTNTGVGHSANNEHGSLLDPTGRTGETTYGNTGHATAGTHTGTHAGTHTGTHTGAHTHSANNGPHDSGVANKVDPRVDSTTGTHSGATGGHVNQGLTGHSTATGAPHNSHAANTIDPTVNTGHSTTHSGGLTGNTHSGGLTGNSAAHTSNTANNGPHKIPIANKLDPRVDSTTGEYSSNTHNTGATTGGYDGTHSGGLTGGNTHTGTHTGTHTHTANNGPHDSALGNKADPRVDSTTAGYGNTHTGTTGGLTGHQGTTGGLTGHQGTTGGHTGHSGTTGGLTGNSGTTGGLTGHSTTTHGAATHGHTAGAPQYSNELPGPAANTAGPHKSDLLNKADPRVDADLDGSKTIGGNKTYAAGQSGQSGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAJ2</accession>
    <name>A0A6A6QAJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAJ2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="94" mass="10065" checksum="0027663ECFAFF094" modified="2020-06-17" version="1">MEMGPKGGPEEARMKALGARSSPKARLSRLSGEPGRRVREGPGNAPWSVRNLAKRDFAYVSVVVLFLTRRETKVGAGHEALSPNGTVSGALSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAU7</accession>
    <name>A0A6A6QAU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">BU16DRAFT_598050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAU7"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="14"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="498" mass="55174" checksum="D8B736044FBE202B" modified="2020-06-17" version="1">MKSTTLGKIRAFWLGSVVCMGGFLFGYDSGMCVFSPVLTLTCHASGVLTLKPFVSDFHYSNKHKTRINSLSVGLQQAGAFAACFVIWPITNRLGRKKSLMLSSAVFCIGAIIQTINTHSLAAFYVGRIVAGIGLGAASVVVPMFSSEMAPKEYRAQIGSLFQWFYTFGIFTSYWVDYAMTKRVAPVSKQWQIPIGLQLVPAAMLGFGMLTLKESTRWLTKKGRHEEAWESLKWIRADESQDTVDEMVEIRTGVEIEERETENFQIKELFERDNFKRIFTSFAVFTAQQATGATAFAYFGPQYFKLLVGGGDKDLLLTAIFGAIKVVACGIFVLFLSERIGRRQSLIWGAAFMAACQISAAAIVKNKPAPANGHVTSSGIATVALIYMFVIAYNLSWGPLPWPYVSEIFPTRIREPGIAVGVSSQWLFNFVFSLSTPYMIDGLGWGTFLFWGIADIVIAIGTFFFLHETKGLSLEEIAHNNFGKAGNFKDVENEHIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAV0</accession>
    <name>A0A6A6QAV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_173299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAV0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="192" mass="21237" checksum="18907191A0DA0722" modified="2020-06-17" version="1">MGGSVIIVDKPTGPDYCKRVVCSSRQLESIFSPSSTEHKSAIMLPTSRFLALLLGVLAFVFSTTYAAAVPNASRSDPEHGGHLVRVPMDGEDEIANTTTLESRISSLHGYIWKTECTGDYFIWRDVTTGCITYQSNGHQERMYSLYLERGCAVKFFEKLNCGSDSDAIAHLNWNTAGCFGWDLGFMSFYANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB89</accession>
    <name>A0A6A6QB89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB89"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000098">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17486" checksum="2EA1726885BD19C7" modified="2020-06-17" version="1">MASTKRLLKELQDYQRDPNDALTELGPVSDDELMHWTAVMKGVNGSPYEGGRWKLDIRVPSNYPLAPPEIKFINRICHPNVNFKTGEICLDLLKNNWSAIYTLSATLTAVHQLLTSAEPDSPLNIDIAALFRQGDIVGAEALIRFYTESERWEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBE7</accession>
    <name>A0A6A6QBE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_531760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBE7"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="503"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="305"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="605"/>
            <end position="607"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2489471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="651" mass="73150" checksum="C7891B699CC308BE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC30</accession>
    <name>A0A6A6QC30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_426430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC30"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2489701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="56" mass="6506" checksum="902845BE4331043C" modified="2020-06-17" version="1" fragment="single">MSHDNVWYSRPRTYGKGSRSCRVCTHPAGLIRKYGLNICRQCFREKSADIGFVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC64</accession>
    <name>A0A6A6QC64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_553037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC64"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="131"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2489600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="554" mass="62244" checksum="017A50C32452FB45" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCA9</accession>
    <name>A0A6A6QCA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_566752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCA9"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF14">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="589"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="653"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="732" mass="79142" checksum="1D38DA97A8236187" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD26</accession>
    <name>A0A6A6QD26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_553199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD26"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="203" mass="21635" checksum="8F1BC033068AF471" modified="2020-06-17" version="1">MVLDWVIKLGVKCVSVQYRLPPEYPYPAPIDDCYAGLLWMSTHANELGIDPNNISIASTSAGGGLAAGTSLLARDRGGPALRAQILECPMLDDRNNTFSAKQFATGGTWSQGSNAMAAPSRATDLSGLPPTFISVGSAEIFRDEAFAYASTLWKSGVQAEVYVWAGGFHGFTESASSAAVSIISRDARTAWIQRTLCLDSTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD76</accession>
    <name>A0A6A6QD76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_544377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD76"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="38345" checksum="394FF8CA35780A39" modified="2020-06-17" version="1">MSFPQELLNHPFFATLQASLTPATLTPSDDPDCQICDRPFGELPDVDDYYHRPNLRLLASLPFSIQAPAAAIPTDPVRTPCNHTFCRFCISRWLSEKPGCPNCRTPIPTPGLSHLRITAQAETDADMMMRTFNLSLEQYAHIRRIANLTDREIMTMRLEEMLPDSPCTILDTQTALAELEQVMILVARRSGHPRVRFDGGRDPVHRRSLYPTPVPMAAPISQIAPADAWLARTREADMLYRILATWMRRYGGLSRDVEGSGEAEFGAPITVVAETLFRIVENLMGRRITVDPRVWWKYVRQVLQYWFAWHCCLHEIRDLLGDTEDMDLDFLFSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD83</accession>
    <name>A0A6A6QD83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L22e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_553254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD83"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="131" mass="14922" checksum="0B6F54456F2799AA" modified="2020-06-17" version="1">MAPATAKRASQKTAPKKGTKVTKKFIINASQPANDKIFDVTAFEKFLHDRIKVEGRTGNLGDTIQISQQGDGKIEVIAHQEFSGRYLKYLTKKFLKKQQLRDWLRVVSTSKGVYELRFFNVVNDEADEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDA7</accession>
    <name>A0A6A6QDA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_151963</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDA7"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG01"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025438475" evidence="1">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="240" mass="27130" checksum="0A7D9823853AAE45" modified="2020-06-17" version="1">MGQSLFSLLLVLMFINRQCFVTSMSRENFKLINSHPYLNYLSSPILDSKTFTLYEARQSTLPSPASPPFFPPSRRLRAPFIPGFPHRQRVGTRLYPRRLEACVAHINNMWSLIISMEWLHCISSYFVGRWKGLMTTFSTITSLFTRISAQSSKKAISFNSSCLIMGWHSLLMPAGLTLTDPRHHTSSSRKDGTESKVLSTLATWYHNEPLESMRSYAGVSLYPEEVAGYALAGESTPLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH30</accession>
    <name>A0A6A6QH30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_126852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH30"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15944" checksum="516DF2589E2E2636" modified="2020-06-17" version="1">MASISWPTPDFPKKVEELITEFYSLADSKEDTTPERFAALFAEDGKMYGLAGASTGRADIAAARPKSWNMIASRKHQPVKVYSFKSDYSDVLVMGQISATLTNGNSVSVEYIAQFVLKGDTSATPVIASYKSWADSAPWFKAMGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHC2</accession>
    <name>A0A6A6QHC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHC2"/>
    <dbReference type="OrthoDB" id="3888684at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF1">
        <property type="entry name" value="INHIBITOR I9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025361552" description="Inhibitor I9 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10605" checksum="E91C5EADBA2FBD13" modified="2020-06-17" version="1">MRFAIFSILFALLAALAMAKAPLKSVIVSYPDSTPNSVLDKAKSAIVEAGGIITHEYNIIKAFACNAPTAVLENVQAWGNEYNALVEEDSVVTTFGGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHQ4</accession>
    <name>A0A6A6QHQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHQ4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="164" mass="17968" checksum="8119DFEDA3299D83" modified="2020-06-17" version="1">MRKRVRLQHNPAALGGRSTPGRQGQNCGGAATQPGGELRVSSTQSSTGSMECGRSTPSASAGQHHQRRPVNTISVGRSTPSASRRYSIATSSHVTSSTTPKARTGTDSKARQSQAKHINRKQGLNHNQKNLKHFFFKHPHKASHSMKKRVELPKREEKGLIFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI85</accession>
    <name>A0A6A6QI85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI85"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="411" mass="45828" checksum="9713B8B3D86330B1" modified="2020-06-17" version="1">MAPESMAAMAGQTRQRMQQNEEDRQTRSLGDFAEIEAAMPALTSRFQFSLKDNLSSYLGSKNPFYSYVDPEKHKVWVLDNTAYELNGQAGDWHAEFVAAIFLKGSGKDISKVVADIAEKIGLAGDEEAEKTIAKRLQPFLDAIVPARAVNINFLGNNKLRLGPSGRDGVSSDVITLPRGQYQDGQISTSSAIKADAIDFKTVFASPKGWAVISDIDDTIKKTLTSSAVGILKTTFAEEPEAIAGMPELYKHIVEKLDAPPFFYLSASPYNLYPFLHDFRSAYYPQGTMILRDASWMNLAGLLTNLTQGTQAYKTDRIEKIHSWLPTRKFVCLGDSTQTDPESYGEMYRKFPDGFIGAIYIRKVTGVAEMDESKKNSSERFEKAFKDVPQDVWYVFEDANELYAQVDKLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIB6</accession>
    <name>A0A6A6QIB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_468817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="427368at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
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    </dbReference>
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        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
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        <location>
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            <end position="269"/>
        </location>
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        <location>
            <begin position="422"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="741"/>
            <end position="843"/>
        </location>
    </feature>
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        <location>
            <begin position="712"/>
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        </location>
    </feature>
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        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="853" mass="94635" checksum="ADADB987D03D7323" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIG7</accession>
    <name>A0A6A6QIG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_106782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIG7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="18700" checksum="83D9B4B274B49358" modified="2020-06-17" version="1">MRHCQGECQSALLRQLALQLLCSPPRSPGERDRPESSGRGHSQNDAHKREDMVVEDLWAEQIGRALHRKAWIGNTRLGIAEWHAVARRQDGCWNFAMPGCMWAHDSRSKGVNVWLHVGAAKCADASPDSAPVAGWLGAHRTAVPRAHFDHDSRAVDVDGCKMRAGAAVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIM8</accession>
    <name>A0A6A6QIM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_542630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
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    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="204" mass="21040" checksum="69378D7528111330" modified="2020-06-17" version="1">MSSPTPLPTPPPTFPKIPFLPPELCLHIWALAMPPPRILTLSQSAHGGFKPLKTPAIFHTGSESRIEALRLAASASHHLAPRRPAVLPTSQGLRSRGSAGYAPPQQARPHPAPSGLAAADESRVQHARAAPCQRVVAGAGSGVGSEGGGELPRNSRGAVVVPRAFRGCAPRHGGEVGEDGSGWEGWGAWEGGGCYVCGGRGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIY9</accession>
    <name>A0A6A6QIY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_514960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIY9"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30302" checksum="3F4F7C211641DC73" modified="2020-06-17" version="1">MATDSATYPKTKANTVNRYKHQATYDVETIHSIVNSTPVLHVSFVPDPTTPMPIVLPMIGQMGLFPGSQDEDWKCYLHGYVSSRLMNLADAAVKLGEPGLPLCVAATKVDGFVLTLTPNSHNYNYRSAVLQGFATIVDNADERLWAMQLITNSVVPNRYENTRVPPDNAEMQSTRILKLTITGASGKVREGVPNDERKDMKREDVLDSVWTGVIPVYEKLGEPQIGPYNRVKNIPDHVRSFVDRENALREKYAVDAAHKPAPVKRVKKGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJJ9</accession>
    <name>A0A6A6QJJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_114188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJJ9"/>
    <dbReference type="OrthoDB" id="5400774at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27734" checksum="32119E0E89F334EE" modified="2020-06-17" version="1">MRPIHPNAPGHGHSYSRSHIPVHDEAKAHLIASANHSRIVSIAAQKFRRRENVIARIRLVLRILSLLLCSGILIVLGQAVMVYYKHKDYVVKHNGTPDLRLWPRGLNMKPTLVMLGASVAATVASAVLGVASFSKAVRHITRVGNVVTVLFSTFCIAIWVAAAVYFKIDDFDKTKHYDFLSYTCARRHDQVLDNAVGNLGNLCAQMRASWWGALAESVVEIVSLATVVWAWWVGKRGGKYQKIGVEMLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJR4</accession>
    <name>A0A6A6QJR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_593706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJR4"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="212" mass="22761" checksum="D344D856644CC27D" modified="2020-06-17" version="1">MSTTVLPSVAQSARSTIESIFGFIRAQGSSDYLGEAVSQLEHSLQAADLAQKAGADEETVLATLLHDIGRFIRHTPAADALKGLDGTRMRAAEHDVLGEAYLRSVGFSDKVAQLVGAHVVAKKYLTAVDETYFDRLSSASKESLIGQGGKFTPEEAKAAEKDPLLQLKLAVRRWDDQAKVAGAKTPDLESYNDLAVKCLIGLWSPCDGFPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK62</accession>
    <name>A0A6A6QK62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_465933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QK62"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="347" mass="37521" checksum="48B905EBD6EBD354" modified="2020-06-17" version="1">MASELLLITGATGFIGIKILGLALEAGYHVRAPVRSEAKAHSLRSNKYIASFAADARLETPVIEDITIDGAFDDALKGVTYVMQVHARCLAPSEYAAQLVEPARKGTTSLLYSALKTPSIKRVVITSSVSVVLEWKYWFRESTDKVYTAADRAPFETEYPDGEFQAYSASKIAALAATEAFVEMEKPRFEVVTVLPAFVFGRNEAAEELGSLMHGSNTIGFGQVLGNKMNIGPAATCHVDDVAAVHLKAATDLSIPGNRAYMISTGPPGEIKIADALDVVKKFFPERVADGTLPCTGFHDSQRVLCDASETEKVFGIKFKSYEEGIKDFTAQYLEFVDASLGAKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKD1</accession>
    <name>A0A6A6QKD1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_514854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKD1"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025531573" description="Late sexual development protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38032" checksum="1F46CEF6918E0A34" modified="2020-06-17" version="1">MRSVFSMAAVAGMALSSFVSAAPIESRDSPAFPLADGFPNPSHDQILAIQQRAGGTLPNAKPGPPVSQDGLISLRLIAFNELFEVAFFTELLTNLTNKVPGYDLGNGHQFILEAIEAVLAQEELHALNANGGLVGNHVDPILPCKYSFPVSNFKDAIALAATFTDVVLGTLQDVQFKFAASGDIGNVRGIGSVVGQEGEQEGFYRLLQTKVPSALPFLTTSVRDFAFTAIQGFVVPGSCPNIDTIKLNTFQPLNILSTLSAKSQTIEFTFDATKAGTDEYSTLKLVYINQQNNPILETITVIERDGNMVKASAYFPYSEFEMNGLTIAAIAKGNNFANADEVAADAIFGPGLIEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKF5</accession>
    <name>A0A6A6QKF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKF5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="156" mass="17222" checksum="7244BD40B83E3167" modified="2020-06-17" version="1">MAIGRRDRIRTTLALLLTIGILGVATVAVLGALHFFNKDAHSHISCHGLLLTNCSGLSMNCSSLFPIYNSSLPIINNSLPINNNSLPKACTYSLSTDYAYWLPANCTYSNRTKYAYLLPVDREFWLPTNCTYSLSSKYSGLAATFKHIGRVEPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKR4</accession>
    <name>A0A6A6QKR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_92941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKR4"/>
    <dbReference type="OrthoDB" id="10491660at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="42003" checksum="A1FA2D65DF3C323A" modified="2020-06-17" version="1">MPLPINPPGTPWTRMLPEPVPIRNAPRRQQAGRLTGLFRDREQIFQGLLSHTRREFTTNQTPRELGGDEGFRPDKENKGFRPPAWLVPEDSERPWEMGPLVLTLLREDGVTPATVDIDAGESTTHGPEVESSAECDLEYSNSISHAEVEVTELEEAYIELGVMYHQTTDAARNTSLSREQRRTLSTAFSGQPRSAHPLFEPLRRAQSLYNEAHHAHHEADMSEEHRARLGDLLTRGSQEVQVFREEIIALHQLVTSIRDADAALAFGGRDPLLHRRAMMARHRPDEYLADPRIRAWVMALPETARQLELGVPLAHVIIRVFEPGDGPAVDDVHVWRGQDSPPIPRSHESTSEDSESDTHESMESDSDDSMDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLF9</accession>
    <name>A0A6A6QLF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin remodeling factor mit1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_528502</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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</entry>
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    <accession>A0A6A6QLW5</accession>
    <name>A0A6A6QLW5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BU16DRAFT_619710</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493375.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="222" mass="24305" checksum="CC6DB6EE15D6DC3A" modified="2020-06-17" version="1">MQGGRGQKRRGGALAVDGLAWDGWFDSLEIARAVGNNSSVRGKCAGNSMDATLDSRSIEPETKQSPSARPAAGEGGIPALDLEASIYLDWSVQKVGQSETHHPLDGGTPGTHNIHSVDTTIWEDNFKIYGVIKDTTLYFMKNGIFINWLQFFALLNPDKTSGTVLTGYNRLRQNGTPRPRIVPWKNSTPPLPTTKYTAIAPMSEPAFPPSPHTRWKARRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNE0</accession>
    <name>A0A6A6QNE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_583682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNE0"/>
    <dbReference type="OrthoDB" id="4937259at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="595" mass="68240" checksum="EAC1833C0A0CA27C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNZ2</accession>
    <name>A0A6A6QNZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_64468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNZ2"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="175"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="390" mass="42853" checksum="2CB83BB3001DD6F8" modified="2020-06-17" version="1">MSFSHIPILPLSAARDEATKPRFLADLRDALLNVGFLYLSETGLPAGLVADVVRECRDFFETLSLEEKEAIEMKNEKSFLGWSRVDNETTAHNPDHREQLDLSTPQPIPSPTAPLYHNLLGPNQWPSPTHLPAFRPVFEDYMRRMASISTFFTSLIAEAIGLPATSFDGFFDADQQHKLKIVKYPEVAIPPLGPSATAEEKRNEDIARQGVGPHKDSMLTSYLLQASPQAGLQAQNARGEWVDCPPIDGTLVVAIGQGMEALTDGVCASTTHRVLSPREGEGPRYSVPFFQGVSYDAQFEAMDVPSAVLKLRDEARKGRKDDVEFTFVKGRWGHLGEATLMNRIKSHPDVGERWVGANLGWICRTTIANGNTVSRATGPDPRATGSRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP27</accession>
    <name>A0A6A6QP27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_562833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP27"/>
    <dbReference type="OrthoDB" id="3944243at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="291"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="781" mass="90087" checksum="B03978F61AB6A3B7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPI4</accession>
    <name>A0A6A6QPI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_528101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRM3"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="115" mass="11809" checksum="6A40B6E904B12743" modified="2020-06-17" version="1">MCTTTNPETATAYAALILADAEVAITAEKMMTLIRAAGVQDVEPIWGSLFAKALEGRDVKELMLRVPAGGGEGGGGDGGKDEGEEEGEGVEEDVAVEGSRDDDSEDGGGIFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS07</accession>
    <name>A0A6A6QS07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_47745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS07"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="127" mass="13891" checksum="7B093A1E3FE1FCAF" modified="2020-06-17" version="1">MFVCAMEVISLRCLSLFFLARRASKPTRSSVITVRWMSEVTSVEFCSSFSAFHSQARGRKRPRTGRGRGHGANAMGNGDSENPSLSALLSNLRSLSLLLCQTCGRPLVSDVLSISSLRPQPAIHHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSG2</accession>
    <name>A0A6A6QSG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_527696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSG2"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="534"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="594"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="663"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="876"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="987"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117539" checksum="6AAC2C0F53D6E44D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSG4</accession>
    <name>A0A6A6QSG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_549974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSG4"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF82">
        <property type="entry name" value="OXIDOREDUCTASE SADH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="304" mass="32888" checksum="6402493CE0DD0A67" modified="2020-06-17" version="1">MDDKIPEIQSSDPHLGARFTSQTHHDTYSAIDPTSVDLLGQAVFITGASRGIGSAIAVAFAKAGASFIGLGARGSLSNTEEAVLAAAKQIGKPQPIIVAVNLDVTDTESMIQAAAKIDAHFRKLDILVNNAGWLETGAPIHESDPMSWWQSFEVNVKGVYLSTRAFMPLLLKTPPSSSSRQIINLTSIGALMVIPGMSAYNTAKLAICRFTEYTAVEYAHQGVIAISLHPGGVATDMGLSLPGAMHTSLTDTPELAADTVVWLMKERREWLNGRYVSCQWDLPELEAKKKEIEERNLLKNKMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSW4</accession>
    <name>A0A6A6QSW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_394235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSW4"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="289" mass="30989" checksum="D2EB2B2910148A5A" modified="2020-06-17" version="1">MNDYPSFTLTWHRTSYSSISPTTNPTLSFASKNILITGGGTGGGLAMARSFALAGAAHIGLLGRRIPVLSTAAAALSTEFPGTQFHTYSADVANELAVDTAFAAFEKDAGKIDVGIHNAGFQPALAPLSEMSPDDFKAGIDTNVMGSLYFIRAFLRAAAAEAVLIYVSSAVMHLPTMANWAGYAVSKEAATKLFMHVVAENKNVRVHAIHPGLLETDMSAMNIPKGSGVVFDDMSLAGDFAVWISSPEAKFLNGTFVWSNWDVEEMKERAEEIEKGYLLRMGLVGWDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSY4</accession>
    <name>A0A6A6QSY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucan endo-1,3-beta-D-glucosidase 1</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Daughter specific expression protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_510367</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSY4"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000008">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025539482" description="Glucan endo-1,3-beta-D-glucosidase 1" evidence="17">
        <location>
            <begin position="19"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="18">
        <location>
            <begin position="137"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="19">
        <location>
            <begin position="469"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2495521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="830" mass="88914" checksum="A1DB94535A4DBB44" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTJ4</accession>
    <name>A0A6A6QTJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_526374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2495828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="507" mass="57491" checksum="6FF4B7F3189A3679" modified="2020-06-17" version="1">MALLSNESGRIPHIKTAVASILALYLFGFIVYRRYFHPLAKYPGPFWNSVSGLPAAFSLLRGRFPFDNKSYHEKYGPVFRLGPNELTFSSAQSMHDVYGFRQGHQNMKKSPLHTGPVKVGSTTTLQYVPDDADHGRQRRALSHSFSQQALMDQEPIVQDYMSKVVSNMRKLARKEETFNICDWFNYFTFDTMGDLAFGQSFGCLDRGEYQEWVHMLFQTVKDGMMIQATRRIAGTGTWLQAFLQSRIKGMGKANAYHVEHTREKVLKRLEAKEVDHRDFIWYILRQQEKFPLKQDEIIANSGLFIVAGSETTGTALSGLIARLIWKPSCYEKLTTEIREAFSTEDAITFKAVFDLPYLNACIEETLRIHPPVPAGPPRSVPPGGDTIDGFWVPGGTTVSVGQWSACHDPANFRNPDEFVPERWIGTAYDSDVKKAAAPFSLGPRNCIGKGLAYMEMRIMLARLFWNFDVVSVDGAPLWNPEGGMKYKKTFMVWEKSVIMVKVVDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU32</accession>
    <name>A0A6A6QU32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_582269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU32"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="201" mass="21953" checksum="EF7BBDCC3ED669B8" modified="2020-06-17" version="1">MPTVPTTPSSSKSGITTSDTGERHIPSSTRPDGSVRKEIRVRPGYRPPEDVEVYKNRTAEAWKTRGSGGVPGAEPLVKKAAPASGAVNKNAKRREARKRAAADGNVEEGSTNGDAPKSADGKGPQVEELEPPTEVDLEVEKEKEAKKLMKKLRQARELKDKKEKGDTLLPEQFEKVIKINELIRMLDNLGFDGEGVRKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUG2</accession>
    <name>A0A6A6QUG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_561840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUG2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="112" mass="12116" checksum="A8AA350589EE9EBE" modified="2020-06-17" version="1">MVRRKSPHIAYLYDILQPSLLLFSFVPRGGHTRFIIRTPGERVTMPAPRRKGNHAILTTSPAGRETAGTQLLNGGNRYAKAVTNAPCSPPHGTSRLSGGEPGSPRFRVSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUH0</accession>
    <name>A0A6A6QUH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_368160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUH0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="280"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2496158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="733" mass="82898" checksum="87A25EE54FF1149B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV21</accession>
    <name>A0A6A6QV21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_508801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV21"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="626" mass="67549" checksum="6EBE658895EBC511" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV97</accession>
    <name>A0A6A6QV97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_526813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV97"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="55" mass="5767" checksum="13FBC40E9EA1E48F" modified="2020-06-17" version="1">MLGSLALTSSSSSFITLTSSLIFQFPFTGLSLLTIQSDYVVSGTYIVISALAMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVU7</accession>
    <name>A0A6A6QVU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_609075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVU7"/>
    <dbReference type="OrthoDB" id="72726at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45185" checksum="2EB29A41E4BBB1E2" modified="2020-06-17" version="1">MGRSKKKSQERSKAKKTHDVPEKPQLPPADTQSSSRLMQLPGELRNQIYKHLFSSTRLTYGDRRTGRISSVKMKSALNSLAILRTCRQVHREAATLWPGLVLFNFEDVDALLDRLSPLPAETLSKIRYVRTRGHTLMLLPVGEEYNIYYRLAESLKLLPGLRLDTLTVLAPAHGTIAYDTLDGLINRGNGWKELHFITPNSEMLGFAKVEMFMMDPYWRKPQPSTWESALLKRDSIIGSTKATVTIYRSTQADASGSIINPHTRKLFTQPVPRNQDHPDFGVAADDALLAEKKELLVIAKRGQGADIAEQTEPPFGTNDIREWAYGMTWAEIRRQCIDLHHDDEDFPSSDEDELLLSDEDEESDEDDEDSSSMWKPKDNAQIDSYIHVDDVEWDFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVV0</accession>
    <name>A0A6A6QVV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">BU16DRAFT_526824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVV0"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2496326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="245" mass="26912" checksum="C4395A35E60F2D6C" modified="2020-06-17" version="1">MGSLFKLCQTPHPISRPHASQNLVTLYGLNDIATSVQRIKPGTANEKNTLRKTYLGHVKNLQLAGKNKPYNNPNEDFRDLLSWPVEEWHNQKEHGKRISDGLGDEVLDLLDRALQMAPGKLPHEQAEKWKGIVAPDETVKPKSIADMPGKRPLQPAPAGRNPAAMSPGLKSARPERSGVKRRYNETSFVGYGEGYADDDVADSTGGEDDGRGSSKKKRRKEFSAASPLGMNDRGMSGMGMIGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW39</accession>
    <name>A0A6A6QW39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_525792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW39"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="187"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2496635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="36524" checksum="E4348CB37FBE70F8" modified="2020-06-17" version="1">MVFGEITTKAHLDYQKIIRGAIKDIGYDHSEKGFDYKTCNVLVAIEQQSPDIAQGLHYDEQLEKLGAGDQGIMFGYATDETPELLPLTLQLAHKLNLAMKEARNDGSLPWLRPDTKTQVTVEYKHDGGAVIPLRVDTVVVSAQHSEDISTEQLRKEILDKIVKKVIPAKYLDDKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWIAKSLVNAGLARRALVQLSYAIGVSEPLSIFVETYGTSDHSSKQLVEIILKNFDLRPGVIVQELNLTNPIYRRTAQNGHFSDQTFEWEKPKTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWV7</accession>
    <name>A0A6A6QWV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_537795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWV7"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="430" mass="48035" checksum="5A85427D2FC4F14C" modified="2020-06-17" version="1">MANAADKARFFLEQSVPELRELEVKKIFTRDEITSLAKKRSGFEHAINSRGSHASDYARYAEYEMNLEALRKHRVKRLGVKVPGFTGQKRIFFVLQRGTRKFPADIGLWMQYIEFARKEKAFKKLNDILASLLRLHPTKPELWIYAARYAVDTQADYTNARSYMQRGLRFCKHSKVMWIQWAKLEMNYIAKIATRRKILGLDADPTTKTQDQDDTEDMILLPSLTAEDINPSLATTDAVDQTALQNLASSPALSGAIPLAVFDAAMSEFKDNTSFAEEFFTMFNDFDASTVACLRKILSHVLDHLRQTSPNSAAAAMCEFRAPLIGVSQTSPAFASALGQALDHLNTSLGALPERKQPLLKSAIQWALPLVRSGDITDPGIKKVLSSSLRKFCRILGEETPKALAELTTALQKEGRVDDAAFLANVAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWW4</accession>
    <name>A0A6A6QWW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_391310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWW4"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="18565" checksum="2E64BEE8B969212E" modified="2020-06-17" version="1">MAPEHTVNPIRRLVPILSRLLAQQLDVPPPEAAVLDYLAELTTEERAELQELLAHPDRPGFIITPDEISLIDDNKQLMLLFFVSDVSKTFKSTTLTENMEAEMDGNEAVEGDGPSTQGPSAGETTNNGSVSGDEMEMDEGSRKPPTLAAPAHITGSTDGPLKRKRELEDDA</sequence>
</entry>
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="279" mass="31823" checksum="462461900A8A77C9" modified="2020-06-17" version="1">MQSQTQEPPQKRRKLEHDAEVFHNVAEETAEKAGAESLSFFSLPGEIRNKIYDNIFQDKDYKIHLPQFVLGSNTHRHRPLPQLTSPDGIFVPHHVRDYYALLAVNRQMRKEVASLIFSNHLHLSIETPSGLKDVAQNVGNLGLSYIRHLALDWYTSGYLFFNLKKEAGLSISSLLQRFTQLKTVVISVDCQFTPRFTKAAAFVEDNGLQELRAAGIEVSILGRWDPYLIEGEGWGQSMFETFTEWHAEVCEIRRRDPGCPPPQASQKKRKAERANLSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1F6</accession>
    <name>A0A6A6R1F6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
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            <end position="216"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAF2498212.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="576" mass="63442" checksum="581030F01AE4A880" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
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                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 269.34</strain>
        </source>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="11">Bromodomain-containing protein</fullName>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2498047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R497_9PEZI</name>
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            <fullName evidence="3">DUF6987 domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
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    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="29"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2500378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="543" mass="61649" checksum="822A748BE145DAA7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R797</accession>
    <name>A0A6A6R797_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_558046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R797"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="68" mass="7693" checksum="768B6F7DBC3668BA" modified="2020-06-17" version="1">MDAAKVPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVRENDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R870</accession>
    <name>A0A6A6R870_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_546405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R870"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="474" mass="52371" checksum="E8BBE2434F5A6279" modified="2020-06-17" version="1">MAYDGAGISAPSEIEWTPSSWRTKPIKQDVTYDSASALTAALTKLESLPPIVTPTEIIKLKKSLHDAALGKAFLLQGGDCAELFSYCSDDPIDSKIKLLLQMSLVLIWGANKPVVRIARMAGQYAKPRSSPMETIDGVQMPSFRGDILNGFDIADRTPNPERLVSAYFHSATTLNYTRAQLSSGVADLHNPMDWGLGHVRDKSLQSKYQRIVTSISDSLRFMRTIGADTAGQLQTVDLYTSHEGLVLEYEQCLTRRLRHPANYDSSITSADRKGWYNTSAHFLWIGDRTRQIDGAHVEYFRGLENPIGIKVGPSMKNAELVQLLDIVNPRKEVGKITLITRYGEDKVESMLGPHIEAVKASGHVVVWQCDPMHGNTRSTPSGIKTRHFSSIFSELSSALKIHQQHGSFLGGMHLELTGDAVTECVGGSEGLNEEDLSLNYTTYCDPRLNEKQALELAFLVAGHYRGESVEMSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8E0</accession>
    <name>A0A6A6R8E0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_533716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8E0"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2500978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="40943" checksum="335BF7361B8F1910" modified="2020-06-17" version="1">MKVPCSIPSPVSSEAPPPTSLPSASASSPSPSSSNVPSATSTSSSIDSSVYSRSAISTSSSISSSVYSSSETSPFGVVASPSSSSFSTCYIKGGKKSCENEPSPTPNLPPGSISPDGTCGGRRGYTCKGSPFGRCCSRDGHCGNNDFACGELCQPRFGACEPPRPVTPPSNPISPDGTCGEHRGFTCKGSKFGRCCGPDGRCGNTPFACDRGCQSDYGFCERPHPPVITPKPTPVSYSKPCYISGKTVTVTEWPEDNGEGPDEGHRPPPRPTHHRPTLTTISAIETSSLCFSPYTWSFASDIPSGITGVPPTPTAGSGGGYCVGPVTTRSTRAHVRTSSLCFPPYTWSFTTNIPTGITGMPTTPTAESGGGYCVEPDEESEWDGRPDDGPERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8H7</accession>
    <name>A0A6A6R8H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain type dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_535414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8H7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="253" mass="26448" checksum="183C1C83BB9C407A" modified="2020-06-17" version="1">MQHQTMPGKVAVISGSCSGIGAAIAKELSSRGVHVVINYPIPSLVTQAESVVSSLPTSGIAVEADISTTTGPAHLIAAAVSVYGKIDILVNNAALAINLPLEEQTLSHWDHLVNLNGRGPFLLTQAALPQLSRGSRIINIVSASSRGAPPGQTIYAGTKGMLDSFTRCWAKELPPKYGCTVNTVSPGPTRTAGFADAGEEAMRLLQPILNQTPVGSRMAEPEEIAYAVAILCEDRASWINGVHLHANGGLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8K5</accession>
    <name>A0A6A6R8K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_598664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8K5"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="116" mass="13273" checksum="BAA191671FC234B4" modified="2020-06-17" version="1" fragment="single">IPTSQYSLESQSFIAAWIIQVWGTTFVRLSILDFFAQVFRVSRFALLVYIVEGLAIAYLVGYTITFFAICRPMRYNWELSPQIAQHCGSLDLKFLLSSIFNLTLDCLILVLPLPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8L3</accession>
    <name>A0A6A6R8L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="120" mass="12455" checksum="DCE364D3EA0384DC" modified="2020-06-17" version="1">MIPIADNATVVTSVAITPTEAIAPANNFTAVPTTTAPEIMPVRIEEAKCSPSTLCVDAIMYCGEATMRYGGCYDVCTATITTPSCSVTASVSSTTYTSKATKKSKAVKAVCTAGRFCPAW</sequence>
</entry>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9R9"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="406" mass="45877" checksum="B12E8732FEB036C6" modified="2020-06-17" version="1">MPTPVPFKIAVPEEKLRILHQKLSLTELPDEVPLKKPRSRGAPLRDVKNLVDYWLHSFDWRAQESKLNQFPQFTTDIDVDRFGTYNVHFIHQRSAVPNAIPLIFLHGWPGSFIEVTKILPELIQGGPNFPAFHVVAPSLIDYGFSQGNTKEGFNLDQHAEAYHKLMLSLGYSEYVAQGGDIGNFLTRFLALKYPESCKAHHTNMPTPNPPDPSKHADLIAKIEAEGGLSEEDRNRLASTQEHQADGMGYSTEHMTRPQTIGYSLTDSPVGLLSWIYEKLVDWAADYPWTADEVLTWVSIYRFSRAGSAAPQRIYYDMMHREPMSLVDVTAQYIDVPLGTSHFKKDLFRLPSRWDATLGPIAFQAEHDKGGHFAAWECPKELVKDLRDMFGKESPIHGCVTGQSGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAQ8</accession>
    <name>A0A6A6RAQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_251974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAQ8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21062" checksum="313487AC21E4C2FA" modified="2020-06-17" version="1">MPDDTSLSVEVFESVVSPIFEGSEALADADIDTISDLLILRGKEEWALRPRTYAVLRMMNRLDAMGTFIHYRLNDFNIPYTVDRLLSVFSDYSSRESFVEKQTLVVTKESGKAYDLERNRGRHRHFAYDADSHFVVIRRLGRGGFGEVDCVRSKLSLREYAVRSLVLGQATVRKLTLDSGKECTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBE6</accession>
    <name>A0A6A6RBE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBE6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="175" mass="18603" checksum="6B2314D1DB3CAA04" modified="2020-06-17" version="1">MSAPPRPSAEAPPFAASQTGLLPSSRRPGAADASSTNTTSNVIPSSLGGDDESPQRPPPERWTASFCSPEQIDDLGKIAFQRFAQTGIEHGTSRSTTSMPLITSDHAQPPMLHPQPLRRQSQHSVFAKAVLLSQTLVHSIERGHDFRGESGGAVRTSDKTPATEPTSQPVTTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBV1</accession>
    <name>A0A6A6RBV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_611996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBV1"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="102"/>
            <end position="192"/>
        </location>
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            <begin position="211"/>
            <end position="290"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="469" mass="51662" checksum="57641D45D8B405F7" modified="2020-06-17" version="1">MSDDTATAAAATAPPQEEQVKAAESVDEPTPEKATTPAETKLPSTDSTPEKKTAEDKVEAEKPKDEKVHGDKNSNGKREFNGNREGRSYNNRQANVKTKFEDLPESKDPEEIRKQAEFYFSDSNLPGDKYLYELVGGPENKAVPISIIASFKRMQRFKPFSAVVAALEDSKILEVVNGDQVKRKDPIAITASYDLDPRAQLMAENDVAQPRSIYAKGFGEEGSTTQFDIEALFEPFGPIKAVRLRRTRDKEFKGSVFVEFADESLMEAFLALETKPKWNGEDLKIMTKKEYCLAKLKDIDEGRVQPNVNKPSYYKKPQNDGDWKSGRKDFQRSGEFRGRGGRGGRGGRGRGRGGERRGGRDGDRRDGRDGRDGRDGRNGRRDRSRSPRGPKLDAQGIPIVQVLTPPISKPADSAPNSAGKKASPVPEKKAEAGADAAATSTKKRSREDDAPEAQSPQEKKAKTEVSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCT3</accession>
    <name>A0A6A6RCT3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_554334</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54910" checksum="9C31C36B0B93316D" modified="2020-06-17" version="1">MNRAAKAQRVRRAPQQDTPRPARMTASTVAPGFVPGSLALYEGRTMRTRGFERAVRQTFRFLDLPAEIRLMVYSHVVSFNGVSRYLIEKAKYLYSGIGALPVLSTTTPGLFLVCRQIAAELCDEIRKIPLVLTNMYGIEDLTKVIAPGILRNLQHVTISIHQFDEDQCIVVNMRSLERIGEELSRIWEFGGNSLKKLTIRVDDDRISTHFKLCPPTECYLRDEIDIALDAFSTLRNIKDVTFEGILSDFGHAAYIASTMEIPTNYRFMELPQSIRKQIYEYALDYDESMDVMDKVTKQKVILRSHARRSRNAAKIPTEKIRHVYSPAILRLNKTIRAEAMEVLNEKGLTISAAPPKKHSITDFISATTLQNVRKLTLKICEETLGHWDEWRKVKVDLGKIFRKGNSLESVKIYVIYMEGSHQISAVFRKLFMNDIKGQFALGDGVMIDHYLHGAVKSPNTREQSKKRPREDEGPKTMDHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6RDD7_9PEZI</name>
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            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
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        <name evidence="1" type="ORF">BU16DRAFT_522420</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
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                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14948" checksum="8B42DD7B6AFFE701" modified="2020-06-17" version="1">MDNAAIIAARAPSCLRHFHPKSLNYPPQDNAAYKRNLDSMHSVFANFSLTVTDCVEDVAARKISMWLEARGDTAAGEYVNEYVWNMEFDEAGEKIVGWREFVDVGMARDFFPRLMVEVRKRREEEAAAEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="179" mass="19420" checksum="83B6BC48FD08359D" modified="2020-06-17" version="1">MSELQGPATPKPRTPKPAPTVKHAKSKQLVQSNFSTPKPPPLCAPLLATPNRPYQAVNIATLLSNPNTEQTSRSAISSGFWRTGCGETHSNSRARRAIRRDGSGLAGYSVSFSFRLTFAGSLDIQWLEGASGAKIKYPRGKVNMCLAQDWIRLRFGPNNEKRAVATPTSPHISFSGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REC9</accession>
    <name>A0A6A6REC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stem cell self-renewal protein Piwi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_422901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="281" mass="30907" checksum="1DA67995F6A19351" modified="2020-06-17" version="1" fragment="single">DQYFSNLALKFNIKGRGINHTLRNEFSLLMGGANRALDTIVLGADVSHPPGNGPDGSPSIAAVVGSVDEHFMTYLGSMRLQAGRTEIISDMKDMVEERLLAWKAKNKVLPKRILFYRDGVSEGQYLEVISKEINAVTKAYQAAAGTDAAKPIITFLIVGKRHHTRFYPNQLEGTVDSTSRNPPRESNGNPRPGLVVDQVVTQPGKHNFYLQAHAAIKGTARPAHYQVLQNDMGLAHAQLQSLTHSLCYALGRATKGISYAAPAYLAHLLCDRGRAYLREWN</sequence>
</entry>
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    <accession>A0A6A6REK4</accession>
    <name>A0A6A6REK4_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_34269</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
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            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="209" mass="23402" checksum="B175637A9C444C36" modified="2020-06-17" version="1">MAPPARGRGYRGRRWPNRTPQQPQQRRRPVEVKGRLEAAGRVAGQGPCRASCRRRCFSERACGRRPCNRTQLNRVAEGRSTWLADSRRIREHRVERGAHAAKMQASCSERLPDEQLHTECRRVENHGRSKSRSAEATNQRRVRATSRLARRGKQQSEGELASVRSSQAARGAAVEGLVLQRAGSGLVRAEMTRASRARQHDADKRGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REW7</accession>
    <name>A0A6A6REW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_521737</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
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        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="260"/>
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        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2503121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="372" mass="41905" checksum="79FC7770826FAA2C" modified="2020-06-17" version="1">MLARRLTPRVRNAVPSSQPAVVVSRSFSALPAAQGPVRAPALADITPDAAPKFDARQKEFRESLVAAQRQKEQQLSQSPSKSHSSLSASSTNGGPPLVGDTLGSLTASHAEEARAREAQEGAKKKPGALTSLIYGTPEGRELDKDIERSFSQVLARGKYVHSIVFHDVKPDKVDEYTELVGKWYPRMADMPENKVHLVGSWRTEVGDCDTFVHIWEYQRYHGYHASLNAIQHHPEFPEFDAKLKTLINSKRTSLMQEFSFWPTTSPRQLGGLFELRSYTLHPGNLLEWETHWRKGLKARREVMEGVGAWFVQVGELNTVHHLWQFADLEERKVRREQSWGVEGWGETVHKTVPLIQSMKSRILIPCSWSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REX8</accession>
    <name>A0A6A6REX8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">Pyruvate kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REX8"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="56" mass="6215" checksum="E009CB99057849B0" modified="2020-06-17" version="1">MAAVSASLEQNAGAILVLTTSENTIRLVSKYCPVYPIMEKWTRIKAIKEEFEGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFM7</accession>
    <name>A0A6A6RFM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_499463</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFM7"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2503284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="593" mass="66904" checksum="ABE6381C187CC3BE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFU1</accession>
    <name>A0A6A6RFU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFU1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="160" mass="17742" checksum="E5B2D788D18A4EAD" modified="2020-06-17" version="1">MPDSWEDLKKKWSTQPEPGAIFAWLYGGYPKEGLNFCTKVSESGRTLLAIDLDGHINSKTAPVIDKGDNNTFNITADNGKLTCVAAGDWFKFVPSDELSGESYDFHTGGKLNWKDGHLSSFYSVEMGGSACYWNSEGYVNRKGDGNKLGARWRDTKRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGE3</accession>
    <name>A0A6A6RGE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SWIRM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_545988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGE3"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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            <dbReference type="EMBL" id="KAF2488420.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 269.34</strain>
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        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="639" mass="73494" checksum="51B92492301CA051" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8D1</accession>
    <name>A0A6A6Q8D1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2488708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1638493at2759"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41339" checksum="0A1D43876FBF5D5C" modified="2020-06-17" version="1">MLFEDLATELVSHVFLSCSSVADVLALSSTCHRFRQIYSSSQKLTILEHAAETQFGPLKDLTQLLTHNASQPAHIPRFVPFSIALLKQIAHSGRVAEKWCDIYPFKKWKSNFEHRRLLTTNERYRVRRALYRLWLYTHAFHNRAFPRDTRVMKLTIQKRAGLLHNWSTAELAEIADVHAVLREVIHSNVCPSNGTIARKFKKRFPENESQQLLFNIHLNYPPPNNASSLFQSQYHSSPNVLSNHFHSTSAFNSRYGLAKFMPTPYHEPGAEGWGDDIPHYYVVEDMLKLDPEQIMWLKENAPLKGQVEMFVKRLGDWFENNGETWGQTLEWVLEERGEDVGEILGAVADGDLGIAIFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8H3</accession>
    <name>A0A6A6Q8H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_230196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8H3"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26696" checksum="A65B241D91325F6F" modified="2020-06-17" version="1">MAPTPGLLCVRSRITSEALSDAAFNDWYTNHHLPDFISSGVADLALRYKNADASKMWQYLALYRVPDIGFQSDPEKIKAIRMNHETLPNGGNITDFTELKANMYLPIQSFEGTNPNTERAKTLFIAEIEPEQGTDEEALGDFYEKQHFHMLSMHHQYHRSNRFKTADGSKPPFAALHEFDNADLDQRMRTTMNATKWAKNIEGNAQMLEISCWELITEQGKIGENLIVDAALRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9D7</accession>
    <name>A0A6A6Q9D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_567970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9D7"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54034" checksum="5DDDC901A4BB6B04" modified="2020-06-17" version="1">MAVQPVIVSFTFVNQTGSSVVAKPDEEDLAIIKSHAMRAVHRQRRASPRKPTRTHKLAAPLATDWEDLALCKFFGDFVFPKENAGGNAFRYLDFLPSIYERDAKQSHLTDAVLAVALIHFANQKRVEGLNMRARRSYARSLNLVNRSLANPIEKGSDEVLATLCLLAKYEIISGDETGLWRSHEKGQAALINHRGKAQLQTEAGLGLFRLIWIRQQLNCIAQSATPPERPTFNWDLAFPSPHLKQLMLLVSRLVLVRSQAHELFADGSEAIAEEKTTAELQWAHEVQSIDEDMLSFRQSLPPELHHWSAASCVVIPEEARRAREAAEYLPMHLNIFYNLHHASIWHIYTYCQIYLLQSMIQHTSPLCNCGDDMPQQVEESSSMFTTTVIPSICLHLRLQQAIDDVCASVPFLLGWSDDARFLNTAGRGRGIACHYIIWVLAAALSVREVLVPEAQREWIRARLIEVGFLHGIRHALVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QA38</accession>
    <name>A0A6A6QA38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_472031</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QA38"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48373" checksum="85F66FCE9321C736" modified="2020-06-17" version="1">MRAVSLQAAHTDVLKPSVKELFNPLFLNTNTPWSAFICGSQGSGKSHTLGCMLEGCLSNNSKIGKLPHPLAGMVFHYTKSAGAPCEAAGVHSGNVKTTVLCSPTNLAAMKSLYRAQPGASAHLTVEPLYLESSHLNIQRMERLMAFSDNEKDPPLYMQTVRKILRGMAARINAGLGEFDYDDFSKLIDDEDFDNKQKGPLRLRLDILESFMAPSPKPKKTTGPSGGSKKGQTGSVPPPPPPKATTMATKNIFVGSPGTLTVIDLTDPFLDTDTACRLFEICLSEFLDKTDCGKVVALDEAHNYMSTSAPGADIFTEKLLHTIREQRHNGARTIISTQEPTISSKLLDLCSMTFVHRFTSPAWFATIKAHIGGTSAAAIGSEGQNRMFEEIMALKLGESLLFSPTAAIRVENDEVETMKGGRVKFKTRPRISHDAGTSVLASNSRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAU2</accession>
    <name>A0A6A6QAU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_597006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10003767at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APH"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="101"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="489" mass="54023" checksum="DDA712268DEA26C0" modified="2020-06-17" version="1">MADSNDSTVGFRWNVFSTIPEGMALRTRAEAALGDTNWDALLEYASKLRDGTECKLLTDIGMGANHMIRVIEFDDGKRWVARVHMPYSMYDGSIKMVWDDAKETFDNEVVILNLIRESSNIPVPAIYAHETADTVGVQAPFILMECVEGNVGTDIFDDKTFEAFPDERKDTLFDSVAEVHVGLSTVLLPKIGTVIGRNEDGTYIQGPIYPIGGPFDTATEFFQAWAKNMPFCNLAHMPRLLAKGGRSAEIPASIEAFRAAIQELASKISVCDKGPFPIWHNDCGNNNIIMDDNFAVLGVIDWEMAYAAPWEVFGDYPRFIESVPRAMDSPQFWDESGNPATARGRMDAAHQKQYLAAVIRAEAKRGLTLDNHLHLLSAALQDTKRHAVAKAMWLFDDGKLACYHLVTEEFAQSLLEEPKVSGVSQDVTTASSSVTNPSPTKKKRKPLGAIVNEQPTFARDIKVQETTKSKTPEPTASYSKENTPSSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBC7</accession>
    <name>A0A6A6QBC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_566880</name>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBC7"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="17059" checksum="26067E1447813434" modified="2020-06-17" version="1">MCIAEYYRILNPSYCHDRPNHGHFVRITFCSIKMRNNLDIGCTDPTSLWILLEDVTQNEANSYYNFDFPQGDALANGCNNYDPEVFKNTRFEKAQYNTHGEKETNRAMVRPYCPLCSAAKAAAAKAVADAAAEDAAAEDAAAWSDGEDTAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBD4</accession>
    <name>A0A6A6QBD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_212545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBD4"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2488777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="696" mass="76525" checksum="41A0DA19782662AC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBK5</accession>
    <name>A0A6A6QBK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_622910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBK5"/>
    <dbReference type="OrthoDB" id="3772738at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8817" checksum="1E7CD642D6601CE9" modified="2020-06-17" version="1">MKTNNYQPEPCNDDADARASNFPTLLDSFFSPWELAKKKYSYIWQCCACGCASINISSATCPSCGAARCAYCQTTKVQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBK7</accession>
    <name>A0A6A6QBK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_531895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBK7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="170" mass="19243" checksum="3C83983260D6C77F" modified="2020-06-17" version="1">MKAREQASSQLSSGYISLAQANYHNRTRFGQDYYDERMQASRHVSIKMNGEVPSFTVSKVELQENASKEESERPDTPEQPLKNEPQAETSEPPEKTLDVPFIEEKHVYANSLDPIRWFGILVPPALRSAQSSFVSTVDGPIPRLASLSKELRNMEIEIGRARKRLRKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBP7</accession>
    <name>A0A6A6QBP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_181866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBP7"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2489430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="400" mass="42779" checksum="7D7008594DEDAB62" modified="2020-06-17" version="1">MNDANSTPQSATFKQESATGGGGEYDYTRSGNPTRTHLERHLAKIMNASRALVVSSGMGALDVITRLLRPGDEVVTGDDLYGGTNRLLKYLATNGGIIVHHVDTTDPEAVRKVLSPKTAMVLLESPTNPLIKIADIPRVSSITHAANPSAIVAVDNTMLSPLLQNPLDLGADIVYESGTKYLSGHHDLMAGVLAVNDPALGEKLYFTINASGVGLSPFDSWLLLRGVKTLGVRMEKQQSNAQRIAVFLESHGFKVRYPGLRSHPQYDLHWSMARGAGAVLSFETGDVNVSERIVESAKLWAISVSFGCVNSLISMPCRMSHASIDAKTRAERALPEDIIRLCVGIEDVEDLLDDLSRALVQAGAVNIFPNGFRAINAGTPSESEETVASSSKSAETSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC18</accession>
    <name>A0A6A6QC18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_622419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2489812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="162" mass="17957" checksum="49C82C1DE1FD9EBE" modified="2020-06-17" version="1">MDSSIRQTSPDHFEELSSSAAAFFANPPTQHDLSTSSEYSSAHNRKLEMSKDAIASSTSAILLDLISTIIDGGFSDKWFPVTEQHLLHSFRPSQRRRFMDTQQLVMTKSMVLEKGDGGQHSQFQQGEPVPLEPKDILGTEGFGEVDQVLSQIVSMYGVTAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QCH6_9PEZI</name>
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                <person name="Bloem J."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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            <begin position="1"/>
            <end position="23"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="496" mass="56601" checksum="FD7BC74B6ABB843C" modified="2020-06-17" version="1">MESEGPVHLNEEGGPKNEPALSTTREDWNAVIEGALGRLQWANIKPLPKDELLDGVIHAMYQPSRWSLGVDENSLNEPTLRYLDNDRYAKDKAMVWSNMKAVLRLATEWITNDEFLGFWVRLLSHRGGSDADIDENSPGAKEKVREVFNKMATRTHLTFGTLCDKDHVLRWGCTFPHPEAFQFFWQTTGKNARKLKGPVEVSTRNDDHDYCAPIIALHCCFRDLFHRKRDDFARLPAADSLKKQFKAAITLVHETAHAFFQVAQGRPCDEPLVFPTDFAGEVGHSWENYMFGGQIHGAGLWCKNEIRLMITPWADHEARVCHSVFISPAWVQTWFRKSTWEKSTLIRSGELSVGVLLKDPVLTGVETKNDSRDEQGNQVIKLTLLEHGEEIFSHYHRSPPRATASVGNVRKPWSLPVGVEEEYLNIDEHIARFRNKDGLYSITYFEDGRFVTSLWQEGPKGFVRKIFDPQIDKEFGALNARWKVEKHQVPGLPPAS</sequence>
</entry>
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    <name>A0A6A6QCY1_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="21"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="619" mass="64906" checksum="3F26EEBB498E5FC5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QDA9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
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                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Culley D."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="351" mass="39031" checksum="148BED70C6EF6F74" modified="2020-06-17" version="1">MADMSAESIQQKIQIARRDAEALKDRIKRKKDELADTTLRDVARQRVDALPRLTMKTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYSPSGNYVACGGLDNICSIYNLSAREGPTRVARELSGHSGYLSCCRFISDRRILTSSGDMTCVLWDLETGSKVHEFADHLGDVMSLSINPLDANQFVSGACDAFAKLWDIRQQKCVQTFAAHDSDINAIQFFPNGNAFGTGSDDASCRLFDIRADRELQSYTIGEPVCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGERVGTLQGHDNRVSCLGVSMDAMSLCTGSWDSMLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QER3</accession>
    <name>A0A6A6QER3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_566618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QER3"/>
    <dbReference type="OrthoDB" id="10406287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="204" mass="22835" checksum="E5D20A46FC1BFBAA" modified="2020-06-17" version="1">MASPTNPNSNRRPFPRPISSKSTDSYTSIYSEFLSEDELKHASSTYSEKRLSNDSSKHAPPSYTENRLSIPSMVNVSLSDTPRDLWSDARDLILEYNGLKYRKVGFAREHTDSAYQTTRLLELIDAIGICEKNLDLVAAALGMTREDMMADRRSREYGEAVGPVKFCAWLLAFLGVAVVVPLVLLPVHWWVLKGGDLNVEHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF18</accession>
    <name>A0A6A6QF18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_140815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF18"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="209" mass="23354" checksum="FB1674DE4921800C" modified="2020-06-17" version="1">MAAAEGVKTFVVEHLDPELEAWSSLEYAAIATESSKSGVEFLLSSVPESLKLPENLHNVQGLKIEHRSIETIYADRKDKVCLLDPSASKELSPADGETFQIFLFGGILGDDPPRDRTSELRKKGYEGRRLGPVQMTTDTAVRVTRMIVQDKIPLESIPYVDHPELRINKHESTEMPFRYVKGPDGQPIMPEGMVELIMKDSERGFGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF49</accession>
    <name>A0A6A6QF49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_575298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF49"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="477"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="569" mass="61851" checksum="E4D700A238B2FD2A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF53</accession>
    <name>A0A6A6QF53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_469881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF53"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF3">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="180"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="318" mass="36609" checksum="1B66C296FB1456C4" modified="2020-06-17" version="1">MSSLTRTLPASWYCSLPLYQLERRAVFLKAWYLLGPVTRFQVVGEKVDYEMAQVKLIVTRNSDDPRHIKVYSAAEGKELRSHLTVTGLLFTTISDNAPAFEDFFPDLESLLKRVDFTKLPYRRSIKYEGNFNWKTMVDGYQECLHCQYTHPSFSVYYPPTFYTVYNHKNFSQHIADPKKPNDGLFLYFFPNCTLNVYGGGMSSFRVCPTDKPGVTRMEFDYYHEKDGDKFEHYFKFVRQVAMEDYELCEKAQENLEKGVYAEGILNPIKETGVVFYQQRVFDLVCTQHETDKGPGPQAKGAASLNHVARSGLVDPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFB8</accession>
    <name>A0A6A6QFB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_530365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFB8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="75" mass="8565" checksum="84980DB0861B65EA" modified="2020-06-17" version="1">MAPRLWSYYTPVLFAFVSVTFLIYTTAFWRYWTDLGNLRRNADKMTSGNSQGLKDWANLAAGCFDSSCGVQQEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGN2</accession>
    <name>A0A6A6QGN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethylaniline monooxygenase (N-oxide forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_468783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGN2"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="565" mass="63396" checksum="953E8923B611BE85" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGT8</accession>
    <name>A0A6A6QGT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_145155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGT8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="161" mass="18073" checksum="A2A38983E94DD8CD" modified="2020-06-17" version="1">MDPREPLISLRDLASGGVVAREDRLRRRKDQFDHQIFQDDSTEFSDSVSKPAPGRTFAHCPYCLDLDWKNGKIFGGHHSDYLTNSTRYINCTSSDVRAAAERGCLSCKLVYDGLAAWNSLLVKDEKSLWGIPPSASQTRALRIGVSGPTFYDFFVEHGPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHI2</accession>
    <name>A0A6A6QHI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_530028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHI2"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="120"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="200" mass="21841" checksum="2A5B398EBD25CC3F" modified="2020-06-17" version="1">MATAIRTPAAPGTTPVVPKLVPAVPRILSKQGCFAPAAPGKVRDLNDNSTSSTPDTQSVPSTNDSESSASSSLPAPGVSLLNRKCKFPQLHDQMVGLTDKEAMQHALEIKSTENGSTDIVICAIDLEWHDVEPRELTEIGLAILDTRDFHGLKDGPGANGENLMKQVQFYHYRIKEHGHMENKYCIGHPERFEWGIHPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI63</accession>
    <name>A0A6A6QI63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_565435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI63"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="547" mass="62995" checksum="DE3D7A3883A3F34F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIE3</accession>
    <name>A0A6A6QIE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_106120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIE3"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="141" mass="16197" checksum="26C77FCEDABFAA2C" modified="2020-06-17" version="1">MADSQLFEETFTIEAVDNQKYDRVSRVTGQSTDGGTKFWLDINHELFPLNEKDSVQMVLASTLNLDGSKAEKGWRELSRMDSTLADMYDYVCHGKVYRFEEGAGENIKVYISFGGLLLYIDGPYKKLTPLRIDYVYMLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJH2</accession>
    <name>A0A6A6QJH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_574402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJH2"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000133">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="594" mass="64935" checksum="CC58D313CAD6C31C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJM9</accession>
    <name>A0A6A6QJM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_515440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJM9"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="14"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="341" mass="36085" checksum="E51C2B22C95775CA" modified="2020-06-17" version="1">MAEQNIAALLPAPSTPLEVTAVPTPTPSMGEVLIKNHCIAIQPLDAKILHAGYTGAGNLEAFPAVLGTSLAGIVEAVGEGVEGFKVGDRVVADTGAYSGIPQKNLRQGCWQKYVIAGAKSVAKIGDTPFEQAVLVDFPLQTAVAALHNFLGMGKPGTGFADEKVLIWGAGGAVGSYAVQYSKSVGHTVIVTASARDTDRQKSLGASTVLDYKSPDVVEQLRAYAPFKYLFTGSGDPASQKALAALLQPAGGSFASVLGGDVELPENVTRVYLPFSQVSQKEEHAAFRDWWYGEYLPKVLTEKLVQPVKFEKRDGGLGALWDATKEVFEGKIKGKVVLNPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKN0</accession>
    <name>A0A6A6QKN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_99126</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="129"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="442"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2491957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="520" mass="57329" checksum="8FEA80170744BCA4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2492804.1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="112" mass="12945" checksum="DB964C4D2052CCA9" modified="2020-06-17" version="1">MRVLAEIQPTPHICIMYLIVLRLSSLLTVTFVQDSFFLLFIDLILRFIFEELFLLISQAAMKLDTSLAIIFGTVTILQVLGALVKVVMRFFRRRRIVEGMLTKSPWLKVPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLC1</accession>
    <name>A0A6A6QLC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_96920</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
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        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="334" mass="36416" checksum="8EFF230671ED1F65" modified="2020-06-17" version="1">MTTEKTKVVPLTCHGHSRPITHLSFSSVVDDDQYYLISACKDNNPMLRDGITGDWIGTFIGHKGAVWQARLSSDATLAATGSADFSAKVWDTHTGEALHTLQHNHIVRAVAFPNQPRPQILATGGMEKKLRIFDLSRSSSASSSPTYDTAASSVTPPSYEIGPGVHAGSIKSIVWGADRNVIITAAEDKMVRWWDLRSRSTIGEFAVEGMVGTCELDNTSADGVLSVAAGKTAYFFDSMQPATLIKSVKTQYDIASVALHGAQRKFVTGGSSQNDTWVRVWDFDEEKELEMGKGHHGPIWTISFSPDGKLYATGSEDGTIKLWKFTTGPYGLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN12</accession>
    <name>A0A6A6QN12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_573851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN12"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF4">
        <property type="entry name" value="SIRQ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="11"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="389" mass="42815" checksum="7A6E04FED089E69A" modified="2020-06-17" version="1">MSTSRTSGAHALVFGASGLIGWALVDELVKGYPGDNTFSKVTALVNRPLSIENSYWPTPDPSRPELQLLSGINLASGTVEEFTEVLREQVAGIETVTHVYYFAYKQDDNPKIEIEANAKMLERAIGALTKLSPELSFVVVPSGTKGYGIHLETKPFKTPYTEDMVLPSSNDSSVHYAEFQNILTEKSEGKKWTWCDVRPDAVIGFAPTGSTYNLTAHWATYLSLYANVEGAGSSVAFPGTENAYNSLLNEASSSTIARLAIWASLHPEVSAGQLFNVADSARAESMRDRWPKIASWFGLMGIGPAPESDEASLLPSKYVQKHEKVLKEKGMGVLVWKAEFLDSYGFYLDFDRQMSLEKCRKAGFEEEKDPNEAWFGAFEKFRGAGMILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN51</accession>
    <name>A0A6A6QN51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lysine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_82054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN51"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="257"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2493516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="612" mass="69903" checksum="2F3B22341FBA4B39" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNP9</accession>
    <name>A0A6A6QNP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_582805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNP9"/>
    <dbReference type="OrthoDB" id="5396104at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="393" mass="42112" checksum="E1712122689B7FBB" modified="2020-06-17" version="1">MAQHPDTNKSCNKKRPQSKAARLTVHPAPFKPTLLSIPPSPFSPRIPITPEFPSLNQRAITKAAASATTLSSPPPPSPLQWLWQCHKCSRTYQLGVTRRCLDDGHFFCAGTTTIKSWRKSVNPRRVRTHRACASEFDYQGWKTWGQWRRGGDEDVRMIDAASSDAYSVSSSSSEAESELDARPAKNCWNTCDYPSECRWGKQFGVHTPAKVDAVVIPLCPPPPPPPPPPAPTLEMQLEGVSDGGVKKSGKTDFWGALLASATRRKTVGSSPLAQVVEEPERESEEEAETVTPPCPALLSNGSGSSSSSLGHSLTVMAPVTLMDIITKKAKKGKGAGLKAPEPVVMAGGSGSEGDVNRAVSRERSSTAVPVGSVERVKGSDSGYFSHSEDAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP81</accession>
    <name>A0A6A6QP81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_67532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP81"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="15783" checksum="3292ECD0AE289CCF" modified="2020-06-17" version="1">MRMALARSVLQRGQNQEHQLLGICVATLRNFPHLLFCLPNHLLSPLHFLFAVCFLLFQSSTSSACFCITSASLFCLYYMPSSPPLAVTTTLCLPFWNWQSAWGSYQRQYRRQYRARKGRSMVSGYQTGLSTERDATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPM1</accession>
    <name>A0A6A6QPM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_64089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPM1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="86" mass="9584" checksum="68D03A81A7AF036F" modified="2020-06-17" version="1">MDDRCQNMTLSNLLPSTAVCNLILLKITESRYRLFFKMSHTVLRTNFRPRSAASTLLCSILLSMLPARSGSVPQAWAIITSRLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ27</accession>
    <name>A0A6A6QQ27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_463997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ27"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="178" mass="19267" checksum="0FCC5037F5D5AAEB" modified="2020-06-17" version="1">MPLQFLRCLVRPSVFPIPRRPTSCAIPSPIARVASPTSLVLPIRSFSASASRPSTFNQVLRGARQSQTARKLRSPALANRPEMKGVCLKVGTTKPKKPNSGERKFARVRLSTGQVVTAYIPGEGHNVQQHSVVLVRGGRAQDCPGVKYRLVRGALDLGGVGNRITSRSKYGTKKPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQM3</accession>
    <name>A0A6A6QQM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_589291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQM3"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="245"/>
        </location>
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        <location>
            <begin position="293"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="36677" checksum="87B2DDCD20DC9A37" modified="2020-06-17" version="1">MPPPLLPPAPLTLHVLSDLHLETPLPSHLYQTYNPLPGGWAGCTHLCLLGDTGLLAHAPLFTFLRRTLLHNPRLHILYVPGNHEFYDTSIPAGLTLLHAFAAEVAKDGEYGAGKRFWVLDRARVDIGAVTVLGCTLWSKVSAEEAGEVAGRMSDMRRIAGWDLGRWGEAHERDLAWLNGAVGEVEREERGRSVVVLMHHSPTTLPQAVDTRHAGGGMLSAYHTNLSTELCWTSPVVRLWAFGHTHFSCAFEEPLTGKLVFANQKGYAGHEGVGFDARRYVEFEEGKWVVKTSKARRRAGGGGSEENVENKKREDTRKSVEKKKNEKTSCCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQU2</accession>
    <name>A0A6A6QQU2_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Zf-C3HC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_511359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NuBaID_C"/>
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        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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            <end position="246"/>
        </location>
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        </location>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="448" mass="49675" checksum="05D8DA5331690537" modified="2020-06-17" version="1">MTSPQPVALSTTKRKFHKLLDNLNANKSTPNLASSFRSANTSTTSLAVPTTTEPPSKRSRHSDVSMISRMSMDKPRPHASPSTIRSVKSKTTASTPPRKTPNYAPYSQDAFLARLKTFADVKLWTMKPDPINEVQWVKRGWVCEAWNTVACKGGCEARVVVSLRPKRKDEKGEEIEGSEDWSVDVEEELVAAYAERIVEGHAEFCLWRRAGCKKDIYHIPIARRDVCEADLSRRYQSLKAIEPHLPPFECVKFTGIDPASLIKCLPPSFFAAAEENAATEETPPPSLTAFAFALFGWNGVAQDGLYIAQCSHCFQRVGLWLYTKERIATMAKKVNAEESQLLLNLLETHREHCPWKNVEAQANPPDGQVAGFAAWRTLQYVLGVNKRRDTTATQGSAEVGGEADVVGKKDGAEKGDEDLAGRWQRLKSKLKRSTSKRSLKSLGKGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR27</accession>
    <name>A0A6A6QR27_9PEZI</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="549" mass="59548" checksum="0B5AC39E6CC17565" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRY0</accession>
    <name>A0A6A6QRY0_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Ezra D."/>
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        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAF2494892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="664" mass="67468" checksum="526EEE667F3C0D95" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSS1</accession>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
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    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="353" mass="38869" checksum="9AAF620973341278" modified="2020-06-17" version="1">MLARGVLCRLAADVPKTSTHDLARISRVLHRAINARSASSIASIGGLSHAYKLAYALSRRSYATAAATAKKPTKTVKKVTVKETVTKKPAAKKTAVKKTAAKKKTATKKKAAPTKKRAAKKAAPKRKPAKRALTEAGKARKELAEQRARHNELKEAALMTLPKKLPISAWMVYVSEIQEKGKGKSPATEIMKQGGAQFKALTPAEREHYNHLANQNKAANEAAYKEWVLSHTPEQIRLANNARRQLRAQYTKLKNAGNVKSSRVYPKDTGPIKDERRVKRPQNAYMLFNKERRDSGEMKGISVPDSSRLITSEYKALSASEKKKYEDLALAAKKQYAADFAATYGHKSQAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWQ1</accession>
    <name>A0A6A6QWQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_458650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWQ1"/>
    <dbReference type="OrthoDB" id="2205143at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06992">
        <property type="entry name" value="cupin_GDO-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02216">
        <property type="entry name" value="cupin_GDO-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047183">
        <property type="entry name" value="GDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517">
        <property type="entry name" value="1,2-DIOXYGENASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517:SF1">
        <property type="entry name" value="CUPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="337" mass="37908" checksum="1FCDAD734580DB1B" modified="2020-06-17" version="1">MSSTATISGQNGISTHVDREQLTKNLLKAAEDYHTKPLWAQMARLNPPLPNPKCHPHVWEYEKIRPSLLQAGELITEKQAERRVLMLVNPSREAPYTTDTIYAGLQLVMPNETAPAHRHTAFACRFIIEGNGGFTAVHGRRIQMQRGDVILTPTWNWHDHGKDGSGPMIWLDGLDLPSFVHFPVHFVEHYADPRYPAKNVDTSASPLVFPWTRMKVQLDAGSGESTTKGYYKADGSEISRTLGTSATRISPGKSTPKIQETASSIFHVIEGSGTTTIDGREFSWKKYDTFCIPSWHEYQHHAGDGETVYLYRVHDEPMLKSLGFYRYNGQDLESLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWS6</accession>
    <name>A0A6A6QWS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_525710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWS6"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="254" mass="28434" checksum="0F71218C90E3B905" modified="2020-06-17" version="1">MAGRGRGGGFRGGKSAGGLDFPWEHDPDIDQYLKWEPDKLFPEIEPTIPAPPTADELRSVYHSRRIRDMRRAGPFWATGDLSKRAGRGAGGRDNKGNDTFNAFTGMETYSSKYVPKKRVLPDLKSYPFVKEFFPKELWDVMGISDDEDDKKKAADGTKPPPKKRKMLQIAKANDMSRLEALEAEAKRKADAGEEDDDDEEKEEEDGEGGEEVQDDDFEEDESDGDDYNAEAYFDNGEDDFGEEDAGGDDGGYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXW4</accession>
    <name>A0A6A6QXW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_337747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXW4"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="165"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="40322" checksum="1292C924B6E07AC7" modified="2020-06-17" version="1">MFSFPNDKAPDSKCYFTHSLLPSYIEPTLPPTKKKPFSIFLTQPFTHTLDLVLPEEIYELCRQELDGDAGTLRYARVNMTLLEVLSKDFFTEYIKKGNIMMLSEGRPTVDNVFSLYEGILRIELDRPTYERCGLVGKPIEDGGKRHKKARYVIELDLRSPSMLHGKRGFKRLIWACQGVLNDSLTWLFHDLQPSNESNETAPIFAFHPIIRTMKPTTTPLPSTKVPVLSSASLPDLYDPDDSASLLEYLHLLSLASPRLCASDSIDPYLSRYEVPEFGANGGTEVRNLVNVRWHGFIPPIFVRRLYLDVLKRVEGKKGKETEQWVALNANGFGGLGGGGPAYSVLQCGARDTLCWVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYA3</accession>
    <name>A0A6A6QYA3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="560" mass="64049" checksum="05C110C74B763C36" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYM7</accession>
    <name>A0A6A6QYM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="432" mass="48522" checksum="5FDE15E6A2CAD8BC" modified="2020-06-17" version="1">MASTLTRSTGVTKNHRKSFQSNEQRRKSMEPPGEAGKQHRFSDPGSSSIFTAISTIFGFVDFVTALKEVSDDNRVFISLIERVRHDVDEAFRLRRCRRVADHFASFPRERNWIDGTIMDVQRALNDLGLYVENARIDMDGRVEVKMKNKFEWVLRNQQKLITRQIALSTCHQSLMIAVQAMQGVEMDLRLGASDDSSPTLLVPGRGSGEMTEDSHLGPYSRRKRRSFSTRSDLQMNAQEIEIASENLPEPVTIMPVALPAIASSEDSLRPHLSLRGTSGYFPSLPILQQNGKPYPELPGCLPATRSMPDLPISEEITPSQDERQSIPRKPIASNPRSLPVIPRHPSLRTGLSEWIIPWGEVQSEKIVRDASPTSSNATVTSSPDTDSSKEAAIIERAIPDRVTQQPRLMTTQERRRLAHTRRLAAAYDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYY2</accession>
    <name>A0A6A6QYY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BU16DRAFT_559410</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2497671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="469" mass="54986" checksum="C3A8E69F2407D429" modified="2020-06-17" version="1">MASVTPTSSIAAQVTQAMINRFLEDSLSYANNPNAALRGIDIFVRKVWAEPRDKWPTEIHRDVERTRSSSADILETFATYRENDSLYDQAARIPTSEMERVQGFLEEGVHRWRPNYNRIMFLALLRREQRPYVGLSSNVLRLTEDYLKNFNWHHLRRKWEPHVRRLNEQGRNIEDYFYEACYDGNREWPADKVEFLTLTNCFWQLIFQGVNWSVDGSLIPPAIFLMMGMQDELQHIRDLEEMGETWADERAEPWVEECRRDLRRDCTLIFQLLSRPLRKIRDDLAVLGRRELQKVRIISKHSFVEIHNEDWSILDMVTSPTTPGPGNCDICLEAHNAANWVKTNKCSHIFGRECLRAWFASRNTCPMCREVFTVPADRLRSEIFLTPRHDSPLLRPMLAFLAMCRTLKNFGPLVNEIFHHTRGLGQDLFPDSCEVIVTIFELFYEIMALSPELRRPMREFGINFGQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZL1</accession>
    <name>A0A6A6QZL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_505971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZL1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="36053" checksum="26DE83A553FEEAD5" modified="2020-06-17" version="1">MSPPYGAETTGEELVQAFASQIKGKVILTTGVSPGGLGAFFVEVIAKAQPDLLILAGRDTTKVQKTADTITAAHKDVKVRVLKLDLASLKQIREAAATVNSWTDVPHIDVLMNNAGIMACDYGKSEEGFEKQFATNHLGPFLFTNLIIEKVIAASRPRVVMVSSDGHRLGAIRFDDYNFDNGETYDKWRSYGQSKTANMLFALSLAEKLGKRGLSAYSLHPGVIGTNLGAKLDWEVDFNDLRERALDKVQGNKEGWADFKFKTGDSGSGVATHVYAAFDPSLSGRNGAYLQDCHVGDPWTDTVKPWATNGVEAERLWLLSEKLVGETFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZY0</accession>
    <name>A0A6A6QZY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_526301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZY0"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="57" mass="6197" checksum="36D54335BA93A5CE" modified="2020-06-17" version="1">MNLVLDEAKEITRDDEGNEGSRDLGLLVARGTLLVLISPIDGKEEIANPFLNADDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R093</accession>
    <name>A0A6A6R093_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_538367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R093"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="238" mass="26001" checksum="ADD3ACE6EE92CEDB" modified="2020-06-17" version="1">MGPPEKPPEPAAKKPKKSQLYARTPTYAGPPRVEGTPKTDSAQPTPSKSTLPTTAAPTASGNSPLKRTYTERDAHSSSSSAVGDASDSDTGTHRSRAELTALSKLQLVELVWQLQQDARRMAAELRAARRPGPSGAGGLRGEVEQLRAVIRDGILEQMDFPVPFGDAVWRVEGIVGRRQVWMQAFGPAQEGFEPLKRFVMGIVVKRKEGVLTVIERGFRVLWREGEGRYVIRGNYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0H4</accession>
    <name>A0A6A6R0H4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_327270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0H4"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="138"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="476" mass="54065" checksum="5A7E470FE341476C" modified="2020-06-17" version="1">MAIPNPFRRTTENTRNCWGYTFEWTDDHLTSEQAEPLKHSYDVLAEECLNRLNVLYPPESAALPRSNSLEAPKEKEGEKSDKPDVPRRDLYALLRDHHGEDPKLDQLWTEVNTVPDWVDWAQIERGQDVFYRYGGPALTGLTYQSLLGGMGAARVVETLARTGGFSPKVARGRLFETTQHILQCTRSLESMQPGGEGWASSIRVRLLHCAVRQRIMKLAEQRPEYYNVKEWGIPVNDLDQMATIGTFSATLIWLSFPRQGLFLSQQEIVDYIALWRYIGYILGCPTKYFETPTKAKAIMETLLYNEVNPSDMSRILAQNIITSLENSPPTYVSAEMLIASARWLNGNALADRLGLPRVSIYYWGLMAGQCIFFIFMCNIYRSTPYLDRKNVKRLKKLFYAIIVESKYGLAGIETVFDFKYIPQFTTITEMGDFGANGRHVGAEARNLRALLIFAGFCGVGTYVSFKIGSVLLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1A9</accession>
    <name>A0A6A6R1A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_455813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="574" mass="65129" checksum="AF0DC3563F0A243E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1T9</accession>
    <name>A0A6A6R1T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_615403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Checkpoint protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="241"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="584" mass="65131" checksum="65BAFD6C613A9ED5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2H8</accession>
    <name>A0A6A6R2H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_524943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="69" mass="7589" checksum="FBCE932FB605123B" modified="2020-06-17" version="1">MSLSSREKLAAINREYKHKEDLIAKAKAEWVKKTLPAGAKSASGDLITDPENPKFDLEAYLTLKAADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2Q3</accession>
    <name>A0A6A6R2Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_480924</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="27552" checksum="7C1F4B40FCDDA537" modified="2020-06-17" version="1" fragment="single">MSGNTIVLITGGNTGIGYESVKALYVSSKGPYTILLSGRSIEKVNNAIATLEKEFSDTASKLVPLQLDIESDESITAAFETVKSSVGYIDVLINNAGAQFDTDMADGSPASIRTAMNRAYNLNVTSTQVLTVVFEPLLLKSKSPRLLFVTSGLSSLTTATAGLHPRPGITYPFGYRCSKTAMNMQMLGWCNRLKEHGVKIWCISPGLLATGLAGNPEAMKKMGAENADVGGIFIKDVIEGVRDDRVGLVVNRAGVQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2R0</accession>
    <name>A0A6A6R2R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2R0"/>
    <dbReference type="OrthoDB" id="3935170at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="15381" checksum="F846384DE87F1349" modified="2020-06-17" version="1">MPTQPQSPTRHVSFAEPASLSALTNRSRLLSISEPQPRPAPILREGTRPTIYRTRPSSTQLKAPPSTLTQSVQGLPSPTPSSSDIALAYRTRYANYLASTFNISVQAAQVETDYQLSSRRASECSEAETEPRGEHEQRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2S8</accession>
    <name>A0A6A6R2S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_261197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2S8"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025353563" evidence="1">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="247" mass="27272" checksum="837496B0D07F6A86" modified="2020-06-17" version="1">MVCFFLVGVGSCGRLLTATGEMSVLKWSGVLCGRPREARDKAGLAAVSTAFAHLRPTHGIPGWQAHHAEPPPFGSSALANICAALEVEPVPLLLDRPRAGLQPYPLRRRQDHPGQDQWSALLRPILLRHQLLRHVRGGIRDALRFGIRAGDKAVFQAEKDRDTGRSRGLGFVRFSHVPLVICDGNHGWSWLVRRRRWPGNGPFFRSRNFGSPESLLRRTGSASCASPMSCWSLAMVIMGVPAGHLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2T6</accession>
    <name>A0A6A6R2T6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_503046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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</entry>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Magnuson J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 269.34</strain>
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        <subcellularLocation>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3F1"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="45183" checksum="37F1CEA98D71992E" modified="2020-06-17" version="1">MRFPPLAVSTQISKPSVLRARFLYFQSPPVFVLSSVAGSLPHSRVCVCSFISRFCIPSVALSPFSDHQTISGKNHFSAATMPGRKAKAPNNFCDPKADDVPASTSSSITPIPSKSNPESSNATPNSNPTSSQFTSKAAKPGARPPLTHFLCFPLVTPASRPQLQETLARFKEDVCATENVPEKAIRPLGTLHLTLGVMSLDEESLERAIAMLQSLNIAELLNTTSAETTTPSAAHPTPSDPKETPNTATKASLETAFASSDISATTSACSSGQTGATAPTTLPGPLVISLQGLHSMHPPARTSILYAAPEDPTGRLYPAATKLRDLFTQAGLMVPDDRPLKLHATIINTIYAKASKGGRGAGHGANAKALLRLDAQEMVERYRGFVWAEGVRVERVAICKMGAKKVVDAGGVVVREEYEEVAGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3P7</accession>
    <name>A0A6A6R3P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_503128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3P7"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001529">
        <property type="entry name" value="Peroxisome biosynthesis protein-like protein (PAS1/Peroxin-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="569"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="903"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1111"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1181"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1195"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1215"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2499179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1262" mass="135219" checksum="EA2AF2727AA578BF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3Y2</accession>
    <name>A0A6A6R3Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_579029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="947"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="977"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2499468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116796" checksum="205A510CA342216A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R469</accession>
    <name>A0A6A6R469_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_605101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498730.1"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:fatty acid synthase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
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        <property type="entry name" value="PKS_DH"/>
    </dbReference>
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        <property type="entry name" value="PKS_DH_C"/>
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    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
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        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14765">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="43"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2534"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1166"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2498730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="2622" mass="286523" checksum="D9DBC971C3317F6E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5G6</accession>
    <name>A0A6A6R5G6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_559023</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="366"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2498993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="419" mass="46235" checksum="DEF7D7CE5FA6260B" modified="2020-06-17" version="1">MAPLAIMTAVTTAADSSDAALAFLKEAMPPCALKCMVEYIPKSPCSLTNTTCICTNVPLNQEIGLCVAGGCTIPDALTTKNVSLTMCGAEVRDNAGVPYVCAIVGSALAAVFVILRLFVIFTPGGKKPGWDDAMLLLCLALSLIPGFLSGFLRDAGLGKDMWTLKPDQITHFLFYFFLGEIAYIEGMGILKIAILWFLLSIFPDKQFRKYVFIVIGLCLAYCVAFLFATIFQCTPVSYTWTQWDGLHPGKCNNIHIQGWLSAIANITLDIFVMVLPLRQLSRLNMNWRKKMAVMSMFLVGTFVLIVSILRLQALISFANSQNLTWDYVPGSYWSTIEFDVGIICACMPSLRALVLRYFPKLFSTGTTKGSQPYSSQRSDKKLSRAQVDPELSTSDFIRLEDRESMHGKSADGSVRPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5S4</accession>
    <name>A0A6A6R5S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_536191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004184">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3800580at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="296"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2499909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="827" mass="91813" checksum="6439F194966B0005" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5S8</accession>
    <name>A0A6A6R5S8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_282256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5S8"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0779">Telomere</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Telomerase reverse transcriptase C-terminal extension" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="135" mass="15258" checksum="381189558CD040D6" modified="2020-06-17" version="1">MFLDTGFNSLDTVLANVYQSFLEAAVRCAEYMRQLATSRKPNSRLLIKTIDHLVALAAVLLQRPSRRVTTTHQRRCAVGRRQVQWLCCTAFHAVFHKRQTQHRELLRWLDSSLAAVVPTSRAELQLLAAATAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R681</accession>
    <name>A0A6A6R681_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_534915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R681"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13483">
        <property type="entry name" value="Lactamase_B_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38894" checksum="B86CEE2CEA1812E6" modified="2020-06-17" version="1">MSLTVKALNGDTSFLLTFSPPVAPLSSPGLFPGSFTLLIDPFLCGSAKILSSKFSISKHITKPCIDSLTELDQEPDIILISQDKPDHCHEETLRQLPPDCQSTILASPAAARKIRGWQHFAPSQVLSMDRFSESDQSSIFRMTLPAFSPRGSPGEVTVAFMPARRDISGLHNAVGVTYRPPCSVLSASLGSYMDLPPTPPASPRSPRTISAGPRTIVPSPYNDREKTVSVLYSPHGVSYEIIRPYASSHLVSESALPLDLLMHSFDRVTNPIYLGGNIAAGSPGGVEIARNLLAKAWISAHDADKINKGVSVKQIRMRKFGLDEIKRMLVGGDKLPGPSVSIQTNVVSLPAGEEFRIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6H1</accession>
    <name>A0A6A6R6H1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_578374</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6H1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
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        <location>
            <begin position="153"/>
            <end position="325"/>
        </location>
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            <begin position="349"/>
            <end position="497"/>
        </location>
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
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        </location>
    </feature>
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            <begin position="81"/>
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        </location>
    </feature>
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            <begin position="103"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
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            <begin position="523"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="545"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
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        <source>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
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        <source>
            <dbReference type="EMBL" id="KAF2500405.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="555" mass="60319" checksum="E7CE861E3EC69199" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7D2</accession>
    <name>A0A6A6R7D2_9PEZI</name>
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        <submittedName>
            <fullName evidence="12">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_256076</name>
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    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="270"/>
            <end position="332"/>
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    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="375"/>
            <end position="494"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="149"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
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        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="162"/>
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    </feature>
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        <location>
            <begin position="209"/>
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    </feature>
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        <location>
            <begin position="570"/>
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    </feature>
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            <begin position="628"/>
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    </feature>
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        <location>
            <begin position="656"/>
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    </feature>
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        <location>
            <begin position="781"/>
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        </location>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="892" mass="101419" checksum="8C08041524FB8D72" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7E2</accession>
    <name>A0A6A6R7E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_524122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7E2"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2499663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="249" mass="27864" checksum="4326A9E7183DE275" modified="2020-06-17" version="1">MLLNEKTAILTLKVLLVPYSEHHVPTYHEWMQDEALQKATASEPLTLSEEYAMQRSWRLDHDKLTFIVCTAPTLRPQVVTPTEHDAPDRMLGDVNLFLCEADDDEDDDAEESLKEEDAVKERSIIGEIEIMIARKELQGSGYGKAVLLAFLAYIVSNIPAIVGEYSKGHGTEGGKGTGSGLDLRYLRVKIDGENARSIRLFESVGFKKVSETVNYFGELELRWDLQGQNVLEIEGLKGVEMECLVYGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7U1</accession>
    <name>A0A6A6R7U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_250072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7U1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="117" mass="12724" checksum="49F8D5BFDBB7C121" modified="2020-06-17" version="1">MLALTWTSRPFSLGATQCTGPWLGVSRSSTSSPPPWLYHTGTARRRINTCYPREHSQRCNLQRQCSSRATSRLTAEGTSSPLDLPQAALSGSLAIPLDDDTEPARVCSCHCCTMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8K6</accession>
    <name>A0A6A6R8K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase IS30-like HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_598708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2500949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8K6"/>
    <dbReference type="OrthoDB" id="5405453at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS30-like HTH" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="202" mass="22521" checksum="466BD1B64761688B" modified="2020-06-17" version="1">MPVVVFKQAGLKGTTAKRTLVDSVLVRRGPSQGKRVLGTLRWALGLPRRSTAAEYPVVWGMRARKRIIQQGRSLVGTTPTGVRGDARLPKACFHVSAILNGRLPVPYKMTLSTPQRQLTRDERLRIQTFHEAGLKLREICKRMGVSLSTVSTVINGPTTPTKSKGRRPILDTPTRHRLVLHATLNADQRRKPWRVIANELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9H4</accession>
    <name>A0A6A6R9H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_192431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9H4"/>
    <dbReference type="OrthoDB" id="4179303at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="520" mass="58679" checksum="B8F81CE067FF24ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAG8</accession>
    <name>A0A6A6RAG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_523246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAG8"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="56"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="25354" checksum="9CA6423ABE473928" modified="2020-06-17" version="1">MAPSTRSSTKTTSTNSDTTSLSPTKMRKSKGKGKAAATNPNISSATADAETTGAIFFWREYGHAYGFLSQWYESEWEHEGTSYISAEMWMMVEKARLFGDEDVAQRMLLESDPKTHKVLGRQVADFDAKVWDDNKLRIVEEGNWHKFTKSKQAEELQKLLLATGDRELVEASPFDKIWGIGFAEKGAERNRHKWGQNLLGKALMTVRERLREQEEVASIEEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAP4</accession>
    <name>A0A6A6RAP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_522555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAP4"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="285" mass="31103" checksum="70A63E3CA3766698" modified="2020-06-17" version="1" fragment="single">MSPNWTHLIRFIAVEDGLVHLGQVDTAKTTDIGLATVEKKEVKAKLVTGSIFDGVVTDKVLTVSQLLSPIEKSEVPLIRCLGLNYHDHAKEAGMPIPTHPVLFIKPRTALSGPFPQKISIPKFVQDETTDYEAELTLVISKDGRDIPEDKALDYVLGYTAGNDVSARTEQFRNSQWSFSKGLDLSAPIGPVLVAPSEIDPGNLGIKAILNGDVVQDSNTKQAIFSIAHTIAFLSQGTTLERGTVIMLGTPPGIGAMRTPKLWLKKQDDMRVWIEGIGTLVNEVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBF3</accession>
    <name>A0A6A6RBF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_499896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBF3"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="52"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="407" mass="45184" checksum="D756B2E96CC17742" modified="2020-06-17" version="1">MVHLEPFSVELWMDKYETKAKYQLAETCCASISIEDLKSFSDDKSAEVLQPATKLTYGSIRGSDALRSNLAKLYSSRGGTPLSPESILTTPGAIAANYLYFYSLIGPGDHVICHYPTYQALYSVPASLGAEVDLWHARPEKAWIPDIEELEALIKPNTKLIVINNPNNPTGAVLKKSLLKKIIDVAAKNDIMILSDEVYRPIFHSITPVESEFPPSLLNMGYSKVTVTGSLSKAYALAGIRVGWLASRDQDVIEKVAHARHYTTISVSQLDEQVAAFALDANTVHNLLSRNIQLAKKNLALLEKFVNKHDDLCRWVRPLAGTTAFVKFHKDGDPDSPIDAVEFCKQLLEKTGVMFVPGDESFGKEFLGYVRIGYVNDTEVVEEGLQKVRQFIKKEFDDLPLSAQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBF7</accession>
    <name>A0A6A6RBF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_546882</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBF7"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:asparagine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EcAsnRS_like_N"/>
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        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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        <property type="entry name" value="MCP_transmembrane"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    </dbReference>
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        <property type="entry name" value="asnS"/>
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    </dbReference>
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        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="184"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="518"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="617"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="708"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2501794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="808" mass="88080" checksum="EBB700ED59164ABA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBH3</accession>
    <name>A0A6A6RBH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_476526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2501050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2501050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="328" mass="34192" checksum="60D27314DD4F14C3" modified="2020-06-17" version="1">MSAPLANIGILSIGSMGLGIAKLLQAHNYRVFTNAANRSSATQARASSASISLVNTDTELVAQCDYILSIVPPRDAVVTAGRIISALNSTPAPRATSGHPLYFLDLNAIAPSTARAINATFESQTPALRFVDGGIIGGPPSLASDSTWKRPGIPISGPHALNAAPVSGQHLADTLNTEYVSPTIGSASGLKCCFGAINKGIAALALQSFSTASSLDVLPQMQKYLEEYTPAVGQLAARGLVGCPPKAYRWVEEMNQIGTCFEEEGGWGAQGQVFGKVAEVFDVLGKVVDGRGGTEGMGKPEEVVEVLKADLRGKSTGVPVEVLEQEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBJ4</accession>
    <name>A0A6A6RBJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_532573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBJ4"/>
    <dbReference type="OrthoDB" id="10556326at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RING-H2"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="480"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="EMBL" id="KAF2502011.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="108" mass="11770" checksum="FBE485E646A5C729" modified="2020-06-17" version="1">MRTNPQAAGGKKRKETGLRASMRRLWARAVELWNVAVDRVQNPGGIEEFSHSRSASAMGLRVERTTTTTVQRGNTLAPSTPVLKITVGGGRRSRVVRKGKGGEAEDWA</sequence>
</entry>
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    <name>A0A6A6RCP5_9PEZI</name>
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            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Yoshinaga Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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    </dbReference>
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    </evidence>
    <sequence length="414" mass="44252" checksum="10A9C8366E4A4C4E" modified="2020-06-17" version="1">MNDVDEVDLYEVLGVTSGASKTEIKKAYHKAALSHHPDKVAEHERTEAEIRFKSAKQAYEILYDDDKRTLYDTHGMAAFDPNRGGPGGPEVDIDDVLAQMFGGGMGGMGGMPGMGGMGGMPGGVPGMGRQPRKGRDVEQEYEVTLEELYKGKTTRFANTKNVVCQTCKGTGGKEKAKPHQCAVCGGNGATTRLRSVGPGLVTQETVPCSTCSGTGSLFKDKARGAREGERIVLAGEADQLPDQEPGDIVFGLVERPHDVFERAGSDLKADLKITLAEALTGLNRVVVTHLDGRGIKVHVQQPQGKVLTPDQVIKVPGEGMPVKKSDAKGDLFLVVKIEFPADGWIKDEETINKIKEALPGPTKSEDAVPETTDEVDIDYDATLEDFGAGSDDPRAGAGWEDDEEEEGGPQCATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCW8</accession>
    <name>A0A6A6RCW8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCW8"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="6">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2502304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="238" mass="27828" checksum="35122649F5065F9F" modified="2020-06-17" version="1">MFILLSTIFIFFTPFYCLYKPPTFLIRYFQYRWPDTLWHVPTRSRIIALTIDDAPSEYTKEIMQLLKDNNATATFFVIGAQVSGREEILSNLVRNGNELGNHAMHDEPSRSLSGETLTSQIQSVEQMIDTAYKDAETDRTNPKLFRPGSGFFSDRMLAILYKLNYRLVLGSIYPHDPQIPYWRVNARHILSMLHPGGIIICHDRRSWTLPMLRKVIPEMRRRGYRIVTVSELLREIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD49</accession>
    <name>A0A6A6RD49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding oxidoreductase ToxD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_612147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD49"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="10"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2502491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="38234" checksum="4CF7435DB33F0C76" modified="2020-06-17" version="1">MKAYKLLSKGNAAVVDAPKPALRPEYILVKVACVALNPTDWKTIQNTNFDEKSPLTVGCDFAGVVEEVGSLLTRPFKPGDRVWGFAHSCHTSQPEDGAFAEHVVAKGDLALKIPDHMGFEEAASLGLQVYTVGQGLYQSLQLPWPTAPVKSEEKFPVLIYGGSTAMGTLAIQMAKLSGLEVITTCSPHNLDFVKSLGADQVYDYNSPTVGSDIRQFTNDKLRYVWDTIGEGHTAQICADALSSSAESTLYYSTLALVEFPRTDVKTDVTLGYTIFNEAFDMFGSFRVEAYLPNFEFAKKWGLVAAKLLEEKRVVPHPVEVREGLERIGEGLKDLEKGRISAKKLVYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RDB6</accession>
    <name>A0A6A6RDB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RDB6"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="72" mass="8008" checksum="E5F25A40CEF24B7E" modified="2020-06-17" version="1">MLGKAISSLHSTHRQLEDTNSDFYPSISPKDIKCRDTPTSSCSYLLITTCIRITLLVLFFPGPPYSRLATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REE8</accession>
    <name>A0A6A6REE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_554794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REE8"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="149"/>
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        </location>
    </feature>
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            <begin position="330"/>
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        </location>
    </feature>
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            <begin position="809"/>
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        </location>
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            <begin position="18"/>
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        </location>
    </feature>
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            <begin position="35"/>
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        </location>
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            <begin position="62"/>
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        </location>
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        <location>
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            <begin position="846"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="988" mass="108858" checksum="FD528F20D999A9D4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFD8</accession>
    <name>A0A6A6RFD8_9PEZI</name>
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        </recommendedName>
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            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="7" type="ORF">BU16DRAFT_35592</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
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    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFJ8</accession>
    <name>A0A6A6RFJ8_9PEZI</name>
    <protein>
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        </submittedName>
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    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="503" mass="56277" checksum="DCEB20D7B7DA127C" modified="2020-06-17" version="1">MPSRDSLFLYLLCFIVFSFLYCMLSAFTKLTAWLRSPGTRSAARQHWTPNSPPTHPPLLTRRHSTTTMFKQAVAAHKPSQPPRKITKIDKHFSSSPPTIQNAMSPPQYIPRNGTRPLHTSTGNITRPSQAPDFGRNVAPTIGSKRNSSGLAKALIAQDNDFENATLPPRNSYHNPTYIRESPTKKMGVEDLGFEFDEDDFDSEIDLEEENPATKATVTYPKLPTVPDPPKTNYASTTISAFQNSKALPAAAASHNRRTSQDSGYGTQMLGRMPGAFHNPLPKDPVTKPAPQRLPVTELPTIPSSPPQVPDSSLPLPWSSSPAEHFKTPPKVAQIRKFGYIEPGRIPAQPVVKEEEKPRTKRRTLPWLAEDKQQAEQADVEAKAALAAKPGRGRPRKEEQNFGEFTPLPKDEAKSYPWNTTASAVKEQQKQMREVNKKKTKTMEASQSQQEENKKRRTRISKIFLSEEQQHVMSLVIDHKKSVFFTGSAGKCLRTFNLNSTYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RHN2</accession>
    <name>A0A6A6RHN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_555297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RHN2"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein catabolic process in the vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
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        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2503290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84653" checksum="6A008A17209CDF90" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8C1</accession>
    <name>A0A6A6Q8C1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_520468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8C1"/>
    <dbReference type="OrthoDB" id="3426753at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="132" mass="13569" checksum="2295966561105BA5" modified="2020-06-17" version="1" fragment="single">GNVTGALSGEVFPIGAAFETLPEAGNGIFSFYTNQVALNATSSASPTAFTSIVLNVQATLTYANEALHAFGAAQFSVADPAYLDLSFKSFVAEFEAPSYTGKGKLDIFELKTGGKRDGSPILALLPPGQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9L0</accession>
    <name>A0A6A6Q9L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_217588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A6A6Q9L0"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="98"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2488922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="575" mass="61906" checksum="52A3DE0E2C648A3E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAC9</accession>
    <name>A0A6A6QAC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_220897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2489009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAC9"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2489009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="177" mass="19221" checksum="A1AEE0785CF775D5" modified="2020-06-17" version="1">MTAPLTVQALLDRHANGIHQHRPIPTFAEIGAAGKLPHIAVVTCADTRCNPEDFLHLNLGEVIIFRNPGGSTASALPGLLAIDNLVTLEDIIVVKHTDCGATIFRDDTIRETIKQRVPDHATEVDAMSFGNITTSLEDSVRENLSFLKGSALIRKELADRCVGFVFDIKTGALNRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAE0</accession>
    <name>A0A6A6QAE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_544509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAE0"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="286" mass="29943" checksum="5745874ECAC8DCD5" modified="2020-06-17" version="1">MASMSSNAGDLFSVNGLIAVVTGGGTGIGLMIAKALEANGATVYIVGRRKEVLEKAAGEAKSGNIIPLVGDVTSKSDLDRIVSIIAEKTGYLNLVVANSGISGPSIHGLARDASVSAFRSFLWESDSDAFTKTFAVNNTAVFYTVIAFLELLDKGNKKANVVQKSQVIATSSIGAFNRVPLAGYAYGSSKAGVVHLMKQFATTLVEYDIRSNVIAPGYYPSQLTEGMLKAKEETGFTKAEVPLQRAGNEDDMAGVILFLASRAGAYINGNVVVTDGGRLSVLPATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAF3</accession>
    <name>A0A6A6QAF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_567526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAF3"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2489345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="93" mass="10423" checksum="29C7E5C24A492DEB" modified="2020-06-17" version="1">MSGRGRGGGKVLLPPINFIFKLLQSRQPVSIWLYEQLGIRVEGKIRGFDEFMNLVIDDAIEVKQATKTEAESRRPLGQILLKGDNVSLIQQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB61</accession>
    <name>A0A6A6QB61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_568231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB61"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31707" checksum="59636BF4DE341738" modified="2020-06-17" version="1">MLSLALQPRWGCQIDHHSSSWFEFEDGFSDVSGKDLYRQIWALVLRINMESDIEWPWYDLAEPKDAFDLVKHTVALTRYLLGEVLPTEELFLKYYLQEACCSGTTKLVKLLLARGAKPCCFDLNSAIRSGHLGITKLLLDHGVRIARPLVAYHGYQSASGIDGRESYRKEIINPSPIIRVVLLEHTAMLCLLRSYGVRIDHPEVGGLALKKAAEQGLESMVELLLKDGVPLHGQSCGLSPRDCWEAGEVKFRHDSVGSVFAKVAGVPVDELPNLEICPHCEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBB1</accession>
    <name>A0A6A6QBB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_531603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBB1"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2489280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="237" mass="27083" checksum="B51A7F6FB86586F8" modified="2020-06-17" version="1">MTDSTNASPPQRTTEDASPNPSDLDPSFYTWSTLFTLLAGGGKPGDRDRYIQIRDTVNEERDCKKCESYRDYLLKYSPTVTFLQSEVAKLGGNLHAGNIHCKRCTESHKGGINPKVGILLCSNHMKGRSHLEDTLSHELVHAWDYLRFKIDETNLRHQACTEIRASTLSGECRFTREFFGKSQFNITQQLQECVRRRATLSIKARPECKDDVHAAKVVNEVWDSCFSDTRPFDEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBB2</accession>
    <name>A0A6A6QBB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_518273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBB2"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2489685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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                <person name="Goodwin S."/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="357" mass="41003" checksum="A481598C6388AA9A" modified="2020-06-17" version="1">MSDLVDSGSQIANLGCGHFRLLDLPRELRNHIYYFALVREKIEIVENQEEALGILDRTTWESYSSYQAYPGKYRQRKSTYHKIHSVYNDPYVNLFLVNRQVYSEAAGIFYTQNIFRFDLIRSCLSCYIVAGFLKDRPRFAKESMRSIQLVNVGGQSRDTPVLCFESDFASQSWKRSISVLRQLTGLRSLAIQLDGWPSPETVEQWVPLDRFEILSLRSATRNIQEDREKWKQSLLASFPSISELHLVATLVIAPPRDPIRPVPKMMFEKLGRDMIGVITELSNGLCKQIDRTEEAGFKVLLQQPESWKFPHSRGKMLVECKINTKDSWTLSEDIWPGSEVEEIQTSIDGAAGENGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCT9</accession>
    <name>A0A6A6QCT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_470007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCT9"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2490215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="271" mass="30028" checksum="97129ADDD377D93D" modified="2020-06-17" version="1" fragment="single">KFSILHLYIVTFPTRTVRRLCYSLMVASTLYYLLVIFKALILCNATQLAWNNRSHCSKHLMPIYIAVGTINVVIDVIVVALPMPILWKLQLPWSRKIGLFAMFSLGGGICVISTFRIVCIARIDLQDFTHGAADLGVWSFLEPALGVVNACLPVLRPIFPRFAPSSKWKNYFSVRIRGSRKTQSSASMRQGPEIKGRGIFPGIAGSRNCINTGFRKAVDLVELLYPLDTINLVGNDIEAEKSISSRESRRSVGSEATGDSSKLSGHDEHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD02</accession>
    <name>A0A6A6QD02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_495628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD02"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="7">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="454" mass="50119" checksum="AA923E9317723267" modified="2020-06-17" version="1">MSPGQSPIAIDTSPMLPRVASIDSVSSADLDSPVSPASIVSEWSEGKQPQPGRWRHTVGIILLLATVFLWTASNFLASTIFADNEYSKPYFVTYTNTAFFIIPLFPMLLRHLYDDRFRMSTLRELLQRRVGKYKLLRDHEDEDDNLSKSDGRSQSSRRSRSPSAQMLLEEDMGNSQELSGSVHSQRPGLTLAETAKLSLEFCILWFLANYFAAACLEYTTVASSTILASTSSIWTLFSGSMMGVERFTLRKLFGVLASLAGIALISTVDVSGENDENRGTFPHKSPRELAIGDSMAFFSAVLYGFYAVLMKKRIGDESKVNMPLFFGLVGLFNCILLWPGLIILHVTGVETFELPPTSRILTIVLVNSASSLVSDFCWAYAMLLTSPLVVTVGLSLTIPLSLVGQMILDSQYSSALYWVGAVIMFISFIFINHEDKRDEDGPPLSQSDSSLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDX0</accession>
    <name>A0A6A6QDX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_470742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDX0"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41633" checksum="65F8B526167D6D4B" modified="2020-06-17" version="1">MSHLTRNPPFPRHASTLPHALRDEMTSRRLPLIYDFLTTDSDHKLRRSLQSFAAYDASSIPAQDQFNGSVYAKALTPNLDAAHHLVYFNPAIPADELLADGTDPLQSPGEPFVRRMWAGGSLRFRPGGKAVLDGRRWVCHEFVRDVQVKGREGTEKVFVGIERRMASLEELGVEQQVEIDEDVVRAKLWHASEEEFGAASVIERRNIVFMRERTGEELMVLKEAVGKPGKMLLPQHKPDCEHVLTPTPSLLFRFSALTFNAHAIHLDPSYCRDIEGHRNLLVHGPLTLTLLMDLLGNHLRVDPFQVHPSIDSFEYRNLAPLYANEPLRLCGRSIDHNKYELWAETPEGGIACKGVARTTVDKEDARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEX9</accession>
    <name>A0A6A6QEX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_531389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEX9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="74" mass="8148" checksum="5808196C213FB1AF" modified="2020-06-17" version="1">MATGKTGVALIGSGAFFSILSCNYEHLLQPFLYSESAQKTPLYFICQAVVSSMSRLVKILNFLKCEPIFLLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFR4</accession>
    <name>A0A6A6QFR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_566160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFR4"/>
    <dbReference type="OrthoDB" id="3792931at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="458" mass="52417" checksum="67B820B42D8D6B3C" modified="2020-06-17" version="1">MAYSDAAEMSGLLPEAVQQKVEQWATPTKSPHERLALLSEISKKEIRRAQVDYPGMPALEKAFVKVLEETLFYSTPESMGSLQAIAESKFATEIETLSFCGVRFTTGAVIHKSRFYVQSQRLVWEDALRRGREQSQFRESGKYLKQLTGLLARFPRLRHIRYYPVPLDRHFGQWTERTVWSDVTDWGIGKKKKIQSWERVDDDLYSRDSFAPDLKELFAALSTSGLKLETFATPFAGNEAYWHSISARNLLSIDPAYRELVFKDLKNLSCNIKQLAEGGIVVQDLLSSCPNLQTLDLSLYADYVPEHRYIDDKEFFNPLWHQGPALGTVPLPKPRDLRLTFDLGLYTRVEDILRIFTEQENGLRGIRKLGLAYVTLAKGTWPELLTQLGKVLDLEILWIISPREGRNAGRSIQGTTIPEHVLKAAAKQVKVHHDFAPFEFDWVTKGEHAQYKSFTIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGN7</accession>
    <name>A0A6A6QGN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XRCC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_122420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGN7"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="2">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="371" mass="41217" checksum="F50E3F7A11D8F0D1" modified="2020-06-17" version="1">MAAGDRHIIEIPAAAGEGDEFIIVDVTSHGPGRLDVTLLGSEGQFPYFKQIQQRKLKELRTTRKGSDEQWEAALSHLLLNEAVKAEYVSALKGVQVVYQEDGDNLKLIVRQEVATTKLKHNMGEIVLLRDEEKEIDPLDWARVAARGAAAAKDQFADLQTQLGTQQSTIDKLHAQLDDLVKAKEENDNAMLQKFTELLNEKKMKIRDQQRLLAGAKVDPKAAVTVEATREDSKSKSKSRKPAPSRTSKRKANGTARVVESESEGEFEQMQVDETEVKAEQEREEDMPEATTPDRSDDETEDEEGDVGEASTSTQPSKPVELATRTASKPEQTPELPPPRRELPFAKAKTRGQKVAPPPVEDEDDDTEDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH03</accession>
    <name>A0A6A6QH03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_126175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH03"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="556" mass="60450" checksum="38D26A8AA082F507" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHU6</accession>
    <name>A0A6A6QHU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_492768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHU6"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="764" mass="84517" checksum="DBD5BFFBC70E4655" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI15</accession>
    <name>A0A6A6QI15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_123554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI15"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="10193" checksum="F0D83E41710E4F28" modified="2020-06-17" version="1">MYLALKGMGCHLFCTPPCLVTAVHLHAQLQEQKKILMGLLLPWEKRPAGTLISFKGSCLQNRLPCYLDFQDAAIRLQQKHSLHRVILALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI47</accession>
    <name>A0A6A6QI47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BU16DRAFT_565465</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI47"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
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    </dbReference>
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        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
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    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025352770" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="312"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2491769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="821" mass="93355" checksum="F28928405423E7F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIG5</accession>
    <name>A0A6A6QIG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
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        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
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        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
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        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7902" checksum="AFD39AA715A209C9" modified="2020-06-17" version="1">MTKYERARVLGTRALQISGNAPVLIDVEGMTDPLQIAIKELREKKIPLVVRRYLPDGWYEDWTCEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIJ1</accession>
    <name>A0A6A6QIJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EF1G-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_574162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="domain" description="DUF7703" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
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        </location>
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        <location>
            <begin position="190"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="23942" checksum="7B201B14D5D1A607" modified="2020-06-17" version="1">MTTASFHFYNGHQNATAVIVVVCSAISLYNALELLLLILTTFHVYRGLYFSSLVAASAGIILYVLGFLFEYFKLAPEAVGIAVDTLGWTLMVTGQSVVLYSRLGIVMGEGHRRGRVLRAVKWMIILDALIFHTMTTVVVFGAHFSTSPFYTAYTAIEKIQMTAFTLQEFILSGLISTTCCRSCARGGGPSSSRRLPRTRTPGPRSARRSASCTSCLVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QN59</accession>
    <name>A0A6A6QN59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_73437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QN59"/>
    <dbReference type="OrthoDB" id="3796777at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025365086" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="55128" checksum="1061F4E304B47491" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNC5</accession>
    <name>A0A6A6QNC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_465307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNC5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="52624" checksum="AD9450FF85DCC2FC" modified="2020-06-17" version="1">MAPARTTDVDFTQFYNIVNGEKRSSKEFLHGFNPSTQQDLWDVPIASPEDIEETIQAAKTAFKSWSKTAMDERSVLLKKYAEAIKPYLGDLGDLVMKEIGKPVRFAHHEAQYAYSELIKSANLRLEDETVQGEDREYVLRYQPLGVVAAICPWNYPLGQATMKFLPGLMAGNTVIVKPSPFSPYSALKLVEIAQGILPPGVLSVLNGNDSLGPLLTTHPGIAKISFAGSVATGKKIAESAAKTLKRVTLELGGNDATIVCKDVDIEKAAPQVILGAFFNTGQVCAGTKRIYIHEDIYPQFLEAIAKAARSFKVGASDAEGVTIGPVQNEMQYNKVKSIFDDAKTHGYKTIGNGAVIDKKGFFFEPTIVDQPPANSRIVTEEQFGPIVPSMPWSTEEEVIELANDSEMGLGASVWSNDLEQATRIAKQLDVGSVHINSMEKVSIKIPFGGHKESGIGVEGGPGAIKTYCDLQVLHYYKAGDAQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QND2</accession>
    <name>A0A6A6QND2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_528081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QND2"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2493885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="30417" checksum="CF70C94BF1D35B86" modified="2020-06-17" version="1">MSVDPRRRVAPPPPPSPIEAHPDSTKMALAGSNNTKPSTGAVADEGFKLRFCTVCASNQNRSMEAHLRLASANLPTISFGTGSLVRLPGPTIKEPNVYAFNGITYNAIHNELQAQNPQLYAANGLLPMLARNLTIKSYPERFQDWVPGKARLDHNGDQGFHGTEGGVVDVIITCEERCFDAVLEDLHNKGGLLNRPVHVINIDIKDNHEEASVGGGAILDLALRLNEGAAKEREVYGAAGWDSSGKSREGFDEKVPEIVGEWQERWPNYPALWTLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNL4</accession>
    <name>A0A6A6QNL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_619053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNL4"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47343" checksum="90B51F3F33FFCE7E" modified="2020-06-17" version="1">MMLDLFPTLVGIADSKTGNIAAAVVFVIVTLVYVRSGHYELSDCPGVSKTFTDEVNCRRVLQAKTTNDEHKDLRIALTSRAVPNQRLTVAFGIDNAFTTTSIEKRKSFKDQSISILHRPSLNSGWEKLHFGLRIMIRDALIDKSILLVPLVQSLTLRITLGVLFDLDPVQIPIGVAEELASDINDIWLASKCGSIPIWRTQTRTHMLLRTLISSRNPLDAAENPMNFILPAYETLWRVVLRCFIEIAYRGPRANRTIWRQAIHESLSTNKDESIALAKVSADNIAREALRLYPPTRRVYRYESNLNTGLPEVVAADIEACQRNETEWGADAKTFNPDRWTTIDDPAKRLLAFGDSPFRCPAYNDFGFRMIILLTGALSEGVGEDWELQSDSGDELPEWGTPLCSARKAYSQVRLQDMRSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ15</accession>
    <name>A0A6A6QQ15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclochlorotine biosynthesis protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_462753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQ15"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF12">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2494578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31301" checksum="5339619D639C1611" modified="2020-06-17" version="1">MISSSSDFEKLQSPQFSNRRKHSISANIVHWTTHVISVLIIFGLILNLILRDITKGDTKPEHKSKTQGVWTPADEALGDTSHTEIFQNSFWEDSPYKGPPTEEILARWHRITHTGPLNITREEIEGLELSTDAVQYPEEFGGGYVAYLESAHQLHCLQALWEDHHWNTKPHLRHLFPVLATKLATEPNITEAHFEHCVDVLRNRLMCTADASLVTFRWVKGVSGPYPYFNTKHECRSYEGLLGWDRERRPGEKFPDGYPWPKPEGVGELERAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQF0</accession>
    <name>A0A6A6QQF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_43862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQF0"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42306" checksum="4EA70F20BF733EEC" modified="2020-06-17" version="1">MVLPILGARSAPWMSNFVAVSVIGVVLFVTVLGFWAFQPPMPRPGYHGGTTVEVTIPVEPSGPVSIQEVLRLLYAPLKMKPTTPSFTDDLGRSYKLPANPLFPNPLGKDLLVVDLETRPLDKNGQLMHKGAFKWGDLDYLSGGVMNHYTYAMIHGYDYKFVQAASFDDRHNTWIKPSALANLLKHYKFVVFLDADAAFHQMQMPMEWLLNYWQITPEISLAMPLDPSGPPGTNDDRFNRTLTNTGFIVAQQSDRTQEILKAWHECPDDTRYPDCSQWKQPRFHEQSAFGNYIRYDYEDNIKELPCTEANGYPSENAQCEGVFMRHYWYGKERVRDDLANSTMEAIMAPIQKLYMDHRKDIITEQAKNEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQN0</accession>
    <name>A0A6A6QQN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_591336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQN0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="170" mass="18013" checksum="B15CA9A5B97286FF" modified="2020-06-17" version="1" fragment="single">LVCLVLLALLLIFLAFDPGAVGVFRLGLLRLPVRSTLRGWRSPLLTVFRFVPAGEPGPESLRSLSLSSDGNGGGFFLIGGFLRVWGLLAQAAAIQLTPQVSEAIVLVRIVVLMAHLHAASGRVNLETLSAQLAILEGNFTPSPMESVVASLSEFFLADGAVEHVSLKQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRZ7</accession>
    <name>A0A6A6QRZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF567-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRZ7"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="195" mass="21301" checksum="222CC215B3A092DC" modified="2020-06-17" version="1">MAQLPPLSRDIGIFPPYIAQQSETLVLKEHVLSLSGDSFSIKTTDGRAIFQVKGEVMSLSGRKHLMDMSGSPIFDIRKEHLTLHTTYYGEDPSGNKILEVKSKFALLGSTAYGTFTSLSGKAEKLEMKGDWLSTSGQIVDTSTGEVVATIDRKLLSGKDIFFGQQTYALTIAKGADMALMVAMCIALDEKNEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS66</accession>
    <name>A0A6A6QS66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_527893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS66"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="15893" checksum="F256EF4F575E3941" modified="2020-06-17" version="1">MSTATHSTQTGSCQCGAVSYNLTGTPLSSFLCHCTNCRKFTGSTYQANAMYAGRDSLVVTKGKDNLSVCAYNNTTSGNTIRRHFCKTCGSPLFIYPDANAGIVVVMSGGLDDPAAFAPTRECFVKDRLAWVTPIEAAQFETVQSLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QS90</accession>
    <name>A0A6A6QS90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_511131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QS90"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
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            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QSA9_9PEZI</name>
    <protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <begin position="24"/>
            <end position="46"/>
        </location>
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        </location>
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            <end position="116"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495301.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="17067" checksum="05AD2D2654C05D80" modified="2020-06-17" version="1">MSCYYGNNGQEYCQSSAWDNWVRWVVLAVVVIGFFLLFILCSCLTARRRRRAGRQPFYGTGWAGGRVPPGHNPATYNAQPYYSNNNNQPAPPYTAAQTENYYGNGANQGYYGQQNGVELQSPQPAHTPYRGEDSVYTPPAGPPPNKQHDGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSB7</accession>
    <name>A0A6A6QSB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="159" mass="16947" checksum="43CE2457E8C2543A" modified="2020-06-17" version="1">MTPSQQQKPVWQAASQGTRGQSMIDPDVLSGIEFGLGPPGGALERTSLAAFPAFRALPSPRLLRLNQFAPAAWPRATTGAVHRSAAGGLLHSCYPYSLAPPPAAPARSAVSPLSLAIPYSPSTPRPPCPCEHSCTRPPPSGLYDLRRPKKHSRPAEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT32</accession>
    <name>A0A6A6QT32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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    <organism evidence="9 10">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2495282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT32"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450IV"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2495282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="531" mass="59632" checksum="7A51D2510F64E0DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTA9</accession>
    <name>A0A6A6QTA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="78" mass="8207" checksum="7AEDB0D3D75992B6" modified="2020-06-17" version="1">MSLVSIAVHVFKAQEVSFWSNLTATCGLLMTLKDWIFGAHGLCAGAVVLVAGHFDSKAARLSAGMSATRHPPLLVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU91</accession>
    <name>A0A6A6QU91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_459495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2495756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="95"/>
        </location>
    </feature>
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        <location>
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            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="385"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2495756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="490" mass="54882" checksum="17CDA987AEF132C7" modified="2020-06-17" version="1">MKHGYISNDVDIAAAYAGQLDGENAYTRKEQVRLRWKLDLRLVPLLWFNVTLGAMDKVTTSTAALYGMKKDCNLTGDRYSWVGSAFYFGYLFWCLPSGSLLQRFPIAKLMFVAQLLWGVILIGTGFANNFATLIALRVLLGVLEAPIVPGNFLVLGMWYTRREQPLRTGLMYTGLSVCFTGPIGYGIGFIAGDHAWRSMFWITGAMTIVWAVIIGVFLPDNPVNTTFINERQKAILVERLRADQTGVENKTFKREQMIEALLDPKTWLMFLFNIWISIPNGGLTNFAPLIIKGLGYTSQRSVLLTMPTGIMQTASSYMCNGGVFLCAKYLPKYQLRGAWVAFGIIVGLISSVFLYTLPLHNYNGRLAALYMSYFYLGPYIVALGINTANTAGHTKKVTTNALIFISYCVSNIIAPQFFKAEQAPLYPLGMGAILGSYVLSLITIAAYCGYCKWENTRRDRVDLAKDARVHADTDFKDLTDKQNPHFRYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUA3</accession>
    <name>A0A6A6QUA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_508365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUA3"/>
    <dbReference type="OrthoDB" id="5403280at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2495769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="496" mass="53440" checksum="09ED7B1D180B7475" modified="2020-06-17" version="1">MEHIPAEKEQSESPTHSPEDSPEADDPSNPFNWSPTKKWSVTLTACYVTLIVGFNATALTAAVSQTNAQFHVSDASFPHSVWPVTAWNTGGALAPMVVLPIMEDYGTRPGYLITYILFFIFVVPQAVAQNFATFIVCRFFAGCCGAVLQDAMDGIIADIWAEATQRSLPVSCYVFALLAGVSIGPVVGGAIVESLSWRWIFYIQLIIYGGSAPIIFLIFRETRYTVILTTCAKRNHEPLHSPQPTEPGSKQHTKLSTLKSFLAGNILRPFLLLTTEPVVTSFTLLSALSYGLLFIATQSVPQVYTALYAFSEPSTGLIQASIVVGEILGFLACAFIGDPYFTRASAGTARIVGGDLQLPEVRLYLAIPASFLGLAGGLFIYGWTSYANVTFWAPAIGLLLVGFGSVVVMQAIMIYITDAYAKYAASASAAVCFGENMAAAFLPLASQSMYSNLGFHWASSLLAFVAVVLSCAPVVLVWKGKVIRGKSPFMREAMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUN2</accession>
    <name>A0A6A6QUN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_562287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUN2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="199" mass="21864" checksum="1D21C74E804151B4" modified="2020-06-17" version="1">MERQRVVVPMLDEPPRSVYAPSRHCLAAHVEPEPIPSQFFATSRLSHRTQTPNTAQATPIHALSSALLSSPCETGLNPRRRRRSRADDLGCFEPAYRFRVLSTSPHIDGTFIHISHFAHGPRVRVAVHSHVAAPTIIALLLKLPFAVCVVDRRKHSGLGTGDPPEPQWRAALPTRLRAPPRDISGTSIRHSGTSARGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV11</accession>
    <name>A0A6A6QV11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_526555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV11"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2496026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="226" mass="24931" checksum="6F2E7BD3DCB35030" modified="2020-06-17" version="1">MTSFASSNTTLAPSVAPSTSSSTTPSPTDPTAFAYPALYNYPPFFTLQPILPTRHSQLLSWSLLIQAYTRHHALFSLSLIDALSTPLFHNRPLHRRLSLRDARAVIDYMCSKDGDMRAEWITTPSTASNVLKKSNPSGGDEEGGGRFWVFWRKPDEWANLIESWVDSTGQKGVVLTLYELAEGDATRGQEFHGMEAELLSRCLGVSVKRGRAQVFGAEGGEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXW1</accession>
    <name>A0A6A6QXW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_343709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0M3"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="99" mass="10804" checksum="34FD4744B5483EFB" modified="2020-06-17" version="1">MSQTKSQEKQQNSAQDSNAEGSDSDNDDQQLAAPTAPQQMAKPRGGSKRIVPVHQSRIADRPAKVGEKDSSLKIKIELDLEVEVEIYARVKGDITIGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0P8</accession>
    <name>A0A6A6R0P8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_333381</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0P8"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
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            <end position="258"/>
        </location>
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        </ligand>
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        </location>
        <ligand>
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        </ligand>
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            <position position="290"/>
        </location>
        <ligand>
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            <label>1</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2498066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="323" mass="37374" checksum="A0C225AF9DD91536" modified="2020-06-17" version="1">MAPALLETPNINETFNDRDGLALEATSDAIDEVNVLKAALKVKKGTATQEEKDIYEASQFDAEKDKTQFRQYEEACDRVKNFYREQHEKQTVAYNLKARNTFLSFTRAEMTIWEAMEKLNTLIDESDPDTSLSQIEHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLLFFFGAEGQWDVVGDTFPVGCAFDRKIIYPDTFAGNSDSTDPIYSTKEGIYTPGCGMDNVMLSWGHDEYLYHIAKAQSTMPDEALAMIRYHSFYPWHSQDAYRWMMNEKDEKMLEAVRAFNPYDLYSKSDEVPKAEELKPYYMELIKEFWGEGKVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1I4</accession>
    <name>A0A6A6R1I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_536578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="210"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="701" mass="78650" checksum="E827B247F3DF0BD0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1I5</accession>
    <name>A0A6A6R1I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2497703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="319" mass="36159" checksum="A6F54164DD9B69D8" modified="2020-06-17" version="1">MASASTVKTRFLIISDTHSDQPFRQPMPKADVLLHCGDLTMIGKLDEYQSTLDMLRDCDAELKLVIAGNHDISLDEEYYGRRGKWMHRRGEYDANMPALAKAMWTGEKAQRAGVTYLEEGTREFTLTSGARLRVYASPYQPEFCDWAFPYNRHEDRFNTGKHVHPDATRIAQNPIPDFPGVDVLMTHGPPMGILDKTSRNEPVGCEHLLRAARRCKPRLHCFGHIHEAWGAERVTWNPNTDLDDDWKKHVVAVAPMTVDEAEIAEKKAAFVDASSSSLPLEFGKETLMVNASIMNLRYKPMQAPWLVDLDLERTVHGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1K2</accession>
    <name>A0A6A6R1K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_334590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1K2"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="128" mass="13298" checksum="67F4BE15E7879AA3" modified="2020-06-17" version="1">MRSQVPAHAAPLAAGNQQTPFSTGRMASRLRTHASHTVSSSTNRVVCGSKREYQTRVSVGVSPATVTSSFGHGPLRGLCSSATTPKRDASGADCETSQAYAILIQLLLKSQAVGRLAGMGGETAKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1M6</accession>
    <name>A0A6A6R1M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_456027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1M6"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2498406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="189" mass="20210" checksum="586B70F80C147A5C" modified="2020-06-17" version="1">MAENAPPPGSGGHRPDASAGMPYYEKLRRDLRETLQKKRQLDNSLASLEESIYKAETSYLEETSAGNIIKGFDNYIKGSTGTTTAGGAGPGTSTRRKAMINEGDRIFSRSSASFMRDSPTPNSAQTTPSHAPTPTSSFPSGRESSHPTPNGSTSSKAVASKKKKAPEKDDDETDGKPPLKRGKITYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1N0</accession>
    <name>A0A6A6R1N0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_558361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1N0"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="99" mass="11331" checksum="2E1A948C16EBD7FF" modified="2020-06-17" version="1">MLFFSFFKTLIDHEVTVELKNEISIRGTLKSVDQFLNIKLDNIQVVEEIRWPHLSSTKNLFIRGSVVRYVHLPSSIVDTALLEDASRREATAAKEKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1V4</accession>
    <name>A0A6A6R1V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_558574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1V4"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="628" mass="68372" checksum="BBCE5B5458901DE2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Y1</accession>
    <name>A0A6A6R1Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_548426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1Y1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2B1</accession>
    <name>A0A6A6R2B1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_302049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2B1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="365" mass="38673" checksum="149B636E2DE9C3BE" modified="2020-06-17" version="1">MSPHNDAPSPNGSFTNGNSFNGLSVRSQAVQHIFNQAHFDNFETSSVESMDIHRPLLPGIYVPTVAFFDSATEDVDVKTTSTHAVRLAEAGVAGITTQGSNGEAVHLSHKERSLVTRTTRKALDDAGFGYMPIIVGCGAQSTKETIELCNEAAADGGDYALVLPPGYYQGLFSKDTIVSFFKDVASASPVPILIYNYPGAVSGLDLNSDAIIELAQHHNIVGCKLTCGNTGKLNRVAAATRAATMSEPGSGFMCMGGSVDFTLQTLIGGGSGVIGGMANIAPKACVKLMNLFEAGELKEARRLQAIVARGDWAAIQGGIIGTKAALMAHFGYGGYARKPLPKPSKEETRKWRDAFEELVKLEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2M1</accession>
    <name>A0A6A6R2M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF924-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_558579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2M1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="270" mass="30101" checksum="ACCED34E86C3F92E" modified="2020-06-17" version="1">MSTPRAFTLSKEVFNPSLYKLVQSTWFGGLPEGARAPTKEVAKRWWGMGAVPEEKAAFDTVCSSNFLSALESIGPEKFPLSQVPSSAIAEPFLREISEQSSQDDGAESASTALSLILLLDQMSRNIWRTPSTLPLVYNHYDTIATAIMTSLLSPNSTLPRLDKHPLYRLSAAHRFWFYMPHMHSESRELHHQLAGVLGEFRSELVDAGTECKDSLGYFDRAAGFEEIHAKIVERFGRYPHRNEVLGRESTEEEAKYLADGGETFGVGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2N9</accession>
    <name>A0A6A6R2N9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_558686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2N9"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="316" mass="33814" checksum="08EA160D4A821645" modified="2020-06-17" version="1">MGGRTANKAGYFDKLKALLEEYKSIFVVTVDNVSSQQMHEIRQSLRGEGVVLMGKNTMVRRAIKGFIAESPEYERILPHVKGNVGFVFTNADLKETRDKILSNRVAAPARAGAMAPLDVYVPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEGGTKVGASEATLLNMLNISPFTYGMGISQIYDNGQTFASDVLDIEESQLLKAFSSAIATIATISLATGYPTLPSVIHSVVNSYKKVLAVAIETEYGWDEIEELKDRIQNPDKYASAGPTTTSGGGDAAPTSGSGPAEPEPEAEESEDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3F3</accession>
    <name>A0A6A6R3F3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_523628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3F3"/>
    <dbReference type="OrthoDB" id="3910212at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="576" mass="61572" checksum="7E47A9F8E7DE3CE8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3I6</accession>
    <name>A0A6A6R3I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_536841</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3I6"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="193"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="423"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2498864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="553" mass="59888" checksum="2CB682E3D77FFC87" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3N5</accession>
    <name>A0A6A6R3N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_457233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3N5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2498007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="33840" checksum="0A8C54A72FE8A63F" modified="2020-06-17" version="1">MFGFGGGITFKPDTDIPDLSSKVILVTGGNNGLGKESVRQFAKHGAKVYMGARSEKKATDAIAEIKQSLPNANIAFLEFDLTSFDSLKSASQNFLAENDRLDILMNNGGIMAGPRGVTKEGYEMQFGTNHVGHALLTRLLMPVLEKTAAEQDSDVRIINLTSNSQELFAPKAGLLLDKVKTDMESTGPLTCYGHSKLANVYFTKGLAKHYPQIKSVAVHPGGVQTGLSARLYATYPRFKPILLLMRLAFADVSVGAHGQLWASTATSADVQNGALYYPVAKEHEGRPLMNDPEMVDSLWDWTETELKTHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4R0</accession>
    <name>A0A6A6R4R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_603342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4R0"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="229"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="545" mass="60938" checksum="17A0696C093EC1A9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4S7</accession>
    <name>A0A6A6R4S7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_557857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4S7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="333" mass="38284" checksum="0B4B83910559BF10" modified="2020-06-17" version="1">MTKYEDFLSTDIVDLDIETLPDDDQFCGICRFPYEPNASNTVPEDIDTDNLACLRELPWTSTYAHGDAVLLPCNHHFDAECLLRATEIGNTNLCPLCRCVLFLPPFGMRLDSAENPMALYGDLLALNALPTRVFLMERPSAEPDRSEMMKVYAHSMTGRLLEMMAEVAERFDRTGSPKASWTQAEKDVARVLLRRAFVVPHDLGVESRRALRATPWLPPFLRFLADARVYRQFNRWSSVLRRLNESCKTPRELLEALNEVILQPLHDGLFNTPRFHRWAALTTRFFVSWHVEQQSFTNEEVLRLANLIAQTRGSGPWGDIGEYEQLLRWYACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4Y5</accession>
    <name>A0A6A6R4Y5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_615549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4Y5"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="313"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2498517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="450" mass="46890" checksum="EF6D75AA952B73FA" modified="2020-06-17" version="1">MASPSPPKPWERGGGGTSLAGTTNTPAPSATTTATSTSSTSPPPLPELPNTLNSVVNRNSSNYSTMNQNRLGSSPYGYGSSPYSSPYSRLGGGLGGGLGGGYGSMYGGGMGGMYGGMGGMGGMGGMGMGGMYGGMGGMPGDPNNPASLTQSFSQSTQATFQLIESIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGTLRQTLGSVLGIFTIMRWIRTAIAKLTGRPLPASSKELTPAGFAAFNGRMPDGSPAAPKPSKKPFIMFMVAVFGLPYLMGKLIKALARSQEEEAKRQMEANPQGYVDGQPLDPSKLDFCRLLYDFTPDTNMASVQGVDLAVKKGDLVAVLSKTDPLGNPSEWWRCRARDGRMGYLPSPYLEPIQRRPAQAQITSGSQVGSPAGSRAQTMTSSSGSRAATMTETTAPEKPPQVAGKAGDIGVESFQKGQFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5H3</accession>
    <name>A0A6A6R5H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_615728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5H3"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2498717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="19649" checksum="F5915F4720E702F2" modified="2020-06-17" version="1">MVTGPLVEMLARNSKFAQSYQAPPGLVQMASTMRSTGAGVVVISCSDPRLNPYQILGIDPTLKATMVRNAGGRVFDAIRTLAVLQTIGAPGTIVVMHHTDCGMIHWHDADVKEALVEVAPEEKESIEASKFGEITSSLEESIREDIGILRASPLIKKSTQIVGVKYDISTGVLSVVDETKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5Q1</accession>
    <name>A0A6A6R5Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_557406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5Q1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="149" mass="16666" checksum="009FA334E0B40418" modified="2020-06-17" version="1">MSLPEPRDESVDGGDGRRDWRVGAGTRATRQLQRPREKTTEGRAQGEHLLRSAKPMADLRPEKNLRTDDTGGGEEVAVDSVQKHGRDGQTRQQIHAQGAVTGPTCRSDTNREHYYLHVEMRQTAQSVGKRQRDPLTSTCGEYGQWAWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5W4</accession>
    <name>A0A6A6R5W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_615848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2498867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2498867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="112" mass="11077" checksum="150C14F9CAE7FC11" modified="2020-06-17" version="1">MKHLAAYLLLGLGGNTSPSAKDITEVLESVGIEADSDRLEKLLSELKGKDISELIAEGSSKLASVPSGGSGGGAPAAGGAGGAAAADEEAAAPAAEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6F2</accession>
    <name>A0A6A6R6F2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_557633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6F2"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="658" mass="73262" checksum="A9D246C442FBB374" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6M5</accession>
    <name>A0A6A6R6M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="478"/>
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        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="533" mass="60512" checksum="15FB252CEFB2222E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6Y5</accession>
    <name>A0A6A6R6Y5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21578" checksum="D6D983A87F34DFA9" modified="2020-06-17" version="1">MSGLEKALFNLKFTTKQLNRQAAKAGKDETAEKAKLEKAMKAGHNDIARIYAQNAIRKSNEKLNLLRLASRIDAVSSRVQTAVTMRQVTGSMANVVRGMDSAMKAMDLEKISAVMDKFETQFEDLDVATGYYENATSSATAVGTPQEDVDRLMNQAADKAGVELHQDLEAATPAKTKVGPTEQEEEGLNERLRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R711</accession>
    <name>A0A6A6R711_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_534937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R711"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="577" mass="58970" checksum="9A166A252F835D9B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R834</accession>
    <name>A0A6A6R834_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_452529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R834"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="104"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2500769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="464" mass="52502" checksum="6AF9BEFFF3DAD8E6" modified="2020-06-17" version="1">MAGGASRWANDKEDEVLEAQRKKEKEEKKRAKLEKQRKLEEAEARRKQAAEPESTQGLQNEVERPVKRRRLSNERDDGDVPDQPRRLMRFVAPEWGPCRHVDNFERLNHIEEGSYGWVSRARETATGEVVALKKLKMDNLNDGFPVTALREIQTLKESRHRHVVDLREVVVGDTLDEFSSVFLVMEFLEHDLKTLQEDMAEPFLPSEIKTLLIQLSSAVEFLHDHWILHRDLKTSNILMNNRGELKLADFGMARYFGDPSPPKMTQLVVTLWYRAPELLLGTTTYGKPVDMWSVGCIFGELLTKAPLLQGKNEVDELAKIFELCGIPTEDSWPGFKRLPNAKSLRLPRTPQTQGSIIRSKFPFLTGAGAALLTSLLSLNPERRPSAAEMLAHPYFKEDPRPKATAMFPTFPSKAGQEKRRRVASPSAPQRGQAPKIDAGEVDFSGIFAGRDLEESGAGFQLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8G1</accession>
    <name>A0A6A6R8G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_255192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8G1"/>
    <dbReference type="OrthoDB" id="5414285at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2500684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="29266" checksum="F5CCBC90A064F882" modified="2020-06-17" version="1">MPPTLTSLTSRTLSSLLLAARATKTPTPAKIRPKKHGISGWAVFLIVVLVLLILAAVAWVVYSRLRARRLGLPPPPLNPFASSRSGPSSNYPAPAPGGVKGWIDTQVRKFKNRRYATGAYEEPTGYGGAGGAARGRGAGRGPLDPDEAWDAHVGNEAYYEEQELGLHAPAPGGNAAYGGPTGYTGAYGGDGVGGAERGRSRTRELDERYEEEMHGGAKHSTNPFGDDNAVSLRGVSPRPLETERTGGAYGAPAGAGHKKTGSGDSSPTERRSMFRENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9H8</accession>
    <name>A0A6A6R9H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2501299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="451" mass="52219" checksum="4B30EBC468E25A1D" modified="2020-06-17" version="1">METESSPTEPFPLGNRVIHANIQSIEPEGDDGSPDNSQGVLSDEQKNARNASSEMQLWWDEAIAKNMELPDYYRNVSVLIIKWDDELDELKTGPEVIELDALFRNSFHYNTRIVELNVAKKPQHQLNRHISTFVEDCDGENNLMIVYYTGHGVYREHERYLELTASTKLSVKRGLNIAAQANWDKAEEALRDENVDGDVLTILDTCFSSNLTKSGREDTRTYELLSACGLDGTTARPGENSFTRALIDSMKELLVEFPDRSFTTFHLNQRIILHPNRRDTPSLLWDRLRHHERHIRLCPLKPESDQTRKRRPPPGGYLTLRFAIRDEKLNSEQIQLLTRHLSEAFNNKAMIGVRSIDWMGIKPARVRHFRRAALALQACQQWKKMVKRRRLQRMQQHPTPESDQTFLGPNRKRTQDEMSFEPADERESKRDKHSHHPRVQCPMISPLTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9J7</accession>
    <name>A0A6A6R9J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_534010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9J7"/>
    <dbReference type="OrthoDB" id="10669199at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="433" mass="46772" checksum="8169E8255B4DDFB5" modified="2020-06-17" version="1">MGMTTTSNSDDIEEFLEDMQEAAAGSSYRRRFPTYVPMRTRVVFVPTPVYVVPSGPIRALHSARFNGGRPLESAPRSIVSSSYHEGDRDRSEAGGASVASSLRTHGSRSNTRGNQEATDRAASRSGNSRASRSDASTARPQASSRSNTGGSRTGSRATSRANVTPARTTPAPPVPSMVGGAARSLAGSVRPDDSVTYASSDRQHQSAAPSRTNSRVNDWASQVSASQAGGSRRSTAGYRAPGAASSVAASRVVTGRRRELDLVRGQRSSNLKPNVLLLNQPLSNIFLGNTIVPPSHSMNINNVSYTHLPYGNSENSSSSSSEAEEPHFSSLSYTSAITNIPRQIDILLARYGGRTHFPELRRNPHFRILAAPPGQLSLHHYINQGYLDRNSRNFDRGLDPSDGFFEPTNYRAIVSELEALPGFLRNSRRTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9L3</accession>
    <name>A0A6A6R9L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_452018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9L3"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="252" mass="27181" checksum="33E45C1859A0602C" modified="2020-06-17" version="1">MRNVLIVGATRGLGHSLAAQYAKKGMTVYATARYSIPQTPAHGIHWIANVDVAHEGAGRRITAQWQEETKIDVLIICAGYFAMETLEEPHWDKEVTMYKTCAIGPVFLVHHLLHAGLLKRNSRVILVGSESGSVTLRHESQGGGNYGGHGSKAALNMVGKLLSIDLKPKGIAVAIVHTGYLRKENKEGYFEPGSKGAVKPGEAATGLVEWIESFDMSKTGELWAPRGAGDINSAEVVLGPLDTLPVPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA15</accession>
    <name>A0A6A6RA15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA15"/>
    <dbReference type="OrthoDB" id="3944862at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="707" mass="77096" checksum="6C2DCEE9EC6ECD0B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAS7</accession>
    <name>A0A6A6RAS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_534172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAS7"/>
    <dbReference type="OrthoDB" id="3794485at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="523" mass="58017" checksum="C21D381C446C09CB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC98</accession>
    <name>A0A6A6RC98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC98"/>
    <dbReference type="OrthoDB" id="3860514at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="349" mass="38133" checksum="1819E3B78310809B" modified="2020-06-17" version="1">MARLSFTRYLGLEVKFNHVRTPEHELYLRDPPLPPPTPNIITVTDLERALFVATTPRPSPVSLPFKAKETPQAGPTDPIMASALALSAADLMPLRAWERTDSPLLALPRELRDEIWAYSVDSGPALRVSASRKHGEKLLMMVSGSDVTTTAGNGVETGCSLVLVRKEVRSEVLPLIFKTSLEGLDWAHMGRMLSSLLPLVPNATTPPTASAVTPLAADAATTPALPRPLLEHAGLYIRHLIMRSNDDVLTPATLAAILRINHLQTLTLVGTRCCHVHHFLHTTSSNACDHRTCPVFLQRQAQTTALVVQLRTAGVDLKFKREGDELWPRSPGAVTRLTSAGRKISVVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCD3</accession>
    <name>A0A6A6RCD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_11588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCD3"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025353933" description="glucan 1,3-beta-glucosidase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="85"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2502528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="442" mass="48597" checksum="F1B10FC66CF96E25" modified="2020-06-17" version="1">MVRSFRTAATAALSLCATLSNAAPMTPVKRDLKFDYNGEKVRGVNLGGWFVLEPWITPSIFEEWADSNTVKDEYTLTQTLGKTEALSRLSDHWNSWITEDDFQQIASHGLNHVRIPIGYWSVIPIDGEPYVQGAYDVLGKSLDWAAGAGLKVMIDLHGAPGSQNGFDNSGRLGAIDWTQGNTYQQTIKVLNKIRDDHASHSAVAAIELINEPQGWDLNMDTVRQFYMDGWGNLKNSDVAVTFHDAFQGVTNWGDWGSGMSNLLLDTHHYEIFDDDAVAQSPSDHIATACSFGNDMASTGKWTIAGEFTGAITDCAKWLNGLGIGARYDGSFSGSTSHGSCDGKYTGTVAGLSDADKSNIQHFINAQLDAFEKATGWIWWTWKTESAPEWDMQDLLAEGIFPSPVSTRNSKSLYPKLFLLCSRRDVVRVETMVVGLEVVVDPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCU1</accession>
    <name>A0A6A6RCU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_545672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCU1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="196"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2502212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="697" mass="76610" checksum="03D39B72F21A3A36" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RCV7</accession>
    <name>A0A6A6RCV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_474916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RCV7"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="266"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2502595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="584" mass="66135" checksum="95DCFFCB3C5590B4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD16</accession>
    <name>A0A6A6RD16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_522313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD16"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025538715" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="181"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2501337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="610" mass="67537" checksum="6F6D853E35B9373B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RD23</accession>
    <name>A0A6A6RD23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_532923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RD23"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="141"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="371"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="371"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2502579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="89787" checksum="22D71D3824CEA4C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE35</accession>
    <name>A0A6A6RE35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">BU16DRAFT_521656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE35"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2503025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="187" mass="20343" checksum="9A2CE37C164D51C8" modified="2020-06-17" version="1">MALLQRGSADASAPPPAELPAPASRPSADAASSSSSLTSPRSRKQLGLFVAGASFFMISTIITRRSMVRRYKQVQPTFYQPNTKPNLSFNAGLEAFEALNIATMNVASFSMMVAGGTLWTFDISSMDDLRRKIRGGLGVDGTGRSEQDAEEEIEEWLATVLARKDDKERKRKGGADEQRTNDRGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RE63</accession>
    <name>A0A6A6RE63_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RE63"/>
    <dbReference type="OrthoDB" id="3792649at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="307" mass="34143" checksum="ECE68463CB8F01CB" modified="2020-06-17" version="1">MPQTPKSTQSALAAELHNSTYSPLYTLPAELLYLISSFLSPLEIMSTRATSRKFSVLLPPPKLTTPLRRQYRSLVRRSHFRALCAFERQNQLPPDILVCSACLQSHPASAFPLSEQTKPPARRQCAGSTRVFRVCAHKAVTFAALEVGGAESMRCAVPHGAVRGREAREVVSCRVGGDVVVVWECVLMRVAAGRGVWRKEVLEAVGRVGEGVCPHLRMGVDMKWEAGRGMLGKWFRGWRVGDWGLVGSCEEGGCETSFYVERKRCKDLKDGEEEMAEIVFCVERHLGPLRDAADPRWSVQTVDMHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REG0</accession>
    <name>A0A6A6REG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_554196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REG0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="13203" checksum="D3575DF5CE3EBDD0" modified="2020-06-17" version="1">MALVCAGVGSGLMGEPFLHAESANKANFVVGYVDPAAGVHASCTSHSRGHPVWVPNRRTCQPSVTWAKTPQESRDFSTVRHLGKDTPNSSKGPVVSGHGQRHPRLVQESSDLSAVRHLGKDTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REK1</accession>
    <name>A0A6A6REK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6REK1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2502170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="230" mass="25567" checksum="8771D78C4B074444" modified="2020-06-17" version="1">MEVLGTGSAILAVAELSLRLFEACDAYYQTVKGASNEIKTLRDHAGVFNTALKALNALATSSDAGKVPILAEWMQDGGPRDECAELLTDLLAKLAKQGDRKEKHSWLKNLDWPLKKEDMENGINTIGSHRESLVMALGSDNLTVSLDTNRVATMIRDDIAIKERENLLQKMLKWIPAVDTSVNHKEARRKHQAGTGDWLFQLEEFSKWKTTRGSVMWLSGMLGCGKTILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF20</accession>
    <name>A0A6A6RF20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_612017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF2502340.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="364" mass="38817" checksum="8A9EF2B03F2843F4" modified="2020-06-17" version="1">MATPQAQAPPVAIPLDQLQSMVNAVLMQTGKIFKDPKLASSAKNAYNLKRIVPAAVDRFQDSLDELEDEIHRAQAVFRRDLALIRADRIKREQAEAAERQRVAAEAAYKASKPAETQSKPDDIMRGVEDLLNEPNPPAAKEKSPEAPPPPEPAVKPQPPPSSSVAQVSLPAPTAPMSHPAPINTTAAPAPDPLFDATPTTAASMPDAAFDFDALFENDPADPTDPPVDTTTQNHTVNDFELDLGGGGGDDSQSLLRGLEDFANSGADNANTSNIEPTSNDFSMLDLPPVPVAGAPNSGTLDVLAGMGNLTSGAPQQESLPAQDQQVADDLMNLDVEATTFDDLFQWDDNQEGTQFEDQFMDFGD</sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="152" mass="15317" checksum="52DE0A5B8FC56BC5" modified="2020-06-17" version="1">MPPTTTTPTLTLAGAQTALAAAAAHATAIGVPMNIAIVDSATHLLAFHRMDGAKLTSISIAIDKAFTAAGHRAPTSVYKEAVWPGGAAFGIWNSNGGRFLTVGGGVPIVDAEGRVLGAIGCSTGTPAQDEEVAGKGKEAVEREVKRAGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIY0</accession>
    <name>A0A6A6RIY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RIY0"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34213" checksum="940409895DAD3777" modified="2020-06-17" version="1">MQTLSTITECDTRSTPTPEPHEKPFPFLHLPPELRLQVYEAAFQSNDPIGIVPSNGSWAVEPSYSMPSLSSRLPFALLLANKQIRAEAREIVYNVNTFALRRLVREDPKGWLCPANVASCFLRSVPFRALRSLEIHFGSVGSELAPLDGAEKQEWRGFCAALGGCTGLRALKLDMVGRLPGADCLSAGLAKPVSWIEELLEVFQKRKLQRLALRYVSECFVEDYEEEVWRVAGLLEVLRKGMLDGVEELGKKGLKEVREIVGDLAMDNMVMIECNDVCGMKMISLLEEDLTEWERCSKSYISIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q899</accession>
    <name>A0A6A6Q899_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_532121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q899"/>
    <dbReference type="OrthoDB" id="3690497at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="478" mass="54959" checksum="2F0F907E83DF240E" modified="2020-06-17" version="1" fragment="single">MELSLPRRKGPPRALPNEMLLEIFSHVGRGQSRLGTLRSIALASRSFNHLVTPILYSKFSDSEYASRRIELGRPLCFLLRTIVHSPHLAQHLKVFEWGLSGDRVQVFSDADFERVLAQARDQKLHLIAQFWPRLMILRDLDDKRPHSVDPLVAVLLNLLPNIEELKMTMYLPEDRIPAFMYPTPHGVLASKNLAKLRILQLCAEHDESDPVDLTPWLQLPSITSLRANSIPLDIRDQTLGPLNLTTINLHLVLIEKLILEYLLKSCKNLRSFSYEILALPRTLDDEEWASPDEALWSIRDLASDTLTELTFRLIDSNPDSDDYWNWDDLGDWDFSFRNMKNLKVLDIDAPFILGTDTYTGEEMTAPQLYSVLPPDITELRLHMCGQRVLEEIGNVARITRSVYPALERITIDSFKTFFWTPAYLKDAQRRFRKAGVAFDYTFDFDYYLGQAYDGDLGHAYGTSYLEEVIDALESEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9B9</accession>
    <name>A0A6A6Q9B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_519802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9B9"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="413" mass="45790" checksum="7E42E8AB9625E618" modified="2020-06-17" version="1">MSGPKPIASLLRLAIGRKQLSLSLRPPQRCSSICHSSRRALQTLSTSPRVPDFAFAFDIDGVLVRSSDPLPRAHKTLSYLQSQCIPFILLTNGGGKHESERVEELSNKLEVLLDTTMFVQSHTPFADMDEYKEKTVLVMGGDQDNCRRVAEKYGFQTVVTPGDILTAHPEIWPFSSQFLPVYAPFSRPLPQSINPTDPAQSLRIDAVFVYNDPRDWGLDITILKDLLLSRAGIFGTLSPKNNDPKLPNHGYQQDGQPPVFFSNPDLVWAAKYHLPRLGQGGFREAFEGVWAALTGGSRAGVEFQKTVIGKPFRQTYEFAEKRLVAHRKDLFGGQDAGALRKVYMVGDNPESDIRGGNSYESPLGTDWASILVRTGVHVEGQTPAWKPNKEVGDVWDAVKWAVEDSKWDGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAZ4</accession>
    <name>A0A6A6QAZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_567349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="377" mass="42290" checksum="85F0DED040EA939B" modified="2020-06-17" version="1">MYHGATDLCRMCWALPRHGNHHSHDDDARRVSATRLPSSRCGGDSAGRKQGFEQWAWGSVVEAVSRPFAGWKLGRRRCWTKEGRGAWQHRHVARPCLAAREGMNAWRAKPIVRRGAPHRRLVRAGWGGGWRWWRCDGRGRRTATGAERSCRCTHMKGPWAMAGKVSDRHGNCINHRGRLRRHRMGSLQPRWQLHFLQPGAEPPPWTPSSRLGGRQARTLAQHSVPVPDPPMESTLPLSPMWSRPLKRGEHPTASQMRSGTHQHTFKVARLPVRINPVPPAAALSETSALWMRPWARLCRPEPRLRGRGQTRVRRALPGSIVCCAAGVGKVASSTPQRMTMRCHLESQHRARVSSSLHSTAAVVTTTSSTALERKHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDJ1</accession>
    <name>A0A6A6QDJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_154756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDJ1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="187"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="312"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="547"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2490488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="76263" checksum="9053DA9263266B6B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDL1</accession>
    <name>A0A6A6QDL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_184534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDL1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001164">
        <property type="entry name" value="C2H2 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2489547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="515" mass="55971" checksum="1FDF80AA287BD6E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG54</accession>
    <name>A0A6A6QG54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_596032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG54"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="250" mass="26405" checksum="771E116CE6D552F6" modified="2020-06-17" version="1">MATTIVLITGANSGIGFATSKVLACASSTFHIIIASRSLEKAEAAKSTIEAASPKGSLSTVVFDVTDEESIEATAALVQQQFGRLDVLVNNAGSGSMDMDLKARFQLCLNTNVIGPALVAAAFRPLLLKSQNPYSIFVSSGERTLTRNAHEKPASHAGIKNGDAYQVSKAALNMLAILEARDYGPQGLKVFAMSPGFVRSNLRGTSEEARSGWGRAGDPEVSGELVLSIVEGKRDGDVGLFVHRDGVYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG89</accession>
    <name>A0A6A6QG89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_584707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG89"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="28707" checksum="B9D55543C9439D8E" modified="2020-06-17" version="1">MPSYVVVGASRGLGYAWLQNLSASPSNTVVGLVRTPGPVIDQLTSDKISNVHVLPADLADHVSLKAAAAEVSKLTNGSVDYLIVNGAYMNHTTANLTPTALIGKEELLQEEMRRNVDVNLTGPMFAINAFLPLVRKSSIKKIIVLSTGLADPVGTKEGGLASAVAYSSIKAALNMVVVKYALELKEEGIVVLALSPGVINTRLDTPSEEEMAGMMDMMKRFQLKYPHWTGPMKAEESVAMQKDVIEKITIEESGEFLSHKGNKEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG94</accession>
    <name>A0A6A6QG94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1977-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_595786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QG94"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="39662" checksum="7B8D90E5D87446E6" modified="2020-06-17" version="1">MSARASGADSGDAKHRAHHDGSSGRAFTVEQKTAVIRIKRCSPTAFYEILGLEEVKLTVSEGEIKKAYRKLSLLTHPDKNGYDGADEAFKLVSRAFQVLSDPDKKSKYDKFGGDPDNRFAGASNAGASPFSNFSRSQSGGASRQGPMWEEEISPEEMFRQFFGGGFGGGGGGFGGPFGRTSCPGFVFNLNGGPGIRVHQFGGGRPRRRPATAQPPGSEPAPTVSSALSALLPLLVLFIIPLLSSLFSGGPAPQGPSVRFEGANPPQTYERTSYRMKVPYWVNPEEVSDYSAKKWKELDKTVEIKFVHQLNILCEREKDTRDRLVQDAQGWFFPDEEKLAKARKYDMKSCRRLRELGYNPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHL3</accession>
    <name>A0A6A6QHL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_565401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHL3"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="235"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2491702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="655" mass="73661" checksum="807530B713D0C0F4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHP1</accession>
    <name>A0A6A6QHP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_565257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHP1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="516" mass="57756" checksum="0D368B5BF87FC625" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI18</accession>
    <name>A0A6A6QI18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_530284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI18"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
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        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="173" mass="18771" checksum="620F1929E32F1B66" modified="2020-06-17" version="1">MSSHRLFRFPKPQWLNNANARTFGVYTAGALFSLGFYILIDAAAYSKSALNGSDPAVHITFVDWIPGICSALGMLVINSIDKSRLSADSFSYSGNGVAWKARLVLFLGFALMAGGLAGAVTVLVLKYVVPEYVWPTLWMGTANVVANGCVMLSSVVLWVAQNMEDEYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI48</accession>
    <name>A0A6A6QI48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_144424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5391053at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="471" mass="53326" checksum="AF75E5C3DD7EB99A" modified="2020-06-17" version="1">MNLTKKPNLGMLDFSYLWQNSVDGLKTLWTRKPTFEVEDRSSQTTSATTSSADEPMQDVSIAGNDIEEGPSTPPDVDWVFAGETEDDYTAGPAKMVEASDGTKACAAVALSFDLSKKIQDSLMGRRMLQQLSFEIEQQRDEIAAEEQKLTIFILRQDRKVETIEIEVEEAGGEPTAQQQDKMQEHRAAIRETEKQRAMLKENDELLVQRWEGARQQQEMLQNEVNVILEDVFVTCNLLPPVMYNEPSLEQHEGFYDEEEQPSFDDANVFEAPTLGNTTVAGQNVLRVGDNAQNAAIQAGTNLEHSRGDLLRAQRNFDAYQCGYNQDLQAYLSSQVNRPYDDVKLEHDLLHLQKGRRLTGELIQAEKRFEDAEIEAKAAGVFPGYYQESNFADCPDDGYREGQELEIAARVDRKRIEEWLENAEGDGMSPPPEPEMDQWSVDSDKPFDSISVLAEGPNRKQIDRWRQETGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIE2</accession>
    <name>A0A6A6QIE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_585037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="255" mass="28294" checksum="D86F659DF610857A" modified="2020-06-17" version="1">MFRNNYDNDSVTFSPQGRIFQVEYASEAVKQGSVVVGIVSKTHAVLAAIKRNAEELSSYQKKIIPIDSHYGVALAGLASDARVLSNFMKQQSLASRLTYDRAIPLAEITLRIADRAQTNTQQYGKRPYGVGLLIAGVDARGPHLFEFQPSGVTQEMQACGIGARSQMARTYLERNLEEFEGAGREELVKHALRALKDSLAQDKELTIENTSVGVCGIDENFKLYEHAEVQEWLETTFENREAPAEEEGMEVDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIG0</accession>
    <name>A0A6A6QIG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_596023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIG0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="293" mass="31207" checksum="9CD5BC445DC8AE8C" modified="2020-06-17" version="1">MAPAPYPSPTPTWHTTTYPSISPTRPELSAKGKSVLVTGGGTGIGAATALHFAEAGASRIALLGRREQPLLDTKAAIEHKFAGVEVFIASTDVTKKSEVDAAFAKFAGDQKIDVLLSNAAMTGPHDVVTADADGVGMLDAVHQNLSGSLFVAQAFLRHAAKDSVAIDVNSAAAHLNFIPSMASYHIAKIAVYRLWDFLAYTNPDVSVFHIQPGVVDTDMNRKAGGVATVGHSDDVSLPASFNVWLASPEARFLKNKFLWVNWDVDELKAQAKEIEASARLSIQVVGWPFENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIJ2</accession>
    <name>A0A6A6QIJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_515852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIJ2"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="171"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2491473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="403" mass="45144" checksum="6FFB158F1DA2473C" modified="2020-06-17" version="1">MSPPVAPKKENAIRFGLFGASWIAPNAIIGPSRSHPEVIVAAIASRDKSKAQAYAKKHGIPIVHDSYEALLADSTITAVYIPLPNGLHYEWAVKSLKAGKHVLLEKPSTSNAIEAASLFNLPLLSSPDPPVLLEAFHYRFHPAWQTFLSLFDGSDIASATVSQYLFAGFFPLDDIRFNYSLAGGTLMDFGTYALSTLRQVFRAEPVSVISAEPRKAAADDRIDEAMRATYEFPGGAKGSIEVDLQARGGLPLPWLTAYWPGYFKGLPTITVKLKEQDISDSEGPSHVVQRAFVFTNYMMPTHWHRIEIIEQHTLHPPRGEKLIKKWTEKKTVKVYRWLEEGQVGEEWWSTYRYQLEEFVNRVKKREGSGVWIDSKDSIKQLEMIDATYLKAGLPLRPTSTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ39</accession>
    <name>A0A6A6QJ39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_468451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ39"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="58"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2491683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="334" mass="35935" checksum="35B0C7DE1FF970EC" modified="2020-06-17" version="1">MAETMEDTVMTSADIEAETPPDAVFIAPSIHKPDVLAGRSYAHYSPIPSLISADMSTECVLGVDEAGRGPVLGPMVYGLLYLPLPLHTSLLATAHHFDDSKVLTPAVRSSLMRTLCTASTDLHASCGWATKVMSARDIAAGMLQPTSAYNLNAQAMDATIELIKNVLAQGVNVTQIYIDTIGSPVVYQRKLERIFPTVQITVAKKADSLYPCVSAASVCAKVTRDAALEVCAEAVVGAGGEGGWGSGYPSDARCSGWLKRSMDPVFGWGSETRFSWGTAKELLEAKGAPLKVEWPVEGEVDEMKMTDFFVGRDEETEGDELSGWYGRRVTEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJW3</accession>
    <name>A0A6A6QJW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJW3"/>
    <dbReference type="OrthoDB" id="10658299at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="28372" checksum="E6658EE3E48A8B84" modified="2020-06-17" version="1">MTPRRSARLAARRAPSQSQSLSQSSSPSPSPSPSRSPIYTRTRSRLTAKITKLTTTSNPTISSTSIANPLHRTRIPRVRILDDEASEGSASSTASTPRSFHAPDLSGSDREDHLHGRSLNSDSEDSRFGSDEENEDYFDESGFVVPDESDEWDEFEESSEDEGAVGESGYDGDASNGSTESESGSGSGSGSEGSDELMSDEGSDEDESEEEESLVASPLSSDSEEEEQRLPVVASRGFARRRQVRSASSSPVPSRGSVPAPAISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKM1</accession>
    <name>A0A6A6QKM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_466329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2309723at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell wall organization protein/glutathione transferase (Gto3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
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    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="159"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="336" mass="37991" checksum="00F1D4E63AB6B4EA" modified="2020-06-17" version="1">MTTEIHKAGTADGWHGAISPGGEFPPEAGRYHLYIGLFCPFAHRANLIRYIKGLTSIISLSVVLPYPKGDDKGWPGWKFPASDSEYEGATVDHLFGSQYLHEVYFKADREYKGRYSVPVLWDKKTGSIVCNESAEMLRWLPTAFNSLIPEEKASIDLYPPPLRSQIDQISEWMQKDLNSGVYKAGFATTQEGYDAGVVPVFAALNKLEELIASNGGPFILGNRMTELDVRAYATVIRFDVVYVQHFKCNLGMVRWDYPVISNWLKKMYWGVEGCKESTDFRHIKENYTKSHAGINPHAITPMGPYPNIEEGFEEYLTKLRVGKINLPAVLEYQSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLA5</accession>
    <name>A0A6A6QLA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_71799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLA5"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="100"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="339" mass="36619" checksum="51B698422AF1EF48" modified="2020-06-17" version="1">MSSPSDLTLEQSKFKESNIPVETTKINSMLEAIGRKGPHWHEVGPEKYQQMREAGESPLPPPIYLPEAQEATIPSRDPGRTIPLRVYKPDDGRPSRGIFLHFHGGGFVLGNHQCQDLTLKLYANSCHLTAISAGYRHAPSVPYPGPIHDCIDAAEYLVDHAIADYGVPLLFMGGESAGGCAAVLSAFHLIRSRPAHKLAGLVLPFGWFDMSLSLPSIATSTTVPPRVINLAEMEKFRDAYLPGMGEGEMRGAKVSPLFADFSIGELPPALLLVGSEDPLVDDTLLMGVKWMAAGAEAVVRVWPGCPHGFTVFPGFKPAAEAAEMVVGFLKEKLETLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMI3</accession>
    <name>A0A6A6QMI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TFP11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_464824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMI3"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2493200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="703" mass="78627" checksum="2B9957B3CD9DFAE5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNC3</accession>
    <name>A0A6A6QNC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_58449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNC3"/>
    <dbReference type="OrthoDB" id="20052at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2493875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="326" mass="36480" checksum="90F64EB6828E5AF3" modified="2020-06-17" version="1">MYAATSREDPINLQSLLTHCDARVTPSPMCTAAARGFRNAAQHLLRNGALVDGIPSPYCVGIPIFRALQYNNEEVFQLLINSGADLSVRSSGTNVSTVLEVAALYRSSSKLIKKLLQEDGSYINMVSSKGLTIHYWAKHDSFIGRALQRDEIAPSLEAVRTYDVDHCDKRVLYSTILHILKSMRGCCTVRHHYGRAALSSSLIICGRSYYEYAAIFDEQGIALNNIVVQPYRCSNCSVSLDGFMRGTRYRCLNCIDTDLCADCYSSWQQSNGDMEFCKSHEFYETPRPCWYGLKEGTVTEDGKTLAELVSFLEDTFTMLLASEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNK1</accession>
    <name>A0A6A6QNK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_464330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNK1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="505" mass="56495" checksum="49F92B258DED5D23" modified="2020-06-17" version="1">MIIEAPSSLGDTENESKEGRVTILPNTKTTKDGILLVPQPTDDPEEPLVGVFQNWSFWKKHLALIALGFETFLVKFTATMLAPGAHGLALQFHTSARRASYIASAASVVPSVAPFLWIPLSQRIGRRPVLLGGNFIAIMFTIGLARSETYAQALTLRIFAMFFASVGICITPAAISDMFFLHEKGKRMGYNTFLLVCAPYLGGVVGGSIQYNENLGWRWAMYIAALLYVALLFAQVFLVPETIYIKKQANAESEEIKRSIWRRLGFRKPHNEEPMRVTWTRNFRMFAFPAVVLPSFWFSICFMTEVANTAGFPLQFGIGTHYNFNTQQIGFCSFSGFIGAVLGEFVAGPICDFVAKRHLKKGEKWVPEMLLKVAWTGVVFIPAGVLLYGLELNYPTSWAAALTGIAIFAFGQEVLITVLLTYMTDCYPLEAAECAVVFQFFLNLNSYHPPFYVPQWILQPGGAKVPYIVFAVLPILFFPFGVGIFMWRGPQIRAKGRIFAPRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNM8</accession>
    <name>A0A6A6QNM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_61606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2494001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNM8"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="469" mass="52414" checksum="AAA872E07DBA488A" modified="2020-06-17" version="1">MGSKFMDYLRGTQNKPGERALVQKLDFFILTFCCLMYFLNYLDRSNLANAYLSGMKEDLNFKGNQFNQINTVFTVGYTIGQVPCNVALYYIKPRIFFPSMMVIWAGLTMCTAAVHNPQGIMAIRFFQAIAESSTFVGTHYILGSWYTEKELGKRSGIFTASGLAGTMIGGFIQTGINSSMDGLSGLAGWRWLFIIDGIITLPVALYGFFFFPDTPSTTTAPYFSADEKALALSRVPEVDERTPISLSFLKRCFRSWYWYGFVMLWIIAGETESFSSNSLLGLYMKANPTHKYTRAQLNDYPTGVPAVGIISTLFWATLTDFWGGKRYLVGYWIGITGVVTSAMILAPGASTAVHFGAYYWAGSVYACQATFFAWANDVLRYEEDSLRAVVIASMNMGSNAVNAWWSIIFYSADQAPQFTRGMWAMIATSIALAVWTTGMLYMTVREEKKRVLTRAESIPGKSEVVEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QP73</accession>
    <name>A0A6A6QP73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_563129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QP73"/>
    <dbReference type="OrthoDB" id="3760002at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="344" mass="35776" checksum="4F34F85E6FF86F78" modified="2020-06-17" version="1">MAIVNPGAGLAARLFWQLLNLHSRTPVAAKAGSFPAGSPSGLVTGTDAILMSTAVLVASNLVKPVSLWPQPVPPGCHVDAGLARDPFAAPGRGLSANLLVVCSALHSTAITSRLDAALKPTQHGNASTAPARGRGRLHAEGHHVPMWTGESGPVISGARRCLYKAAHCALPLSIVDSSSTSHAPHTQLPAASAPPLSSSSYSSPQGSPLLSRRLVLVRPAASATAQAPAPDPDHSRPIPTSPTKLARPGLARSPPIVVVVVRATLFSSLQATGLQLSSTQLALPPYLDPRNRQAATMCQKFVHTYSCGHQMVQKAECATSRSTNCGVLQVKNIKHDEKCDSCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPA0</accession>
    <name>A0A6A6QPA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_551352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="50"/>
        </location>
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            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2493533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="218" mass="24375" checksum="647650ABB92B149C" modified="2020-06-17" version="1">MKIGEFCNAIGVSNKSYNGFMSQSGTYKGSGFAAYEAAWEFFKKRELKGIPAPKKKRTTAPATTVAAAAASNNVASVSIPGEETDAVDIYDTCDEIRRKINLHLKKDGVTQAGFLRDLMAQYHKSDRKIQSKQLTDFRSKKGADRGNTSCVYYASYVFFEKLRIKEGKKKTPTREKMEQIWGAQGGMNTTDRGTGYTWSGPGMVPREDRFGRVWNDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQH3</accession>
    <name>A0A6A6QQH3_9PEZI</name>
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            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_539701</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="688" mass="77669" checksum="93AFA9B834237F62" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQP5</accession>
    <name>A0A6A6QQP5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">BU16DRAFT_589378</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
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            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
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            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="436" mass="47971" checksum="553A0237CDA201C8" modified="2020-06-17" version="1">MSTSEYIPVFNRSETILSTTLVFLVLAWIAVSLRLFVRLRTPISLGWDDLFVCLAIVCILNHSEEHCSLCQSSCTAGSVIVCLQPGASMGKHMKTLPIHKLEEYFSYVYAANVTYCSSTTLIKIAILQQYLRLFEGASKLVRRVCYVLIALTSAWGISFSLVALLGCHPIRANWEALYFSDLKLNAKHCIAFGSKDPGTIFRTFAGHAASNMFLDILVLLTPVPFLKTLKMQGKTRWGIIALFAIGAIVTLFSIGRLASLANSRAGTFPVFDVTWYAPPIFIFSSLEVEVAILCASIPIFWPLVASLAFGKILVVNEISVHSAPRDSILLELGSRRRRGSVHSAGDGDVKAGGFLSARGRRLSDESEGKGELLKRTESEGQGEQERYYADRYVAGLVAPDWGNREGAGKKKKKKGAFTTTVERAKTPYDHINALQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRB1</accession>
    <name>A0A6A6QRB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BU16DRAFT_78726</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5979581at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="126"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2493387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="479" mass="51918" checksum="A931CA4DF268D8FD" modified="2020-06-17" version="1">MTSGNAENVPPLTLPPSSHQPLELQLPQPSQSPYWEQPPLLPPPPLPRSQSPEGEQPPLTPPPPLPPSQSAQCSYLPHLIPPPPPRSSRIPRGVRIPNLDYVEDVSKYRRGGLHPVNLGGVLGHKYKVIHKLGYGGFATVWLARVLGEQGYVAVKIPRADSSNKEITILTHLQSVANHLAIANLLDTFTIAGPNGIHNCLVSEAGGPKLGAICRFGKRLPISFVRPAAQQLAACVACLHSAGICHGDLTDNNVLFEIKDLQQWSEAELYQHLGAPKAATLLQFNGDPAPPSAPVEAVSAINYSNFDTGLFSGRTRIVDFGEAFSTSSPPAGLGTAASYFAPEMLFGYPPSLASDVWALGCLIFEMHTSRVFAPAFFGSVEEALGMTHAALGALPEAWQDSWCDKAKPLTSGPGKKHYWFDDQIQRSRPLDSEVRKAMPELSLEELDLLLDLLKGTLAYEPSHRLTAAKVARHAWFTREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRJ5</accession>
    <name>A0A6A6QRJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_511379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRJ5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="543" mass="61076" checksum="E58E48F9591148FB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRK0</accession>
    <name>A0A6A6QRK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_463121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRK0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="509" mass="55953" checksum="67CF769AF9EAA12D" modified="2020-06-17" version="1">MDSVSFDNTKTHHQAALVWAIVGISWGAITYSYAGSIIGTTLGQPSFIMYMGLATNKHAESLIGTMTGLFYAGGVFGCLLNAWMADRFGRKITVCTGAVINIISTACLAGSVNIGMFIAFRFFCGVGSYMLYLSVPLWVIELCPPKGRSILGGIVGLFGVIGYILAAYVGIGFFYYKTTTSSQWRAPLAIGCFPAIVLLCWMPFLPESPRWLLAVDRNDEAWQIVKKLHTTKDDPDHEFATAEFYQMKSQHDLDRGLDGSWIEMFRRPSYRRRALLAFFLPVIMYTTGNLVITTYAASIFASIGYGPGDSLQLLAGIYLAAIAGNLISLTYVDRVPRNVMLCTGVIVVTCILSIETALVAKFLGTGNKAGLSAAAAFLFLFLAAFNMFLEGISWYYPAEIFPTHLRAKGMTLAVIGFCMVDILWLELAPTAIADIGWKYYLVFICLSVFGAATVFFLYPDTLGKPLEEVAKMFGDDDLVAIYQQDIHIDHAKHEVIEKNGTTFKEEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSM8</accession>
    <name>A0A6A6QSM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_461967</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSM8"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2495405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="356" mass="40429" checksum="315755C5146F9532" modified="2020-06-17" version="1">MLSTRTATRTSLASKQTGARVLKTLTSSTSIGLQPSFIVVHQYGLANSHRNFSTTPQHRIKEFFPEAEAPSVRKTPAAWPHPIYTPDQMAAIPIAHREATTFSDKCALGLARFARWGLDTVSGYKHDKAVALAKKDAAAAQTKYGMTEEKYMIRNIFLESIAGVPGMVAGMLRHLHSMRRMKRDNGWIETLLEESYNERMHLLTFLKMAEPGPFMRLMVLGAQGVFFNAFFVAYLISPRAAHRFVGYIEEEAVITYTREIADLEAGRLPLWEKTIAPDIAVEYWKMPEGHRTMRDLLYYIRADEAKHREVNHTLGNLDQKNDPNPYASVYKDESKPHPTKGMEHHQPTGWERNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT16</accession>
    <name>A0A6A6QT16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_550251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QT16"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2495555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="357" mass="38658" checksum="EBD0CD55D51F4357" modified="2020-06-17" version="1">MGSLHPTKKTMKAQQYDARDNKLHLNEIPIPTPRAHELLVKVACASLCHSDVMLFEPNDQGLILSSDPCVTIGHEGSGFVVSSGSGVADLGFREGDKVGFLCAVDCCFECHACRNVHNSWCVTGKTKMQGFTLNGYFQEYVCVDARAAMVLPEGLDVYKAAPLFCAGVTAFHGVEDCGLEEGKWMAVIGCGGLGHLGIKYAKAMGLKVIGLDIAPQALDAAKESGADHVFNTLEDKDWQKKVIELTDGGVDAAVNFTASKKSYDDAPAIIRPGSGILMVVGIPQKPIELNALDIALGRYRVRGSNNGTCYNMRPCIEFSAKHNINAHLTHYKLEEVPKMIELMNSHKAQGRMGVRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QT87</accession>
    <name>A0A6A6QT87_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_394462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43791" checksum="6C6FA459F972B5A1" modified="2020-06-17" version="1">MASSCTRYNHLTGRPIRRGAGQKRKDDGYVDSVIIEDDIIPVESCSEDEDGNPTVRKVSKRKRTPSPTPPPLDALIDDDLPPCEESDDEDQDTDTAQPIELTFHIPPGFKGPLVVRLDHKLLATAGADSSSTKHSIDHGSRLWFAKRHRKTSKTMTKRPAKVAAGTHRPSATGFLKLPPELRNKIYKLLFVSQSELRFNNPQFSLSSAFLRTCKQVHDEGRSILYGEGTFVFERNRLSRSPFWDPVAKEIGYKDMRRFLTMIGDNLALLRQVRVVFEDATPSSLPYVRSQEERRFIHDEHLIECLRILRRAELKKFTLCFHGRKTLTEYDGASFLGRVCEIQADKVDIISNPRCWYMESKIHYTVKEPLVKSMTRDTPLYTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTI7</accession>
    <name>A0A6A6QTI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_391067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTI7"/>
    <dbReference type="OrthoDB" id="3858188at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="269" mass="30271" checksum="472C0EAA8C85A00B" modified="2020-06-17" version="1">MTPGLGQSKWALEQPKRRTPAQQLNEDKDKSYRLLRRLYWKAEGLLCSWNRALDAIKLRSNEHHDHPHSTLIDFALVEDGAMVQSMFKVDFFEFYVLLERYIVLCLAILGVRVSRKDLTAAKGPYHSGATPTFGMHQFHANLLATLDELECPLHAALGQQDVRIYLGRAKDYRNRWKDADELDGGPDATDSQGGRITLEDLKLGTMLKTILAGLEQASLVVKDRQPGHTGMLVLNGEGTGLQEVEYEAMDMDDAPWEAVGDAMDAMDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTQ1</accession>
    <name>A0A6A6QTQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_527310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophium</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Patatin"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="28"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="317"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2495494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="697" mass="76712" checksum="D9666C8652B789DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU56</accession>
    <name>A0A6A6QU56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein UsgS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_397753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU56"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38184" checksum="A4BA94D6FAB0EC22" modified="2020-06-17" version="1">MSNFDPNAILRGAQLTLVGAHRALQNPGLFTSDHYRQAAIAVAGGIAIRMIIAIPVIGVRILLWTLSFFINMDAVSWDNYVVDGLYFLEHSVLQVPFFLMSMMRYVTPTLDRMFMDSLQWVDQTYTQKHKSENPQSLRAIYGRRAGISLAIYALSFLPYVGRFVLPAASFYTFNNAVGLTPALVIFGSSVFLPKRYIVMFLQSYFSSRSLMRELLEPYFSRVRYTKEQKKQWFRDREGVLFGFGVGFFIFVKIPLVGVLIYGIAEASTAYLITKITEPPPPASQAEQFKERDVRWKNKHEFLNLPLSMLDAHNVAISEKEHFPAQKAMPRQEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUF9</accession>
    <name>A0A6A6QUF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_526372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUF9"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="196"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2495826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="451" mass="49071" checksum="2EEE54A956AC5BFF" modified="2020-06-17" version="1">MTAPAHKSKVADISLAAFGRREIELAENEMPGLMATRAKYAEDQPLKGARIAGCLHMTIQTAVLIETLKFLGAELTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYEWCLEQQLTAFKDGGKLNLILDDGGDLTALVHKKYPEMLKDCFGVSEETTTGVHHLYRMLKNKEHGLLVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCAQALHSMGARVIVTEIDPINALQAAVSGYQVTTMEDAASQGQIFVTTTGCRDILTGAHFEAMPNDAIVCNIGHFDIEIDVAWLKANAKSVQNIKPQVDRYLMKNGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQILLFKASDEAFSKKYVEFGSTGKLDVGVYVLPKILDEQVALLHLDHVNVKLSKLSEVQAEYLGLPVNGPYKSDIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUT0</accession>
    <name>A0A6A6QUT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_45497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="128"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="764"/>
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        </location>
    </feature>
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        <location>
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            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2494687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="822" mass="90440" checksum="63FE69875477EFF1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUU9</accession>
    <name>A0A6A6QUU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2495894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025586156" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="102" mass="10795" checksum="5E0FE0B873123860" modified="2020-06-17" version="1">MHVPTLTSALLALLATTASATKIISYSGTSCKSGDQVTWTGHSVNCEKLANVRSFEVFNVDSGCSVTYYSDSECSNDATRATAGSCFGYSSGGKVRSWSWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV54</accession>
    <name>A0A6A6QV54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_432949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
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    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="19"/>
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        </location>
    </feature>
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            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2496004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18215" checksum="0F35BE1E3F17351C" modified="2020-06-17" version="1" fragment="single">MRTSLFLSVLSTAALGLATDAPETTNNLSASYFAVLPNRVDTEVRGTITIMSPPNGKGADIAITLSGLPSEGGPFLYHIHDKAVPADGNCTGAGAHLDPYGRGETPPCDSSQKQTCQVGDLSGKYGTINATGYSAAYTDHYLSLVPGTPAYFGNRSIVVHFANKTRITCANFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVD9</accession>
    <name>A0A6A6QVD9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_431107</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVD9"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2496401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="159" mass="18269" checksum="62F68DC46A09C218" modified="2020-06-17" version="1" fragment="single">SRFVPGGTVDEPIERDDEWAKAQQELEEERRKREEAKEQAGGKSLFEILEANKAAKQEAFEEANRFKNQFRALDDEEVEFLDAVLDSERAKEAAIRKETREQLDSFRKQQEEAEKAALVEDDIAVPEEEQLFAVGRKRKKGKEKESLRGVKLRKSSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVU4</accession>
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        <name evidence="3" type="ORF">BU16DRAFT_458300</name>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6QXM3_9PEZI</name>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="12">Aspartyl aminopeptidase</fullName>
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                <person name="Bills G."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYI3"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2497134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="62245" checksum="34F1A422B050D875" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYK3</accession>
    <name>A0A6A6QYK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_458595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYK3"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="36"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="275" mass="29976" checksum="D12D636B6BA176C2" modified="2020-06-17" version="1">MTHRAPVISISHGGGPMPILGDPGHAAIVKSLTTKVPELLKIGTPEQPRAIVLVTAHWSERVPTISSGKKHSLYYDYSGFPAESYKLKYDAPGSPEVAEEVRAALQKVGLEGELDAQRGWDHGVFIPLLLIHPAATIPIVQLSVLASESPAQHYRMGQALASLRDSNVAIIGSGFASFHNLRLMFSGALNDKSFKTRNAAWSKAVENAVLEKDDGEREKALEGWRSWPGAFEMHPRGGAEHFMPLVVCAGAGGEGKGERWVDEFMGLDMYSFYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYN4</accession>
    <name>A0A6A6QYN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_312031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYN4"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="35419" checksum="F7BDB8554E1F1A5D" modified="2020-06-17" version="1">MSANEPQAMPGWYWPDDLPKAEYEPSSGTQSSTPQSNSQPQNERPRRRFWPPRQCRICLETVQPTYHTAPEHLPGIFQSGPSVTYESEEGRLLRPCKCKGSSKYVHEGCLQAWRHSDPSYGRRNYWQCPTCGFRYRLARLGWGRSLASKTAQISLTVGILILAVFFLGFVADPIINLYLDPYSYFSPFSSSQPEYYYEPEEKSSWVEHFLKGFTSMGVLGFLKVLLSNPFSYFRLGGGGTRGRATGRDRYEQVSWIVILVGVSTFLFAVYKGVRAWSRRTLEKAGEQVMDVQPDDDDDEDDQVPPAETETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZI3</accession>
    <name>A0A6A6QZI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_421716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZI3"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="124" mass="13673" checksum="9A24543AA690708E" modified="2020-06-17" version="1" fragment="single">GDTALHLAAYRGLEPTMKLLLQRTETKVNIRNNRGGTPLLGTAKYGYELSARLLLKRDDVDINLQDRDGNTALHHAAKRGYELVTKLLLQREDVDINLQDGDGNTALHHAATEGHAPVTNVLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZV2</accession>
    <name>A0A6A6QZV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_457317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZV2"/>
    <dbReference type="OrthoDB" id="3937045at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="119" mass="13962" checksum="C7679800B6138F0A" modified="2020-06-17" version="1">MQDVKVSAKAGEAREATGFDLIQWRRFLLISRLEADRYVQHRPQYQSWISLPASEQNALWTAINLRLDAENIPRINQSVLIWRMSQAMREARRLFCRFSLRCSCVWCGLMWWTGLTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R028</accession>
    <name>A0A6A6R028_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_525622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R028"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2498055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="264" mass="28179" checksum="7E9340862E135701" modified="2020-06-17" version="1">MAHSHSHDGSHSHSHSHNPTPADHGHTHEILDGPGSFLGREMPLIEGRTWSDRAFTVGIGGPVGSGKTALMLALCLALRNTYSIAAVTNDIFTREDAEFLTRASALPAPRIRAIETGGCPHAAVREDISTNLAALEDLHKDFDADILLIESGGDNLAANYSRELADFIIYVIDVSGGDKIPRKGGPGITQSDLLVVNKTDLAEIVGADLGVMERDARKMREGGPTIFAQVKNGVAVDHIVNLLLSAWKASGATQAHKKEYQPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R042</accession>
    <name>A0A6A6R042_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_334615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Ctf18 RFC-like complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:DNA replication factor C complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Elg1 RFC-like complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 3"/>
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    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2498118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="353" mass="39965" checksum="E25C766256D4C081" modified="2020-06-17" version="1">MALLVDKHRPRTLEALTYHPDLSARLKSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELYGPGVEKIKIDARVFQTTSNRKLEFNIVSSVYHLEITPSDVGNYDRVVVQDLLKEVAQTQQVDLGAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRTLLVRVAAPSEGEICEVLKTVGRKEGYKEVETLNERIAKESGRNLRRALLMFEAVHAQNEAITDKTPIPPPDWEALIAQIADDIIQERSPARLLQVRAKLYDLLTHCIPATTILKTLTWKLLPKTDDDLKPDVIKWAAFYEHRIRMGSKVIFHLEAFVAKYMRLYESHLMGVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R071</accession>
    <name>A0A6A6R071_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_457832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R071"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="604" mass="64111" checksum="FF9934C77F0A6D41" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0H6</accession>
    <name>A0A6A6R0H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BU16DRAFT_312213</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0H6"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="85"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="86"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2497353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="332" mass="36421" checksum="5359F455EF91912F" modified="2020-06-17" version="1">MSKATLAMGAAAGAAATAAIYSLFNNSHPEPPITTTTTTTVSTPSRTGPPAPSPITPVAIRSPPLVDPNGLFQYGFPGPVADLNPTASLTSAFDRRTRNPFWVAEHITPLSLSTHNGDRKHSVFVEDASIPEMFRAKLKDYFRSGYDRGHQVPAADAKWSQEAMDSTFLLSNMCPQVGDGFNRDYWAHFEDFCRRLTGRYPSVRIVTGPLYLPKREADGKWRVSYEVIGNPPNVAVPTHFYKVIFAEDGSVGGQVALGAFVLPNAVIANDKPLQDFEVPLEAVERASGLEFATKLPAMRRKKLCQEVNCSIFVKDYKQRQKTFAAQNQGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R199</accession>
    <name>A0A6A6R199_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_536216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12573" checksum="FE73E96922EE80CD" modified="2020-06-17" version="1">MTASDLPLYCSSKHGVLGLMRSMSIPLAKENIRVSCILPGAIHTSLHPEDVWAQFGRENFTSIDLIVKTVLELLNGEEAAGKAMEVSAGEVFDRKQPKFCNETMRLIMTDKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1C4</accession>
    <name>A0A6A6R1C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_559368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1C4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="305" mass="34013" checksum="0626BC0ACDFFC9BC" modified="2020-06-17" version="1">MLHDSNKPIPPDIFGNDVTNLNEFARRAADLLEVEKAKKKVQADADDLVMLRSKTQENAAELVSLKKKAEEDSEALKSAKKKAEESSDELGKAKKKAQDDASELVKLRTQVESWNADCPENNLHPSFNGALILIVNPQASHIVDVGIENHARAHAWPIEWNGRFFNSNQMLRLEKVDSANRKSAWYITCRGGAGERDTWGDCLTAADPSEKQNPNVMNRKKDPNGAGKRQHWFISFENWGYYRFFNVGLGEYLILSQAPPQAPKVASVSVGSALTGIGLRTVPADNGGNKMPPELARWAIYRWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R228</accession>
    <name>A0A6A6R228_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_456897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
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        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    <sequence length="2326" mass="253440" checksum="AF6C03B2E5255B5E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2K5</accession>
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            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Mytilinidiales</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="match status" value="1"/>
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            <begin position="62"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2498140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="907" mass="101194" checksum="9B2B276DB2DF4338" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3B4</accession>
    <name>A0A6A6R3B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_615326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3B4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="160" mass="16858" checksum="9A3F409D3D9B9C16" modified="2020-06-17" version="1">MDAECLTAMASKLAVHRHRAERFTMHEKSPLAPPCVLDLFDIAASSEASIGAGPGGLPRPVHAVQQAPPYAVRAATGHGSRSSTSPEEPRDAQTASPARTASPTRLQRPAPSSPRREAFTADRTECVDECLRQRSGGDGWGNLSLEHANPAKALQMGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4B5</accession>
    <name>A0A6A6R4B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_524057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4B5"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="425" mass="46728" checksum="CFC0C0F6D215BA42" modified="2020-06-17" version="1">MPRRSAKQVKASASRSSSKRPASPKATPIRQSKRAKATPAKSSYFEHDSEDDVDDAVSEFAEDADGGKESVYDEDEAKTSPSPSAESDIEAEDSNDEDETPRKKGQKAQPKKGVSMPIRGGTKDKDLWKTGAKLPPGSQVIIKKPKARDAGDTPYTDESIHPNTMLFLKDLAANNDRAWLKMHDPDYRASLQDFTTFLDCLTQKVIEVDETIPELPVKDIIFRIYRDIRFSSDPTPYKTHFSAAWSRTGRKGPYAAYYVQIKPGGNFVGGGLWCPAAEPLGLLRRDIDRKPHNIKRVLTDAGIRRAFLGGVADSEKKAVTAFCSQSENASNALKTKPKGYENDHKDIQLLRLRNFTIGTKLADDEVVGPKGLDRIVELLSRLAPFITYLNSVVMPDAAADSSSDEDSSEAEGEDEGEDEGGEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4D8</accession>
    <name>A0A6A6R4D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_454191</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4D8"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="78" mass="8786" checksum="7A60A065EADDA1D4" modified="2020-06-17" version="1" fragment="single">TAVLVLATLPQIEPMAAEISVLVMCHTRDLACQIKNEYARFSKYMPEVKTIAVYGSAPMQKDIDMHANKHQHPHIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R607</accession>
    <name>A0A6A6R607_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="84" mass="8231" checksum="D636FF8D1FB63A95" modified="2020-06-17" version="1" fragment="single">TGFHVASGVVSLAPGIVTAPVLGALGWTAMGPQAGMYPHSPENFTASTPARGIFATLQSAAMGGYGASVLAGGTRLVVVAATFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6E1</accession>
    <name>A0A6A6R6E1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_557624</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0071819">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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            <end position="95"/>
        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="408" mass="43790" checksum="365FBD93D111527D" modified="2020-06-17" version="1">MFEDGPAELEDLLKSGVQISPATLDEVTKHIFEDVLYDVMSSIALSCHRSEKLLRMSSAATQVESLAVAQLDSQPSAKTAHAPPLPPPISNDAASWDGQRVHLKGNPLKTTTEIICPHCKLPRLKYPASGKGAQAPDLTKEYCNLHPWVQRPGHDVYGNLFPTDMAKSKKERELQKQQLKNADKESVGTPGSQDTDMTGEPKLNTGGKPAHYIPWHTCPNCKRSLLITRFAQHLEKCLGINGRQSSRNAMAKLTGQNGNGSGMGNTPLGSRMGTPVPASQGSGAGAKDKRISPVKRGGDDDDGDDNETPEKKKKKKSSYVKKADRGGKDGTLKVKLKTSKESQEKEAAIAAKRLPRPAESGSGVSKAGGEGKRDRDGDADESPRKKLKLTLSKEDSSLSEIGSNGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R725</accession>
    <name>A0A6A6R725_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_535668</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2499297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22442" checksum="020B50457717DB9E" modified="2020-06-17" version="1">MHAGSRNQPTSYLKLAFYGIRFCQLLASVIVAAEMFYFVWQIEHGGHRVPWMFFFLSAVFNGAINLVASALWIAGFGLLADAMNETILDACTHALWGNSTGINICRLYKLLFAASLFGVLSTISAFTLDVVVYMRVRPGAKHSKAQPLLENAGDTLYQAGYDGPYDPHNVKTKSPMDRTSASASRLPVFDTYTHGRKRSQHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7G2</accession>
    <name>A0A6A6R7G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-serine dehydratase-like domain-containing protein</fullName>
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    <organism evidence="4 5">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:D-serine catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
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        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
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        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
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    </dbReference>
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        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2500491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="368" mass="39881" checksum="D5ED355EDDCB26B9" modified="2020-06-17" version="1">MYSPKVGDRLESLDTPSMVVDLDIMEENIRKLMNLLKPHGVNIRPHLKTTKSPILAKKLIAAGAKGGCVAKLSEAEVIAAEGVDDLLITCEIIGPAKVARLVELFRKYPKIRTVVDSEVGGTAINEALAASGIEEPIQTLIDLDVGLERTGIAPESALALAQHISTLKHLKLIGVQGYEGHLQHVHGREEREKECRASMAILTGTANMLREKGFNIQVVTTGGTGTAEFCATTPGITEVQPGSFIFMDSDYRNAVGTFFSHSLTILSTAISKSGSERRVTIDAGLKSLTTDSGFAEPLDMPGVTYEPMGDEHGWLSWEEGGTDLPIGARVHMIPSHIDPTVNLHDFYYAYRKGVIEEIWPVATRGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7J5</accession>
    <name>A0A6A6R7J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_523538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7J5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="529" mass="60415" checksum="BF0C4EF777777425" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7Z4</accession>
    <name>A0A6A6R7Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_535156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7Z4"/>
    <dbReference type="OrthoDB" id="3929468at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="246" mass="26199" checksum="13F9E260E9FE82E2" modified="2020-06-17" version="1">MADDTPRNLFTSVFHSHSPSSSSSSAPPSSTHFPDGTPRTVYRSKNNTTGAEFSCTAPAGSKHAQAMRELCASVQSVGLPQPAQPAARYQRQLPATDSAPGMLTDARERVQTQGVDEGRGDGGGVGVIRTVSKATAGTRRNPRPPKLQYRNGNGGKVEGGPVFRRVEDERSVTFVSRSAQGEVFVAAPKGSREAEAHERMARGMVSLCGTVAREIEANEGQSGERREGPVKDVSNGPRWAIRWPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R931</accession>
    <name>A0A6A6R931_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_522240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R931"/>
    <dbReference type="OrthoDB" id="4520428at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="24683" checksum="D40743C98DF0B265" modified="2020-06-17" version="1">MPSIVVIGHLAAASKEAKRKLIDALTKVGHYSQAQEPGVVRYAVTVSTDPQDDLSVYAIEEYADQATVDAHLASDAVQELIKTFTTETSLFAAPTKVYTTETAFSFTRPESNKASNPYIVFATLDYKDGTRAGAFDGWKAVTSESQNNEPGTLAYAILKDKDQENTIRTVEVYESEKYLWDVHAKSAAVTNNKAKYGDIRTNLKFAFLKVVAGYLHKERPSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R964</accession>
    <name>A0A6A6R964_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">BU16DRAFT_547180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R964"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2500273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="236" mass="26693" checksum="96D37E95F76C43AD" modified="2020-06-17" version="1">MESDDEIPQLSAGALDALKEFYGDRDTKQKEFEDLKAQAENDFDGGKKLSMEAFTEDWNASQFWYNDETATLLAEQLLDGATDESSIVVVSAPSVFIQLKNLLASGKHTCRPQMTLLEFDERFAVFKEFAMYDFEHPMRLPAELKGKFDRIVCDPPFLSEDCQTKAKSWTTAPAENDPLRLIVCTGERMESLIGKLYSKAGIQTTSFEVKHAKGLSNEFRCYSNFECSAWEWAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9Q1</accession>
    <name>A0A6A6R9Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_556930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9Q1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="269" mass="30009" checksum="0AB86BAA6874F396" modified="2020-06-17" version="1">MDSPAVENTASFDELLDSVKYCETSMCDGGTLEFFFDGVDSDTINELTCAAPPVLTDEGKQQQTTAPHYFGNNPNAPCQNVVYNSPYNQNVFNTFYTHSAPVQDNTYTNNFHNQYSYNYPQFPPVFPPQGHFTPAYTIEGSSPSLAINVDDDEVVEIPAATTASLPSRGEKEAAVPNMNRVYSSWEPKAQMPGYIPKKGPVWGYQQKRDQQKRERRANKEKVRKKAADEKAMNEKAAEQDEGPFVSRAVDLALAVDVENQRAKRTKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9T6</accession>
    <name>A0A6A6R9T6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_522525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9T6"/>
    <dbReference type="OrthoDB" id="3532430at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="685"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="908"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127960" checksum="00FAA7E5A1857383" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R9V7</accession>
    <name>A0A6A6R9V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_199879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="55139" checksum="0269DB6D830011E8" modified="2020-06-17" version="1">MNSSPPARLLELPEELQDRIILFLRADFISLKLLRETCKQLARIAARHVFETVHIGLFPDSLEWFIMIAKTLGYAKFVKELVFFKDLPRKYENQEAWLNALSIWNTRWYDPNKGAVRQAQVEAQDLTAYYQRCLVYQEASAQLCECCDDHINSNNPMLESLNGFSSAIEKMTNLRSACVMEDFMHAFWSTYRKKIAISPTEWRDEGGNPPIEIDYERVPWDPQHDQQADWPNFDQSLNAKNKIAKIYPVFEVLTSLHVQMRYRAIEALSNPVVELANVVLRAKALQTLALDVGPDCLIYAGRSMDTSPDFNILNHLLYDGADNLRELPWPQLKNLTLGKFYTPEDTLFRFLHLLAPNLRGLYLAGLTFPKNQRSWKSFVSKLPTYLSLDYVRLDDLGSLAKNQDGFFPGPNDDYNVLQVSREKEFGLDDEDDHDCHWEHVQDYLLRRTIEMPIFNRFTFLKDGKGKCPIRGCPLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBM4</accession>
    <name>A0A6A6RBM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_423778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2501961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBM4"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8543" checksum="5781528188C03787" modified="2020-06-17" version="1" fragment="single">IFKSIARQLSPMDLIHLRQTSRGLHSAYDTAVKTQWGINRALQKFVKDPKAFRNKMGQMSSVISGEFALRFFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBQ3</accession>
    <name>A0A6A6RBQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCN5-related N-acetyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_3473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBQ3"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="201" mass="22481" checksum="3BB18FF45B78D102" modified="2020-06-17" version="1">MATAATIHLATREDVPTILALIHELAAYENETSSVLATEESLARTLSFAPSRVLRQSPTLPCPHHTHDCKELHEDSAPRLQTFGGYANTLLLTAPEGEVAGMALYFHNYSTWRAAPGIYLEDLFVKPKYRKRGYGKALIRELAQEVVRIKGGRLEWSCLNWNKPSLEFYEALGAKRMVEWVGLRVDGDALTKLAEGKEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC64</accession>
    <name>A0A6A6RC64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_554348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC64"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2502279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28400" checksum="05B5557100CE330B" modified="2020-06-17" version="1">MSNNQHTVVALKSAFLRAQTRILSQELRPSERWRDGAGSIPERIIRDVTLETNRLMRRHTKTAYGALSIRYVAEQIDQLYWNLAAPDIEVRDAIDADDSESNGVLRVGDDLTLDENIAKLPPTWEDASSDQESSTGDVATNQEGYLAAVTQLQSLSAQRQALSQKLSNYHTLLALLEPYRKPQESIQPNLVTRDAPLGTELAKTRTLAIRVAGRVQEKFGESREVDETETHEDEIVEDVLDDSEKLKDIMAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC91</accession>
    <name>A0A6A6RC91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_587709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RC91"/>
    <dbReference type="OrthoDB" id="5573651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="76" mass="8158" checksum="FDFE92DBBE137FBD" modified="2020-06-17" version="1">MAHQRPKRARSNPISASVPHHYKPASSLSVFSLALSSVVLVAAARSRRPHGVDSLKADTSTVRSPPCDPACQLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REQ5</accession>
    <name>A0A6A6REQ5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_23717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="136" mass="15570" checksum="06F39496E2F224A9" modified="2020-06-17" version="1">MHYPCVTMLLQCGCTQAFRFSRAFLCQTLSYQFLLFWRDSERMIAALFSSVRLRPRIQFLASRHHCVHCRRLAPCFVLPSFPRGRDARHQAASNWTVGPGRRNEGYELVSRTSGFCSRGASDQTSGQNPGTRIPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFG4</accession>
    <name>A0A6A6RFG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_555173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="321" mass="36072" checksum="4EFEAEE5402FBEBC" modified="2020-06-17" version="1">MPDVPRIESSYEPEWSKIPPSVLHKFQSFAAESVDWTTRESLPVSSKLPIEAALEGFDWSVQAQKVSETGEPLEGTPTEDCGSSMLEDSFPLAGDKSGRNYDKLRDAPGMNLDFPANANILAAEFAAFLPNARLAYPVAERLISNGFDYRVLAYMINTLRDMPNGFIETNSILKGMQITMRLGPQAGCPRENWTRAKQAEQIPDSWDENNVSTEGYQPRYRTHPNKKANLSTGPMRLVDPVPFKDLARGVQQFPQGKDCGDLTCCVRYHLRHPNEDWVYPTDFANLIDHIGGPMRISDHHTDYEAFMRWEAAMTSGVKPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RH95</accession>
    <name>A0A6A6RH95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_533132</name>
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    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2502827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="419598at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2502827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="310" mass="33975" checksum="5B07923D65A0970E" modified="2020-06-17" version="1">MSTMRIAVAGTCGLAKVISRIIQEHTSHQLLVLSRTPQPTLASQGYQCLIVDYNDPSSIHHSLMGVDTVISTVTGTPQLRLIEAAVQARVRRFAPAEFEGRPSLRLVGDPLDRGRAAALALLQHYSQNIKSTVFVCGVFYERFAVGGLASLGIGINSGAGGEGDYILDARNMTAQAPAYNTAGGYTSISMTSVYDVGRFVVRALDMIFWPAELTMCGERVLVSQLIQTVRQCRGRDFAHVQWHNPGTLNYELTLAQLAGDHARQRRLQALIATVEGRYDFALPGALNTQFPDIQPEPFQNWFARNWVGVP</sequence>
</entry>
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    <accession>A0A6A6RHN1</accession>
    <name>A0A6A6RHN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_554994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2281372at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
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        </location>
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    </feature>
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            <end position="191"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="196" mass="20753" checksum="CDE4F36A66C1BB18" modified="2020-06-17" version="1">MFVLFILVILAAACLADPRLYQRDDPPPTPTATFTSSANAAVTVVPAIPSPTQPGLTGSCISFYKVQTSDTCLSIAARNDISFAEFYFWNPSVGVDCSGIVAGYWVCVAVDTETPPSTTPTPTPTVVPAPAPTQPGLIASCNSFYKVARNDTCISIVANFGNKFTVEAFEAWNPSVGADCTNMWFDYWVCVGVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RIP3</accession>
    <name>A0A6A6RIP3_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2503357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    </feature>
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            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="722" mass="80357" checksum="CE2095797746CB5C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6Q8W6_9PEZI</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 269.34</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
    <sequence length="477" mass="52039" checksum="125D9469F36CA40D" modified="2020-06-17" version="1">MAWSQLEPSGPHLTYLTVPIFLLTYALFSLFIRNRLHLSEPPLATLFGILFGPKCAGVLRPEQWGFTDDVIQEITRLIVGIQCFAVGLELPNDYFKNTWRSLTMLLGPVMAFGWIVCAAFVYWIFETDIPTALIISACLTPTDPVLAASVLSNSQFSERVPLRLRLLLSAESGCNDGVSFPFLYVGISILTSATVGGIFKKWLLIHILYQCGVGIILGLFLGHAANRLFRFSNNRKIVCRASYLVFYLLLAIFSIGAASTLGVDDFLVAFGAGVGFGHAGNSPIREKNLPVVIDLLLNSTFFVFFGALIPWHAFTAGSDLVGITPGKLVGLIVLVLVFRRLPIVLALYRWMPAIKTFNEALFTGHFGPMGVGALFLVMEARAQLETDASIPLPHPPHNLPETKKRAVLLVWPVVCAVVLASVMVHGLSTLAISVVGHLARDEGERAPLIGAETDGLGGMVHEDSDEEVDERYENGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">F-box domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="40276" checksum="D4602531B8549585" modified="2020-06-17" version="1">METNTMFLQDADILLHLSYQPRHILDAVISVDESAKLSSTTVHRDSSLGRLDTLPLEVLHESLAYLDLQSLRYLSRVSLRGKAVVESLKEYGKIARVAAYTFKILTQAKILDLHSISTLCVALCSNRCLSCGEYGAFLILLSAERCCFACLIDNQSLWMISLPLARHSFDLTKEQVKALPVMWSIPGRYGDVFHQRSMAFSTVKAAKELALMVHRLPNISATTYLSTLPANLFEWYRQAPLDLLSQDPLTTTDEAIRPFDKFSGMGAMPFPSLVSGSTEAEHGLWCRGCEVTYHDSAIEKMDNSTLSELIPVGYHVDHIDRFLFRMKYRAWSKADFLQHAKHCYSATKVISQERTGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q9Z6</accession>
    <name>A0A6A6Q9Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_567338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q9Z6"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="238" mass="27068" checksum="5B4AC98BE3348188" modified="2020-06-17" version="1">MDEDDQAAREQDARDAIREFHRAPLKGLEHLFPHLFPDMFPDFQAPTSPALLRQSHADLANRRGATSSTNSTGQKKRTFTCSNCEKKYVSRERLRYHLEEARNRCTDPPDMTEEEKDERDEQFMVHKCPKCGKGCRNTNNLNFHSKTCTSTMFPSLPTTPTTPPTPIGTVPRLGHQPRQTALSQTAPKFRCYDCGIAYTSLSMLNYHKREAWDRCTDPPEMTAAEKDERAKALTSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAQ4</accession>
    <name>A0A6A6QAQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_567307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="104"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="541" mass="61778" checksum="08880021BC408CF1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAV4</accession>
    <name>A0A6A6QAV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Scaffold protein Scd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_472137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAV4"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="331"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="560"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
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        </source>
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        <source>
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</entry>
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="395" mass="42489" checksum="EB51B8878EAFBFE4" modified="2020-06-17" version="1">MNGTKETNGTSKHVISEESIQPEEFQQRIATVRKALQPSGLIGLIAFGDCWRGANVCYFTEFRPLDGVSDIANALFFLGVDSPPILFVSKQCVDYASEVTTFAVHSFDELNAHLSSFASKHSDGVLGLAGEAYIPEDLHRRIKATIGPLTLTPHPILAEIKAVKSPAEIALIRKASALTDIAMMAIQKTLSDGHPHTERELALDADRAMLAHGADRTAYDSMVQAGPRSAFNLARPTDRVVQPGDLVMTDIGARYRGYVADGGRGFTYGAASEERRAIVRAAAAAVEAGLEAARPGITCADLNAAIQAALVESGYEKYSSEARGHGTGHGTGMDPEEEQPWIGPGNRTVLRENMVFTLKATITVPGVGGLRTERIVRLTADGVEPLDVFPMELYW</sequence>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </feature>
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            <begin position="48"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2488827.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="204" mass="21570" checksum="60BA43FDBB28BC8F" modified="2020-06-17" version="1">MHLSTSTLALGFLALFAAPAAAASFSTTDMVCTSWSPRVIHDDDENDGCGKSQGGNHLPELVEASRLINKEMIYQDGQHIVCTSNKHYLFDLSGVCVFPDNTKGGISGDKITELLESLVAFGATDCGNVLIGYPAIKDGSKGMLRVDWVRQSQAGCKGRVCDLADPPLRNWKPPAADIAALSSATAAMLGRPSDGWPMLEGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBJ7</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="521"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2489003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="715" mass="79986" checksum="05EE4D012D8D8023" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBL1</accession>
    <name>A0A6A6QBL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
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    <gene>
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        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBL1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="428"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2489390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="714" mass="79836" checksum="261AE486553986DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBT4</accession>
    <name>A0A6A6QBT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_518511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBT4"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="366" mass="38698" checksum="B0A5BE08E69D4E6C" modified="2020-06-17" version="1">MPSYEIPTTCPAGVVTNAGPNFTLSIATVPVPTPGPTDLLIRLNATGICYSDIHYMLEDLPMMPSMSRFGVRSPGHEGAGVVVALGSAVTNWSLGDRAGIKPGYDVCFACELCWGGLETYCAEGTQTGLQHAGTYQQYIVSPARYTTRIPEGVSDFEAAPVMCAGATIYNSLKQSGLGPGDWAVFVGAGGGVGHMGVQLAKAMGMRVVGVDGGRDKRELCVKLGCEAFVDFLETKEVAKEVVRITDGKGAHGVFVTATSKQAYETAPFMVRVAGRVMCVGLRKWTLEMTPGGVVAGADPLWFVAKNLHIMGTAVGSMLDTQEALSYAARGLLKPSYEKFSLAQLPEAVDKLRKGQVAGRLVVDFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCQ8</accession>
    <name>A0A6A6QCQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CmcJ-like methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_519476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489453.1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489453.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34856" checksum="476F83344C84AA41" modified="2020-06-17" version="1">MAIPEVAVACLNGPNPSPARTDVKVSTVFYMNHLPLYQKEKPYFLNVPVDAGSELAQTNVGYTRQQIHVANIRGCEHVFTLDQTGFQLGKLQTKLTYEDFADSKAIAKRFFPEVQQFLREALGASEVLTFDYQVRRRDPSLPRNSRGAVGKAQPFASVHADQTASSAMRRLEYFHPEWFDKYKNGRVQIVNIWKPLHGPTFDAPLAVCDYRTVEDADRVPTDVVFPDYLGETYNFWPNPNHKWYYVDGQMPDEAWMIKCFDSKTAEDPDVSQFAPHVSFPYRDAPPGTLPRESVEVRNFVFYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCV8</accession>
    <name>A0A6A6QCV8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_544314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025572250" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="153" mass="16981" checksum="768B87B93C7DBF8A" modified="2020-06-17" version="1">MQYSSTVVMVLRTLLKVLLPYCEAALPSIAAGCPRKRSQGDRPVLMDRPAPLGYYIVEHINEMESNGCQMGNMLRASFENNGAEYLDVPSDGSRFRSEDASTVLFKTATPPPATLSEAQQRQQLLEVMERADALEAVDATLKKLIRTWFDIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD28</accession>
    <name>A0A6A6QD28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3941538at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
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        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="698" mass="75899" checksum="88EFFD1B0B89461C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD78</accession>
    <name>A0A6A6QD78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_470201</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="340962at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="CDD" id="cd20524">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="415" mass="46443" checksum="60EEBBCDE53FDBDD" modified="2020-06-17" version="1">MRLTEDEIYRSSTQFRLWSFTPGPLASLRATTNSTATQRVKAAVKRLRESRTQSETNSEAENGTSTPVNFNREPDCLTTEEEMKVVEAFCERAIKLGEFLKFPSNVTATGVQYIRRFYLFNSPMTYEPKSIMISALFLANKIEDNKMECSDYANSIPGTTKEQVLAPEFLITQALRFTFDIRHPFRGLQGGHMEMLAIAQGKAAVLPYVERTAGELQQEMLKLPILPGGVATKMSQHQVENRLLAATDKAKHTLRSSAIQSDAYFLYTPSQIWLAAYLLADEVLALFYLSTKFPSTIDAETPTGIAKLKVVATVRACASVLAPDPALQKLSNAERDAMVKQEVNAVKAILVKLRHCQDPDKMDLVKLNKAQKRDAGAEGKLEESVAKRRKLEREKNEKEADEFWGPELPKNGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDV8</accession>
    <name>A0A6A6QDV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_621935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDV8"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="250" mass="25690" checksum="7D6A326161196789" modified="2020-06-17" version="1">MVKSADKLVGKSVIVVGGTSGIGFGAASAFLDAGAKVTVISSNQDHVKDAVKRLDSPNASGEVGDVRDEAAFVALLQKLGPVDHVVFSGVDKIIRGALEDLDLENAKHLFGVKFWGAVTVGKAVKKHNIINRGGSLTLTSGTAALKPGKGAATGSGLNGGVISLTKGLAGDLAEKGIRVNVVTPGLVRTELWGKLGQSEEQQQKTFANTKLPVGFVATPEDIAEAYLYLAKASYSTGENVIIDGGARLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE13</accession>
    <name>A0A6A6QE13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_517433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE13"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="745" mass="83399" checksum="0544E1082F64E495" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QES9</accession>
    <name>A0A6A6QES9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_595162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QES9"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="610" mass="67041" checksum="984FDBDBB8E52A02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEU5</accession>
    <name>A0A6A6QEU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_574846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEU5"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="599" mass="66622" checksum="863DB8335002F682" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF82</accession>
    <name>A0A6A6QF82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BU16DRAFT_530796</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF82"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="347"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="491"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2490273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="608" mass="69135" checksum="9EB5BA5EF27ED4B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG10</accession>
    <name>A0A6A6QG10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_530687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
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        <location>
            <begin position="30"/>
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        </location>
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        <location>
            <begin position="309"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="38345" checksum="E190FCED776E4C64" modified="2020-06-17" version="1">MGDTESFLHLARPLGPAPVGAQPSTAPLSVVIQPQAVFSILDHSLRRPADQDRVIGTLLGTRTEDGTEVEIRNCYAVPHTETAEQVEVDMDYQKQMLALHLRANPREVLVGWYATSSELNTFSALIQNFYSQQGDGTFPHPAVHLTVSTVPGKDIEARTYISAPIGVTAERAADSCLFIPVPHEIKYGEAEKSGLELISGAKDREDRSQGILTDIEALERAVQHVLDMLERVSNYVNNVLDEEATPSSALGQFLMNALSLAPKVDPQDIERDFNNHIQDVLVVSYLANTIRTQIDLSNRLATAALTMGTGDPLGGAAGDGERKEGGGGRGRGGRGRGGGNRGDRNNNRDRDNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGP1</accession>
    <name>A0A6A6QGP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="234" mass="27245" checksum="7582FB5B9FB90F5D" modified="2020-06-17" version="1">MCHMLEVKNFQDPPELARWKRYDHVACEVGLPGEEKERFMISRNAVGEVWEPTSPFRRRLETPQDTSPDDDEPQTYNPPELPGVDRAFDELFDAYVFATTYDCKGLRKKIVSQLEDCWGSDTKVPSASILTSISQKLSCHSPLTQFFFFAWAKDVNPERLDQDDRREIESLPPDFLYEWLVVEKRVSMAREKDITGGKWSDATAMLEAMDPCQWHEHGDDEDEEEECREAREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGT9</accession>
    <name>A0A6A6QGT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_469008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGT9"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44868" checksum="2818C12F6AD98D5E" modified="2020-06-17" version="1">MAETSSVQDRRESSNDGDMILDNALIIPDLDFADVGGEHFDWSANDITFTDLLNPQPNDEPVQYPSSSSSSLVRHSTPSNDQAARTRQAMPSFSVSIPKSPTFAVRSLTQRKRITTGTQRIANLIFHTLKSYPLTMLRHNTLPPFIHPRLISSDEEDNHMEPLTNCISLVHMISGGVRGSRKLFWKNVALECERLHEEHATLNKWGLLASMQALSIYILIRMHEGETDYNNFDILLLGTVAIIAKRLANMIQGDKESTLSNYGLEDNWKEWLYEESRTRLAVVYRVVNLLVYFEPAAMCHLQKDLILAPLPAKKQLWEANDESLWKAESERDPDAQTAFGLAANGDLVQLHEGQIFCSDARLFYTPSDGSTPPRGAASWEEWCSGMDGFGGLVMLAASLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGW7</accession>
    <name>A0A6A6QGW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGW7"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="44967" checksum="DB7147E1EECA5226" modified="2020-06-17" version="1">MSDLTTTTEWIWSASYNDHYRVCYDAERVPVYKWYKDSQSDTRFTASSSVVSAQPTGNPDWIWSKEHNRHYFQDSMGKCHWEKSVQVPLTPHYNRSDSASTIGSRISSTSGGSNSSQTALVTGNDYTSVRVFLIGWQQSDINNLPAELNAIGDTFSRKFGFETLRHDLNNANPEPGLRDFLHGNNLLPGSEGMNSPQRQKELVIVLHGGHSDKMGNFSSCGQFCKDTNHHHGPSLKWKPFQENLIAQDFDCLTVLDTCFSGASARGISSKNMLLAASEANELSYNTSDEGYSFTEILNLELRRLADEGGPVSVRSLCVDRLYPRYAHQKRCPWPHRAHKNLRAYQFRDANSVRPECGMNVCQNLILRSTPNCSSLPEDNDSIDITFSPLLSAPIKYRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGX7</accession>
    <name>A0A6A6QGX7_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BU16DRAFT_584717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGX7"/>
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    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2491441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="169" mass="18213" checksum="94969D16D0ECA3D5" modified="2020-06-17" version="1">MGSMGEWWIEIVTLGTGWRIKFDGNNSGWSGRIVAWGRGGIEKPQWEIHGGSKQANHSFDGVGGLKATGWEVWIERKLATIGMEKVQTLGEKFMMGWLCGGSKDALLVSNGGGSELLALSSTWGGEVCCYGVWVGCGGSTHRGARFMELELEQHIGPDEHLEGVSTSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QHI1_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_493170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Secretion related GTPase SrgD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
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            <end position="81"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="271" mass="28766" checksum="70730D903CA88F42" modified="2020-06-17" version="1">MSQPWDYIAKIVSLGDSGCGKSSLTVRLCEGRFSPHHDVTIGVEFGSRIVSVGPPASLALGINNPSAKPSTSSDTYPTSPTKQQEQKHMKLSLWDTAGQETYKSITRSYFRGASGALLVFDITRRATFSSVTAWLHDLRQIAEDGIVVVLVGNKSDLAGSSLVAPSTGSQDPSTSGKNERQVTIEEAEEWCQANGVMQYVETSAKSGEGVERAFLEVAERIYQNIEAGRYDLNDRRSGVKGPGAGGGNTARTVNLGMNDAARGKAAGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHZ3</accession>
    <name>A0A6A6QHZ3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">SRm160/300 splicing coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_101578</name>
    </gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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        <property type="entry name" value="PH_24"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24345">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="875"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
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            <end position="1613"/>
        </location>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1878" mass="203903" checksum="55218B3B475F490A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIA5</accession>
    <name>A0A6A6QIA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIA5"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="245"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="40408" checksum="D88A0E2F7B4A6B7E" modified="2020-06-17" version="1">MPITFGAVGDIISLCQILRDLLETLDESRGSARDYQKAVDDIRNLQRLLSTLKDLTATCDNSSGYIALGQTARLKAQDCYDLIVAFHDKIEKYSKHLGKSRIDGGNAVREAFWKLHWRNSHMDCVEQFRTDIRDRTQSITVLLVSAHLNSFIMTDERLRSQAEETCSRQEACSAQQSAELEALTKRLEQLEGRMIAPCAEWLCALTMFREEFLQKLRNICKISYETWKGVTYINSQLPRLLEPWSEQPIIFDDAIGRVTRMPLELVENWDIFENVLLARFRGMPGLDRIAGKQYVLQDATTRKEISRNGPFKCSFRPGRRILMAALFSDDAINDQCCPSCGNLNAGNADDHITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIV9</accession>
    <name>A0A6A6QIV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_565091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIV9"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="401" mass="46107" checksum="14EFF9BC524B1414" modified="2020-06-17" version="1">MQIIQYRNEPIGSVVLRQVSQAIFIKFPKAIITFPYYVISHMSKYSIKTVKRWRATDSRPSIAVGPPGVRPVPTPLPKTRPRALSIPVSAGDSKKGAISTFLGINPKRPEQHTSPQSACSLLTKLPLELRLHIWTLVVGGQRLHIIPSLVPSLTRPPRYTLVDPGVFYRLDYERCKWGEDDWVGSSSVRNAHSACAVWVTDGGQLYFNAPRVLLEGDAQYKDEEYRYLRWWVRKNRILALVKTCRQIYTEAVPLLYKSNTFDFRNLDVLLDFPKTILPHRFQLIRNLTLQFIFMLARAHRPYQVSSAQAKARKDLEDWQKACAVLAQLKNLRDVAVLLGDRREQQGDGWKRVVLEALGQVRVNGRFVVRLTWRETEWEKEVAEQGALPFEIGRDFIDYSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ12</accession>
    <name>A0A6A6QJ12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_552322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ12"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="34721" checksum="21C7452266E6A350" modified="2020-06-17" version="1">MQTDSIPPNGKRIVFTGGSGKAGRHVIPELIKRGYEVLNLDLVPFEDPKVFTLKTDLTDSGQVFNGLTTHFDFTGYDGPTPPGPPDAVIHFAAYARNMLVPDNECFKGNVVSTYNVIEAACKLGVKKIIIASSETTYEVCFGQGDLDYQSFPLDEDYIDVNPMDTYAISKLCGERTARGFARRFDVDIYALRIGNVVEPHEYARDFQKYVNDPACRKRNAWSYIDARDLGQICDLCVQKDGLGFQVFNATNDTITTKIPTKELLAQFCPNTPIMREMGEWEAPLSNRKIREVLGFKEEHNWRKYYNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ71</accession>
    <name>A0A6A6QJ71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_564930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ71"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2492478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="291" mass="31944" checksum="68B0AE0ED8FEA8D2" modified="2020-06-17" version="1">MSKAGQKPCYFLAPTRTCPPEGPIRLGSIISSPSLPDEPINTMPLPLEASAIHTHNQTNWTSCHAKTKSGRIGVWGSFLQFVVGAGGDVSVGWKNEDSQLLMAKNMCTRYFVPSQEYVRATVMEDSVREYIINNKFRERLFMITGVMIASGASGLNSYMRDNGIYAHVGVDATIPCGVPFAGGPKFEGHQTTKTDVAFEGADDFVFAFRLRHIKVKKTGEVSHKQYNKGALYDLDGYKAMYEKRAQEELELGFEVEGLAEDDATGGEFGLDGEELMDEGTGEECLCVVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJI5</accession>
    <name>A0A6A6QJI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_552425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJI5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="487"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2491843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="996" mass="109801" checksum="99EDC0A8DD6EEB58" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJP6</accession>
    <name>A0A6A6QJP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_565597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJP6"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="38"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2491903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="373" mass="42231" checksum="59316A1C96E301D8" modified="2020-06-17" version="1">MTIDPNSKNNGIEKGSSKSSKESVDIAHSGVFYLLPLGLRVQEKLERMIDKHMRSIGASKLSLSSITSEDLQRRSGRYSENAELLRLKDRKESGFLLSPTHEEKITTSAAGIVKSYKDLPLRVYQISRKYRDERRPRQGLLRAKEFLMKDLYTFDSTPKMALETYSSVRKAYAAFFDELKIPYVVADADSGAMGGNLSHEYHFVSPIGEDHVCSCNKCHYVANEELAEKGIRTQKTPSNDPIIWHGMSKDRNTLVRVYIPKAQPLTQNEGEDAISNHLNIHAVKAAYPDMDTSIENEALERFGDTAPHLVRIFDHPTLLPEQDDFTTQPITTHPKTAKPLDLTRIHTGDPCPRCLEGLLTVQRAMEAVFWQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKJ9</accession>
    <name>A0A6A6QKJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_564408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Gonzalez J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 269.34</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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        </source>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="388" mass="41869" checksum="E7FBE8DC3477CA7D" modified="2020-06-17" version="1">MENNDRRQRQNTAPGYAGQQGLYNPAAHTSRTGSLTGQSPTSAPSSGNARSAYAYPAYGDSSAQFVGIQPAYTGDYPSSEQQQHARPSGQYPQYGQGLMYNTGAAGAATPASPYDASVAPYAGQPRHQSAAIEVLSSQFGVPQQYYNVAGDAAAATHSAGAGGPTSAPGLVHNVTSYSQMGYTTQQSPREQQLQQPSYAGGMTDPSQGASSASFGYAPAGGSTQGSEFDTAYNQYQTELKRTFQHVRDGRLGEAATLLMNISNWLLGNAEALGLVRDDEAMHTERLKLWDEFNTCWLTTLQQQKNMLETGQRPQPPQSIIEYDSLEEMGKQLVHLCDNMEKHGLVDYQMGVWEEEIINMLTTCLDMLENMSGSAGPTQRTLSASARRR</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
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            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2494010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28599" checksum="F721E8C0DF68089A" modified="2020-06-17" version="1">MPSRSQISARYSRTTLGSKKTFEYACVGAGVATNILFFVGLLAGSMMPPLAPAHTAEEVVSHYKRHLTGIRVLATLVLWSGPLYVMWTAVCSSQMKRIPGVPHAVTATQLASGALGAVGFYAPAILFATTAYRPERPPEITMALNDLSWIFTVFGFTPVVTQNVAFGWAILADLRPKPLFPRWLGWMNVILPFGLSPGMGLHFVHHGPIAWNGWVTFWLGFVWFGGLTGANIMYLILAIGNDMERDAVEEVVVEDVTKRNC</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
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        <location>
            <begin position="9"/>
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        </location>
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        <location>
            <begin position="11"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bills G."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQE0"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAF2494611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="129" mass="13289" checksum="32BC4198F02871D0" modified="2020-06-17" version="1">MASGLFTLLSLASALPTIFDAPVSLTIRPGTSADTCKILICSDPNSSGQCVDITGPAADCISIASDIGPQYSSSASTFVIEDGCICTLTDNASCYQNGAARSINLSGSGSTNLNDEGFDNLLQSYICFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QQE6_9PEZI</name>
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    <reference evidence="2" key="1">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </location>
    </feature>
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        <location>
            <begin position="97"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="187" mass="20193" checksum="44A483B8F25F3634" modified="2020-06-17" version="1">MAILSPRYFAQTVTEFMHAKRSRFTHACLPTPVHLLHPAPHEAASVPGSAAWLPQPRASNGRMLDGMPALAPRVMQAAVAGALRLLSRRRSPSSAAVISNRSQKPSPPKQTLNNDAAAHQIALHGTRPEAAPRAAMLWMSNEFPAPLPSPDPHRSSCTPTISRQLYLASRCLIHSPQWPLTETTAAG</sequence>
</entry>
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    <name>A0A6A6QQX6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="88"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="170" mass="18999" checksum="6AE540349C945D5D" modified="2020-06-17" version="1">MGNLPPADGGFILRYYRSTWGWVEHAWGLISSSSSLEMLSIPSLFSFLLLYPLPPTRPSPSIYPKIRNEAMFFFTPISAPIVQVHLKSDYNPNHDSPQRAQSAKTPDTPPQSYSFAQPNGIDFSSWAGFGAQDRSNEVGGSGSRGSLRCLDGRWKKVGFNRNNQERERDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QQY9_9PEZI</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <begin position="807"/>
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        <source>
            <dbReference type="EMBL" id="KAF2494805.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="846" mass="87889" checksum="F099EE29A8A583A3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QRE6_9PEZI</name>
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            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
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    <gene>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR45700:SF8">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QSR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3792203at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2494783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="173" mass="20081" checksum="1C7C3A463A5FC94E" modified="2020-06-17" version="1">MRQISAGHDGSRLDLRTFVSLANIKIPFYYLFKSPAPHESRNGAYELFPHSMETLDIYFGLRSSLLHTADEDREKMIGPHAAFEPWTYEWIIQFAHNKHRCFPKLWRLNAEEDTLGNPRTESLVEWSGTELQTKSMREIWDSAGISGTISFRRFPSNRSVRSLIHQSNPRADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QSW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSW3"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="438" mass="48017" checksum="E7D6CD52FE13E351" modified="2020-06-17" version="1">MVREHHSSSDPPKSARHVPLISSSSTPKNMAATRSHAPSQHGKLHKRGNSASSINNPKTSSELAGYNFNRFDTPRATYEEPWEPPRPTPAASNPLKIKPYLRKLSVKDSNSLDLSRPAAENERLAGLGIHEYGASSRTASDVSFAPVNSRSRHNRSTSNTSQFSTSSSLQRPTAPYMPLRQTSRPYTPPQSKSKSSPASMIGSDGDEADDIMSDEEMRYRQNMFDPARRSGSISSTQAQALRVTTSGSSTRLGSYSQTSLSIASPQTRPRGDTLKSIDTASPSSRPSLDKAFGFIRGGRDSPVDPASRAASIRAARQAYQEKEAAKDAKAEKEATKQADRENKKKYKQEERQRRKSDAAEKRTLSASQEKVAASVAGKEYSNYAPAHSRSLPARVATVDPEKENHAAPPITGRRMAKGRWANFVTWFRTRMLRLVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTK6</accession>
    <name>A0A6A6QTK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_528383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTK6"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="525" mass="59132" checksum="3F349E146F7B4F91" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTP2</accession>
    <name>A0A6A6QTP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell differentiation protein rcd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_460217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QTP2"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="365" mass="40241" checksum="078AA7B3F5372BF8" modified="2020-06-17" version="1">MQHVFSHQQQFQGDWAAGHHQHPAHHIQAQQQAQAQAAAAAAAAAQQQNYARIGANNNVSGLAMGNMGPGDHGAGLLTAEQGISEDNRRVLDWIAQLMKPATRETALLELSKKREQVPELALILWHSFGVMASLLQEIISVYPLLNPSQLTAAASNRVCNALALLQCVASHTDTRGLFLSAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNDSSEVINFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDTGLAYICQTYERFYAVGTVLSNMVNQLVEQQTVRLLKHVVRCFLRLSDNARAREALRQCLPEPLRDATFSSVLRDDAATKRCLAQLLINLSDNVIDANNQGMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTZ1</accession>
    <name>A0A6A6QTZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_608595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2495978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="44401" checksum="90DC357F785CAC90" modified="2020-06-17" version="1">MSTTTRAKACRSCIKSKRRCTREYPICKRCTTKQLNCHYDRLPPKPTPQARLHTPSATDASLSPSASLAPAPEIFQPQNLPPIIPPDTFSLSNPTNPDPFFTPEDLGLSISHATLKFYVREIRSWASQWISHGRTPFIHSHLYHPHLPASIQDAYSGCTLYFARNARNEALTFQILEAHVEKLVRVNTSCGGDGEPSSVQEHLARVQALLISLILRLFDGDVRQRAMAELQLPTLERWTREMWAGALAAFPGIQADEEGRADAAGAGEEEWRGWVVQESARRTWLTANMTLSVYLTMKQGWSGCPGGLKFDASRAVWEAPSLWLWSKACKDTQKVDLWVDTWDIGSLMKRCGAEDVDAFGRLLLVISLGLEKAEAWIEAGREKEGTPLVVCGGEVVEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QU18_9PEZI</name>
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            <fullName evidence="2">Putative ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_617432</name>
    </gene>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="148"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="285" mass="31234" checksum="BFB1D1B7D1318426" modified="2020-06-17" version="1">MKAQKIAIMLYATIKSILLRIGLTGRVSLLMVKGALPPTIALGMYRSPKVATVYGNFGFLISLASILSLHLQPRARFQQNIALATLLTCLAAAVSILSHFSGLQARKHTEALGQSRGSYNSSASVVNAIFLCFVIWLVSALRAAWPKVTIPFLICTIYSIVAITNGPEVRSEHKSLVLCKQLLLCYLTGFGISTAVSLLFFPITSRSVFLDGSHRFVMLCRDLLTKERDMLKAMDNRGDSEEARKVEYAKQATAMKTSAMTMLGSMSALREELSYAKREVAFGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUE7</accession>
    <name>A0A6A6QUE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_610213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUE7"/>
    <dbReference type="Proteomes" id="UP000799750">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025346643" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14992" checksum="64D521107847ED1D" modified="2020-06-17" version="1">MFIMYVVGALWGLATVLVDRHRPIDLLEPARYLLAKTPKEAIKSAAAILSNTRLIFSSSSQSLSTKSASNTPKLTLSQALRHRNVTGSIGSIGSIGSIGSIGSIRSIGSIRSIGSIRSIGSIRSIGSNKNSRSNRSNKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUU0</accession>
    <name>A0A6A6QUU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_538552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUU0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BZIP_BASIC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2495939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="277" mass="30880" checksum="A31D5D704445BB40" modified="2020-06-17" version="1">MQRHASYGYAQTAPTTHRYSGTSSAFSASANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKKRLEDLERRAASSSASPEQQPAELDRSNSQPREEFHSPSSSDSVDHQDYGRRTPEMQTQYLPHHEERGMFSHQYTRQLSTSPPPFSYSTYPAPDAVSYAPYAPAYNGLPTTGPEMPMYSPYLPPLSSAYPTTLPSLVHPMKGDFYGEDDISPFSMSYATMAGIEIPAPHSYVSDAHTPPLLDSFDRSTTGSPPDSATYNPTTPNSMPGTPPLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV14</accession>
    <name>A0A6A6QV14_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_459841</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV14"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
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    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="34698" checksum="7ABF67336C39EB73" modified="2020-06-17" version="1">MLLSQQALYNTELISACKKRKNVTNPCMPPNLIPKRDPTHRIAAIALYRALLSQCAAAPIAHEIQSPLRNAIRNRFRDNRVLQSPRLLEIAFRAGYEAIDLLDAAVAGDADSTKTLESLVAELPNNLVRERKAPVKIPKEDRKPHILDCLPPGFKALEERPRPTVSGRRGIPKLASATGVPFLRFTKPQPRNLSRIIRQKLEDKIKRFEDRVVHSNYWLPLAQQEDAWDRLVMGRARADESEPSWAEEHHVALREILRKSEEKKEEATRLADLMADIVEKETELARAEELARKGGTKGVVKGTASKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV53</accession>
    <name>A0A6A6QV53_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_366347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV53"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="553" mass="59884" checksum="38C9B29F2B236652" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVK8</accession>
    <name>A0A6A6QVK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_462770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVK8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2494947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="53367" checksum="43AA886C9AC1A696" modified="2020-06-17" version="1">MGKAYNWMCAGIAGSGSMLYGYDAAVIAGTFAQPGFLAYFNPSATVLGAIGSIYFAGLLIGLLFVSALADRFGRKRTIQFGAVVGLIGAIFQTAAHEIGLFFAGRVLAGIASGIMLTTVNVYQAEIAPPDLRGTMVAFQIVTLNLAGTLASWVGFACNHSTNLAFQWRFPIGLQCLPAVLLIIGCFFIPFSPRWLISKDRHAEAQVILKRLHDSHHDSTFWEKEYIQISAQLEVEAKEKETASWTHMFTNWNELRRLLIAIAALTSVQTNGAQTIQVYQSVFYAGLGFTTKRILLMVGIFAICNTCGGVTNLILIDRVGRRKLFLSGLVILSVMLGVFAACSERYTSTGNSSWGKAGVSFVMVYIFFFGVTYASSPYAYAAEILPTKNRANGMAISLFVANSITLTFTQVTPIALNKIAWKFNIVFIACNLFFLPIVYFFFPETKGLSLEEVNGAFGERVEVEFKDITDGEVEKVAVVQLEDTHDAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVN9</accession>
    <name>A0A6A6QVN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PAD1</name>
        <name evidence="8" type="ORF">BU16DRAFT_378252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVN9"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="72"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2496465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="277" mass="31112" checksum="F61E04AC0DD4AFC1" modified="2020-06-17" version="1">MIVQKTLKILAQIPGWNRSLSLHRTVPLAHKQYLRHFSADGHRLTIESNEIQSDRPHDEKSTPPTMPRPRRKRIVVAVTGATGAPLATSLLLHLKKLDVEMHLILSTWGSATLKYELEAPNNTAAYLASLAHYSYSPRDVSASLSSGSFRTDGMIVVPCSMKTLAGIRMGYDNDLITRSAGVTLKERRRLVLVARETPLSSIHLENMLEVTRAGAVVFPPMMTFYTKPKAIQDMVEQSVRRMIDLLDLGFEDHIHADGDGRWNGFEWKKKMSDEKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWG6</accession>
    <name>A0A6A6QWG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWG6"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="163" mass="18554" checksum="9E705D3E0C03EA22" modified="2020-06-17" version="1">MANLASKLQGLGLERYHVAFVENGFENWSTLSKITDDDLKELGVKMGHRRILQHEIAAERNKAAEELSSLQNGGALDETLGFREYTRRFLAEHVRVVPEDRLDILDSEEGNWQDFLGKYGLCPSLQVCKLFWEGRVNTYVAERNSTGGLINQSARTFYLFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWN3</accession>
    <name>A0A6A6QWN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_560166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWN3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="223" mass="25266" checksum="A53E605AD1CB1800" modified="2020-06-17" version="1">MPFPFLWKRLPLCLPPSPQAFLIPPTPTDFQPCHDAAIYPPFRKSLINAPLSSFDLFSKVRTKISSAAALSLPAPQQGSVRDQSAADQYLTAGSSLKPQPAIHSYHPPQREAVAVRSDERMVWSEEEEDGENALDTSSVKDKLWKEEAAVEDFVVPEWERVGTRRSGRQEGLVDPILRTLDGWAEVFAMHSDKRRAQREEEEEEEEEEEEVGNRTLRRSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX39</accession>
    <name>A0A6A6QX39_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_538804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2496233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QX39"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="37943" checksum="426E8816F68EE377" modified="2020-06-17" version="1">MSVTPAVCRSHASRLSPRSLSLLRCLLSSSLAITVLLVPSLAPRTSVMLPFQFQTVYIRRPPKRRGRRPIRLDALSHPVSVAPCRRTAFCATSAILTSGERFMPFSLRAARPPLSLCALRNGVNTRNKSQAAPTQHSPSLPACPSAPAALAEGSLSGPRCIASSFSLVPKSAWLRPRRRRLGAGHSPDDDDASQLSWAAQSSRYACGRCSDATTANGGPTAQDDEAGVAHESRGGGVLRVVGSIRNTGTRWRSQAQRANLHRREAWGALPPFALSRTLFRCGSLGTYESLISVGENFSLPVSQVTVFMPSLYRNSALVECRLVQQALPLAGKDSAVSCCEKGPLRAAGSAYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QYS9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYS9"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="283" mass="31814" checksum="1D140763D0BCD997" modified="2020-06-17" version="1">MDSSSDDDYHESPAKRLHADDTPPKPSTPEPITPEPVTLANPSDLTLIVGPLGQSIHVSRGALRLASPVWNTMFSDQWAESSKKEVQFPDDDPEALLIVLGIAHLRFKERPKVLLYRQLVELAVICDKYDTVAVIRPFLQEWIGYEEMKVGPGTEEWIFVAWTFGIRDKFVNGVQDLVRNTLADAQECLVWPEQHVTLRLPIDLLDCISQARQESITKLMNLAFGHLDTCVSINKCARGSQTCIGNTMDEPDYHPPFCYVSPPILLHITPPRFSLAPARNNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ69</accession>
    <name>A0A6A6QZ69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_457685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2497304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="521" mass="58484" checksum="E4705C9CDE5F3904" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZK1</accession>
    <name>A0A6A6QZK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_457188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2497434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025368821" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="21"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="268"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="511"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2497434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="844" mass="89027" checksum="02F4E4AF5CEF1E90" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0K6</accession>
    <name>A0A6A6R0K6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_537485</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10254945at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="400" mass="45110" checksum="4E319AA204ECB280" modified="2020-06-17" version="1">MHAIFQNQPLADRLCSGEEGTGSTYSPAHMTENHAMYSKCYQGNKGVIMPVELDNIIHPVFDQANFDCDGHVYDAIKPALRLASLFITEEKILGWWTSVVQSKLTLEQPAIIFPEHSSSPELYQQRLKATLSRDAKIDANSALAGVRNRFNSLAKGTTFRFLKGSEKDADVFSAHGKQWWKSHGNPTIGLADTFASYAEDLHIRNEEREIEILEYLDSVQRKGDLDVSTVIPRTKYTAQDVCFLFRLAQTLTHELAHAFFALPWGNSLPEPLFKHDDPEAEIGLSWEQSVFGALPTASEYFEASCHCCESSVTIEHWGARVDAKDAADTMPPNSKRHLILPMSWVRDWFLKSTWAVITAQGPDAMQHPQPVSVIYQQDKEWRPANVVDALTVARHMPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R185_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="185" mass="19397" checksum="D5C9C1644CA5CC9C" modified="2020-06-17" version="1">MAQQPLIPHTLQLCSNGGCLLPALPRNHTLVAPSPRPVKAWAGLAKLGSRGPPIKCRDAKLIVACAGFALLVWGASGTGTLRCARALVLPPLYCTAKATINYFTNKHITSTKPSQCLAQSPPSSSPSRSRPPAARAVTAAAATRAAGASSCKRLGQPTNTTHHIDPSHFPSTTTSTSEMEAVWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1A3</accession>
    <name>A0A6A6R1A3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf1446 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_456315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10265871at2759"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR47585">
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    </dbReference>
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        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07287">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="499"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2498485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="613" mass="67871" checksum="AFF2FD7882A2B983" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1Y0</accession>
    <name>A0A6A6R1Y0_9PEZI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_303164</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
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        <property type="protein sequence ID" value="KAF2498711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1Y0"/>
    <dbReference type="OrthoDB" id="3630991at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
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        <property type="entry name" value="IBR_dom"/>
    </dbReference>
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        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2498711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="313" mass="35901" checksum="F88418FD6D134A99" modified="2020-06-17" version="1">MATAEEPECDYDSTEEAECEYECLVCIDTFPESKTVETECGHYYCKTCINQVFDNACSGQGVFPPKCCRPISFTVADTLLNEVTRSRTVERAKEWVEKSPVYCFEPFCARFIPGDTFQNNEGMCPKCHQKTCKLCKKMAHAGHPCLDDAADVAMVAMARLRGWKRCGKCHFFVEKLAGCEHMKCNCNYEFCYQCEKAWVDCNGGCHALALEEEIQAFMDLVHQPRRPLRPDADLLAVLPERHDFMPERRNSIHEPESCSHPQNEQEYVLGCNVNKCQDLGGCNRLYPWLTQCKKCSWISCDSCRTWRLENLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R242</accession>
    <name>A0A6A6R242_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_524456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R242"/>
    <dbReference type="OrthoDB" id="3791134at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="114" mass="11138" checksum="410914E6BC577021" modified="2020-06-17" version="1">MAPNDSWLTRTMNTATAGVGNFAGGVVGAVGTGVAGAGRGAGSSITNTSRTWGDSVRDYGNGIKDATGASGPRSGTANNPLGVGRNKESVRLSNQAKKGSGSTTKGSANNPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R250</accession>
    <name>A0A6A6R250_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectate lyase</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_505854</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R250"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000036">
        <property type="entry name" value="Pectate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025555413" description="pectate lyase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="14">
        <location>
            <begin position="54"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2497467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="34401" checksum="9761F16917818622" modified="2020-06-17" version="1">MKLSTLLVFGLSSLALAAPTRTQQKRGSLAKRASVTETPTTGYATQNGGTTGGKGGSTTTVSTYAQFTAAVTDDTARIVIVKGTITKAAQVKVGSNKSIIGQNSSAKLVGLGLYIKSKKNVIVRNLAISKVLAENGDAIGIQASTNVWVDHCDVSSDTDHDKDYYDGLIDVTHASDFVTISNTFLHDHWKASLVGHSDSNGDEDTGHLRVTYNNNYWYNIHSRGPSVRFGTVHIYNSYYLSVDDGINTRDGAQVLVQSNVFYGSSKPLYSTDSGYAVASDNDFGDGSNEALAGTLKTVPYSYSLLGSSKTKAAVYGTAGNTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2K3</accession>
    <name>A0A6A6R2K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_481478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2K3"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2498504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="54345" checksum="CD97A7F7D815AE31" modified="2020-06-17" version="1">MAEAEGNPTTWKFTQCFGDKGDVEDITEADIISTVEFDQTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSHELTPGSGVAPGTGAGGPVRNPNAHFRTAADLKLPRLTHHDTVVAAVPRKTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPQSCNWFMYASSKGTIKLADMRASALCDSHAKQFEQEEDPSSRSFFSEIISSISDVRFSHDGRYILSRDYLTVKIWDVNMERQPIKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAKNVMTGSYNNNFMIYPSDPEKDTEVVLQADKSAFKAKKVGIPTPMNSSTSPTGNKKGGSRAGSPAAGAVGQGQRMRKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3A0</accession>
    <name>A0A6A6R3A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_615774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3A0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="343" mass="38483" checksum="8A782FC2D5EE5DD8" modified="2020-06-17" version="1">MAGPTLTTLPAELRQKIIAETITITISTTTPVFTPLVHLCPPIIALGITATAAILLTLSTTNFTPFGDVCALLQADILALCASWLPTPTTPITLSQNTRASWAALAAFSTVVNARAARLNRRAWPGITTLTLRFLVPTSAPLDANLFESIDPPFKWAKELRRLPASVKLIKLDLSLPDAHMTQLCAQELSTQRVFWYECFRAVRLLDDEAKRRGIVIEVLGELPRSQVAALAPVAGTPAYFTIFGKVARMMLMAEGYYRHRWGVLEHCRQGAVLNGFVRRVRATKEWKEECRQDVLRGEIWKREYKKVIAELSRRMSALKKRKREEDGEELENEEGAKRMRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R3E7</accession>
    <name>A0A6A6R3E7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aromatic ring-opening dioxygenase LigB subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_454542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R3E7"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2499261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="284" mass="31285" checksum="D146322FA2F7A801" modified="2020-06-17" version="1">MSTPAANDSSPGRMPVYFLGIGGPNSVENTDHPAYAKLAAVGQEITAKVKPKAVVVFSAHWRSGPNSLQINAAEKTDIIYDFYGFPPHYYEYDYPYKGSPEVAEKVIEKLEGSGIQVERVKRGLDHGVWAGFIVAFDPKKNPLNVPIVQVSLYNNDDSDRHYRVGQALESLRDEGILIIGAGMAVHNLRDYRNTLSTKKTMPYAFSFDEALKEAATANPEEREAKMSALMRRSDAREAHPSLEHILPIHIAAGAAGSDPGEQLWTFPEGSLSWAQYRFGEFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R477</accession>
    <name>A0A6A6R477_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_503069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R477"/>
    <dbReference type="OrthoDB" id="3695626at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="75946" checksum="C27AD34667DE10CA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4V4</accession>
    <name>A0A6A6R4V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_480042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4V4"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="70647" checksum="E39A40D6E923C725" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5B6</accession>
    <name>A0A6A6R5B6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_535516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5B6"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="200" mass="22243" checksum="9DAD775502838E70" modified="2020-06-17" version="1">MSEHLFTTVDATSSCPICKNPFALHPTDRILLAAELAKNAYNADHLDLDLDILVRPQCGHDLGLFCLQRWMDLGHSTCPYCTLTMLNDTGDAASIQFLQPMSRGMPQEDDELMVAVNEILKAWEAGKDKQQGLLPTWWNGEARVVGMDRGMRYEYLAVILDGANARGSISHWGFDSASRDFNGRHLAFLGLGLRTVFMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6Y6</accession>
    <name>A0A6A6R6Y6_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_614080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="327"/>
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        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="661" mass="71227" checksum="C0FCD0EA695EE341" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7C3</accession>
    <name>A0A6A6R7C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_480491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7C3"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="296" mass="30946" checksum="C991A8CCB81732F7" modified="2020-06-17" version="1">MSSIKNVILIGAGGNLGPAILEQLIASSFNITVLSRKESTSTFPSGVKVIKADYSDVSALVAAFKGQDAVVATLAAPALGDQPKFIDAAIAAGVKRFIPSEFGSDTASAALRKAVPAFEGKKAIVDYLKTKEKEISWSAVITGAFFDWGVKVGFLGPNLQTKTADVIDNGTAPFTATNLATIGKAVVSILQHEAETKNQYVYISSFNTSQAEVVSLVEKLSGDKYPTTNSKSSDLYAEGAKKRAAGDHSGTYDQIKAALAGEGGLGDHAAAGLWNDRLGLEKEDAETTIKKILGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7V3</accession>
    <name>A0A6A6R7V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_523414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7V3"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="130" mass="13861" checksum="D026B00C266FD3C8" modified="2020-06-17" version="1">MSWQAYVDQSLVGTGNIDKAIICDASGKTIWAATTGFSIPEAERKVIVDSFTDSGETKAVVANGIHINGEKYITLDSDDTSLKAKKGKEGIIVIKTTQALLIGHHPADVQTTVAYSSVAELAEYLVKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R807</accession>
    <name>A0A6A6R807_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_277745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="7">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2499607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="150" mass="16833" checksum="BE782680F40CDE53" modified="2020-06-17" version="1">MGEPDIQTSNWRLVEVGRVVLFSSGVYEGRLATIVEIIDHKRVLVDGPSSDKDKVVPRQSAALSGLSLTPLVIPKLPRAAGNGFVKKIWESEGVESKFAESNWAKTQGRFAKRKQLNDFERFKVMKLKKAVRYTPFMRSTNLPRNVALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R852</accession>
    <name>A0A6A6R852_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_523549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R852"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1166" mass="129046" checksum="C5FDFA62907F7A6F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R879</accession>
    <name>A0A6A6R879_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">BU16DRAFT_522020</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="33926" checksum="A96B69510DF0EF16" modified="2020-06-17" version="1">MARNNRLEFECIVAHYNEELSWLEELAPDTIIYSKGGRRNTPAAGSWKDVRTLPNIGREAHTYLHHLVTHYDTIADVTLFVQGDAYNPDGRTPPHSTVSVPEMKSRSIKSNSTSGFTCFTPVVPNFDQWSGLPWESDPKFRWWFHKNGKTMLRAQLTPAEFWTEYIGGPHPESVWFASGAFFGVTRETVQARPKSFYEKLLKAFTDANHPNPEYGHYVERLWGSIFLDHEGALESRRGSVGSDSDDGSRTSEDSDVLTSRTEILLDIAETLPPLPVTQEEFAKKREMWMKEEGEAIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8F0</accession>
    <name>A0A6A6R8F0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_257118</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8F0"/>
    <dbReference type="OrthoDB" id="10351049at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="275" mass="32859" checksum="1E917E6323BFF66A" modified="2020-06-17" version="1">MKMVSAAERVFGIEEMREQILSKLTFYDLFTAQRVCRSWRDSIKGFCGRLQGFNDVQEAIFLKPRPAQCPDRPLWLDQPLTFDAPTNAEAATLIHWEFNECYHNHEEKVLCRGCSPLDDGLLHPIFRMEHLNPILRDNLTAGVCWRAIGDAIIFYTSDNFHLERFMRWCDRHKTGSWLDTLAFQPSVRKLVIARPLQGRRNEQWFIHILWFRCDTAMQMKHFLKPFLQADWLLPADRSCHTVMDPESLDWIIDDWRRMRYNRWWKPSRSIWMPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8M8</accession>
    <name>A0A6A6R8M8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
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        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4062651at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="298" mass="33279" checksum="CF914EA8C091197D" modified="2020-06-17" version="1">MADGEHKHTVYANKAELPYKHLDNLGRGSYALVDKVETIGSDPQIYARKTIRTRYFRAAAQQKQITSEIKIARRLRHDHIVRLIGTYQAGLDFGIIMSPVADMDLGEYLARADVDSGFYTQMDARCRLHKWIFCLTSAVDYLHGEKIRHKDLKPANILIKGDQIFITDFGISKDLINDATTGSIGFPSERTPMYCAPEANIEDARRGRAADMFSLGCVFLEMWTVASGKSLAEFEEYRIADGHVLSQTPLYPKLSLMARGSNLGETRKNTEKGSSNGADVSGDVNWSHSSIEEPQPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8N1</accession>
    <name>A0A6A6R8N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_453129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R8N1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="52516" checksum="05E9CBE9938C2F63" modified="2020-06-17" version="1">MCTAISFMLFGGYSDLFGRRWFIISGNISVFVGYILIGSAKSTQAIIAGSTCIGMGAGLCQLAAFALPELLPNRLRHIGVLIADLSTWVAVLFGPIVGRYAIRHGQAWRWLFYAPAIACCISFVLLVWLYKPPQHPRGIPFKQALRELDYGGGVLFTAGAVLVFTGVIYTQIVTSSDPKVIGLLVAGFALIVIFALYETFVPLKQPMTPPEIFAKDYGREFTFPFIAGIIVNMFFYSVNIAYPTAINVLWTNASTPLSYSLEITLPQNLGLIFGSVLLWIFGIRIGHWKYQFIGSFFIMTLFGGLLALMKPDNKAMIMVFVFICEGAYGWAQTLSITFIQMGVPQTQLGISGALAGVARWTGGALSQSIYLTIMSHVQASHAASLVPKAAIAAGATPSTAQALLAAIPLGAAAIEKVPGITTAIVEAAGAAFVQSYVVGLRTICLASIAFGVVGIVCCCLSNDIGPKMNDKIEVFLENDVQADKNRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA17</accession>
    <name>A0A6A6RA17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_599613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA17"/>
    <dbReference type="OrthoDB" id="4630416at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="285" mass="33932" checksum="05F7C16EBE2E9FF8" modified="2020-06-17" version="1">MSARTPQNKNRPQSQEERPPEERLVFAEHIKYMRKQHRKPIPKEWGFWRATGSYVIECEAVTGPLSDYYDNEKLTMDISETVKEGCWFFDADFNFGVIEGTMLMEMTPSLLDDVMKAHRKADGGDTAEEGDNDSDDDGWEEDEDPERYEMQQEKRRLKEEERRKAYIDQSDHGLERYPRRIYFQWRGRDMRDATPLIQPDWDNEHVGYLEFEDNKCNIFEGRAELGVIGSNAEFRGYKVDKEPRKNAEPWNDLSEKIYELEWREKVARDRRPPLRASIMGMERPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA97</accession>
    <name>A0A6A6RA97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_195823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA97"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2501312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="170" mass="18676" checksum="2F2A0D7D2DEE2E85" modified="2020-06-17" version="1">MLAASTCTSTSHNRQRKAPLYSSCIAHLYPPIASGHVTARLKKNLFSSASCTYWIQSRAPHAAAAPNPQGTAFTSPLIRHALQLPGLHGGGLAAACEIQRCSQPRCWVLFPVRRRGTRFQGWGRRQCGRGGEDGALVVESRLQLYGRQGTVFAPDSHFLILIRVYFECLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAK4</accession>
    <name>A0A6A6RAK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_444147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAK4"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="268" mass="29401" checksum="248A2E53BA38059C" modified="2020-06-17" version="1" fragment="single">LKLVAQETKKLLPFVLEQLQPVDTTTSTRYHFQDLQPLDPSTCPQHRLGENDIETGRLGTRIRVFDQDSFDAAIALQPGTTIGDSRKPVAVQNLASERRPGGGWENGALAQEEALCYRSSLYLTLKPEYYPIPPLSSVYSPTVIIIRDALARGHGPLVPGTDAKQLAVTSVLTVAAARGPMVSRDQTYFFNGDRELMKSKIRVTLRMAARNGHTKLVLGALGCGAFGNPPKDVAECYLEVFREGEFQGGWWEDIVFAVLDNVKGGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RB33</accession>
    <name>A0A6A6RB33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_203346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2501576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="159" mass="18014" checksum="CC5D045F24FEBC97" modified="2020-06-17" version="1">MLSRRHFQTLLQDIRYPCSLWDLLHAIYLSDLLIYFHTGSFSLIQDCTTLVPGLFISSPEFQLSPSSFFILKCVALVELRKFTCSFLSTSYSAITYGVLEFKYLCNEESLHMNQATLRDIPPCFFSAFRFTALKGCLGPLIHARAGPTSLASYLSGVFR</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="166" mass="18758" checksum="744E8DBE057A77AF" modified="2020-06-17" version="1">MSITRGEPVTHARLKKELGDVLPLPDASVKQLWLASHHLRQHIASMITCLRPRYVAVNVLTARNPAVDDKDKSRYSAAIVGRRDNARREEEVICGPAYGNSRREALYGLLDTVEEKVWEWLHPEPTEQPQGDQMEENGANSEERANKRRKPNEPTGLTAVVREMGI</sequence>
</entry>
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    <name>A0A6A6RCN7_9PEZI</name>
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            <fullName evidence="1">F-box domain-containing protein</fullName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <property type="entry name" value="LRR_dom_sf"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="429" mass="49781" checksum="7A69C0A7CC1822F7" modified="2020-06-17" version="1">MSDVIPYKFSISNASPPPAAESEFYEKMKKIMQYYRQHAALPRGDNIGPLNDPEMLLLMHKYVLENLHFHYIPQFGPLCVPLERREDTLQEVWQNWHLKERDCLVVTAPWIDIELNGHVIVEKVSLSMVEKIGKYANKPYKQMEGLPRGLYYSRIYRIRSDNPYLPAAIRLVVGWMEYEVLRPGEFYFGERIDPYEDVTLRHSLAHALRALGLLAEAQRMDDWYKFHLKRPTTRLRARDARKIWHAEGKRTNNVYVEELAKHLARTSYRETRGGARSGVDFPLDFGRNAQMAVFLNEEGNERLKAQVVRWDPTLSDQEASDVGGDGPDVVLGVQEEQSDLAEETAEEGGDGRRVRALRDDKQQKIYRERLVVQGRRYSMPSPEWYGKKAEQRDNVRKTLGRVLVSKTPLKTLRKLGGTAWSDVDRRPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0016788">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2501780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="46114" checksum="46B102AB8603EAE6" modified="2020-06-17" version="1">MLSYILNLLPLTPFTPSPSTISTIQTPSPLIHAASTAQPALSPVSNIQGHAYNRFIQIWLENTDYSLAAGDPSIAWLSTHGITLTNYWAVTHPSQPNYLASVSGDHFGLSSDGYIAVPSNIATVADLLDTKGISWGEYQEDMPYAGFKYISYENPQNGKDDYVRKHNPLIMLESVTQNDTRLSLIKSFTSFASDLAAETLPQWAFITPNMTNDGHDSSITTAALWARRFLKPLLSNAYFMKDTLVLLTFDENEHYESPNQVFSLLLGGAVPEASKGSEDDTFYTHYSALSSLQANFGLPSLGRWDCGANIFALVADKVGYANWAVDTTGLDFSHSYPGPMSPIESQQAWPVPNTNAKCAAGYGVLGKVVTAWGKSDGSLNYTNPYPYDDGSGTDAGGSVSSPRNAPASPPSAPYPHPTSHTRSLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF40</accession>
    <name>A0A6A6RF40_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_6223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="958"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2502363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1191" mass="128398" checksum="2651940CE8D99F02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RF65</accession>
    <name>A0A6A6RF65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_554451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="5">
        <location>
            <begin position="449"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2502390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="656" mass="70230" checksum="C96C6FA4712F5D28" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFA3</accession>
    <name>A0A6A6RFA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFA3"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="131"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="380" mass="43487" checksum="AE69385857A6E974" modified="2020-06-17" version="1">MFPAKMSIIPQKPPPMYGMPSPHPQKTCRVCYDPLYGPLDGLNHLLAHRAAPRSRPYGWASSLFSRFDSLLHSKSQQKVRATQRTQFDFKRLCTVRTGVGPRVKPPIGLHRSRALTPPLSPSKSFNQSNKPQAQSPLFALPLEIREMIYEEAIGKSNVHLEFRDELFCYKLFCHTLCPEPEQGVCGCRYLKRRGPKRQLNPLPLLLSCRIIYSEAISLLYSSTLFSFRLDVSGPLVHLPDLLLLQRFHAIRSLYLFWAPRWEGGSIWSGPLSPSIEEWELAWLVISSMKGLQNVYVDLAQTRFVSLHPESLRERWQEMQPQILGPVKTVTTPLKSFRMVWPVEGPVKVEVGGRIWQLETLDQETIAIDKQLGWDSWGFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RFT6</accession>
    <name>A0A6A6RFT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_521928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RFT6"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2503344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="488" mass="54416" checksum="CB726E0DBD6FC99D" modified="2020-06-17" version="1">MAENASTGLGEPPSVAALSVAETATTPAKHLTEQEINPWDVQAGTDEHGNTLEFDYVAISQKWNTKLLDKATLERFEKLTGKKPHRWLRRGLFFSHRDFDLILDCYERGDPFMLYTGRGPSAGSLHVGHSIPFEFTKWLQDVFDVPLVIMLTDDEKFLFKEGLTVEAVKQFSKENAKDVIAMGYDLQKTFIYSDFMFMGSGSNGHFYENSMEFSKLVNFNQMRGAFGYDGSTSSGRVFFPNLQCVAAFASSYPFIWGDDIEADRKATTAAIPCLIPCAIDQDPYFRLVRDNSLRMPRPSPKPALIHSKFLTSLQGAGGKMSASVPMSAIFLDDTPNQIKKKINASFSGGQETLELHQELGGNPDVDVPYQYLCYFEDDDEKLDRFYDAYKKGEMLTGEMKKECITLLQSYVKGFQEARAKVTDDVVKDYMKPRKLEWKGNPNPTKSPQKAEEPADKADAEGQKGQGKRAAKRAAKAAEKAAGDASKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGR8</accession>
    <name>A0A6A6RGR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_521551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RGR8"/>
    <dbReference type="OrthoDB" id="5059029at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2502903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="90" mass="9356" checksum="81FAFE8FE9ED9A95" modified="2020-06-17" version="1">MTWQVYGEGGDNCDSTAQLETIAGAMNKFLSSQNDSICGVKCIKMDHGGTWRGYVTIGTAGEDLTSYHCGSSFSFGSCDSGGNGDSPGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RGT7</accession>
    <name>A0A6A6RGT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BU16DRAFT_498897</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2502970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1205"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1600"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1627"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1655"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="1"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="959"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="23">
        <location>
            <begin position="1800"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="592"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2502970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1858" mass="206564" checksum="4E77E5C1AA7AEF82" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RH68</accession>
    <name>A0A6A6RH68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_588647</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004181">
        <property type="protein sequence ID" value="KAF2503110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RH68"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2503110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="315" mass="34190" checksum="9D6128DC1E920400" modified="2020-06-17" version="1">MAAQQDKSFMGMPGFVVDFLMGGISAAVSKTAAAPIERVKLLIQNQDEMLKSGRLDRKYDGIVECFRRTTQQEGVVSLWRGNTANVIRYFPTQALNFAFRDTYKSMFAYKKERDGYAKWMMGNLASGGAAGATSLLFVYSLDYARTRLANDAKNAKKGGDRQFNGLVDVYKKTLASDGIAGLYRGFMPSVLGIVVYRGLYFGMYDSLKPVVLVGPLEGNFLASFLLGWSVTTGAGIASYPLDTIRRRMMMTSGEAVKYKSSLDAGRQIIAAEGVKSLFKGAGANILRGVAGAGVLSIYDQAQLIMFGKKFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7K6</accession>
    <name>A0A6A6Q7K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_532219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7K6"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="217" mass="23485" checksum="940BFEEA0926AACD" modified="2020-06-17" version="1">MPTPTTIPARHGAHALLHPGQSIRITSPSGHQVVDLWAFPLAVSTPSFLSMAQSRSRLSSIRPKVNDTFVDARRRAVLTMIEDSSSGVHDMLFPPCDKWRYEEAGAEGHGSCAANLRTELAAFTAKLRLQGELGSPLMELEEKIGEWGWTPEPLNLFMNVPVGGDGGLSVKRPACTEGNYVVLRAETECLVVMSACPNDLLDTNGGMPGDAEFEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8F0</accession>
    <name>A0A6A6Q8F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_224827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8F0"/>
    <dbReference type="OrthoDB" id="5244943at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025386911" description="CBM-cenC domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="3">
        <location>
            <begin position="166"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2488660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="333" mass="34339" checksum="33F2408FDDCDFDD5" modified="2020-06-17" version="1">MLFLLSVAFAQFLLPATALSIAVRATDCDGIASGSVYTVGGASFLVEADAVKSFNNLGDPSFGGSFVDCMTRCATTNGCTDLSFTSGGTCYLKQGVVNGIISTETGTCDAKVVPLASASSVPASTCAAVTVTASAATETTTTTATSTVTVSLATATSSTPASCPTNAFSNPSFEDFTLGYFASWITIPSTYSDHMELKSVGTAAKDGSYVLSVQTVVSNSDHRLLQSVLLCPGTIYKLSFDARRVSPAANTNSIGVSAVTIVGAGLYRQTMFTQEVSSDAWTTFTSEGYVVVPAGSAPVQAGVVIDVNFIADLDSTATKEMWIDNLKLFPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q8U6</accession>
    <name>A0A6A6Q8U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_422499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004203">
        <property type="protein sequence ID" value="KAF2488424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q8U6"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <name>A0A6A6Q8Z3_9PEZI</name>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 269.34</strain>
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        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
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    <reference evidence="1" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2488436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="182" mass="20070" checksum="4E00D1CF1115479E" modified="2020-06-17" version="1">MTAPISTCLSTTPPADPEEHVFRPLVPEEDTFALKLLKAYYEPGVLPLRDDPFKRLPAPDSFHALTHHLSLYILALRHDEAQLADAVYIQIRHYYASTGHTASPFRLEYVYNHTEGPNALRAFLAETAACRLVLCRDKRADAARGVVGPEEALSKSMRALVAKGGDLAVDLMAAVVRLSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q919</accession>
    <name>A0A6A6Q919_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_568108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q919"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2488581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="53" mass="6281" checksum="7B194D094DA9E23F" modified="2020-06-17" version="1">MPSHKSFRTKQKLAKAQKQNRPIPQWIRLRTGNTIRYGDSKHLPTHEDLRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q923</accession>
    <name>A0A6A6Q923_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_218289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q923"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="183" mass="20430" checksum="2E0CC0FA7D1C199D" modified="2020-06-17" version="1">MWTDRLLASLGHGRSTTATPNAAPCSESLRNTPIQPQISTNLDAEAMEANDDVLDFDNSLAEDFSSEAPKTDEIQITNARAETIADSPRQNRTHRADLDAGPDSNPANCAVPIEGGTKHRKRRVVLKFAFLHRTYRKIVDRAKRKLSSSKAQPDVRSPFQNFPSREAYLRWLVAIHRGLLSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAM2</accession>
    <name>A0A6A6QAM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_597911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAM2"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="146"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2489119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="297" mass="32634" checksum="158E0FE82F7EE77A" modified="2020-06-17" version="1">MPRDLESEKATIDGMAPLTTVTKEPEKGAPPAQTFASPDSDDQLQLYRDEGGINALHPYCQALTSNDLESCIHLENATFPPHEACSREKHRTTSFVQLITSNATNLHSLLTCLIYQLDNPYNFQFYSSNPHQFIYRLKSCGELCLGLFTSATSTSKSPTLSALSKKPFAHPADSAYPDRKSILLAHCIATKSENLTVTDNDMAMPPLGHNEHGRTICLHSLAVLPEYQNLGLGRTVVLAFVQRMQSAGMADRVALLAHEQLVTFYERLGFENRGKSKATYGGGGWFDMVVEFGGMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAW5</accession>
    <name>A0A6A6QAW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_544625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAW5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2489219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="481" mass="55429" checksum="46D444BD7B3FA207" modified="2020-06-17" version="1">MNKESYRSYHFLRKHTHFPEITTPSRPQTPDTQLTSTMQGTSSRTYYVHSGLYGMSEGVLHRIDKQSLTPPALPTRKEWLEALDGLPPATNLEASPGTTCAICLDDLNMQEEDEESAILPELPFATHIMGGYPITLPCEHSFHIACAKAHFVGKTTCPLCRRVYYSKKSTITARREAFESRSLFELSGITIGSYLQVEIPVFIEMITGQIYDLVLAFADFSDSRAILANQYCDAGTLIGKMRDMLLEFQYESYPWEWLHRYMEHRVDKHINDLLGPTRRARKARTARAKELRRIKYIVCVASWFGLQMCALKLSFIPLVQCIEVEVAHGHAEWLQRFETLGSEVVWEDDEYLLEGEEREEVFRFEEVEVSSEDEGSASGDDDGQTVHHEYIGPEGEDDEEGEDEGSASRDHAVHHEYTDPHSQPRRFTVFQYEYYNNHYQSFSRQNPQHQLLGGIADELRELEPFYFFDEEDDEEAEDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBF3</accession>
    <name>A0A6A6QBF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_531856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBF3"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2488797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="214" mass="23360" checksum="94F744936D82BA22" modified="2020-06-17" version="1">MAQTQRSNPTISTKVPEEVEACLLKTRFVNLATVNENLPHISLMNYTYIDNSPYHAGPIVAMTSPPQSRKIHILQKNPHVALSAHDWVSMRPLAYGRETAPEPSALTALLLGINSASLSKICVTINGTASLVPAGSEQEKWYKKRHMENNDFAAEQANGLASEEAHAASPDGGKEFYIKAEGVRVIVVKITGGSTVDWQGAEQRWEVRQLTNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBT8</accession>
    <name>A0A6A6QBT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_598602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBT8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025644644" evidence="9">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="37"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="10">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="295"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2489549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="407" mass="44021" checksum="11CE7587BDFF80CB" modified="2020-06-17" version="1">MKSRFSLLSVATGLLPWAEAYVSLPMTKLLNYEKSGYTVSITIGTPPQTVMAAIDTGSSDVFLSSYENPWGYFNPNISTTYTPLISLDPFVSRYGQGNQNGTYLADTISLGVTTEANLTMALIPPPGMGGPPYNLLGLDFDDGEMRPQLAEIAANYTIPESDLPTYPNFVTTLKNQGSIRKRAYSLYLNSLNARFGELLFGAIDTAKFVAPLKYVSMARSPVTGLHDVMMVPWVGLSMRTDKGTVHLPLPMRPNATFDSGTTVSYLPLAAARQIAVETGAVERNVSGAIRYYLPCDAAMNFSLSYTFGHGKTTCASGGPRIEVPASELLLPLGANSDADVPDLPKFGGSKTCTLGIMGEETYTPYVGYLLGDTFMRSAYLVYDLEEKKIGIAQAKLNVTETEIVELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBX5</accession>
    <name>A0A6A6QBX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_531167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QBX5"/>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025553118" description="Extracellular membrane protein CFEM domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="88522" checksum="9417111C32E4A96F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC67</accession>
    <name>A0A6A6QC67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase-like protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_470961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC67"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="361" mass="39358" checksum="9C855A4D3CF7F9DD" modified="2020-06-17" version="1">MVLFLRTELATYRSLQRQYHFLINSSSLGLFAQEEHLPALLGNPSLKLVAIYSRSLASAKSLSKDLKDVDLYSEDSGEGKGYADLLKRDDLKGVIVCLPISNQPTFIKQALSAGKHVLSEKPVAPTLAAAKDLIDWYRASIPPSTIWAVAENFRYLDTFRYGAEQVSKLGRVLGLRVRMGQMVKPGGKWYETAWRKTPDYQGGFLLDGGVHYIAGTRVFLGPANAIVRTSAHTQQLQEHLPPVDTVDATVKLASGATGTVSMSFGTTFKGNEYSVACEKGTVTVLRGKVVVTKDGEEEVKEFPDEGSGVTPESRAWGESIVSGKADPRQSPEEALADLELLEAFLRSGEQNGAPVELKYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC75</accession>
    <name>A0A6A6QC75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_553402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC75"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2489253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33779" checksum="E7BC870AC78C31F5" modified="2020-06-17" version="1">MASAAIHNATPASSKLDQVIEPLAATPATKPAKHNVATELNYYQDPGDGSLPAPIYVGKVDNVDRPHVAVSTTIHDISGDEEKYTLDGNGFQYVKHSSAEKDFRDDAKIIADYYPEVEQLLKDSTGATRVFIFDHTIRRAPTDNRAGGPGEEIKRGPGKRVHIDQSYSAARGRVAHHLPDEAEELLKKRFQIINVWRPIKTITRDPLALADAHTVPDSDLIGAALIYPNRAGETYVVKPNPSHRWYFKFGQRPDEPLFIKCFDSIDDGSVARRVPHTAFEDSEFNGEAPRESIEVRTLVFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QC86</accession>
    <name>A0A6A6QC86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_471469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2490005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QC86"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF101">
        <property type="entry name" value="HYPOTHETICAL ASPARTYL PROTEASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="33"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="497" mass="53171" checksum="5F2B368D00C4A747" modified="2020-06-17" version="1" fragment="single">MSFLRRTETAKTIPAPYVFPPSGTFDGNDGSWSTFMISVGDAQADGHSGQNFKVHISTGGSVVTIPAQADWCNEPDKDSCAEGRGIQTFDAKQSLGFASSSSGSWQEIGIYNLPLPAAVELYPDLRPNATYGHDTVGLGADSTLSPMLTGQLVAQIITEDFFMGVFGLSNTPLGIGGGPIDTFLSDFQNANQTPSLAYGYQAGAKYREWPRNTAGVLGSLTLGGYDQSRFSGHGISVPMPPGNSSLIVGVQSITVAPDPNIESNVYSMTAGTSGFLATIDSTLPYLWLPDAICDAIADRFRLTYDNNTNLYTVNDTSHSYNYNQNATMTFTIGSGPNPSNNVASIVLPYAALDLTASFPIYDDATKYFPLKRSPTGIFVLGRALLQETYLIVNYEKKNFTVAPANFTNPMPESHIVTIYPASYVPPSTTKKSGLSTGAKAGIGAGCGVLGLILIGLAIWFFIRRRRNRNKPAAPPPPSEIDTLVAGTEVKKRRISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCE3</accession>
    <name>A0A6A6QCE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_544059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCE3"/>
    <dbReference type="OrthoDB" id="10518503at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="483" mass="51853" checksum="D7DAF0D449C103ED" modified="2020-06-17" version="1">MWPPRPALPSYASSSANLAHLAAERPTSELETQLEADSVDSEPPARPALVPYTSSSPSLTNAIPAVVEPITNQPATQPVSDSNPTVPSARARRWASSSDGTCDFMVAAGGTPDQPLSTPIAIRDEPLDPSTIKPTQPSPEALEPRVPIPRVSPPRIAILASSDPPTATPTPLEPLAPTKATAPTSINAAPDTSTRETPTPPAPPIPSSLQALWTTLTGDQRIRLITAWLEMAPTPQQRGIFRALLTNHMDQTTQLSFAYMTVASIEALDTTTVPFPQLPPQPHPGTPFYPQSPDLVDTTMLDVFTTSPSATATATATSDTTSTIPLGTRPYRSRSRSRSHPPYPLLSPTAPSQRYARSHPQSPPWKAYRVLGIYPSRSPFEPLRSARAELREEPEGGGYFDGGTSSTGLDLKDEAGASGVRQRKVRAEEVVDSPSRQIYEEVAAVAKAGDQNASPRKEEEWSSPGPMISLKWGEVVWGGLVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCW6</accession>
    <name>A0A6A6QCW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_518609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCW6"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2489929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="392" mass="43705" checksum="28E93370424C4C5D" modified="2020-06-17" version="1">MPPPSGQVSNFIDPPTLLPAAIVASTVILTITTVFVAARFTAKTFVLRKHYLEDYLCYAAWAGVVTYTGLFLWNEDYGWGRHMWDVTPSMLKQVMYHLHIMYCIYSPVTLAAKLSVLFQIKRMFTTWEKNMVYWVVMGSIIANSVFYTGLFFSYVFQCWPRAAIWDPSVKGKCVSAIASNLVSGVLNVVSDVEALALPAWAIWHLNMPVKRKVLVFAVFGVGSIACIIGVVGIYFRVILLKKPDFTWICSKAAMLVISEMAVVVIVGCCPCIPALLRYCRGVGRPSPKSTEPSSDPASTPRRYSNSKALNSLAKYMSPGPIGMSKLDSSYSDENLELRQYSASIQKDRNLSEEAMGRGKVGIERFHSTRSEIVRTTRIEQSVEKKGIRLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCX9</accession>
    <name>A0A6A6QCX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_598584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCX9"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2489523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="621" mass="67807" checksum="A78F23C49F008F7C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDL0</accession>
    <name>A0A6A6QDL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BU16DRAFT_154577</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDL0"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019914">
        <property type="entry name" value="Pyrimidine_monooxygenase_RutA"/>
    </dbReference>
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        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03612">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="359" mass="38950" checksum="889B66F70930B5FE" modified="2020-06-17" version="1">MEIGVFIPIGNNGWLISTAAPQYKPSFELNKAIVLKAEKYNLDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSKIKLFASTAILTLPPALVARMATTIDSIAPGRFGINIVTGWQEAEYSQMGIWPGNAYFGYRYDYATEYVQVMKELWASGVSDFKGKHFTMTDCKMSPRPVHPISIVAAGQSGRGLEFASENADFNFVMGQGINTPTKVRDGTEKLVEASEKAGKDCGAYVLFMVIADESDEKAQATWQGYREGADVDALAWMADQGKKDEKADGSSTAKTISLPEGAVNFNMGTLVGSYETVAGMLDEAAEMPGTKGIMLTFDDFLVGMDKFGEKIQPLMKCRAKVAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE90</accession>
    <name>A0A6A6QE90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored cell wall organization protein Ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_530349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE90"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025545360" description="GPI-anchored cell wall organization protein Ecm33" evidence="6">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="41066" checksum="000A15ACDE3BA399" modified="2020-06-17" version="1">MSLLTRFVLPALAAAGTAVAASCSASATTIQNQGDATALAACKTFTGNVVIATGTTDQINIPTVQKIDGDFTVTNVSLITSIGADSLTEITGKFTLNEVQVLTSLNFPRLAAVDDIEWNALPNLQQLTFTTTVTKASTINIQNTELNSLEGIDLETVDTFYIANNRYLNDITLQLTQVGNALTLEANNPAVNVSFPNMIWANNMTFRNCSSISIPSLESINGSLGFYGNDIESFIGANLTTVGKDLSFVSNTKLANISLPLLKSVGGGFTVANNTDLGQVDGFTALQKVVGAVDFNGNFSDVALPGLKDVQGAFNIQSTGDLTKQCAHFSDLKDSSVIKGDYVCEGKVSNPGGAGTTPTSTAGGAKASKTGAAGRVEISSAVMGVSGLIAAFFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QES3</accession>
    <name>A0A6A6QES3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_543925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QES3"/>
    <dbReference type="OrthoDB" id="10550492at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="100" mass="10777" checksum="41FADC7FF120A997" modified="2020-06-17" version="1">MTTDFLRPRSTEVASATPTSTPGASPGKSGLNRNIAIVVFAVLLTTVIVVVLCIHRRRLKKAEADIERGYEDESGFHSIPLHWLQGPGVNRTPSSPTPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QET9</accession>
    <name>A0A6A6QET9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_542995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QET9"/>
    <dbReference type="OrthoDB" id="5140048at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="324" mass="37479" checksum="1EFA0ED11319BE52" modified="2020-06-17" version="1">MAKGKGLFAAIGAGTAISAIAGTYKLSEFLVRAKKLHEVGRENEVFMRLVRRVNEDLGETRRLVKLEEVEYALSTAPEKVAWINSVMKSTRGALERMMPLVEPVAADTEGGHHVGLRHRMKWVLDTKERLVNHNLELVACHNSLTQVLGFLAAMEPLACCEAEKQKQKQQPQQQPLQQQQQQPQQQQRTVTRQIDVEFDGKRGGHKDLQFERRHQGPPREIRYQAEVRREGPQGPPQDFQYQADIRRGGPPQDFGPPQDFRYEREVRREGGRPEFQYRAEVRRNGGGGQEEWIEQREVRRDQKDYYTPDPRDVPRMTTWPRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEZ2</accession>
    <name>A0A6A6QEZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ heat shock family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_531065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEZ2"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2490580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="376" mass="40137" checksum="10E8FCF2D2990D72" modified="2020-06-17" version="1">MVKETKLYDQLGISSSAGQDEIKKAYRKAALKWHPDKNKDNPAASEKFKEVSQAYEILSDPEKRKTYDQFGLEFLLRGGNVPPEPSSGGSGGFDGSGFSGFPGAGGMPGGGGGGTRTFHFSTGGGGGGPGGFHFSNPESIFSEFLRGGGAGMHEEDDFGGFGGGFGSMPGVPPMSGSARAARGTKGSRFDGGRRAPTPEVTVVEKPLPVSLEELFSGTTKKMKIKRKTYDQATGKQSTQDRILEVPIKKGLKAGSKIKFSDVGDQVEGGTQDLHFIVQEKAHPLFTREGDDIKNIVDIDLKEALTGWKRTVQTIDGKQLSVSSAGPTPPTYEDRFPNLGMPKSKKPTERGDFVIGVRIKFPTSLTQQQKEALKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF00</accession>
    <name>A0A6A6QF00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_469590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF00"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="137"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="249"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2490689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="348" mass="38886" checksum="38A7DFE6C69F815C" modified="2020-06-17" version="1">MPDGSDNSRNPRLQTYFSWNIEDVKWWTKHYRTEIAASTASVLATGVTYPLDSTKTRMQVHKYDSILDCIRKTYLQERLAGFWRGAFAPLVSITVVRTVSFSVYQRSKYLYDGWMHRSTGVSPLMIANTKGATPNLATVICFGAAGATAGVATTAIACPFELIKLSAQTSYINAQKKTSSSLDEPLKRSYQNLNTLETARKVIHDRGFRGLYSGFHLHLLRDSIGTGVYFMAYESAKQYLANARGNSPTTPTAVVIAGGLCGLVSWAVIYPIDTTKSQYQQNCLTSHKDRTVVPKIQYGNQSMYRGLTVSMSRSCILNAIFFSLFEYTKKGINRLEINEELLSRHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF33</accession>
    <name>A0A6A6QF33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_469328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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        <property type="protein sequence ID" value="KAF2491018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF33"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000614">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="293"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="926"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1114"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
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        <location>
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            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1202"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134998" checksum="6BC8CB8B379E0F72" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFE2</accession>
    <name>A0A6A6QFE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF974-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_565824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2011986at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    </dbReference>
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        <property type="entry name" value="TRAPPC13_M"/>
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    </dbReference>
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        <property type="entry name" value="UPF0662"/>
    </dbReference>
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        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
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    </dbReference>
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        <property type="entry name" value="TRAPPC13_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="680"/>
        </location>
    </feature>
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            <begin position="685"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490891.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="90758" checksum="669B7B671B4557DD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFK1</accession>
    <name>A0A6A6QFK1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_142328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFK1"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2491052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="258" mass="28561" checksum="4416F46CCF1DE644" modified="2020-06-17" version="1">MANETEAAPDACPVDPTTREAWLAQAKKAGQQAPHPHPAATAPSPSPSPLVAQSCDSSEIDKSPAQSQSYVSRLWSGLGTDREVSTIPRTVPDQAATKLANNEQETGADKKSGNWIYPSEQMFFNAMKRKNFDPEATDMKSIVPIHNAVNERAWGEIKDWEKGRGADACGGPRLESFSGLSSALTPKARINTWMGYQPPFDRHDWVVDRCGKKIEYVIDFYAGKDENQGRALNFYLDVRPKLNSFEGWKMRALKTFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGK4</accession>
    <name>A0A6A6QGK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_469810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGK4"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="128" mass="14131" checksum="7DDF74FA0EDD61A4" modified="2020-06-17" version="1" fragment="single">WGPPAKGPLRTTKATLQQHLAGVSVSSLPKTFRDAVAITRSMELCYLWVDSLCIVQDNKDDWPTEAPRMGSLYSRAHLVIAASGARDSSEGCFLERVAPSSSIEIPYKREGDRDGGHVPPCTKRRYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH83</accession>
    <name>A0A6A6QH83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_584659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH83"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2491360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="379" mass="43095" checksum="DF292939BC302F78" modified="2020-06-17" version="1">MASVRPSLQLLKPPFFRSNYGPRGLLRVDFFTPKSAGRTATGERPSKADTLTIAEKDALTKQESGITEQSPMRLRMEAFIKQYQKEIVAALEKVDGKPFLVDSWDRPEGGGGISCVLQDGNVFEKAGVNISVVYGRLPRAAIAKMRVNHKALDPDVDSLEFFAAGLSMVLHPSNPMAPTVHLNYRYFETADEAGNSNAWWYGGGCDLTPCYLFDEDAIHFHNTIKAACDKHDKAYYPRFKKWCDEYFSNTHRGETRGVGGIFFDDLDETEKDQEQLFAFVQDCLGAFLPSYIPIINRRKDMPFTEHEKQWQQLRRGRYVEFNLVHDRGTAFGLNAPGARVESILMSLPLTARWQYMHSPVQGTREERLLDVLKRPKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI21</accession>
    <name>A0A6A6QI21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_621187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI21"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35292" checksum="4B4B6694CA45EE82" modified="2020-06-17" version="1">MANNASSDSNANSANNTTMTNPKALKGLMALPRELRDKILFHALPDAYALPISRDPADTRKVTPVGLYPKAPYPLNTSSEHTYRPIPLLAISRQLRAESLSTLSRQTPLEVCNLGAFSAILDTPKNPDGTPLRNFHLSIFSAASDCARARLVPSRFHSSHPCLMHSLLWLDADEMGMTFFDHWLALLERLPRNTDTVTLDFSHPAEWANRRCVLQPVLAFVQRGSAKLWRRTKGRVTVNVVGWGQTDEEDSTTVLERAIVCPGRKKEKREKEKEDLGGGGQNYWSVLSNLEVEGEDTTHLTYPDTSARVTYVLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIG9</accession>
    <name>A0A6A6QIG9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">BU16DRAFT_529398</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
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    </dbReference>
    <dbReference type="Pfam" id="PF04081">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21437" checksum="548830C7D1E89AFE" modified="2020-06-17" version="1">MPPKRSTGPKASAAQSTLAFHGTTNRVTKPTTFPRSAKSHDKIDDILHASKPDPATTDIAPAEEEAAIIPPPALAEPTAPVKPAKQLDAEAAARKVSEARIKKYWAAKEKARLAPRAHQEELGLHEKVLREWDMCGVYGPAIGNSRLKRWNRANRLNLHPPIEVLAVLLMEQDEGNAGAQRAHVDELMTSRFVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ11</accession>
    <name>A0A6A6QJ11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_564471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ11"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="194" mass="21305" checksum="AA273EB1C0A7598D" modified="2020-06-17" version="1">MLPSVRYKLKQTPAIFLSIRASHGTGIDDLAGTQTRSLGLTLQHKAIFRRPLPVAPPQQPDTGAVSKGGDRERRQTAIAMCAGVQHSRYASMCLAWWEQFTAASSHRVVRRWCHYCRFCYTVTATCSTPIKSRRLLLTGLRLFSKDKRNILPLLAHPPASRPLVEPAYGGKGSSSQFHPSFAVGVALSGSDTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJM6</accession>
    <name>A0A6A6QJM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RecF/RecN/SMC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_87276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="431497at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2492648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="38033" checksum="FEF85BF3495C9756" modified="2020-06-17" version="1">MHIHQINIHGFKSYANQTHIEPFSPKHNVIVGRNGSGKSNFFSAIRFVLGDDYNHLSQKERSKLLHEGSGSAVMTAYVEVVFDNSDNRFPTGNDKLTLRRSIGNKKDEYSIDHKNSTKKDVESMLEVAGFSRANPYYIVKQGMVTELTNKSDQARLELLKDVAGTKVYDERRRESLRIMQETDNKRNKIDELLNGIEGRLQELEQEKEALTVYQNKDRERRALQYTIENRELIKNQKKLDALENSRQERRDLEEEHDAEYRQREEELDALDMAIQENRQRIELLNAEKLQDKSEWEEYMKQKGTLESDVAEIAEGQDREERKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QK86</accession>
    <name>A0A6A6QK86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_564970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492519.1"/>
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        <source>
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    </evidence>
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            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
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</entry>
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    <name>A0A6A6QKV6_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bills G."/>
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                <person name="Lutzoni F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2492955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="342" mass="37160" checksum="C95F4B364623B2D4" modified="2020-06-17" version="1">MSSSSPPSPLPTLFITGALGYIGGTFLTVLKRSQPSILTRALVRDQTQAETLSDFYGWTVTPIIGKLDDLEFLTDEAAKADIIIQATGDNTDAVLALMEGTTLNPKHNSANTIERPIFIQISGASNVAHTVLGEKSPRVWSDIADWDDLLKLEETRISVKTDNAIRKLSSKKNIRSLTLSPNVLLGRGLGAGKTETFPKLQYENVLKNGAAFLGGKGTNVWSSMSIEDLGRACVFLLEEAQKGNKSRLQFGQNGYYFITAFDLSAADRAQALGERLYKQGLIPTPEVQVKTLEEIGAQFGPFGPVLAASSSLIRADKLGKLGWKPVDYDWVRLVQEAPGTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLH1</accession>
    <name>A0A6A6QLH1_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLH1"/>
    <dbReference type="OrthoDB" id="10590748at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="281" mass="29275" checksum="77E99DA68344B88A" modified="2020-06-17" version="1">MSTSMPFRGRWTIAGPSRGVASNESQPRTIVQAFQCSIHILLRAPSEGDAGDIASGLASRTSSHGGLSCTLTHASSVSVPVPDDNFNPTVGQFGLMLLTVLHHAGRVFDAGADSCSSVLSWTLPPAVSPPGGGMPKIHGLPCFHSQSSLASLSGRRTVHSPPGAGHPDPDSTPSTTWTAECFSTRRQSPQLPACCRPAAGSRRLTTDLALAAHPGIATPASRASSQVPSSSRTRQSACSSIPHLRPACRSSKHINSCDRRVPSHGGAVEYLAMPRGSSRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLL6</accession>
    <name>A0A6A6QLL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dicarboxylic amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_95711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLL6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="61"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="576" mass="63664" checksum="68D8F569F48D54A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMI8</accession>
    <name>A0A6A6QMI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_582791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMI8"/>
    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="289"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="39166" checksum="C2140A9AC7151864" modified="2020-06-17" version="1">MTILPRCRVVGVDDRSGLEGRDRPEKVVTRAQRVDGGGRPWLGGVLRYRKKPTPSGSTHFTRVAHHSGRQPQRRCGRQTVALENSAACRGRQQGAVEGLTLALSPLRAIFPTAGLWRGGPSFDVRPRLYSAGHTQTRPLLLRYCASTLSRRPWEVPRPVLRPDPSAAASQCSAVANVRPHCCSARAVWLTARGIKGARHGVDDTRGQRARALSQPSGSTFGTKRVQSHRARTGHSTDQGPRCGRGMVDQEIEGQRHAERSDSGRKPPAMRKHEGDAARPLRLQRRASLATRPDRRCLEAAGDTGGRVNLSASFITLPWIARQVEPHGESIRAVIARAISLRCQTLHGPKDGLIHCCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMX6</accession>
    <name>A0A6A6QMX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_465013</name>
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    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QMX6"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134035" checksum="2730ACA12719E009" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPD8</accession>
    <name>A0A6A6QPD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_528166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPD8"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="218" mass="24122" checksum="369F4B97E6A303F3" modified="2020-06-17" version="1">MRFRTGAILIGALAALISLYSVLEARLSDFYIFDSPSLHALAREAITNHGNDTAAMVRYIVDDLSQKHPKNINLEEEWVFNNAGGAMGAMYILHASVTEYVIIFGTAVGTEGHSGRHPVDNFFHILTGTQTAYTPGPGSFLPEVYPPGSMHYMPRGTVQQYKMDSTCFALEYSRGWIPPMLFFGLADMVTSTLDFQNIWRTGLITAREMGRNLGAGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR80</accession>
    <name>A0A6A6QR80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_45155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR80"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="228" mass="25545" checksum="1A319DB92903FCAA" modified="2020-06-17" version="1">MPPALSDEEASVSGNEDEIPFDKDESDVQNGNENGEEDGDENGSDEVGEEEYIVEAILNHAFDDEVLKYEVKWLGYEKKSDRTWEPEDNLTGATDLLAAYHKKIGGRPKLGEPTSASGRKRKQSGTPVASKTPKQGRRKSKGGKNGDDSTPALKSKIKSEQVWEPPQGLWEELVISVESVEQTTDAKTGGPKLMGYIMWNDERKTQHTLSLLYKKCPQKMLQYYERHL</sequence>
</entry>
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                <person name="Bloem J."/>
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
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        <text evidence="1">Belongs to the UPF0507 family.</text>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="VPS9"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="340"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="263"/>
        </location>
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            <begin position="563"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1318"/>
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    </feature>
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        <location>
            <begin position="166"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
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            <end position="574"/>
        </location>
    </feature>
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        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147643" checksum="63F8CE828693900E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUM7</accession>
    <name>A0A6A6QUM7_9PEZI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_539898</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2494627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="451" mass="50844" checksum="54BC16611DEF8848" modified="2020-06-17" version="1">MAIPKRSSRWYRIKWFTHEDTAEERKLILKLDLLIVPYAFLSYWVKYIDQANINNAYVGGLKEDLGFQGNQLVHLQTLYTLGAVLGQLPFLFLFPKIPMYLLIPSLDVIWGVFTLLQYRANSYAELAAYRFLVGWFEAAFFPAMHFIFGSWYRGDEIARRGGVFYVGLTLGTMTAGFIQAGASAKLNGLHGLAGWRWMYIICAIITIPIGLLGLVVLPGTPDKPNRLILTHNDIELASARLERAGHVLTGKVTWVTVVKLARSPRIWALLLLDVFFWNGSINTSTGGYLLWLKSLKRYSKSRLNELGTASPGLGIFYTLLVCFSSDLLLGPAWAITLAHTWNIIGLVILTIWDVPETAKWFAFMTTYSAVAMSSVLYGWINSQLKYSPAERSFTLLLSNALAQSTTAWTPLLTFKTVEAPRFKKGYPFVLANAVCLIVLAHLISWYIERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV34</accession>
    <name>A0A6A6QV34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_365093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV34"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2496046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="171" mass="19137" checksum="675B9438CA2519F3" modified="2020-06-17" version="1">MGIAPMRLPSFTPLLPSFISTSSPALVVRPVLRPLPSYCGLLVMGIGAICVWKQASGLRAGICWQGQPSQGLYAIVMSLYTSSLIGARARTRLPVLSRAQKRFLPHLPQHWNPDTSLPQYLRKDWEVLTEREISSNSPGGINGKLSTDALDRKWFSTQNAYFSINVWRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVC2</accession>
    <name>A0A6A6QVC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_560958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVC2"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="374" mass="40771" checksum="08AEBCCFA2A02FB8" modified="2020-06-17" version="1">MSSSSQVAESWISSFCGLLGHEYFAEVSEDFIEDDFNLTGLQSQVPMYKEALEMILDVEPEDDDDEDEEEDEEDEDEDILGDDKPTGYRRASDRRHLRMASDLSVIESSAELLYGLIHQRYITSRPGIQQMAEKYELQHFGTCPRVFCNLCKVLPVGCSDTPGSETVKLFCPSCLDVYTPPNSRFQTVDGAFFGTTFGCLFFMTFPELEIGTVRQSAAGAADALLAIQAAQKASGVTGTSLNPLPLTINGINPSNMAPGLGPGNIYEPRIYGFRVSERAKSGPRMKWLRMRPVDITELDETRRFWDGREGQGSEMGDDDLNMADAAPGQAVDRRKKLVGRRRRTNGSGGTGAVGGAVGEGGSPMDTNGVGIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVF1</accession>
    <name>A0A6A6QVF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_376919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVF1"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="364" mass="40653" checksum="E1C6CDF1FB93A1B7" modified="2020-06-17" version="1">MADTLKESPLRTVQVEALVVMKIIKASAGAFPTTATGSLVGMDVNGTLQITNSFPFPTVDVPATDGHQDSASNLAAAAPRAKANTAYQNEMIKFLREVNVDANNVGWYTSTNMGNFINLNTIENQFFYQKEMNERTVALVHDVSRSSQGSLSFRAFRLSPSFMAAYKESKFTTEALQKSGLRYQDILIELPLTIHNSHLLTSLLHQLPSEAPKEELAFPPTLAALQTDPNTPQPPLYPNFDSLDLSIDPFLEKTCDLLLESIENHHTELNNHQYYQRSLGREQAKITAWQQKRKAENAARVAAKQTPLPEDEWQRLFKLPQEPSRLEVLLNSRQVEQYARQVDGFTASVSAKMFAVKSNLLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVH9</accession>
    <name>A0A6A6QVH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_526684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVH9"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="316" mass="35299" checksum="140D164C675FBA39" modified="2020-06-17" version="1">MVGKHGGTDDFQLYRYKPSLPAAVIFIVLFAVTTFFHVFQCWKHRSLFMIALIVGGTFEFVGYAGRAVSAHNTQSLNPYIIQTILILLGPSLFAATIYMILGRLIRRVDGEKYSPIRATWLTKIFVLGDVLSFLLQGGGAGIMSGANKGDAKNAQSKIDLGQKVIIVGLVLQVLFFGTFGIVAGVFHMRARKVAHIQALTVPWERCMHVLYATSVLIFIRSIFRVIEYAQGNKGYLISHEIFLYIFDSMLMLGVMVILNVSHPGELLDQRKRENPHHLLEERDVSRDPPAYQGNDTGYPPASNMPYVEGPKATTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVQ9</accession>
    <name>A0A6A6QVQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_527901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVQ9"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="453" mass="49938" checksum="68FD36F305B8D9C7" modified="2020-06-17" version="1">MNSMIRGAVTSRRFVFAAVTVILLVLFFNAIPSGYGYLDPKPEVPNQGTAPPKPPPKNAESSPSPLPSLASSASSPLAQPSTPAGTPQPSNQAAASPSTHPSSSTSPTSPSSTPSAKKPDNELTKTAILASLQKEDTTWLAAFHPEVHAAIYVVDNTTAPYHVPANKGHEGMVYLTYLIDHYNSLPDVMVFLHAHRYAWHNPDLLGSDAAEIIDKISAPYVQRMGYVNVRCHWDPGCPAWMHPLAPETERTDVFKPEEVELAGAFREIFPGEEVPEILAQPCCAQFALSGDAARKISLERYTAVRQWLLDTKLDDAISGRIWEYLWQYLFTGQPIACPRMDLCYCDGFGVCFGGEKGKNGEQGMNEYWDLRNEKGKLQAALGQIVDEKEDEDGKKTKPVLTDAEKHIVKDLEAQIKDFEDQLNEKLKKAKKRGTDPKLRAEDCGRDWKEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVZ8</accession>
    <name>A0A6A6QVZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_561150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVZ8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="241" mass="25628" checksum="929BF8631A886223" modified="2020-06-17" version="1">MSVDWWYSAILELAKTAQTSVESSAIFDGSDTSMSGNGAYVAGQGDVVLGGNGLPEIDLPHGSGGGCKPVSLGLTDGTTVSNGDGLSYNPRCLKRDLTTAINQKYANATAVVNQILKPKDVYDFQMTMQGYPGSGNIGVHGGGHYTIKGDPGRDLFVSPGDDVFYLHYGMIDRTWWIWQTLDVRKRTGAQGISGTGTFLDSPPSANTTLDTVIDLGYAAGPQVTMRDLMSTTSGPFCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW31</accession>
    <name>A0A6A6QW31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW31"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="435" mass="48742" checksum="8A2CB872A251B259" modified="2020-06-17" version="1">MATITDLPSELLIDTFAYLDRLDLKAVRGVCRRFAEISTPSIFQRVLVAPRYQALGAFQTIFQHAVYHKYVKEIVYDGSVYDAGLATNEQVYMAHLSRAECDAYRLDSWGRRKRFKQYQQLYHDQEGIQDSLILFRTLERGLESLPNVTTITYSPGPRNVPIEKKEAKDILPRGEPHSTPSFGGSEGIVQQCSHRGFHYLIGALALVKYSGIRTFRVEAADRPSEPQGTIFTSYAFELPDQAQLQAGLHLFSTLHNLDLPLSLAILGTSSSIPSHLTALRGLLRGAKELRTLSLHLHKWHPSPQSWAPNTSAVSLVLGKTTTWPHLRFLSLGGVHASAQELVDLALRHASTLREVRYSRCSLIEGKWSDVVDSILRTTHIDSFEISKVHEAVVGSRIFAHLSEAEMREFTYSGQLQVGAGGERYYVPSPGHRSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWE5</accession>
    <name>A0A6A6QWE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_537922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWE5"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF87">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025553636" evidence="1">
        <location>
            <begin position="22"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="116"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="395" mass="43299" checksum="54EC3444B6C50733" modified="2020-06-17" version="1">MAAFLAVAILAAISHSNPTNANSVSFAAEYRHPPNGVCVDYTVKQEITSTNYIWALEKFKSNFDTIDFITDIARKDSKTAFHPVRSNTKNETKTYEVSATFCSPKKATAGKVNTVLLATHGLGYDRRYWASSWKPEDYSFADFALDKGYSVFFYDRLGVGKSETVSGYENQGSIQVALLERLVELVRAGRYTGAIGKPKNIVLVGHSFGSFMSAALINDQPKLVDGVVLTGIAYPNATDLAGPDSAWSLETFAARIARFQDKKWSKLDTGYLNFADIYSHVNGFFKAPNYDMPTVEYAQAIAQPFAALEFVSLQLFKLDSPTFRGPVMVTAGENDLLLCGGECKSTFSSGVAEQAFKGAKDLNLYVHPGAGHGVNFGFNATVFYGKITEFLDKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWH9</accession>
    <name>A0A6A6QWH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_580851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWH9"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="143"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="635" mass="70861" checksum="773BA4D822C556ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWR0</accession>
    <name>A0A6A6QWR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_537709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWR0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2496534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="266" mass="28407" checksum="13CD18D248A60725" modified="2020-06-17" version="1">MSSSKVVLVTGGNGGIGYETVKALLQSDKPHHVIMGSRSLEKAKLAIEELKKECPESTNVVEAVQLDLTSDESIEKAFEQVKTSPGRLDTLVNNAGATFDLEFLAGKTSVRDCFNRAYDVNVAGTQVMTYTFMPLLLASADPRLIFVAGLSQLIAASEGRYLYSPPQPVGWPKKTAFETIGYRCSKTALNMLMLDWNYKLKGDGVKVWGVGPGMLATNLGGMGPEKAREMGAQPASLGGAVLKSVVEGERDADVGKIVGKDGLVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWZ1</accession>
    <name>A0A6A6QWZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_507265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWZ1"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="233"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2496672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="544" mass="61080" checksum="71A95761F9EC369E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXT3</accession>
    <name>A0A6A6QXT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_484528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXT3"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11030">
        <property type="entry name" value="CYP105-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="404" mass="44364" checksum="A1D0CD6C3ED088D5" modified="2020-06-17" version="1">MAAISSPPKFPFARPAAAEPPAESARLRATEPVSRVELWDGSHPWLVVKHQDACSVLTDQRLSKERTRPGFPEMSAGGKAAAKNKPTFVDMDPPQHMQQRGMVAPIFTKERVENLRPHIQATVDRILDAMVAAGGETPVDLVEKLALPVPSYIIYGILGVPFEDLAYLTEQNAIRSNGSATATEASSANKELLDYIGKLVDQRSSEPKEDLISKLVVEQVKPGHIDKSDAVQMAFLMLVAGNATMVNMINLGVVTLLQHPDQLADLKTDPGLAQVFVEELCRFHTGSAMATRRVAKVDIMLGGKLIKAGEGIIASNQSANRDEDVFPNPDVFDMHRKRGDEEALGYGWGEHRCVAEWLARAELEIVFATLFKRLPNLRLAIPFEEIKYSSPTKDVGITELPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXV2</accession>
    <name>A0A6A6QXV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_354720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXV2"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="100" mass="11690" checksum="38EEE7539BA2B34D" modified="2020-06-17" version="1">MISVLGYFVPKDGKKDYLQEQLHALVPLVKENEPDCVMFEVLYDDDLEQFVIHSMFKDRTALNFHLKQPYLVAAQTGVLSEAFENMDLRIHERIDGFTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY24</accession>
    <name>A0A6A6QY24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BU16DRAFT_458568</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY24"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000037">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025597353" description="alpha-amylase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="35"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="52"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2496974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="499" mass="55014" checksum="B77202CAD35175A3" modified="2020-06-17" version="1">MKQKILAAAAAAVALASVAVDAATPAEWRSKAIYQVLTDRFARTDGSTTATCDTSKGMYCGGTYQGIINHLDYIQNMGFSAIWISPITYNIPDTTKYGQAFHGYWQQNLYELNSNFGSGSDLKSLATALHDRGMYLMVDIVVNHNGWKGDASSVDYSDFYPFNKQSYYHSYCAITDYNNQDNVEDCWLGDSNVELVDLKTEDSTVASMYNTWITQLVSNYSIDGLRVDTAKHVDKNFFPDFNSAAGVFITGEVYDGDPSYTCPYQNYMDSVLNYPMYYPLLSAFESTSGSISDLVNQLNTMKSTCKDTTLLGSFSENHDLPRFASYTQDFSLAQNIIAYTILSDGIPIIYAGQEQHYDGGNDPYNREATWLSGYSTTSTLYKHVAKLNQIRNQAIYKDSTYLTYKNWVIYSDTTTIAMRKGYDGKQIITILSNKGADGASYTQAIGTTGWSAGTSVVEVLSCTTTSVDSSGNLQVPMASGLPRVYYPSAQLSGSGICGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYN6</accession>
    <name>A0A6A6QYN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_526253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3233595at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016651">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29040" checksum="568E61283674EFD7" modified="2020-06-17" version="1">MFTPGASFAEYAVAWQHTTFHLPQHVSFAEAATLPLAGMTAAVGLYRYLGLPEPWSSAKPKDDEKRPILVYGAASAVGAFAIQLAALSDLHPIIGIAGRGVVFAEGLIDKSKGDAVIDYRRGDEAVVAGIKDALKTAGCEDIPLRYCFDAISEAGSHEINAAVLDSERGSSKATHVLPVGRFATKGFTYPEGIESSLMMVGDVHGPAKDFGYIWFRYFSRLLEDGKLKTHPYEEKPGGLGGIAAALSDLKEGKASAVKYVFDIGKTEGVERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZF2</accession>
    <name>A0A6A6QZF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_581798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZF2"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="307" mass="33283" checksum="E17EBF52F9684970" modified="2020-06-17" version="1">MGSMPQVEIGEGMATSWNRLVRFIAAEDNKEYTGEPVDAEIDIGAALTASNPVRVRIFTSSTILDPSTRPTATILTIRTLLAPLSRNEVGTIRCIGLNYRNHAKEMHMELPDYPTLFFKPASCLGAPNAPVVIPYQATDGQADYEAELAIVIGKDAKNVRKETAMDYVLGYACSNDVTARTHQFRGAQWGFGKGFDGFAPLGPCVVAARSIPDPGRIELRTFLNGEVMQEGRADDMIFGIAETVAYLSQGTTLEKGTVIMTGTPHGIGISKTPVVYLKDGDDLRVVMSHGLGSLVNKVEYEDKPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0Z5</accession>
    <name>A0A6A6R0Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_328346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0Z5"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2497904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="312" mass="35131" checksum="314C819504706317" modified="2020-06-17" version="1">MRLFLIRHGETVDNVAQLYAGSRDSELTNHGFQQATRLGRHLNVTGHRFSHVFSSHLQRAFRTAELILEAQASTVSTNDERLQVKRLPLLMEQDFGFFEGKKWYQKPPGGAKSGKEAHRDENVNTPGFVDMETKESMAERMDAFLDEHLIPLLDDRPLDDKRSVAIVSHGIILSVLWRRLLARLPPKSVTPSVQVLETSRSFQLEHLGGWSNTGYLELSLQKQPSPPPQNEVKDDSSTSLEVGLAKTDELPEEIPPRVATTRILHEWTTVIETVNGKSHLQGFKRTGGGVGSAKYDAGQKTLDTFFKRRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R186</accession>
    <name>A0A6A6R186_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_288469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R186"/>
    <dbReference type="OrthoDB" id="2305901at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="167" mass="18954" checksum="8F0125CFA81AB7E3" modified="2020-06-17" version="1">MGTAAQHVLALPELLSTILQHVHDDQPLLNCMLVNSLWEYESTTIQWTEVGELPLENVHPERQQYYADKVRKCSVPIVDVEDGANTTLSLVKHRSLVFPRLKSVKVIGNVSGWRLSVWRLPVICDASFDPLFPSTLQNIELELPTMDCFPPLLELIAVREVFCLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R188</accession>
    <name>A0A6A6R188_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_525232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
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        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
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        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
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    </dbReference>
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        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="125"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <begin position="1"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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        </source>
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</entry>
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    <name>A0A6A6R2R4_9PEZI</name>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="175" mass="19341" checksum="BCA898769155DDBE" modified="2020-06-17" version="1">MPCALGGPGVGGFKCRSNSQQARQLMGPSTATCCDDCLERMDDIPDRVRECLSNPEFGNVAIGTAERVKRLNAAVLEDVREEARLKGQGNYPCFWDKTAIDQDEDVKEILKTVSYYHEPNSGGLGRQEIQYGECADCKSRAAVAGNTFEWYRSDFLARKANGTSLANMKRPDYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49812" checksum="ED0BC1A4C8E5E705" modified="2020-06-17" version="1">MGFEFPPALVPAPRPHVFREQDYLIGVRGFLVVQSFLWVFLTTFVPATVANAANSDGPLYQTIIRKTFSVLFWNDALIYSAFIFLSARTVCLPFLKDTSRQTIASSIFRRGLRMWFPTAVAFAIATLIFSQSGVAYMDDFKTRTGNVSIATPRQIPSFLNWFNSMFEVFWVTKNTNLQAANTAFPSQTLWMITTIYEQSFTIYMTMVTIPYTRRSWRVKAFAAFIITAWWVQSWAWYSIAGLLMADAVVNMSFREKARRGIKVTRSFTFPTWPIYGFLILAGYVMEYLWVAWRPDLRSAELKGHTGLYNAGSLNAGFDVNGPQARDDNFLIIIGFFLCVEHFEILQRIFRTSVFQYLGKRSFSFFLIQSIIIYTAGIKLFAEMHFAHNIAFAVSTFLCLVVCVPLVALTTEVFYRLVDYPSTVLAHLVFDWIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R484_9PEZI</name>
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    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_454802</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
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    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <sequence length="854" mass="93758" checksum="9C12F8E83044936B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="468" mass="52638" checksum="6BDB15475142BE5E" modified="2020-06-17" version="1">MDSTPTVSAPALSGTKCASSCSLRIFENPPSSAADVVVVFSQLVELRKLQEDCCERLKAAKLPARILTFAYDAQPPSSMNNGTQGLTSAEAAVVFCQSLSSEREASGRKNDPILFLTTKNSVDSIIPIILGDSLVLGPLAEETDVNSIIYAPIKRSTFGVLRLHASPYTYRQRILETAILTSLQAVIIIALHIYKLYCGSLFDPSWPIWSSLSVIGFVQKALVYTLLGWFALGYVHLATMQFDVNRNDRLQWVFIAVGISVVIPKHWHFATIDLQALALPLAVTITASMVFSAWMHWVWRFISNDKESKMEKKVKMLVRRASNMVPGDPSRFIEYDSVLDNMSNFTFEYWPWDCSERLPHLYLETCGCRAGSNTIENEEVAFTMLLLTHRVWCILFRHGDDSQVDNDFQQLCISRLKRPYRTSVTPARQIKHCFYYQYYSATSRVSPQVCYLLSIGGGASQSKADWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="577"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2499855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="588" mass="61508" checksum="866EE23862C549DF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R530_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF962-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="213" mass="24040" checksum="4F6C6EAFD7EF137E" modified="2020-06-17" version="1">MSLNLEKQLLFYGAYHSNPVNILIHITCVPILLVTFMLLVRHYILHLPKGTRLCISVEATNSPDIPLPAWLSIPYYPLNLGTVAALLYSTLYILMEPVAGTALSLFIIPSTAYSNYLTSTYGATVNYWAMGINVVSWIAQFIGHGKFEGRAPALLDNLVQALFLAPLFVWLEVLFYFGYRPELRRRLDKGVEQEIRKFKQEKEAKANGVNKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R557</accession>
    <name>A0A6A6R557_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_558204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R557"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2499915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="186" mass="21466" checksum="200E4014F37366E7" modified="2020-06-17" version="1">MHGEAKEILARDTLFIAGCMQCMIRHYDQAVKDKLDLMKGFLTTEENGVRNFRSGTLLWEGACAKNHRRPQKIIKAWVEASMDAQWKGRKRYTIISILPEIDWTPPYFKWLSAKSREAFIDCLGVLSKDPVTVWTVECNVPLDCFKDYIGDPEILCKDVMRMSQQHGIQVNITKGCACRFDHYWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5G0</accession>
    <name>A0A6A6R5G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_535917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5G0"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2499584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="308" mass="34053" checksum="ED390474BA77D351" modified="2020-06-17" version="1">MPSLFEAKKATILQQLAVPVDDYNDLSPKGSIDEGIRTLIDEINALDGLVTTSSCAGRISVFLEGRKKNVPTLETLDDNDPSRATPGGKGGGGTWLFVSHDPIDFSKRPSKHSFFSEFGLQSLGSSDVQYHEQGRRYIHLKFEPMILHLLTASFEHAQRVLSAANTAAFRESGAMGFNSVQGETNPMVAIRSAGFSFDSIIGYQDPSGCNVAFIDEDYLRMMVGLANERFQINSDRILRFRDALHSQYSHASANGSAKPQHVKKGYEDPEVRRQRKRQEGLIRQQSLHNAENTDGNHESDADLGGMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5J4</accession>
    <name>A0A6A6R5J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_615203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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</entry>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Lipzen A."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R721"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2500341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="194" mass="21839" checksum="18E5566AFF03A96A" modified="2020-06-17" version="1">MRPFSHLKRRCPSEWTARRLAHAESSQKQNLKTGLTNLPAALAKSMKPFLRHHVINLPQDHNLLFYPSKLHPTEASFELCLTDCPRPRFNSKHQPRFRALASLTGGDVVSEHAIRLLIGPAARRQRLFSRSPTVAGPCKPASFTNHKETRNLRKASSTTRARVHMPPGSISASQMHQAHIPPRPCLYDPGLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7I7</accession>
    <name>A0A6A6R7I7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_478958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7I7"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025710448" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2500521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="329" mass="38628" checksum="C1E9CE6815636E80" modified="2020-06-17" version="1">MRLRSHQRWHLIALTAACSFVGLSQASLGDRLPEFKECVKVCKEANCGDNPTPISLHHRLLLWDCPSECDYTCQHVVTDTRLARDPPYMQPIYQFHGKWPFYRFLGMQEPFSVIFSLFNYLAHDYGISRLRSEVPASYALRKYYLLFGYFGLASWTFSMLFHTRDFAFTEKMDYFGAGASVMYGLYYAPIRIFRLDKRDPVKQSVLRAWTLLCLSLYSAHVLYLSLWSWDYTYNMAANVAVGIVQNLMWSWFSYNQYKKLNRTWAMWPGLIVAWIIMAMSLELLDFPPWWGMVDAHSLWHLGTVGPTIWWYNFLLKDAHEDLQGTRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R8I1</accession>
    <name>A0A6A6R8I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_578089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="564"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2106"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3180"/>
            <end position="3256"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="4250"/>
            <end position="4327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2500063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="5246" mass="578008" checksum="62A57233B9E8AE70" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Bloem J."/>
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                <person name="Castanera R."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="239" mass="25625" checksum="31256845CFDE3204" modified="2020-06-17" version="1">MQSHRWRGHSAAAPARSRTMAGVRPKRARLQALQQPTAPPAPYRVSWSADRGPMVGCGDGSWGGRLEDQERRYAVEGCEMPLARPCTAQRLPVAPPFSPPTWPREPSSIFQVLPAERRPQDPEKGHDARRVYPSEAAPCCSIRPRGPPVRWAALPPPHPHTLTLAVAIAVAVAHVSPTPRATPASASARSARRTPASSSRAVIAAAAGAARCPETLRRTGHLPKSQSTLPIEAAEMASE</sequence>
</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        </location>
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    </evidence>
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        <source>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38094" checksum="6AD5DA758A6BD031" modified="2020-06-17" version="1">MTLPFSPTPSPSPPYLPSLPPELWIRILIYNADLTHLWTACRQVSQSFRAFTEQAFADTHLRHTTIYFHLDKYNLGGSTRRPEVVTAFTRFSPSRLKERVYFTQNQTDPEILQFSIKNISRGGRGKPKETDVAHLRKLLLERWRQQVQDIRPECPNYVIQIGDMVNDTALPGLELHKDTDVEISFEWRSMLTVFFREQERMRRLAESWHSDVAPQMAESRRKVAAGEMTLADQLVWSAKLWAGAEKGFRKAIRRARLREHYRVNEEMVWAIGSMEHLEGPARLLKDVPGGRVGEKWFQSMYLPEYLLMDEWSSLQRIDSKAEMVAMA</sequence>
</entry>
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            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
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            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18663" checksum="4D5F11ABC1B174E3" modified="2020-06-17" version="1">MPPKSRLADRRPSHTRSAGRHRAHNRSATPKHPQAPVSLPVSIVTSASRIRLPFLVQRLSSFRLGCVARRLGPLFLFAVPCPVFRRLTGAAISTCSIRPPAHLACPKKQSWSCFRTVLGGGVGESSVWSAHHTALASAASSAALLVSGLLPKRAAVRLLFLPLLIVRLAVSVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6REU4_9PEZI</name>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3794120at2759"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2503348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="384" mass="43080" checksum="7D9FE5F1D7D30447" modified="2020-06-17" version="1">MSQTPDVRMTVEAPGRDSPSPENQGYLYVTPFHFECGPEKKRLMVHKELMCSTSPYIRGLCEKAKPLRGSSETLAELSDFFEELLKEGNAAGVNTSRVKALIKVWRGQHSVSANTKKDLKELIKVQTNSVYMNTKMRDTKNAPEGVDSNPGIDSIPDRLWLLKAVAVRKVAEALRDALKTIKREESESIARNPLQAMAHDTLVLEDISSQTVQHLIQWLYQGALQDRISVARMCELYTLAHRFRMDTLQEIVMTRIIACIVHEVEISAPELKIEPSTSQTSEQHPTPTPQMSPLYPPLASVLEYVFATPKAPEKLRNLVTETLAWCAKPSDLVAIQNQLSRKMALLLAHAVLERLTDVRTAGVELSLMERLKRADEKTAQEAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RG15</accession>
    <name>A0A6A6RG15_9PEZI</name>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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    </dbReference>
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        <location>
            <position position="466"/>
        </location>
        <ligand>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2503356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="60950" checksum="1DA3DF70419E7C75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q7B2</accession>
    <name>A0A6A6Q7B2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_231173</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU004204">
        <property type="protein sequence ID" value="KAF2488338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6Q7B2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="487" mass="52021" checksum="AD791AE76D7B60AB" modified="2020-06-17" version="1">MSTFKYPIPSGQFIHGEFVKTKGTEKVTLRSAVDDSVIAEELFYANTEDVELAVESAAKAFPEWIGLSPATRGQLLWKYATLIEENAEKLGYLESVLVGKPAFFGGFHEPKSAGDLFRYFAGFCDKHVGEVQPDDQGFLRIVRNEPLGICAAINAFNSPIITFAMKAAPALAAGNVIISKASEFNPFSSLLLGQLAIEAGIPPGVLNILVGAGEAGAALSSHLKIRKISFTGSVATGKKVQVAGTNSNLKRVTLELGGKSPVIVFPDADLGHAAQSGASFMALNGQGCILGTRIYVHEDIAEAYLGALKAMVEHSASTLGSDPHDMTTMSSPLYHPAQHKTVLRFLEQGKKEAETVTGGNSWGEKGLYVEPTIFFKPAKGAEIVSKEIFGPVVVVDTFKTEDEVLLKANDTEYGLGAAVFTKDIDRAIRIANKLEAGTVTVNNQLPFHPTVPFGGYKSSGVGRENGKAVLKEYSQTKSVIIQYSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6Q913</accession>
    <name>A0A6A6Q913_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell polarity protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_600499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1374"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1478"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="849"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="962"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1280"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2488928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1527" mass="166347" checksum="7FBC5DFEC24961ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QB11</accession>
    <name>A0A6A6QB11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_544969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004200">
        <property type="protein sequence ID" value="KAF2488813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QB11"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
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            <end position="274"/>
        </location>
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            <end position="411"/>
        </location>
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            <end position="43"/>
        </location>
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            <end position="132"/>
        </location>
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            <end position="189"/>
        </location>
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            <end position="410"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2488813.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="773" mass="82060" checksum="602DB5E6B0325CCE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBF6</accession>
    <name>A0A6A6QBF6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_622985</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2489481.1"/>
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    </dbReference>
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        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
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            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="71555" checksum="796D87BBCF613F6B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCI8</accession>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 269.34</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="496"/>
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        </location>
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        <location>
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        </location>
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        <location>
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            <end position="1142"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2489726.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128863" checksum="03CBB97350B91C40" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QCW9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_544886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QCW9"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="188" mass="20848" checksum="1378944E6B25E45B" modified="2020-06-17" version="1">MRPSDAALRRPFDSVKQVHKSWTGLGFAAVLAVEFNFRSGDFAHGECCSGMNTMIVSSTVFTDIGPAMKIEFTGSAPEPYSLRVGARISRPAAASIVAAGVTRRRESRIYNRTVCSYIYFREEFGEVLDLKPILGAFGEAMFEENIDEATTKDTRFFDGKAQKLYYSRTVQIDIILTTNDCVEARTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QD43</accession>
    <name>A0A6A6QD43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_149949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QD43"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="296" mass="32710" checksum="68D078E9575AEF68" modified="2020-06-17" version="1">MAVKKRPSGKSKSLSHGRPPVLSGGKEQPHSLTSKATRTLIRTHHRLQKQHATAVKAGEATRASQLEKEIEDNGGLKLYQVASIKGQSAERGGDSSRVLVEWLREDGVLKGAQEKSADDSSKSYAVLEVGALSPTNAIARTPKLHITRIDLNSQDPAIAQQDFMERPLPEDPEDQFDVISLSLVLNYVPEAAARGEMLKRTCSFLRAPSPTAPSQNGLPALFLVLPAPCVNNSRYLTEEYLVLIMSSLGYQLKHKKLSAKLVYYWWSYTGETKSRKVPKKKLKDGLHQNNFCVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDW0</accession>
    <name>A0A6A6QDW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_621959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDW0"/>
    <dbReference type="OrthoDB" id="3794999at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025613955" evidence="1">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="268" mass="30117" checksum="E6BA498505F7EB78" modified="2020-06-17" version="1">MLWHGLLVAILTISASSMSLNFHRYDASTMPFLQDRLIVDSHPSKLGGSAIEYDLGPWGCLYALWAYPIDRPSDHAVHIRTTVPALVTYILGPTWRSHLEEAGGKQLKRPDHNWTQEDEDSLAKRMLRAGGGYLNIRHIGGHIYDLDDLSKHDWAMGIGASQKYVFGWPGDGGVWVLALPLRLREQSKTRDERGAWSDMEESRAMRSGDAITWATFCHGGVYLESLKDVETMEEYCERLKELGARFYADPSESAEAQYASIDSLTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDX5</accession>
    <name>A0A6A6QDX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_566627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDX5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2490618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="116" mass="12664" checksum="E196832AB2611B47" modified="2020-06-17" version="1">METHFHRPGELQSTEAPSPTPTINPGQRFLHDAQYRTVVLVAAAAIAVLLVTIGIVVWVCVCRRRKRKARAVADVERGYKNRTGFNSIPLHWLKGPGGKPASNQIGPHHGSKPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEH6</accession>
    <name>A0A6A6QEH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_575518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
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        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="219"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2490053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="360" mass="40800" checksum="FAA2DA21BA323C79" modified="2020-06-17" version="1">MVNLQIGSKSSSRVFKLRVVFSTIFFTSIAIPSLYQSILELLWDYLKTSTFYQWSTFETIWTVACYTAIESLFLSVFDEEMTVDFKGFRSEKTSNASSPVRTHRNLPRGMRRPSRRKSEALTYIFPLILMDLTMIKKFANVPLSAMLSSGNYDPGLLLQHPEPLTNSTLSTPFLSFGSQRHTTFLLPTLHNFTLSSPLQTHRALPPLAPTSRRLAVELVASFIIYDALFFLFHLVLHALAFLRPFHAPHHSHYAQLQPQITNQLSVFERLGLVLLANFSLNIIGAHVLTRTLFAPVFVWLLVEIHAGMELPWGYEKMLPAGWGGGAAKHARHHVTGKGGFEPFFGLWDALFERVVGMDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF14</accession>
    <name>A0A6A6QF14_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_530384</name>
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    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2490761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="146" mass="16101" checksum="81A2A016005C8E4A" modified="2020-06-17" version="1">MALRQLPPLLNALFPAANAPIHPIAMPLLRRLQQPLFESLRIPISLSSIASIPSLLGDIWESVLRAVPKKKTSHMKKRHRFMAGKGLKDVTALNRCSGCGNIKMANHLCPYCVESIKQYFKRKLRGDTDTAAAMKSDKPTDGGQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFA7</accession>
    <name>A0A6A6QFA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_543035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Nolan M."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3722008at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="219" mass="23342" checksum="E2C49ACBE54594C0" modified="2020-06-17" version="1">MIIPSRTPGPPTPPSPGRNGTPSPSLTTPQKRLDPRNLDENQITNSPPLSPSQTQPPHRPYHPLTYLDTPILRAHLQRLERSPDSQADCYRSVIHAILTHSLPAAEHFAVYQREPRGDVAQTDANAGVAVMQLAARPGGDEGVGGSWDAAEERLGRYCGGTGNGSGRVYGVGCVGLGVKFFVADGGVLEGRSGVLDVRDDVEAVVAMFGEMKRCPLGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFH0</accession>
    <name>A0A6A6QFH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_138309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QFH0"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="108" mass="11329" checksum="52113605896E7B3C" modified="2020-06-17" version="1">MAVPSYEYVPLDAAPLSQTHRTAPHLSPPVVLCCLALYAPRLLAVTAAVSPLTLLLPSLTHPRRATGPAHSRPAASPPSLVPGLLRMAGVLPMRRGHCSERTASTLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QGX6</accession>
    <name>A0A6A6QGX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_542435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QGX6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025401886" evidence="10">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2491294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="504" mass="55562" checksum="FE832F9CE9FC2D2B" modified="2020-06-17" version="1">MGLAFNILLAIFAGTGAFLFGYDSGVMTDVIQSPHFLWFFNTNPNSDIIGAINSTFSGGAVFGSLMGGFTMDRLGRRRTVQIGAAINVIGACLQCGARNLGMILVGRIFAGWAVGLMSMSVPVYQSECAHPKTRGLIVGITQQMIGVGFIVSTWVGYGSSKVPKTSAFSWRFPLGFQAIPGVLLVLGLFFLPESPRWLMEKDRGDEAMRVLRKLHYDGHNDDWIQSEYNEIKLTIDAEKALTAPGWLIMFKVRPWRVRLTHAVLVQVFTQMTGINVIGYYQTVMYENLGITGGRSLLVTGIYNCVGPIGNFIFITTLLDRVGRRRPLLIGTVLITIALVCEAVIGSQVEHATGARRNSLSIAGVFFLFCVTTIFSFSFGPISWVYASEIMPFQIRGRGSAFATGIGNWLVSTIWSQVSPRGLGAIKWKFYFVFAAFNVCVTFPTIFFFFKETTRLSLEEIDLLFGERANGALPENLEGKQVAVPEKSEDTERGVQRKEETDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH08</accession>
    <name>A0A6A6QH08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_118279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH08"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="215"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="425" mass="46086" checksum="4D5C300640F2E91D" modified="2020-06-17" version="1">MASLKINSIRLNETLQSTCTQWGALSTSTGMCRLTLSQEDKDVRDWLVSQCRELGCEVKVDQMGNIFAIRPGTATDKLPIAMGSHLDTQPAGGRYDGILGVQAALEVLRTLYENNIKTHCPIALVDWTNEEGARFPGAMMSSGVWSTKSSAPLETCWDLRDTEGVTMQEALEKISYLGPTPCDYRENSLECHFELHIEQGPILEREGKSVGVVTAVQGMKWFAVRVTGVEGHSGTTPMDSRSDALVTASRLISAVRDAASRTGLGVATVGVIKSDTSSQATIPAGVDFIIDVRCSTDDKVDALGAEIFKSFDAVIVEEKNATSYNITRTWGLPESIFHEICVSAVRRAALGEVAENQIMDIKSRAGHDSAWTSRVVPTSMIFVPSKDGVSHNPNEYTSPEHCALGAQVLLQAVLKYDDYAKTGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH34</accession>
    <name>A0A6A6QH34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_529885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH34"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2491336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="148" mass="16673" checksum="3FAEF3F54D99E04C" modified="2020-06-17" version="1">MINLLIALMVLILVGLCAIGLLFWLRSVRRAKKGSDLPLYNEKSNSKSLNHRRLTITVQEKQNLIDNSSSPPPSPVPEIRITFPDEVDETGKKQSGRVVVVRVGDHSVGLEPLNEDLPPYQKDSSDRFQSLDLDRIGGLKEKDEKRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH96</accession>
    <name>A0A6A6QH96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_468278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QH96"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2491798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="162" mass="16972" checksum="5FDA43D73ECAE35F" modified="2020-06-17" version="1">MADPESYTVTPSPYPARTKTASASINDIPTTATSIYFADKIVLTITQAGRLAHWLHVPLDTESPASEAPLEPSFSDPDDDSADPSSDLLPLSHLTATTVLGGTVPVLDTMGQLLATQIASAIATRDAGERRMVVVGLGLDKGMVDRGREGFVEVVGLVLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHG5</accession>
    <name>A0A6A6QHG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_130852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHG5"/>
    <dbReference type="OrthoDB" id="5335493at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="459" mass="51634" checksum="045A0753E7E56433" modified="2020-06-17" version="1">MAPTRIGIWQAQATLAQTLQQEANILSTVDHQRPSKTDLEKAIEEEVKAFNHETLLHFVNQVTVRPVPSDANSGDDIFELSGPSITKDLRWLEPKRTPNKRWEISIEKIQTIYGWDKRVSMRLLKSSTTHRRSVELRSGAGWVPLHDVLETRPLLNAEISVGGQKGFQLQQEWWYGNGKTFDLLGLPKELRFAIYEQLLCAPAYPYQWLSNGYLPYCEASQLKSGLLSGSEIGSAGTFVRSGNYAHKGGVEMLNGAGSPLGLLLTNDQVHEEVNKVLWKGMEFRFSSTELFGRFEARLTPFGRHALRRMTFHGCPASMPKFFRKHCPRLGSFHPSMRLEIRLPHCQPGNSWSEPGVGRICRRELVGKILWPAKYELAHFDIGKVHITGCITPAQRTLYLQLLEDIKLQGISKILEADICRRTCVQIGLGDKMCAGGNLHEMGCGDSWCVCRGDPPPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QHN3</accession>
    <name>A0A6A6QHN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_565422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004195">
        <property type="protein sequence ID" value="KAF2491721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QHN3"/>
    <dbReference type="OrthoDB" id="3875844at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2491721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32448" checksum="5DBEC3817E1D714C" modified="2020-06-17" version="1">MEQTGKAKYLAHALGEGITGLVNLASHWQISLPDDKVPCPLMDNPFPFLDLPLDIRVIIYSYVLSWPTLTRNFSRLGSLESILLNARKPLSSTDREKARVKPRLVTPAIFLVNRQIKDEAMGELARMPIVIDSPPLCVALTNRPFEITEFISAPLLKSCRRVLLTINTDLTPGDGLLLYRSDLTYWKPWEQCLSALFLDVWAPGTHDLQLLDVEIGGVWSAKPFQDREIKQVSKKKRSPHLRSKCYRQSVLQQMRFGLRSLGPGVKVTVRDPNGLDIKHLLTRASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QI78</accession>
    <name>A0A6A6QI78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inorganic phosphate transporter 1-6 /Pi cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_621808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2491167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QI78"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="188"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="236"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="350"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="393"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="573" mass="61346" checksum="D7EF3AF45E4B9BFE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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        <name evidence="15" type="ORF">BU16DRAFT_620437</name>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 269.34</strain>
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            <location evidence="1">Mitochondrion outer membrane</location>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18876" checksum="09E5A9707BB1FE8E" modified="2020-06-17" version="1">MSAPLKSSTIVAVSAGAVVTGLLAYAVYFDHRRRTDPDFRKALKRESKKQAKAAKEEAQLQSVQQKKLVRQAVDAANEEGFPTDAEEVEAYFMQEVARGEQLCQDGAEAIDAALCFYRALKVYPQPRELITIYDKTVPKPVLDVLAEMIAVDSSIPIGKPTPTGSAGSADGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2492112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="571" mass="63546" checksum="E4F925A82BDD04E0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIT7</accession>
    <name>A0A6A6QIT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_99308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2491964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIT7"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2491964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="548" mass="61325" checksum="7AD577AD39FCF104" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QIW9</accession>
    <name>A0A6A6QIW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Silent information regulator protein Sir2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_529712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2492378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QIW9"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2492378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="325" mass="36054" checksum="467D2247276E7605" modified="2020-06-17" version="1">MADKSAQAASRKSSKFQKELQDIHKKQQKRKLKSSIELDPAINIDEYTAFAEHLKSSTRILALLGAGLSAASGIPTFRGAGGFWREHDVTDLASPEGFFKNPSLVWQFYNYRRHQALTAMPNRAHIALAKLAKQKPGFLAITQNIDGLSEQANHSPSQLERIHGSLFEVRCTNKACEFQETNYTDPIVPALQLPEDQDIGDANFPLREVPRADLPHCPKCVDSLLRPGIVLFGEAVPQPVTERIGEWLDKGQIDLMLVIGTTAIVYPAAGYIHIARVNHARVAVVDMEVKDGDDVQREQDGDWFFQGDASVIVPELLKEVIGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ24</accession>
    <name>A0A6A6QJ24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">BU16DRAFT_529410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ24"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2492024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="338" mass="36763" checksum="C11BB346AB5BC5B6" modified="2020-06-17" version="1">MAPSATTPEKSLAPIDPQVLALRKVLTSESAPLAHRFRALFSLKHLASLSPPTPQTRPAIDAIAAAFTSPSALLKHELAYCLGQSRNDAAVPYLRTVLEDRKEDAMCRHEAAEALGALGDQDSLSLLRGMRDDAQELDVVRETCEIAVERIEWEHGVTRKDEQLKQSDFASIDPAPPLPQASSKPAIPELQKTLLDTSLPLFQRYRAMFALRNLSSPPDLPTAVPAVQALASGFQDPSALFRHEIAFVFGQLSHPASIPSLTETLSNTKEASMVRHEAAEALGSLGDEEGVEETLKKFLDDPEQVVRDSVIVALDMAEFEKNGETEYAIIPEAGLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ70</accession>
    <name>A0A6A6QJ70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_584217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ70"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="594" mass="67597" checksum="2F85DFD4A600F4E5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJ87</accession>
    <name>A0A6A6QJ87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_103495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJ87"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2492094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="46756" checksum="7E196E221A976ABE" modified="2020-06-17" version="1">MTGFGRSNSLSINTGSSLFGNTNANQGQQSAGLFGASTNASQPQQSGGLFGQQSTSQPQSGGLFGASATAAPQQSGGLFGNLQKPAQQQTGSLFGQSTAQPQPQQQQTQNQPQSGGLFGNLGQQKPATPSLFGSNQAKPSPSLFGASLQQPQQQQTQPQPSLFGGMAPQNTQANTLGGGLGQWGQTQQAASFSQHTGAGLGYEDAARIRGTTQFTDLKISLQNDIEAIEKSIQDHISWARKNTESLAAHGAHVAQLPPDVAYVQEKFKTMELAMDNDVVALDHVKQIQKKDEQDVQLLHRAIQNMTLPQHYHYASMRGLNAANTSSSAAAATGDDDDQYGKPVDLVAYFSQRGEALDATLTQYNKQIREIEAHLRTVESGAVQRERELMAQAQGGSTRGNEKQELFDALKAIEGAIFQVASKVGTAREMVVKETLGAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJC2</accession>
    <name>A0A6A6QJC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">BU16DRAFT_514956</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJC2"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="276"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="451"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="469"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="486"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="614"/>
            <end position="615"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="620"/>
            <end position="624"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2492512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="62571" checksum="2431525886C9EBB9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKV4</accession>
    <name>A0A6A6QKV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_592462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKV4"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="302" mass="34113" checksum="A70A52DB9410C74B" modified="2020-06-17" version="1">MADFDDFESPQSLVIPKKESPTPLASPQKPPPLQITMESLPNEDKASRNGTQCDEGEASAQRNWPVDRIREDSMQVQLESNLGKHACEQPQHMHAKSDRVPAKRPHYDSLSQIKEIVNDTKIGFKAGREEGPATRRKYEKVLKTPAMQQAARNQMETSRDYRVEMSQHRLRQIQAENERVVGMANVEEDRAMKMAEKKEIQEANQAKAICAEAIKMAAIRRSMEVAKAETARKNAVAEANMAYQIKRAGQLMEQTTANMQCDMFLQSLEKVKEKSWLRSELDKLSNGRLEATVEDSEQAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL13</accession>
    <name>A0A6A6QL13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_620061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL13"/>
    <dbReference type="OrthoDB" id="3786098at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025599260" evidence="1">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="116" mass="12683" checksum="2C19B8BA62B58C4A" modified="2020-06-17" version="1">MRLATFLLAGVAITAAIVNGLAIQKRTTAVTVYTLPSLLGTSTTLPSTSSCANLDDAWDEKIRSLVTVAGYRCDFYVNLDCKIVEDGDVLRYGWTRADMLPVRFDAKIRSVECGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL32</accession>
    <name>A0A6A6QL32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_96489</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2493045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QL32"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2493045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="231" mass="26493" checksum="D38435106C4E904A" modified="2020-06-17" version="1">MPRTPVERAVSRWTAIIIPLIMIGSAAYGTWCIVVKVAVEYLLNPPKSYRRNFHIHPRHGAAIAVLVLYFILLFLMAITYFRTLQVIWMDPGYIPLGNASQKGGIPGPEFTAKDAFVCDSNGKPRFCDHCNNFKPDRTHHCSEVERCVRRMDHFCPWAGGIISEHNMKFFLQFLFYGFFYNLFLIVTIGVLMQERKRKVSRYFCFLASFISFAIFGSGPLLDYKSGKPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QL46</accession>
    <name>A0A6A6QL46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_592578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF7580"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="565"/>
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        <location>
            <begin position="190"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2492766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="565" mass="64048" checksum="E7661BB5265EA871" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLN0</accession>
    <name>A0A6A6QLN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_541664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
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            <end position="333"/>
        </location>
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        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="358" mass="39785" checksum="C31FB51EC5CAD447" modified="2020-06-17" version="1">MPTRATQLSGTGSPSTPELQISPSRSPIPTTPVRGPNPRDRQTSEGSEDPRDLGSPIPTHNSEAAAAATDLNAEDQTTTCIEVVEAPGNTIAEALADLRILALEQPPVTAEEIEIRRLARRQRDCNTSLGNLGMHLTSMEDLYQDIGVRYHLTTDIARNAALTREARDVLRNAFSGEPRALMPLWDNHRRAVAHHNILRHALKEQIEDEVVYFARVSRLMERAVEEGDTFYGHLQEMKGLVHYIEDIEVEFATSGGHHRLHRAIADARRSEGYLVDLRVHAWVRALPETPRQLALRLPLTEIIQNVFCPDERELVSGSETSDDVSGDDSEDGSEDRSENGSEHQSDSEPGESRIFESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLY3</accession>
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        <recommendedName>
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    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_573713</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
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    </dbReference>
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        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
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        <property type="entry name" value="SANT_dom"/>
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        <property type="entry name" value="SLIDE"/>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="212"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="508"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="874"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <end position="1076"/>
        </location>
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        <location>
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            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2493395.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1127" mass="129031" checksum="E3A4BC5DCA72A9DD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMC4</accession>
    <name>A0A6A6QMC4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_512873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAF2493140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Positive regulator of purine utilization"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
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            <begin position="905"/>
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        </location>
    </feature>
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        <location>
            <begin position="142"/>
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        </location>
    </feature>
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        <location>
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            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="910"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2493140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1031" mass="112987" checksum="EB63F79B76005CB3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMS9</accession>
    <name>A0A6A6QMS9_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Carboxypeptidase S1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BU16DRAFT_464880</name>
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        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="564"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2493300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="582" mass="64244" checksum="B48AD6C39B7490D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QMZ8</accession>
    <name>A0A6A6QMZ8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_550752</name>
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        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2493670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="294" mass="31538" checksum="5C8320E002A52891" modified="2020-06-17" version="1">MSSEEFPIPISPSITLHTLLSAPSQSSDRPALLLLHFWGGSNRIYQPSISLLQARYPIIAPSLRGWGTSSAPADATAYRITDYAADIVALLLHLQMEHPTLLANGIVIAGHSMGGKLAQVLLSYKEVAPLVRGLVLIAPAPAGRFALPDDMREQQIHAYDSIESASFVVENVLLGKAESVSKAAKKELAEGMVAGSPGARAAWPEYGMAEDYERAVVESVEQYQRGRGQLKVLVIVGELDRVEEPGNVESRVAVALRNTGADVKMDRMTGVGHLVPLEAPETMASAITAFVESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QNW9</accession>
    <name>A0A6A6QNW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_464302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2493819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QNW9"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2493819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="26031" checksum="6BB1E35E94084228" modified="2020-06-17" version="1" fragment="single">SYESPMSLEGKLGFVPEPNGRGTRGLLWSCVFTWILCLWVLFHINIPTPNESTRKVAGPKTWFFFLGIIGPEWVATMAFTQFRDAQQFVIQMLRQLPLTHWTPTQGFYCGMGGFAIIPPEGLPKQFPVNTQQLCWLIENGHVKPPTITLKEIRDKSKMDSLLKGFALVQTLWFAAQYIARNVQRLDTSTLEVMTISYIVSTLPFGLLWWRKPYDVDSPTLLEPHIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QPI3</accession>
    <name>A0A6A6QPI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_512287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="MU004191">
        <property type="protein sequence ID" value="KAF2494036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QPI3"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2494036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="288" mass="32403" checksum="432D2855B07D6818" modified="2020-06-17" version="1">MPAPLLGESESCNAAPQPVSPLVADTPPPLPDVCAKIYNRINAFLDEKTDSQRLKNLQEQTRISLDVISQALDRYSLSELSLSYNGGKDCLVLLILYLYGLHAKGLTRPTPNNVHSSHHEPIQCVYIQSQHPFQEVEDFVASSASIYSLSLDHYAKPMKAAFADYLHDKPSVKAIFVGTRRTDPHGAALTHFDPTDHGWPKFMRIHPVIDWHYVEIWTFIRHLQIPYCVLYDHGYTSLGGTTDTLPNPALLRDPTLAQNGDRNGAGTLKYRPAYELVEDEEERLGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQE4</accession>
    <name>A0A6A6QQE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_589184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQE4"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="87" mass="10181" checksum="8216A9D4DC771273" modified="2020-06-17" version="1">MDSYPLIRQRITPIYILRRRLLKHKLFLTSIFLQGCIFVIGLPALNRHRTRLIRVIDSLHHLRISGINAVFLKASRITCELSKQCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QRK4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 269.34</strain>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="32430" checksum="7B35FE0202CF8D57" modified="2020-06-17" version="1">MAPIMSIRRLVLIAVPLFFQLGSAAQQCYNPDGSESEDVPCSSDSSYQTFCCSPGSQCILDPGPLCQTSSGYERGTCTVQDWSSGACPKFCLADDTDQRVDRCTAKVSNGNFCCGYDADDDACSCATNNNTFPLYAYSSIKVAQSAAASTSISSASSSASSVSSVATTASAASASNSVSSSSGGTTITGTAASATNTGSPSPSPTEAASSGMSTGAKIGVGVAVPLGVIAIGILGFLAWRQRKKSNAAAKTVYPAELPSQGHQGYYDPPPNEVKYAHEGSVGYGGGGINSPQQPPSEMYAPPPGQQMAYEMEGGGVGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="227" mass="24715" checksum="094A7273EE358AAE" modified="2020-06-17" version="1" fragment="single">SSIPNAKYSTITNHTVTPPGWSSHPRIDRSTLTNCTLAGLSEKTVFDRSRLTDTTVTSAASAGPPSSVSIARNGKSHFDRSVLERAHVTDSYLNRSTIKDSTMNLAHADRSTVSGTQCVISSSRLDRSTVSDSFISGDSVAERSDVKEGSEVSGKSNLSRSRVTASRVRDATRLDRSTLKNCSVENSRAERSTLEDCEVVNCKLERTKFTGMRLANGRWERGNLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2493717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41388" checksum="529A4AB3CB2A3056" modified="2020-06-17" version="1">MPGPRTLERYSRIAHAPLSTYILKLDICRQYQEFDLDEMPPVPQVPSLLLEDLEESPRKEDCVALVSGSDAFAGCKDVWVQSITEQIAGIKLARDDLVHIDLVQNGDELVAHLQWPLASPASESGLAYSNLCATSGEVLWSHPADYEMINIPPVDFRMFSDAEAFGWRKVSVTNILHPRLYDRFLASKYALATKFSSFSNQALAECVPYSHRTQTGDKDADKKNLVRFLTQARISFHGGNAGFKDASHSNIVQTTTDVYIALGDSDWQTGSGPSKVKRILVCATLLGRTARVNDNHTVADGFSVPGSSAHADTLLTKEDWLHADAGQVLPLYEIEYVWTPQKQQHLDAYALHASGLLTGFDRARLPSEWCRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QSE6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Bills G."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3538878at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025593986" evidence="1">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="241" mass="26288" checksum="C7013007ACBADDDF" modified="2020-06-17" version="1">MRVTVIIHLLTLLAPLAVAFPSFNDAATPVKRNLIPDPVRPFTVKAFVSPHPEGEGLSGYNLIARHGLFYLSKTGRSDFKCKPLHRDCGPDVVIFVTGQGEAFLDVLIPGIQQLYIDPASGALSYSPAPFSKFFPAAGITPFFTHMGSNPAGLVATDQNGTLRNSPATFNFIGSGYAANGYWFACKVPGGDDYQVFTYLTGFQFEDCESGIVLAALDFVGQPYIWEFLIYSSTIRHPPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSG1</accession>
    <name>A0A6A6QSG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QSG1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="107" mass="11707" checksum="0A920A87CB495602" modified="2020-06-17" version="1">MRTNWPMNRSRPEFLSGFSARFAAVLGEAAVFAQSIPQLIDDRCIDREGYRDLRHVVGGRGGQAANWVPSGPHPGISVPLTPFQHEAREIGLAGSGRSARASWDHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSK3</accession>
    <name>A0A6A6QSK3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <location>
            <begin position="2056"/>
            <end position="2218"/>
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            <begin position="1"/>
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            <begin position="1608"/>
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            <begin position="30"/>
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        <location>
            <begin position="1616"/>
            <end position="1630"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="PROSITE" id="PS51194"/>
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            <dbReference type="EMBL" id="KAF2495114.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="2277" mass="255468" checksum="AC4DDD0F4C829692" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSP3</accession>
    <name>A0A6A6QSP3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
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        <name evidence="8" type="ORF">BU16DRAFT_562621</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="26"/>
            <end position="266"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="374" mass="40434" checksum="291E82CE7A7B5F1D" modified="2020-06-17" version="1">MLKQMALTLVVVNGIFLSLACITLGLRVWIRSTRGALGTDDWLLLVGLLLFAVTVAMSTMSAHYGLGVHNYGASAAEMQNGVMYFALWQLFYVTSTVPVKASICISLLRITTKKLFRGILWALIVLSSISTFMACVVVWSTCRPMAATWDKSIKGAKCSSLEMIIALSYLVSGVNVVTDWTCAILPAFILWDIQMRTKLKFSVCVILGMGAAASTATLIRLKAIPSYRNANDYLYGIAEIAIWSTVEIGLGIIAGSVATLKPLFNKVFGSSTDPSSYADGRTPRPYPGSYRLHDVSKNKSAIETTITGRGENDRSDISDEDTASQRRILGRAGAGLSSKQNGGGITVTRDISVEAGSNADLKSTERERRVADMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QTW7</accession>
    <name>A0A6A6QTW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BU16DRAFT_389474</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025665751" evidence="3">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="293" mass="31359" checksum="FD1D6B5F42761E6E" modified="2020-06-17" version="1">MLIAALLSTRRTSSAWLFFVALSRFSIHTAASNLTCYYPDGLQNRGNACDPTSAVSQCCGPGFVCLGNGLCLPGPTVRKDYDWKYYRSGCTDPTWDSPTCPDICLGPKDSIDSGQGVQSCSGGPNRYCCAHSRHTDCCSNSTNIFTLGLANISVSIGVGVGVGVGGALILVLSVLFFLRHRRRKMGAKRSPEFGSHGFEMGQDGAGDGGGAVVKDAQFFAMREGEGDGDEIRAHLPSGPLELESSPRFELGVLPDHDERALQGEGTEGADGERNRYPGRYFKEDGLHRHEVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QU53</accession>
    <name>A0A6A6QU53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_527425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QU53"/>
    <dbReference type="OrthoDB" id="10378414at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2495644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="203" mass="22776" checksum="8D0061C7222C4412" modified="2020-06-17" version="1">MLTVQTAIKKYHTSVYNYHMADLQDITDSHLAAINEAEAMAALQSNKPTPPLADQLTELSNSLTSLAKGIDSFFEGLPIVYAKDPRPYPDPNLHFKAHVRTMLAMLQPHLDVHRGVFRALEPYRKAGEQGHLVRSETSGRQVDELEKLVKEIKEVTRVVHRTFGYPGVPRSRGVILECLKGVQQSVKREQELVRVLLVEGNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QUP2</accession>
    <name>A0A6A6QUP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_538486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QUP2"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="94"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2495862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="32401" checksum="C217DB1FE84C9D4A" modified="2020-06-17" version="1">MSPSSTTISSNSLPIEAPDKESLIKRNPHADFPAVQASRPSYPTPPFNLTKTPNPDWLPGTGASDSSWRQHALRIVDPNGPNRTTVQNYKLMISTTVPRPIALVSTVSSTGVKNVAPFSFFQAVSQDPPLYSLSFVGQDPNDSLRNVLESGECCISLVSDWFIEAANYTSINTPPHLSEWELAGLSPVASQVVKAPHVGESAFSVECKLHSSHDIIGKSGKRSATLVLVEAVMFHVREDAVDEAGVTADAGVLRAIWRGGGITYGVCANAWELPRPETWRVEREREDVKKLDKKTNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVC0</accession>
    <name>A0A6A6QVC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_460361</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVC0"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="14">
        <location>
            <begin position="72"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="15">
        <location>
            <begin position="373"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2496381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="458" mass="48900" checksum="4F7DA262680F586D" modified="2020-06-17" version="1">MSAKRGIRLLQPAIAGAGRLSSPPNAASNALHSLRPLSTPSRRPRISVRTPAASNSQRFSSSKADEPAKTPLYDLHAAHGAKFVPFGGYAMPVQYSDLSVGESHHWTREKASLLDVSHMVQHHFSGPGADAFLSLITPSSLTTLKPHHSTLSTLLHRETGGIVDDTVITRLDATHFYVVTNAGCRAKDLEYFQTELAAWKEAGNPDVKWNVLEGQGLVALQGPAAAEVLASVIADPEKVKLDELYFGQSKYASIRIANWNTSPEVLISRGGYTGEDGFEISVPASSTVAVTEKLLSAAPETVRLAGLGARDSLRLEAGMCLYGHDLDDSTTPVEAALAWVVGKDRRVEGGFHGSSVILSQLKPKKDGGKGVTRRRIGLVVDGAPAREGASIVDAEDNVIGTVTSGCPSPTLKKNIAMAYIKDGSHKSGTEVAVLIRGKRRKAVVTKMPFVPSKYYRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVS3</accession>
    <name>A0A6A6QVS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_559866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVS3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025494303" evidence="4">
        <location>
            <begin position="17"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="448"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="576"/>
            <end position="577"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2496541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="594" mass="63124" checksum="FC5BD47417BC1443" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVU9</accession>
    <name>A0A6A6QVU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_538844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVU9"/>
    <dbReference type="OrthoDB" id="3940153at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2496282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="404" mass="44897" checksum="635867129EDFF146" modified="2020-06-17" version="1">MLRYPATRHPTRQKQVLVERSSVNIGGGNSTDQAAASIVAWTSTVNMHVNHEDYGEEMPYHSRMNSSTRHQSSWPPQLLPNPRAGYLAPPQTMNAHGREHPERNCLPFGNNVQGNSPVGYVFNVRSGEPSSTDAWSSPATNSNGPVWSPHGPQDPYFGQQVVSPGPEPPQSLSLSRSPSDRSWNHDSNRRKYEGPFRSISDETLKQHGMYYHGQANEMFPNQGCTSPRVQSYNSPRDPDQSSILVSPGFDNGISQLQQTVSMNASIMDEWRSGNQPGQIVSQYSSHDQHEAPGYNGKSMQSMQTPIPMSPGPSPGGGSSELSSPQSPVLRCGYPHCKQTFKGDSRAGNRKRHMKSAHRDQIGQVLSCSEPRCTKKFKRSDSRLKHERKKHPELQRLPPRKRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWE7</accession>
    <name>A0A6A6QWE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_458901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWE7"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="560" mass="61520" checksum="B639FD6B8FEEC940" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QX75</accession>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 269.34</strain>
        </source>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="207" mass="24357" checksum="B991A3C05403B548" modified="2020-06-17" version="1">MDAQQADGESTSGINEWKKKAPYKVHDKGEDFKALYDANCHCGKVKYELSRQEPLDSKLCHCSTCQRQHAAPFQWAAIFHKEDINFLQGHHDLEWYDPTAKSIEHKLPCKVRCSFCHSPIMDEGRNMILLFPSLVNFKSKEDRELFKPRCHMFYDQRVMDIPDGLPKWTGINNESDLIEDSPPEKVRELERKREEEREERFKKGENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY33</accession>
    <name>A0A6A6QY33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
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                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QY33"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="135" mass="14594" checksum="6E4AE58793FEA34D" modified="2020-06-17" version="1">MIQLKTLVNCIDNSGAAIVECVNVLRSKRPAKVGDRIVVVVQKQRNFGPESGPGGAVSISAANKVRRGDIRHAVVVRTAKKYQRPDGSVVKFDDNACVLINKAGEPIGTRLNGIVAAELREKKWSKILSLAPMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QY97</accession>
    <name>A0A6A6QY97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="17">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BU16DRAFT_458740</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="17"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2497092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
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        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
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        <property type="entry name" value="MGS-like_dom"/>
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        <property type="entry name" value="MGS-like_dom_sf"/>
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        <property type="entry name" value="PreATP-grasp_dom_sf"/>
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        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
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        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OTCace_N"/>
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    </dbReference>
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        <property type="entry name" value="AOTCASE"/>
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        <property type="entry name" value="ATCASE"/>
    </dbReference>
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        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
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    </dbReference>
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        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 27" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="569"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="1104"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="26">
        <location>
            <begin position="1361"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497092.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="1846" mass="204209" checksum="33DF41909EF8D800" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYP3</accession>
    <name>A0A6A6QYP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_458095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rbsml_uS13_C"/>
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    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
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        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
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        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBOSOMAL_S13_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2497194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="155" mass="17788" checksum="417DB498B9A0D460" modified="2020-06-17" version="1" fragment="single">QSLVTGEKSNFQFIIRLLNTNVDGKQKVMYALTKIKGVGRRYSNLVCKKADVDLSKRAGDLTSEELERIVTIIQNPTQYKIPEWFLNRQRDIVDGKNSQVLANGVDSKLREDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZ73</accession>
    <name>A0A6A6QZ73_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BU16DRAFT_537387</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QZ73"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2497778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="299" mass="31427" checksum="DB32EB0D75542693" modified="2020-06-17" version="1">MALFTRHVAVFLLSANVVLGNPVFMPKEMAKESTPINWGLVPTGSGLVPTGSGLLPTVPTGLSPTPSKYILPKDGFPTFGLSLAHGQLATSLPTTSPCLPRPSSAPPPSPTTQWGNLPMTLTSLPTTIPILTPSPATPANPVVSATTAPTAGACFLQLYQSRHSIPAANELSEFLGVQLWKPPFTDVAHNLAFAYGSVLERDLAGVGAMQLGNETWLSSPLDLGLVELPCAGQYDVRVTFDSKSWSLLSPPTQPPATVKLPTEWGVGNGPGFEVPATPGGGGIVEWRRFDVTFDCGFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZI4</accession>
    <name>A0A6A6QZI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidyl prolyl cis-trans isomerase cyclophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BU16DRAFT_321771</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="90"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6R0J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2498029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R144</accession>
    <name>A0A6A6R144_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_457855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
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            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
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            <dbReference type="ChEBI" id="CHEBI:85099"/>
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            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DECR2-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2497553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="314" mass="32732" checksum="0D95C4F8ED336461" modified="2020-06-17" version="1">MPLPKSEYLSEVWKDGIFNNKVVFCTGGAGTICSAQVRALVHLGANACIIGRNVEKTENMAKDIATARPGAKVIGLGGVDVRKPEALNEAAAKCVKELGSLDFCIAGAAGNFLAPMNQISSNAMRSVIEIDVLGSYNTVKATLPYLVESAAKHKTDGKTPPRNGTGGRIIFVSATLHYAGTPLQSHVSVAKAGVDAMAHAVAIEQGPRGITSNVIAPGPIADTEGMARLSKHSSAKDSMKKVPSGRFGTVKEIADATVYLFSDAGNFVNGEILVVDGGAWHTAFGGTEESFKYPDFLLTDEVVTGVAGGKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1U8</accession>
    <name>A0A6A6R1U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BU16DRAFT_303505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R1U8"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="200"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="409"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2498738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="591" mass="65370" checksum="5B3F4C06E15CEAC1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2I1</accession>
    <name>A0A6A6R2I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_506092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2I1"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2497607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="228" mass="24467" checksum="E117C74F67D16001" modified="2020-06-17" version="1">MPDQAFNLTVLISGNGSNLQALIDACASSALPSTRITRVISNKADAYGLTRASNASIPSTVHSLDPYKARFPNAKKPKLSSPEARSEYCKDLAKLALEATPKPDLIVCAGWMLILTPTFLTPVAEAGIKIINLHPALPGEFDGIDAIGRAHKAFLAGEIKRTGVMIHEVIEDVDAGQPVVTQEVEMREGESIEELEARIHEVEHGLIVEGTRRTLLEIGERRKAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R381</accession>
    <name>A0A6A6R381_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_559583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R381"/>
    <dbReference type="OrthoDB" id="3795850at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="379" mass="43114" checksum="BD13B9D67E832C50" modified="2020-06-17" version="1">MSALGPLYSSETATGITWGMPVSVVALGASLDRFTKLLPQLQTLRLCHRYGKGDDVHLTKLPNELLEMVINELYHIEPRTTWPEWERELKCFEGNCTPISHFEGHDGLDPHDLLLQYFEHEDPYSLPENEIKDRLHEALLAYQWHPPTSVRESHPHYQRKMQWKCRLTQDPPGPCGFAKYDHILKAHFGLEAFIAHRKVPDKLRSTFPCPGWDSRCNTTVCYLTLPEGTIKQEADDEGGLTEEPVSRPNGWKKYGNSSFMTCYVDPELLNITKNQKLRFKKVQTVLGIGPQLHLTGLTRSQAGKTTAKTDDCALETTKTKLNNAIDRLAASRVRREHHGGDAILEEIETVLLPELSALMEWPKLLNVAKTTFGLQVRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4B8</accession>
    <name>A0A6A6R4B8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_454661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4B8"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF15">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01167">
        <property type="entry name" value="INSADHFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="264" mass="28367" checksum="E244AB48E4EB9D56" modified="2020-06-17" version="1">MSFPYKHVLLVGATAGIGKAMAHRLVQEGVKVTAVGRRQDRLDEFVTTHGANKTSAERVDIADSNAMPKFAAEYIPISDDTSITSLFQSTIINLAEPAKWDMQAIHNDVSVNFTSFVNLTHAFLPFLLNKRSKTSLIYTTSHLAYIPAAGLSGYSASKAALSSFILCLREEPRNSSIKVIEVSLPVLTFLGELHDYMGPAGRELGMPVSDFTDAAFAGLAAGKDEVLVDDLADAGTAVEKLSQTVGERRSACNGLSKMLRGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4M3</accession>
    <name>A0A6A6R4M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_303201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4M3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="146" mass="16412" checksum="A6CAD082C7C64873" modified="2020-06-17" version="1">MSSQMTSLVEAWHRRTNDGVKSSVSLPHFLFIPSLVIPQPHPDSLQCCASIVSTSAEPLQRRAIATVVPQPCRVSAEIELRRRGHCDRSWLTTAFEYLYCARQIGDRSKIRRPYPSKLCDFVSTTVKASPIQDTKSRLHTGKSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R510</accession>
    <name>A0A6A6R510_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_547989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R510"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
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            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6B5"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2499263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="167" mass="18183" checksum="0CF1E89A85CE8EC1" modified="2020-06-17" version="1">MAPLKVGDSFPDDVKFEWAPITDSDPTACGLPQTYDASKNFKGKKVVLFSVPGAFTPGCQARHLPPYIQNIEEFKKKGVDIVAVIAINDAWVMNAWGKVNGVKGDDILFFSDTKTNFSKNFGWDAGMGDRTGRWAMIFDDGKVTYAENEKSPGDVIVSGAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R6D5</accession>
    <name>A0A6A6R6D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_454576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R6D5"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2499440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="399" mass="42642" checksum="37868DA19CB3E62D" modified="2020-06-17" version="1">MSARTVLVIGGSWAGISTSHYALKHILPTLPKDDNFTYNVTMVTPSEEFYWRVAGPRACLSGEALPESKYLYPIKKEFAKYGDSFKFVKGTATALDTAARTVTVSTGGAPESIPYYALILAVGTHTPAPFLSLQTDSDAVKTDLDNFRKALPNAKTIVIGGGGPVGVEVAGEIAEYLNGTAGWFAPAKPAHPKAQLTLVCADKKLLPVLREALAKTAEKYLNRVGCDVVYGTRVESTTQTADGKTTVSLSGGKTLETDLYIDATGARPNTGFLPKTILNEKGYVDSDKTLRVTAAGERVYVLGDCGSYTRGGIIDMWDALPVVVANLKKDLSGAEVPDKEYKANLTETQVVPVGKSKGVGAFAGWKLPSMMVVMIKGKDYMANLAPPIVSGKQWDKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R7G6</accession>
    <name>A0A6A6R7G6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_578999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R7G6"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2499427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A6A6R7L6_9PEZI</name>
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                <person name="Bloem J."/>
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                <person name="Andreopoulos B."/>
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                <person name="Castanera R."/>
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                <person name="Gonzalez J."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="172" mass="19375" checksum="70580CE645E35EDC" modified="2020-06-17" version="1">MAPPNGTKAAQKGDMGPPKTILKKTTTKETATHSTGNQKSRTETFTDEQELDEVETESSLGSQSDPLQELMARIKRDRATRKVAARARIRSVHDARVAKTRTTITAFFDRHDEKLTQARQAHLTRLKELLARKTALEAKMVACVRRLRDGYVAHSKDLQLVLDARIELLTKR</sequence>
</entry>
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    <name>A0A6A6R7P9_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="EMBL" id="KAF2499880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="44498" checksum="340870B942C01613" modified="2020-06-17" version="1">MDFSFTTIALVPNLPRRLIFELPPFLYQSSRIGVDVVHGFRYHYRAKVQARHNQCICIDPASATFRALNVTEILENIIMCAGTPHQLRYRSINKRWRNVIDSSPKIQHRLWIRRIPSRNNGISFETRALKPIEATVTGVCWSCSQNHRVPKSKHLNPLLKKDRRPWPEWVYGLAPHYWAIDRHCWWVDDDGALTFTFNSPLSVSSLTGGINLGERTASWRDAHLTDPPVLKVNIDTLDWSFWGPTVLEWACWIVEDPNGVKIGEFIDALRELRSFWPHASKLEMLRAVLWGLWDLVLKPTVITMLILEFLTIELFLASYEEQSYSQVCYGFLCKGSYFPRMMDLVFRNWASRKLLQTVCFTKLSWIWDSRPHAKWHLNCAAA</sequence>
</entry>
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    <name>A0A6A6R855_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
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        <location>
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        <location>
            <begin position="18"/>
            <end position="173"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="173" mass="18350" checksum="F8C35BD357E7D56A" modified="2020-06-17" version="1">MRFSTASLLAFSSVALAAPSSPAQRRDLTYDASNPPQIFTDLTCKLSKSLTPGEPLSFAFPLADHLGTIITPALNTLVGHESVNDLDIVADNLCVNAQQDPHGGNGICQDSLQSIRDFVDAKTPLAQAQGYRCLLNLLCVAHTGVPYNSLCDYLLAGVDCIANRIIGVTAECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R9T9"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2501174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="409" mass="44791" checksum="2C61ABF5408C7033" modified="2020-06-17" version="1">MGKLSPESLQTLKQITEDACADPETGLPGTTVVVVGKDGKELFAHAAGKRGYGSSEPMTLDSIYWIASCTKMITGVACMQLVEQGTLKLDDAAQVEKLCPELKAVKVLQKDGSLVDKKRGITLRMLLSHTAGFGYAFFNNELRDYNKPLGYDEFSGHLKDIIQPLVHQPGEGWEYGVNIDWAGIVLERATGTSLNNYMQKHILAPLGLQNMNMFPTASMKQNLAYMNSRNPEGKLARYDHINRRPLVVEGNDVDTCLNSGGAGMFAKPQEYCQILATLLNDGTSPTTGAKILSKATVDEMFKNQIPDFPNFARQGVPAAKPWLTNAIPELYPIPGDKPQGWGLTFMLTEGATGRSKGTAQWAGLPNLWWWCDREKGVAGIICNQILPFVDMKTLGLWGAIETTVYKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA50</accession>
    <name>A0A6A6RA50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_614131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA50"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2500367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="311" mass="34445" checksum="D24BA1248733E8E5" modified="2020-06-17" version="1">MAIPTPSPFLRLPAEIRLMIYELLILPHSTKALEDDDPYTLPITTINPSNTAAPIAPRRTIYHTHPPRRGFLPIRSLPTTWTIKPHPSAAHLRETLPSLLPLNRQIYTEAATVLHTAYTLSFGASIDAIGPFFHDLSPFGKRAVRKLSLTKQALPFVSSSREDDWRAACACLTALTNPADASVDIDGSPPAVQEEPLLNLTHFTLAVETADQPSYPSAWDLIAPATAAEFAQLAQMRREDWALAPQADMLWAEEVRRIRVARGGVVRVESVGAQCPIVRAQNIRFWVKISKSIEGFGDWMREGMVMEGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA85</accession>
    <name>A0A6A6RA85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_614402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2500680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA85"/>
    <dbReference type="OrthoDB" id="4779287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2500680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="253" mass="26231" checksum="0AD8F464B7A1F8C3" modified="2020-06-17" version="1">MSIHTGFALRHNGSCPTGNINCGTTVSPFRGCCPSGYVCPHQYNLACCPSGQNCTATLLADAHCANDSWDMYDNGGFFCCQKDEVGYANTTTDSNGCGQPGYNTTSGELELRIVSTGQVSSSSSASATSSTTISISTSSQLSQSSQVPIHTSTPTANTSEKSNTGAIAGGVVGGVVGLALLVAVIWFSLRRKRKQSRSSVELDGSTLYSGVNGVNLLHEAGGNEIQQKYGHTAPHATPELDSIPVAELPTSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RA91</accession>
    <name>A0A6A6RA91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_500822</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RA91"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="471"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2501599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="537" mass="61098" checksum="02ED6BA751EC9828" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAM7</accession>
    <name>A0A6A6RAM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_450629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2501885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="63"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2501885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="435" mass="46616" checksum="3789FDA15C548FFD" modified="2020-06-17" version="1">MSRERHDSKVRGSDEDLANGLSKTSISVPEPELPSSQTILLLKEVKTPYTLTPDYPIPVPANDNEILIRTQVIGLNPIDWKAPDYNFGIPSLPHICGRDAVGIVVRAPKSTTTSNNPSRIKVGDTVIATSTDYRNTSKSTFQSYILASLSNTALLPASISPTTGAALGVAYVAAVLALGICLGIDFSALPLASAAANSAGPHLLEIVSKIPDEKLPADVIAECRRAQQEDGERQFAYDARKPGEAGMGDWIAVWGSSTTGFLISQLARLAGLRVALVVDLHKHGARLYSDGADLLVDAHDPGRAVAVIRGVTQGRLRFGVDTVGKETAEHLADALANDEGEEGVERHLVGLTGLPKEKRPGVVHHTVPIKLFHEVLEVGEGLMKWLEVLLAEQLLKPPEIEVVEGGLESVNGALDRMRRGEISGKRMVVKFPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RAR6</accession>
    <name>A0A6A6RAR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_556118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RAR6"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2501641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19323" checksum="0F1FAAE501604278" modified="2020-06-17" version="1">MAFCPKFKSSILTALGIRAASPTSPIPSYTAHYIILNFIFAYAALSSRGLKNAYKLDHNVSPREDVSKYGERAVASGKITQAQLNMLKRNEGAHANAVENFTMFVGSLLWAHQAGVPVEVINASALVYTIVRVVYAGLYLGIASHKASYLRSMAWWAGNAVCFRLLWLGGKVVNQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RBN4</accession>
    <name>A0A6A6RBN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_501231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="MU004182">
        <property type="protein sequence ID" value="KAF2501822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6RBN4"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="514" mass="54096" checksum="62C780425F8D5EC3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6RC30</accession>
    <name>A0A6A6RC30_9PEZI</name>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAF2501942.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="393" mass="45658" checksum="3A0D9BEBF3FDD269" modified="2020-06-17" version="1">MAKPLSSSHIPVEQPPPYDVPDRIRELESNVVTLRNLVDTLQPRPPPTRCEYRFLKHLDAPASENFDDPKWIKEVLQEPGKVEVDRFCYQTHPPLSDSSVEDVQPVKQASSCDVQLLSSTSETSTNAVKALKDFLYISLLLTYSDSAHHKEILRHDIQSHQAWLRLHKLQSRLTTLFFPVDGFRMFPYAWSYFEAADSRSMRTLTLAIIEPCRVLGVSPRVALLMLRMFPYVAKPCPFLRFIGRREQVSAFWYTCPHAFAAKLCYDEHYLVDIVAPDLASAGALKEMIRRMASTFFVTLRSWSEFELNPIGQRRAKFARKPFDTLGEEDWLRRLWMRRALKRLRKEAAVEHQSHLPVWCRNLFGARSRRNERTGLCYILRNGLESAEHEHERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REF8</accession>
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            <fullName evidence="3">F-box domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAF2502834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="22260" checksum="2273C849E6FFEFAC" modified="2020-06-17" version="1">MANESKYAKQIHRLRAGPRPPSSIWPRTVYKTDGTSQRHYFPFLDLPRELRDLIYEYALVAKDGIHIHAVRVAAPSLERFHRWLPISRTLVQHRTVHNYFQRLRRFPRGPRHAPSQVIYSPRKLTYESDFAQDLNVQIFSVSRQIYEEASRIFYGGNTFDFGSQSNDKELSLVTCYLFLTDRPALALAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6REG6</accession>
    <name>A0A6A6REG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_521802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="380" mass="41459" checksum="063CEAC86EDB9D5C" modified="2020-06-17" version="1">MPTATTSNIRGWSGYTAALFFVSLSALAVKLMHLSDAAAALAELPFQDVVHSLTFPNKHRLREHYTGIEPLDVGLRFLVAAFLPGAAGWDLGCQIQQIYFIVSCLALVAIWAVEAGRVGNSRAVTSFTSVWPLLYQTIGGAIIIPLYYLFYIRESSQLDYWSPISQRIPTSYAKALLPSLIIGYILPTFFMYLPFPDPGLNITQGTIALWQVSPIIVNVLLFFISTTMGKEPATPKATASQSPGTLKYLDLIYITCFAITASTHIAVVTICLLSSSPQMSLKHALWRVPLGNEIAMSEALHYIFQVDFQIIFTAMVAGSFLTLWDLKRVGRMDISLASAATMMTMGVLCVGPAATAIAVSYVREGMLAVKNKRRPSSVAG</sequence>
</entry>
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                <person name="Bloem J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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    </dbReference>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="166" mass="19312" checksum="45A47877A7B4A984" modified="2020-06-17" version="1">MKHTPPPTSSSTSKALRMSYRIGRGEQGVLTFEPYKSTILPLWRFRTPTLARKSAQDIWERFEAYDEAGDFVGMDMCRKFLQMGMTRAKRYANHAGGRKYDKDTGEELAKSGTHKGAAEKLEASELFREVWNRCRKHEGYLARKEVFQAELKEWQKTERLKESRPT</sequence>
</entry>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Henrissat B."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489002.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="18678" checksum="DAF5B8E279222933" modified="2020-06-17" version="1">MTTSNFPNMCDGAPGLPPLAYDTWKQWLLVVELKARAAHIWQYVDILKPEDELTKIIKPTRPTMPGMTNKSNPDWKMAMRQYEALKRRYMWEFELLERRVPAILFLTLEIVDSIPQDAEFFHETWEFESTHKLLLDLELRFDLSSRQSGSEREDSETQ</sequence>
</entry>
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    <accession>A0A6A6QAA3</accession>
    <name>A0A6A6QAA3_9PEZI</name>
    <protein>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_473042</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2488916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="136" mass="15771" checksum="7F5327B15934A0C7" modified="2020-06-17" version="1">MLSQRALLRAAPRFVRTPAARTTVRSRFYSEVKLEGNADNAFNRERLAVKHHAAATSGLWRKLSIYMVIPALAIAGANAYKLWVEHWEHVAHAPPKSELPEYSYQNIRTKNFWYGTGDKTWFWNDKVNYHKNAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAK4</accession>
    <name>A0A6A6QAK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_531506</name>
    </gene>
    <organism evidence="6 7">
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            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004199">
        <property type="protein sequence ID" value="KAF2489099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAK4"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="403"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2489099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="57768" checksum="C4B007B076451DF0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QAR7</accession>
    <name>A0A6A6QAR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_225648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004202">
        <property type="protein sequence ID" value="KAF2488713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QAR7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="99"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2488713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="333" mass="37084" checksum="C6A3D2F5F492F041" modified="2020-06-17" version="1">MPLPSDLHIDVSKFDPAKSNPKTEEFNKKLIQIAKGGPRWYEVGAAKYRKMRWNGETPLPKPVVIESGVNGTLPSRDPGRELTYRLFKPEKGEVKGIYMHVHGGGWVLQSEAYQDGLLKYMADNTGLAVVSIGYRLAPEDPWPAGAEDCYDAAEYLVEHGKERFGGELMFTGGESAGGHFAVLIALHLLKTKPTFAFRGLLLHFGCFDLSGFLPMVDHHERALVIDRDIMKRYIDVLLPNTTIEQRRDPTISPFFADLRGLKLPPALFTCGTEDPLLDDTVFMSAKWMMWGNEAVVRIYNGAPHGFIMFPPGTIDAVQEGLDASTDFVKEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBF4</accession>
    <name>A0A6A6QBF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_471357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2489602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2489602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="558" mass="61961" checksum="8B714307E646C9AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QBR8</accession>
    <name>A0A6A6QBR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BU16DRAFT_531744</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="278" mass="29443" checksum="78154BADAD487C0A" modified="2020-06-17" version="1">MADTDSAPSANTSLPFDFVNPTGNPTILLIHGSFSTGHDWDPVISHLQKITAYHILAPDLPAHGRASALPFTVASASGHLATLIANEAHDGKAHIVGLSMGAYVAAHLASHNPERCLTVFATGFNIRDPSPSFLAPIAPSVFWGMQSATDLLPRSVVGWAVDADLSVSQKGVVTKALCAEILKMLEPASVKENVGVVRARMLVIAATKSGIVPSGDRVEDAKRIAELARGKGAGSGEVRVVKHAGMRHAWNRQDPDLFARAVVAWVDREDVVEGFLDV</sequence>
</entry>
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    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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            <authorList>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Ezra D."/>
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                <person name="Goodwin S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A6A6QCJ2</accession>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="101" mass="10808" checksum="6AF0ABFD5ABCEA5A" modified="2020-06-17" version="1">MGRHLGCASSLIATFPRMPSSQVLSITVINCMVLRFFASMFFHVAQEKAFHAHLATRSDVLVPTNRLLIAAPRESAPPGEGLVVNPSAFSTCSGSNYVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDA0</accession>
    <name>A0A6A6QDA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <location>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2490375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="224" mass="25494" checksum="A59400720F8AABF0" modified="2020-06-17" version="1">MELSKRARSISRVLGAVLARRCYKAKCFRREPPPPCQRLRNRWQRRHVDAPNRTEFWCVYPLRYGMKLVCVNVLTDRYGSQGLPRWVISTQASNFTPEAATTRPFRAVKPCSKVKVASNRMLDWAPACHRSLGSNLTAYTCPLLASLENDSSEAATTTAFRQFRCCKKLAWRSCMPLKSAHERLNVLQPDAPMASTPSLGSFTRTRLPKQRRQQQPHASGLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QDJ2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Baker S."/>
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                <person name="Bills G."/>
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                <person name="Gonzalez J."/>
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                <person name="Kuo A."/>
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                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
        <property type="protein sequence ID" value="KAF2489733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDJ2"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2489733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="356" mass="38013" checksum="C5C6CE3149C1BBFD" modified="2020-06-17" version="1">MEATPEPDVPLPPTTTTIPTTAPPPAPPSPTEPAPAPLSQDSIPPQQEPTPPPTPQLRPTPTTSTRLAKLRNLAISSTLTTARSTDSTLSRLSRLLSTPGGIDSFLCTLGYTLTLLHPALSYLLERRLRALATTIATKADGVLLPGETLITTFEAPTSTKLLASGAAGSKALASVISDYRIFVRLWGLLGIYTWGKGVWNAKLAEGAGGKEKVLRAVAWGQVASCAAYQVLENGAYLASKGVLVTPGWMGEAGKRREARWWVWSSRFWAAHVALEGVRLGVLFKKHVDSGKAEKEEVEKSSKEDKAWWRDAVSNAAWGPLTLHWSTEAGMVSEPLVGALGIVAGGVGLLEKWRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QDX4</accession>
    <name>A0A6A6QDX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_575289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QDX4"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2490605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22311" checksum="695D98EDD4723B73" modified="2020-06-17" version="1">METSDTFTLLPLNLDPTSKAISSATPASTALAEELTALNQLHRALLGLEAPHTVPPPPIPVNPKRSAQITKLRESGNADFRKNKFPEAIRMYSIGIDMALGRPGWEPSGLVREEVSALFANRAQAHMSLQQWVEGALDAESSVEMRKVGNAKAWWRRGKCLQEMGRVEEASEWVGQALEFEAAEADLLQLKKELDAVLAQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE32</accession>
    <name>A0A6A6QE32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_530864</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="MU004197">
        <property type="protein sequence ID" value="KAF2490369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QE32"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="132"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2490369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="457" mass="49938" checksum="ED0431983505DE8E" modified="2020-06-17" version="1">MDSMLPILGSSKSVLLLGAGFVTRPTAEILGNSGVSVTVACRTLESAKKLASGIKNASAISLDVSDAKALDAEVAKVSVVISLIPYTFHATVIESAIRNKKNVVTTSYVSPAMEELDQKAKDAGITVMNEIGLDPGLDHLSAVLTIDEVHKAGGKVLSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNPAKYYKDGKIVDVTSEGLMATAQPYYIYPGYAFVAYPNRDSTPYRVRYQIPEAQTIIRGTLRYQGFPEFIKTLVDIGFLSDEEKDYLKPGASISWKEATSKIVGATSRAEEDIIWAISSRTTFKNNDEKDRIIDGLRWIGLFGDEDITARSNPLDTLCATLEKKMQYEEGERDFVMLQHKFEIENKDGSKETRTSTLCEYGDPKGYSAMAKLVGVPCAVAVQQVLDGTISEKGILAPMSPELARPLMKTLTEKYGITFREKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QE46</accession>
    <name>A0A6A6QE46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_595170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
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        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
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        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <position position="212"/>
        </location>
    </feature>
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            <position position="337"/>
        </location>
    </feature>
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        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2490675.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="539" mass="57237" checksum="DA7629823A9DF873" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEF0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">BU16DRAFT_552930</name>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2490489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036322">
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2490489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="578" mass="62886" checksum="FEF116962B58EEE8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEF9</accession>
    <name>A0A6A6QEF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_544226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2489867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49202" checksum="5A900150F0FDFC09" modified="2020-06-17" version="1">MVYLAQGIPNGLLTSLPEELILDIIAHIFESSDESWESITSQPDFRSLLLTSKQLSRLTDTFRYRHIKLSPHSLTSLKESVVFLRDSALATSVRSVEIIYEERDPMQEKSLLSLVKLSLSPKDQELVTSAVADIGMPGVLSVDAWVTAILFRLPRLTALRLPPSTMEAELLTPYPPFEAFLEHPNRLQRLRKLSLATCWAVSRESLISILQATSLRTLEIEGWERDRLYLPELSSPIEHLILFPHSNDHLLPYLTEKNNIIKTFKALRSITIKIRSFPWSHHLLLLMSHLQAQKHSLEQFHLSTHSPSEPIDSEVSLVNFHEFSRLRIIFAPTVLIFRHLGNVPPSLAKTLPPSLECLTINGYEPVPGRIIQLASGDFPNLKSVTVRDRGNFPDEVYEAFRAADIMFTDRVFLLNLHPVSLSRYFVITAVQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QEV6</accession>
    <name>A0A6A6QEV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_132136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QEV6"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="373"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2490701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="484" mass="54703" checksum="78D0026E47347695" modified="2020-06-17" version="1">MSPNDVYQDPLNSRYASTEMKYLFSPRNRFSTWRQLWVWLAESEKELGLDISDEAIQQMKAHQVIQDEEFAVAAEEEKIRRHDVMAHVHTFGLKAPAAAGIIHWGATSCYCTDNADLIFLRDGLDILLPKLATVIEKLSSFAKEHKDLACLAYTHLQPAQLTTVGKRACLWIQDLLMDLRNLERARDDLRFRGVKGTTGTQASFLQIFAGDHSKVEALDELVTKKADFKSAFIISSQTYTRKIDGDVLQALGSFGATCERIGQDIRHLAAFKELEEPFESMQIGSSAMAYKRNPMRSERLCSLGRKLQNLPKDAMDTYAAQWFERTLDDSAIRRICIPQSYLCADASLILLNNISSGMVVYPAVIKKRVEAELPFMATENIIMALVAKGVSRQRAHEAVRVLSHEAGREVKQFGRDNDLIDRIRGKEFFESIVPDLEKLMDPQTFIGRAPEQVTSFYEKDVTPALKKYFDAKLIKSGEAAELHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QF34</accession>
    <name>A0A6A6QF34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_552512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QF34"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000006">
        <property type="entry name" value="Malonyl CoA-acyl carrier protein transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2490781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="376" mass="41068" checksum="A67068C501163D8A" modified="2020-06-17" version="1">MSTATTKRPRTALFFPGQGVQRVGMITPWLDAFPRTVLPILDEIDSTLRIPLSRIIADGPNATLTATENAQPAIMATSILILRVLEQEFGFDTPSRVDITLGHSLGEFAALVAGGYLTFTDALKMVRRRAEVMAGCSAAAASATEGGEFGMVALVCESEAHMRDLVVGIYEFLGLSSAGSKSDSANDLPAVEQVSIANINSKNQIVLSGSIERINTLMTNLRQFGGHDPRHVRLKSDSPFHSPLMKPAEEMMKKLLYEPTEEGRDIITWPGVMPCISNVSARPFKSEDQLKDLLARGCVDTVRWWNSVKYLDQEEKVRRWVGIGPGKVGRNLVGKEVGMKGAVKGGGVWGITSPKEAEEVMRALDDTEHIEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QFB4</accession>
    <name>A0A6A6QFB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_621501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004196">
        <property type="protein sequence ID" value="KAF2490799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <position position="478"/>
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            <name>Fe</name>
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            <dbReference type="RuleBase" id="RU000461"/>
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        <source>
            <dbReference type="EMBL" id="KAF2490799.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="531" mass="59823" checksum="1E7C704B3903F823" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QG70</accession>
    <name>A0A6A6QG70_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">BU16DRAFT_566094</name>
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        <name type="scientific">Lophium mytilinum</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2491181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        </location>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="37659" checksum="1191CCD549FC0B3F" modified="2020-06-17" version="1">MPSSSKPIGGYYSQLPYTPPPSTSTQTKPSDKPAPPAPPAPSAPPPPTSPTSSPPPQTVSKQDTAAPPPSTTSSNPKASATSISNPSSPPTSTSSALITNTIWIQPPGYSFLPGALTAPIPSILHFALPPFPHAANHSIAQSSSSNPCTPYSNGTAMGFWSGIPVENDYVTTGEDPAPVWQLRLVTADPVYFFDAGDGGDDGAWKCWKYGRVGVVNPVGGVDGGEIEALRSIAMGLSTMGHDGMPTGVPRGGEWVSMAQTTTTGAPTPETRVVATGTGTGNATGNASGTAKGGKGMSSLTVGGIVFGGLSLVGVLVLGWCLLKKRRDRRRLRVGHERNSSSLEFRDMAPASGPEMERLRSNERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH70</accession>
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            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Alfaro M."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="75"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2491768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="8812" checksum="A39A232E747DC05C" modified="2020-06-17" version="1">MSPPDQNTPGDMPALVTTEEAARIHSAEAPDQKNPRNIPAQTTKEDAARIQSAEAKSGNDPAFAARVQSAADKAANQTAGQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QH74</accession>
    <name>A0A6A6QH74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BU16DRAFT_128293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo domain-like"/>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="453" mass="50757" checksum="D6BC24A5E008368C" modified="2020-06-17" version="1">MKNSIVPRFATCTIEHCGKPAVRALSCAHCESHLCAKHQSRQFHRCPSISEANDDEVEELISRIDKSELVQIASTLNEGKHCTFRPGKHVGDGAIMGCPNYHAWIDFDDGEKWLVRIPRSDFSSIPATLVEYFVSSEYATLKFLETTKVPAPRAFGFGFLSDPANHVGVNYLLMQALPGNPYDSSIATGNQRNRVLRQFAGILVEISNHPFKKAGSLLLDRNGAFEVAAVASHRFITLGRYGPFRTDADYFATIADQHLDLIADGQLYHTYPKEAFLFYQLLRQHNHELCSNTSGNAFFLKQVNDKGDHLLVDEEHNIVGIIDWQFARTVPACEAFGPSLLTADFQTLYSRNAGVTEADRELFRALQDLQRADLATYASSSELVRRFHIGFARGLSRDDVCEMVAGVLRLSSPRAQDMDMNLWFSQEWANDQGDSCYAQIEDLEHSSAHEAFP</sequence>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QJT4</accession>
    <name>A0A6A6QJT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
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            <shortName evidence="16">PEMT</shortName>
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        <name type="scientific">Lophium mytilinum</name>
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    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QJT4"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2492220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="904" mass="102675" checksum="7949D593A89745ED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QKA2</accession>
    <name>A0A6A6QKA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_112333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004194">
        <property type="protein sequence ID" value="KAF2492390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QKA2"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025691123" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25410" checksum="5E123845803A2A90" modified="2020-06-17" version="1">MYFSSPLVLVLALAPSTLFALPTRQALSIPSLADFLSKRALAAPTFQRLTDGVCDLDGVTPALGDKNPLPPPTAGLRLYHVAVGRGTQNYTCASASETVVPVSKGAAATLFNATCAASRAPTTLSSTPAIALAFSVPTGDQAAALESGHHFFSNATTPVFNLDTAAHAFGIGSLKKTANTTAPADAPAGSNNMGSVAWLKLTGIEDGTFKEVYRVDTAGGNPPKNCSGISGDFDVEYSAVYWFYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QLC0</accession>
    <name>A0A6A6QLC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_564155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004193">
        <property type="protein sequence ID" value="KAF2492846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QLC0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="78"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2492846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="659" mass="73598" checksum="13CCBB3629746A2E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QM69</accession>
    <name>A0A6A6QM69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_84315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QM69"/>
    <dbReference type="Proteomes" id="UP000799750">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2493608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="85" mass="9295" checksum="7A485051D2B3CD0A" modified="2020-06-17" version="1">MPSLARSRFRAERAGCFVLVIFHRGPWRGFKRPETVTSLARPLLLARELKAGEGRPLISVHSMLLLPSPSLSRLLASSVSVKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6A6QN14_9PEZI</name>
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            <fullName evidence="7">Putative xylosidase</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_528780</name>
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        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2493476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="360" mass="40267" checksum="384AA4D475800864" modified="2020-06-17" version="1">MPLHSEVKPLFPQTQLPHLQNITPNFLPTMPPSPKPLISHIYTADPSAHVFNDRIYIYPSHDISTDIRDNDNGDQYAMTDYHVFSTPSLRSSSPPAVVTDHGPVLSLSQIPWAAKQLWAPDAAAKNGKYYLYFPARDMAGVFRIGVAVGEAPEGPFRAEPAPIPGSYSIDPAAFVDEDGAAYLYFGGVWGGQLQCWRGEDFNGDAYEEMEARGEEAALRPRVARLREDMLGFDEDGVREVEILMPDGTPVPAGDREKRFFEASWVHKRGGVYYFSYSTGDSHLLIYATGGSPLGPFTYRGVILRPVVGWTTHHSIVEFEGRWWLFYHDASLSGGVNHLRCVKVREIWYDAEGAIRLMDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ05</accession>
    <name>A0A6A6QQ05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BU16DRAFT_582413</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="328" mass="38256" checksum="50A1DC5732C4CDE0" modified="2020-06-17" version="1">MLLRCGISTQDGQRQPTASPLLNLPAEIRQQILFEVLSQSITIILDNTTIIATRLKRVCRLLRADFAEILPLWLPEPTTKVVIKSPEGTRRLADLQRQYTELAARSGRQWGGIQTIRMQVIRNIAWPQNPTTEIKADQLFTLNPLQDHDYALLPDTVNKIIVDLTMPPKPLRSIKAWWPDASHCRGAPPEGLAEFWYSFTYALCGSDMVVATGLFNVGNGPAYCNYHGTYGRDGKKLMSIETKGRFPPSHIQPMLFSKHVDWHRLSVVEIRFEDYFKEYKRKFQPHMQWWEDMRKEQWEADERKRKAEWEEQEKLEKPKRKKRKTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQ25</accession>
    <name>A0A6A6QQ25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_562240</name>
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    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10376811at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="331" mass="37460" checksum="940F151857747DB8" modified="2020-06-17" version="1">MANNQDNFANDSGFPSSTAQNSAAAGSSTSASTHARSTISLGDSRYPQPQTIQPYLNAPLEYQIQLPIPPNPSFQSLRQTPTRHVPFPNPIYVPSITTQPNLTVKIQSLIKVRRDLDWINALALHGSNPFTDKTTADRFKFYYREYNRLRSEVLTDVENLFVQFGAILPGTKIGVPDRVAKDWVKRNYGVILDDSSGDRAMDDRTLLQAAKAAEAAKRLTVVEEAKEMTVEEQAKSFHNPIRELESVVGNRPFSSYENMKGKPIQLRDTDHPRKQWIKLRNWNWRDAARMGGLREEEPLSPKSKKRKAIDDPLKGSSKRKMDEFGQRIYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQL0</accession>
    <name>A0A6A6QQL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="7 8">
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQL0"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2494778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="420" mass="45555" checksum="F9FAF182D0C8EF16" modified="2020-06-17" version="1">MANPHHGVTAAVEEENHITNRAAAGVSYFTPAQLPPAGTALHMKDEGEKIPKLFTPLKIRGLTLHNRVMLSPLCQYSAEDGHHTAWHFTHLGGIIQRGPGIAFVEATAVQAEGRITPEDSGLWKDSQIEPLKKIVEFAHSQGQKMGIQLGHAGRKASTVAPWLSAGDVAPVELNGWPDNVYGPSAIPYNPKHATPKAMTLDDIADFKAAFKASIQRALTAGFDAIEIHNAHGYLLHTFISPASNHRTDQYGGSFENRTRLTLEIVDIARATIPDSMPLFLRISATDWLEETDVTGWTVPETVRLAEILAERGVDLLDTSSGGLHEKQQIKGGPGYQAPFAKAVKDKLGDKLLVGTVGTITEGKQAEKLLVDDDLDLAIAGRMFQKNPGLVWAWADDLGVVCQWANQIRWGFGGRGKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QQU3</accession>
    <name>A0A6A6QQU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QQU3"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34812" checksum="86313525A1C458B2" modified="2020-06-17" version="1">MSSIESRSSAKGVPSPGDPDRKRILNVLAQRRYRQRRRERIAALEAQAQDSSSTSPLPQNPFPTPVVTPIESEPIQSNSDETTQLDFVLQTEPGSLVDLPNNTMGAATSSDFTSSFDPIIFDIPMPTFTDLDLSFPPSAISSTSPTYLNPASTPCFQFPLTPDRNIEVPILSTLRATLAIASVLSVQHSLHDLSCLHTLAPSPHLPQNLQPTEAQRNIPHHPVLDIFPWPTVRTKLICMLTSGAAQLSGGIAIMQLVSDMDDLAEGMRVSGTNELDEASWEVGEAMLKNWWWAFDAQIIGHSNQLRAMRGAPRLRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QR83</accession>
    <name>A0A6A6QR83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_618874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QR83"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2494911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="138" mass="16455" checksum="CFE3EC84A2AC1BE7" modified="2020-06-17" version="1">MQTRSQTRANAGRQARPRRLPKPRAAPRKKEKKTKKKPEEEEEETRESPPPAVPDDDDEDIEMEGVVETVETRLELENLQYEMYKMGKILDIVEKKNRKLGKKVEALEEEVKALRDKEERRSRRERRRLEEEAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRN2</accession>
    <name>A0A6A6QRN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_423525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4"/>
    <dbReference type="EMBL" id="MU004192">
        <property type="protein sequence ID" value="KAF2493537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRN2"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025642974" description="mannan endo-1,6-alpha-mannosidase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2493537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="398" mass="43676" checksum="D172C4A4013BFA68" modified="2020-06-17" version="1" fragment="single">SSVALAVVALSPLVASVNVNLDDEASIMSTVATYAYEMMTYYKNNATDTPKDEVGSFPKPPYYWWESGAVWGGLIDYWAYTNDSSYVNTTRDALVANFGPNQDLIMPNKRDQEGNDDQAFWIFALMSALEYQFPLPSDSDPQYLDVAKKAFDGMAARWDTKTCNGGLKWQIYPDSVVGYDYKNSVSNGAFFALAARLARYTGNQTYTDWAVKTWDWSQRIGLIGPKYEIFDGTDDKSNCSEVNHMQWSYGVGIYLHGAATMYNFTNGSAIWQQRTSGLLERSAVFFSPFKNATNVMWEAACEGAYSCNTDQQSFKAYLGRFLAKTAIMAQFTAPAVQILLRTSAAAAAKSCSGGSHGTTCGTRWYVGGYDGTYGLGQQLNALEVTQALLAGSAGAPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRQ4</accession>
    <name>A0A6A6QRQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BU16DRAFT_462308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRQ4"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2494849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="590" mass="63918" checksum="D8E2C3C36F2D63EA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QRT2</accession>
    <name>A0A6A6QRT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_462844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004190">
        <property type="protein sequence ID" value="KAF2494879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QRT2"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="128"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2494879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="382" mass="41713" checksum="268CBDC2B5418B75" modified="2020-06-17" version="1">MTILSKQPFKGIYVLFAMGATLAQMPIWVLKYIFQSGRQHPTWTFRQAFGERFMLAFLHHSAVVQVDGKLTLNPGKEKDRFITIDPAKASYYIGPLTSNDDVKPATIGATWYPSPLSKKADLSTETIVLHMHGGAFVIGDGRAEASGHAAKLLLKHTSATHILKPQYRLSTLPASKTSNPFPAALQDTVTAYVYLVHDLQVPPTNIIISGDSAGGNLAIALTRYLAEYGAQLKLPNPAACWLFSPWISPMLSTSEATVVARPQFHIDYLPLSFINWGTAAYSGLKGYSVLSNPYIEALGTSFETRVPIWANSGEAELLYSDIKKFTDEMGAVEGNRVVLDIEEAAPHDVVLVGNINGFEVAGENTARRAGDWWEGVRKGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QSQ2</accession>
    <name>A0A6A6QSQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_539390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <fullName evidence="4">RNA recognition motif-containing protein</fullName>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2495921.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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            <name>heme</name>
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    <comment type="similarity">
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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                <person name="Gonzalez J."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 269.34</strain>
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    <dbReference type="AlphaFoldDB" id="A0A6A6QUD6"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2494527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="742" mass="80194" checksum="5B847AF0963BA503" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QV12</accession>
    <name>A0A6A6QV12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BU16DRAFT_509146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QV12"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2496245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="280" mass="29922" checksum="2B1028AC8769BAF3" modified="2020-06-17" version="1">MARLPVHREPKHQRNGHASDQRRSRRSPPELSTLQAHLVAASGEFVGTFMFLYFSFACQIMLTTQASEKSLANGGPSSQQNIFTALVYGFSLLVNVWAFYRISGGLFNPAVTFGMVLAGALPPIRGLILFPAQIIAAMCAGGLVSCMFPGDIASTNTTLAPGVSIASGVFIEMFMTAELVFVVLMLAVEKSKDTFIAPVGVGLALFVAMMGGVYYTGGSLNPARSFGPAVAATQFPGYHWIYWVGPLLGGAVAAGYYRFVKYFNYEQANPGQDATDGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QVT1</accession>
    <name>A0A6A6QVT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_526798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QVT1"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="13">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="12">
        <location>
            <begin position="297"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2496306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="485" mass="52779" checksum="78A2D101F412B4D3" modified="2020-06-17" version="1">MSAKSIFEADGKAILNYHLTRAPVIKPTPLPATATHNPPARLASLHFPADAAPKDVLDQAEVTFPWLLVSGSKFVAKPDQLIKRRGKSGLLALNKTWAECRAWIEERAGKPQRVETVDGVLRQFLVEPFVPHPQDTEYYININSVREGDWILFTHEGGVDVGDVDEKAEKLLIPVDLSEYPSNEEIAATLLKKVPKGVHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNADATSAEVHFLDLAAKIDQTAEFECGVKWAIARSATALGIPQIATKDAKVTVDAGPPMEFPAPFGREMSKEESYIAEMDAKTGASLKLTILNSTGRVWTLVAGGGASVVYADAIASAGFASELANYGEYSGAPSETQTYHYARTVLDLMLRAPVHPEGKVLFIGGGIANFTNVASTFKGVIRALREVAPVLNEHKVQIWIRRAGPNYQEGLKNIKGVGQELGLNMHVYGPEMHVSGIVPLALNGKQTDIKEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW40</accession>
    <name>A0A6A6QW40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_526453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2495913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1564555at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2495913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="241" mass="25961" checksum="A79C7AEBA719C2B0" modified="2020-06-17" version="1">MASQTLTPEVLWAQRSSSTDATKNYIYINVVVPNVSESDLKLDLQPTKLTFTGTSASKHKTYHVELEFFAEIDPKESKTINSGQTVELVLRKKELNEAYWPRLLKDSRKMHFLKTDFNKWVPEEEQDETPEDDEYMNKMNPMGGEGGGEGGFGGIDFSKLGAGGMGGMGGMAGLEGLGGMGGMGGLPDLQDMAENGEDSSPSDDDDDEMPALEGDDEKPAAASTTKEAPAPAAAAKIQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QW70</accession>
    <name>A0A6A6QW70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BU16DRAFT_617801</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QW70"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="289"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2496354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="454" mass="50807" checksum="12563CE8A795A3D9" modified="2020-06-17" version="1">MPSTQFALKEKYRYLNGFNSYHESEAIEGALPVGANSPQQPPYGLYAEKLSGTAFTAPRHENQQSWLYRILPSSAHAPYEARESATYNTNPENKPHEKIHHIPNQLRWDPFDMDETVDWVHSLHLVAGAGDPTMKTGIGIFIFAAGKDMDPHEAFYSADGDFLIVPQHGVLDIQTELGRLLVRPNEICVIPRGIRYRVTLPYGPVRGYILELYQGHFQLPELGPIGSNCLANARDFQTPVAAFDEDTSTTWHVLSKFAGHLFSAKQSHTPFDVVAWHGLYYPYKYDLGRFNTLGSISYDHPDPSIFTVLTAPSDHPGTAVADFVIFPPRWLVAEDTFRPPWYHRNTMSEFMGLIHGQYDAKTGGGFQPAGASLHNVMSAHGPDAATHSKASNAALQPAKVGEGSMAFMFESCYMVGVTEWGLKKCRKVQEDYNAESWEGLEVRFRRPETSENPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QWG3</accession>
    <name>A0A6A6QWG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_582034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004189">
        <property type="protein sequence ID" value="KAF2495317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QWG3"/>
    <dbReference type="OrthoDB" id="5413280at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2495317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="262" mass="30205" checksum="B7E3636E77B0BAE1" modified="2020-06-17" version="1">MSSRYPPPKTRSLPPAYGRYPPEHDEYDEYGRAVQVRSPHNAGVVYEDPRYFSSAPRSEPRRAGRSVHFDKALVQLAEGYEAAEPVITEFKAGFDQEMGAIKMYADDEILDRLWHARVQFKPKADQRKGKDQEDQDDDNGSEEELLAKSKDFQKSLQALIRGLESSMNATPTLQSKSKLTQKEKENVERVVRKLRPASEECLKLARQAGKRVTQLQELLKELAYLKLMIDEWPEFTSPESRRRNDESFEEGEDYDNGSREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QXJ9</accession>
    <name>A0A6A6QXJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BU16DRAFT_561202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004188">
        <property type="protein sequence ID" value="KAF2496383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QXJ9"/>
    <dbReference type="OrthoDB" id="9922773at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2496383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="140" mass="15750" checksum="DCDF7014A33730CB" modified="2020-06-17" version="1">MYGRALRVLPPVSLAPYHKTSLLLGTIVIPSSTPAENLLPASRSYCTSCKKSALLRNCASCCIIRHCSVGCQRADLKRHKKEYRAHHEQKVSDEEKASTAKSVEKRSVAGEQQGEERRLRKSPMLWVTNRLLYWPKLGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYI2</accession>
    <name>A0A6A6QYI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BU16DRAFT_580785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004187">
        <property type="protein sequence ID" value="KAF2496703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6QYI2"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2496703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="251" mass="26874" checksum="8D1DF149BB7925DF" modified="2020-06-17" version="1">MPSYLITGTSRGLGLEMASQLSKNSENLIFATARGAPTPALQKLIDGSSGRVVYVQLDAEKEESIKSAVVQVEKHLNGKGLDILINNAGVMPFALNGVATMDNLSSTFSTNVLSVHLVTSAFIPLLQKGTEKKVFNVSTTLGSIAHAATYRQMPAPAYAVTKAALNMLTVQYSLGYEDQGFTFIALTPGWLKTDLGGDAADLPVEVGAEATLKIVQERGKEDTGKFINIKVAGWEKAPGRMNYYDGEEVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QYP8</accession>
    <name>A0A6A6QYP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_457595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
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    </dbReference>
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        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
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    </dbReference>
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        <property type="entry name" value="G_ALPHA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2497575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="354" mass="40680" checksum="81FFCFCBDE2581FF" modified="2020-06-17" version="1">MRELVCRGDEVEMKTRSHAIDRQLELDAWELIMERRVLLLGSKSSGKDVILKQMRILHPSGDTREELESHRITIYKNLIDSAKALVGAMDQLNIIPDTEKTRKHLTFLKNLKFYADPQKPLGTEVGESISALWNDPCTARLMEHSTGFFLLDSAPYLFHEARRVASPYYIPSEEDVFRAGRKVTGYHETRIAMDQLSIRIFDLVDPRTVKRKLMPYFKDFTAVIFVVDLACYDQSILGDSSYSELMNDLIYFDSVVNSRWFDGPSMILFLNNVDKFKEKLGRSPLSNYFPDYNSGNDASKAKKFILSRFDQISRGRLNVYSHFTQPMDTSSIRQVFAAVRETLLNHVPVPSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZU9</accession>
    <name>A0A6A6QZU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_457309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3231004at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2497632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="426" mass="47459" checksum="D9E2D0556AEB2962" modified="2020-06-17" version="1">MAQLLAPYHNGMRLGQGFNSYTQQICLDNAVLLNTAENRTKATDESTEVNLTGRPPWTKPQIVTYSSRFVDKLSDVTDSMNISGALSIQTATVGGKGSGSYVDSDKFKESDINFHLQVKVVNQIHKFDEYSLFNKIHTVRDADFPAVYGDTFISGWEEGGEFNAIISMKVTDKSKTFEVKASLEATLSLSGMKGGDLKVQFEMVKNNISKNTETTIAVNWSGGGSIKDPEEAWTMESMKKAAAAFPDLVAITPQRTYAILTKYIALESFQRQRANYSQLDYENAGIYTAALLDHYMDYKMMWKQLSQATYELEANRAKIDWAQLDEETSLLARINPLPDDDIGKKLSQSEGSAQDPFKPSFPGLIAARKICRIEMAKIVNEVDLVTRKPLTAQETIRDSYFLHPLIFKMLLPVSSGDAKATQSNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6QZY6</accession>
    <name>A0A6A6QZY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BU16DRAFT_616185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="367"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="745"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2497564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="883" mass="97047" checksum="F24DC93EDBF0F31F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R036</accession>
    <name>A0A6A6R036_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BU16DRAFT_548887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497886.1"/>
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    <dbReference type="Proteomes" id="UP000799750">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2497886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122989" checksum="F3B73A4FC52BD866" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R051</accession>
    <name>A0A6A6R051_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_559358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R051"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2497624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="79" mass="8983" checksum="CDD17BC06995902B" modified="2020-06-17" version="1">MSFYDEIEIEDMTYDSALEIYHYPCPCGDRFEIAIADLRDGEEVAVCPSCSLMIKVIFEVDDLPKEEKKEDAQKVAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R056</accession>
    <name>A0A6A6R056_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_525474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R056"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2497889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="274" mass="30194" checksum="4C0EE2D98B6E8762" modified="2020-06-17" version="1">MALADWIPRLLRPSLLLGLAVYHFGMTILETIFVHREPSLLFNLSKLREKSFARIWINNGEAMSLEMPGNLDELLQTVHGTVLDVGPGSGEQLTRFDASKVDIMYGAEPGIDLHPGLLRSAEKTGFGGKYKALHCGGEPESLIPALAKASVFKDGASQGVFDEVVCVRVLCGVPRPEETIQGLYRLIKPGGRLIFCEHVINPWRDDGAILARLFQAIYALLGWKFFMGGCTVDRNTKQYLLDAAGKEGWEEVHLESVDPTTAIPFIVGYLVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R067</accession>
    <name>A0A6A6R067_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_506875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R067"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="621"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2498095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="903" mass="102888" checksum="F337ECB452E0A4E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0A6</accession>
    <name>A0A6A6R0A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_286669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0A6"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="65"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="427" mass="46731" checksum="C45B66C3DFAA0AB1" modified="2020-06-17" version="1">MAPSSLSDPAISQIKALLTTFLASSTTSSPGIGIQVTTAAGTQLLSFSAIPESAPSTQFQTSHKTFSPTSIAPIHSFTKLVITIACLQLVERGLFSLDDEALIPTHLPELAEKKLFVGFADNEPGTPNFEDRKSSLTLRHLLTHIYGGAHSFFDAKLLAYQQEIGKGNWPTNFWHSMRDSPLCYQPGERFAYGAGMDWVAVLIERVTGQSMSANLASNVFEPLGMADTSYIREVPEALKHRVCVASFGAFAQIFKDWDKPMEKDVEEEKAGKARQHRYPGSVGLFSSMRDFGKLLAVLLNRGTCPAIGIQVLRTETVQQMFQPQTSSEAARWRQVGSTLPAIALPVDLTIKDPVGNVGLGGCVQGENRGRGRKKGSLYWYGATNLDWWVDPAAGIAVQIWGNYSPWNDEKWVEVVDALEGMVYGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0H8</accession>
    <name>A0A6A6R0H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BU16DRAFT_615332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0H8"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2498268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="263" mass="29407" checksum="42FF5C20039C261B" modified="2020-06-17" version="1">MNYLRNMVTLTPFAPESTRPEPIEGPALPWNPSPSDTILVRSYLVHLKLPTELALTIIDYAQYYPIVRGHRDEELKVVASNYKGNSAAALYVVSEPIPAIENGERIKRKTVKFKVRSRDQGWGGEHGCPGTYNGSFTWFEASILRPSGSAKVTFIPLNMIISPRPTSSSLERYHVSLAAPSNTPNDPVWHIQRNMCASPQERTYEVEWRDGSTFDPLPGSGDGQGFCETLQPGDRIAIWARALYPGWENHVKEVGVEVLLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0S1</accession>
    <name>A0A6A6R0S1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_333771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2498086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0S1"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="174" mass="18613" checksum="648B02246C0F7716" modified="2020-06-17" version="1">MGCGSSTHSSRSLTPIQNPSLKDLKDFLGPENGRAARSVVPQNPPTSQNRKPGQPQPTRVAPGFAPKWSSIGGGKSRPPSPAHSSSQCPGSNSEVQAMPGFGYHLGARALPCVNARRDAMSYGSYAHGTVENFQEECHECQVREPPLGSSKHQSLWRSSVVEVKFWSFGLAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R0U7</accession>
    <name>A0A6A6R0U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_506704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lophium mytilinum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004186">
        <property type="protein sequence ID" value="KAF2497992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R0U7"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        <location>
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        <location>
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        <location>
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            <end position="637"/>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2497992.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="902" mass="99648" checksum="6A876F858AAF04C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R115</accession>
    <name>A0A6A6R115_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BU16DRAFT_287605</name>
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        <name type="scientific">Lophium mytilinum</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAF2498219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0016747">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_7"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
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            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2498219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="234" mass="26328" checksum="E79987431A95C393" modified="2020-06-17" version="1">MPPSAHLVLPAQPADTPKVYDIYFLAFAGSALPRLLFPSAYPTASDTVPTAEFRESHTAHTLAWLASPASGFQYTFKAVDVASGEVVGMGLWDIHLTERTEEEWKWKGVEWLAGKERERAEELLGEMVRKKEGFFGGKRHVYCHVVAVHPEYQKRGIGRKLMQWGIEVGEQAGLPVYLESSVEGEGLYRSLGFEEVGRVRHRGELVGEAEDVEVPLMVRMPKSLEIGWEEWCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R1V3</accession>
    <name>A0A6A6R1V3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BU16DRAFT_525417</name>
    </gene>
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        <name type="scientific">Lophium mytilinum</name>
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            <taxon>Mytilinidiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
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            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2497823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="386" mass="41668" checksum="00158B9D50F7B9A8" modified="2020-06-17" version="1">MSDKPAKPAIPSWQRATPPASSSSPGAEDSTRDETQTAAESQEDQPREEDTTSEDPTLLEQALEFLEDPAIRDAPRDRKAAFLESKGVTKENIQKLLGAADEPKTSPSVATSGEQPWPKTSSAPKAQPRDIPPIVTYPEFLTQSTRPPPLITARRIATTAYVAGAVATAIYGISKYIVSPMTDTLSDARHDFASHAQSHVEEFNTRLGDIVSVDPATTSKLLKPIDHSDDISEADSDPTELYHRDFGTQTTPSLSRRPSVSSNTNSDPEANTTVAIHETRLKSLTSHLRELEATHNNDTSSADSLRASLTDLNTYLNEMTYQSYHSYSGGLYGGSNYGMPRGKDGKEDQVEALKAEIRGVKGVLLSARNFPAGGGRVRSLVGATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R2M8</accession>
    <name>A0A6A6R2M8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_523630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R2M8"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="330" mass="38204" checksum="40BA8477806F457A" modified="2020-06-17" version="1">MHTDLRSPAYYDPALYPLSKGRHLPTAWISQTPLPKRTPSPPPSTPFRIFDLPTELRLKILRYVLPHHRVIEVGPRTIKPYFARSAGTPSCVIRLRLTQLPSDLNTSRNILAVCKSFRAEAGDILYGENTFRFVVSRDMLGANNIENPFAWVPDGVLAQMRKCEILISEVLERPAVYRRVRRWLERLVQRMGEGYALQRLKVELLKGRLVPWRHAFNMQGWAVQRFRPSARVEGSNGFQFVLEPLARLREVREVRIQGHVDEGFKAMMEEVMGVERTWDGLTARVYPEKVVLRKKKAGVKKTYQMMSTKKFWQPEFDWGVVGDDEIMSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4I0</accession>
    <name>A0A6A6R4I0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BU16DRAFT_523710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4I0"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2499214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="256" mass="28054" checksum="9EFCF3CFA3E3B632" modified="2020-06-17" version="1">MPAPTAPLGSPEVLAEDQTMTEAPAALEEQTALIDTNALPSDTIGILEPSDEPTDAAMTIDGRPQFAPAAESQMKYRREQRKIPIPPHRMSPLKAAWPKMYPPLVEHLKLAVRMNMKSKAVELRSSKSAQAGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIETFEIKDVKTLTGEHLSRCIGRIAGKDGKTKFAIENSSRTRVVLADSKIHILGGFKNIHIAREAIVSLILGAPPGKVYGNLRTVASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4Q7</accession>
    <name>A0A6A6R4Q7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_524817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004185">
        <property type="protein sequence ID" value="KAF2498753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4Q7"/>
    <dbReference type="OrthoDB" id="3940729at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="64"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2498753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="368" mass="40442" checksum="58ECD43F45DE3659" modified="2020-06-17" version="1">MLTTLTHPPCAPAQPTESPFIIQIDDSTDEKSDVSSTPSHTSIDAPPGPTSARYTPADELVAGYPRLAGFMSLAPETVILRRFTALNIQNLLYLQAELKHLEFELRAQEKLDAQTEKGKRRMYARDWFWLSVSEEDEDGRQWGIVRRMRGVLKEYNEALLQQQSLAKLQLPSKSALRTLQDWLARPTGGQYSLIGRDCRIWGYRFTTTDQARDLIAPLANIEDRFSATLVSYLLLPFRLLRAVIPAPSFKPKTTTTTSKSLPFLRESVLEAQLQRCSVICRVTAVVTAVAASLLPVVSVVILYSLSSMKARLGVMAGFDTLFAFLLAGCATVRRGEVFAATAAFAAVQVVFIGTSGSGNGNGTGMSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R4Z0</accession>
    <name>A0A6A6R4Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BU16DRAFT_453687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R4Z0"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2499394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="646" mass="72817" checksum="9C155000085D80A3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R595</accession>
    <name>A0A6A6R595_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BU16DRAFT_478034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 269.34</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="MU004183">
        <property type="protein sequence ID" value="KAF2499955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R595"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="295"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2499955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="413" mass="43615" checksum="12F49EDCB74A20C5" modified="2020-06-17" version="1">MASFIQKGAKNILQKSPHDVVFLSALRTPVTRAKKGGLRDAYDHELLAAVLKATIDRHPNLDPSKIDDICIGTVLSELGGSKAGRMAANHIGIPTTTSFHTLNRACASGLSAVTTIAHAIAVGSIDVGIGGGMESMTRNYGSRAIPTQLWNDLKESPVKDARDCIMNMGLTAENVAERYGVNRADQDAFAARSQQKAAKAQQSGFFDKEIVPVTTRWVPDPTVPEGEESITVTKDDGIRPTTTAEKLGGMKPAFKEDGTSTAGNSSQVSDGAAAALMMRRSTAQELGLSGSIIGKWAGSQVAGCRPDEMGVGPAVAIPKLLEYTGVAKEEVGIWEINEAFASQALYCIRELGLDEEKINPKGGAIALGHPLGATGGRMLATLLHEMERQTEELGVISMCIGTGMGMASLIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5G3</accession>
    <name>A0A6A6R5G3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_558106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5G3"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="158" mass="17570" checksum="4F8709E496893C47" modified="2020-06-17" version="1">MDNGAAVNSDIRHPQKAPRYWRLWGYGGKVWATSLSAERPARRCRYANALRKTHEVDVSTPANGHMVVTVSKGLHPIGLHRTQEEPSVTRQMDLATGTSTCIVSLPLDWQGSSGGPRRHGPVNQFTSSAPAPLQLGKLRTQHHWPEKLRRSDPRKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6A6R5G5</accession>
    <name>A0A6A6R5G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BU16DRAFT_280786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lophium mytilinum</name>
        <dbReference type="NCBI Taxonomy" id="390894"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Mytilinidiales</taxon>
            <taxon>Mytilinidiaceae</taxon>
            <taxon>Lophium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 269.34</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MU004184">
        <property type="protein sequence ID" value="KAF2499716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6A6R5G5"/>
    <dbReference type="Proteomes" id="UP000799750">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2499716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799750"/>
        </source>
    </evidence>
    <sequence length="345" mass="38361" checksum="F55F2EE1BC6AAF71" modified="2020-06-17" version="1">MSAMAHYLGTPPCAPRHLITCSDLPSGCCVQRLQLPAINRSHALVRRILHCDQPRRRPRGFTSDDPDSGTGREIRDRSARRLCFRLRCGMAREWEQLFTSWQVPDKKSGPARIATSPENPKHAEALARMRLQRPGGTIPLHSCRQLHRTRPMSSTWDALNLANRRRCQKGSMLIQSQADGPLLVSCMCRRAQHVDGAERSGGGQLTRWVLRAGPAHCVGVAVVVPLNSPTPDRRICREAIGGIHCASSSTRPNRLHRSVHANVMHARDPRQHVPRPGAVEPCHAHALGRAKWSR